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https://www.readbyqxmd.com/read/29125715/two-phase-1-open-label-single-dose-randomized-crossover-studies-to-assess-the-pharmacokinetics-safety-and-tolerability-of-orally-administered-granules-of-secnidazole-2-g-in-healthy-female-volunteers-under-different-administration-conditions
#1
Helen S Pentikis, Nikki Adetoro
Bacterial vaginosis (BV) is the most common vaginal infection in reproductive-age women and a significant risk factor for sexually transmitted diseases and pregnancy complications. Standard 5- to 7-day antimicrobial treatments for BV are associated with high rates of recurrence and adverse events. SYM-1219 is a novel granule formulation containing 2 g of secnidazole, developed as an oral, single-dose BV treatment. Two phase 1, open-label, single-center, randomized, crossover trials (studies 102 and 103) assessed the pharmacokinetics and safety of SYM-1219 single doses (≥7-day washout between doses) in healthy, nonpregnant women aged 18 to 65 years inclusive...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29095347/randomised-trial-of-a-yogurt-type-amino-acid-based-formula-in-infants-and-children-with-severe-cow-s-milk-allergy
#2
François Payot, Alain Lachaux, Florent Lalanne, Nicolas Kalach
OBJECTIVES: Evaluation of a spoon-fed amino acid-based formula (AAF) with a yogurt-type texture compared to the reference oral liquid formula (Neocate). METHODS: Phase III/IV, prospective, randomized (1:1), open-label, multicenter study in infants/young children (6-36 months) with severe cow's milk protein allergy (CMA) who had consumed AAF for ≥1 month before the study. Patients received reference+test formula (Neocate with a yogurt-type texture for spoon-feeding: Group 1) or reference formula (Group 2) for 28 days...
October 31, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29091111/adding-palm-oil-to-the-diet-of-sheep-alters-fatty-acids-profile-on-yogurt-benefits-to-consumers
#3
Anderson E Bianchi, Aleksandro S DA Silva, Angelisa H Biazus, Neila S P S Richards, Luis G Pellegrini, Matheus D Baldissera, Vicente P Macedo, André L F DA Silveira
The aim of this study was to modify the fatty acid profile of yogurt from sheep milk by the inclusion of different concentrations of palm oil into their diet. Thus, thirty-six sheep during lactation were separated in four groups with nine animals each, as described below: the group T0 (0%); the group T2 (inclusion of 2% of palm oil); the group T4 (inclusion of 4% of palm oil) and the group T6 (inclusion of 6% of palm oil). After 60 days of the supplementation, milk samples were collected and yogurt was produced, which was evaluated regarding the concentration of saturated fatty acids (SFA), monounsaturated fatty acids (MFA), and polyunsaturated fatty acids (PFA)...
October 26, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29084251/is-yogurt-intake-associated-with-periodontitis-due-to-calcium
#4
Hye-Sung Kim, Young-Youn Kim, Jeong-Kyu Oh, Kwang-Hak Bae
The purpose of this study is to determine whether the lower intakes of yogurt, milk, and calcium are associated with periodontitis in a nationally representative sample of Korean adults. This study comprised 6,150 adults 19 or more years old who took both periodontal examination and nutrition survey. The frequency of yogurt and milk intake was examined with a food frequency questionnaire. The amount of calcium intake was calculated with dietary intakes data gained from complete one-day 24-hour recall interviews...
2017: PloS One
https://www.readbyqxmd.com/read/29083435/dairy-intakes-in-older-irish-adults-and-effects-on-vitamin-micronutrient-status-data-from-the-tuda-study
#5
E Laird, M C Casey, M Ward, L Hoey, C F Hughes, K McCarroll, C Cunningham, J J Strain, H McNulty, A M Molloy
BACKGROUND: Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for health in older adults is three servings per day but recent analysis of the NHANES data for older adults reported 98% were not meeting these recommendations. No studies have investigated the consequences of such declines in the dairy intakes of Irish older adults and the subsequent effects on vitamin micronutrient status...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29083056/intake-of-milk-or-fermented-milk-combined-with-fruit-and-vegetable-consumption-in-relation-to-hip-fracture-rates-a-cohort-study-of-swedish-women
#6
Karl Michaëlsson, Alicja Wolk, Eva Warensjö Lemming, Håkan Melhus, Liisa Byberg
Milk products may differ in pro-oxidant properties and their effects on fracture risk could potentially be modified by the intake of foods with antioxidant activity. In the population-based Swedish Mammography Cohort study, we aimed to determine how milk and fermented milk combined with fruit and vegetable consumption are associated with hip fracture. Women born 1914-1948 (n=61 240) answered food frequency and lifestyle questionnaires in 1987-1990 and 38 071 women contributed with updated information in 1997...
October 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29081890/role-of-diet-and-nutritional-supplements-in-parkinson-s-disease-progression
#7
Laurie K Mischley, Richard C Lau, Rachel D Bennett
OBJECTIVES: The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS: The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake. In this cross-sectional analysis, regression analysis was performed on baseline data to identify the nutritional and pharmacological interventions associated with the rate of PD progression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29075804/milk-and-other-dairy-foods-and-risk-of-hip-fracture-in-men-and-women
#8
D Feskanich, H E Meyer, T T Fung, H A Bischoff-Ferrari, W C Willett
The role of dairy foods for hip fracture prevention remains controversial. In this study, among US men and women, a glass of milk per day was associated with an 8% lower risk of hip fracture. This contrasts with a reported increased risk with higher milk intake in Swedish women. INTRODUCTION: The purpose of this study was to examine whether higher milk and dairy food consumption are associated with risk of hip fracture in older adults following a report of an increased risk for milk in Swedish women...
October 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29058428/effect-of-germination-and-fermentation-on-carbohydrate-composition-of-australian-sweet-lupin-and-soybean-seeds-and-flours
#9
Kornelia T Kaczmarska, Maria V Chandra-Hioe, Dimitrios Zabaras, Damian Frank, Jayashree Arcot
This study investigated the effect of germination and fermentation on the composition of carbohydrates in Australian sweet lupin. Specifically, the amount of sugars (sucrose, fructose, and glucose), starch, oligosaccharides (verbascose, stachyose, and raffinose), and dietary fiber were measured in germinated lupin seeds and fermented lupin flour, and compared with those in soy. High performance liquid chromatography coupled with refractive index was employed for quantitation of sugars, starch, and oligosaccharides, and gas chromatography coupled with a flame ionization detector was used for quantitation of simple sugars in total, and soluble, and insoluble dietary fiber...
November 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29056165/the-leaky-gut-and-altered-microbiome-in-chronic-kidney-disease
#10
Wei Ling Lau, Nosratola D Vaziri
Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events are largely mediated by (1) heavy influx of circulating urea to the gut lumen and (2) dietary restrictions of foods containing high fiber (such as fruits and vegetable) and symbiotic organisms (such as yogurt and cheese) imposed to mitigate hyperkalemia and hyperphosphatemia. Collectively, these factors promote systemic inflammation and cardiovascular morbidity by mediating microbial dysbiosis, disruption of the intestinal epithelial barrier, and translocation of endotoxin, bacterial fragments, and uremic toxins across the "leaky gut" into the bloodstream...
November 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29055979/investigating-the-effect-of-aqueous-extracts-of-basil-and-savory-on-antioxidant-activity-microbial-and-sensory-properties-of-probiotic-yogurt
#11
Zohreh Ghaleh Mosiyani, Rezvan Pourahmad, Mohammad Reza Eshaghi
BACKGROUND: The low viability of probiotics causes the short shelf life of fermented products. Therefore compounds which prolong the viability of probiotic bacteria can increase or at least maintain the health- benefiting properties of these products. On the other hand, the addition of antioxidants is one of the methods to increase the shelf life of food products which has recently become more prevalent. In this respect, herbal extracts which are a good source of antioxidants can be appropriate alternative...
July 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29054139/mc-media-pad-acplus%C3%A2-for-enumeration-of-aerobic-counts-in-a-variety-of-foods
#12
Hajime Teramura, Gail Betts
The MC-Media Pad ACplus™ is a dry, rehydratable film medium for the enumeration of aerobic bacterial colonies.The performance of the method in a variety of foods was compared to that of U.S. reference methods: U.S. Department of Agriculture (USDA) Food Safety and Inspection Service (FSIS) Microbiology Laboratory Guidebook (MLG) Chapter 3.02 "Quantitative Analysis of Bacteria in Foods as Sanitary Indicators" (USDA/FSIS MLG 3.02); Standard Methods for the Examination of Dairy Products (SMEDP) Chapter 6 "Microbiological Count Methods, Standard Plate Count Method" (SMEDP 6); AOAC Official Method(SM)966...
October 20, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29048784/-tracking-casein-phosphopeptides-during-fermentation-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#13
Hao Dong, Yang Yu, Jiaze Yan, Yan Jin
Casein phosphopeptides (CPPs) are phosphorylated fragments of casein, which have a variety of biological functions such as promotion of mineral absorption, antioxidation and prevention of dental caries. This study investigated CPPs in milk and yogurt fermented by Lb. bulgaricus (Lactobacillus debrueckii subsp. bulgaricus) and S. thermophilus (Streptococcus thermophilus) with high performance liquid chromatography-tandem mass spectrometry. The results showed that milk contained endogenous CPPs, which were mainly derived from high abundance of caseins αs1-CN and β-CN, in the role of endogenous protease...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29026484/serum-lipid-levels-in-relation-to-consumption-of-yogurt-the-2012-korea-national-health-and-nutrition-examination-survey
#14
Bong-Kyung Seo, Nam-Eun Kim, Kyong-Min Park, Kye-Yeung Park, Hoon-Ki Park, Hwan-Sik Hwang
BACKGROUND: The purpose of this study was to evaluate serum lipid levels in Korean adults after consumption of different types of yogurt. METHODS: Study subjects were 3,038 individuals (≥19 years of age) who participated in the 2012 Korean National Health and Nutrition Examination Survey. Yogurt intake was assessed with a food frequency questionnaire by using the 24-hour recall method. We conducted complex samples general linear analysis with adjustment for covariates...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28994611/modeling-the-survival-of-salmonella-enteritidis-and-salmonella-typhimurium-during-the-fermentation-of-yogurt
#15
Derya Savran, Fernando Pérez-Rodríguez, A Kadir Halkman
The objective of this study was to evaluate the behavior of Salmonella Enteritidis and Salmonella Typhimurium, the two most important serovars of salmonellosis , during the fermentation of yogurt. The microorganisms were enumerated in milk throughout the fermentation process at three initial inoculum levels (3, 5 and 7 log CFU/mL). DMFit software was used in the fitting procedure of the data (IFR, Norwich, UK, Version 3.5). The data provided sigmoidal curves that were successfully displayed with the Baranyi model...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28989578/chia-seed-salvia-hispanica-l-added-yogurt-reduces-short-term-food-intake-and-increases-satiety-randomised-controlled-trial
#16
Aylin Ayaz, Asli Akyol, Elif Inan-Eroglu, Arzu Kabasakal Cetin, Gulhan Samur, Filiz Akbiyik
BACKGROUND/OBJECTIVES: Several studies have reported that consumption of Salvia Hispanica L.,commonly known as chia seed, may exert beneficial effects on health outcomes. The main purpose of this study was to examine the influence of chia seed consumption as a mid-morning snack on short-term satiety. SUBJECTS/METHODS: Subjects (n = 24) were tested using a randomized, cross-over design consisting of three mid-morning snacks. Yogurt with no chia seed, yogurt with 7 g chia seed, and yogurt with 14 g chia seed were given to subjects on different test days...
October 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28987582/rheological-and-sensory-performance-of-a-protein-based-sweetener-mnei-sucrose-and-aspartame-in-yogurt
#17
Nicoletta A Miele, Erliza K Cabisidan, Giuseppe Blaiotta, Serena Leone, Paolo Masi, Rossella Di Monaco, Silvana Cavella
Sweeteners and flavors are generally added to yogurt to make them more palatable. However, the addition of these ingredients may affect the fermentation process of yogurt as well as its physical and sensory characteristics. Consumers prioritize yogurt products that are "natural." A modified single-chain form of the natural sweet protein monellin extracted from the fruit of Dioscoreophyllum cumminsii, called MNEI, could be a useful alternative to artificial sweeteners. The aim of the present work was to evaluate new rapid sensory methods in combination with rheology to assess the viability of using MNEI to develop sweetened yogurts without the calories of sugar...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28985138/optimal-combination-of-soy-buffalo-and-cow-s-milk-in-bioyogurt-for-optimal-chemical-nutritional-and-health-benefits
#18
Gehan Ghoneem, Magdy Ismail, Naeem El-Boraey, Mohamed Tabekha, Hoda Elashrey
OBJECTIVE: Soy milk is enriched with nutritive elements such as proteins, unsaturated fatty acids, lecithins, isoflavones, mineral substances, free amino acids, and polypeptides. The aim of this study was to increase the health and nutritional values of bioyogurt by using ABT-5 culture and mixing soy milk with buffalo and cow's milk. METHODS: Five treatments of yogurt were made from soy, buffalo, and cow's milk and from 75% buffalo + 25% soy milk mixture and 75% cow + 25% soy milk mixture using ABT-5 culture...
October 6, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28976265/evolution-of-serum-25ohd-in-response-to-vitamin-d3-fortified-yogurts-consumed-by-healthy-menopausal-women-a-6-month-randomized-controlled-trial-assessing-the-interactions-between-doses-baseline-vitamin-d-status-and-seasonality
#19
Jean-Philippe Bonjour, Flore Dontot-Payen, Emilien Rouy, Stephane Walrand, Brigitte Rousseau
BACKGROUND: Adequate vitamin D status contributes to bone fragility risk reduction and possibly other pathological conditions that occur with aging. In response to pharmaceutical vitamin D3 supplements, several studies have documented the influence of doses, baseline status, and seasonality on serum 25-hydroyvitamin D (s25OHD). OBJECTIVE: Using fortified yogurt, we investigated in one randomized controlled trial how both baseline status, as assessed by measuring s25OHD prior the onset of the trial, and the season of enrollment quantitatively influenced the response to the supplemented (Suppl...
October 4, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28971601/yogurt-consumption-during-pregnancy-and-preterm-delivery-in-mexican-women-a-prospective-analysis-of-interaction-with-maternal-overweight-status
#20
Jennifer L Kriss, Usha Ramakrishnan, Jennifer L Beauregard, Varun K Phadke, Aryeh D Stein, Juan A Rivera, Saad B Omer
Preterm delivery is an important cause of perinatal morbidity and mortality, often precipitated by maternal infection or inflammation. Probiotic-containing foods, such as yogurt, may reduce systemic inflammatory responses. We sought to evaluate whether yogurt consumption during pregnancy is associated with decreased preterm delivery. We studied 965 women enrolled at midpregnancy into a clinical trial of prenatal docosahexaenoic acid supplementation in Mexico. Yogurt consumption during the previous 3 months was categorized as ≥5, 2-4, or <2 cups per week...
October 3, 2017: Maternal & Child Nutrition
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