Neil A R Gow, Carolyn Johnson, Judith Berman, Alix T Coste, Christina A Cuomo, David S Perlin, Tihana Bicanic, Thomas S Harrison, Nathan Wiederhold, Mike Bromley, Tom Chiller, Keegan Edgar
Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O'Neill report, have predicted that deaths due to drug-resistant bacterial infections may eclipse the total number of cancer deaths by 2050. Although fungal infections remain in the shadow of public awareness, total attributable annual deaths are similar to, or exceeds, global mortalities due to malaria, tuberculosis or HIV. The impact of fungal infections has been exacerbated by the steady rise of antifungal drug resistant strains and species which reflects the widespread use of antifungals for prophylaxis and therapy, and in the case of azole resistance in Aspergillus, has been linked to the widespread agricultural use of antifungals...
September 12, 2022: Nature Communications