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https://www.readbyqxmd.com/read/29140707/grapefruit-flavonoid-naringenin-regulates-the-expression-of-lxr%C3%AE-in-thp-1-macrophages-by-modulating-amp-activated-protein-kinase
#1
Javier Saenz, Consuelo Santa-María, Maria Edith Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Gonzalo Alba
The present work investigates the modulation of grapefruit flavonoid naringenin over Liver X Receptor alpha (LXRα) and its target genes in THP-1 macrophages, focusing on AMP-activated protein kinase (AMPK) implication. Naringenin induced LXRα at mRNA and protein levels besides influencing the expression of LXRα target genes ABCA1, ABCG1 (ATP-binding cassette A1 and G1), and SREBP1c (sterol response element binding protein 1c) in THP-1 macrophages. The increased LXRα mRNA and protein expression was reverted when AMPK was inhibited by its chemical inhibitor, compound C or by transfection with AMPK α1 and α2 siRNA...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29121676/naringin-prevents-hiv-1-protease-inhibitors-induced-metabolic-complications-in-vivo
#2
Sanelisiwe Nzuza, Sindiswa Zondi, Peter M O Owira
BACKGROUND: Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities. OBJECTIVES: The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo. METHODS: Male Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3...
2017: PloS One
https://www.readbyqxmd.com/read/29109957/-gold-pressed-essential-oil-an-essay-on-the-volatile-fragment-from-citrus-juice-industry-by-products-chemistry-and-bioactivity
#3
V N Kapsaski-Kanelli, E Evergetis, A Michaelakis, D P Papachristos, E D Myrtsi, S D Koulocheri, S A Haroutounian
Present essay explores the potentials of Citrus juice industry's by-products as alternative bioactive natural products resources. Four crude Cold Pressed Essential Oils (CPEOs), derived from orange, lemon, grapefruit, and mandarin, were studied. All CPEOs were subjected to water distillation, in order to obtain the volatile fragment, which was further fractionated with respect to distillation period in two parts, concluding to eight samples. These samples along with the four original CPEOs were assessed in relation to their phytochemical content and their repellent and larvicidal properties against Asian Tiger Mosquito...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29109044/target-vs-non-target-analysis-to-determine-pesticide-residues-in-fruits-from-saudi-arabia-and-influence-in-potential-risk-associated-with-exposure
#4
Yolanda Picó, Mohamed A El-Sheikh, Ahmed H Alfarhan, Damià Barceló
The occurrence of pesticide residues in fruits was determined by a target method for 62 analytes and a wide scope screening method against a database of 500 pesticides. Limits of quantification (LOQs) were from 0.5 to 6.3 μg kg(-1) for the target method and from 0.5 to 119 μg kg(-1) for the non-target. Thirty samples: dates, apples, oranges, tangerines, lemons and grapefruits were selected because their high consumption, except lemons and grapefruits that were to cover all citrus fruits. Using the target method, 15 compounds (mostly insecticides and fungicides) out of 62 pesticides (organophosphorus, carbamates, pyrethroids, chloroacetanilides, triazines, triazoles, imidazoles, etc...
November 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29105297/recent-advances-in-understanding-xanthomonas-citri-subsp-citri-pathogenesis-and-citrus-canker-disease-management
#5
Christopher M Ference, Alberto M Gochez, Franklin Behlau, Nian Wang, James H Graham, Jeffrey B Jones
Taxonomic status: Bacteria; Phylum Proteobacteria; Class Gammaproteobacteria; Order Xanthomonadles; Family Xanthomonadaceae; Genus Xanthomonas; Species Xanthomonas citri subsp. citri (Xcc). Host range: Compatible hosts vary in their susceptibility to CC, with grapefruit, lime, and lemon being most susceptible, sweet orange being moderately susceptible, and kumquat and calamondin being among the least susceptible (Gottwald et al., 1993). Microbiological properties: Xcc is a rod-shaped (1.5 - 2.0 X 0.5 - 0.75 µm) gram-negative, aerobic bacterium with a single polar flagellum...
November 4, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29058618/in-silico-analysis-of-the-grapefruit-srnaome-transcriptome-and-gene-regulation-in-response-to-ctv-cdvd-co-infection
#6
Marike Visser, Glynnis Cook, Johan T Burger, Hans J Maree
BACKGROUND: Small RNA (sRNA) associated gene regulation has been shown to play a significant role during plant-pathogen interaction. In commercial citrus orchards co-infection of Citrus tristeza virus (CTV) and viroids occur naturally. METHODS: A next-generation sequencing-based approach was used to study the sRNA and transcriptional response in grapefruit to the co-infection of CTV and Citrus dwarfing viroid. RESULTS: The co-infection resulted in a difference in the expression of a number of sRNA species when comparing healthy and infected plants; the majority of these were derived from transcripts processed in a phased manner...
October 23, 2017: Virology Journal
https://www.readbyqxmd.com/read/29048675/naringenin-inhibits-alcoholic-injury-by-improving-lipid-metabolism-and-reducing-apoptosis-in-zebrafish-larvae
#7
Haiyan Lin, Zhenting Zhou, Weichao Zhong, Peng Huang, Ning Ma, Yuqing Zhang, Chuying Zhou, Yuling Lai, Shaohui Huang, Haiyan An, Xuegang Sun, Lei Gao, Zhiping Lv
Alcoholic liver disease (ALD) includes a spectrum of hepatic abnormalities that range from isolated alcoholic steatosis to steatohepatitis and cirrhosis. Naringenin, a predominant flavanone in grapefruit, increases resistance to oxidative stress and inflammation and protects against multiple organ injury in various animal models. However, the specific mechanisms responsible for protection against alcoholic injury are poorly understood. In the present study, we aimed to investigate the effect of naringenin on alcoholic events and the molecular regulatory mechanisms of naringenin in the liver and whole body of zebrafish larvae following exposure to 350 mmol/l ethanol for 32 h...
September 19, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28982188/does-consumption-of-red-grapefruit-juice-alter-naringenin-concentrations-in-milk-produced-by-breastfeeding-mothers
#8
Ewa Romaszko, Urszula Marzec-Wróblewska, Anna Badura, Adam Buciński
The content of certain ingredients of human milk, such as flavonoids, depend on the types and amounts of plant products consumed and may vary from woman to woman. The aim of the study was to determine to what extent consumption of an average amount of grapefruit juice (250 ml) affected naringenin content in human milk. A total of 14 breastfeeding mothers were included in the study. The subjects remained on a diet with restricted intake of naringenin for a total of five days except on the third day, when they drank a single serving of 250 ml of grapefruit juice...
2017: PloS One
https://www.readbyqxmd.com/read/28982157/genotyping-by-sequencing-reveals-the-interspecific-c-maxima-c-reticulata-admixture-along-the-genomes-of-modern-citrus-varieties-of-mandarins-tangors-tangelos-orangelos-and-grapefruits
#9
Amel Oueslati, Amel Salhi-Hannachi, François Luro, Hélène Vignes, Pierre Mournet, Patrick Ollitrault
The mandarin horticultural group is an important component of world citrus production for the fresh fruit market. This group formerly classified as C. reticulata is highly polymorphic and recent molecular studies have suggested that numerous cultivated mandarins were introgressed by C. maxima (the pummelos). C. maxima and C. reticulata are also the ancestors of sweet and sour oranges, grapefruit, and therefore of all the "small citrus" modern varieties (mandarins, tangors, tangelos) derived from sexual hybridization between these horticultural groups...
2017: PloS One
https://www.readbyqxmd.com/read/28977167/11%C3%AE-hydroxysteroid-dehydrogenase-type-ii-activity-is-affected-by-grapefruit-juice-and-intense-muscular-work
#10
Christopher Kargl, Mohammad Arshad, Fahad Salman, Regina C Schurman, Pedro Del Corral
OBJECTIVE: The enzymatic activity of 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) is key to protecting mineral corticoid receptors from cortisol and has been implicated in blood pressure regulation. Grapefruit juice (GFJ) and acidity are thought to inhibit this enzyme in vitro. This study examines the effect of GFJ and intense exercise on 11β-HSD2 enzyme activity in vivo. SUBJECTS AND METHODS: Eighteen subjects ingested GFJ or apple juice (CON) on separate days prior to reporting to the laboratory in a randomized order...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28975417/effects-of-food-and-grapefruit-juice-on-single-dose-pharmacokinetics-of-blonanserin-in-healthy-chinese-subjects
#11
De-Wei Shang, Zhan-Zhang Wang, Hai-Tang Hu, Yue-Feng Zhang, Xiao-Jia Ni, Hao-Yang Lu, Ming Zhang, Jin-Qing Hu, Chang Qiu, Huan Peng, Ling-Fang Shen, Yu-Guan Wen
PURPOSE: The purpose of this study was to investigate the potential effects of a meal and grapefruit juice on the pharmacokinetics of blonanserin and its metabolite N-desethyl blonanserin in healthy Chinese volunteers. METHODS: This was a single-centre, open-label, fixed-sequence study, where 12 healthy Chinese volunteers received a single dose of 8 mg blonanserin after an overnight fast in period 1 (reference), a high-fat meal during period 2 and with co-administration of 250 mL of grapefruit juice in period 3...
October 3, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28974806/functional-crackers-incorporation-of-the-dietary-fibers-extracted-from-citrus-seeds
#12
Emin Yilmaz, Elif Karaman
Dietary fibers extracted from defatted press meals of orange and grapefruit seeds were used in the production of crackers and the crackers were evaluated for physicochemical, textural, sensory properties, and bioactive compounds. The unexplored fibers (grapes seeds and orange seeds) and wheat fiber were added at 2.9% levels. The effects of incorporation of different fibers on composition and consumer acceptability were evaluated. The textural stability during storage was also monitored. Although there were no significant differences for proximate compositions; fiber contents, antioxidant capacities, and phenolics compositions were significantly higher in the crackers containing orange seeds fiber...
September 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28971609/coffee-inhibition-of-cyp3a4-in%C3%A2-vitro-was-not-translated-to-a-grapefruit-like-pharmacokinetic-interaction-clinically
#13
George K Dresser, Brad L Urquhart, Julianne Proniuk, Alvin Tieu, David J Freeman, John Malcolm Arnold, David G Bailey
Grapefruit can augment oral medication bioavailability through irreversible (mechanism-based) inhibition of intestinal CYP3A4. Supplementary data from our recent coffee-drug interaction clinical study showed some subjects had higher area under the plasma drug concentration - time curve (AUC) and plasma peak drug concentration (Cmax) of the CYP3A4 probe felodipine compared to aqueous control. It was hypothesized that coffee might interact like grapefruit in responsive individuals. Beans from six geographical locations were consistently brewed into coffee that was separated chromatographically to a methanolic fraction for in vitro inhibition testing of CYP3A4 metabolism of felodipine at 1% coffee strength...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28966261/synthesis-of-furanocoumarin-benzofuran-and-coumarin-derivatives-possessing-an-inhibitory-effect-on-human-cyp-and-elucidation-of-the-inhibitory-mechanism
#14
Yuki Yamaguchi
Grapefruit juice (GFJ) consumption has been shown to increase the bioavailability of certain orally administered drugs. The furanocoumarin derivatives Paradisin A and bergamottin, which are present in GFJ, are potent mechanism-based inhibitors of CYP3A4. The primary aim of this work was to synthesize a series of furanocoumarin derivatives with a view to determining the relationship between the structure of the inhibitors and their inhibitory CYP3A4 activity. Furanocoumarin derivatives that were more stable and accessible than the furanocoumarin derivatives in GFJ were prepared, and their ability to inhibit CYP3A4 was examined...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28957226/electrically-tunable-whispering-gallery-mode-microresonator-based-on-a-grapefruit-microstructured-optical-fiber-infiltrated-with-nematic-liquid-crystals
#15
Chengkun Yang, Hao Zhang, Bo Liu, Shiwei Lin, Yuetao Li, Haifeng Liu
An electrically tunable whispering gallery mode (WGM) microresonator based on an HF-etched microstructured optical fiber (MOF) infiltrated with nematic liquid crystals (NLCs) is proposed and experimentally demonstrated. Experimental results indicate that as the peak-to-peak voltage of the applied AC electric field increases from 160 to 220 V, WGM resonance peaks gradually move toward a shorter wavelength region by 0.527 nm with a wavelength sensitivity up to 0.01  nm/V for a TM1691 mode, and the Q-factor for each WGM resonance peak rapidly decreases with the increment of applied electric voltage...
August 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28917370/aromatherapies-using-osmanthus-fragrans-oil-and-grapefruit-oil-are-effective-complementary-treatments-for-anxious-patients-undergoing-colonoscopy-a-randomized-controlled-study
#16
Hideaki Hozumi, Sho Hasegawa, Takazumi Tsunenari, Noriko Sanpei, Yuko Arashina, Kieko Takahashi, Ayako Konnno, Emi Chida, Souichi Tomimatsu
BACKGROUND AND AIMS: Colonoscopy can be painful and uncomfortable. Aromatherapy is often used for the relief of anxiety or discomfort. Recently, it has been reported that olfactory stimulation induces various physiological effects. We investigated the effects of aromatherapy on anxiety and abdominal discomfort during colonoscopy. METHODS: The investigation was carried out using a randomized controlled study. Aromatherapy was performed by vapor diffusion, and each patient was given one of the following treatments: no inhalation (control group), essential-oil-less vapor (vehicle group), lavender oil (lavender group), grapefruit oil (grapefruit group), or Osmanthus fragrans oil (Osmanthus fragrans group)...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28912088/sip-and-spit-or-sip-and-swallow-choice-of-method-differentially-alters-taste-intensity-estimates-across-stimuli
#17
Cordelia A Running, John E Hayes
While the myth of the tongue map has been consistently and repeatedly debunked in controlled studies, evidence for regional differences in suprathreshold intensity has been noted by multiple research groups. Given differences in physiology between the anterior and posterior tongue (fungiform versus foliate and circumvallate papillae) and differences in total area stimulated (anterior only versus whole tongue, pharynx, and epiglottis), small methodological changes (sip and spit versus sip and swallow) have the potential to substantially influence data...
November 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28911545/chemistry-and-health-effects-of-furanocoumarins-in-grapefruit
#18
REVIEW
Wei-Lun Hung, Joon Hyuk Suh, Yu Wang
Furanocoumarins are a specific group of secondary metabolites that commonly present in higher plants, such as citrus plants. The major furanocoumarins found in grapefruits (Citrus paradisi) include bergamottin, epoxybergamottin, and 6',7'-dihydroxybergamottin. During biosynthesis of these furanocoumarins, coumarins undergo biochemical modifications corresponding to a prenylation reaction catalyzed by the cytochrome P450 enzymes with the subsequent formation of furan rings. Because of undesirable interactions with several medications, many studies have developed methods for grapefruit furanocoumarin quantification that include high-performance liquid chromatography coupled with UV detector or mass spectrometry...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904803/comparative-transcriptome-analysis-during-early-fruit-development-between-three-seedy-citrus-genotypes-and-their-seedless-mutants
#19
Shujian Zhang, Qingchun Shi, Ute Albrecht, Robert G Shatters, Ric Stange, Greg McCollum, Shuo Zhang, Chengming Fan, Ed Stover
Identification of genes with differential transcript abundance (GDTA) in seedless mutants may enhance understanding of seedless citrus development. Transcriptome analysis was conducted at three time points during early fruit development (Phase 1) of three seedy citrus genotypes: Fallglo (Bower citrus hybrid (Citrus reticulata×C. reticulata×C. paradisi)×Temple (C. reticulata×C. sinensis)), grapefruit (C. paradisi), Pineapple sweet orange (C. sinensis), and their seedless mutants. Seed abortion in seedless mutants was observed at 26 days post anthesis (Time point 2)...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28904280/food-dependent-exercise-induced-anaphylaxis-due-to-ingestion-of-mikan-citrus-unshiu
#20
Yutaka Tanaka, Marie Sugihara, Shuntaro Tsumagari, Nobue Takamatsu, Kazuyuki Kurihara
A 12-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exercise after meals. Food-dependent exercise-induced anaphylaxis (FDEIAn) was suspected. However, sequential tests of typical foods, including egg, milk, soy, and wheat, in combination with exercise, were all negative.The results of the skin prick test (SPT) for Citrus unshiu and specific IgE test for orange and grapefruit were positive. Although no symptoms were noted after an exercise challenge combined with the ingestion of only Citrus unshiu, an anaphylactic reaction was induced by additional acetyl-salicylic acid...
2017: Arerugī, [Allergy]
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