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https://www.readbyqxmd.com/read/28282783/diospyros-lotus-leaf-and-grapefruit-stem-extract-synergistically-ameliorate-atopic-dermatitis-like-skin-lesion-in-mice-by-suppressing-infiltration-of-mast-cells-in-skin-lesions
#1
Byoung Ok Cho, Denis Nchang Che, Hong Hua Yin, Jae Young Shin, Seon Il Jang
Atopic dermatitis, a chronic relapsing and pruritic inflammation of the skin also thought to be involved in, or caused by immune system destruction is an upsetting health problem due to its continuously increasing incidence especially in developed countries. Mast cell infiltration in atopic dermatitis skin lesions and its IgE-mediated activation releases various cytokines and chemokines that have been implicated in the pathogenesis of atopic dermatitis. This study was aimed at investigating synergistic anti-inflammatory, anti-pruritic and anti-atopic dermatitis effects of Diospyros lotus leaf extract (DLE) and Muscat bailey A grapefruit stem extract (GFSE) in atopic dermatitis-like induced skin lesions in mice...
March 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28221852/pesticide-residue-monitoring-on-south-african-fresh-produce-exported-over-a-6-year-period
#2
M T Mutengwe, L Chidamba, L Korsten
Six years of pesticide residue data from fresh produce destined for the export market were analyzed for the period 2009 to 2014. A total of 37,838 fruit (99.27%) and vegetable (0.73%) data sets analyzed for the presence of 73 pesticides were compared. Pesticides were detected on 56.46% of samples, of which 0.78% had multiple residues. Noncompliances detected were because of the use of unregistered pesticides (0.73%), values that exceeded established maximum residue levels (MRLs) (0.32%), or the combination of values that exceeded MRLs and the use of unregistered pesticide residues (0...
October 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28208243/direct-determination-of-ascorbic-acid-in-a-grapefruit-paving-the-way-for-in-vivo-spectroelectrochemistry
#3
Jesus Garoz-Ruiz, Aranzazu Heras, Alvaro Colina
The study of real samples is more complicated than the study of other systems. However, the inherent advantages of UV-vis absorption spectroelectrochemistry should overcome some difficulties related to direct measurements in complex matrices. For this reason, a singular spectroelectrochemistry device has been fabricated and validated. The novel cell is based on single-walled carbon nanotubes, which are filtered and subsequently press-transferred on a polyethylene terephthalate support using a stencil with a custom design...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208159/two-previously-unknown-phytophthora-species-associated-with-brown-rot-of-pomelo-citrus-grandis-fruits-in-vietnam
#4
Ivana Puglisi, Alessandro De Patrizio, Leonardo Schena, Thomas Jung, Maria Evoli, Antonella Pane, Nguyen Van Hoa, Mai Van Tri, Sandra Wright, Mauritz Ramstedt, Christer Olsson, Roberto Faedda, Gaetano Magnano di San Lio, Santa Olga Cacciola
Two distinct Phytophthora taxa were found to be associated with brown rot of pomelo (Citrus grandis), a new disease of this ancestral Citrus species, in the Vinh Long province, Mekong River Delta area, southern Vietnam. On the basis of morphological characters and using the ITS1-5.8S-ITS2 region of the rDNA and the cytochrome oxidase subunit 1 (COI) as barcode genes, one of the two taxa was provisionally named as Phytophthora sp. prodigiosa, being closely related to but distinct from P. insolita, a species in Phytophthora Clade 9, while the other one, was closely related to but distinct from the Clade 2 species P...
2017: PloS One
https://www.readbyqxmd.com/read/28197590/rats-urinary-metabolomes-reveal-the-potential-roles-of-functional-foods-and-exercise-in-obesity-management
#5
Mohamed A Farag, N M Ammar, T E Kholeif, N S Metwally, N M El-Sheikh, Ludger A Wessjohann, A Z Abdel-Hamid
The complexity of the metabolic changes in obese individuals still presents a challenge for the understanding of obesity-related metabolic disruptions and for obesity management. In this study, a gas chromatography mass spectrometry (GC-MS) based metabolomics approach targeting urine metabolism has been applied to assess the potential roles of functional foods and exercise for obesity management in rats. Male albino rats diagnosed as obese via histopathology and biochemical assays were administered functional foods in common use for obesity management including pomegranate, grapefruit, and red cabbage juice extracts in parallel with swimming exercise...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28196843/changes-in-anthocyanin-production-during-domestication-of-citrus
#6
Eugenio Butelli, Andrés Garcia-Lor, Concetta Licciardello, Giuseppina Las Casas, Lionel Hill, Giuseppe Reforgiato Recupero, Manjunath Keremane, Chandrika Ramadugu, Robert Krueger, Qiang Xu, Xiuxin Deng, Anne-Laure Fanciullino, Yann Froelicher, Luis Navarro, Cathie Martin
Mandarin (C. reticulata), citron (C. medica) and pummelo (C. maxima) are important species of the genus Citrus and parents of the interspecific hybrids that constitute the most familiar commercial varieties of citrus: sweet orange, sour orange, clementine, lemon, lime and grapefruit. Citron produces anthocyanins in its young leaves and flowers, as do species in genera closely related to Citrus, but mandarins do not and pummelo varieties that produce anthocyanins have not been reported. We investigated the activity of the Ruby gene, which encodes a MYB transcription factor controlling anthocyanin biosynthesis, in different accessions of a range of Citrus species and in domesticated cultivars...
February 14, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28174089/controllable-immobilization-of-naringinase-on-electrospun-cellulose-acetate-nanofibers-and-their-application-to-juice-debittering
#7
Weijuan Huang, Yingfei Zhan, Xiaowen Shi, Jiajia Chen, Hongbing Deng, Yumin Du
Electrospinning is a facile method to fabricate nanofibers, in terms of their high specific surface area and porous structure. Electrospun nanofibrous mats are excellent candidates for immobilization of enzymes. In this study, a simple route based on electrospinning and layer-by-layer (LBL) self-assembly processes has been developed to prepared naringinase/alginate multilayer coated electrospun cellulose acetate nanofibers. The content of immobilized naringinase could be tuned by adjusting the number of multilayers...
February 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28157162/evidence%C3%A2-of%C3%A2-some%C3%A2-natural%C3%A2-products%C3%A2-with%C3%A2-antigenotoxic%C3%A2-effects-%C3%A2-part%C3%A2-1-%C3%A2-fruits%C3%A2-and%C3%A2-polysaccharides
#8
REVIEW
Jeannett Alejandra Izquierdo-Vega, José Antonio Morales-González, Manuel SánchezGutiérrez, Gabriel Betanzos-Cabrera, Sara M Sosa-Delgado, María Teresa Sumaya-Martínez, Ángel Morales-González, Rogelio Paniagua-Pérez, Eduardo Madrigal-Bujaidar, Eduardo Madrigal-Santillán
Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known  as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are  involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular  disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive  phytocompounds able to counteract the effects of physical and chemical mutagens...
February 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28134229/-interaction-of-oral-form-anticancer-drugs-with-grapefruit-juice
#9
REVIEW
Magdalena Cholewka-Stafińska, Renata Polaniak, Marek Kardas, Mateusz Grajek, Elżbieta Grochowska-Niedworok
Oral medication (tablets, capsules, suspensions, liquids, etc.) are frequently used in therapy. This may arise due to the fact that oral medication patient can take at home and it reduce the stress associated with taking the drug. On the Polish pharmaceutical market can be observed more frequent registration to trading anticancer drugs in oral form. Is also growing interest about drug interactions with food, but they are still less accented than drug-drug interactions. The results of pharmacokinetic studies on the interaction of drugs used in antineoplastic therapy with food are particularly important because of the characteristics of cancer patients, and a growing number of people suffering from cancer and which may have a problem...
January 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28101344/evaluation-of-pharmacological-relaxation-effect-of-the-natural-product-naringin-on-in-vitro-cultured-airway-smooth-muscle-cells-and-in-vivo-ovalbumin-induced-asthma-balb-c-mice
#10
Yue Wang, Yun Lu, Mingzhi Luo, Xiaohao Shi, Yan Pan, Huilong Zeng, Linhong Deng
Asthma has become a common chronic respiratory disease worldwide and its prevalence is predicted to continue increasing in the next decade, particularly in developing countries. A key component in asthma therapy is to alleviate the excessive bronchial airway narrowing ultimately due to airway smooth muscle contraction, which is often facilitated by a smooth muscle relaxant, such as the β2-adrenergic agonists. Recently, bitter taste receptor (TAS2R) agonists, including saccharin and chloroquine, have been found to potently relax the airway smooth muscle cells (ASMCs) via intracellular Ca(2+) signaling...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28087647/an-additional-phytosanitary-cold-treatment-against-ceratitis-capitata-diptera-tephritidae-in-oroblanco-citrus-fruit
#11
Yoav Gazit, Roy Kaspi
For 'Oroblanco' ('Sweetie'), the sweet seedless pummelo-grapefruit hybrid, when exported from Israel to Japan, the standard cold treatment against Ceratitis capitata (Wied.) (Diptera: Tephritidae) is conducted at ≤ 1.5 °C, for 16 d. In recent years, the transportation means of exported citrus was changed from reefer vessels to individual refrigerated containers, where the fruit bulk is relatively small and may be exposed to temperature fluctuations and to the risk of chilling injuries. To reduce this risk, Israel proposed to Japan to increase the treatment temperature and extend its duration to 2...
January 12, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28080039/using-standing-gold-nanorod-arrays-as-surface-enhanced-raman-spectroscopy-sers-substrates-for-detection-of-carbaryl-residues-in-fruit-juice-and-milk
#12
Fouad K Alsammarraie, Mengshi Lin
In recent years, there have been increasing concerns about pesticide residues in various foods. On the other hand, there is growing attention in utilizing novel nanomaterials as highly sensitive, low-cost, and reproducible substrates for surface-enhanced Raman spectroscopy (SERS) applications. The objective of this study was to develop a SERS method for the rapid detection of pesticides that were extracted from different types of food samples (fruit juice and milk). A new SERS substrate was prepared by assembling gold nanorods into standing arrays on a gold-coated silicon slide...
January 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28063510/converting-citrus-wastes-into-value-added-products-economic-and-environmently-friendly-approaches
#13
REVIEW
Kavita Sharma, Neelima Mahato, Moo Hwan Cho, Yong Rok Lee
Citrus fruits, including oranges, grapefruits, lemons, limes, tangerines, and mandarins, are among the most widely cultivated fruits around the globe. Its production is increasing every year due to rising consumer demand. Citrus-processing industries generate huge amounts of wastes every year, and citrus peel waste alone accounts for almost 50% of the wet fruit mass. Citrus waste is of immense economic value as it contains an abundance of various flavonoids, carotenoids, dietary fiber, sugars, polyphenols, essential oils, and ascorbic acid, as well as considerable amounts of some trace elements...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28032362/prioritizing-pharmacokinetic-drug-interaction-precipitants-in-natural-products-application-to-oatp-inhibitors-in-grapefruit-juice
#14
Emily J Johnson, Christina S Won, Kathleen Köeck, Mary F Paine
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation...
December 29, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28030637/quality-matters-influences-of-citrus-flush-physicochemical-characteristics-on-population-dynamics-of-the-asian-citrus-psyllid-hemiptera-liviidae
#15
Mamoudou Sétamou, Catherine R Simpson, Olufemi J Alabi, Shad D Nelson, Srilakshmi Telagamsetty, John L Jifon
Studies were conducted to relate the influence of the physical characteristics, leaf nutrient content and phloem sap amino acid concentration of citrus flush shoots on the densities of various Diaphorina citri life stages. Adult D. citri preferentially selected young shoots for feeding and numbers of D. citri immatures were positively correlated with flush shoot softness. Young flush shoots had higher concentrations of macro and micro nutrients relative to mature ones and this was associated with higher densities of all D...
2016: PloS One
https://www.readbyqxmd.com/read/27936512/genome-editing-of-the-disease-susceptibility-gene-cslob1-in-citrus-confers-resistance-to-citrus-canker
#16
Hongge Jia, Yunzen Zhang, Vladimir Orbovic, Jin Xu, Frank White, Jeffrey Jones, Nian Wang
Citrus is a highly valued tree crop worldwide, while, at the same time, citrus production faces many biotic challenges, including bacterial canker and Huanglongbing (HLB). Breeding for disease resistant varieties is the most efficient and sustainable approach to control plant diseases. Traditional breeding of citrus varieties is challenging due to multiple limitations, including polyploidy, polyembryony, extended juvenility, and long crossing cycles. Targeted genome editing technology has the potential to shorten varietal development for some traits, including disease resistance...
December 9, 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/27933902/3-sulfanyl-4-methylpentan-1-ol-in-dry-hopped-beers-first-evidence-of-glutathione-s-conjugates-in-hop-humulus-lupulus-l
#17
Marie-Lucie Kankolongo Cibaka, Laura Decourrière, Celso-José Lorenzo-Alonso, Etienne Bodart, Raphaël Robiette, Sonia Collin
Monovarietal dry-hopped beers were produced with the dual-purpose hop cultivars Amarillo, Hallertau Blanc, and Mosaic. The grapefruit-like 3-sulfanyl-4-methylpentan-1-ol was found in all three beers at concentrations much higher than expected on the basis of the free thiol content in hop. Even cysteinylated precursors proved unable to explain our results. As observed in wine, the occurrence of S-glutathione precursors was therefore suspected in hop. The analytical standards of S-3-(4-methyl-1-hydroxypentyl)glutathione, never described before, and of S-3-(1-hydroxyhexyl)glutathione, previously evidenced in grapes, were chemically synthesized...
November 16, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27921450/oral-pharmacokinetic-interaction-of-ester-rich-fruit-juices-and-pharmaceutical-excipients-with-tenofovir-disoproxil-fumarate-in-male-wistar-rats
#18
Joseph Shailender, Punna Rao Ravi, Paramita Saha, Srividya Myneni
1. The aim of this study was to evaluate the role of intestinal esterases on the absorption process of tenofovir disoproxil fumarate (TDF). 2. The esterase inhibition capacity of fruit juices (FJs) rich in ester linkages and pharmaceutical excipients (having ester bonds) was performed in vitro by incubating TDF with each FJ and excipient in the intestinal washings. The ex vivo everted gut sac model was also used to evaluate the absorption enhancement capacity of these FJs and excipients. Single-dose oral pharmacokinetic studies were performed by concomitant administration of TDF with each of the selected FJs and excipients...
January 12, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27904048/inhibitory-effect-of-hesperetin-and-naringenin-on-human-udp-glucuronosyltransferase-enzymes-implications-for-herb-drug-interactions
#19
Dan Liu, Jie Wu, Hongbo Xie, Mingyi Liu, Isaiah Takau, Hong Zhang, Yuqing Xiong, Chunhua Xia
Hesperetin (HET) and naringenin (NGR) are flavanones found in citrus (oranges and grapefruit) and Aurantii Fructus Immaturus. The present study aims to investigate the inhibition potential of HET and NGR derivatives towards one of the most important phase II drug-metabolizing enzymes-uridine diphosphate (UDP)-glucuronosyltransferases (UGTs). We used trifluoperazine as a probe substrate to test UGT1A4 activity, and recombinant UGT-catalyzed 4-methylumbelliferone glucuronidation was used as a probe reaction for other UGT isoforms...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27890698/clementine-juice-has-the-potential-for-drug-interactions-in-vitro-comparison-with-grapefruit-and-mandarin-juice
#20
Dirk Theile, Nicolas Hohmann, Dominik Kiemel, Giuseppe Gattuso, Davide Barreca, Gerd Mikus, Walter Emil Haefeli, Vedat Schwenger, Johanna Weiss
Adverse drug interactions due to grapefruit juice are well known prompting warnings even in drug labels. Similar issues have not been reported for clementines and available data is scarce, despite of genetic descent. We observed substantially increased tacrolimus trough concentrations in a renal transplant patient consuming high clementine amounts and, thus, scrutinised the effects of clementine juice on drug metabolism and drug transporters in vitro and compared it to the effects of mandarin and grapefruit juice...
January 15, 2017: European Journal of Pharmaceutical Sciences
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