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https://www.readbyqxmd.com/read/29746162/antifungal-activity-of-essential-oils-against-azole-resistant-and-azole-susceptible-i-i-candida-glabrata-i-i-strains-vaginal-isolates
#1
Nadia Massa, Simone Cantamessa, Giorgia Novello, Elia Ranzato, Simona Martinotti, Matteo Pavan, Andrea Rocchetti, Graziella Berta, Elisa Gamalero, Elisa Bona
<i></i>Candida glabrata<i></i> is an opportunistic pathogen, associated with endocarditis, meningitis and disseminated disease and also with complicated vaginitis. Essential oils derived from aromatic plants are known in traditional medicine as antimicrobial agents and have antifungal properties. The aim of this work was to evaluate whether the twelve tested essential oils (tea tree, laurel, anise, basil, bergamot, lavender, mint, oregano, grapefruit, rosemary, winter savory and ginger) could have a transverse effect on <i></i>C...
May 10, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29729020/preservative-efficacy-of-selected-antimicrobials-of-natural-origin-in-a-cosmetic-emulsion
#2
Nina Kočevar Glavač, Mojca Lunder
OBJECTIVE: To investigate the efficacy of 13 antimicrobial substances (11 substances of natural origin and two conventional preservatives as controls) at two concentrations in an o/w cosmetic emulsion. METHODS: Cosmetic formulations were analysed for total aerobic bacterial count and total combined yeast count according to the European Pharmacopoeia 8.0. Challenge tests were performed according to the ISO 11930 standard. RESULTS: The total aerobic bacterial count, the total combined yeast count and the total aerobic mesophilic microorganisms were below the acceptable limit for all cosmetic formulations...
May 5, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29724647/preparation-characterization-and-application-of-polymethacrylate-based-monolithic-columns-for-fast-and-efficient-separation-of-alkanes-alcohols-alkylbenzenes-and-isomeric-mixtures-by-gas-chromatography
#3
Munir S Obbed, Ahmad Aqel, Z A Al Othman, A-Yacine Badjah-Hadj-Ahmed
Application of monolithic columns in gas chromatography is still considered very limited. In this work, several polymethacrylate-based monolithic capillary columns were fabricated, characterized and used in gas chromatography. The five monomers used were: methyl methacrylate, (MMA), hexyl methacrylate (HMA), glycidyl methacrylate (GMA), 2-butoxyethyl methacrylate (BEMA) and isobornyl methacrylate (IBMA), while ethylene dimethacrylate was the crosslinker. The monoliths were synthesized in 30 cm length capillaries possessing inner diameters (i...
April 23, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29721568/hepatoprotection-of-auraptene-from-peels-of-citrus-fruits-against-thioacetamide-induced-hepatic-fibrosis-in-mice-by-activating-farnesoid-x-receptor
#4
Xiaoguang Gao, Changyuan Wang, Chenqing Ning, Kexin Liu, Xinyuan Wang, Zhihao Liu, Huijun Sun, Xiaodong Ma, Pengyuan Sun, Qiang Meng
Hepatic fibrosis is a pathological process that eventually leads to the development of cirrhosis and liver cancer by various types of chronic liver disease. To date, there is no standard treatment for the progression of liver fibrosis. This study aims to investigate the hepatoprotection of auraptene (AUR), a simple coumarin contained in the peels of citrus fruits such as grapefruit, against thioacetamide (TAA)-induced hepatic fibrosis in mice. The involvement of farnesoid X receptor (FXR) in the anti-fibrotic effect of AUR was further elucidated using in vivo and in vitro experiments...
May 3, 2018: Food & Function
https://www.readbyqxmd.com/read/29716013/high-spatial-resolution-ultrasonic-sensor-using-a-micro-suspended-core-fiber
#5
Zhihua Shao, Qiangzhou Rong, Fengyi Chen, Xueguang Qiao
A high-resolution fiber-optic ultrasonic sensor based on a suspended-core fiber was designed and experimentally demonstrated. The intrinsic Fabry-Perot interferometer consisting of a micro suspended-core from acid corrosion of a grapefruit fiber proved highly sensitive to a wide range of ultrasonic wave (UW) frequencies. A compact interrogation system using spectral sideband filtering was constructed for UW detection. The sensor exhibited significantly improved spatial resolution and detection sensitivity by etching the suspended-core diameter to few microns...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29703387/food-drug-interactions-precipitated-by-fruit-juices-other-than-grapefruit-juice-an-update-review
#6
REVIEW
Meng Chen, Shu-Yi Zhou, Erlinda Fabriaga, Pian-Hong Zhang, Quan Zhou
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29692750/intake-of-raw-fruits-and-vegetables-is-associated-with-better-mental-health-than-intake-of-processed-fruits-and-vegetables
#7
Kate L Brookie, Georgia I Best, Tamlin S Conner
Background: Higher intakes of fruits and vegetables, rich in micronutrients, have been associated with better mental health. However, cooking or processing may reduce the availability of these important micronutrients. This study investigated the differential associations between intake of raw fruits and vegetables, compared to processed (cooked or canned) fruits and vegetables, and mental health in young adults. Methods: In a cross-sectional survey design, 422 young adults ages 18-25 (66.1% female) living in New Zealand and the United States completed an online survey that assessed typical consumption of raw vs...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29684853/naringenin-improve-hepatitis-c-virus-infection-induced-insulin-resistance-by-increase-pten-expression-via-p53-dependent-manner
#8
Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29666611/genome-sequence-assembly-and-characterization-of-two-metschnikowia-fructicola-strains-used-as-biocontrol-agents-of-postharvest-diseases
#9
Edoardo Piombo, Noa Sela, Michael Wisniewski, Maria Hoffmann, Maria L Gullino, Marc W Allard, Elena Levin, Davide Spadaro, Samir Droby
The yeast Metschnikowia fructicola was reported as an efficient biological control agent of postharvest diseases of fruits and vegetables, and it is the bases of the commercial formulated product "Shemer." Several mechanisms of action by which M. fructicola inhibits postharvest pathogens were suggested including iron-binding compounds, induction of defense signaling genes, production of fungal cell wall degrading enzymes and relatively high amounts of superoxide anions. We assembled the whole genome sequence of two strains of M...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29652818/beneficial-effects-of-different-flavonoids-on-vascular-and-renal-function-in-l-name-hypertensive-rats
#10
M Dolores Paredes, Paola Romecín, Noemí M Atucha, Francisco O'Valle, Julián Castillo, M Clara Ortiz, Joaquín García-Estañ
BACKGROUND: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. METHODS: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. RESULTS: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29648949/induced-systemic-resistance-against-citrus-canker-disease-by-rhizospheric-bacteria
#11
Nadia Riera, Han Wang, Yong Li, Jinyun Li, Kirsten Pelz-Stelinski, Nian Wang
Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is an important citrus disease that causes significant economic losses worldwide. All commercial citrus varieties are susceptible to citrus canker. Currently, chemical control with copper based products is the main approach to control Xcc dispersal and plant colonization. However, extensive use of copper compounds can result in copper-resistant strains and cause adverse effects on the environment. Alternatives to chemical control involve the activation of citrus immunity to control the disease...
April 12, 2018: Phytopathology
https://www.readbyqxmd.com/read/29614883/bergamottin-inhibits-adipogenesis-in-3t3-l1-cells-and-weight-regulation-in-diet-induced-obese-mice
#12
Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Kwang Seok Ahn
Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it. Bergamottin (BGM), a component of grapefruit juice, has been reported to regulate lipolysis. However, the physiological role of BGM in obesity has not been evaluated so far. In the present study, we investigated the effects of BGM on obesity in 3T3-L1 cells and in mice fed a high-fat diet (HFD). BGM inhibited adipogenic differentiation of 3T3-L1 cells along with a significant decrease in the lipid content by downregulating the expression of two critical adipogenic factors, CCAAT enhancer-binding protein-alpha (C/EBP[Formula: see text]) and peroxisome proliferator activated receptor-gamma (PPAR[Formula: see text])...
April 4, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29574996/effect-of-nahco-3-treatments-on-the-activity-of-cell-wall-degrading-enzymes-produced-by-penicillium-digitatum-during-the-pathogenesis-process-on-grapefruit
#13
Tullio Venditti, Guy D'hallewin, Gianfranca Ladu, Giacomo L Petretto, Giorgio Pintore, John M Labavitch
BACKGROUND: The present study was performed to clarify the strategies of Penicillium digitatum during pathogenesis on citrus, assessing, on albedo plugs, the effects of treatment with NaHCO3 , at two different pH (5 and 8.3), on cell wall-degrading enzymes activity, over a period of 72 h. RESULTS: The treatment with NaHCO3 , under alkaline pH, delayed the polygalacturonase activity for 72 h, or 48 h in the case of the pectin lyase, if compared to the control or the same treatment at pH 5...
March 25, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29566693/potentiating-and-synergistic-effect-of-grapefruit-juice-on-the-antioxidant-and-anti-inflammatory-activity-of-aripiprazole-against-hydrogen-peroxide-induced-oxidative-stress-in-mice
#14
Seema Zargar, Abdul-Rahman A Al-Majed, Tanveer A Wani
BACKGROUND: Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice having high concentration of polyphenols might potentiate and synergize the therapeutic effect of ARI, by increasing its bioavailability and inherent antioxidant potential. These benefits together might decrease the daily dosage of the ARI and thus alleviate the possible side effects of drug...
March 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29561242/fertaric-acid-protects-from-octylphenol-related-hepatotoxicity-in-rats-biochemical-molecular-and-histopathological-studies
#15
Khaled M M Koriem, Mahmoud S S Arbid
The endocrine-disrupting chemical 4-tert-octylphenol (OP) can mimic estrogen and testosterone hormones and threaten health; fertaric acid (FA) is a hydroxycinnamic acid found in grapefruit. This study aimed to investigate whether FA has a protective effect on 4-tert-octylphenol-related hepatotoxicity. Thirty male albino rats were divided into 5 equal groups of 6 rats each as follows: control group-administrated orally with 1 ml saline 3 days/week for 4 weeks; corn oil group-administrated orally with 1 ml corn oil 3 days/week for 4 weeks; FA-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks; OP-treated group-administrated orally with OP (40 mg /kg body weight) dissolved in corn oil 3 days/week for 4 weeks; FA + OP-treated group-administrated orally with FA (45 mg /kg body weight) dissolved in saline 3 days/week for 4 weeks then administrated orally with OP (40 mg/kg body weight) dissolved in corn oil 3 days/week for another 4 weeks...
March 21, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29509801/selective-biosorption-of-thorium-iv-from-aqueous-solutions-by-ginkgo-leaf
#16
Yaoyao Huang, Yang Hu, Lvcun Chen, Tao Yang, Hanfang Huang, Runping Shi, Peng Lu, Chenghua Zhong
Low-cost biosorbents (ginkgo leaf, osmanthus leaf, banyan leaf, magnolia leaf, holly leaf, walnut shell, and grapefruit peel) were evaluated in the simultaneous removal of La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Yb3+, Lu3+, UO22+, Th4+, Y3+, Co2+, Zn2+, Ni2+, and Sr2+ from aqueous solutions. In single metal systems, all adsorbents exhibited good to excellent adsorption capacities toward lanthanides and actinides. In a simulated multicomponent mixed solution study, higher selectivity and efficiency were observed for Th4+ over other metal cations, with ginkgo leaves providing the highest adsorptivity (81...
2018: PloS One
https://www.readbyqxmd.com/read/29508393/optimization-of-ultrasound-assisted-extraction-of-phenolic-compounds-from-grapefruit-citrus-paradisi-macf-leaves-via-d-optimal-design-and-artificial-neural-network-design-with-categorical-and-quantitative-variables
#17
Zeynep Ciğeroğlu, Ömür Aras, Carlos A Pinto, Mahmut Bayramoglu, Ş İsmail Kırbaşlar, José M Lorenzo, Francisco J Barba, Jorge A Saraiva, Selin Şahin
BACKGROUND: The extraction of phenolic compounds from grapefruit leaves assisted by ultrasound-assisted extraction (UAE) was optimized using response surface methodology (RSM) by means of D-optimal experimental design and artificial neural network (ANN). For this purpose, five numerical factors were selected: ethanol concentration (0-50%), extraction time (15-60 min), extraction temperature (25-50 °C), solid:liquid ratio (50-100 g L-1 ) and calorimetric energy density of ultrasound (0...
March 6, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29495362/in-vivo-protective-effects-of-nootkatone-against-particles-induced-lung-injury-caused-by-diesel-exhaust-is-mediated-via-the-nf-%C3%AE%C2%BAb-pathway
#18
Abderrahim Nemmar, Suhail Al-Salam, Sumaya Beegam, Priya Yuvaraju, Naserddine Hamadi, Badreldin H Ali
Numerous studies have shown that acute particulate air pollution exposure is linked with pulmonary adverse effects, including alterations of pulmonary function, inflammation, and oxidative stress. Nootkatone, a constituent of grapefruit, has antioxidant and anti-inflammatory effects. However, the effect of nootkatone on lung toxicity has not been reported so far. In this study we evaluated the possible protective effects of nootkatone on diesel exhaust particles (DEP)-induced lung toxicity, and the possible mechanisms underlying these effects...
February 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29483818/olfactory-stimulation-modulates-the-blood-glucose-level-in-rats
#19
Tadataka Tsuji, Susumu Tanaka, Sanam Bakhshishayan, Mikihiko Kogo, Takashi Yamamoto
In both humans and animals, chemosensory stimuli, including odors and tastes, induce a variety of physiologic and mental responses related to energy homeostasis, such as glucose kinetics. The present study examined the importance of olfactory function in glucose kinetics following ingestion behavior in a simplified experimental scenario. We applied a conventional glucose tolerance test to rats with and without olfactory function and analyzed subsequent blood glucose (BG) curves in detail. The loss of olfactory input due to experimental damage to the olfactory mucosa induced a marked decrease in the area under the BG curve...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29461671/functional-characterization-of-the-citrus-canker-susceptibility-gene-cslob1
#20
Shuo Duan, Hongge Jia, Zhiqian Pang, Doron Teper, Frank White, Jeffrey Jones, Changyong Zhou, Nian Wang
Xanthomonas citri ssp. citri (Xcc) is an important plant-pathogenic bacterium that causes citrus canker disease worldwide. PthA, a transcriptional activator-like (TAL) effector, directs the expression of the canker susceptibility gene CsLOB1. Here, we report our recent progress in the functional characterization of CsLOB1. Subcellular localization analysis of CsLOB1 protein in citrus protoplast revealed that CsLOB1 is primarily localized in the nucleus. We showed that CsLOB1 expression driven by dexamethasone (DEX) in CsLOB1-GR transgenic plants is associated with pustule formation following treatment with DEX...
February 20, 2018: Molecular Plant Pathology
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