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JOURNAL ARTICLE
Mengting Zhao, Xia Jiang, Jingwen Fang, Ye Lin, Youhong Li, Renzhi Pei, Peipei Ye, Ying Lu, Lei Jiang
BACKGROUND: B-cell lymphoma, which originates from B cells at diverse differentiation stages, is the most common non-Hodgkin lymphoma with tremendous treatment challenges and unsatisfactory clinical outcomes. Flavokawain B (FKB), a naturally occurring chalcone extracted from kava, possesses promising anticancer properties. However, evidence on the effects of FKB on hematological malignancies, particularly lymphomas, remains scarce. PURPOSE: This study aimed to investigate the antilymphoma effect of FKB and its underlying mechanisms...
September 7, 2023: Phytomedicine
#22
JOURNAL ARTICLE
Arthur Stefanski, Eduardo Pérez-Palma, Tobias Brünger, Ludovica Montanucci, Cornelius Gati, Chiara Klöckner, Katrine M Johannesen, Kimberly Goodspeed, Marie Macnee, Alexander T Deng, Ángel Aledo-Serrano, Artem Borovikov, Maina Kava, Arjan M Bouman, M J Hajianpour, Deb K Pal, Marc Engelen, Eveline E O Hagebeuk, Marwan Shinawi, Alexis R Heidlebaugh, Kathryn Oetjens, Trevor L Hoffman, Pasquale Striano, Amanda S Freed, Line Futtrup, Thomas Balslev, Anna Abulí, Leslie Danvoye, Damien Lederer, Tugce Balci, Maryam Nabavi Nouri, Elizabeth Butler, Sarah Drewes, Kalene van Engelen, Katherine B Howell, Jean Khoury, Patrick May, Marena Trinidad, Steven Froelich, Johannes R Lemke, Jacob Tiller, Amber N Freed, Jing-Qiong Kang, Arthur Wuster, Rikke S Møller, Dennis Lal
Genetic variants in the SLC6A1 gene can cause a broad phenotypic disease spectrum by altering the protein function. Thus, systematically curated clinically relevant genotype-phenotype associations are needed to understand the disease mechanism and improve therapeutic decision-making. We aggregated genetic and clinical data from 172 individuals with likely pathogenic/pathogenic (lp/p) SLC6A1 variants and functional data for 184 variants (14.1% lp/p). Clinical and functional data were available for a subset of 126 individuals...
August 30, 2023: Brain
#23
JOURNAL ARTICLE
Raymond A Ruiz, Keren Lehavot, Jaimee L Heffner, Christine M Kava, India J Ornelas
PURPOSE: To examine differences across gender and sexual orientation in cigarette smoking motives and stages of change in smoking cessation among Veterans. DESIGN: Secondary data analysis of cross-sectional baseline surveys from a prospective cohort study. SETTING: United States, self-administered online survey. PARTICIPANTS: Cisgender Veterans who reported past-year smoking (N = 146); 66.4% identified as lesbian, gay, or bisexual and 52...
August 29, 2023: American Journal of Health Promotion: AJHP
#24
JOURNAL ARTICLE
Christine M Kava, Michelle Strait, Katie Treend, Thuy Vu, Peggy A Hannon, Jeffrey R Harris
OBJECTIVE: To explore tobacco-related knowledge and perceptions at Washington State (WA) agencies. METHODS: Cross-sectional employee survey and qualitative focus groups with managers/supervisors. We produced descriptive statistics to examine differences in awareness and perceptions of tobacco-control efforts among employees and conducted a rapid thematic analysis of focus group data. RESULTS: Of employees, only 18% with a history of tobacco use had utilized their agency's cessation benefits...
August 28, 2023: Journal of Occupational and Environmental Medicine
#25
JOURNAL ARTICLE
Emre Leventoğlu, Bahar Büyükkaragöz, Furkan Çağrı Kavas, Mert Can Holoğlu, Akif Kavgacı, Kibriya Fidan, Aydın Dalgıç, Sevcan A Bakkaloğlu, Fatma Sedef Tunaoğlu, Oğuz Söylemezoğlu
Cardiovascular diseases are the main causes of morbidity in children with chronic kidney disease (CKD). Electrocardiography (ECG) can provide important information about cardiac functions and parameters associated with sudden cardiac death. This study aims to evaluate the potentially dangerous changes in CKD and kidney replacement therapies by ECG and to determine the value of ECG in predicting cardiovascular outcome compared with echocardiography. 101 patients with CKD were divided into subgroups according to treatment modalities as pre-dialysis CKD, hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation (KTx)...
November 2023: European Journal of Pediatrics
#26
JOURNAL ARTICLE
Ting Xiao, Dandi Gao, Xiaoting Gu, Yanping Zhang, Yuxin Zhu, Zihui Zhang, Yiming He, Luqing Wei, Hongli Li, Honggang Zhou, Cheng Yang
Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease characterized by myofibroblast proliferation and extracellular matrix deposition that has a high mortality rate and limited therapeutic options. Flavokawain A(FKA) is the major component of chalcone in kava extract. FKA has been reported to inhibit TGF-β1-induced cardiomyocyte fibrosis by suppressing ROS production in A7r5 cells, but the role and mechanism of FKA in pulmonary fibrosis are unknown. In this study, we evaluated the effect of FKA on pulmonary fibrosis using an animal model of bleomycin-induced pulmonary fibrosis and showed that FKA alleviated the development of pulmonary fibrosis in a dose-dependent manner and improved lung function as well as collagen deposition and extracellular matrix accumulation in mice...
August 12, 2023: European Journal of Pharmacology
#27
JOURNAL ARTICLE
Jamie Thomas, Shrikanth Atluri, Isaac Zucker, Isildinha Reis, Deukwoo Kwon, Eric Kim, Ashutosh Tewari, Vipul Patel, Vinayak Wagaskar, Badrinath Konety, Ali Kasraeian, Stefan Czarniecki, Gregory Thoreson, Nachiketh Soodana-Prakash, Chad Ritch, Bruno Nahar, Mark Gonzalgo, Bruce Kava, Dipen Parekh, Sanoj Punnen
OBJECTIVE: Prostate magnetic resonance imaging (MRI) and biomarkers are often used in conjunction to enhance the selection process for prostate biopsy. However, the optimal sequence of ordering these tests has not been established. A comprehensive evaluation was conducted on a large multi-institutional cohort of patients who underwent MRI, 4K score, and biopsy of the prostate to examine the impact of utilizing both tests vs. either test alone and to determine if the order in which these tests are administered affects the ability to detect clinically significant prostate cancer (csCaP)...
August 4, 2023: Urologic Oncology
#28
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 7, 2023: Medical Letter on Drugs and Therapeutics
#29
JOURNAL ARTICLE
Zhe Wei, Xia Gu, Jinrui Zhang, Yuan Chen, Tao Jiang, Daifeng Hu, Mengyue Miao, Hui Zhou, Rui Cheng, Alexander Tobias Teichmann, Youzhe Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Shrub kava has long been grown and utilized, primarily in the South Pacific region, for ceremonial, religious, and social occasions. It has been used as a pain reliever and muscle relaxant in medicinal practices from eighteenth century. Interestingly, relatively low incidence of lung cancer may attribute to the high consumption of kava products in this region. AIM OF THE STUDY: Kava extracts were used to produce the kava chalcones Flavokawain A, B and C, which have a variety of bioactivities...
July 10, 2023: Journal of Ethnopharmacology
#30
JOURNAL ARTICLE
Aslıhan Kurt-Kızıldoğan, Çiğdem Otur, Kubilay Yıldırım, Musa Kavas, Büşra Abanoz-Seçgin
Fungal bioremediation is a very attractive tool to cope with environmental pollution. We aimed to decipher the cadmium (Cd) response of Purpureocillium sp. CB1, isolated from polluted soil, at transcriptome level by RNA-sequencing (RNA-seq). We used 500 and 2500 mg/L of Cd2+ concentrations at two time points (t6;36 ). RNA-seq determined 620 genes that were co-expressed in all samples. The highest number of differentially expressed genes (DEGs) was obtained within the first six h of exposure to 2500 mg/L of Cd2+ ...
July 12, 2023: Applied Microbiology and Biotechnology
#31
JOURNAL ARTICLE
Hatice Genç Kavas, Ahmet Şengönül
OBJECTIVE: The COVID-19 pandemic and related deaths affected the number of admissions of patients to hospitals. However, no study has been found that examines the short and long-term psychological effects of children or their possible psychiatric admissions to hospitals during the pandemic period. In this context, the study aims to analyze the behaviors of individuals under the age of 18 in their health service utilization during the COVID-19 pandemic period. MATERIALS AND METHOD: For the study, whether the pandemic and psychiatry department (PSY) admissions affect the pediatrics department (PD) and pediatric emergency department (PED) admissions of children was investigated...
June 2023: Eurasian Journal of Medicine
#32
Fei-Yi Zhao, Peijie Xu, Gerard A Kennedy, Russell Conduit, Wen-Jing Zhang, Yan-Mei Wang, Qiang-Qiang Fu, Zhen Zheng
BACKGROUND: There is a need for evidence-informed guidance on the use of complementary and alternative medicine (CAM) for insomnia because of its widespread utilization and a lack of guidance on the balance of benefits and harms. This systematic review aimed to identify and summarize the CAM recommendations associated with insomnia treatment and care from existing comprehensive clinical practice guidelines (CPGs). The quality of the eligible guidelines was appraised to assess the credibility of these recommendations...
2023: Frontiers in Public Health
#33
REVIEW
Yuan Gong, Zhuan-Ning Shi, Jun Yu, Xiao-Feng He, Xian-Hua Meng, Quan-Xiang Wu, Ying Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Scorzonera L. comprises of approximately 175 species, which are mainly distributed in temperate and arid regions of Central Europe, Central Asia, and Africa. Twenty-nine Scorzonera traditional ethnomedicines have been used for treating colds and fevers, pulmonary diseases, asthma, dyspepsia, malignant stomach neoplasia, liver disorder, jaundice, kidney diseases, mastitis, women's vaginitis, herpes zoster, poisonous ulcers, rheumatic pain, diabetic, atherosclerosis, headache, hypertension, dysentery, pregnant vomiting, snakebites, etc...
June 28, 2023: Journal of Ethnopharmacology
#34
REVIEW
Teodoro Cardi, Jana Murovec, Allah Bakhsh, Justyna Boniecka, Tobias Bruegmann, Simon E Bull, Tom Eeckhaut, Matthias Fladung, Vladislava Galovic, Anna Linkiewicz, Tjasa Lukan, Isabel Mafra, Krzysztof Michalski, Musa Kavas, Alessandro Nicolia, Justyna Nowakowska, Laszlo Sági, Cecilia Sarmiento, Kubilay Yıldırım, Milica Zlatković, Goetz Hensel, Katrijn Van Laere
The discovery of the CRISPR/Cas genome-editing system has revolutionized our understanding of the plant genome. CRISPR/Cas has been used for over a decade to modify plant genomes for the study of specific genes and biosynthetic pathways as well as to speed up breeding in many plant species, including both model and non-model crops. Although the CRISPR/Cas system is very efficient for genome editing, many bottlenecks and challenges slow down further improvement and applications. In this review we discuss the challenges that can occur during tissue culture, transformation, regeneration, and mutant detection...
June 16, 2023: Trends in Plant Science
#35
REVIEW
Breanne Freeman, Jessica Mamallapalli, Tengfei Bian, Kayleigh Ballas, Allison Lynch, Alexander Scala, Zhiguang Huo, Kristianna M Fredenburg, Adriaan W Bruijnzeel, Carolyn J Baglole, Junxuan Lu, Ramzi G Salloum, John Malaty, Chengguo Xing
Lung cancer is the leading cause of cancer-related deaths due to its high incidence, late diagnosis, and limited success in clinical treatment. Prevention therefore is critical to help improve lung cancer management. Although tobacco control and tobacco cessation are effective strategies for lung cancer prevention, the numbers of current and former smokers in the USA and globally are not expected to decrease significantly in the near future. Chemoprevention and interception are needed to help high-risk individuals reduce their lung cancer risk or delay lung cancer development...
May 31, 2023: International Journal of Molecular Sciences
#36
JOURNAL ARTICLE
Serdar Kaymaz, Murat Kavas, Aydın Demiray, Uğur Karasu, Veli Çobankara, Sibel Boğa
OBJECTIVES: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis. PATIENTS AND METHODS: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5±9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9±5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms...
March 2023: Archives of Rheumatology
#37
JOURNAL ARTICLE
Gulfem Elif Celik, Omur Aydin, Derya Gokmen, Gozde Koycu Buhari, Zeynep Celebi Sozener, Bilun Gemicioglu, Ismet Bulut, Sengul Beyaz, Cihan Orcen, Secil Kepil Ozdemir, Metin Keren, Ebru Damadoglu, Tugce Yakut, Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim, Insu Yilmaz, Ilkay Koca Kalkan, Mehmet Atilla Uysal, Elif Yelda Ozgun Niksarlioglu, Ali Fuat Kalyoncu, Gul Karakaya, Muge Erbay, Sibel Nayci, Fatma Merve Tepetam, Asli Akkor Gelincik, Hulya Dirol, Ozlem Goksel, Selen Karaoglanoglu, Ferda Oner Erkekol, Sacide Rana Isik, Fusun Yildiz, Yasemin Yavuz, Dilek Karadogan, Nurgul Bozkurt, Ummuhan Seker, Ipek Kivilcim Oguzulgen, Ilknur Basyigit, Serap Argun Baris, Elif Yilmazel Ucar, Tuba Erdogan, Mehmet Polatli, Dane Ediger, Fatma Esra Gunaydin, Murat Turk, Leyla Pur, Zeynep Yegin Katran, Yonca Sekibag, Enes Furkan Aykac, Dilsad Mungan, Ozcan Gul, Ali Cengiz, Bulent Akkurt, Seyma Ozden, Semra Demir, Derya Unal, Ayse Feyza Aslan, Ali Can, Reyhan Gumusburun, Gulhan Bogatekin, Hatice Serpil Akten, Sinem Inan, Munevver Erdinc, Aliye Candan Ogus, Murat Kavas, Demet Polat Yulug, Mehmet Erdem Cakmak, Saltuk Bugra Kaya, Gulistan Alpagat, Eylem Sercan Ozgur, Oguz Uzun, Sule Tas Gulen, Gulseren Pekbak, Deniz Kizilirmak, Yavuz Havlucu, Halil Donmez, Bahar Arslan, Gulden Pacaci Cetin, Sadan Soyyigit, Bilge Yilmaz Kara, Gulden Pasaoglu Karakis, Adile Berna Dursun, Resat Kendirlinan, Ayse Bilge Ozturk, Can Sevinc, Gokcen Omeroglu Simsek, Oznur Abadoglu, Pamir Cerci, Taskin Yucel, Irfan Yorulmaz, Zahide Ciler Tezcaner, Emel Cadalli Tatar, Ahmet Emre Suslu, Serdar Ozer, Engin Dursun, Arzu Yorgancioglu
INTRODUCTION: National data on asthma characteristics and the factors associated with uncontrolled asthma seem to be necessary for every country. For this purpose, we developed the Turkish Adult Asthma Registry for patients with asthma aiming to take a snapshot of our patients, thereby assigning the unmet needs and niche areas of intervention. METHODS: Case entries were performed between March 2018 and March 2022. A web-based application was used to record data...
April 25, 2023: Journal of Asthma
#38
JOURNAL ARTICLE
Kubilay Yıldırım, Musa Kavas, İlkay Sevgen Küçük, Zafer Seçgin, Çiğdem Gökcek Saraç
Beet Curly Top Iran Virus (BCTIV, Becurtovirus ) is a dominant and widespread pathogen responsible for great damage and yield reduction in sugar beet production in the Mediterranean and Middle East. CRISPR-based gene editing is a versatile tool that has been successfully used in plants to improve resistance against many viral pathogens. In this study, the efficiency of gRNA/Cas9 constructs targeting the expressed genes of BCTIV was assessed in sugar beet leaves by their transient expression. Almost all positive control sugar beets revealed systemic infection and severe disease symptoms (90%), with a great biomass reduction (68%) after BCTIV agroinoculation...
March 30, 2023: International Journal of Molecular Sciences
#39
JOURNAL ARTICLE
Xia Xu, Xuejiao Tian, Liankun Song, Jun Xie, Joseph C Liao, Joshua J Meeks, Xue-Ru Wu, Greg E Gin, Beverly Wang, Edward Uchio, Xiaolin Zi
Epidemiological evidence suggests that kava ( Piper methysticum Forst ) drinks may reduce the risk of cancer in South Pacific Island smokers. However, little is known about the anti-carcinogenic effects of kava on tobacco smoking-related bladder cancer and its underlying mechanisms. Here we show that dietary feeding of kawain (a major active component in kava root extracts) to mice either before or after hydroxy butyl(butyl) nitrosamine (OH-BBN) carcinogen exposure slows down urinary bladder carcinogenesis and prolongs the survival of the OH-BBN-exposed mice...
March 13, 2023: Biomolecules
#40
JOURNAL ARTICLE
Murat Kavas, Serdar Kaymaz, Selma Aydoğan Eroglu, Ugur Karasu, Veli Cobankara, Sibel Boga
OBJECTIVE AND AIM: Sarcoidosis, a multisystemic granulomatous disease, generally results in a lower quality of life (QoL) because of its unexpected course and diverse clinical symptoms. The Sarcoidosis Health Questionnaire (SHQ) evaluates the QoL for people with sarcoidosis in terms of their health. This study set out to validate the SHQ in a group of Turkish sarcoidosis patients. METHODS: The study included a total of 146 adult sarcoidosis patients (63 male and 83 female; mean age, 44±3...
March 28, 2023: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
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