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https://www.readbyqxmd.com/read/28337433/occupational-stress-and-burnout-among-surgeons-in-fiji
#1
Rajeev Patel, Peter Huggard, Annik van Toledo
AIM: This study examined the levels of occupational stress and burnout among surgeons in Fiji. METHODS: A document set comprising a cover letter; a consent form; a sociodemographic and supplementary information questionnaire; the Maslach Burnout Inventory (MBI); the 12-item General Health Questionnaire (GHQ-12); the Alcohol Use Disorders Identification Test (AUDIT); and the Professional Quality of Life (ProQOL) questionnaires were provided to surgeons from three public divisional hospitals in Fiji...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28335434/induction-of-g2m-arrest-by-flavokawain-a-a-kava-chalcone-increases-the-responsiveness-of-her2-overexpressing-breast-cancer-cells-to-herceptin
#2
Danielle D Jandial, Lauren S Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H Hoang, Xiaolin Zi
HER2/neu positive breast tumors predict a high mortality and comprise 25%-30% of breast cancer. We have shown that Flavokawain A (FKA) preferentially reduces the viabilities of HER2-overexpressing breast cancer cell lines (i.e., SKBR3 and MCF7/HER2) versus those with less HER2 expression (i.e., MCF7 and MDA-MB-468). FKA at cytotoxic concentrations to breast cancer cell lines also has a minimal effect on the growth of non-malignant breast epithelial MCF10A cells. FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities...
March 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28293192/indole-alkaloids-from-plants-as-potential-leads-for-antidepressant-drugs-a-mini-review
#3
Hazrulrizawati A Hamid, Aizi N M Ramli, Mashitah M Yusoff
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John's wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28214231/mechanisms-of-action-and-structure-activity-relationships-of-cytotoxic-flavokawain-derivatives
#4
Charlotte Thieury, Nicolas Lebouvier, Rémy Le Guével, Yann Barguil, Gaëtan Herbette, Cyril Antheaume, Edouard Hnawia, Yoshinori Asakawa, Mohammed Nour, Thierry Guillaudeux
22 Flavokawain derivatives (FKd) were obtained by one step syntheses in order to conduct a SAR study to understand the structural requirements for optimum and selective cytotoxicity. FKd and natural flavokawains A and B found into kava, a South Pacific traditional beverage, were evaluated against nine cancer and one healthy cell lines. The targeted cell cycle phases as well as the effects on the induction of apoptosis and cell cycle protein levels were investigated. Therapeutic improvements (more activity and selectivity) were achieved with FKd compared to natural flavokawains and notably with the 2',3,4',6'-tetramethoxychalcone (FKd 19)...
February 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28197023/genitourinary-sarcoidosis-an-essential-review-for-the-practicing-clinician
#5
REVIEW
Norman L Block, Bruce R Kava
INTRODUCTION: Sarcoidosis is a multisystem disease that commonly involves the lungs, but may also present with extrapulmonary manifestations. Genitourinary (GU) tract involvement has been traditionally thought to be rare, but that view may underestimate the true prevalence of the disease due to the often, silent presentation thereof. METHODS: The literature pertaining to sarcoidosis from the general systemic point of view, etiology and therapy and with regard to specific organs was reviewed by identifying key words in a PubMed search...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28160848/traditional-preparations-of-kava-piper-methysticum-inhibit-the-growth-of-human-colon-cancer-cells-in-vitro
#6
L S Einbond, A Negrin, D M Kulakowski, H-A Wu, V Antonetti, F Jalees, W Law, M Roller, S Redenti, E J Kennelly, M J Balick
BACKGROUND: Epidemiological studies indicate there is low incidence of colon cancer in the South Pacific islands, including Fiji, West Samoa, and Vanuatu. Cancer incidence has been shown to be inversely associated with kava (Piper methysticum G. Forst.) ingestion. Hypothesis/Purpose: Kava prepared traditionally will inhibit the growth of human cancer cells. This investigation entails preparation and analysis of kava extracts and study of the growth inhibitory activity of the extracts, alone and combined with hibiscus...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28144871/activity-of-the-endophytic-fungi-phlebia-sp-and-paecilomyces-formosus-in-decolourisation-and-the-reduction-of-reactive-dyes-cytotoxicity-in-fish-erythrocytes
#7
Lígia Maria Crubelati Bulla, Julio Cesar Polonio, Ana Luiza de Brito Portela-Castro, Vanessa Kava, João Lúcio Azevedo, João Alencar Pamphile
The current study investigates the potential for discolouration and degradation of Reactive Blue 19 and Reactive Black 5 textile dyes by endophytic fungi Phlebia sp. and Paecilomyces formosus as well as the potential cytotoxicity of products or by-products generated by the treatments in fish erythrocytes. It was observed at 30 days that both endophytes showed biodegradation activity with 0.1 g mL(-1) of dyes. P. formosus showed highest extracellular and intracellular protein content levels after the 15th day, and Phlebia sp...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28114364/eyelash-epilation-in-the-absence-of-trichiasis-results-of-a-population-based-prevalence-survey-in-the-western-division-of-fiji
#8
Colin Macleod, Chelsea Yalen, Robert Butcher, Umesh Mudaliar, Kinisimere Natutusau, Mere Rainima-Qaniuci, Chris Haffenden, Conall Watson, Naomi Cocks, Luisa Cikamatana, Chrissy H Roberts, Michael Marks, Eric Rafai, David C W Mabey, Mike Kama, Anthony W Solomon
BACKGROUND: The WHO definition of trachomatous trichiasis (TT) is "at least one eyelash touching the globe, or evidence of recent epilation of in-turned eyelashes", reflecting the fact that epilation is used as a self-management tool for TT. In Fiji's Western Division, a high TT prevalence (8.7% in those aged ≥15 years) was reported in a 2012 survey, yet a 2013 survey found no TT and Fijian ophthalmologists rarely see TT cases. Local anecdote suggests that eyelash epilation is a common behaviour, even in the absence of trichiasis...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28095587/quantitative-determination-of-lactones-in-piper-methysticum-kava-kava-by-supercritical-fluid-chromatography
#9
Adele Murauer, Markus Ganzera
A fast and validated supercritical fluid chromatography method for the quantitative determination of major lactones in Piper methysticum, a plant used against nervous anxiety, stress, and restlessness, was developed. The baseline separation of dihydrokavain, demethoxyyangonin, kavain, yangonin, dihydromethysticin, and methysticin was possible in less than 4 min on an Aquity UPC(2) BEH 1.7 µm column, in combination with a mobile phase comprising CO2 and methanol with diethylamine. The column temperature had a great impact on the results because only at 70 °C could kavain and yangonin be fully resolved...
January 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/28089573/what-is-a-difficult-transfer-analysis-of-7-714-embryo-transfers-the-impact-of-maneuvers-during-embryo-transfers-on-pregnancy-rate-and-a-proposal-of-objective-assessment
#10
Alejandro Kava-Braverman, Francisca Martínez, Ignacio Rodríguez, Manuel Álvarez, Pedro N Barri, Buenaventura Coroleu
OBJECTIVE: To establish the relationship between the degree of difficulty of ET and pregnancy rate (PR), with a view to proposing an algorithm for the objective assessment of ET. DESIGN: Retrospective, observational study. SETTING: In vitro fertilization unit. PATIENT(S): Women undergoing assisted reproductive technology (ART) with ET after IVF/intracytoplasmic sperm injection, in whom fresh embryo transfer or frozen-thawed embryo transfer was performed...
March 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28081487/comparative-genome-wide-phylogenetic-and-expression-analysis-of-sbp-genes-from-potato-solanum-tuberosum
#11
Musa Kavas, Aslıhan Kurt Kızıldoğan, Büşra Abanoz
Flowering time is a very important phase in transition to reproductive stage of life in higher plants. SQUAMOSA promoter-binding protein (SBP) gene family encodes plant-specific transcription factors that are involved in regulation of several developmental processes, especially flowering. Although SBP-box genes have been identified in different plants, there have been no study indicating the regulatory effect of SBP box in potato flowering. Here, we report for the first time the identification and characterization of SBP-box transcription factors as well as determination of expression level of SBP-box genes in Solanum tuberosum L...
January 4, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28079859/executive-functions-in-sarcoidosis-a-neurocognitive-assessment-study
#12
Özgür Bilgin Topçuoğlu, M Kavas, Hande Alibaş, Gülgün Çetintaş Afşar, Sibel Arınç, İpek Midi, Neşe Tuncer Elmacı
Not available.
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27936873/composition-of-endophytic-fungal-community-associated-with-leaves-of-maize-cultivated-in-south-brazilian-field
#13
Vivian J Szilagyi-Zecchin, Douglas Adamoski, Renata Rodrigues Gomes, Mariangela Hungria, Angela C Ikeda, Vanessa Kava-Cordeiro, Chirlei Glienke, Lygia V Galli-Terasawa
The objective of this study was to conduct a survey about fungi associated with leaves from two different maize plant lineages and to analyze their microbiota diversity. Isolated fungi were identified by morphological analysis and molecular taxonomy was performed using ITS1-5.8S-ITS2 rDNA. About 27 fungi morphotypes were obtained, 15 of them were from the first maize lineage. About 86.7% of the individuals belonged to the Dothideomycetes class (Phoma sorghina, Epicocum nigrum, Cladosporium sp., Bipolaris zeicola, and Alternaria alternata complex) and 13...
December 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/27935218/is-there-a-relationship-between-neonatal-sepsis-and-simple-minor-neurological-dysfunction
#14
Nazan Kavas, Ayşe Engin Arısoy, Asuman Bayhan, Bülent Kara, Ayla Günlemez, Gülcan Türker, Meral Oruç, Ayşe Sevim Gökalp
BACKGROUND: This study examined potential risk factors for and consequences of simple minor neurological dysfunction (SMND), in a group of very low birth weight newborns followed until preschool age. METHODS: This is a prospective longitudinal study. Children with a birth weight below 1,500 g were assessed at 4 to 6 years of age. Twenty eight children with a normal neurological examination and 35 children with simple minor neurological dysfunction were included in the final analysis...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27871602/hepatotoxicity-due-to-red-bush-tea-consumption-a-case-report
#15
Shamantha Reddy, Pragnyadipta Mishra, Sana Qureshi, Singh Nair, Tracey Straker
Many conventional drugs used today, including isoniazid, dapsone, and acetaminophen, are well recognized culprits of hepatotoxicity. With increasing use of complementary and alternative medical therapies, several herbal medicines, such as Ma-Huang, kava, and chaparral leaf, have been implicated as hepatotoxins. Hepatotoxicity may be the most frequent adverse reaction to these herbal remedies when taken in excessive quantities. A myriad of liver dysfunctions may occur including transient liver enzyme abnormalities due to acute and chronic hepatitis...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27728767/dihydromethysticin-dhm-blocks-tobacco-carcinogen-4-methylnitrosamino-1-3-pyridyl-1-butanone-nnk-induced-o-6-methylguanine-in-a-manner-independent-of-the-aryl-hydrocarbon-receptor-ahr-pathway-in-c57bl-6-female-mice
#16
Sreekanth C Narayanapillai, Shang-Hsuan Lin, Pablo Leitzman, Pramod Upadhyaya, Carolyn J Baglole, Chengguo Xing
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a key carcinogen responsible for tobacco smoke-induced lung carcinogenesis. Among the types of DNA damage caused by NNK and its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), O(6)-methylguanine (O(6)-mG) is likely the most carcinogen in A/J mice. Results of our previous studies showed that levels of O(6)-mG and other types of NNAL-derived DNA damage were preferentially reduced in the lung of female A/J mice upon dietary treatment with dihydromethysticin (DHM), a promising lung cancer chemopreventive agent from kava...
November 21, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27692836/predictive-models-and-risk-of-biopsy-progression-in-active-surveillance-patients
#17
Viacheslav Iremashvili, Murugesan Manoharan, Bruce R Kava, Dipen J Parekh, Sanoj Punnen
OBJECTIVE: To analyze the performance of different radical prostatectomy-based prognostic tools in predicting the biopsy progression in our active surveillance cohort. MATERIALS AND METHODS: We analyzed 326 patients with biopsy Gleason grade≤6,≤2 positive biopsy cores,≤20% tumor present in any core, prostate-specific antigen<15ng/dl, and clinical stages T1-T2a all of whom had at least single surveillance biopsy. Probabilities of pathologically relatively aggressive disease were estimated using Partin and Dinh risk tables and Kattan, Truong, and Kulkarni nomograms for each individual patient...
February 2017: Urologic Oncology
https://www.readbyqxmd.com/read/27664732/identification-of-genes-associated-with-asexual-reproduction-in-phyllosticta-citricarpa-mutants-obtained-through-agrobacterium-tumefaciens-transformation
#18
Eduardo Henrique Goulin, Daiani Cristina Savi, Desirrê Alexia Lourenço Petters, Vanessa Kava, Lygia Galli-Terasawa, Geraldo José Silva, Chirlei Glienke
Phyllosticta citricarpa is the epidemiological agent of Citrus Black Spot (CBS) disease, which is responsible for large economic losses worldwide. CBS is characterized by the presence of spores (pycnidiospores) in dark lesions of fruit, which are also responsible for short distance dispersal of the disease. The identification of genes involved in asexual reproduction of P. citricarpa can be an alternative for directional disease control. We analyzed a library of mutants obtained through Agrobacterium tumefaciens transformation system, looking for alterations in growth and reproductive structure formation...
November 2016: Microbiological Research
https://www.readbyqxmd.com/read/27617160/two-novel-gldc-mutations-in-a-neonate-with-nonketotic-hyperglycinemia
#19
Sarah L Nickerson, Shanti Balasubramaniam, Philippa A Dryland, Jennifer M Love, Maina P Kava, Donald R Love, Debra O Prosser
Nonketotic hyperglycinemia, also known as glycine encephalopathy (OMIM #605899), is an autosomal recessive disorder of glycine metabolism resulting from a defect in the glycine cleavage system. We report two novel mutations of the glycine decarboxylase (GLDC) gene observed in a compound heterozygous state in a neonate of mixed Maori and Caucasian parentage: c.395C>T p.(Ser132Leu) in exon 3, and c.256-?_334+?del p.(Ser86Valfs*119), resulting in an out-of-frame deletion of exon 2. Additionally, we describe our experience of implementing the ketogenic diet, alongside standard pharmacological therapy, and highlight its potential therapeutic benefit in severe nonketotic hyperglycinemia, particularly in seizure management...
September 2016: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/27587202/cisplatin-analogues-with-an-increased-interaction-with-dna-prospects-for-therapy
#20
Megan E Hardie, Hieronimus W Kava, Vincent Murray
Cisplatin is widely used as a cancer chemotherapeutic agent and this review covers the mechanism of action of cisplatin, cellular resistance to cisplatin, the genomic location of cisplatin adducts and the properties of DNA-targeted Pt complexes. A particular focus of this review is the interaction of Pt compounds with DNA. The technology involved in determining Pt-drug/DNA interactions has advanced and permits clearer views of this process. In particular, molecular biological techniques permit a more accurate and precise determination of the sequence specific preference of Pt adduct formation...
2016: Current Pharmaceutical Design
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