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https://www.readbyqxmd.com/read/29764806/temporal-efficacy-of-a-sulforaphane-based-broccoli-sprout-diet-in-prevention-of-breast-cancer-through-modulation-of-epigenetic-mechanisms
#1
Yuanyuan Li, Phillip Buckhaults, Shizhao Li, Trygve O Tollefsbol
Breast cancer is the most common cancer and the second leading cause of cancer death among women. An important risk factor for breast cancer is individual genetic background which is initially generated early in human life; for example, during the processes of embryogenesis and fetal development in utero. Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms...
May 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29753738/identification-and-expression-pattern-analysis-of-bomyb51-involved-in-indolic-glucosinolate-biosynthesis-from-broccoli-brassica-oleracea-var-italica
#2
Qingyue Yu, Guodong Hao, Jianxin Zhou, Jingying Wang, Ejiroghene Ruona Evivie, Jing Li
Glucosinolates are a class of amino acid-derived specialized metabolites characteristic of the Brassicales order. Trp derived indolic glucosinolates are essential for the effective plant defense responses to a wide range of pathogens and herbivores. In Arabidopsis, MYB51 is the key transcription factor positively regulates indolic glucosinolate production by activating certain biosynthetic genes. In this study, we report the isolation and identification of a MYB51 from broccoli designated as BoMYB51. Overexpression of BoMYB51 in Arabidopsis increased indolic glucosinolate production by upregulating biosynthetic genes and resulted in enhanced flagellin22 (Flg22) induced callose deposition...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29753270/estimating-acute-and-chronic-exposure-of-children-and-adults-to-chlorpyrifos-in-fruit-and-vegetables-based-on-the-new-lower-toxicology-data
#3
Patrycja Mojsak, Bożena Łozowicka, Piotr Kaczyński
This paper presents, for the first time, results for chlorpyrifos (CHLP) in Polish fruits and vegetables over the course of a long period of research, 2007-2016, with toxicological aspects. The challenge of this study was to re-evaluate the impact of chlorpyrifos residues in fruit and vegetables on health risk assessed via acute and chronic exposure based on old and new, lower, established values of: Average Daily Intakes (ADIs)/Acute Reference Doses (ARfDs) and Maximum Residue Levels (MRLs). A total of 3 530 samples were collected, and CHLP in the range of 0...
May 9, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29748497/profiling-of-phenolic-compounds-and-antioxidant-activity-of-12-cruciferous-vegetables
#4
Zhifeng Li, Hui Wen Lee, Xu Liang, Dong Liang, Qi Wang, Dejian Huang, Choon Nam Ong
The phenolic profiles of 12 cruciferous vegetables (pakchoi, choysum, Chinese cabbage, kailan, Brussels sprout, cabbage, cauliflower, broccoli, rocket salad, red cherry radish, daikon radish, and watercress) were studied with UHPLC-MS/MS. Antioxidant activity and total phenolic content (TPC) were also evaluated. A total of 74 phenolic compounds were identified, including 16 hydroxycinnamic acids and derivatives, and 58 flavonoids and derivatives. The main flavonoids identified were glycosylated quercetin, kaempferol and isorhamnetin, and the main hydroxycinnamic acids were ferulic, sinapic, caffeic and p -coumaric acids...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29741189/investigation-of-the-effects-of-mechanical-treatments-on-cellular-structure-integrity-and-vitamin-c-extractability-of-broccoli-brassica-oleracea-l-var-italica-by-lf-nmr
#5
Jinxin Yang, Xin Jin, Xiao Dong Chen
Extraction of nutrients from plants is an important unit operation in the food and biological industries. The target nutrient is usually spatially distributed throughout the plant tissue. The intact cell wall and adhering membranes are the main resistances to molecular diffusion. Therefore, disintegration of the intact structure, which in turn increases the permeability of adhering membranes, can significantly improve the nutrient extraction yield and efficiency. In this study, different physical treatments (homogenization, high pressure homogenization, and ball mill grinding) were applied to investigate their effects on the tissue microstructure and the release of vitamin C...
May 9, 2018: Food & Function
https://www.readbyqxmd.com/read/29738530/agronomic-performance-of-new-open-pollinated-experimental-lines-of-broccoli-brassica-oleracea-l-var-italica-evaluated-under-organic-farming
#6
Samira Sahamishirazi, Jens Moehring, Sabine Zikeli, Michael Fleck, Wilhelm Claupein, Simone Graeff-Hoenninger
In order to develop new open pollinating cultivars of broccoli for organic farming, two experiments were conducted during fall 2015 and spring 2016. This study was aimed at comparing the agronomic performance of eleven new open pollinating breeding lines of broccoli to introduce new lines and to test their seasonal suitability for organic farming. Field experiments were carried out at the organic research station Kleinhohenheim of the University of Hohenheim (Stuttgart-Germany). Different agronomic traits total biomass fresh weight, head fresh weight, head diameter, hollow-stem, fresh weight harvest index and marketable yield were assessed together with commercial control cultivars...
2018: PloS One
https://www.readbyqxmd.com/read/29730925/broccoli-sprout-extract-alleviates-alcohol-induced-oxidative-stress-and-endoplasmic-reticulum-stress-in-c57bl-6-mice
#7
Peng Lei, Wei Zhao, Bo Pang, Xiuli Yang, Bao-Long Li, Minghua Ren, Yu-Juan Shan
The potential efficacy of sulforaphane in protecting alcohol-induced hepatic injury in vivo and its underlying mechanism was investigated. Male C57BL/6 mice were orally administrated with broccoli sprout extract (BSE) containing sulforaphane (7.6, 25.2, 50.4 mg/kg.bw) once a day for 14 days. At the 13th day, mice were challenged with alcohol (5g/kg.bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44±1.24 nmol/mg prot, p<0.01) in liver. Our results showed that low, medium and high dose BSE markedly reversed the decrease of antioxidant capacity through enhancing glutathione (GSH) (2...
May 6, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29725066/isothermal-folding-of-a-light-up-bio-orthogonal-rna-origami-nanoribbon
#8
Emanuela Torelli, Jerzy Wieslaw Kozyra, Jing-Ying Gu, Ulrich Stimming, Luca Piantanida, Kislon Voïtchovsky, Natalio Krasnogor
RNA presents intringuing roles in many cellular processes and its versatility underpins many different applications in synthetic biology. Nonetheless, RNA origami as a method for nanofabrication is not yet fully explored and the majority of RNA nanostructures are based on natural pre-folded RNA. Here we describe a biologically inert and uniquely addressable RNA origami scaffold that self-assembles into a nanoribbon by seven staple strands. An algorithm is applied to generate a synthetic De Bruijn scaffold sequence that is characterized by the lack of biologically active sites and repetitions larger than a predetermined design parameter...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700576/targeted-overexpression-of-crh-receptor-subtype-1-in-central-amygdala-neurons-effect-on-alcohol-seeking-behavior
#9
L Broccoli, S Uhrig, G von Jonquieres, K Schönig, D Bartsch, N J Justice, R Spanagel, W H Sommer, M Klugmann, A C Hansson
RATIONALE: The corticotropin-releasing hormone (CRH) system is a key mediator of stress-induced responses in alcohol-seeking behavior. Recent research has identified the central nucleus of the amygdala (CeA), a brain region involved in the regulation of fear and stress-induced responses that is especially rich in CRH-positive neurons, as a key player in mediating excessive alcohol seeking. However, detailed characterization of the specific influences that local neuronal populations exert in mediating alcohol responses is hampered by current limitations in pharmacological and immunohistochemical tools for targeting CRH receptor subtype 1 (CRHR1)...
April 26, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29693632/fruit-and-vegetable-by-products-to-fortify-spreadable-cheese
#10
Annalisa Lucera, Cristina Costa, Valeria Marinelli, Maria Antonietta Saccotelli, Matteo Alessandro Del Nobile, Amalia Conte
In this work, spreadable cheese was enriched with flours from by-products (red and white grape pomace, tomato peel, broccoli, corn bran, and artichokes) as sources of fibres and antioxidant compounds. The physicochemical and the sensory properties of all the cheese samples were analysed. Results revealed that total phenolic content, flavonoids, and antioxidant activity of samples containing grape pomace significantly increased, followed by broccoli, artichoke, corn bran, and tomato peel by-products, compared to the control cheese...
April 25, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29691233/evaluation-of-biodistribution-of-sulforaphane-after-administration-of-oral-broccoli-sprout-extract-in-melanoma-patients-with-multiple-atypical-nevi
#11
Shawn Tahata, Shivendra V Singh, Yan Lin, Eun-Ryeong Hahm, Jan H Beumer, Susan M Christner, Uma N Rao, Cindy Sander, Ahmad A Tarhini, Hussein Tawbi, Laura K Ferris, Melissa Wilson, Amy Rose, Catherine M Dietz, Ellen K Hughes, Jed W Fahey, Sancy A Leachman, Pamela B Cassidy, Lisa H Butterfield, Hassane M Zarour, John M Kirkwood
Broccoli sprout extract containing sulforaphane (BSE-SFN) has been shown to inhibit ultraviolet radiation-induced damage and tumor progression in skin. This study evaluated the toxicity and potential effects of oral BSE-SFN at three dosages. Seventeen patients who each had at least 2 atypical nevi and a prior history of melanoma were randomly allocated to 50, 100, or 200 µmol oral BSE-SFN daily for 28 days. Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28...
April 24, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29688618/se-methylselenocysteine-ameliorates-neuropathology-and-cognitive-deficits-by-attenuating-oxidative-stress-and-metal-dyshomeostasis-in-alzheimer-model-mice
#12
Yongli Xie, Qiong Liu, Lin Zheng, BingTao Wang, Xiaogang Qu, Jiazuan Ni, Yan Zhang, Xiubo Du
SCOPE: Se-methylselenocysteine (SMC) is a major selenocompound in selenium (Se) enriched plants such as garlic and broccoli florets. Se is vital for proper brain function, and Se-deficient is considered to be related with cognitive impairment and Alzheimer's disease (AD). In this study, we evaluated for the first time the potential of SMC in intervening cognitive deficits and neuropathology of triple transgenic AD (3 × Tg-AD) mice. METHODS AND RESULTS: AD mice were treated with SMC (0...
April 24, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29681684/the-evidence-of-proteases-in-sprouted-seeds-and-their-application-for-animal-protein-digestion
#13
Rafał I Rawski, Przemysław T Sanecki, Małgorzata Dżugan, Klaudia Kijowska
It has been experimentally proven that germinated plant seeds, such as leek, red clover, broccoli, and others contain proteases, which are able to digest animal protein such as gelatin, bovine albumin, casein, and egg albumin. Preliminary tests were carried out with the use of a semi-qualitative gelatin test, which is often applied to prove the presence of fruit enzymes. Quantitative examinations were carried out with the use of a ninhydrin reaction for amino acid determination as well as the Bradford and Smith methods for protein determination...
2018: Chemické Zvesti
https://www.readbyqxmd.com/read/29678981/cohort-profile-the-italian-network-of-longitudinal-metropolitan-studies-in-limes-a-multicentre-cohort-for-socioeconomic-inequalities-in-health-monitoring
#14
Nicola Caranci, Chiara Di Girolamo, Paolo Giorgi Rossi, Teresa Spadea, Barbara Pacelli, Serena Broccoli, Paola Ballotari, Giuseppe Costa, Nicolás Zengarini, Nera Agabiti, Anna Maria Bargagli, Laura Cacciani, Cristina Canova, Laura Cestari, Annibale Biggeri, Laura Grisotto, Gianna Terni, Gianfranco Costanzo, Concetta Mirisola, Alessio Petrelli
PURPOSE: The Italian Network of Longitudinal Metropolitan Studies (IN-LiMeS) is a system of integrated data on health outcomes, demographic and socioeconomic information, and represents a powerful tool to study health inequalities. PARTICIPANTS: IN-LiMeS is a multicentre and multipurpose pool of metropolitan population cohorts enrolled in nine Italian cities: Turin, Venice, Reggio Emilia, Modena, Bologna, Florence, Leghorn, Prato and Rome. Data come from record linkage of municipal population registries, the 2001 population census, mortality registers and hospital discharge archives...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29675806/comparative-study-of-predominant-phytochemical-compounds-and-proapoptotic-potential-of-broccoli-sprouts-and-florets
#15
Paweł Paśko, Małgorzata Tyszka-Czochara, Agnieszka Galanty, Joanna Gdula-Argasińska, Paweł Żmudzki, Henryk Bartoń, Paweł Zagrodzki, Shela Gorinstein
The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets...
April 19, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29674440/lenalidomide-in-pretreated-mantle-cell-lymphoma-patients-an-italian-observational-multicenter-retrospective-study-in-daily-clinical-practice-the-lenamant-study
#16
Vittorio Stefoni, Cinzia Pellegrini, Alessandro Broccoli, Luca Baldini, Monica Tani, Emanuele Cencini, Amalia Figuera, Michela Ansuinelli, Elisa Bernocco, Maria Cantonetti, Maria Christina Cox, Filippo Ballerini, Chiara Rusconi, Carlo Visco, Luca Arcaini, Angelo Fama, Roberto Marasca, Stefano Volpetti, Alessia Castellino, Catello Califano, Marina Cavaliere, Guido Gini, Anna Marina Liberati, Gerardo Musuraca, Anna Lucania, Giuseppina Ricciuti, Lisa Argnani, Pier Luigi Zinzani
BACKGROUND: Mantle cell lymphoma (MCL) has the worst prognosis of B-cell subtypes owing to its aggressive clinical disease course and incurability with standard chemo-immunotherapy. Options for relapsed MCL are limited, although several single agents have been studied. Lenalidomide is available in Italy for patients with MCL based on a local disposition of the Italian Drug Agency. SUBJECTS, MATERIALS, AND METHODS: An observational retrospective study was conducted in 24 Italian hematology centers with the aim to improve information on effectiveness and safety of lenalidomide use in real practice...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29666533/purple-head-broccoli-brassica-oleracea-l-var-italica-plenck-a-functional-food-crop-for-antioxidant-and-anticancer-potential
#17
Ashun Chaudhary, Sonika Choudhary, Upendra Sharma, Adarsh Pal Vig, Bikram Singh, Saroj Arora
Natural foods are used in many folks and household treatments and have immense potential to treat a serious complication and health benefits, in addition to the basic nutritional values. These food products improve health, delay the aging process, increase life expectancy, and possibly prevent chronic diseases. Purple head Brassica oleracea L. var. italica Plenck is one of such foods and in current studies was explored for chemical compounds at different development stages by gas chromatography-mass spectrometry...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29659310/effect-of-feeding-broccoli-floret-residues-on-leghorn-layer-performance-and-egg-quality-and-nutrient-digestibility
#18
A F Mustafa, B Baurhoo
1. A study was conducted to determine the effects of dried broccoli floret (DBF) on egg production parameters, egg quality, and apparent nutrient digestibility of laying hens. It was hypothesised that feeding DBF can improve egg quality without adversely affecting layer performance. 2. Seventy-two White Leghorn layers aged 62 weeks were randomly allotted to four dietary treatments (six cage replicates with three hens each) and fed diets containing 0, 40, 80, and 120 g/kg DBF in feed for 56 d. 3. Inclusion of DBF had no effect on feed intake, egg production, feed conversion ratio or egg components...
April 16, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29652847/comparative-phytonutrient-analysis-of-broccoli-by-products-the-potentials-for-broccoli-by-product-utilization
#19
Mengpei Liu, Lihua Zhang, Suk Lan Ser, Jonathan R Cumming, Kang-Mo Ku
The phytonutrient concentrations of broccoli ( Brassica oleracea var. italica) florets, stems, and leaves were compared to evaluate the value of stem and leaf by-products as a source of valuable nutrients. Primary metabolites, including amino acids, organic acids, and sugars, as well as glucosinolates, carotenoids, chlorophylls, vitamins E and K, essential mineral elements, total phenolic content, antioxidant activity, and expression of glucosinolate biosynthesis and hydrolysis genes were quantified from the different broccoli tissues...
April 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29627770/essential-medicines-for-emergency-care-in-africa
#20
Morgan C Broccoli, Jennifer L Pigoga, Mulinda Nyirenda, Lee Wallis, Emilie J Calvello Hynes
OBJECTIVES: Essential medicines lists (EMLs) are efficient means to ensure access to safe and effective medications. The WHO has led this initiative, generating a biannual EML since 1977. Nearly all countries have implemented national EMLs based on the WHO EML. Although EMLs have given careful consideration to many public health priorities, they have yet to comprehensively address the importance of medicines for treating acute illness and injury. METHODS: We undertook a multistep consensus process to establish an EML for emergency care in Africa...
April 7, 2018: Emergency Medicine Journal: EMJ
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