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https://www.readbyqxmd.com/read/27929606/effect-of-a-corticosteroid-triamcinolone-and-chlorhexidine-on-chemotherapy-induced-oxidative-stress-in-the-buccal-mucosa-of-rats
#1
Sami Gümüş, Murat Yarıktaş, Mustafa Nazıroğlu, Abdülhadi Cihangir Uğuz, Giray Aynali, Şirin Başpınar
Oral mucositis manifests as erythematous and ulcerative lesions of the oral mucosa. Among its various causes, cancer treatment (e.g., chemotherapy with or without radiation therapy) is one of the more well known. It has been widely mentioned that oxidative stress parameters such as lipid peroxidation levels increase during the cancer process. Glutathione is one of the major intracellular enzymes used to detoxify oxidant molecules; it exists in both a reduced and oxidized state. Reduced glutathione is used as a substrate to synthesize glutathione peroxidase...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27927880/serum-osteoprotegrin-opg-in-subclinical-atherosclerosis-in-systemic-lupus-erythematosus
#2
A N Kiani, P Aukrust, T Ueland, I Hollan, E Barr, L S Magder, M Petri
INTRODUCTION: Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is strongly related to vascular calcification. We determined the association of this biomarker with subclinical atherosclerosis in systemic lupus erythematous (SLE). METHODS: We measured OPG and markers of subclinical atherosclerosis (coronary artery calcium (CAC), carotid intima-media thickness (cIMT) carotid plaque) in 166 SLE patients (91% female, 64% Caucasian, 31% African American, 5% others, mean age 45 years)...
December 6, 2016: Lupus
https://www.readbyqxmd.com/read/27922587/tinea-incognito-due-to-trichophyton-mentagrophytes-case-report
#3
Camila Quiñones, Paula Hasbún, Walter Gubelin
Tineas are frequent infections caused by dermatophytes that are able to invade keratinized tissue, causing rounded, erythematous, scaly lesions. Nonetheless, in tinea incognito the lesions are modified because of inappropriate use of topical corticosteroids or calcineurin inhibitors, making it difficult to diagnose. We present a case of a 12-year-old male child that presents with erythematous lesions on the right eyebrow, which at first was diagnosed as a contact dermatitis, so corticosteroids were indicated...
November 9, 2016: Medwave
https://www.readbyqxmd.com/read/27922246/neonatal-lupus-erythematosus-report-of-a-case-with-cutaneous-hematological-and-hepatobiliary-findings
#4
Andaç Salman, Merve Hatun Sarıçam, Ayşe Deniz Yücelten, Cuyan Demirkesen, Tülin Ergun
Neonatal lupus erythematosus is an autoimmune disorder mainly affecting the heart and skin. It is the most common cause of congenital heart block. In addition, hematological, hepatobiliary and neurological involvement may occur. Herein, we report a 23-day-old infant presented with annular, erythematous, and scaly and atrophic lesions on the face and trunk. Based on the clinical, laboratory and histopathological findings, she was diagnosed as neonatal lupus erythematosus. Neonatal lupus eryhtematosus should be considered in infants presenting with annular skin lesions, and we present this case to highlight the value of high index of clinical suspicion in diagnosis...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27915962/generalized-pustular-psoriasis-von-zumbusch-type-following-renal-transplant-a-case-report
#5
Georgia Dedemadi, Maria Koukoulaki, Vassileios Vougas, Constantinos Noutsis, Aikaterini Pantelidaki, Spiros Drakopoulos
Generalized pustular psoriasis appears as an uncommon variant form of psoriasis consisting of widespread pustules on an erythematous background (von Zumbusch). A 39-year-old male patient with a history of plaque psoriasis since the age of 9 who had an acute relapse of generalized pustular psoriasis 12 days following a successful renal transplantation is presented. Despite administered immunosuppression for transplantation, the addition of cyclosporine and methotrexate did not reverse the ongoing process of disease and the patient died on the 57th posttransplant day due to multiorgan failure subsequent to severe bone marrow suppression...
December 2, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27915438/variations-in-clinical-presentation-and-anatomical-distribution-of-gross-lesions-of-african-swine-fever-in-domestic-pigs-in-the-southern-highlands-of-tanzania-a-field-experience
#6
Maulilio John Kipanyula, Solomon Wilson Nong'ona
African swine fever is a contagious viral disease responsible for up to 100% mortality among domestic pigs. A longitudinal study was carried out to determine the clinical presentation and anatomical distribution of gross lesions in affected pigs in Mbeya region, Tanzania during the 2010 to 2014 outbreaks. Data were collected during clinical and postmortem examination by field veterinarians and using a structured questionnaire. A total of 118 respondents (100%) showed awareness about African swine fever. During previous outbreaks, the mortality rate was almost 100%, while in 2014 it was estimated to be less than 50%...
December 3, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27914677/erythematous-infiltrated-plaques-as-an-onset-manifestation-of-rapidly-evolving-lymphoma
#7
María Dorado Fernández, Javier Ruiz Martínez, Francisco Pastor Quirante, Jesús Hernández-Gil Sánchez
No abstract text is available yet for this article.
November 30, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27913079/rash-decisions-an-approach-to-dangerous-rashes-based-on-morphology
#8
Jamie Santistevan, Brit Long, Alex Koyfman
BACKGROUND: Rash is a common complaint in the emergency department. Many causes of rash are benign; however, some patients may have a life-threatening diagnosis. OBJECTIVE: This review will present an algorithmic approach to rashes, focusing on life-threatening causes of rash in each category. DISCUSSION: Rash is common, with a wide range of etiologies. The differential is broad, consisting of many conditions that are self-resolving. However, several conditions associated with rash are life threatening...
November 29, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27904279/eccrine-syringofibroadenoma-in-a-patient-with-long-standing-exfoliative-dermatitis
#9
Eun Jung Ko, Kui Young Park, Hyun Jung Kwon, Joo Hyun Shim, Seong Jun Seo
Eccrine syringofibroadenoma (ESFA) is a rare benign cutaneous adnexal lesion characterized by a hyperplastic epithelium and eccrine ductal differentiation. In the present case, a 73-year-old Korean male presented with symmetrical numerous widespread, pinkish nodules with a cobblestone appearance over both legs for 2 years. He had a history of generalized erythematous scaly patches over his entire body for 20 years. On histopathologic findings, diagnosis of ESFA was confirmed. Our unusual and interesting case emphasizes the first report described one case in which multiple cobblestone like ESFAs arising from long-standing exfoliative dermatitis...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904278/tick-bite-by-nymphal-amblyomma-testudinarium
#10
Yeong Ho Kim, Ji Hyun Lee, Young Min Park, Jun Young Lee
Ticks are parasites that usually suck the blood of wild or domestic animals; rarely, they ingest human blood and spread various febrile infectious diseases along with skin problems. Out of 40 cases of tick bite reported in Korea, only 3 were caused by nymphal ticks, and tick bites by nymphal Amblyomma testudinarium have not been reported previously. Herein, we report a rare case of tick bite by nymphal A. testudinarium. A 57-year-old woman presented with an asymptomatic solitary erythematous nodule on the left thigh that had been present for 6 days...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904277/herpes-zoster-duplex-unilateralis-two-cases-and-brief-literature-review
#11
Jee Hee Son, Bo Young Chung, Hye One Kim, Hee Jin Cho, Chun Wook Park
Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904193/solitary-erythematous-plaque-on-the-nasolabial-fold
#12
Anupam Das, Saumya Panda
No abstract text is available yet for this article.
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27902603/purulent-lupus-panniculitis-unmasked-by-fdg-pet-ct-scan-a-case-report
#13
Kornelis S M van der Geest, Rada V Moerman, Klaas P Koopmans, Nicole D Holman, Wilbert M T Janssen
RATIONALE: Lupus panniculitis (LP) is a unique variant of cutaneous lupus erythematosus. Clinical manifestations are typically mild and include erythema, nodules, and small ulcers. In certain cases, diagnosing LP may be challenging. Skin overlying the typical subcutaneous inflammation may appear normal, and bacterial superinfections of the skin sometimes mask the underlying LP. It has been suggested that a computed tomography (CT) scan may help to identify obscure LP lesions. Here, we report a case of a 54-year-old woman with an unusually severe form of LP, in which the full disease extent was only revealed by a fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27900974/disseminated-mycobacteria-chelonae-infection-in-a-kidney-pancreas-transplant-recipient-a-case-report-and-review-of-the-literature
#14
Shafi Malik, Ananda Ghosh, Shahid Husain
A 40-year-old male with a long-standing history of type 1 diabetes with end-stage renal failure underwent combined kidney-pancreas (KP) transplant from a standard criteria donor. Post-operative course was uncomplicated with good primary function of both transplant grafts. Induction was with thymoglobulin and maintenance immunosuppression was with tacrolimus, mycophenolate mofetil and prednisolone. Nine weeks post-transplant, the patient developed dysfunction of both grafts. Panel reactive antibody testing revealed that the patient had developed a de novo donor-specific antibody and considering an antibody-mediated rejection the patient was treated with intravenous pulse methyl prednisone 500 mg ×3 doses, IV immunoglobulin 2 mg/kg in two divided doses, and ATG 7 mg/kg (total dose of 700 mg)...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27896191/comparison-of-the-effectiveness-of-ablative-and-non-ablative-fractional-laser-treatments-for-early-stage-thyroidectomy-scars
#15
Jin-Uk Jang, Soo-Young Kim, Eul-Sik Yoon, Woo-Kyung Kim, Seung-Ha Park, Byung-Il Lee, Deok-Woo Kim
BACKGROUND: Open thyroidectomy is conventionally performed at the anterior side of neck, which is a body part with a comparatively great degree of open exposure; due to this, postoperative scarring may cause distress in patients. We aimed to compare the effects of ablative and nonablative fractional laser treatments on thyroidectomy scars. We examined medical records in a retrospective manner and analyzed scars based on their digital images by using the modified Manchester Scar Scale (mMSS)...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27891740/minocycline-successfully-treats-exaggerated-granulomatous-hypersensitivity-reaction-to-mw-immunotherapy
#16
Keshavamurthy Vinay, Tarun Narang, Uma N Saikia, Muthu Sendhil Kumaran, Sunil Dogra
Mycobacterium W (Mw) vaccine has been found to be effective in the treatment of leprosy and warts. Despite increasing use of Mw immunotherapy, data on its safety is limited. We report a series of eight patients who developed persisting injection site granulomatous reaction following Mw immunotherapy and were successfully treated with minocycline. Eight patients with persistent nodular swelling at the site of Mw injections were identified. Seven of them had received Mw immunotherapy for cutaneous warts and one for verrucous epidermal nevus...
November 28, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27891734/impending-skin-necrosis-after-dermal-filler-injection-a-golden-time-for-first-aid-intervention
#17
Ji Yeon Hong, Joon Seok, Ga Ram Ahn, Yu-Jin Jang, Kapsok Li, Beom Joon Kim
Vascular compromise with impending skin necrosis is one of the most serious potential complications. Early recognition of vascular occlusion and swift and aggressive treatment are required to avoid any irreversible changes. However, initial symptoms of a vascular event are often dismissed as simple post-procedural discomfort. If more than 3 days pass after filler injection, crust formation is initiated over the erythematous base along with a rim of fibrous tissue. Due to the replacement of normal tissues by fibrous material, the healing process may result in scar formation in spite of debridement and aggressive dressing changes...
November 28, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27891439/o-brien-s-granuloma-a-case-report
#18
Pratik Mukesh Thacker, Kashinath Nayak, Flora Dorothy Lobo, Pavithra Govindasamy
Actinic granuloma is a self-limiting chronic disorder with elastolytic granulomas, mainly of the sun exposed skin and unknown pathogenesis. We report a case of a middle aged woman with multiple annular erythematous lesions. Histopathology revealed degenerated elastic fibres with histiocyte aggregates surrounded by multiple giant cells suggestive of elastolytic granulomas. She also had associated dyslipidemia and hypothyroidism. Actinic granuloma is relatively rare in the Indian population and needs to be differentiated from conditions like sarcoidosis and granuloma annulare...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891378/isoniazid-induced-lupus-presenting-as-oral-mucosal-ulcers-with-pancytopenia
#19
Ria Shah, Padmaraj Ankale, Kanishk Sinha, Aparna Iyer, T K Jayalakshmi
Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890958/nonhealing-genital-ulcer-in-aids-a-diagnostic-dilemma
#20
Yogesh S Marfatia, Devi Sathianadha Menon, Sheethal Jose, Brijesh Kumar Patel
HIV/AIDS-related immune alteration poses many diagnostic and therapeutic challenges. HIV-positive 44-year-old male, on second-line antiretroviral therapy (ART) presented with asymptomatic non healing, well-defined, erythematous ulcer over penis since 8 months with serosanguinous discharge. Inguinal lymph nodes were not palpable. Tzanck smear was negative. Biopsy was not done as the patient was not willing for the same. Acyclovir was given considering herpes infection to which there was no response, and hence azithromycin and metronidazole were given, without improvement...
July 2016: Indian Journal of Sexually Transmitted Diseases
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