keyword
https://read.qxmd.com/read/38462959/significance-of-clinical-immunological-patterns-and-diagnostic-yield-of-biopsies-in-microscopic-polyangiitis-and-granulomatosis-with-polyangiitis
#21
JOURNAL ARTICLE
João Fernandes-Serodio, Sergio Prieto-González, Georgina Espígol-Frigolé, Roberto Ríos-Garcés, Verónica Gómez-Caverzaschi, Olga Araújo, Gerard Espinosa, Raül Jordà-Sánchez, Marco A Alba, Luis Quintana, Miquel Blasco, Elena Guillen, Odette Viñas, Estíbaliz Ruiz-Ortiz, Laura Pelegrín, Maite Sainz de la Maza, Bernardo Sánchez-Dalmau, Adriana García-Herrera, Manel Solé, Paola Castillo, Iban Aldecoa, María D Cano, Jacobo Sellarés, Fernanda Hernández-González, Carlos Agustí, Carmen M Lucena, Antonio López-Rueda, Marcelo Sánchez, Mariana Benegas, Sebastián Capurro, Raimon Sanmartí, Josep M Grau, Isabel Vilaseca, Isam Alobid, Maria C Cid, José Hernández-Rodríguez
BACKGROUND: Microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) are the two major antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). OBJECTIVES: To characterize a homogenous AAV cohort and to assess the impact of clinicopathological profiles and ANCA serotypes on clinical presentation and prognosis. Clinical differences in GPA patients according to ANCA serotype and the diagnostic yield for vasculitis of biopsies in different territories were also investigated...
March 11, 2024: Journal of Internal Medicine
https://read.qxmd.com/read/38461090/-bronchial-involvement-in-granulomatosis-with-polyangiitis
#22
JOURNAL ARTICLE
R Batton, P Le Guen, A Cazes, M-P Debray, C Taillé
No abstract text is available yet for this article.
March 8, 2024: Revue des Maladies Respiratoires
https://read.qxmd.com/read/38457125/biologic-therapy-in-rare-eosinophil-associated-disorders-remaining-questions-and-translational-research-opportunities
#23
JOURNAL ARTICLE
Paneez Khoury, Florence Roufosse, Fei Li Kuang, Steven J Ackerman, Praveen Akuthota, Bruce S Bochner, Mats W Johansson, Sameer K Mathur, Princess U Ogbogu, Lisa A Spencer, Michael E Wechsler, Nives Zimmermann, Amy D Klion
Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood and/or tissue hypereosinophilia and eosinophil-related clinical manifestations. Although the recent availability of biologic therapies that directly and indirectly target eosinophils has the potential to dramatically improve treatment options for all EADs, clinical trials addressing their safety and efficacy in rare EADs have been relatively few...
March 8, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38448175/-anca-negative-granulomatosis-with-polyangiitis-a-case-report
#24
JOURNAL ARTICLE
C H Sun, M Li, Q Y Li, Y Liang, Y C Sun, X Zhu
We reported a case of 73-year-old male with multiple pulmonary nodules and cavities. The patient was admitted with a chief complaint of "dry cough with shortness of breath for 3 months". Chest CT showed multiple irregular masses, nodules, and patchy lesions in both lungs, accompanied by the formation of cavities. He also had anemia and renal dysfunction. Despite given empirical anti-infective and anti-tuberculosis treatments, the pulmonary nodules progressed, and the cavities enlarged. Anti-neutrophil cytoplasmic antibodies (ANCA) were negative twice...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38446491/granulomatosis-with-polyangiitis-presenting-with-intestinal-perforation
#25
JOURNAL ARTICLE
Hirotaka Yamamoto, Yoshinori Taniguchi
No abstract text is available yet for this article.
March 5, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38446461/eosinophilic-granulomatosis-with-polyangiitis-associated-subarachnoid-hemorrhage
#26
JOURNAL ARTICLE
Hirotaka Yamamoto, Yoshinori Taniguchi
No abstract text is available yet for this article.
March 5, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38445642/treatment-strategies-for-anca-associated-vasculitides-from-standard-protocols-to-future-horizons
#27
REVIEW
Francesco Reggiani, Matteo Stella, Marta Calatroni, Renato Alberto Sinico
INTRODUCTION: ANCA-associated vasculitides (AAV), classified into granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis represent a group of disorders characterized by necrotizing vasculitis of small vessels, endothelial injury and tissue damage. The outcomes and prognosis of AAV have undergone significant changes with the introduction of glucocorticoids (GCs) and other immunosuppressants (cyclophosphamide, azathioprine, methotrexate, and mycophenolate mofetil)...
March 6, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38445136/hypertrophic-pachymeningitis-an-unusual-cause-of-headache
#28
Joud Enabi, Muhammad Waqar Sharif, Raksha Venkatesan, Hema Kondakindi, Maida Faheem
Hypertrophic pachymeningitis (HP) is a rare condition characterized by inflammation and thickening of the dura mater. It can be idiopathic or secondary to various causes, including infections, tumors, or systemic inflammatory diseases. Diagnosis is challenging due to its rarity and the overlap of symptoms with other conditions. We present the case of a 42-year-old Hispanic woman with diabetes mellitus type 2 and end-stage kidney disease who presented with chest pain, dry cough, mild dyspnea, and chronic occipital headaches...
February 2024: Curēus
https://read.qxmd.com/read/38431768/granulomatosis-with-polyangiitis-presented-as-multiple-cutaneous-abscesses-after-hysterectomy
#29
JOURNAL ARTICLE
Xiaoting Song, Mengrui Li, Yinggai Song, Ping Tu, Hang Li, Yang Wang, Rong Xu, Min Chen, Xiaojuan Yu, Suxia Wang, Fude Zhou, Minghui Zhao, Ruoyu Li, Xiaoyu Jia, Xiaowen Wang
No abstract text is available yet for this article.
March 3, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38428978/prospective-study-of-complications-and-sequelae-of-glucocorticoid-therapy-in-anca-associated-vasculitis
#30
JOURNAL ARTICLE
Paul J Scherbacher, Bernhard Hellmich, You-Shan Feng, Christian Löffler
OBJECTIVE: Glucocorticoids (GC) are a cornerstone in treating antineutrophil cytoplasmic antibodies-associated vasculitides (AAV), however, they add to morbidity and mortality. To date, GC toxicity in AAV has rarely been systematically investigated. METHODS: Patients with a confirmed AAV were included in this monocentric prospective study. GC toxicity was assessed by structured interviews, clinical examination and electronic medical record analysis. The Glucocorticoid Toxicity Index (GTI) consisting of the Aggregate Improvement Score (GTI-AIS) and the Cumulative Worsening Score (GTI-CWS) was assessed at two time points (t1 baseline, t2 6 months later)...
February 29, 2024: RMD Open
https://read.qxmd.com/read/38428961/pneumocephalus-and-cerebral-abscess-in-granulomatosis-with-polyangiitis
#31
JOURNAL ARTICLE
Yasutaka Okita, Masashi Okamoto, Jun Fujimoto, Atsushi Kumanogoh
Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease that causes necrotizing vasculitis of small- to medium-sized blood vessels and necrotizing granulomatous inflammation, primarily of the upper and lower respiratory system. A 33-year-old woman presented with a 16-month history of headaches, nasal obstruction, and anosmia.
March 1, 2024: Journal of Rheumatology
https://read.qxmd.com/read/38414678/a-rare-presentation-of-wegener-s-granulomatosis-with-perinuclear-antineutrophil-cytoplasmic-antibody-positivity
#32
Dhammika P Rathnayake, Kvc Janaka, Hassan Hussain, Sudeshan Senanayake, Wds Lakindi
Wegener's granulomatosis (WG), also termed granulomatosis with polyangiitis, is a vasculitic condition with numerous systemic manifestations. It is mainly a pauci-immune vasculitis which involves small and medium-sized vessels. Herein, we report a case of a 72-year-old female with a background history of type 2 diabetes mellitus and hypertension. She presented to the hospital with recurrent nasal congestion, headache, and intermittent facial pain for two months' duration. At the initial presentation, she was diagnosed with pansinusitis, for which she was treated with antibiotics and was discharged...
January 2024: Curēus
https://read.qxmd.com/read/38411043/stroke-heralding-granulomatosis-with-polyangiitis
#33
JOURNAL ARTICLE
Piotr Janowiak, Agnieszka Gorzewska, Jolanta Szade, Magdalena Bednarska, Jacek Jassem, Ewa Jassem
No abstract text is available yet for this article.
February 23, 2024: Polish Archives of Internal Medicine
https://read.qxmd.com/read/38407965/suspected-retinal-toxicity-after-multiple-intravitreal-ganciclovir-injections-in-a-patient-of-cmv-retinitis
#34
JOURNAL ARTICLE
Rohan Kapoor, SriniVas Sadda, Mudit Tyagi
PURPOSE: Intravitreal Ganciclovir has been one of the treatments of choice for cytomegalovirus (CMV) retinitis and has been used extensively for its treatment since 1987. It has not been shown to have any major adverse effects. There are no reports on any retinal toxicity even after multiple, repeated injections. Herein, we report a rare case of retinal toxicity after multiple intravitreal injections in a patient of CMV retinitis. CASE REPORT: A 69-year-old one eyed male, who was on oral corticosteroids and systemic immunosuppression for Granulomatosis with Polyangiitis, presented with CMV retinitis in both eyes...
February 26, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38404157/the-impact-of-coronavirus-19-vaccination-on-anti-nuclear-cytoplasmic-antibody-vasculitis-hospitalisations-in-a-sydney-health-network
#35
JOURNAL ARTICLE
Dane Turner, Grant Luxton, Kenneth Yong, Anthony Sammel
There have been reports of COVID-19 vaccination triggering anti-nuclear cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but no robust studies have examined the link. This retrospective cohort study assessed the impact of COVID vaccination on the rate of denovo and relapsed AAV in a Sydney Local Health District from 2018 to 2022. Despite more than 95% of the population receiving vaccination, the case rate of AAV was stable. These findings do not support a relationship between COVID vaccination and AAV...
February 25, 2024: Internal Medicine Journal
https://read.qxmd.com/read/38403698/-advances-in-diagnosis-and-treatment-in-eosinophilic-granulomatosis-with-polyangiitis-egpa
#36
JOURNAL ARTICLE
Masami Taniguchi, Yosuke Kamide, Yuto Nakamura, Kentaro Watai, Yuma Fukutomi, Kiyoshi Sekiya
No abstract text is available yet for this article.
2024: Arerugī, [Allergy]
https://read.qxmd.com/read/38403565/granulomatosis-with-polyangiitis-as-a-trigger-for-acute-myeloid-leukemia
#37
Ignacio Boira Enrique, Violeta Esteban Ronda, Eusebi Chiner Vives
No abstract text is available yet for this article.
February 7, 2024: Archivos de Bronconeumología
https://read.qxmd.com/read/38399554/audiological-manifestations-in-patients-with-granulomatosis-with-polyangiitis
#38
JOURNAL ARTICLE
Vija Vainutienė, Justinas Ivaška, Jolanta Dadonienė, Vilma Beleškienė, Tatjana Ivaškienė, Eugenijus Lesinskas
Background and Objectives : Granulomatosis with Polyangiitis (GPA) is a rare, autoimmune, multisystemic disease characterized by vasculitis and necrotizing granuloma that commonly affects the upper and lower respiratory tract and kidneys. Audiovestibular dysfunction in GPA diseases may have different clinical presentations. The aim of the present study was to evaluate hearing function in patients with GPA and to compare the results with a healthy control group. Materials and Methods : A total of 34 individuals participated in the study...
February 3, 2024: Medicina
https://read.qxmd.com/read/38393328/benralizumab-versus-mepolizumab-for-eosinophilic-granulomatosis-with-polyangiitis
#39
JOURNAL ARTICLE
Michael E Wechsler, Parameswaran Nair, Benjamin Terrier, Bastian Walz, Arnaud Bourdin, David R W Jayne, David J Jackson, Florence Roufosse, Lena Börjesson Sjö, Ying Fan, Maria Jison, Christopher McCrae, Sofia Necander, Anat Shavit, Claire Walton, Peter A Merkel
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by eosinophilic inflammation. Benralizumab, a monoclonal antibody against the interleukin-5α receptor expressed on eosinophils, may be an option for treating EGPA. METHODS: We conducted a multicenter, double-blind, phase 3, randomized, active-controlled noninferiority trial to evaluate the efficacy and safety of benralizumab as compared with mepolizumab. Adults with relapsing or refractory EGPA who were receiving standard care were randomly assigned in a 1:1 ratio to receive benralizumab (30 mg) or mepolizumab (300 mg) subcutaneously every 4 weeks for 52 weeks...
February 23, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38387195/maternal-and-fetal-outcomes-of-pregnancy-in-women-with-primary-systemic-vasculitis-a-single-center-cohort-study-of-20-patients-and-30-pregnancies
#40
JOURNAL ARTICLE
Sara Beça, Marco A Alba, José Hernández-Rodríguez, Georgina Espígol-Frigolé, Sergio Prieto-González, María C Cid, Núria Baños, Gerard Espinosa
OBJECTIVES: To analyze pregnancy outcomes of patients with primary systemic vasculitis followed in a third-level referral center. METHODS: Retrospective cohort study of all pregnant women with systemic vasculitis followed between 2009 and 2022 at the High-Risk Pregnancy Clinic of the Department of Systemic Autoimmune Diseases of the Hospital Clínic, Barcelona. RESULTS: Twenty women with primary vasculitis were identified, with a total of 30 pregnancies...
February 14, 2024: Seminars in Arthritis and Rheumatism
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