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https://www.readbyqxmd.com/read/28209982/severe-decline-of-estimated-glomerular-filtration-rate-associates-with-progressive-cognitive-deterioration-in-the-elderly-a-community-based-cohort-study
#1
Yi-Chi Chen, Shuo-Chun Weng, Jia-Sin Liu, Han-Lin Chuang, Chih-Cheng Hsu, Der-Cherng Tarng
Cognitive dysfunction is closely related to aging and chronic kidney disease (CKD). However, the association between renal function changes and the risk of developing cognitive impairment has not been elucidated. This longitudinal cohort study was to determine the influence of annual percentage change in estimated glomerular filtration rate (eGFR) on subsequent cognitive deterioration or death of the elderly within the community. A total of 33,654 elders with eGFR measurements were extracted from the Taipei City Elderly Health Examination Database...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196295/association-of-pre-transplant-kidney-function-with-outcomes-after-lung-transplantation
#2
Amit Banga, Manish Mohanka, Jessica Mullins, Srinivas Bollineni, Vaidehi Kaza, Fernando Torres, Bekir Tanriover
PURPOSE: There is a lack of data regarding the independent association of pre-transplant kidney function with early and late outcomes among lung transplant (LT) recipients. METHODS: We queried the UNOS database for adult patients (≥ 18 years of age) undergoing LT between 1987 and 2013. Glomerular filtration rate (GFR) was estimated using the Modification of diet in renal disease (MDRD) and the Chronic kidney disease epidemiology collaboration (CKD-EPI) equations...
February 14, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28195182/prognostic-significance-of-left-ventricular-mass-index-and-renal-function-decline-rate-in-chronic-kidney-disease-g3-and-g4
#3
Jiun-Chi Huang, Szu-Chia Chen, Yi-Chun Tsai, I-Ching Kuo, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
The effect of left ventricular mass index (LVMI) and estimated glomerular filtration rate (eGFR) decline rate on outcome prediction in patients with chronic kidney disease (CKD) remains unclear. We included 306 CKD G3 and G4 patients with LVMI assessed through echocardiography. Rapid decline in renal function was defined as the eGFR slope <-3 mL/min/1.73 m(2)/year. Patients were stratified into four groups using sex-specific median values of LVMI and rapid eGFR decline. The composite outcome was progression to maintenance dialysis or death...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28191531/urine-biomarkers-in-renal-allograft
#4
Hongting Wang, Zuan-Tao Lin, Yulin Yuan, Tianfu Wu
There is a high risk for the survival of patients with an end-stage renal disease for kidney transplantation. To avoid rejection by strict medication adherence is of utmost importance to avoid the failure of a kidney transplant. It is imperative to develop non-invasive biomarkers to assess immunity risk, and to ultimately provide guidance for therapeutic decision-making following kidney transplantation. Urine biomarkers may represent the promising non-invasive tools that will help in predicting risk or success rates of kidney transplantations...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28191529/the-green-tea-polyphenol-epigallocatechin-3-gallate-and-its-beneficial-roles-in-chronic-kidney-disease
#5
REVIEW
Hui Bao, Ai Peng
Chronic kidney disease (CKD), a condition that affects around 10% of the population, has become a significant public health concern. Current therapeutic strategies to slow down the progression of CKD remain limited. Thus, it is urgent to develop new strategies to manage the patients with CKD. Work within the past decade has improved our understanding of the mechanisms contributing to CKD. In particular, oxidative stress as well as inflammation appears to play a pivotal role in CKD progression. ()-Epigallocatechin-3-gallate (EGCG), the major catechin of green tea extract, is known as a powerful antioxidant and reactive oxygen species scavenger...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28189120/does-the-opg-rankl-system-contribute-to-the-bone-vascular-axis-in-chronic-kidney-disease-a-systematic-review
#6
REVIEW
Beata Znorko, Ewa Oksztulska-Kolanek, Małgorzata Michałowska, Tomasz Kamiński, Krystyna Pawlak
Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD) and is strongly associated with cardiovascular mortality and morbidity. Accumulating evidence over the past decade has challenged the hypothesis of close interaction between bone and VC what raises the possibility of a common underlying pathophysiological mechanism. Lately, bone regulatory proteins such as: osteoprotegerin (OPG) and Receptor Activator for Nuclear Factor κB Ligand (RANKL) has attracted attention of researchers as a possible key mediators of bone-vascular calcification imbalance...
February 8, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28187786/low-renal-replacement-therapy-incidence-among-slowly-progressing-elderly-chronic-kidney-disease-patients-referred-to-nephrology-care-an-observational-study
#7
Ulrika Hahn Lundström, Alessandro Gasparini, Rino Bellocco, Abdul Rashid Qureshi, Juan-Jesus Carrero, Marie Evans
BACKGROUND: Elderly patients with advanced chronic kidney disease (CKD) have a high risk of death before reaching end-stage kidney disease. In order to allocate resources, such as advanced care nephrology where it is most needed, it is essential to know which patients have the highest absolute risk of advancing to renal replacement therapy (RRT). METHODS: We included all nephrology-referred CKD stage 3b-5 patients in Sweden 2005-2011 included in the Swedish renal registry (SRR-CKD) who had at least two serum creatinine measurements one year apart (+/- 6 months)...
February 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28187016/improving-outcomes-for-patients-with-chronic-kidney-disease-part-2
#8
Jenna M Norton, Eileen P Newman, Gayle Romancito, Stephanie Mahooty, Theresa Kuracina, Andrew S Narva
: Addressing disease complications and treatment for kidney failure: a clinical review. ABSTRACT: Coping with chronic kidney disease (CKD) is challenging for many people, since symptoms often don't appear until the disease is advanced and the patient is close to requiring dialysis. This two-part article aims to provide nurses with the basic information necessary to assess and manage patients with CKD. Part 1, which appeared last month, offered an overview of the disease, described identification and etiology, and discussed ways to slow disease progression...
February 9, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28186657/association-of-vitamin-d-metabolites-with-parathyroid-hormone-fibroblast-growth-factor-23-calcium-and-phosphorus-in-dogs-with-various-stages-of-chronic-kidney-disease
#9
V J Parker, L M Harjes, K Dembek, G S Young, D J Chew, R E Toribio
BACKGROUND: Hypovitaminosis D is associated with progression of renal disease, development of renal secondary hyperparathyroidism (RHPT), chronic kidney disease-mineral bone disorder (CKD-MBD), and increased mortality in people with CKD. Despite what is known regarding vitamin D dysregulation in humans with CKD, little is known about vitamin D metabolism in dogs with CKD. OBJECTIVES: The purpose of our study was to further elucidate vitamin D status in dogs with different stages of CKD and to relate it to factors that affect the development of CKD-MBD, including parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), calcium, and phosphorus concentrations...
February 10, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28185787/progression-of-renal-fibrosis-in-congenital-ckd-model-rats-with-reduced-number-of-nephrons
#10
Hidenori Yasuda, Yuki Tochigi, Kentaro Katayama, Hiroetsu Suzuki
A congenital reduction in the number of nephrons is a critical risk factor for both onset of chronic kidney disease (CKD) and its progression to end-stage kidney disease (ESKD). Hypoplastic kidney (HPK) rats have only about 20% of the normal number of nephrons and show progressive CKD. This study used an immunohistological method to assess glomerular and interstitial pathogenesis in male HPK rats aged 35-210days. CD68 positive-macrophages were found to infiltrate into glomeruli in HPK rats aged 35 and 70days and to infiltrate into interstitial tissue in rats aged 140 and 210days...
February 6, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28182038/study-of-anemia-in-nondialysis-dependent-chronic-kidney-disease-with-special-reference-to-serum-hepcidin
#11
H Goyal, S Mohanty, M Sharma, A Rani
We studied the role of serum hepcidin in anemia of chronic kidney disease (CKD) in a hospital-based cross-sectional study. Serum hepcidin, ferritin, and high-sensitivity C-reactive protein (hsCRP) levels were evaluated in patients of CKD. Hepcidin levels were increased in patients as compared to healthy adults. Hepcidin levels increased as CKD progressed through stage 3-5 (P trend = 0.015) but did not correlate with estimated glomerular filtration rate. Hepcidin correlated positively with ferritin (P < 0...
January 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28179401/high-serum-soluble-cd200-levels-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#12
Funda Sari, Saadet Gumuslu, Ramazan Cetinkaya, Metin Sarikaya, Arzu Didem Yalcin
CD200 is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in a soluble form in serum, which performs to modulate inflammatory and acquired immune responses. Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of large renal cysts and progressive loss of renal function. As defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in ADPKD, we asked whether serum soluble CD200 might underlie and effect on ADPKD...
February 8, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28178330/comparative-study-of-extrapolative-factors-linked-with-oxidative-injury-and-anti-inflammatory-status-in-chronic-kidney-disease-patients-experiencing-cardiovascular-distress
#13
Mahmood Rasool, Muhammad Abdul Basit Ashraf, Arif Malik, Sulayman Waquar, Shahida Aziz Khan, Mahmood Husain Qazi, Waseem Ahmad, Muhammad Asif, Sami Ullah Khan, Ahmad Zaheer, Muther Mansoor Qaisrani, Abdul Rehman Khan, Aamir Iqbal, Amir Raza, Saima Iram, Kashif Kamran, Asim Iqbal, Mohammad Zahid Mustafa, Hani Choudhry, Mazin A Zamzami, Wesam H Abdulaal, Mohammad Sarwar Jamal
BACKGROUND: Chronic kidney disease (CKD) is a group of heterogeneous abnormalities affecting the function and structure of the kidney and mostly further proceeds to cardiovascular damage prior to end stage renal disease (ESRD). The oxidative insult and inflammatory mediators have some undefined role in CKD and cardiovascular complications. It is therefore, aimed at to pin point the predictive factors in the development of cardiovascular disorder in patients with chronic kidney disease...
2017: PloS One
https://www.readbyqxmd.com/read/28178182/effects-of-magnesium-on-the-phosphate-toxicity-in-chronic-kidney-disease-time-for-intervention-studies
#14
REVIEW
Yusuke Sakaguchi, Takayuki Hamano, Yoshitaka Isaka
Magnesium, an essential mineral for human health, plays a pivotal role in the cardiovascular system. Epidemiological studies in the general population have found an association between lower dietary magnesium intake and an elevated risk of cardiovascular events. In addition, magnesium supplementation was shown to improve blood pressure control, insulin sensitivity, and endothelial function. The relationship between magnesium and cardiovascular prognosis among patients with chronic kidney disease (CKD) has been increasingly investigated as it is becoming evident that magnesium can inhibit vascular calcification, a prominent risk of cardiovascular events, which commonly occurs in CKD patients...
February 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28177092/-newer-anti-diabetic-therapies-and-chronic-kidney-disease
#15
Luca Di Lullo, Claudio Ronco, Vincenzo Barbera, Mario Cozzolino, Francesca Santoboni, Annalisa Villani, Antonio De Pascalis, Antonio Bellasi
Worldwide, an estimated 200 million people have chronic kidney disease (CKD), whose most common causes include hypertension, arteriosclerosis, and diabetes. About 40% of patients with diabetes develop CKD. Intensive blood glucose control through pharmacological intervention can delay CKD progression. Standard therapies for the treatment of type 2 diabetes include metformin, sulfonylureas, meglitinides, thiazolidinediones and insulin. While these drugs have an important role in the management of type 2 diabetes, only the thiazolidinedione pioglitazone can be used across the spectrum of CKD (stages 25) and without dose adjustment...
January 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28174659/making-an-impakt-improving-care-of-chronic-kidney-disease-patients-in-the-community-through-collaborative-working-and-utilizing-information-technology
#16
Gang Xu, Rupert Major, David Shepherd, Nigel Brunskill
Chronic kidney disease (CKD) is a serious long-term condition, which if left untreated causes significant cardiovascular sequele. It is well recognized management of modifiable risk factors, such as blood pressure (BP), can lead to improved long-term outcomes. A novel information technology (IT) solution presents a possible solution to help clinicians in the community identify and manage at risk patients more efficiently. The IMproving Patient care and Awareness of Kidney disease progression Together (IMPAKT) IT tool was used to identify patients with CKD and uncontrolled hypertension in the community...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28174318/integrating-quality-improvement-education-into-the-nephrology-curricular-milestones-framework-and-the-clinical-learning-environment-review
#17
Lisa K Prince, Dustin J Little, Katherine I Schexneider, Christina M Yuan
The Accreditation Council for Graduate Medical Education requires that trainees show progressive milestone attainment in the practice-based learning and systems-based practice competencies. As part of the Clinical Learning Environment Review, sponsoring hospitals must educate trainees in health care quality improvement, provide them with specialty-specific quality data, and ensure trainee participation in quality improvement activities and committees. Subspecialty-specific quality improvement curricula in nephrology training programs have not been reported, although considerable curricular and assessment material exists for specialty residencies, including tools for assessing trainee and faculty competence...
February 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28164673/nuclear-respiratory-factor-1-nrf-1-gene-expression-in-chronic-kidney-disease-patients-undergoing-hemodialysis-and-mitochondrial-oxidative-dysregulation
#18
Doaa Hashad, Iman Elgohry, Fatma Dwedar
BACKGROUND: Chronic kidney disease (CKD) is characterized by progressive irreversible deterioration of renal functions. Advanced stages of CKD are associated with oxidative stress due to the imbalance between oxidant production and antioxidant defense mechanisms. Survival of patients with end stage renal diseases is maintained on variable forms of renal replacement therapies (RRT) which include peritoneal dialysis, hemodialysis, and sometimes renal transplantation. In humans, Nuclear Respiratory Factor 1 (NRF-1) gene encodes for a transcription factor that, together with the transcriptional co-activator encoded by Peroxisome Proliferator activated Receptor Gamma coactivator 1 Alpha (PGC1-a) gene, stimulates the expression of a broad set of nuclear genes (as COX6C) which are involved in mitochondrial biogenesis and functions...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164170/ambulatory-blood-pressure-in-chronic-kidney-disease-ready-for-prime-time
#19
Manuel T Velasquez, Srinivasan Beddhu, Ehsan Nobakht, Mahboob Rahman, Dominic S Raj
Hypertension is common in patients with chronic kidney disease (CKD) and is the most important modifiable risk factor for CKD progression and adverse cardiovascular events in these patients. Diagnosis and successful management of hypertension are critically dependent on accurate blood pressure (BP) measurement. This is most relevant to CKD patients, in whom BP control is difficult to achieve and in whom early antihypertensive treatment is imperative to prevent kidney and cardiovascular complications. Accumulated data indicate that ambulatory blood pressure monitoring (ABPM) is better in detecting hypertension than office BP measurement...
July 2016: KI Reports
https://www.readbyqxmd.com/read/28161698/adenine-rich-diet-is-not-a-surrogate-of-5-6-nephrectomy-in-rabbits
#20
Nans Florens, Sandrine Lemoine, Caroline C Pelletier, Maud Rabeyrin, Laurent Juillard, Christophe O Soulage
BACKGROUND: Animal models are important tools needed to understand the mechanisms underlying the progression of renal disease and to implement new therapeutic approaches. A non-surgical model of chronic kidney disease (CKD) developed by chemical nephrectomy using an adenine-enriched diet has been shown to be a robust model to induce kidney failure in mice and rats. The purpose of this study was to implement an adenine diet to induce CKD in rabbits. METHODS: Male New Zealand rabbits were fed for 4 weeks with a diet containing 0...
February 4, 2017: Nephron
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