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https://www.readbyqxmd.com/read/29773334/plague-bridging-gaps-towards-better-disease-control
#1
REVIEW
E D'Ortenzio, N Lemaître, C Brouat, P Loubet, F Sebbane, M Rajerison, L Baril, Y Yazdanpanah
After centuries of epidemics and more than a hundred years since the identification of the causative bacterium, very little is known about the plague dynamics in animal reservoirs, vectors and the changing vulnerabilities for humans. The recent plague epidemic in Madagascar in 2017 highlights these gaps existing within the knowledge of the disease dynamics, the factors influencing it, the performance of diagnostic tests and the best recommended treatment. As the eradication of plague will not be possible due to the widespread existence of the bacterium in wildlife, a One Health approach, drawing on animal, human and environmental health disciplines is needed to better control this poverty-related disease...
May 14, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29715287/multisectoral-prioritization-of-zoonotic-diseases-in-uganda-2017-a-one-health-perspective
#2
Musa Sekamatte, Vikram Krishnasamy, Lilian Bulage, Christine Kihembo, Noelina Nantima, Fred Monje, Deo Ndumu, Juliet Sentumbwe, Betty Mbolanyi, Robert Aruho, Winyi Kaboyo, David Mutonga, Colin Basler, Sarah Paige, Casey Barton Behravesh
BACKGROUND: Zoonotic diseases continue to be a public health burden globally. Uganda is especially vulnerable due to its location, biodiversity, and population. Given these concerns, the Ugandan government in collaboration with the Global Health Security Agenda conducted a One Health Zoonotic Disease Prioritization Workshop to identify zoonotic diseases of greatest national concern to the Ugandan government. MATERIALS AND METHODS: The One Health Zoonotic Disease Prioritization tool, a semi-quantitative tool developed by the U...
2018: PloS One
https://www.readbyqxmd.com/read/29713474/the-belgian-commitment-to-pharmaceutical-quality-a-model-policy-to-improve-quality-assurance-of-medicines-available-through-humanitarian-and-development-programs
#3
EDITORIAL
Raffaella Ravinetto, Tim Roosen, Catherine Dujardin
Today, a combination of globalization of pharmaceutical production, lack of regulatory harmonization, and weakness of Medicines Regulatory Authorities, creates the "perfect conditions" for poor-quality medicine to circulate in the global market and to penetrate the less-regulated countries. Medicines regulation is the responsibility of the national regulatory authorities in the recipient country, but in the poorer countries, in practice, the responsibility of supply of quality-assured medicines is often taken by Non-Governmental Organizations and other implementers...
2018: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29295017/client-violence-against-youth-care-workers-findings-of-an-exploratory-study-of-workforce-issues-in-residential-treatment
#4
Yvonne Smith, Lex Colletta, Anna E Bender
Residential treatment centers (RTCs) for youth are plagued by high turnover of youth care workers who provide round-the-clock treatment and supervision to youth with severe affective and behavioral problems. This article presents findings from a 15-month ethnographic study of workforce issues in one RTC related to youth care workers' exposure to client violence (CV). Findings are based on 65 semistructured interviews and 490 hours of participant observation with consenting employees. Participants reported CV incidents, including punching, kicking, biting, hair pulling, choking, threats or assaults with a weapon, and other physical and sexualized violence...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29261673/we-are-what-we-eat-regulatory-gaps-in-the-united-states-that-put-our-health-at-risk
#5
Maricel V Maffini, Thomas G Neltner, Sarah Vogel
The American diet has changed dramatically since 1958, when Congress gave the United States Food and Drug Administration (FDA) the authority to ensure the safety of chemicals in food. Since then, thousands of chemicals have entered the food system. Yet their long-term, chronic effects have been woefully understudied, their health risks inadequately assessed. The FDA has been sluggish in considering scientific knowledge about the impact of exposures-particularly at low levels and during susceptible developmental stages...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29110719/plague-risk-in-vulnerable-community-assessment-of-xenopsylla-cheopis-susceptibility-to-insecticides-in-malagasy-prisons
#6
Adélaïde Miarinjara, Jean Vergain, Jean Marcel Kavaruganda, Minoarisoa Rajerison, Sébastien Boyer
BACKGROUND: Prisons in Madagascar are at high risk of plague outbreak. Occurrence of plague epidemic in prisons can cause significant episode of urban plague through the movement of potentially infected humans, rodents and fleas. Rodent and flea controls are essential in plague prevention, by reducing human contact with plague reservoirs and vectors. Insecticide treatment is the key step available for the control of rat fleas which transmit the disease from infected rodents to human. The implementation of an adapted flea control strategy should rely on the insecticide susceptibility status of the targeted population...
November 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28734784/drug-delivery-innovations-to-address-global-health-challenges-for-pediatric-and-geriatric-populations-through-improvements-in-patient-compliance
#7
Joshua Boateng
Despite significant advances in pharmaceutical and biotechnological drug discovery, the global population is plagued with many challenging diseases. These are further compounded by anticipated explosion in an ageing population, which presents several problems such as polypharmacy, dysphagia, and neurologic conditions, resulting in noncompliance and disease complications. For antibiotics, poor compliance, can result in development of drug-resistant infections which can be fatal. Furthermore, children, especially, in developing countries die unnecessarily from easily treatable diseases (e...
July 20, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28711342/birmingham-hip-resurfacing-vs-total-hip-arthroplasty-a-matched-pair-comparison-of-clinical-outcomes
#8
Victor R Ortiz-Declet, David A Iacobelli, Leslie C Yuen, Itay Perets, Austin W Chen, Benjamin G Domb
BACKGROUND: Birmingham hip resurfacing (BHR) has proven to be a good alternative for younger patients with osteoarthritis. Some have asserted that BHR may yield outcomes which are superior to total hip arthroplasty (THA), and that some studies which failed to show a difference were plagued by ceiling effects and lack of sensitivity of outcome measures. The purpose of this study is to compare outcomes of BHR and THA using the "Forgotten Joint" Score-12 (FJS), a more sensitive score with lesser vulnerability to the ceiling effect...
December 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28569291/misadventure-in-muirhouse-hiv-infection-a-modern-plague-and-persisting-public-health-problem
#9
R Robertson
This story is of particular interest and importance to Edinburgh and Scottish medicine. It describes the events in one general medical practice in Edinburgh, the Muirhouse Medical Group, and their impact and relationship to the AIDS pandemic. For many, the origin of HIV in the UK is now history. Since the introduction of HIV/AIDS into the intravenous illegal drug using community, much has changed but problems remain that should concern policy makers and clinicians. Reflections on the recent history of the HIV epidemic among drug users in the UK provide important insights into risks for current policy making and the potentially problematic direction that policy has taken...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28451245/protecting-micrornas-from-rnase-degradation-with-steric-dna-nanostructures
#10
H Qian, C Y Tay, M I Setyawati, S L Chia, D S Lee, D T Leong
Tumor suppressive microRNAs are potent molecules that might cure cancer, one day. Despite the many advanced strategies for delivery of these microRNAs to the cell, there are few therapeutic microRNAs in clinical use. Progress in microRNA bioapplications is hindered by a high vulnerability of exogeneous microRNA molecules to RNase degradation that occurs in extra- and intracellular physiological conditions. In this proof-of-concept study, we use a programmable self-assembled DNA nanostructure bearing a "shuriken" shape to not only deliver but more importantly protect a tumor suppressive microRNA-145 for a sufficiently long time to exert its therapeutic effect in human colorectal cancer cells...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28320263/duck-virus-enteritis-duck-plague-a-comprehensive-update
#11
REVIEW
Kuldeep Dhama, Naveen Kumar, Mani Saminathan, Ruchi Tiwari, Kumaragurubaran Karthik, M Asok Kumar, M Palanivelu, Muhammad Zubair Shabbir, Yashpal Singh Malik, Raj Kumar Singh
Duck virus enteritis (DVE), also called duck plague, is one of the major contagious and fatal diseases of ducks, geese and swan. It is caused by duck enteritis virus (DEV)/Anatid herpesvirus-1 of the genus Mardivirus, family Herpesviridae, and subfamily Alpha-herpesvirinae. Of note, DVE has worldwide distribution, wherein migratory waterfowl plays a crucial role in its transmission within and between continents. Furthermore, horizontal and/ or vertical transmission plays a significant role in disease spread through oral-fecal discharges...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28262733/network-theory-may-explain-the-vulnerability-of-medieval-human-settlements-to-the-black-death-pandemic
#12
José M Gómez, Miguel Verdú
Epidemics can spread across large regions becoming pandemics by flowing along transportation and social networks. Two network attributes, transitivity (when a node is connected to two other nodes that are also directly connected between them) and centrality (the number and intensity of connections with the other nodes in the network), are widely associated with the dynamics of transmission of pathogens. Here we investigate how network centrality and transitivity influence vulnerability to diseases of human populations by examining one of the most devastating pandemic in human history, the fourteenth century plague pandemic called Black Death...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28132598/the-narcissism-spectrum-model-a-synthetic-view-of-narcissistic-personality
#13
Zlatan Krizan, Anne D Herlache
The narcissism spectrum model synthesizes extensive personality, social-psychological, and clinical evidence, building on existing knowledge about narcissistic grandiosity and vulnerability to reveal a view of narcissism that respects its clinical origins, embraces the diversity and complexity of its expression, and reflects extensive scientific evidence about the continuity between normal and abnormal personality expression. Critically, the proposed model addresses three key, inter-related problems that have plagued narcissism scholarship for more than a century...
February 2018: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/28121134/molecular-imaging-of-vulnerable-atherosclerotic-plaques-in-vivo-with-osteopontin-specific-upconversion-nanoprobes
#14
Ruirui Qiao, Hongyu Qiao, Yan Zhang, Yabin Wang, Chongwei Chi, Jie Tian, Lifang Zhang, Feng Cao, Mingyuan Gao
Owing to the high mortality rate of cardiovascular diseases, developing novel noninvasive diagnostic methods becomes urgent and mandatory. It is well-known that the rupture of vulnerable plaques directly leads to deadly consequences. However, differentiating vulnerable plaques from stable plaques remains challenging in the clinic. In the current study, osteopontin (OPN), a secreted biomarker associated with macrophages and foamy macrophages, was selected as a target for identifying the vulnerable plaques. A dual modality imaging probe was constructed by covalently attaching an OPN antibody to NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/27355784/peer-support-for-clinicians-a-programmatic-approach
#15
Jo Shapiro, Pamela Galowitz
Burnout is plaguing the culture of medicine and is linked to several primary causes including long work hours, increasingly burdensome documentation, and resource constraints. Beyond these, additional emotional stressors for physicians are involvement in an adverse event, especially one that involves a medical error, and malpractice litigation. The authors argue that it is imperative that health care institutions devote resources to programs that support physician well-being and resilience. Doing so after adverse and other emotionally stressful events, such as the death of a colleague or caring for victims of a mass trauma, is crucial as clinicians are often at their most vulnerable during such times...
September 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27228555/multidrug-resistant-organisms-in-liver-transplant-mitigating-risk-and-managing-infections
#16
REVIEW
Jonathan Hand, Gopi Patel
Liver transplant (LT) recipients are vulnerable to infections with multidrug-resistant (MDR) pathogens. Risk factors for colonization and infection with resistant bacteria are ubiquitous and unavoidable in transplantation. During the past decade, progress in transplantation and infection prevention has contributed to the decreased incidence of infections with methicillin-resistant Staphylococcus aureus. However, even in the face of potentially effective antibiotics, vancomycin-resistant enterococci continue to plague LT...
August 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27206731/global-health-partnerships-building-multi-national-collaborations-to-achieve-lasting-improvements-in-maternal-and-neonatal-health
#17
Rohit Ramaswamy, Brianne Kallam, Dragica Kopic, Borislava Pujic, Medge D Owen
BACKGROUND: In response to health care challenges worldwide, extensive funding has been channeled to the world's most vulnerable health systems. Funding alone is not sufficient to address the complex issues and challenges plaguing these health systems. To see lasting improvement in maternal and infant health outcomes in the developing world, a global commitment to the sharing of knowledge and resources through international partnerships is critical. But partnerships that merely introduce western medical techniques and protocols to low resource settings, without heeding the local contexts, are misguided and unsustainable...
May 20, 2016: Globalization and Health
https://www.readbyqxmd.com/read/26875531/availability-a-metric-for-nucleic-acid-strand-displacement-systems
#18
Xiaoping Olson, Shohei Kotani, Jennifer E Padilla, Natalya Hallstrom, Sara Goltry, Jeunghoon Lee, Bernard Yurke, William L Hughes, Elton Graugnard
DNA strand displacement systems have transformative potential in synthetic biology. While powerful examples have been reported in DNA nanotechnology, such systems are plagued by leakage, which limits network stability, sensitivity, and scalability. An approach to mitigate leakage in DNA nanotechnology, which is applicable to synthetic biology, is to introduce mismatches to complementary fuel sequences at key locations. However, this method overlooks nuances in the secondary structure of the fuel and substrate that impact the leakage reaction kinetics in strand displacement systems...
January 20, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/26867286/gender-differences-in-respiratory-health-of-school-children-exposed-to-rail-yard-generated-air-pollution-the-enrrich-study
#19
Rhonda Spencer-Hwang, Sam Soret, Mark Ghamsary, Nico Rizzo, Marti Baum, David Juma, Susanne Montgomery
Studies about environmental burdens often explore overall community risk. Increasing evidence suggests, however, differential burdens by gender and age. The purpose of the authors' research was to determine if gender-related difference exists among children in a region plagued with poor air quality and if increased exposure to pollutants from a major goods movement rail yard influences the relationship. Using a cross-sectional study design, the authors provided respiratory screening for children at two elementary schools...
January 2016: Journal of Environmental Health
https://www.readbyqxmd.com/read/26737811/a-look-at-the-strength-of-micro-and-macro-eeg-analysis-for-distinguishing-insomnia-within-an-hiv-cohort
#20
Kristin M Gunnarsdottir, Yu Min Kang, Matthew S D Kerr, Sridevi V Sarma, Joshua Ewen, Richard Allen, Charlene Gamaldo, Rachel M E Salas
HIV patients are often plagued by sleep disorders and suffer from sleep deprivation. However, there remains a wide gap in our understanding of the relationship between HIV status, poor sleep, overall function and future outcomes; particularly in the case of HIV patients otherwise well controlled on cART (combined anti-retroviral therapy). In this study, we compared two groups: 16 non-HIV subjects (seronegative controls) and 12 seropositive HIV patients with undetectable viral loads. We looked at sleep behavioral (macro-sleep) features and sleep spectral (micro-sleep) features obtained from human-scored overnight EEG recordings to study whether the scored EEG data can be used to distinguish between controls and HIV subjects...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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