Zhongchen Song, Chao Liu, Junichi Iwata, Shuping Gu, Akiko Suzuki, Cheng Sun, Wei He, Rong Shu, Lu Li, Yang Chai, YiPing Chen
Cleft palate represents one of the most common congenital birth defects in humans. TGFβ signaling, which is mediated by Smad-dependent and Smad-independent pathways, plays a crucial role in regulating craniofacial development and patterning, particularly in palate development. However, it remains largely unknown whether the Smad-independent pathway contributes to TGFβ signaling function during palatogenesis. In this study, we investigated the function of TGFβ activated kinase 1 (Tak1), a key regulator of Smad-independent TGFβ signaling in palate development...
April 12, 2013: Journal of Biological Chemistry