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https://www.readbyqxmd.com/read/29210932/score-distributions-of-the-balance-outcome-measure-for-elder-rehabilitation-boomer-in-community-dwelling-older-adults-with-vertebral-fracture
#1
Zachary M Brown, Jenna C Gibbs, Jonathan D Adachi, Maureen C Ashe, Keith D Hill, David L Kendler, Aliya Khan, Alexandra Papaioannou, Sadhana Prasad, John D Wark, Lora M Giangregorio
BACKGROUND AND PURPOSE: We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-dwelling women 65 years and older with vertebral fracture and to describe score distributions and potential ceiling and floor effects. METHODS: This was a secondary data analysis of baseline data from the Build Better Bones with Exercise randomized controlled trial using the BOOMER. A total of 141 women with osteoporosis and radiographically confirmed vertebral fracture were included...
November 28, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29179144/the-centrality-of-dsm-and-non-dsm-depressive-symptoms-in-han-chinese-women-with-major-depression
#2
Kenneth S Kendler, Steven H Aggen, Jonathan Flint, Denny Borsboom, Eiko I Fried
INTRODUCTION: We compared DSM-IV criteria for major depression (MD) with clinically selected non-DSM criteria in their ability to represent clinical features of depression. METHOD: We conducted network analyses of 19 DSM and non-DSM symptoms of MD assessed at personal interview in 5952 Han Chinese women meeting DSM-IV criteria for recurrent MD. We estimated an Ising model (the state-of-the-art network model for binary data), compared the centrality (interconnectedness) of DSM-IV and non-DSM symptoms, and investigated the community structure (symptoms strongly clustered together)...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29173194/sex-similarities-and-differences-in-risk-factors-for-recurrence-of-major-depression
#3
Hanna M van Loo, Steven H Aggen, Charles O Gardner, Kenneth S Kendler
BACKGROUND: Major depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms. METHODS: We used prospective data from a general population sample (n = 653) that experienced a recent episode of MD...
November 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29173193/polygenic-prediction-of-the-phenome-across-ancestry-in-emerging-adulthood
#4
Anna R Docherty, Arden Moscati, Danielle Dick, Jeanne E Savage, Jessica E Salvatore, Megan Cooke, Fazil Aliev, Ashlee A Moore, Alexis C Edwards, Brien P Riley, Daniel E Adkins, Roseann Peterson, Bradley T Webb, Silviu A Bacanu, Kenneth S Kendler
BACKGROUND: Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes. METHODS: This study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes...
November 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29172241/the-impact-of-resilience-and-subsequent-stressful-life-events-on-mdd-and-gad
#5
Christina M Sheerin, Mackenzie J Lind, Emily A Brown, Charles O Gardner, Kenneth S Kendler, Ananda B Amstadter
BACKGROUND: There remains a dearth of research examining the "buffering" effect of resilience, wherein resilience at one point in time would be expected to protect an individual against development of psychopathology following future adverse life events. METHODS: Using longitudinal data from an epidemiological twin sample (N = 7463), this study tested whether resilience would act as a buffer for stressful life events (SLEs) against risk for major depressive disorder (MDD) and generalized anxiety disorder (GAD)...
November 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29165678/the-genealogy-of-dementia-praecox-i-signs-and-symptoms-of-delusional-psychoses-from-1880-to-1900
#6
Kenneth S Kendler
We can trace, with high congruence, the clinical syndromes of depression and mania as described over the 20th century in psychiatric textbooks back to 1880 and to the earliest writing of Kraepelin published in 1883. However, this is not the case for Kraepelin's 2 delusional syndromes central to his overall nosology: Dementia Paranoides (later paranoid schizophrenia) and Paranoia. A detailed examination of 28 textbook descriptions of delusional psychoses from 1880 to 1900 reveals a diverse and partially overlapping set of syndromes with an admixture of symptoms and signs that would later be considered indicative of Dementia Paranoides and Paranoia...
November 19, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29155917/associations-between-divorce-and-onset-of-drug-abuse-in-a-swedish-national-sample
#7
Alexis C Edwards, Sara Larsson Lönn, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
No abstract text is available yet for this article.
November 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29132074/robust-symptom-networks-in-recurrent-major-depression-across-different-levels-of-genetic-and-environmental-risk
#8
H M van Loo, C D Van Borkulo, R E Peterson, E I Fried, S H Aggen, D Borsboom, K S Kendler
BACKGROUND: Genetic risk and environmental adversity-both important risk factors for major depression (MD)-are thought to differentially impact on depressive symptom types and associations. Does heterogeneity in these risk factors result in different depressive symptom networks in patients with MD? METHODS: A clinical sample of 5784 Han Chinese women with recurrent MD were interviewed about their depressive symptoms during their lifetime worst episode of MD. The cases were classified into subgroups based on their genetic risk for MD (family history, polygenic risk score, early age at onset) and severe adversity (childhood sexual abuse, stressful life events)...
October 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29129436/effects-of-teriparatide-and-risedronate-on-new-fractures-in-post-menopausal-women-with-severe-osteoporosis-vero-a-multicentre-double-blind-double-dummy-randomised-controlled-trial
#9
David L Kendler, Fernando Marin, Cristiano A F Zerbini, Luis A Russo, Susan L Greenspan, Vit Zikan, Alicia Bagur, Jorge Malouf-Sierra, Péter Lakatos, Astrid Fahrleitner-Pammer, Eric Lespessailles, Salvatore Minisola, Jean Jacques Body, Piet Geusens, Rüdiger Möricke, Pedro López-Romero
BACKGROUND: No clinical trials have compared osteoporosis drugs with incident fractures as the primary outcome. We compared the anti-fracture efficacy of teriparatide with risedronate in patients with severe osteoporosis. METHODS: In this double-blind, double-dummy trial, we enrolled post-menopausal women with at least two moderate or one severe vertebral fracture and a bone mineral density T score of less than or equal to -1·50. Participants were randomly assigned to receive 20 μg of teriparatide once daily plus oral weekly placebo or 35 mg of oral risedronate once weekly plus daily injections of placebo for 24 months...
November 9, 2017: Lancet
https://www.readbyqxmd.com/read/29097400/trauma-and-psychotic-experiences-transnational-data-from-the-world-mental-health-survey
#10
John J McGrath, Sukanta Saha, Carmen C W Lim, Sergio Aguilar-Gaxiola, Jordi Alonso, Laura H Andrade, Evelyn J Bromet, Ronny Bruffaerts, José M Caldas de Almeida, Graça Cardoso, Giovanni de Girolamo, John Fayyad, Silvia Florescu, Oye Gureje, Josep M Haro, Norito Kawakami, Karestan C Koenen, Viviane Kovess-Masfety, Sing Lee, Jean-Pierre Lepine, Katie A McLaughlin, Maria E Medina-Mora, Fernando Navarro-Mateu, Akin Ojagbemi, Jose Posada-Villa, Nancy Sampson, Kate M Scott, Hisateru Tachimori, Margreet Ten Have, Kenneth S Kendler, Ronald C Kessler
BackgroundTraumatic events are associated with increased risk of psychotic experiences, but it is unclear whether this association is explained by mental disorders prior to psychotic experience onset.AimsTo investigate the associations between traumatic events and subsequent psychotic experience onset after adjusting for post-traumatic stress disorder and other mental disorders.MethodWe assessed 29 traumatic event types and psychotic experiences from the World Mental Health surveys and examined the associations of traumatic events with subsequent psychotic experience onset with and without adjustments for mental disorders...
November 2, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29072781/diagnostic-and-genetic-overlap-of-three-common-mental-disorders-in-structured-interviews-and-health-registries
#11
F A Torvik, E Ystrom, K Gustavson, T H Rosenström, J G Bramness, N Gillespie, S H Aggen, K S Kendler, T Reichborn-Kjennerud
OBJECTIVE: To investigate whether diagnostic data from structured interviews, primary care and specialist care registries on major depressive disorder (MDD), anxiety disorders (AD) and alcohol use disorder (AUD) identify the same individuals, yield comparable comorbidity estimates and reflect the same genetic influences. METHODS: Registry data from primary and specialist care were available for 11 727 twins and diagnostic interview data for 2271 of these. We used logistic regression analyses and biometric modelling to investigate the overlap between the data sources...
October 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29024120/remodeling-and-modeling-based-bone-formation-with-teriparatide-versus-denosumab-a-longitudinal-analysis-from-baseline-to-3-months-in-the-ava-study
#12
David W Dempster, Hua Zhou, Robert R Recker, Jacques P Brown, Christopher P Recknor, E Michael Lewiecki, Paul D Miller, Sudhaker D Rao, David L Kendler, Robert Lindsay, John H Krege, Jahangir Alam, Kathleen A Taylor, Thomas E Melby, Valerie A Ruff
There has been renewed interest of late in the role of modeling-based formation (MBF) during osteoporosis therapy. Here we describe early effects of an established anabolic (teriparatide) versus antiresorptive (denosumab) agent on remodeling-based formation (RBF), MBF, and overflow MBF (oMBF) in human transiliac bone biopsies. Postmenopausal women with osteoporosis received subcutaneous teriparatide (n = 33, 20 μg/d) or denosumab (n = 36, 60 mg once/6 months), open-label for 6 months at 7 US and Canadian sites...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29017623/the-genealogy-of-the-clinical-syndrome-of-mania-signs-and-symptoms-described-in-psychiatric-texts-from-1880-to-1900
#13
K S Kendler
In 1800, mania was conceptualized as an agitated psychotic state. By 1900, it closely resembled its modern form. This paper reviews the descriptions of mania in Western psychiatry from 1880 to 1900, when Kraepelin was training and developing his concept of manic-depressive illness. Psychiatric textbooks published 1900-1960 described 22 characteristic manic symptoms/signs the presence of which were recorded in 25 psychiatric textbooks and three other key documents published 1880-1900. Descriptions of mania in these nineteenth century textbooks closely resembled those in the twentieth century, recording a mean (s...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28994361/prediction-of-drug-abuse-recurrence-a-swedish-national-study
#14
K S Kendler, H Ohlsson, K Sundquist, J Sundquist
BACKGROUND: Relapse from drug abuse (DA) is common, but has rarely been studied in general population samples using a wide range of objective predictors. METHOD: Using nationwide registries, we ascertained 44 523 subjects first registered for DA between the ages of 15 and 40 in 1998 to 2004 and followed for 8 years. We predicted relapse in subjects defined as a second DA registration. We also predicted DA relapse in relative pairs concordant for DA but discordant for relapse...
October 10, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28979972/causal-and-noncausal-processes-underlying-being-bullied
#15
Judy Silberg, Kenneth S Kendler
No abstract text is available yet for this article.
November 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28969721/polygenic-risk-for-severe-psychopathology-among-europeans-is-associated-with-major-depressive-disorder-in-han-chinese-women
#16
A C Edwards, A R Docherty, A Moscati, T B Bigdeli, R E Peterson, B T Webb, S-A Bacanu, J M Hettema, J Flint, K S Kendler
BACKGROUND: Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities. METHOD: The relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women...
October 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28968763/jepegmix2-improved-gene-level-joint-analysis-of-eqtls-in-cosmopolitan-cohorts
#17
Chris Chatzinakos, Donghyung Lee, Bradley T Webb, Vladimir I Vladimirov, Kenneth S Kendler, Silviu-Alin Bacanu
Motivation: To increase detection power, researchers use gene level analysis methods to aggregate weak marker signals. Due to gene expression controlling biological processes, researchers proposed aggregating signals for expression Quantitative Trait Loci (eQTL). Most gene-level eQTL methods make statistical inferences based on i) summary statistics from genome-wide association studies (GWAS) and ii) linkage disequilibrium (LD) patterns from a relevant reference panel. While most such tools assume homogeneous cohorts, our Gene-level Joint Analysis of functional SNPs in Cosmopolitan Cohorts (JEPEGMIX) method accommodates cosmopolitan cohorts by using heterogeneous panels...
September 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28956523/transmission-of-alcohol-use-disorder-across-three-generations-a-swedish-national-study
#18
K S Kendler, H Ohlsson, J Sundquist, K Sundquist
BACKGROUND: While risk for alcohol use disorder (AUD) is correlated in twins, siblings and parent-offspring pairs, we know little of how this syndrome is transmitted across three generations. METHOD: We examined 685 172 individuals born in Sweden from 1980 to 1990 with four grandparents, and both parents alive in 1980. AUD was assessed in all these individuals from nationwide medical, criminal and pharmacy registries. RESULTS: AUD was stably transmitted across three generations...
September 28, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28948577/somatostatin-receptor-subtype-1-might-be-a-predictor-of-better-response-to-therapy-in-medullary-thyroid-carcinoma
#19
Daniel Barretto Kendler, Mario Lucio Araújo, Renata Alencar, Maria Theresa de Souza Accioly, Daniel Alves Bulzico, Cencita Cordeiro de Noronha Pessoa, Fernanda Andrade Accioly, Terence Pires de Farias, Flaia Paiva Proença Lobo Lopes, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
PURPOSE: Medullary thyroid carcinoma (MTC) is a malignant neoplasm of parafollicular cells. Because it is a neuroendocrine tumor, it has known somatostatin receptors (SSTRs). The actual frequencies of the SSTR subtypes and their potential influences (by binding with endogenous somatostatin) on MTC cell proliferation have not been fully elucidated to date. The present study evaluated the occurrence of SSTR subtypes 1, 2, 3 and 5 as well as the possible role that each subtype plays in the clinical evolution of patients with MTC...
December 2017: Endocrine
https://www.readbyqxmd.com/read/28943065/nicotine-dependence-internalizing-symptoms-mood-variability-and-daily-tobacco-use-among-young-adult-smokers
#20
Cristina B Bares, Danielle M Dick, Kenneth S Kendler
INTRODUCTION: Cigarette use among young adults continues to rise. As young adults transition to college and assume other adult roles and responsibilities, they are at risk for the development of mental health problems and for the progression of substance use problems. Previous studies suggest that individual differences in negative and positive mood contribute to cigarette use in established college-aged smokers, but less is known whether fluctuations in mood influence daily cigarette use, controlling for trait levels of internalizing symptoms and nicotine dependence...
September 18, 2017: Addictive Behaviors
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