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https://www.readbyqxmd.com/read/29024120/remodeling-and-modeling-based-bone-formation-with-teriparatide-versus-denosumab-a-longitudinal-analysis-from-baseline-to-3-months-in-the-ava-study
#1
David W Dempster, Hua Zhou, Robert R Recker, Jacques P Brown, Christopher P Recknor, E Michael Lewiecki, Paul D Miller, Sudhaker D Rao, David L Kendler, Robert Lindsay, John H Krege, Jahangir Alam, Kathleen A Taylor, Thomas E Melby, Valerie A Ruff
There has been renewed interest of late in the role of modeling-based formation (MBF) during osteoporosis therapy. Here we describe early effects of an established anabolic (teriparatide) versus antiresorptive (denosumab) agent on remodeling-based formation (RBF), MBF, and overflow MBF (oMBF) in human transiliac bone biopsies. Postmenopausal women with osteoporosis received subcutaneous teriparatide (n = 33, 20 µg/day) or denosumab (n = 36, 60 mg once/6 months), open-label for 6 months at 7 US and Canadian sites...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29017623/the-genealogy-of-the-clinical-syndrome-of-mania-signs-and-symptoms-described-in-psychiatric-texts-from-1880-to-1900
#2
K S Kendler
In 1800, mania was conceptualized as an agitated psychotic state. By 1900, it closely resembled its modern form. This paper reviews the descriptions of mania in Western psychiatry from 1880 to 1900, when Kraepelin was training and developing his concept of manic-depressive illness. Psychiatric textbooks published 1900-1960 described 22 characteristic manic symptoms/signs the presence of which were recorded in 25 psychiatric textbooks and three other key documents published 1880-1900. Descriptions of mania in these nineteenth century textbooks closely resembled those in the twentieth century, recording a mean (s...
October 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28994361/prediction-of-drug-abuse-recurrence-a-swedish-national-study
#3
K S Kendler, H Ohlsson, K Sundquist, J Sundquist
BACKGROUND: Relapse from drug abuse (DA) is common, but has rarely been studied in general population samples using a wide range of objective predictors. METHOD: Using nationwide registries, we ascertained 44 523 subjects first registered for DA between the ages of 15 and 40 in 1998 to 2004 and followed for 8 years. We predicted relapse in subjects defined as a second DA registration. We also predicted DA relapse in relative pairs concordant for DA but discordant for relapse...
October 10, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28979972/causal-and-noncausal-processes-underlying-being-bullied
#4
Judy Silberg, Kenneth S Kendler
No abstract text is available yet for this article.
October 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28969721/polygenic-risk-for-severe-psychopathology-among-europeans-is-associated-with-major-depressive-disorder-in-han-chinese-women
#5
A C Edwards, A R Docherty, A Moscati, T B Bigdeli, R E Peterson, B T Webb, S-A Bacanu, J M Hettema, J Flint, K S Kendler
BACKGROUND: Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities. METHOD: The relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women...
October 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28968763/jepegmix2-improved-gene-level-joint-analysis-of-eqtls-in-cosmopolitan-cohorts
#6
Chris Chatzinakos, Donghyung Lee, Bradley T Webb, Vladimir I Vladimirov, Kenneth S Kendler, Silviu-Alin Bacanu
Motivation: To increase detection power, researchers use gene level analysis methods to aggregate weak marker signals. Due to gene expression controlling biological processes, researchers proposed aggregating signals for expression Quantitative Trait Loci (eQTL). Most gene-level eQTL methods make statistical inferences based on i) summary statistics from genome-wide association studies (GWAS) and ii) linkage disequilibrium (LD) patterns from a relevant reference panel. While most such tools assume homogeneous cohorts, our Gene-level Joint Analysis of functional SNPs in Cosmopolitan Cohorts (JEPEGMIX) method accommodates cosmopolitan cohorts by using heterogeneous panels...
September 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28956523/transmission-of-alcohol-use-disorder-across-three-generations-a-swedish-national-study
#7
K S Kendler, H Ohlsson, J Sundquist, K Sundquist
BACKGROUND: While risk for alcohol use disorder (AUD) is correlated in twins, siblings and parent-offspring pairs, we know little of how this syndrome is transmitted across three generations. METHOD: We examined 685 172 individuals born in Sweden from 1980 to 1990 with four grandparents, and both parents alive in 1980. AUD was assessed in all these individuals from nationwide medical, criminal and pharmacy registries. RESULTS: AUD was stably transmitted across three generations...
September 28, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28948577/somatostatin-receptor-subtype-1-might-be-a-predictor-of-better-response-to-therapy-in-medullary-thyroid-carcinoma
#8
Daniel Barretto Kendler, Mario Lucio Araújo, Renata Alencar, Maria Theresa de Souza Accioly, Daniel Alves Bulzico, Cencita Cordeiro de Noronha Pessoa, Fernanda Andrade Accioly, Terence Pires de Farias, Flaia Paiva Proença Lobo Lopes, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
PURPOSE: Medullary thyroid carcinoma (MTC) is a malignant neoplasm of parafollicular cells. Because it is a neuroendocrine tumor, it has known somatostatin receptors (SSTRs). The actual frequencies of the SSTR subtypes and their potential influences (by binding with endogenous somatostatin) on MTC cell proliferation have not been fully elucidated to date. The present study evaluated the occurrence of SSTR subtypes 1, 2, 3 and 5 as well as the possible role that each subtype plays in the clinical evolution of patients with MTC...
September 25, 2017: Endocrine
https://www.readbyqxmd.com/read/28943065/nicotine-dependence-internalizing-symptoms-mood-variability-and-daily-tobacco-use-among-young-adult-smokers
#9
Cristina B Bares, Danielle M Dick, Kenneth S Kendler
INTRODUCTION: Cigarette use among young adults continues to rise. As young adults transition to college and assume other adult roles and responsibilities, they are at risk for the development of mental health problems and for the progression of substance use problems. Previous studies suggest that individual differences in negative and positive mood contribute to cigarette use in established college-aged smokers, but less is known whether fluctuations in mood influence daily cigarette use, controlling for trait levels of internalizing symptoms and nicotine dependence...
September 18, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28942808/effects-of-excessive-alcohol-use-on-antisocial%C3%A2-behavior-across-adolescence-and%C3%A2-early-adulthood
#10
Gemma Hammerton, Liam Mahedy, Joseph Murray, Barbara Maughan, Alexis C Edwards, Kenneth S Kendler, Matthew Hickman, Jon Heron
OBJECTIVE: Antisocial behavior (ASB) decreases with age in most of the population; however, excessive alcohol use can inhibit the desistance process. This study investigated whether excessive early drinking might slow a young person's overall pattern of crime desistance compared with that of others ("between-person effects") and whether short-term increases in alcohol consumption might result in short-term increases in ASB ("within-person effects"). METHOD: Frequency of ASB and typical alcohol consumption were assessed repeatedly in young people 15 to 21 years old in a population-based birth cohort (Avon Longitudinal Study of Parents and Children)...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28806639/a-developmental-etiological-model-for-drug-abuse-in-men
#11
Kenneth S Kendler, Henrik Ohlsson, Alexis C Edwards, Jan Sundquist, Kristina Sundquist
BACKGROUND: We attempt to develop a relatively comprehensive structural model of risk factors for drug abuse (DA) in Swedish men that illustrates developmental and mediational processes. METHODS: We examined 20 risk factors for DA in 48,369 men undergoing conscription examinations in 1969-70 followed until 2011 when 2.34% (n=1134) of them had DA ascertained in medical, criminal and pharmacy registries. Risk factors were organized into four developmental tiers reflecting i) birth, ii) childhood/early adolescence, iii) late adolescence, and iv) young adulthood...
October 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28805240/the-role-of-social-familial-and-individual-level-factors-on-multiple-alcohol-use-outcomes-during-the-first-year-of-university
#12
Megan E Cooke, Zoe E Neale, Peter B Barr, John Myers, Danielle M Dick, Kenneth S Kendler, Alexis C Edwards
BACKGROUND: The first year of university attendance represents a critical time frame for the development of alcohol use and misuse given changes in autonomy and increased access to alcohol. Prior studies have demonstrated that the establishment of drinking patterns during this period is impacted by an array of demographic, environmental, and familial factors. It is critical to consider such factors jointly, and to understand potentially differential effects on stages of alcohol use/misuse, in order to identify robust predictors that may be targeted in prevention and intervention programming...
October 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28760022/thomas-verner-moore
#13
Richard Noll, Colin G DeYoung, Kenneth S Kendler
No abstract text is available yet for this article.
August 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28758771/childhood-trauma-and-distress-tolerance-in-a-trauma-exposed-acute-care-psychiatric-inpatient-sample
#14
Erin C Berenz, Anka A Vujanovic, Lance Rappaport, Salpi Kevorkian, R Emily Gonzalez, Nadia Chowdhury, Christina D Dutcher, Danielle M Dick, Kenneth S Kendler, Ananda B Amstadter
OBJECTIVE: Distress tolerance (DT; the perceived or actual ability to withstand negative internal states) has emerged as a promising transdiagnostic risk factor in clinically severe populations. However, little is known about etiological factors associated with the development of DT. We hypothesized that greater levels of childhood trauma would be associated with lower perceived and behavioral DT, beyond theoretically relevant covariates. METHOD: The current investigation evaluated several childhood trauma types (i...
July 31, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28755782/romosozumab-sclerostin-monoclonal-antibody-versus-teriparatide-in-postmenopausal-women-with-osteoporosis-transitioning-from-oral-bisphosphonate-therapy-a-randomised-open-label-phase-3-trial
#15
Bente L Langdahl, Cesar Libanati, Daria B Crittenden, Michael A Bolognese, Jacques P Brown, Nadia S Daizadeh, Eva Dokoupilova, Klaus Engelke, Joel S Finkelstein, Harry K Genant, Stefan Goemaere, Lars Hyldstrup, Esteban Jodar-Gimeno, Tony M Keaveny, David Kendler, Peter Lakatos, Judy Maddox, Jorge Malouf, Fabio E Massari, Jose Fernando Molina, Maria Rosa Ulla, Andreas Grauer
BACKGROUND: Previous bisphosphonate treatment attenuates the bone-forming effect of teriparatide. We compared the effects of 12 months of romosozumab (AMG 785), a sclerostin monoclonal antibody, versus teriparatide on bone mineral density (BMD) in women with postmenopausal osteoporosis transitioning from bisphosphonate therapy. METHODS: This randomised, phase 3, open-label, active-controlled study was done at 46 sites in North America, Latin America, and Europe...
July 26, 2017: Lancet
https://www.readbyqxmd.com/read/28734091/prediction-of-alcohol-use-disorder-using-personality-disorder-traits-a-twin-study
#16
Tom Rosenström, Fartein Ask Torvik, Eivind Ystrom, Nikolai Olavi Czajkowski, Nathan A Gillespie, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Ted Reichborn-Kjennerud
BACKGROUND AND AIMS: The DSM-IV Personality Disorders (PDs) are comorbid with Alcohol Use Disorder (AUD) and with each other. It remains unclear which PD criteria are most likely to drive onset and recurrence of AUD and which are merely confounded with those criteria. We determine which individual PD criteria predict AUD and the degree of underlying genetic and/or environmental etiology. DESIGN: A prospective observational twin study. SETTING: Norway 1999-2011...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28714599/the-utility-of-empirically-assigning-ancestry-groups-in-cross-population-genetic-studies-of-addiction
#17
Roseann E Peterson, Alexis C Edwards, Silviu-Alin Bacanu, Danielle M Dick, Kenneth S Kendler, Bradley T Webb
BACKGROUND AND OBJECTIVES: Given moderate heritability and significant heterogeneity among addiction phenotypes, successful genome-wide association studies (GWAS) are expected to need very large samples. As sample sizes grow, so can genetic diversity leading to challenges in analyzing these data. Methods for empirically assigning individuals to genetically informed ancestry groups are needed. METHODS: We describe a strategy for empirically assigning ancestry groups in ethnically diverse GWAS data including extensions of principal component analysis (PCA) and population matching through minimum Mahalanobis distance...
August 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28714051/contributions-of-genes-and-environment-to-developmental-change-in-alcohol-use
#18
E C Long, B Verhulst, S H Aggen, K S Kendler, N A Gillespie
The precise nature of how genetic and environmental risk factors influence changes in alcohol use (AU) over time has not yet been investigated. Therefore, the aim of the present study is to examine the nature of longitudinal changes in these risk factors to AU from mid-adolescence through young adulthood. Using a large sample of male twins, we compared five developmental models that each makes different predictions regarding the longitudinal changes in genetic and environmental risks for AU. The best-fitting model indicated that genetic influences were consistent with a gradual growth in the liability to AU, whereas unique environmental risk factors were consistent with an accumulation of risks across time...
July 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28691841/shared-familial-risk-between-bulimic-symptoms-and-alcohol-involvement-during-adolescence
#19
Jessica H Baker, Melissa A Munn-Chernoff, Paul Lichtenstein, Henrik Larsson, Hermine Maes, Kenneth S Kendler
Twin studies show the established relation between bulimic symptoms and problematic alcohol involvement in adult females is partly due to shared familial factors, specifically shared genetic effects. However, it is unclear if similar shared etiological factors exist during adolescence or in males. We examined the familial overlap (i.e., genetic and common environmental correlations) between bulimic symptoms and various levels of alcohol involvement in 16- to 17-year-old female and male same-sex twin pairs using sex-specific biometrical twin modeling...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28666429/common-adult-psychiatric-disorders-in-swedish-primary-care-where-most-mental-health-patients-are-treated
#20
Jan Sundquist, Henrik Ohlsson, Kristina Sundquist, Kenneth S Kendler
BACKGROUND: The overall aim of this study is to present descriptive data regarding the treated prevalence of nine common psychiatric and substance use disorders in the first Primary Care Registry (PCR) in Sweden: Major Depression (MD), Anxiety Disorders (AD), Obsessive-Compulsive Disorder (OCD), Adjustment Disorder (AdjD), Eating Disorders (ED), Personality Disorder (PD), Attention Deficit Hyperactivity Disorder (ADHD), Alcohol Use Disorder (AUD) and Drug Abuse (DA). METHOD: We selected 5,397,675 individuals aged ≥18...
June 30, 2017: BMC Psychiatry
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