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https://www.readbyqxmd.com/read/29672714/effects-of-long-term-denosumab-on-bone-histomorphometry-and-mineralization-in-women-with-postmenopausal-osteoporosis
#1
David W Dempster, Jacques P Brown, Astrid Fahrleitner-Pammer, David Kendler, Sebastien Rizzo, Ivo Valter, Rachel B Wagman, Xiang Yin, Susan V Yue, Georges Boivin
Context: Denosumab is a potent antiresorptive agent that reduces fractures in postmenopausal women with osteoporosis. Objective: Determine effects of up to 10 years of denosumab on bone histology, bone remodeling, and bone matrix mineralization characteristics. Design and Setting: International, multicenter, randomized, double-blind trial (FREEDOM) with a long-term open-label extension (Extension). Patients: Postmenopausal women with osteoporosis (92 women in FREEDOM, 46 in Extension) who provided iliac bone biopsies, including 11 who provided biopsies at multiple time points...
April 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29667198/alcohol-availability-and-onset-and-recurrence-of-alcohol-use-disorder-examination-in-a-longitudinal-cohort-with-co-sibling-analysis
#2
Katherine J Karriker-Jaffe, Henrik Ohlsson, Kenneth S Kendler, Won Kim Cook, Kristina Sundquist
BACKGROUND: Recent reviews of associations of alcohol availability with alcohol outcomes suggest findings are highly inconsistent and highlight a lack of longitudinal and causal evidence. Effect modification (moderation or statistical interaction), which could contribute to the inconsistent picture in the existing literature, has not been systematically assessed. We examined associations of alcohol availability with onset and recurrence of alcohol use disorder (AUD) using multi-level, longitudinal population data from Sweden and test hypothesized effect modifiers to identify groups for whom increased alcohol availability may be particularly risky...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29652647/prevalence-and-predictors-of-ptsd-among-a-college-sample
#3
Shannon E C Usack, Terrell A Hicks, Jessica Bourdon, Christina M Sheerin, Cassie M Overstreet, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: This study examined the prevalence and correlates of probable posttraumatic stress disorder (PTSD) in freshman entering college and prospective associations of probable PTSD with additional outcomes. PARTICIPANTS: 2,310 students with data collected from Fall 2014 through Spring 2015. METHODS: Incoming freshman completed a survey assessing for relevant variables at the beginning of fall semester and during the spring semester. RESULTS: Seventy percent of the sample endorsed experiencing at least one potentially traumatic event (PTE)...
April 13, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29558815/a-twin-study-of-normative-personality-and-dsm-iv-personality-disorder-criterion-counts-evidence-for-separate-genetic-influences
#4
Nikolai Czajkowski, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Michael C Neale, Gun Peggy Knudsen, Nathan A Gillespie, Espen Røysamb, Kristian Tambs, Ted Reichborn-Kjennerud
OBJECTIVE: Both normative personality and DSM-IV personality disorders have been found to be heritable. However, there is limited knowledge about the extent to which the genetic and environmental influences underlying DSM personality disorders are shared with those of normative personality. The aims of this study were to assess the phenotypic similarity between normative and pathological personality and to investigate the extent to which genetic and environmental influences underlying individual differences in normative personality account for symptom variance across DSM-IV personality disorders...
March 21, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29554991/historical-precedents-for-the-dsm-iii-bereavement-exclusion-criteria-for-major-depression
#5
Kenneth S Kendler
BACKGROUND: I review the historical antecedents of the two key features of the bereavement exclusion (BE) for major depression (MD) criteria initially proposed in DSM-III: (i) a context-dependent approach to the evaluation of MD which required that the diagnosis be given only when course, symptoms and signs are 'out of proportion' to experienced adversities, and (ii) bereavement is the sole adversity for which this context-dependent approach should be utilized. METHODS: A review of 49 textbook and review articles on depression or melancholia published 1880-1960...
March 20, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29540840/correction-to-psychiatric-genetics-and-the-structure-of-psychopathology
#6
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
In the Table 1 legend, the reference numbers and symbols were not correctly presented in the footnotes. The corrected footnotes are presented below.
March 14, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29530109/the-nature-of-nurture-using-a-virtual-parent-design-to-test-parenting-effects-on-children-s-educational-attainment-in-genotyped-families
#7
Timothy C Bates, Brion S Maher, Sarah E Medland, Kerrie McAloney, Margaret J Wright, Narelle K Hansell, Kenneth S Kendler, Nicholas G Martin, Nathan A Gillespie
Research on environmental and genetic pathways to complex traits such as educational attainment (EA) is confounded by uncertainty over whether correlations reflect effects of transmitted parental genes, causal family environments, or some, possibly interactive, mixture of both. Thus, an aggregate of thousands of alleles associated with EA (a polygenic risk score; PRS) may tap parental behaviors and home environments promoting EA in the offspring. New methods for unpicking and determining these causal pathways are required...
March 13, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29507643/terahertz-spectroscopy-of-2-4-6-trinitrotoluene-molecular-solids-from-first-principles
#8
Ido Azuri, Anna Hirsch, Anthony M Reilly, Alexandre Tkatchenko, Shai Kendler, Oded Hod, Leeor Kronik
We present a computational analysis of the terahertz spectra of the monoclinic and the orthorhombic polymorphs of 2,4,6-trinitrotoluene. Very good agreement with experimental data is found when using density functional theory that includes Tkatchenko-Scheffler pair-wise dispersion interactions. Furthermore, we show that for these polymorphs the theoretical results are only weakly affected by many-body dispersion contributions. The absence of dispersion interactions, however, causes sizable shifts in vibrational frequencies and directly affects the spatial character of the vibrational modes...
2018: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29505386/relationships-among-avoidant-personality-disorder-social-anxiety-disorder-and-normative-personality-traits-a-twin-study
#9
Audun Welander-Vatn, Fartein Ask Torvik, Nikolai Czajkowski, Kenneth S Kendler, Ted Reichborn-Kjennerud, Gun Peggy Knudsen, Eivind Ystrom
Avoidant personality disorder (AvPD) and social anxiety disorder (SAD) share risk factors to a substantial degree, and both are characterized by the experience of anxiety in social situations. The authors investigated whether these disorders are differentially related to the Big Five personality traits. They also examined the underlying genetic and environmental influences on these associations. A population-based sample of 1,761 female twins was interviewed at baseline, and 1,471 of these were re-interviewed 10 years later...
March 5, 2018: Journal of Personality Disorders
https://www.readbyqxmd.com/read/29500852/associations-between-personality-disorders-and-cannabis-use-and-cannabis-use-disorder-a-population-based-twin-study
#10
N A Gillespie, S H Aggen, M C Neale, G P Knudsen, R F Krueger, S C South, N Czajkowski, R Nesvåg, E Ystrom, K S Kendler, T Reichborn-Kjennerud
BACKGROUND AND AIMS: Individual differences in DSM-IV personality disorders (PDs) are associated with increased prevalence of substance use disorders. Our aims were to determine which combination of PDs trait scores best predict cannabis use (CU) and cannabis use disorder (CUD), and to estimate the size and significance of genetic and environmental risks in PD traits shared with CU and CUD. DESIGN: Linear mixed effects models were used to identify PD traits for inclusion in twin analyses to explore the genetic and environmental associations between the traits and cannabis use...
March 3, 2018: Addiction
https://www.readbyqxmd.com/read/29495898/molecular-genetic-analysis-subdivided-by-adversity-exposure-suggests-etiologic-heterogeneity-in-major-depression
#11
Roseann E Peterson, Na Cai, Andy W Dahl, Tim B Bigdeli, Alexis C Edwards, Bradley T Webb, Silviu-Alin Bacanu, Noah Zaitlen, Jonathan Flint, Kenneth S Kendler
OBJECTIVE: The extent to which major depression is the outcome of a single biological mechanism or represents a final common pathway of multiple disease processes remains uncertain. Genetic approaches can potentially identify etiologic heterogeneity in major depression by classifying patients on the basis of their experience of major adverse events. METHOD: Data are from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology (CONVERGE) project, a study of Han Chinese women with recurrent major depression aimed at identifying genetic risk factors for major depression in a rigorously ascertained cohort carefully assessed for key environmental risk factors (N=9,599)...
March 2, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29417130/the-origin-of-spousal-resemblance-for-alcohol-use-disorder
#12
Kenneth S Kendler, Sara Larsson Lönn, Jessica Salvatore, Jan Sundquist, Kristina Sundquist
Importance: Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives: To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner and to explore changes in the risk for AUD registration in individuals with multiple marriages as they transition from a spouse with AUD to one without or vice versa...
February 7, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29405876/effects-of-social-support-on-the-association-between-pre-college-sexual-assault-and-college-onset-victimization
#13
Sage E Hawn, Mackenzie J Lind, Abigail Conley, Cassie M Overstreet, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: This study examined the moderating and mediating effects of perceived social support on the association between pre-college sexual assault (SA) and college-onset SA. PARTICIPANTS: A representative sample of 6,132 undergraduates. METHODS: The PLUM procedure in SPSS was used to test the moderation model, with individual regressions conducted in a hierarchical fashion. A weighted least squared mean and variance adjusted (WLSMV) mediation model was used to examine the mediating effect of social support...
February 6, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29405378/polygenic-risk-score-prediction-of-alcohol-dependence-symptoms-across-population-based-and-clinically-ascertained-samples
#14
Jeanne E Savage, Jessica E Salvatore, Fazil Aliev, Alexis C Edwards, Matthew Hickman, Kenneth S Kendler, John Macleod, Antti Latvala, Anu Loukola, Jaakko Kaprio, Richard J Rose, Grace Chan, Victor Hesselbrock, Bradley T Webb, Amy Adkins, Tim B Bigdeli, Brien P Riley, Danielle M Dick
BACKGROUND: Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations. The aim of this study was thus to evaluate whether aggregate genetic risk for AUDs differed between clinically ascertained and population-based epidemiological samples. METHODS: Four independent samples were obtained: 2 from unselected birth cohorts (Avon Longitudinal Study of Parents and Children [ALSPAC], N = 4,304; FinnTwin12 [FT12], N = 1,135) and 2 from families densely affected with AUDs, identified from treatment-seeking patients (Collaborative Study on the Genetics of Alcoholism, N = 2,097; Irish Affected Sib Pair Study of Alcohol Dependence, N = 706)...
February 5, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29369040/testing-genetic-and-environmental-associations-between-personality-disorders-and-cocaine-use-a-population-based-twin-study
#15
Nathan A Gillespie, Steven H Aggen, Amanda E Gentry, Michael C Neale, Gun P Knudsen, Robert F Krueger, Susan C South, Nikolai Czajkowski, Ragnar Nesvåg, Eivind Ystrom, Tom H Rosenström, Fartein A Torvik, Ted Reichborn-Kjennerud, Kenneth S Kendler
Until now, data have not been available to elucidate the genetic and environmental sources of comorbidity between all 10 DSM-IV personality disorders (PDs) and cocaine use. Our aim was to determine which PD traits are linked phenotypically and genetically to cocaine use. Cross-sectional data were obtained in a face-to-face interview between 1999 and 2004. Subjects were 1,419 twins (µage = 28.2 years, range = 19-36) from the Norwegian Institute of Public Health Twin Panel, with complete lifetime cocaine use and criteria for all 10 DSM-IV PDs...
February 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29346036/genetics-the-rearing-environment-and-the-intergenerational-transmission-of-divorce-a-swedish-national-adoption-study
#16
Jessica E Salvatore, Sara Larsson Lönn, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler
We used classical and extended adoption designs in Swedish registries to disentangle genetic and rearing-environment influences on the intergenerational transmission of divorce. In classical adoption analyses, adoptees ( n = 19,715) resembled their biological parents, rather than their adoptive parents, in their history of divorce. In extended adoption analyses, offspring ( n = 82,698) resembled their not-lived-with fathers and their lived-with mothers. There was stronger resemblance to lived-with mothers, providing indirect evidence of rearing-environment influences on the intergenerational transmission of divorce...
March 2018: Psychological Science
https://www.readbyqxmd.com/read/29334617/chains-of-risk-for-alcohol-use-disorder-mediators-of-exposure-to-neighborhood-deprivation-in-early-and-middle-childhood
#17
Katherine J Karriker-Jaffe, Sara L Lönn, Won K Cook, Kenneth S Kendler, Kristina Sundquist
Our goal was to test a cascade model to identify developmental pathways, or chains of risk, from neighborhood deprivation in childhood to alcohol use disorder (AUD) in young adulthood. Using Swedish general population data, we examined whether exposure to neighborhood deprivation during early and middle childhood was associated with indicators of social functioning in adolescence and emerging adulthood, and whether these were predictive of AUD. Structural equation models showed exposure to neighborhood deprivation was associated with lower school achievement during adolescence, poor social functioning during emerging adulthood, and the development of AUD for both males and females...
March 2018: Health & Place
https://www.readbyqxmd.com/read/29329484/effects-of-teriparatide-compared-with-risedronate-on-the-risk-of-fractures-in-subgroups-of-postmenopausal-women-with-severe-osteoporosis-the-vero-trial
#18
Piet Geusens, Fernando Marin, David L Kendler, Luis A Russo, Cristiano Af Zerbini, Salvatore Minisola, Jean Jacques Body, Eric Lespessailles, Susan L Greenspan, Alicia Bagur, Jan J Stepan, Péter Lakatos, Enrique Casado, Rüdiger Moericke, Pedro López-Romero, Astrid Fahrleitner-Pammer
The 2-year, randomized, double-blind, active-controlled fracture endpoint VERO study included postmenopausal women with established osteoporosis, who had at least 2 moderate or 1 severe baseline vertebral fractures (VFx), and bone mineral density (BMD) T-score ≤-1.5. Patients were treated with either s.c. daily teriparatide 20 μg or oral weekly risedronate 35 mg. As previously reported, the risk of new VFx and clinical fractures (a composite of clinical VFx and nonvertebral fragility fractures [NVFFx]) was statistically significantly reduced with teriparatide compared with risedronate...
January 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29317742/psychiatric-genetics-and-the-structure-of-psychopathology
#19
REVIEW
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
For over a century, psychiatric disorders have been defined by expert opinion and clinical observation. The modern DSM has relied on a consensus of experts to define categorical syndromes based on clusters of symptoms and signs, and, to some extent, external validators, such as longitudinal course and response to treatment. In the absence of an established etiology, psychiatry has struggled to validate these descriptive syndromes, and to define the boundaries between disorders and between normal and pathologic variation...
January 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29284197/the-associations-between-psychotic-experiences-and-substance-use-and-substance-use-disorders-findings-from-the-world-health-organization-world-mental-health-surveys
#20
Louisa Degenhardt, Sukanta Saha, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Jordi Alonso, Laura H Andrade, Evelyn J Bromet, Ronny Bruffaerts, José Miguel Caldas-de-Almeida, Giovanni de Girolamo, Silvia Florescu, Oye Gureje, Josep M Haro, Elie G Karam, Georges Karam, Viviane Kovess-Masfety, Sing Lee, Jean-Pierre Lepine, Victor Makanjuola, Maria E Medina-Mora, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, José Posada-Villa, Nancy A Sampson, Kate M Scott, Juan Carlos Stagnaro, Margreet Ten Have, Kenneth S Kendler, Ronald C Kessler, John J McGrath
BACKGROUND AND AIMS: Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We used data from the World Health Organization World Mental Health surveys...
December 28, 2017: Addiction
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