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https://www.readbyqxmd.com/read/28547916/non-shivering-thermogenesis-as-a-mechanism-to-facilitate-sustainable-weight-loss
#1
REVIEW
B F Palmer, D J Clegg
Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate sustainable weight loss. Reductions in basal metabolic rate occur in the face of weight loss and pose formidable barriers to individuals attempting to sustain meaningful weight reductions. Here, we discuss the mechanisms by which non-shivering thermogenesis may provide insight into metabolic pathways that can become druggable targets to facilitate sustainable weight loss...
May 25, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28546591/the-healthcare-system-and-the-provision-of-oral-healthcare-in-european-union-member-states-part-8-italy
#2
M Bindi, C Paganelli, K A Eaton, E Widström
In Italy healthcare is provided for all Italian citizens and residents and it is delivered mainly by public providers, with some private or private-public entities. Italy's public healthcare system - the Servizio Sanitario Nazionale (SSN) - is organised by the Ministry of Health and administered on a devolved regional basis. It is financed by general taxation that provides universal coverage, largely free of charge at the point of service. The central government establishes the basic national health benefits package, which must be uniformly provided throughout the country, through services guaranteed under the NHS provision called LEA - (Livelli Essenziali di Assistenza [Essential Level of Assistance]) and allocates national funds to the regions...
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28545532/cytotoxicity-of-the-methanol-extracts-of-elephantopus-mollis-kalanchoe-crenata-and-4-other-cameroonian-medicinal-plants-towards-human-carcinoma-cells
#3
Victor Kuete, Fabrice W Fokou, Oğuzhan Karaosmanoğlu, Veronique P Beng, Hülya Sivas
BACKGROUND: Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system. METHODS: In this study, the cytotoxicity of the methanol extract of Elephantopus mollis whole plant (EMW), Enantia chlorantha bark (ECB), Kalanchoe crenata leaves (KCL), Lophira alata bark (LAB), Millettia macrophylla leaves (MML) and Phragmanthera capitata leaves (PCL) towards five human solid cancer cell lines and normal CRL2120 fibroblasts, was evaluated...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28545433/developing-a-comprehensive-measure-of-mobility-mobility-over-varied-environments-scale-moves
#4
Jana A Hirsch, Meghan Winters, Joanie Sims-Gould, Philippa J Clarke, Nathalie Ste-Marie, Maureen Ashe, Heather A McKay
BACKGROUND: While recent work emphasizes the multi-dimensionality of mobility, no current measure incorporates multiple domains of mobility. Using existing conceptual frameworks we identified four domains of mobility (physical, cognitive, social, transportation) to create a "Mobility Over Varied Environments Scale" (MOVES). We then assessed expected patterns of MOVES in the Canadian population. METHODS: An expert panel identified survey items within each MOVES domain from the Canadian Community Health Survey- Healthy Aging Cycle (2008-2009) for 28,555 (weighted population n = 12,805,067) adults (≥45 years)...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28545332/a-nationwide-uk-survey-of-female-fertility-preservation-prior-to-cancer-treatment
#5
Yazan Abdallah, Jonathan Briggs, Joshua Jones, Gregory Horne, Cheryl Fitzgerald
This survey examined the provision of fertility preservation for female oncology patients prior to cancer treatments, given their well-established gonadotoxic effects. Questionnaires were sent to all assisted conception units in the UK enquiring about the provision of oocyte or embryo cryopreservation, as well as funding for female oncology patients. In addition, data were obtained from the Human Fertilisation and Embryology Authority (HFEA) on the number of cryopreservation cycles in 2013-2014. Of the 60 responding units, 53 (88%) offered fertility preservation...
May 26, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28545193/synthesis-characterization-and-cytotoxic-evaluation-of-graphene-oxide-nanosheets-in-vitro-liver-cancer-model
#6
Samah A Loutfy, Taher A Salaheldin, Marwa A Ramadan, Khaled Yehia Farroh, Zeinab F Abdallah, Tareq Youssef
Background: Graphene nanosheets have a broad spectrum of biomedical applications. Hepatocellular cancer (HCC) is a major health problem in the Egyptian population. Currently, treatment strategies are invasive and have several adverse side effects. Thus, other approaches are required for managing this aggressive type of cancer. Our objective here was to prepare and characterize graphene oxide nanosheets and evaluate cytotoxic effect at the molecular level in an in vitro human liver cancer cell model (HepG2)...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544996/temperate-bacteriophages-as-regulators-of-host-behavior
#7
REVIEW
Tal Argov, Gil Azulay, Anna Pasechnek, Olga Stadnyuk, Shai Ran-Sapir, Ilya Borovok, Nadejda Sigal, Anat A Herskovits
Bacteriophages are ubiquitous and affect most facets of life, from evolution of bacteria, through ecology and global biochemical cycling to human health. The interactions between phages and bacteria often lead to biological novelty and an important milestone in this process is the ability of phages to regulate their host's behavior. In this review article, we will focus on newly reported cases that demonstrate how temperate phages regulate bacterial gene expression and behavior in a variety of bacterial species, pathogenic and environmental...
May 22, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28543214/the-forecasting-of-menstruation-based-on-a-state-space-modeling-of-basal-body-temperature-time-series
#8
Keiichi Fukaya, Ai Kawamori, Yutaka Osada, Masumi Kitazawa, Makio Ishiguro
Women's basal body temperature (BBT) shows a periodic pattern that associates with menstrual cycle. Although this fact suggests a possibility that daily BBT time series can be useful for estimating the underlying phase state as well as for predicting the length of current menstrual cycle, little attention has been paid to model BBT time series. In this study, we propose a state-space model that involves the menstrual phase as a latent state variable to explain the daily fluctuation of BBT and the menstruation cycle length...
May 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28542630/dose-dependent-effect-of-silver-nanoparticles-agnps-on-fertility-and-survival-of-drosophila-an-in-vivo-study
#9
Akanksha Raj, Prasanna Shah, Namita Agrawal
Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28542609/potent-and-selective-inhibition-of-pathogenic-viruses-by-engineered-ubiquitin-variants
#10
Wei Zhang, Ben A Bailey-Elkin, Robert C M Knaap, Baldeep Khare, Tim J Dalebout, Garrett G Johnson, Puck B van Kasteren, Nigel J McLeish, Jun Gu, Wenguang He, Marjolein Kikkert, Brian L Mark, Sachdev S Sidhu
The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Congo hemorrhagic fever virus (CCHFV) encode deubiquitinating (DUB) enzymes that are critical for viral replication and pathogenicity. They bind and remove ubiquitin (Ub) and interferon stimulated gene 15 (ISG15) from cellular proteins to suppress host antiviral innate immune responses...
May 18, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28541816/influences-of-socio-demographic-factors-and-health-utilization-factors-on-patient-centered-provider-communication
#11
Shipra Singh, Na'Tasha Evans, Monica Williams, Nilgun Sezginis, Nana Ama Kwarteng Baryeh
Patient-centered care has been documented as a measure of quality of health care and has been associated with positive health outcomes. However, the effect of health utilization on improving patient-centered communication has not been investigated. This study examined the effect of three important kinds of health utilization: routine check-up, frequency of provider visits in the last year, and quality of health care to patient-centered provider communication. Cross-sectional data from 3,608 respondents to Health Information National Trends Survey-Cycle 4 2014 were analyzed...
May 25, 2017: Health Communication
https://www.readbyqxmd.com/read/28541651/channel-crack-designed-gold-pu-sponge-for-highly-elastic-piezoresistive-sensor-with-excellent-detectability
#12
Yun-Hui Wu, Hai-Zhou Liu, Song Chen, Xuchu Dong, Ping-Ping Wang, Shuqi Liu, Yong Lin, Yong Wei, Lan Liu
It is a great challenge to fabricate piezoresistive sensors that possess high elasticity, large-area compliance and excellent detectability to satisfy both extremely tiny and large human activities monitoring. Herein, a novel and facile strategy is reported to manufacture highly elastic channel crack-based gold@PU sponge piezoresistive material. The elastic 3D conductive network is successfully prepared by gold ion sputtering, and channel cracks are skillfully designed on the 3D sponge skeletons. Such novel structure makes these fabricated sensors are capable of monitoring both tiny and large human motions, which originate from the nano-crack joint sensing mechanism and physical contact of conductive interconnected network...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541359/potential-antiproliferative-activity-of-polyphenol-metabolites-against-human-breast-cancer-cells-and-their-urine-excretion-pattern-in-healthy-subjects-following-acute-intake-of-a-polyphenol-rich-juice-of-grumixama-eugenia-brasiliensis-lam
#13
L L Teixeira, G R Costa, F A Dörr, T P Ong, E Pinto, F M Lajolo, N M A Hassimotto
The bioavailability and metabolism of anthocyanins and ellagitannins following acute intake of grumixama fruit, native Brazilian cherry, by humans, and its in vitro antiproliferative activity against breast cancer cells (MDA-MB-231) were investigated. A single dose of grumixama juice was administered to healthy women (n = 10) and polyphenol metabolites were analyzed in urine and plasma samples collected over 24 h. The majority of the metabolites circulating and excreted in urine were phenolic acids and urolithin conjugates, the gut microbiota catabolites of both classes of polyphenols, respectively...
May 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28540487/importance-of-common-wall-lizards-in-the-transmission-dynamics-of-tick-borne-pathogens-in-the-northern-apennine-mountains-italy
#14
Laura Tomassone, L A Ceballos, C Ragagli, E Martello, R De Sousa, M C Stella, A Mannelli
During the investigations on ticks and tick-borne pathogens (TBP) range expansion in the Northern Apennines, we captured 107 Podarcis muralis lizards. Sixty-eight animals were infested by immature Ixodes ricinus, Haemaphysalis sulcata and H. punctata. Borrelia burgdorferi s.l. was detected in 3.7% of I. ricinus larvae and 8.0% of nymphs. Together with the species-specific B. lusitaniae, we identified B. garinii, B. afzelii and B. valaisiana. Rickettsia spp. (18.1% larvae, 12.0% nymphs), namely R. monacensis, R...
May 24, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28539216/cost-effectiveness-of-using-recombinant-human-thyroid-stimulating-hormone-before-radioiodine-ablation-for-thyroid-cancer-treatment-in-spanish-hospitals
#15
J A Vallejo, M A Muros
OBJECTIVES: In thyroid cancer treatment, the thyroid-stimulating hormone (TSH) must be elevated before radioiodine ablation, either by exogenous (with recombinant human thyrotropin [rhTSH]) or endogenous stimulation by thyroid hormone withdrawal (THW). The use of rhTSH avoids hypothyroidism and favours the subsequent elimination of radioiodine, but involves the cost of the product. For this reason, a cost-effectiveness analysis was performed, taking into account all costs involved and the benefits associated with the use of this therapy...
May 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28538934/availability-of-herbal-medicines-and-medicinal-plants-in-the-primary-health-facilities-of-the-state-of-s%C3%A3-o-paulo-southeast-brazil-results-from-the-national-program-for-access-and-quality-improvement-in-primary-care
#16
Maria do Carmo Gullaci Guimarães Caccia-Bava, Bianca Waléria Bertoni, Ana Maria Soares Pereira, Edson Zangiacomi Martinez
This study aims to describe the availability of herbal medicines and medicinal plants in the primary care facilities in the state of São Paulo, Southeast Brazil, from the results of the first cycle of the National Program for Access and Quality Improvement in Primary Care (PMAQ). The PMAQ uses a national cross-sectional multicenter design, with data from 4,249 health facilities distributed among 645 municipalities of the state of São Paulo. Of these facilities, 467 (11%) had herbal medicines and/or medicinal plants...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538708/accuracy-in-wrist-worn-sensor-based-measurements-of-heart-rate-and-energy-expenditure-in-a-diverse-cohort
#17
Anna Shcherbina, C Mikael Mattsson, Daryl Waggott, Heidi Salisbury, Jeffrey W Christle, Trevor Hastie, Matthew T Wheeler, Euan A Ashley
The ability to measure physical activity through wrist-worn devices provides an opportunity for cardiovascular medicine. However, the accuracy of commercial devices is largely unknown. The aim of this work is to assess the accuracy of seven commercially available wrist-worn devices in estimating heart rate (HR) and energy expenditure (EE) and to propose a wearable sensor evaluation framework. We evaluated the Apple Watch, Basis Peak, Fitbit Surge, Microsoft Band, Mio Alpha 2, PulseOn, and Samsung Gear S2. Participants wore devices while being simultaneously assessed with continuous telemetry and indirect calorimetry while sitting, walking, running, and cycling...
May 24, 2017: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/28538691/the-potential-cost-effectiveness-of-pre-exposure-prophylaxis-combined-with-hiv-vaccines-in-the-united-states
#18
Blythe J S Adamson, Josh J Carlson, James G Kublin, Louis P Garrison
This economic evaluation aims to support policy-making on the combined use of pre-exposure prophylaxis (PrEP) with HIV vaccines in development by evaluating the potential cost-effectiveness of implementation that would support the design of clinical trials for the assessment of combined product safety and efficacy. The target study population is a cohort of men who have sex with men (MSM) in the United States. Policy strategies considered include standard HIV prevention, daily oral PrEP, HIV vaccine, and their combination...
May 24, 2017: Vaccines
https://www.readbyqxmd.com/read/28538496/committee-opinion-no-702-female-athlete-triad
#19
(no author information available yet)
The female athlete triad is a medical condition observed in physically active females involving three components: 1) low energy availability with or without disordered eating, 2) menstrual dysfunction, and 3) low bone density. An individual does not need to show clinical manifestations of all three components of the female athlete triad simultaneously to be affected by the condition. Consequences of these clinical conditions may not be completely reversible, so prevention, early diagnosis, and intervention are critical...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28538492/committee-opinion-no-702-summary-female-athlete-triad
#20
(no author information available yet)
The female athlete triad is a medical condition observed in physically active females involving three components: 1) low energy availability with or without disordered eating, 2) menstrual dysfunction, and 3) low bone density. An individual does not need to show clinical manifestations of all three components of the female athlete triad simultaneously to be affected by the condition. Consequences of these clinical conditions may not be completely reversible, so prevention, early diagnosis, and intervention are critical...
June 2017: Obstetrics and Gynecology
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