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https://www.readbyqxmd.com/read/28938248/a-youth-compendium-of-physical-activities-activity-codes-and-metabolic-intensities
#1
Nancy F Butte, Kathleen B Watson, Kate Ridley, Issa F Zakeri, Robert G McMurray, Karin A Pfeiffer, Scott E Crouter, Stephen D Herrmann, David R Bassett, Alexander Long, Zekarias Berhane, Stewart G Trost, Barbara E Ainsworth, David Berrigan, Janet E Fulton
PURPOSE: A Youth Compendium of Physical Activities (Youth Compendium) was developed to estimate the energy costs of physical activities using data on youth only. METHODS: Based on a literature search and pooled data of energy expenditure measurements in youth, the energy costs of 196 activities were compiled in 16 activity categories to form a Youth Compendium of Physical Activities. To estimate the intensity of each activity, measured oxygen consumption (V[Combining Dot Above]O2) was divided by basal metabolic rate (Schofield age-, sex- and mass-specific equations) to produce a youth MET (METy)...
September 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28938080/dr-polio-revisiting-fdr-s-medical-legacy
#2
Robert G Dorfman, Asher Orkaby, Sukumar P Desai
The National Foundation for Infantile Paralysis (NFIP), the March of Dimes, and the Georgia Warm Springs Resort were reflections of Franklin D. Roosevelt's (FDR) complicated and personal relationship with polio. Between 1934 and 1957, significant advances were made in the care of polio survivors, and new and innovative medical fields gained both public attention and funding. The plight of disabled Americans and questions of accessibility also received widespread national attention. The NFIP helped establish a new prototype for grassroots philanthropy and personified FDR's vision for national health insurance...
September 22, 2017: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/28938075/the-human-plasma-proteome-draft-of-2017-building-on-the-human-plasma-peptideatlas-from-mass-spectrometry-and-complementary-assays
#3
Jochen M Schwenk, Gilbert S Omenn, Zhi Sun, David S Campbell, Mark S Baker, Christopher M Overall, Ruedi Aebersold, Robert L Moritz, Eric W Deutsch
Human blood plasma provides a highly accessible window to the proteome of any individual in health and disease. Since its inception in 2002, the Human Proteome Organization's Human Plasma Proteome Project (HPPP) has been promoting advances in the study and understanding of the full protein complement of human plasma and on determining the abundance and modifications of its components. In 2017, we review the history of the HPPP and the advances of human plasma proteomics in general, including several recent achievements...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28937273/cone-beam-ct-acquisition-during-transradial-tace-made-easy-use-of-the-swivel-arm-board
#4
Uei Pua, Chia Chia Teo, Pe Thet U, Lawrence Han Hwee Quek
OBJECTIVE: Transradial access for peripheral intervention often requires certain modification from its coronary counterparts. One of the challenges during transradial transarterial chemoembolization (TACE) is the need for the access arm to be repositioned during cone-beam CT (CBCT) acquisition to allow for C-arm rotation. We recently introduced a swivel arm board to allow seamless repositioning of the access arm during and after CBCT acquisition. The purpose of this study is to detail the technique and feasibility of this useful adjunct to transradial TACE...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936272/hereditary-gynaecologic-cancers-in-nepal-a-proposed-model-of-care-to-serve-high-risk-populations-in-developing-countries
#5
Hanoon P Pokharel, Neville F Hacker, Lesley Andrews
BACKGROUND: Endometrial, ovarian and breast cancers are paradigms for global health disparity. Women living in the developing world continue to present in later stages of disease and have fewer options for treatment than those in developed countries. Risk reducing surgery is of proven benefit for women at high risk of gynaecological cancer. There is no specific model for identification and management of such women in the developing world. METHODS: We have integrated data from our published audit of a major gynaecological oncology centre at Royal Hospital for Women in Australia, with data from our survey and a focus group discussion of Nepalese gynaecological health care professionals regarding genetic testing, and findings from the literature...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28935617/the-adverse-drug-reactions-from-patient-reports-in-social-media-project-five-major-challenges-to-overcome-to-operationalize-analysis-and-efficiently-support-pharmacovigilance-process
#6
Cedric Bousquet, Badisse Dahamna, Sylvie Guillemin-Lanne, Stefan J Darmoni, Carole Faviez, Charles Huot, Sandrine Katsahian, Vincent Leroux, Suzanne Pereira, Christophe Richard, Stéphane Schück, Julien Souvignet, Agnès Lillo-Le Louët, Nathalie Texier
BACKGROUND: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Classical Pharmacovigilance process is limited by underreporting which justifies the current interest in new knowledge sources such as social media. The Adverse Drug Reactions from Patient Reports in Social Media (ADR-PRISM) project aims to extract ADRs reported by patients in these media. We identified 5 major challenges to overcome to operationalize the analysis of patient posts: (1) variable quality of information on social media, (2) guarantee of data privacy, (3) response to pharmacovigilance expert expectations, (4) identification of relevant information within Web pages, and (5) robust and evolutive architecture...
September 21, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28932904/a-computational-method-using-the-random-walk-with-restart-algorithm-for-identifying-novel-epigenetic-factors
#7
JiaRui Li, Lei Chen, ShaoPeng Wang, YuHang Zhang, XiangYin Kong, Tao Huang, Yu-Dong Cai
Epigenetic regulation has long been recognized as a significant factor in various biological processes, such as development, transcriptional regulation, spermatogenesis, and chromosome stabilization. Epigenetic alterations lead to many human diseases, including cancer, depression, autism, and immune system defects. Although efforts have been made to identify epigenetic regulators, it remains a challenge to systematically uncover all the components of the epigenetic regulation in the genome level using experimental approaches...
September 20, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28932652/psychosocial-treatment-options-for-major-depressive-disorder-in-older-adults
#8
Brenna N Renn, Patricia A Areán
Late-life depression (LLD) is a public health concern with deleterious effects on overall health, cognition, quality of life, and mortality. Although LLD is relatively common, it is not a normal part of aging and is often under-recognized in older adults. However, psychotherapy is an effective treatment for LLD that aligns with many patients' preferences and can improve health and functioning. This review synthesized the current literature on evidence-based psychotherapies for the treatment of depression in older adults...
March 2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/28930886/upper-eyelid-splitting-to-facilitate-the-insertion-of-glaucoma-drainage-devices
#9
Lorraine M Provencher, Keith D Carter, Jeffrey A Nerad, Wallace L M Alward
PURPOSE: To describe a new application for vertical splitting of the upper eyelid, a technique traditionally used for orbital access, in order to facilitate glaucoma drainage device implantation in patients with poor surgical exposure. METHODS: Case series. CASES: We present a case of Möbius syndrome with complete restriction of the extraocular muscles, followed by a case of cicatricial narrowing of the palpebral fissures due to chronic allergic dermatitis...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28930783/retrospective-analysis-of-the-effect-of-hering-law-on-outcomes-of-surgical-correction-of-ptosis
#10
Er Pan, Jiangang Yu, Shengchang Zhang, Yunfei Nie, Qin Li
INTRODUCTION: Several factors may influence aesthetic outcomes of ptosis surgery, especially in patients with asymmetrical ptosis. We retrospectively assessed the effect of Hering law on surgical outcomes of patients with asymmetrical ptosis. METHODS: Patients with mild to moderate asymmetrical ptosis (N = 300) who underwent advancement or plication of upper eyelid aponeurosis between January 2014 and July 2016 were enrolled. Fifty patients (group A) underwent surgery without taking into consideration the impact of Hering law...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28930611/biomass-breakdown-a-review-on-pretreatment-instrumentations-and-methods
#11
Preeti Vyas, Ashwani Kumar, Suren Singh
Enzymatic breakdown of lignocellulosic biomass for liquid fuel production is a viable alternative to fossil fuels, due to its renewable and environmental friendly nature. Naturally, plants protect their cell wall polysaccharides by giving limited access to the cell wall degrading enzymes. Lignocellulose breakdown requires proper pretreatments that disrupt the close inter-component association between the constituents of the plant cell wall. For efficient biomass conversion, the choice of the correct pretreatment is important for removing the barriers to enhance access to microbial enzymes...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930519/divergent-impact-of-gender-in-advancement-of-liver-injuries-diseases-and-carcinogenesis
#12
Subhrajit Biswas, Sampa Ghose
Several investigations have revealed that liver diseases exhibit gender biases, but identifying the root causes of such biases has been challenging. Evidence of gender differences in liver function is present from the early stage of embryonic development. The differences in access to care and treatment as well as diagnostic deliberation may affect gender-specific differences in liver disease progression. Apart from the pathogenesis, xenobiotic metabolism, immune responses, gene expressions, mitochondrial function, lipid composition, and enzyme activities also differ in this sexually dimorphic organ...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28930061/promoting-adoption-of-medication-for-opioid-and-alcohol-use-disorders-through-system-change
#13
James H Ford, Amanda J Abraham, Nicoleta Lupulescu-Mann, Raina Croff, Kim A Hoffman, Kelly Alanis-Hirsch, Mady Chalk, Laura Schmidt, Dennis McCarty
OBJECTIVE: The Medication Research Partnership (MRP), a collaboration between a national commercial health plan and nine addiction treatment centers, implemented organizational and system changes to promote use of federally approved medications for treatment of alcohol and opioid use disorders. METHOD: A difference-in-differences analysis examined change over time in the percentage of patients receiving a prescription medication for alcohol or opioid use disorders treated in MRP (n = 9) and comparison (n = 15) sites...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929879/safer-muslim-motherhood-social-conditions-and-maternal-mortality-in-the-muslim-world
#14
Kylea Laina Liese, Angela B Maeder
The greatest variation in maternal mortality is among poor countries and wealthy countries that rely on emergency obstetric technology to save a woman's life during childbirth. However, substantial variation in maternal mortality ratios (MMRs) exists within and among poor countries with uneven access to advanced obstetric services. This article examines MMRs across the Muslim world and compares the impact of national wealth, female education, and skilled birth attendants on maternal mortality. Understanding how poor countries have lowered MMRs without access to expensive obstetric technologies suggests that certain social variables may act protectively to reduce the maternal risk for life-threatening obstetric complications that would require emergency obstetric care...
September 20, 2017: Global Public Health
https://www.readbyqxmd.com/read/28929778/direct-percutaneous-endoscopic-jejunostomy-should-we-move-on-to-single-and-double-balloon-enteroscopy-techniques
#15
Klaus Mönkemüller, Carolina Olano, Steffen Rickes
Direct percutaneous endoscopic jejunostomy (DPEJ) is a useful technique to access the jejunum in order to a) provide enteral nutrition to individuals when the gastric route is absent or contraindicated, and b) to decompress the jejunum in patients with malignant small bowel obstruction. Traditionally, DPEJ is performed using a colonoscope or enteroscope, which is advanced as deep as possible into the jejunum. The insertion technique of the feeding tube is identical to the one used for a gastrostomy tube (Ponsky-Gauderer method)...
September 18, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28929537/the-value-of-local-registry-data-for-describing-cervical-cancer-management-and-outcomes-over-three-decades-in-australia
#16
D Roder, M Davy, S Selva-Nayagam, R Gowda, S Paramasivam, J Adams, D Keefe, M Eckert, K Powell, K Fusco, D Buranyi-Trevarton, M K Oehler
Registry data on invasive cervical cancers (n = 1,274) from four major hospitals (1984-2012) were analysed to determine their value for informing local service delivery in Australia. The methodology comprised disease-specific survival analyses using Kaplan-Meier product-limit estimates and Cox proportional hazards models and treatment analyses using logistic regression. Five- and 10-year survivals were 72% and 68%, respectively, equating with relative survival estimates for Australia and the USA. Most common treatments were surgery and radiotherapy...
September 20, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28927493/review-of-patient-reported-experience-within-patient-centered-medical-homes-insights-for-australian-health-care-homes
#17
Mary O'Loughlin, Jane Mills, Robyn McDermott, Linton Harriss
Understanding patient experience is necessary to advance the patient-centred approach to health service delivery. Australia's primary healthcare model, the 'Health Care Home', is based on the 'Patient-Centered Medical Home' (PCMH) model developed in the United States. Both these models aim to improve patient experience; however, the majority of existing PCMH model evaluations have focussed on funding, management and quality assurance measures. This review investigated the scope of evidence reported by adult patients using a PCMH...
September 20, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28926423/a-noninterventional-multicenter-prospective-phase-iv-study-of-trabectedin-in-patients-with-advanced-soft-tissue-sarcoma
#18
Angela Buonadonna, Charlotte Benson, Jose Casanova, Bernd Kasper, Antonio López Pousa, Filomena Mazzeo, Thomas Brodowicz, Nicolas Penel
This prospective, noninterventional study is the first phase IV trial designed to evaluate trabectedin in patients with advanced soft tissue sarcoma in real-life clinical practice across Europe. To be included in the study, patients must have received more than or equal to one cycle of trabectedin and be currently on treatment. The primary endpoint was progression-free survival as defined by investigators. The secondary endpoints included objective response rate, disease control rate, time to progression and the growth modulation index (GMI), overall survival, and an assessment of the cancer-related symptoms and safety...
September 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28926357/first-in-human-treatment-with-a-dendritic-cell-targeting-lentiviral-vector-expressing-ny-eso-1-lv305-induces-deep-durable-response-in-refractory-metastatic-synovial-sarcoma-patient
#19
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
September 18, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28925939/process-and-pitfalls-of-sperm-cryopreservation
#20
REVIEW
Hamoun Rozati, Thomas Handley, Channa Jayasena
Sperm cryopreservation has been utilized routinely for over 40 years to preserve fertility in men undergoing cancer therapy and allow conception for infertile couples. This article provides a concise and up-to-date review of the literature and covers the latest advances in sperm cryopreservation and its array of clinical indications. Over recent years, the scope of clinical indications used for sperm cryopreservation has expanded widely. Consequently, more patient groups are eligible for sperm freezing, requiring specialist resources and higher running costs...
September 19, 2017: Journal of Clinical Medicine
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