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https://www.readbyqxmd.com/read/28546869/smoking-alcohol-and-drug-use-in-youth-and-adults-with-attention-deficit-hyperactivity-disorder
#1
Sydney Osland, Lauren Hirsch, Tamara Pringsheim
BACKGROUND: Previous research suggests a relationship between attention-deficit hyperactivity disorder (ADHD) and smoking, alcohol and illicit drug use, however most studies have focused on adolescents or young adults, or clinically ascertained samples. AIMS: To analyse population-based data on the relationship between ADHD and at-risk health behaviours in adolescents and adults. METHOD: Data were derived from a Statistics Canada population-based health survey...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28546828/improving-the-thermostability-of-a-fungal-gh11-xylanase-via-site-directed-mutagenesis-guided-by-sequence-and-structural-analysis
#2
Nanyu Han, Huabiao Miao, Junmei Ding, Junjun Li, Yuelin Mu, Junpei Zhou, Zunxi Huang
BACKGROUND: Xylanases have been widely employed in many industrial processes, and thermophilic xylanases are in great demand for meeting the high-temperature requirements of biotechnological treatments. In this work, we aim to improve the thermostability of XynCDBFV, a glycoside hydrolase (GH) family 11 xylanase from the ruminal fungus Neocallimastix patriciarum, by site-directed mutagenesis. We report favorable mutations at the C-terminus from B-factor comparison and multiple sequence alignment...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28546043/mynx-vascular-closure-device-in-arterial-endovascular-procedures
#3
Michael C Scott, Horace J Spencer, Ahsan T Ali, Mohammed M Moursi, Guillermo A Escobar, Lewis C Lyons, Matthew R Smeds
OBJECTIVE: Vascular closure devices have been used to achieve hemostasis of percutaneous access sites following endovascular procedures, with reported decreased time for arterial control as well as decreased time to ambulation. We sought to determine rates and risk factors of postoperative bleeding complications and failures using these devices from a single institution experienced in the use of vascular closure devices. METHODS: All patients undergoing arterial endovascular procedures with percutaneous access between March 2010 and October 2015 at a single institution were identified and analyzed (n=894)...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28545835/omniphr-a-distributed-architecture-model-to-integrate-personal-health-records
#4
Alex Roehrs, Cristiano André da Costa, Rodrigo da Rosa Righi
The advances in the Information and Communications Technology (ICT) brought many benefits to the healthcare area, specially to digital storage of patients' health records. However, it is still a challenge to have a unified viewpoint of patients' health history, because typically health data is scattered among different health organizations. Furthermore, there are several standards for these records, some of them open and others proprietary. Usually health records are stored in databases within health organizations and rarely have external access...
May 22, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28545789/frequency-of-somatic-symptoms-in-the-general-population-normative-values-for-the-patient-health-questionnaire-15-phq-15
#5
Andreas Hinz, Jochen Ernst, Heide Glaesmer, Elmar Brähler, Franziska G Rauscher, Katja Petrowski, Rüya-Daniela Kocalevent
BACKGROUND: The PHQ-15 is widely used as an open access screening instrument for somatic symptoms in different health care settings. The objectives of the study were to contribute to the construct validity and to generate normative data for the PHQ-15. METHODS: The survey was conducted in the general population in Germany from August 2011 to November 2014 (n=9250). All participants underwent an extensive core assessment including a set of questionnaires. RESULTS: Men reported significantly less (p<0...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28545460/intraperitoneal-implantation-of-life-long-telemetry-transmitters-in-three-rehabilitated-harbor-seal-pups
#6
Markus Horning, Martin Haulena, Justin F Rosenberg, Chad Nordstrom
BACKGROUND: Pinnipeds, including many phocid species of concern, are inaccessible and difficult to monitor for extended periods using conventional, externally attached telemetry devices that are shed during the annual molt. Archival satellite transmitters were implanted intraperitoneally into three stranded Pacific harbor seal pups (Phoca vitulina richardii) that completed rehabilitation, to evaluate the viability of this surgical technique for the deployment of life long telemetry devices in phocids...
May 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28545427/advantages-and-limitations-for-users-of-double-pit-pour-flush-latrines-a-qualitative-study-in-rural-bangladesh
#7
Faruqe Hussain, Thomas Clasen, Shahinoor Akter, Victoria Bawel, Stephen P Luby, Elli Leontsini, Leanne Unicomb, Milan Kanti Barua, Brittany Thomas, Peter J Winch
BACKGROUND: In rural Bangladesh, India and elsewhere, pour-flush pit latrines are the most common sanitation system. When a single pit latrine becomes full, users must empty it themselves and risk exposure to fresh feces, pay an emptying service to remove pit contents or build a new latrine. Double pit pour-flush latrines may serve as a long-term sanitation option including high water table areas because the pits do not need to be emptied immediately and the excreta decomposes into reusable soil...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28545393/quantgenius-implementation-of-a-decision-support-system-for-qpcr-based-gene-quantification
#8
Špela Baebler, Miha Svalina, Marko Petek, Katja Stare, Ana Rotter, Maruša Pompe-Novak, Kristina Gruden
BACKGROUND: Quantitative molecular biology remains a challenge for researchers due to inconsistent approaches for control of errors in the final results. Due to several factors that can influence the final result, quantitative analysis and interpretation of qPCR data are still not trivial. Together with the development of high-throughput qPCR platforms, there is a need for a tool allowing for robust, reliable and fast nucleic acid quantification. RESULTS: We have developed "quantGenius" ( http://quantgenius...
May 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28545242/public-open-spaces-and-leisure-time-walking-in-brazilian-adults
#9
Alex Antonio Florindo, Ligia Vizeu Barrozo, William Cabral-Miranda, Eduardo Quieroti Rodrigues, Gavin Turrell, Moisés Goldbaum, Chester Luiz Galvão Cesar, Billie Giles-Corti
Access to public open space is important to increase leisure-time walking (LTW) in high-income countries, but there is little evidence in middle-income countries. We conducted a cross-sectional analysis to examine the relationship between LTW and the presence of different public open spaces (parks, bike paths, and squares) and the mix of these recreational destinations near the homes of adults participating in the Sao Paulo Health Survey (n = 3145). LTW was evaluated by a questionnaire. We delineated buffers (500, 1000, and 1500 m) from the geographic coordinates of the adults' residential addresses using a geographic information system...
May 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28544471/aziridine-mediated-ligation-at-phenylalanine-and-tryptophan-sites
#10
Kiran Bajaj, Rajeev Sakhuja
An efficient approach towards peptide synthesis has been described that allows an easy access to variety of small peptides via one-pot aziridine-mediated ligation-desulfurization strategy. The present protocol afforded a library of phenylalanine and tryptophan containing α-peptides in good yields by regioselective ring-opening of aziridine-3-aryl-2-carboxylates with peptide thioacids followed by desulfurization.
May 23, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28544277/use-of-a-vascular-closure-device-during-percutaneous-arterial-access-in-a-dog-with-impaired-hemostasis
#11
Brian A Scansen, Caitlin M Hokanson, Steven G Friedenberg, Hooman Khabiri
OBJECTIVE: To report the use of a vascular closure device (VCD) to provide rapid arterial hemostasis following percutaneous femoral arterial catheterization and diagnostic angiography in a thrombocytopenic and coagulopathic dog. CASE SUMMARY: A 6-year-old female spayed Kai Ken Tora dog presented after vehicular trauma. The dog was diagnosed with traumatic pneumothorax, degloving wounds of the right antebrachium, subcutaneous hemorrhage within the axillary tissues of the left thoracic limb, and anemia and thrombocytopenia secondary to acute hemorrhage...
May 23, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28544231/dual-responsive-molecular-switches-based-on-dithienylethene-ru-ii-organometallics-in-self-assembled-monolayers-operating-at-low-voltage
#12
Andrea Mulas, Xiaoyan He, Yves-Marie Hervault, Lucie Norel, Stéphane Rigaut, Corinne Lagrost
Two carbon-rich ruthenium complexes bearing a dithienylethene (DTE) unit and a hexylthiol spacer were designed to be attached on gold surfaces. Both compounds display photochemically-driven switching properties, allowing reversible conversion from open to closed forms of the DTE units upon irradiation in solution. In contrast, only the bimetallic complex undergoes an efficient electrochemical ring closure at low potential, (0.5 V vs SCE), whereas the monometallic complex show a simple one electron reversible redox event...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543615/improved-image-quality-and-reduced-power-deposition-in-the-spine-at-3-t-using-extremely-high-permittivity-materials
#13
Kirsten Koolstra, Peter Börnert, Wyger Brink, Andrew Webb
PURPOSE: To explore the effect of using extremely high permittivity (εr ∼1,000) materials on image quality and power requirements of spine imaging at 3 T. THEORY AND METHODS: A linear array of high permittivity dielectric blocks made of lead zirconate titanate (PZT) was designed and characterized by electromagnetic simulations and experiments. Their effect on the transmit efficiency, receive sensitivity, power deposition, and diagnostic image quality was analyzed in vivo in 10 healthy volunteers...
May 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28543430/planet-an-ellipse-fitting-approach-for-simultaneous-t1-and-t2-mapping-using-phase-cycled-balanced-steady-state-free-precession
#14
Yulia Shcherbakova, Cornelis A T van den Berg, Chrit T W Moonen, Lambertus W Bartels
PURPOSE: To demonstrate the feasibility of a novel, ellipse fitting approach, named PLANET, for simultaneous estimation of relaxation times T1 and T2 from a single 3D phase-cycled balanced steady-state free precession (bSSFP) sequence. METHODS: A method is presented in which the elliptical signal model is used to describe the phase-cycled bSSFP steady-state signal. The fitting of the model to the acquired data is reformulated into a linear convex problem, which is solved directly by a linear least squares method, specific to ellipses...
May 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28542080/manuscript-title-multidisciplinary-point-of-care-testing-in-south-african-primary-healthcare-clinics-accelerates-hiv-art-initiation-but-does-not-alter-retention-in-care
#15
Wendy S Stevens, Natasha M Gous, William B MacLeod, Lawrence C Long, Ebrahim Variava, Neil A Martinson, Ian Sanne, Regina Osih, Lesley E Scott
BACKGROUND: Lack of accessible laboratory infrastructure limits HIV antiretroviral (ART) treatment initiation, monitoring and retention in many resource-limited settings. Point-of-care testing (POCT) is advocated as a mechanism to overcome these limitations. We executed a pragmatic, prospective, randomized, controlled trial comparing the impact of POCT versus standard-of-care (SOC) on treatment initiation and retention in care. METHOD: Selected POC technologies were embedded at 3 primary health clinics in South Africa...
May 23, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28542038/hypoxia-as-a-target-for-drug-combination-therapy-of-liver-cancer
#16
Cressida Bowyer, Andrew L Lewis, Andrew W Lloyd, Gary J Phillips, Wendy M Macfarlane
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths worldwide. The standard of care for intermediate HCC is transarterial chemoembolization, which combines tumour embolization with locoregional delivery of the chemotherapeutic doxorubicin. Embolization therapies induce hypoxia, leading to the escape and proliferation of hypoxia-adapted cancer cells. The transcription factor that orchestrates responses to hypoxia is hypoxia-inducible factor 1 (HIF-1). The aim of this work is to show that targeting HIF-1 with combined drug therapy presents an opportunity for improving outcomes for HCC treatment...
May 24, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28542036/a-survey-of-renal-impairment-pharmacokinetic-studies-for-new-oncology-drug-approvals-in-the-usa-from-2010-to-early-2015-a-focus-on-development-strategies-and-future-directions
#17
Jim J Xiao, Jiyun S Chen, Bert L Lum, Richard A Graham
The US Food and Drug Administration (FDA) issued a guidance document in 2010 on pharmacokinetic (PK) studies in renal impairment (RI) on the basis of observations that substances such as uremic toxins might result in altered drug metabolism and excretion. No specific recommendations for oncology drugs were included. We surveyed the publicly available FDA review documents of 29 small molecule oncology drugs approved between 2010 and the first quarter of 2015. The objectives were as follows: (i) summarize the impact of RI on PK at the time of the initial new drug application; (ii) identify limitations of the guidance; and (iii) outline an integrated approach to study the impact of RI on these drugs...
May 24, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28542020/ciclovia-in-a-rural-latino-community-results-and-lessons-learned
#18
Cynthia K Perry, Linda K Ko, Lidia Hernandez, Rosa Ortiz, Sandra Linde
CONTEXT: Ciclovias involve the temporary closure of roads to motorized vehicles, allowing for use by bicyclists, walkers, and runners and for other physical activity. Ciclovias have been held in urban and suburban communities in the United States and Latin America. OBJECTIVE: We evaluated the first ciclovia held in a rural, predominantly Latino community in Washington State. SETTING: Three blocks within a downtown area in a rural community were closed for 5 hours on a Saturday in July 2015...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28541960/clinical-features-of-treated-and-untreated-type-1-idiopathic-macular-telangiectasia-without-the-occurrence-of-secondary-choroidal-neovascularization-followed-for-2-years-in-japanese-patients
#19
Rie Osaka, Chieko Shiragami, Aoi Ono, Mamoru Kobayashi, Yukari Takasago, Ayana Yamashita, Akitaka Tsujikawa
PURPOSE: To evaluate the clinical features of Type 1 idiopathic macular telangiectasia (IMT) followed up for 2 years. METHODS: Forty-nine patients with unilateral Type 1 IMT were examined. Thirty-one IMT eyes were treated with direct laser photocoagulation and/or intravitreal bevacizumab; the remaining 18 eyes, with good vision or slight macular edema, were untreated. Changes in best-corrected visual acuity and central retinal thickness between baseline and 24 months after the initial visit were examined...
May 24, 2017: Retina
https://www.readbyqxmd.com/read/28541579/tailored-extended-bifrontal-craniotomy-for-anterior-skull-base-tumors-anatomic-description-of-a-modified-surgical-technique-and-case-series
#20
Michael M Safaee, Michael W McDermott, Arnau Benet, Philip V Theodosopoulos
BACKGROUND: Open transcranial approaches to the anterior skull base remain an integral component of current skull base practice. Evolution of these and other techniques has resulted in revisions of standard, tried-and-true methods in attempts to improve patient outcomes and cosmesis, while still providing the best combination of surgical exposure and ergonomics. OBJECTIVE: To describe a modified approach for midline tumors of the anterior skull base. METHODS: We describe the anatomy and techniques of a modified extended bifrontal craniotomy for anterior skull base tumors...
May 24, 2017: Operative Neurosurgery (Hagerstown, Md.)
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