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https://www.readbyqxmd.com/read/28748053/allogeneic-stem-cells-derived-from-human-exfoliated-deciduous-teeth-shed-for-the-management-of-periapical-lesions-in-permanent-teeth-two-case-reports-of-a-novel-biologic-alternative-treatment
#1
Madu Ghana Shyam Prasad, Juvva Ramakrishna, Duvvi Naveen Babu
Stem cells are the pluripotent cells that have the capacity to differentiate into other specialized cells. Recently, many experiments have been conducted to study the potentiality of stem cells in the tissue regeneration. We report two cases treated utilizing stem cells from human exfoliated deciduous teeth (SHED) in the management of periapical lesions in permanent teeth. Two normal human deciduous teeth from children, 7‒8 years of age, were collected to isolate stem cells. Two patients, one with periapical pathology alone and the other with periapical lesion along with an open apex in young permanent teeth, were selected for the study...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28746591/the-therapeutic-challenge-of-giant-splenic-artery-aneurysm-a-case-repport
#2
Paulo Kauffman, Antonio Luiz de Vasconcellos Macedo, Roberto Sacilotto, Adriano Tachibana, Sergio Kuzniec, Lucas Lembrança Pinheiro, Nelson Wolosker
Giant splenic artery aneurysm is a rare condition that represents an eminent life threatening for the patient, requiring, therefore, urgent surgical correction. A 61-year-old woman, former smoker, hypertensive, hypercholesterolemic and multipara sought our service because of a large tumor in the mesogastrium, which was an abdominal ultrasound finding. Despite the size of the tumor, the patient was asymptomatic. The angiotomography and the magnetic resonance image of the abdomen were suggestive of giant splenic artery aneurysm with more than 10cm in diameter that was confirmed by an angiography...
July 24, 2017: Einstein
https://www.readbyqxmd.com/read/28746165/effect-of-immediate-initiation-of-antiretroviral-treatment-in-hiv-positive-individuals-aged-50-years-or-older
#3
Sara Lodi, Dominique Costagliola, Caroline Sabin, Julia Del Amo, Roger Logan, Sophie Abgrall, Peter Reiss, Ard van Sighem, Sophie Jose, Jose-Ramon Blanco, Victoria Hernando, Heiner C Bucher, Helen Kovari, Ferran Segura, Juan Ambrosioni, Charalambos A Gogos, Nikos Pantazis, Francois Dabis, Marie-Anne Vandenhende, Laurence Meyer, Rémonie Seng, John Gill, Hartmut Krentz, Andrew Phillips, Kholoud Porter, Beatriz Grinsztejn, Antonio G Pacheco, Roberto Muga, Janet Tate, Amy Justice, Miguel A Hernán
BACKGROUND: Clinical guidelines recommend immediate initiation of combined antiretroviral therapy (ART) for all HIV-positive individuals. However, those guidelines are based on trials of relatively young participants. METHODS: We included HIV-positive ART-naïve, AIDS-free individuals aged 50-70 years after 2004 in the HIV-CAUSAL Collaboration. We used the parametric g-formula to estimate the 5-year risk of all-cause and non-AIDS mortality under: i) immediate initiation at baseline, and initiation at CD4 count ii) <500 cells/mm, and iii) <350 cells/mm...
July 21, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28746163/the-potential-contribution-of-dietary-factors-to-breast-cancer-prevention
#4
Niva Shapira
Breast cancer (BC), the leading cancer in women, is increasing in prevalence worldwide, concurrent with western metabolic epidemics, that is, obesity, metabolic syndrome, and diabetes, and shares major risk factors with these diseases. The corresponding potential for nutritional contributions toward BC prevention is reviewed and related to critical stages in the life cycle and their implications for carcinogenic and pathometabolic trajectories. BC initiation potentially involves diet-related pro-oxidative, inflammatory, and procarcinogenic processes, that interact through combined lipid/fatty acid peroxidation, estrogen metabolism, and related DNA-adduct/depurination/mutation formation...
July 25, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28746066/automatic-honesty-forgoing-reward-acquisition-and-punishment-avoidance-a-functional-mri-investigation
#5
Mei Yoneda, Ryuhei Ueda, Hiroshi Ashida, Nobuhito Abe
Recent neuroimaging investigations into human honesty suggest that honest moral decisions in individuals who consistently behave honestly occur automatically, without the need for active self-control. However, it remains unclear whether this observation can be applied to two different types of honesty: honesty forgoing dishonest reward acquisition and honesty forgoing dishonest punishment avoidance. To address this issue, a functional MRI study, using an incentivized prediction task in which participants were confronted with real and repeated opportunities for dishonest gain leading to reward acquisition and punishment avoidance, was conducted...
July 25, 2017: Neuroreport
https://www.readbyqxmd.com/read/28746064/precannulated-fenestrated-endovascular-aneurysm-repair-using-guidewire-fixator-a-novel-method-using-the-liungman-guidewire-fixator
#6
Linus Bosaeus, Kevin Mani, Anders Wanhainen, Krister Liungman
OBJECTIVE: By using a guidewire fixator, the distal guidewire position can be secured in an artery. This new principle enables a method for fenestrated endovascular aortic repair where the connection between the aortic branches and the stent graft fenestrations is made before inserting and deploying the stent graft. METHODS: This is conducted using a fenestrated stent graft with preloaded catheters, through which the prepositioned and distally secured guidewires from the branches are inserted...
July 25, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28745008/-you-cannot-collect-data-using-your-own-resources-and-put-it-on-open-access-perspectives-from-africa-about-public-health-data-sharing
#7
Evelyn Anane-Sarpong, Tenzin Wangmo, Claire Leonie Ward, Osman Sankoh, Marcel Tanner, Bernice Simone Elger
Data-sharing is a desired default in the field of public health and a source of much ethical deliberation. Sharing data potentially contributes the largest, most efficient source of scientific data, but is fraught with contextual challenges which make stakeholders, particularly those in under-resourced contexts hesitant or slow to share. Relatively little empirical research has engaged stakeholders in discussing the issue. This study sought to explore relevant experiences, contextual, and subjective explanations around the topic to provide a rich and detailed presentation of what it means to different stakeholders and contexts to share data and how that can guide practice and ethical guidance...
July 25, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28743931/topological-heat-transport-and-symmetry-protected-boson-currents
#8
Ángel Rivas, Miguel A Martin-Delgado
The study of non-equilibrium properties in topological systems is of practical and fundamental importance. Here, we analyze the stationary properties of a two-dimensional bosonic Hofstadter lattice coupled to two thermal baths in the quantum open-system formalism. Novel phenomena appear like chiral edge heat currents that are the out-of-equilibrium counterparts of the zero-temperature edge currents. They support a new concept of dissipative symmetry-protection, where a set of discrete symmetries protects topological heat currents, differing from the symmetry-protection devised in closed systems and zero-temperature...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743591/terminology-supported-archiving-and-publication-of-environmental-science-data-in-pangaea-open-access
#9
Michael Diepenbroek, Uwe Schindler, Robert Huber, Stéphane Pesant, Markus Stocker, Janine Felden, Melanie Buss, Matthias Weinrebe
Exemplified on the information system PANGAEA, we describe the application of terminologies for archiving and publishing environmental science data. A Terminology Catalogue (TC) was embedded into the system, with interfaces allowing to replicate and to manually work on terminologies. For data ingest and archiving, we show how the TC can improve structuring and harmonizing lineage and content descriptions of data sets. Key is the conceptualization of measurement and observation types (parameters) and methods, for which we have implemented a basic syntax and rule set...
July 22, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28742763/implementation-of-a-national-workplace-wellness-program-for-health-workers-in-botswana
#10
Jenny H Ledikwe, Bazghina-Werq Semo, Miram Sebego, Maureen Mpho, Heather Mothibedi, Shreshth Mawandia, Gabrielle O'Malley
: The Botswana workplace wellness program (WWP) for health care workers (HCWs) was initiated in 2007. WWP implementation was assessed using a sequential, explanatory, mixed methods design including a national implementation assessment (27 health districts) and in-depth interviews (n = 38). Level of implementation varied across districts with health screening, therapeutic recreation, and health promotion implemented more frequently than occupational health activities and psychosocial services. Facilitators to WWP implementation included establishment of a dedicated, diverse WWP committee; provision of administrative support, and integration of activities into organizational culture...
July 24, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28742731/endoscopic-ultrasound-guided-portal-venous-access-diagnostic-and-therapeutic-implications
#11
Rajat Garg, Tarun Rustagi
Endoscopic ultrasound (EUS) has evolved from a purely diagnostic to an interventional modality offering minimally invasive alternatives to surgical and radiologic interventions. This has led to a rapidly growing interest in EUS-guided vascular interventions. EUS-guided portal venous access is an emerging technique which opens a new arena for interventional vascular EUS. Portal vein can be accessed under EUS guidance with high precision and low risk of complications thus expanding its application for both benign and malignant conditions...
July 24, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28742547/celiprolol-a-unique-selective-adrenoceptor-modulator
#12
James J Nawarskas, Angela Cheng-Lai, William H Frishman
Celiprolol is a β-blocker with a unique pharmacologic profile: it is a β1-andrenoceptor antagonist with partial β2 agonist activity. Given this combination of effects, celiprolol may be better described as a elective adrenoreceptor modulator. It has antihypertensive and antianginal properties and is indicated for those uses in various countries around the world. In the United States, however, the proposed indication for this drug will be for the treatment of vascular type Ehlers-Danlos syndrome, a rare connective tissue isorder haracterized by fragile arterial structure and an increased risk of life-threatening vascular complications...
July 20, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28742545/reductions-in-readmission-rates-are-associated-with-modest-improvements-in-patient-reported-health-gains-following-hip-and-knee-replacement-in-england
#13
Rocco Friebel, Kumar Dharmarajan, Harlan M Krumholz, Adam Steventon
BACKGROUND: Although many hospital readmission reduction initiatives have been introduced globally, health care systems ultimately aim to improve patients' health and well-being. We examined whether the hospitals that report greater success in reducing readmissions also see greater improvements in patient-reported outcomes. RESEARCH DESIGN: We examined hospital groups (Trusts) that provided hip replacement or knee replacement surgery in England between April 2010 and February 2013...
July 24, 2017: Medical Care
https://www.readbyqxmd.com/read/28742542/clinical-practice-guidelines-for-cryosurgery-of-pancreatic-cancer-a-consensus-statement-from-the-china-cooperative-group-of-cryosurgery-on-pancreatic-cancer-international-society-of-cryosurgery-and-asian-society-of-cryosurgery
#14
Lihua He, Lizhi Niu, Nikolai N Korpan, Sajio Sumida, Yueyong Xiao, Jiaping Li, Barlian Sutedja, Youyong Lu, Jiansheng Zuo, Jianguo Liu, Kecheng Xu
Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. Cryosurgery was first used in 1984 for treatment of locally advanced PC and has since become a considerable treatment for most cases of unresectable PC. During the past decade, cryosurgery has been applied in some hospitals in China, and the newly developed technique of computed tomography- and/or ultrasound-guided percutaneous cryosurgery has shown better results than chemotherapy in cases of unresectable locally advanced PC, with the 1-year survival rate reported to be more than 50%...
July 24, 2017: Pancreas
https://www.readbyqxmd.com/read/28742134/hemostasis-pad-combined-with-compression-device-after-transradial-coronary-procedures-a-randomized-controlled-trial
#15
Si-Hyuck Kang, Donghoon Han, Sehun Kim, Chang-Hwan Yoon, Jin-Joo Park, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae
BACKGROUND: Arterial access and hemostasis are important processes during percutaneous coronary procedures. In this study, we tested if the use of chitosan-based pads on top of compression devices could improve hemostasis efficacy compared with compression devices alone after transradial coronary angiography or interventions. METHODS: This study was a single-center open-label randomized controlled trial. Patients who underwent coronary angiography or intervention with the transradial approach were randomly assigned to the study (compression device and a chitosan-based pad) or control (compression devices alone) group in a 2:1 fashion...
2017: PloS One
https://www.readbyqxmd.com/read/28741334/endovascular-treatment-of-chronic-occluded-popliteal-artery-aneurysm-early-and-mid-term-outcomes
#16
Vincenzo Ardita, Alessia Giaquinta, Matteo Orrico, Sonia Ronchey, Massimiliano Veroux, Nicola Mangialardi, Pierfrancesco Veroux
BACKGROUND: Critical limb ischemia (CLI) may be the consequence of chronic occluded popliteal artery aneurysm (PAA). Open repair (OR) offers better 5-year results than endovascular treatment, but in patients with severe comorbidities or unfit to OR, endovascular repair (ER) could represent a valid treatment option. The purpose of this retrospective study was to review our experience of endovascular popliteal aneurism repair (EVPAR) in patients with chronic occluded PAA. METHODS: The endpoints assessed were: 1- and 3-year primary and secondary patency rates, technical success, 30-day major adverse events, major amputation free-survival, re-intervention and survival rates...
July 24, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28741303/open-retropubic-colposuspension-for-urinary-incontinence-in-women
#17
REVIEW
Marie Carmela M Lapitan, June D Cody, Atefeh Mashayekhi
BACKGROUND: Urinary incontinence is a common and potentially debilitating problem. Stress urinary, incontinence as the most common type of incontinence, imposes significant health and economic burdens on society and the women affected. Open retropubic colposuspension is a surgical treatment which involves lifting the tissues near the bladder neck and proximal urethra in the area behind the anterior pubic bones to correct deficient urethral closure to correct stress urinary incontinence...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28740733/when-is-evidence-enough-evidence-a-systematic-review-and-meta-analysis-of-the-trabectome-as-a-solo-procedure-in-patients-with-primary-open-angle-glaucoma
#18
REVIEW
Jeffrey T Y Chow, Cindy M L Hutnik, Karla Solo, Monali S Malvankar-Mehta
The purpose of this systematic review and meta-analysis was to examine the availability of evidence for one of the earliest available minimally invasive glaucoma surgery (MIGS) procedures, the Trabectome. Various databases were searched up to December 20, 2016, for any published studies assessing the use of the Trabectome as a solo procedure in patients with primary open-angle glaucoma (POAG). The standardized mean differences (SMD) were calculated for the change in intraocular pressure (IOP) and number of glaucoma mediations used at 1-month, 6-month, and 12-month follow-up...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28740619/should-new-health-technology-be-available-only-for-patients-able-and-willing-to-pay
#19
REVIEW
Piet Calcoen, Albert Boer, Wynand P M M van de Ven
New health technology comes on the market at a rapid pace and - sometimes - at a huge cost. Providing access to new health technology is a serious challenge for many countries with mandatory health insurance. This article analyses access to new health technology in Belgium and the Netherlands, using eight concrete examples as a starting point for comparing the two - neighbouring - countries. Contrary to the Netherlands, out-of-pocket payments for new health technology are widely accepted and practiced in Belgium...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/28740616/unlocking-the-potential-of-established-products-toward-new-incentives-rewarding-innovation-in-europe
#20
Gabrielle Nayroles, Sandrine Frybourg, Sylvie Gabriel, Åsa Kornfeld, Fernando Antoñanzas-Villar, Jaime Espín, Claudio Jommi, Nello Martini, Gérard de Pouvourville, Keith Tolley, Jürgen Wasem, Mondher Toumi
Background: Many established products (EPs - marketed for eight years or more) are widely used off-label despite little evidence on benefit-risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D for EPs. The objective of this research was to describe incentives and disincentives for developing new indications for EPs in Europe and to investigate consequences of current policies...
2017: Journal of Market Access & Health Policy
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