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https://www.readbyqxmd.com/read/29793153/effects-of-mg-2-on-recovery-of-nmda-receptors-from-inhibition-by-memantine-and-ketamine-reveal-properties-of-a-second-site
#1
Nathan G Glasgow, Madeleine R Wilcox, Jon W Johnson
Memantine and ketamine are NMDA receptor (NMDAR) open channel blockers that are thought to act via similar mechanisms at NMDARs, but exhibit divergent clinical effects. Both drugs act by entering open NMDARs and binding at a site deep within the ion channel (the deep site) at which the endogenous NMDAR channel blocker Mg2+ also binds. Under physiological conditions, Mg2+ increases the IC50 s of memantine and ketamine through competition for binding at the deep site. Memantine also can inhibit NMDARs after associating with a second site accessible in the absence of agonist, a process termed second site inhibition (SSI) that is not observed with ketamine...
May 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29792667/control-of-selectivity-in-palladium-ii-catalyzed-oxidative-transformations-of-allenes
#2
Bin Yang, Youai Qiu, Jan-E Bäckvall
Oxidation reactions play a central role in organic synthesis, and it is highly desirable that these reactions are mild and occur under catalytic conditions. In Nature, oxidation reactions occur under mild conditions via cascade processes, and furthermore, they often occur in an enantioselective manner with many of them involving molecular oxygen or hydrogen peroxide as the terminal oxidant. Inspired by the reactions in Nature, we have developed a number of Pd(II)-catalyzed cascade reactions under mild oxidative conditions...
May 24, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29791708/d3-extended-mesenterectomy-in-right-colectomy-for-cancer-a-cadaver-simulation-model
#3
Karen You, Mahir Gachabayov, Jens Marius Nesgaard, Jela Bandovic, Dejan Ignjatovic, Arne Bakka, Roberto Bergamaschi
BACKGROUND: D3 extended mesenterectomy (D3EM) for right colon cancer has received increased attention owing to suggested improvement of oncological outcomes. The aim of this study was to evaluate the proficiency-based progression of content-valid metrics in a cadaveric model for right colectomy with D3EM. MATERIALS AND METHODS: Three expert surgeons were enrolled. Surgeon one performed the procedure robotically and surgeons two and three performed open D3EM. Proficiency-based progression was recorded for eight content-valid outcomes...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29790989/the-galaxy-platform-for-accessible-reproducible-and-collaborative-biomedical-analyses-2018-update
#4
Enis Afgan, Dannon Baker, Bérénice Batut, Marius van den Beek, Dave Bouvier, Martin Cech, John Chilton, Dave Clements, Nate Coraor, Björn A Grüning, Aysam Guerler, Jennifer Hillman-Jackson, Saskia Hiltemann, Vahid Jalili, Helena Rasche, Nicola Soranzo, Jeremy Goecks, James Taylor, Anton Nekrutenko, Daniel Blankenberg
Galaxy (homepage: https://galaxyproject.org, main public server: https://usegalaxy.org) is a web-based scientific analysis platform used by tens of thousands of scientists across the world to analyze large biomedical datasets such as those found in genomics, proteomics, metabolomics and imaging. Started in 2005, Galaxy continues to focus on three key challenges of data-driven biomedical science: making analyses accessible to all researchers, ensuring analyses are completely reproducible, and making it simple to communicate analyses so that they can be reused and extended...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29790940/pycotools-a-python-toolbox-for-copasi
#5
Ciaran M Welsh, Nicola Fullard, Carole J Proctor, Alvaro Martinez-Guimera, Robert J Isfort, Charles C Bascom, Ryan Tasseff, Stefan A Przyborski, Daryl P Shanley
Motivation: COPASI is an open source software package for constructing, simulating and analysing dynamic models of biochemical networks. COPASI is primarily intended to be used with a graphical user interface but often it is desirable to be able to access COPASI features programmatically, with a high level interface. Results: PyCoTools is a Python package aimed at providing a high level interface to COPASI tasks with an emphasis on model calibration. PyCoTools enables the construction of COPASI models and the execution of a subset of COPASI tasks including time courses, parameter scans and parameter estimations...
May 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29790939/nextstrain-real-time-tracking-of-pathogen-evolution
#6
James Hadfield, Colin Megill, Sidney M Bell, John Huddleston, Barney Potter, Charlton Callender, Pavel Sagulenko, Trevor Bedford, Richard A Neher
Summary: Understanding the spread and evolution of pathogens is important for effective public health measures and surveillance. Nextstrain consists of a database of viral genomes, a bioinformatics pipeline for phylodynamics analysis, and an interactive visualisation platform. Together these present a real-time view into the evolution and spread of a range of viral pathogens of high public health importance. The visualization integrates sequence data with other data types such as geographic information, serology, or host species...
May 22, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29790867/fluorine-18-fluorocholine-pet-ct-parameters-predictive-for-hematological-toxicity-to-radium-223-therapy-in-castrate-resistant-prostate-cancer-patients-with-bone-metastases-a-pilot-study
#7
Lavinia Vija Racaru, Mathieu Sinigaglia, Salim Kanoun, Fayçal Ben Bouallègue, Ilan Tal, Sévérine Brillouet, Mathilde Bauriaud-Mallet, Slimane Zerdoud, Lawrence Dierickx, Delphine Vallot, Olivier Caselles, Erwan Gabiache, Pierre Pascal, Frederic Courbon
PURPOSE: This study aims to predict hematological toxicity induced by Ra therapy. We investigated the value of metabolically active bone tumor volume (MBTV) and total bone lesion activity (TLA) calculated on pretreatment fluorine-18-fluorocholine (F-FCH) PET/CT in castrate-resistant prostate cancer (CRPC) patients with bone metastases treated with Ra radionuclide therapy. PATIENTS AND METHODS: F-FCH PET/CT imaging was performed in 15 patients with CRPC before treatment with Ra...
May 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29789858/correction-to-vacuum-assisted-wound-closure-with-mesh-mediated-fascial-traction-achieves-better-outcomes-than-vacuum-assisted-wound-closure-alone-a-comparative-study
#8
Giuseppe Salamone, Leo Licari, Giovanni Guercio, Albert Comelli, Mirko Mangiapane, Nicolò Falco, Roberta Tutino, Noemi Bagarella, Sofia Campanella, Calogero Porrello, Roberto Gullo, Gianfranco Cocorullo, Gaspare Gulotta
In the original article the credit line for the reuse of Fig. 1 from an article published in the open access journal, World Journal of Emergency Surgery is missing.
May 22, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29789729/europe-s-open-access-drive-escalates-as-university-stand-offs-spread
#9
Holly Else
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29789595/endocide-induced-abnormal-growth-forms-of-invasive-giant-salvinia-salvinia-molesta
#10
Shiyou Li, Ping Wang, Zushang Su, Emily Lozano, Olivia LaMaster, Jason B Grogan, Yuhui Weng, Thomas Decker, John Findeisen, Monica McGarrity
Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. The fern is known to have primary, secondary, and tertiary growth forms, which are also commonly hypothesized as growth stages. The identification of these forms is primarily based on the size and folding status of the floating leaves. However, we identified 12 forms in the greenhouse and the field. Our experiments showed that the folding of floating leaves is a reversible trait dependent on water access. The floating leaves quickly fold in response to water shortage, reducing water loss and needs, decreasing growth, and avoiding trichome damage...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789530/efficient-blood-brain-barrier-opening-in-primates-with-neuronavigation-guided-ultrasound-and-real-time-acoustic-mapping
#11
Shih-Ying Wu, Christian Aurup, Carlos Sierra Sanchez, Julien Grondin, Wenlan Zheng, Hermes Kamimura, Vincent P Ferrera, Elisa E Konofagou
Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to open the BBB noninvasively, locally, and transiently and facilitate drug delivery, while translation to the clinic is challenging due to long procedure, targeting limitations, or invasiveness of current systems...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789234/exploring-positive-surgical-margins-after-minimally-invasive-radical-prostatectomy-does-body-habitus-really-make-a-difference
#12
S Albisinni, J Grosman, F Aoun, T Quackels, A Peltier, R Van Velthoven, T Roumeguère
BACKGROUND: Positive surgical margins (PSMs) at radical prostatectomy (RP) are generally recognized as a surrogate of poor or difficult dissection of the prostatic gland. In open RP cohorts, obesity seems to be associated to an increased risk of PSMs, probably due to the technical challenge that obese men pose to surgical access. Minimally invasive RP has been claimed to possibly reduce PSM rate. Aim of the study was to explore the impact of obesity and body habitus on PSM risk and their localisation during laparoscopic and robotic-assisted RP...
May 19, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29789168/quantlc-an-online-open-source-solution-for-videodensitometric-quantification
#13
Dimitri Fichou, Gertrud E Morlock
The image is the key feature of planar chromatography. Videodensitometry by digital image conversion is the fastest way of its evaluation. Instead of scanning single sample tracks one after the other, only few clicks are needed to convert all tracks at one go. A minimalistic software was newly developed, termed quanTLC, that allowed the quantitative evaluation of samples in few minutes. quanTLC includes important assets such as open-source, online, free of charge, intuitive to use and tailored to planar chromatography, as none of the nine existent software for image evaluation covered these aspects altogether...
May 19, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29789077/open-science-in-switzerland
#14
Swiss National Science Foundation
The results of research financed by public funds are regarded as a public good and should be published electronically so that they are immediately and publicly available without charge and can be reused by third parties. The SNSF supports the principle of free accessibility: it has adopted the aim that all publications resulting from its funding will be openly accessible as of 2020. The article is a summary of information provided by the SNSF More information are available on the SNSF website.
May 30, 2018: Chimia
https://www.readbyqxmd.com/read/29788807/evidence-for-telehealth-group-based-treatment-a-systematic-review
#15
Melanie T Gentry, Maria I Lapid, Matthew M Clark, Teresa A Rummans
Background Interest in the use of telehealth interventions to increase access to healthcare services is growing. Group-based interventions have the potential to increase patient access to highly needed services. The aim of this study was to systematically review the available literature on group-based video teleconference services. Methods The English-language literature was searched using Ovid MEDLINE, PubMed, PsycINFO and CINAHL for terms related to telehealth, group therapy and support groups. Abstracts were reviewed for relevance based on inclusion criteria...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29788317/fragfit-a-web-application-for-interactive-modeling-of-protein-segments-into-cryo-em-density-maps
#16
Johanna K S Tiemann, Alexander S Rose, Jochen Ismer, Mitra D Darvish, Tarek Hilal, Christian M T Spahn, Peter W Hildebrand
Cryo-electron microscopy (cryo-EM) is a standard method to determine the three-dimensional structures of molecular complexes. However, easy to use tools for modeling of protein segments into cryo-EM maps are sparse. Here, we present the FragFit web-application, a web server for interactive modeling of segments of up to 35 amino acids length into cryo-EM density maps. The fragments are provided by a regularly updated database containing at the moment about 1 billion entries extracted from PDB structures and can be readily integrated into a protein structure...
May 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29788260/impact-of-obesity-on-short-and-intermediate-term-outcomes-in-inflammatory-bowel-diseases-pooled-analysis-of-placebo-arms-of-infliximab-clinical-trials
#17
Siddharth Singh, James Proudfoot, Ronghui Xu, William J Sandborn
Background and aims: To assess whether obesity may affect natural history of inflammatory bowel diseases (IBD), we conducted an individual participant data (IPD) pooled analysis of placebo arms, using data from clinical trials of infliximab in IBD and using the Yale Open Data Access (YODA) Project. Methods: We obtained IPD from 4 placebo-controlled trials of infliximab in adults with IBD (ACCENT-I and ACCENT-II; ACT-1 and ACT-2). Patients were categorized into quartiles based on body mass index (BMI) or weight at time of trial entry...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787675/a-metal-stabilized-quinoidal-dibenzo-g-p-chrysene-fused-bis-dicarbacorrole-system
#18
Xian-Sheng Ke, Yongseok Hong, Vincent M Lynch, Dongho Kim, Jonathan L Sessler
We report here a metal complexation-based strategy that permits access to a highly stable expanded porphyrin-type quinoidal PAH. Specifically, double insertion of Pd(II) ions into a dibenzo[g,p]chrysene-fused bis-dicarbacorrole (bis-H3) gives rise to a bis-metalated species (bis-Pd) that undergoes a facile benzenoid-quinonoid transformation. In contrast to what is true for the corre-sponding mono-Pd(II) complex, which has organic radical character, well resolved 1H- and 19F NMR spectra are seen for bis-Pd. This complex is also electron paramagnetic resonance (EPR) silent over a range of temperatures...
May 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29787482/physical-performance-in-relation-to-menopause-status-and-physical-activity
#19
Dmitriy Bondarev, Eija K Laakkonen, Taija Finni, Katja Kokko, Urho M Kujala, Pauliina Aukee, Vuokko Kovanen, Sarianna Sipilä
OBJECTIVE: The aim of this study was to examine differences in physical performance (muscle power, muscle strength, aerobic capacity, and walking speed) across menopausal stages and potential of leisure physical activity (PA) to modify the impact of menopause on physical performance. METHODS: In this cross-sectional study, women aged 47 to 55 were randomly selected from the Finnish National Registry and categorized as premenopausal (n = 233), perimenopausal (n = 381), or postmenopausal (n = 299) based on serum concentrations of follicle-stimulating hormone and bleeding diary...
May 21, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29786848/annual-report-to-the-nation-on-the-status-of-cancer-part-i-national-cancer-statistics
#20
Kathleen A Cronin, Andrew J Lake, Susan Scott, Recinda L Sherman, Anne-Michelle Noone, Nadia Howlader, S Jane Henley, Robert N Anderson, Albert U Firth, Jiemin Ma, Betsy A Kohler, Ahmedin Jemal
BACKGROUND: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. METHODS: Incidence data were obtained from the CDC-funded and NCI-funded population-based cancer registry programs and compiled by NAACCR. Data on cancer deaths were obtained from the National Center for Health Statistics National Vital Statistics System...
May 22, 2018: Cancer
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