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Trachea stenosis

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https://www.readbyqxmd.com/read/27890997/complete-subglottic-tracheal-stenosis-managed-with-rigid-bronchoscopy-and-t-tube-placement
#1
Kuruswamy Thurai Prasad, Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh Nath Aggarwal, Ritesh Agarwal
Surgery is the preferred treatment modality for benign tracheal stenosis. Interventional bronchoscopy is used as a bridge to surgery or in instances when surgery is not feasible or has failed. Stenosis in the subglottic trachea is particularly a treatment challenge, in view of its proximity to the vocal cords. Herein, we describe a patient with complete tracheal stenosis in the subglottic region, which developed after prolonged intubation and mechanical ventilation. The patient developed recurrent stenosis despite multiple surgical and endoscopic procedures...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27885873/effects-of-artificial-tracheal-fixation-on-tracheal-epithelial-regeneration-and-prevention-of-tracheal-stenosis
#2
Yuta Nakaegawa, Ryosuke Nakamura, Yasuhiro Tada, Ryo Suzuki, Toshiaki Takezawa, Tatsuo Nakamura, Koichi Omori
CONCLUSION: Tight fixation of the artificial trachea is important for epithelialization and tracheal stenosis. OBJECTIVE: The authors have developed an artificial trachea and have used it for tracheal reconstruction. Although various studies on tracheal reconstruction have been conducted, no studies have examined the effect of artificial tracheal fixation on tracheal stenosis and regeneration. Therefore, the purpose of the present study was to evaluate the effect of artificial tracheal fixation...
November 25, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27882259/right-lung-agenesis-with-tracheal-stenosis-due-to-complete-tracheal-rings-and-postpneumonectomy-like-syndrome-treated-with-tissue-expander-placement
#3
Yashwant Agrawal, Sandeep Patri, Jagadeesh K Kalavakunta
Congenital lung agenesis is an extremely rare condition with an estimated prevalence of 34 in 1,000,000 live births. It is often associated with other congenital malformations of the skeletal, cardiovascular, urogenital, and gastrointestinal systems. We discuss the case of a 5-month-old who presented with increasing stridor over 1 month. Imaging revealed right lung agenesis, complete dextromalposition of heart, and compression of distal trachea. An intrathoracic saline tissue expander was placed which marked improved distal tracheal stenosis...
2016: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/27873304/stent-induced-tracheal-stenosis-can-be-predicted-by-il-8-expression-in-rabbits
#4
Elena Arellano-Orden, Carolina Serrano, Ana Montes-Worboys, Verónica Sánchez-López, Alicia Laborda, Fernando Lostalé, Celia Lahuerta, Francisco Rodríguez-Panadero, Miguel Ángel de Gregorio
BACKGROUND: Bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behavior of three commercially available stents in vivo (rabbits) and in vitro (co-culture of those stents with epithelial and fibroblast cell lines). Also, we investigated whether development of tracheal stenosis could be predicted by any biological marker. METHODS: The tracheae of 30 rabbits were implanted with either nitinol stents, with or without paclitaxel elution, or a cobalt-based stent...
November 22, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27863670/selection-and-fabrication-of-a-non-woven-polycarbonate-urethane-cover-for-a-tissue-engineered-airway-stent
#5
Weiluan Chen, Johanna Clauser, Anja Lena Thiebes, Donnacha J McGrath, Peter E McHugh, Ulrich Steinseifer, Stefan Jockenhoevel, Wim E Hennink, Robbert Jan Kok
One of the major problems in end-stage bronchotracheal cancer is stenosis of the upper airways, either due to luminal ingrowth of the tumor or mucus plugging. Airway stents that suppress tumor ingrowth and sustain mucociliary transport can alleviate these problems in end-stage bronchial cancer. We evaluated different types of polymeric covers for a tissue engineered airway stent. The distinguishing feature of this stent concept is that respiratory epithelial cells can grow on the luminal surface of the stent which facilitates mucociliary clearance...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27824004/paclitaxel-drug-eluting-tracheal-stent-could-reduce-granulation-tissue-formation-in-a-canine-model
#6
Ting Wang, Jie Zhang, Juan Wang, Ying-Hua Pei, Xiao-Jian Qiu, Yu-Ling Wang
BACKGROUND: Currently available silicone and metallic stents for tracheal stenosis are associated with many problems. Granulation proliferation is one of the main complications. The present study aimed to evaluate the efficacy of paclitaxel drug-eluting tracheal stent in reducing granulation tissue formation in a canine model, as well as the pharmacokinetic features and safety profiles of the coated drug. METHODS: Eight beagles were randomly divided into a control group (bare-metal stent group, n = 4) and an experimental group (paclitaxel-eluting stent group, n = 4)...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27774924/tracheal-t-tube-a-novel-endoscopic-insertion-technique
#7
A Nor Rahimah, F I Shahfi, M Masaany, N Gazali, S H Siti
BACKGROUND: Laryngotracheal stenosis is a complex condition of airway compromise involving either the larynx or trachea, or both. OBJECTIVES: This paper describes a new method of endoscopically inserting a silicone tracheal T-tube as treatment for laryngotracheal stenosis. The advantages of this method over previously described methods are discussed.
October 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27703342/chronic-pseudomonas-aeruginosa-infection-induced-chronic-bronchitis-and-emphysematous-changes-in-ccsp-deficient-mice
#8
Takemasa Matsumoto, Masaki Fujita, Ryosuke Hirano, Junji Uchino, Yukari Tajiri, Satoru Fukuyama, Yasuo Morimoto, Kentaro Watanabe
The club cell secretory protein (CCSP) is a regulator of lung inflammation following acute respiratory infection or lung injury. Recently, the relationship between CCSP and COPD has been reported. Since COPD results from an abnormal inflammatory response, we hypothesized that CCSP could have a protective role against chronic inflammation-induced lung damage. To address this issue, the pathophysiology of chronic lung inflammation induced by Pseudomonas aeruginosa in CCSP-deficient mice was determined. A tube of 5 mm in length was soaked in a fluid containing P...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27696422/rate-of-new-findings-in-diagnostic-office-bronchoscopy
#9
Liuba Soldatova, Brad W DeSilva, Laura A Matrka
OBJECTIVES: Awake Flexible Tracheobronchoscopy (FTB) is an alternative to rigid bronchoscopy or sedated flexible bronchoscopy and allows an awake examination of the tracheobronchial tree. We hypothesized that the ability to perform office bronchoscopy as the need arises during a clinic visit would lead to a high rate of previously undiagnosed and clinically relevant findings. This study reports the rate and nature of such findings for this procedure at our institution. STUDY DESIGN: Retrospective chart review...
October 3, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27670964/biodegradable-polydioxanone-stent-as-a-new-treatment-strategy-for-tracheal-stenosis-in-a-rabbit-model
#10
Insu Kawahara, Shigeru Ono, Kosaku Maeda
PURPOSE: Congenital tracheal stenosis (CTS) is a rare condition and difficult to treat. Slide tracheoplasty has unsatisfactory outcomes for severe neonatal symptomatic CTS. This study evaluated the use of biodegradable polydioxanone stents (BD stent) in a rabbit model of CTS. METHODS: Tracheal stenosis was induced in female Japanese white rabbits, 9-10weeks old, by direct scraping of the tracheal mucosa with a nylon brush following transverse incision of the trachea (control group, n=4)...
September 15, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27642166/critical-airway-obstruction-in-apparently-asymptomatic-neonates
#11
Benedict Griffiths, Geraint Lee, Andrew Durward
Central airway obstruction (trachea and major bronchi) in neonates can be caused by malacia, stenosis, or compression by masses or vascular structures. These abnormalities may be present in the neonatal period but are typically not detected until at least 6 months of age. We present four patients (1.6-4.1 kg, 32-41 weeks gestation) with nonspecific symptoms (e.g., poor weight gain, difficulty weaning from CPAP) who underwent bronchoscopy in the neonatal period. Critical airway obstruction (>90%) was identified in these relatively asymptomatic neonates...
September 18, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27641295/a-modified-technique-of-laryngotracheal-reconstruction-without-the-need-for-prolonged-postoperative-stenting
#12
Konrad Hoetzenecker, Thomas Schweiger, Imme Roesner, Matthias Leonhard, Gabriel Marta, Doris M Denk-Linnert, Berit Schneider-Stickler, Wolfgang Bigenzahn, Walter Klepetko
OBJECTIVES: Repair of laryngotracheal stenosis with pronounced side-to-side narrowing and involvement of the glottis is challenging and usually requires laryngotracheal reconstruction with rib cartilage interpositions. This technique, as first described by Couraud, needs prolonged postoperative stabilization with Montgomery T-tubes, imposing significant morbidity and discomfort on patients. We describe our initial experience with a modified laryngotracheal reconstruction technique that avoids the need for prolonged postoperative stenting...
October 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27621904/evaluation-of-airway-resistance-in-primary-small-cell-carcinoma-of-the-trachea-by-mostgraph-a-case-study
#13
Eri Hagiwara, Yasuhiro Gon, Kentaro Hayashi, Mai Takahashi, Yuko Iida, Hisato Hiranuma, Yoshiko Nakagawa, Tsukasa Hataoka, Kenji Mizumura, Shuichiro Maruoka, Tetsuo Shimizu, Noriaki Takahashi, Shu Hashimoto
The case subject was a 58-year-old woman who presented to our hospital with a chief complaint of respiratory discomfort. Wheezing could be heard in both lungs; treatment was initiated with inhaled steroids for suspected bronchial asthma. However, 1 week later, the respiratory discomfort had not improved and the wheezing sound had progressed to the neck area. Upper airway obstruction was suspected; therefore, chest computed tomography (CT) was performed, revealing tracheal stenosis caused by a tumor in the upper airway...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27619197/the-effects-of-curvature-and-constriction-on-airflow-and-energy-loss-in-pathological-tracheas
#14
A J Bates, R Cetto, D J Doorly, R C Schroter, N S Tolley, A Comerford
This paper considers factors that play a significant role in determining inspiratory pressure and energy losses in the human trachea. Previous characterisations of pathological geometry changes have focussed on relating airway constriction and subsequent pressure loss, however many pathologies that affect the trachea cause deviation, increased curvature, constriction or a combination of these. This study investigates the effects of these measures on tracheal flow mechanics, using compressive goitre (a thyroid gland enlargement) as an example...
September 9, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27594885/tracheobronchial-amyloidosis-mimicking-tracheal-tumor
#15
Elif Tanrıverdi, Mehmet Akif Özgül, Oğuz Uzun, Şule Gül, Mustafa Çörtük, Zehra Yaşar, Murat Acat, Naciye Arda, Erdoğan Çetinkaya
Tracheobronchial amyloidosis is a rare presentation and accounts for about 1% of benign tumors in this area. The diagnosis of disease is delayed due to nonspecific pulmonary symptoms. Therapeutic approaches are required to control progressive pulmonary symptoms for most of the patients. Herein, we report a case of a 68-year-old man admitted with progressive dyspnea to our institution for further evaluation and management. He was initially diagnosed with and underwent management for bronchial asthma for two years but had persistent symptoms despite optimal medical therapy...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27585358/metabolic-variations-in-normal-and-fibrotic-human-laryngotracheal-derived-fibroblasts-a-warburg-like-effect
#16
Garret Ma, Idris Samad, Kevin Motz, Linda X Yin, Madhavi V Duvvuri, Dacheng Ding, Daryan R Namba, Jennifer H Elisseeff, Maureen R Horton, Alexander T Hillel
OBJECTIVES/HYPOTHESIS: Laryngotracheal stenosis (LTS) is a chronic fibrotic disease characterized by fibroblast proliferation, collagen deposition, and matrix remodeling in the lamina propria of the larynx and/or trachea. Current medical therapies are limited by a poor understanding of the effector cell's (fibroblasts) cellular biology and metabolism. The purpose of this study was to compare cellular proliferation, function, and metabolism between normal and LTS-derived fibroblasts in vitro...
September 1, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27559721/diagnosis-of-subglottic-stenosis-in-a-rabbit-model-using-long-range-optical-coherence-tomography
#17
Olubunmi Ajose-Popoola, Erica Su, Ashley Hamamoto, Alex Wang, Joseph C Jing, Tony D Nguyen, Jason J Chen, Kathryn E Osann, Zhongping Chen, Gurpreet S Ahuja, Brian J F Wong
OBJECTIVES/HYPOTHESIS: Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. STUDY DESIGN: Prospective animal study in rabbits. METHODS: Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture...
August 25, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27520928/engineered-tissue-stent-biocomposites-as-tracheal-replacements
#18
Liping Zhao, Sumati Sundaram, Andrew V Le, Angela H Huang, Jiasheng Zhang, Go Hatachi, Arkadi Beloiartsev, Michael G Caty, Tai Yi, Katherine Leiby, Ashley Gard, Mehmet H Kural, Liqiong Gui, Kevin A Rocco, Amogh Sivarapatna, Elizabeth Calle, Allison Greaney, Luca Urbani, Panagiotis Maghsoudlou, Alan Burns, Paolo DeCoppi, Laura E Niklason
Here we report the creation of a novel tracheal construct in the form of an engineered, acellular tissue-stent biocomposite trachea (TSBT). Allogeneic or xenogeneic smooth muscle cells are cultured on polyglycolic acid polymer-metal stent scaffold leading to the formation of a tissue comprising cells, their deposited collagenous matrix, and the stent material. Thorough decellularization then produces a final acellular tubular construct. Engineered TSBTs were tested as end-to-end tracheal replacements in 11 rats and 3 nonhuman primates...
September 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27508127/an-innovative-operative-method-for-correction-of-tracheal-stenosis
#19
Dakshesh R Shah, Varsha Mungutwar
This is a case of failed attempt of hanging, resulted into cervical injury & injury to the trachea. Patient was put on the ventilator for respiratory support for long period. Poor recovery of the patient resulted into prolong tracheostomy tube. Combine effect of all resulted into suprastomal tracheal stenosis. Due to complexity of the problem a novel method was customized to correct the tracheal stenosis. Strap muscle (Sternohyoid & Sternothyroid) was raised as a flap; free cartilage was sandwiched in between and sutured to the created tracheal defect...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27500576/-the-low-invasive-treatment-of-laryngotrachealstenoses
#20
M Yu Ulupov
The objective of the present study was to evaluate the effectiveness and safety of balloonlaryngotracheoplasty for the treatment of laryngeal and tracheal stenosis We undertook the analysis of the case histories of the patients presenting withlaryngotracheal stenosis who had undergone balloonlaryngotracheoplasty during the period from October 2013 till February 2016. A total of 21 histories of the patients (6 men and 15 women) were available for the investigation. Most laryngotrachealstenoses that occurred in 18 (85...
2016: Vestnik Otorinolaringologii
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