Evan Clark, Edward Ryan R Talatala, Wenda Ye, Ruth J Davis, Samuel L Collins, Alexander T Hillel, Marisol Ramirez-Solano, Quanhu Sheng, Celestine N Wanjalla, Simon A Mallal, Alexander Gelbard
OBJECTIVES: Recent immunologic study of the adaptive immune repertoire in the subglottic airway demonstrated high-frequency T cell clones that do not overlap between individuals. However, the anatomic distribution and antigenic target of the T cell repertoire in the proximal airway mucosa remain unresolved. METHODS: Single-cell RNA sequencing of matched scar and unaffected mucosa from idiopathic subglottic stenosis patients (iSGS, n = 32) was performed and compared with airway mucosa from healthy controls (n = 10)...
March 7, 2024: Laryngoscope