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Trachea stenosis

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https://www.readbyqxmd.com/read/29779644/development-of-a-novel-tissue-engineered-nitinol-frame-artificial-trachea-with-native-like-physical-characteristics
#1
Yasuto Sakaguchi, Toshihiko Sato, Yusuke Muranishi, Yojiro Yutaka, Teruya Komatsu, Koichi Omori, Tatsuo Nakamura, Hiroshi Date
BACKGROUND: Tracheal reconstruction is complicated by the short length to which a trachea can be resected. We previously developed a biocompatible polypropylene frame artificial trachea, but it lacked the strength and flexibility of the native trachea. In contrast, nitinol may provide these physical characteristics. We developed a novel nitinol frame artificial trachea and examined its biocompatibility and safety in canine models. METHODS: We constructed several nitinol frame prototypes and selected the frame that most closely reproduced the strength of the native canine trachea...
April 24, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29756352/outcomes-after-cricotracheal-resection-for-idiopathic-subglottic-stenosis
#2
Patrick S Carpenter, Jenny L Pierce, Marshall E Smith
OBJECTIVES: Idiopathic subglottic stenosis (iSGS) is a rare disease in which patients develop airway narrowing and dyspnea from relapsing subglottic and tracheal granulation and scar tissue that narrows the airway. Definitive management has involved surgical resection and reconstruction of the subglottis and trachea. However, treatment options remain highly variable at different institutions. Here, we present our outcomes and experience after cricotracheal resection (CTR) for iSGS at a high-volume tertiary care center...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29756207/quantification-of-tissue-engineered-trachea-performance-with-computational-fluid-dynamics
#3
Lauren Eichaker, Chengyu Li, Nakesha King, Victoria Pepper, Cameron Best, Ekene Onwuka, Eric Heuer, Kai Zhao, Jonathan Grischkan, Christopher Breuer, Jed Johnson, Tendy Chiang
OBJECTIVES/HYPOTHESIS: Current techniques for airway characterization include endoscopic or radiographic measurements that produce static, two-dimensional descriptions. As pathology can be multilevel, irregularly shaped, and dynamic, minimal luminal area (MLA) may not provide the most comprehensive description or diagnostic metric. Our aim was to examine the utilization of computational fluid dynamics (CFD) for the purpose of defining airway stenosis using an ovine model of tissue-engineered tracheal graft (TETG) implantation...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29747054/a-modification-of-the-bjork-flap-in-tracheostomies-for-head-and-neck-cancer-patients
#4
Panagiotis Stathopoulos, Leo Stassen
The etymology of the word tracheotomy derives from two Ancient Greek words: the word trachea (Greek τραχɛία tracheía) and the word stoma (Greek στóμα stóma) meaning "mouth," and refers to the making of an opening. It is believed that an early tracheostomy was performed by the Greek physician Asclepiades of Bithynia, in order to treat upper airway obstruction. A secure airway in the intraoperative and early postoperative period is of paramount importance for a number patients undergoing head and neck cancer surgery...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29742573/cervical-tracheal-resection-and-anastomosis-for-postintubation-tracheal-stenosis
#5
Muzaffer Kanlikama, Fatih Celenk, Burhanettin Gonuldas, Secaattin Gulsen
In this study the authors evaluated the outcomes of tracheal resection and anastomosis in postintubation tracheal stenosis. The authors also aimed to identify clinical and radiological factors associated with restenosis. Thirty-four consecutive patients were included in the study. Patients with subglottic stenosis who underwent procedures involving cricoid cartilage and patients with other etiologies were excluded from the study. Univariate analysis was performed to determine the risk factors for restenosis...
May 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29707509/idiopathic-subglottic-stenosis-techniques-and-results
#6
REVIEW
Andrea L Axtell, Douglas J Mathisen
Idiopathic subglottic stenosis is a rare condition of unknown etiology characterized by circumferential stenosis in the subglottic larynx and upper trachea. Historically, patients were treated with dilation or ablation, however this approach has proven to be largely palliative and often leads to recurrence and the need for tracheostomy. A single-staged laryngotracheal resection and reconstruction is now the preferred definitive treatment for idiopathic subglottic stenosis and can be performed with excellent patient outcomes and rare subsequent progression of the disease...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29607202/impact-of-3d-printing-on-the-surgical-management-of-tracheal-stenosis-associated-to-pulmonary-sling-a-case-report
#7
Luigi Arcieri, Raffaele Giordano, Ermanno Bellanti, Dante Chiappino, Bruno Murzi
Congenital tracheal stenosis (CTS) is rare lesions frequently associated with pulmonary sling (PS). Despite the recent improvement in the results by the introduction of slide tracheoplasty (ST) and multidisciplinary approach, surgical management remains difficult and several authors, for this reason, debate for a conservative approach in these cases. Preoperative planning, require hence the use of the most innovative technology to gain the best possible result. This report describes a complicated, unsuccessful surgically treated case of CTS associated to PS...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29605358/surgical-management-of-children-presenting-with-surgical-needed-tracheal-stenosis
#8
Marie-Eva Rossi, Eric Moreddu, Loïc Macé, Jean-Michel Triglia, Richard Nicollas
OBJECTIVES: The purpose of this work was to assess epidemiological aspects, surgical approach, morbidity and mortality rates of patients presenting with tracheal stenosis requiring surgery, and the evolution of surgical techniques over the last years. METHODS: We performed a retrospective observational study from 1990 to 2017 in a pediatric tertiary-care center with needing surgery for tracheal stenosis. We analyzed clinical patients' characteristics, type of stenosis, type of surgery and follow-up...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29580173/reinforced-electrospun-polycaprolactone-nanofibers-for-tracheal-repair-in-an-in-vivo-ovine-model
#9
Jakob M Townsend, Lindsey M Ott, Jean R Salash, Kar-Ming Fung, Jeremiah T Easley, Howard B Seim, Jed Johnson, Robert A Weatherly, Michael Scott Detamore
Tracheal stenosis caused by congenital anomalies, tumors, trauma, or intubation-related damage can cause severe breathing issues, diminishing the quality of life, and potentially becoming fatal. Current treatment methods include laryngotracheal reconstruction or slide tracheoplasty. Laryngotracheal reconstruction utilizes rib cartilage harvested from the patient, requiring a second surgical site. Slide tracheoplasty involves a complex surgical procedure to splay open the trachea and reconnect both segments to widen the lumen...
March 27, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29489542/long-segment-tracheal-reconstruction-with-free-radial-forearm-flap-reinforced-by-rib-cartilage
#10
Céline Thomet, Ali Modarressi, Eva Meia Rüegg, Pavel Dulguerov, Brigitte Pittet-Cuénod
Long-segment tracheal reconstruction remains a challenge. The ideal tracheal substitute should be an epithelialized tube to prevent stenosis and sufficiently rigid to maintain airflow patency. An autologous technique using a radial forearm free flap reinforced by rib cartilage has been recently described for tracheal reconstruction. We report here two cases of complex tracheal reconstruction with a modification of this technique, which consists of the creation of two independent skin paddles to allow the reconstruction of the trachea and a second adjacent defect (eg, cervical skin, esophagus)...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29484049/delayed-recurrence-of-ulcerative-colitis-manifested-by-tracheobronchitis-bronchiolitis-and-bronchiolectasis
#11
Iclal Ocak, Gideon Bollino, Carl Fuhrman
Ulcerative colitis can cause inflammation of small and large airways, characterized by mucosal inflammation, tracheobronchial stenosis, bronchiestasis, and bronchiolitis. We present a case of tracheobronchitis and bronchiolitis associated with ulcerative colitis in a 58-year-old nonsmoking man, 17 years after the total colectomy and complete resolution of intestinal findings. Computed tomography demonstrated wall thickening of trachea and left main stem bronchus, and multiple bronchi around the both hilum with mild to moderate stenosis...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29447825/profilactic-role-of-simvastatin-and-mitomycin-c-in-tracheal-stenosis-after-tracheal-damage-study-in-rats
#12
Adnan Ekinci, Sema Koc, Ahmet Serhat Erdoğan, Hakan Kesici
OBJECTIVES: We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment. Randomized prospective single-blind. MATERIAL AND METHOD: Standard vertical tracheotomy was performed on 24 rats. Then the animals were randomly divided into three groups as A, B and C. In group A 0.4 mg/day once daily mitomycin C was injected to the paratracheal region for 14 days...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29429553/intubation-in-two-patients-with-difficult-airway-management-and-tracheal-stenosis-after-tracheostomy-in-thoracic-surgery
#13
M Granell Gil, P Solís Albamonte, C Córdova Hernández, I Cobo, R Guijarro, J A de Andrés Ibañez
Lung isolation in thoracic surgery is a challenge, this is even more complex in the presence of unknown tracheal stenosis (TS). We report two cases of unknown TS and its airway management. TS appears most frequently after long term intubation close to the endotracheal tube cuff or in the stoma of tracheostomy that appears as a consequence of the granulation tissue after the surgical opening of the trachea. Clinical history, physical examination, difficult intubating predictors and imaging tests (CT scans) are crucial, however most of tracheal stenosis may be unnoticed and symptoms depend on the degree of obstruction...
February 8, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29428562/notum-attenuates-wnt-%C3%AE-catenin-signaling-to-promote-tracheal-cartilage-patterning
#14
Bradley Gerhardt, Lauren Leesman, Kaulini Burra, John Snowball, Rachel Rosenzweig, Natalie Guzman, Manoj Ambalavanan, Debora Sinner
Tracheobronchomalacia (TBM) is a common congenital disorder in which the cartilaginous rings of the trachea are weakened or missing. Despite the high prevalence and clinical issues associated with TBM, the etiology is largely unknown. Our previous studies demonstrated that Wntless (Wls) and its associated Wnt pathways are critical for patterning of the upper airways. Deletion of Wls in respiratory endoderm caused TBM and ectopic trachealis muscle. To understand mechanisms by which Wls mediates tracheal patterning, we performed RNA sequencing in prechondrogenic tracheal tissue of Wlsf/f ;ShhCre/wt embryos...
April 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29415198/extended-surgery-using-anterior-mediastinal-tracheostomy-for-recurrent-mediastinal-liposarcoma
#15
Masaru Takenaka, Yoshinobu Ichiki, Akihiro Taira, Fumihiro Tanaka
Mediastinal liposarcoma is an extremely rare malignancy with a poor prognosis. We report the case of a 73-year-old man who presented with severe respiratory distress. He had previously been diagnosed with mediastinal liposarcoma, which had been treated with extirpation 6 years ago. The histological type was a well-differentiated liposarcoma. Three years ago, he experienced respiratory distress due to postoperative recurrence of mediastinal liposarcoma. To establish an airway, tracheotomy was urgently performed...
February 3, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29413285/normal-tissue-complication-probability-modeling-of-pulmonary-toxicity-after-stereotactic-and-hypofractionated-radiation-therapy-for-central-lung-tumors
#16
H Tekatli, M Duijm, E Oomen-de Hoop, W Verbakel, W Schillemans, B J Slotman, J J Nuyttens, S Senan
PURPOSE: To evaluate clinical pulmonary and radiographic bronchial toxicity after stereotactic ablative radiation therapy and hypofractionated radiation therapy for central lung tumors, and perform normal tissue complication probability modeling and multivariable analyses to identify predictors for toxicity. METHODS AND MATERIALS: A pooled analysis was performed of patients with a central lung tumor treated using ≤12 fractions at 2 centers between 2006 and 2015...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29397926/bronchial-mismatch-as-a-predictor-of-respiratory-failure-after-congenital-tracheal-stenosis-repair
#17
Enrico Cetrano, Matteo Trezzi, Aurelio Secinaro, Luca Di Chiara, Marilena Trozzi, Sergio Bottero, Angelo Polito, Adriano Carotti
BACKGROUND: The purpose of this study was to identify predictors of postoperative respiratory failure after surgical tracheoplasty for congenital tracheal stenosis. METHODS: Between February 2011 and April 2017, 16 infants underwent congenital tracheal stenosis repair. Preoperative computed tomography evaluation of the trachea and mainstem bronchi was performed. The primary outcome was midterm freedom from postoperative respiratory failure defined as persistent need for mechanical ventilation or surgical tracheobronchial reoperation...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29379233/radiological-spectrum-of-anthracofibrosis-a-series-of-40-patients-with-computed-tomography-bronchoscopy-and-biopsy
#18
Anandamoyee Dhar, Kunal Sikund, Ajal Lall, Bharat Aggarwal
Introduction: Anthracofibrosis is a lesser known clinical entity. Patients present with chronic symptoms of cough and breathlessness with a history of biofuel/wood fire smoke exposure. There are distinct computed tomography (CT) imaging features of anthracofibrosis that can differentiate it from more common conditions such as tuberculosis (TB) and bronchogenic carcinoma. Findings include multifocal noncontiguous stenosis of bronchial tree, calcified enlarged mediastinal or hilar nodes, and secondary lung parenchymal changes...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29367358/recurrent-migration-of-peripherally-inserted-central-catheter-into-the-azygos-vein
#19
Goutham Talari, Preetham Talari, Saurabh Parasramka, Aibek E Mirrakhimov
Peripherally inserted central catheter (PICC) migration into azygos vein (AV) is a rare complication. It is recognised only when catheter malfunction occurs or when patients develop associated complications. PICC migration into AV has been reported to be associated with various complications such as catheter malfunction, perforation, haemorrhage, thrombosis, infection and stenosis of AV. Pleural effusion and trachea-azygos fistulas have also been reported. We present a patient with recurrent migration of PICC into AV after an initial corrective repositioning during the same hospital stay...
January 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29365389/-advances-in-tracheal-transplantation
#20
P C Cui
The length of tracheal defect or stenosis exceeded 5 cm could not be treated by simple resection and end-to-end anastomosis of the remaining trachea. Various ways of tracheal replacement had appeared sequentially, such as radial forearm free flap with cartilage grafts, tracheal tissue-engineering and tracheal allotransplantation. Among these methods, tracheal allotransplantation displayed a better long-term result. In this review, we are focused on recent advances in tracheal allotransplantation, particularly on revascularization and reepithelialization of graft, as well as on the application of immunosuppressive agents...
January 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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