Elisabeth M L de Wijkerslooth, Evert-Jan G Boerma, Charles C van Rossem, Joost van Rosmalen, Coen I M Baeten, Frédérique H Beverdam, Johanna W A M Bosmans, Esther C J Consten, Jan Willem T Dekker, Marloes Emous, Anna A W van Geloven, Anton F Gijsen, Luc A Heijnen, An P Jairam, Damian C Melles, Augustinus P T van der Ploeg, Pascal Steenvoorde, Boudewijn R Toorenvliet, Maarten Vermaas, Bas Wiering, Bas P L Wijnhoven, Anne Loes van den Boom
BACKGROUND: The appropriate duration of postoperative antibiotics for complex appendicitis is unclear. The increasing global threat of antimicrobial resistance warrants restrictive antibiotic use, which could also reduce side-effects, length of hospital stay, and costs. METHODS: In this pragmatic, open-label, non-inferiority trial in 15 hospitals in the Netherlands, patients with complex appendicitis (aged ≥8 years) were randomly assigned (1:1) to receive 2 days or 5 days of intravenous antibiotics after appendicectomy...
February 4, 2023: Lancet