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https://www.readbyqxmd.com/read/27922142/prevalence-and-risk-factors-of-caregiver-dependence-among-older-adults-in-a-southeast-asian-population
#1
Louisa Picco, Edimansyah Abdin, Janhavi A Vaingankar, Shirlene Pang, Saleha Shafie, Rajeswari Sambasivam, Siow Ann Chong, Mythily Subramaniam
INTRODUCTION: Currently very little is known about the prevalence or magnitude of caregiver dependence in Singapore and thus, there is a need to fill this gap in this multiethnic ageing population. This study aims to determine the prevalence and risk factors of caregiver dependence among older adults in Singapore. MATERIALS AND METHODS: Data were used from the Well-being of the Singapore Elderly (WiSE) study, a nationally representative, cross-sectional survey among Singapore residents aged 60 years and above...
November 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27920478/diabetes-mellitus-may-affect-the-long-term-survival-of-hepatitis-b-virus-related-hepatocellular-carcinoma-patients-after-liver-transplantation
#2
Qing Zhang, Yong-Lin Deng, Chang Liu, Li-Hong Huang, Lei Shang, Xin-Guo Chen, Le-Tian Wang, Jin-Zan Du, Ying Wang, Pei-Xiao Wang, Hui Zhang, Zhong-Yang Shen
AIM: To determine whether diabetes mellitus (DM) affects prognosis/recurrence after liver transplantation (LT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study was conducted between January 2000 and August 2013 on 1631 patients with HBV-related HCC who underwent LT with antiviral prophylaxis. Patient data were obtained from the China Liver Transplant Registry (https://www.cltr.org/). To compare the outcomes and tumor recurrence in the HBV-related HCC patients with or without DM, statistical analyses were conducted using χ(2) tests, Mann-Whitney tests, the Kaplan-Meier method, log-rank tests and multivariate step-wise Cox regression analysis...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27919906/individual-care-plans-reduce-falls-and-broken-hips-in-new-zealand-hospitals
#3
Jacqui Wise
No abstract text is available yet for this article.
December 4, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27919427/-lose-the-tube-a-choosing-wisely-initiative-to-reduce-catheter-associated-urinary-tract-infections-in-hospitalist-led-inpatient-units
#4
Hyung J Cho, Steve Khalil, Jashvant Poeran, Madhu Mazumdar, Nathaniel Bravo, Fran Wallach, Brian Markoff, Nathan Lee, Andrew S Dunn
We developed a multidisciplinary initiative, "Lose the Tube," focused on a Choosing Wisely recommendation to decrease catheter-associated urinary tract infection (CAUTI) rates and catheter days. Through an electronic health record catheter identification tool, daily interdisciplinary query, and clinician education, our multifaceted intervention reduced mean per-person catheter days from 3.3 to 2.9, decreased CAUTI rates from 2.85 to 0.32 per 1,000 catheter days, and reduced cost by $32,245.
December 2, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27919404/individualized-metacognitive-therapy-for-delusions-a-randomized-controlled-rater-blind-study
#5
Christina Andreou, Charlotte E Wittekind, Martina Fieker, Ulrike Heitz, Ruth Veckenstedt, Francesca Bohn, Steffen Moritz
BACKGROUND: Theory-driven interventions targeting specific factors that contribute to delusions are receiving increased interest. The present study aimed to assess the efficacy of individualized metacognitive therapy (MCT+), a short manualized intervention that addresses delusion-associated cognitive biases. METHODS: 92 patients with current or past delusions were randomized to receive 12 twice-weekly sessions of either MCT+ or a control intervention within a randomized controlled rater-blind design...
November 29, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27918912/predicting-cyp2d6-phenotype-from-resting-brain-perfusion-images-by-gradient-boosting
#6
Giulio Napolitano, Julia C Stingl, Matthias Schmid, Roberto Viviani
The cytochrome P450 enzyme 2D6 is involved in the metabolism of 20% of all commonly used drugs, including many psychotropic drugs and CNS-active substances. CYP2D6 is among the CYP enzymes with the highest expression levels in the brain, suggesting a role in the local brain metabolism of psychotropic drugs and the existence of endogenous substrates. The genetic polymorphism of CYP2D6, which causes individual differences in activity levels of the enzyme, has also been characterized functionally in human brain imaging studies...
November 22, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918351/pediatric-oncology-discharges-with-febrile-neutropenia-variation-in-location-of-care
#7
Elysia Alvarez, Lisa J Chamberlain, Catherine Aftandilian, Olga Saynina, Paul Wise
We examined the use of Pediatric Cancer Specialty Centers (PCSCs) over time and the length of stay (LOS) in pediatric oncology patients with a diagnosis of febrile neutropenia. PCSCs were defined as Children's Oncology Group and California Children's Services designated centers. We performed a retrospective analysis on all discharges of pediatric (0 to 18) oncology patients with febrile neutropenia in California (1983 to 2011) using the private Office of Statewide Health Planning and Development database. We examined influence of age, sex, race/ethnicity, payer, income, distance, tumor type, and complications on utilization of PCSCs and LOS (SAS 9...
December 1, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27917752/genetic-and-environmental-factors-in-invasive-cervical-cancer-design-and-methods-of-a-classical-twin-study
#8
Dorothy A Machalek, John D Wark, Sepehr N Tabrizi, John L Hopper, Minh Bui, Gillian S Dite, Alyssa M Cornall, Marian Pitts, Dorota Gertig, Bircan Erbas, Suzanne M Garland
BACKGROUND: Persistent high-risk human papillomavirus (HPV) infection is a necessary prerequisite for development of cervical cancer and its precursor lesion, high-grade squamous intraepithelial lesion (HSIL). However, HPV infection is not sufficient to drive this process, and genetic and environmental factors may also play a role. METHODS/DESIGN: The Cervical Cancer, Genetics and Environment Twin Study was established to investigate the environmental and genetic influences on variation in susceptibility to cervical pre-cancer in 25- to 69-year-old monozygotic (MZ) and dizygotic (DZ) twins recruited through the Australian Twin Registry...
December 5, 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/27917679/the-default-mode-network-in-healthy-individuals-a-systematic-review-and-meta-analysis
#9
Lauren Elizabeth Mak, Luciano Minuzzi, Glenda MacQueen, Geoffrey Hall, Sidney Kennedy, Roumen Milev
OBJECTIVE: When the brain is not engaged in goal-directed activities and at "rest", there are still measureable patterns of activity. One resting state network, the default mode network (DMN) is responsible for a self-referential introspective state. There are many factors that influence normal changes in brain activity. The purpose of this review is to summarize differences in DMN functional connectivity in healthy individuals by age, sex, cognitive function and analysis type to characterize what is "normal"...
December 4, 2016: Brain Connectivity
https://www.readbyqxmd.com/read/27917569/distinct-intrinsic-functional-brain-network-abnormalities-in-methamphetamine-dependent-patients-with-and-without-a-history-of-psychosis
#10
Jonathan C Ipser, Anne Uhlmann, Paul Taylor, Brian H Harvey, Don Wilson, Dan J Stein
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP)...
December 5, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27917260/integrative-bayesian-analysis-of-neuroimaging-genetic-data-through-hierarchical-dimension-reduction
#11
S Azadeh, B P Hobbs, L Ma, D A Nielsen, F G Moeller, V Baladandayuthapani
Advances in neuromedicine have emerged from endeavors to elucidate the distinct genetic factors that influence the changes in brain structure that underlie various neurological conditions. We present a framework for examining the extent to which genetic factors impact imaging phenotypes described by voxel-wise measurements organized into collections of functionally relevant regions of interest (ROIs) that span the entire brain. Statistically, the integration of neuroimaging and genetic data is challenging. Because genetic variants are expected to impact different regions of the brain, an appropriate method of inference must simultaneously account for spatial dependence and model uncertainty...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/27916816/blueberry-consumption-affects-serum-uric-acid-concentrations-in-older-adults-in-a-sex-specific-manner
#12
Carol L Cheatham, Itzel Vazquez-Vidal, Amanda Medlin, V Saroja Voruganti
Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65-80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment...
November 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27916710/aberrant-regional-homogeneity-in-parkinson-s-disease-a-voxel-wise-meta-analysis-of-resting-state-functional-magnetic-resonance-imaging-studies
#13
REVIEW
PingLei Pan, Hui Zhan, MingXu Xia, Yang Zhang, DeNing Guan, Yun Xu
Studies of abnormal regional homogeneity (ReHo) in Parkinson's disease (PD) have reported inconsistent results. Therefore, we conducted a meta-analysis using the Seed-based d Mapping software package to identify the most consistent and replicable findings. A systematic literature search was performed to identify eligible whole-brain resting-state functional magnetic resonance imaging studies that had measured differences in ReHo between patients with PD and healthy controls between January 2000 and June 4, 2016...
December 1, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27915119/neural-correlates-of-pupil-dilation-during-human-fear-learning
#14
Laura Leuchs, Max Schneider, Michael Czisch, Victor I Spoormaker
BACKGROUND: Fear conditioning and extinction are prevailing experimental and etiological models for normal and pathological anxiety. Pupil dilations in response to conditioned stimuli are increasingly used as a robust psychophysiological readout of fear learning, but their neural correlates remain unknown. We aimed at identifying the neural correlates of pupil responses to threat and safety cues during a fear learning task. METHODS: Thirty-four healthy subjects underwent a fear conditioning and extinction paradigm with simultaneous functional magnetic resonance imaging (fMRI) and pupillometry...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27914775/assessment-of-background-gamma-radiation-levels-using-airborne-gamma-ray-spectrometer-data-over-uranium-deposits-cuddapah-basin-india-a-comparative-study-of-dose-rates-estimated-by-agrs-and-pgrs
#15
D Srinivas, V Ramesh Babu, I Patra, Shailesh Tripathi, M S Ramayya, A K Chaturvedi
The Atomic Minerals Directorate for Exploration and Research (AMD) has conducted high-resolution airborne gamma ray spectrometer (AGRS), magnetometer and time domain electromagnetic (TDEM) surveys for uranium exploration, along the northern margins of Cuddapah Basin. The survey area includes well known uranium deposits such as Lambapur-Peddagattu, Chitrial and Koppunuru. The AGRS data collected for uranium exploration is utilised for estimating the average absorbed rates in air due to radio-elemental (potassium in %, uranium and thorium in ppm) distribution over these known deposit areas...
November 30, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27914693/high-prevalence-of-osteoporosis-and-morphometric-vertebral-fractures-in-indian-males-aged-60-years-and-above-should-age-for-screening-be-lowered
#16
Khurshid A Bhat, Manisha Kakaji, Ashish Awasthi, Manoj Shukla, Manoj Dubey, Rajesh Srivastava, Uttam Singh, Sushil K Gupta
Current guidelines recommend bone mineral density (BMD) measurement in asymptomatic men above age 70 years and vertebral fracture (VF) assessment above 80 years with T-score <-1.0 with risk factors. We studied the prevalence of osteoporosis and morphometric VF in asymptomatic males aged 60 years and above in North India. Free-living community-dwelling men (n = 241, age: mean ± standard deviation 68.0 ± 6.2 years) underwent a detailed history, physical examination, biochemical evaluation, and BMD measurements at 3 sites: lumbar spine, total hip (TH), and femoral neck (FN)...
November 30, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27914333/nano-zinc-oxide-incorporated-graphene-oxide-nanocellulose-composite-for-the-adsorption-and-photo-catalytic-degradation-of-ciprofloxacin-hydrochloride-from-aqueous-solutions
#17
T S Anirudhan, J R Deepa
Purpose of this study is to report the synthetic procedure of a novel photo catalyst, nano zinc oxide incorporated graphene oxide/nanocellulose (ZnO-GO/NC) for the effective adsorption and subsequent photo degradation of ciprofloxacin (CF), an antibiotic widely used in the poultry. Self cleaning property in cellulose was achieved by introducing a nano zinc oxide incorporated graphene oxide into nanocellulose (NC) matrix. By incorporating nano zinc oxide (ZnO) in graphene oxide (GO), band gap could be tuned to 2...
November 17, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27913827/intra-lesional-spatial-correlation-of-static-and-dynamic-fet-pet-parameters-with-mri-based-cerebral-blood-volume-in-patients-with-untreated-glioma
#18
Jens Göttler, Mathias Lukas, Anne Kluge, Stephan Kaczmarz, Jens Gempt, Florian Ringel, Mona Mustafa, Bernhard Meyer, Claus Zimmer, Markus Schwaiger, Stefan Förster, Christine Preibisch, Thomas Pyka
PURPOSE: (18)F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak static FET-uptake and rCBV have been reported. Herein, we assess the local intra-lesional relation between FET-PET parameters and rCBV. METHODS: Thirty untreated glioma patients (27 high-grade) underwent simultaneous PET/MRI on a 3 T hybrid scanner obtaining structural and dynamic susceptibility contrast sequences...
December 2, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27913455/inherited-thrombophilia-a-double-edged-sword
#19
Saskia Middeldorp
Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not guide treatment decisions, not testing patients with VTE for inherited thrombophilia is on the "Choosing Wisely" list endorsed by multiple specialty societies, including ASH...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913449/nice-advises-routine-high-sensitivity-troponin-tests-to-rule-out-mi
#20
Jacqui Wise
No abstract text is available yet for this article.
December 1, 2016: BMJ: British Medical Journal
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