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Marco Giardiello, Neill J Liptrott, Tom O McDonald, Darren Moss, Marco Siccardi, Phil Martin, Darren Smith, Rohan Gurjar, Steve P Rannard, Andrew Owen
Considerable scope exists to vary the physical and chemical properties of nanoparticles, with subsequent impact on biological interactions; however, no accelerated process to access large nanoparticle material space is currently available, hampering the development of new nanomedicines. In particular, no clinically available nanotherapies exist for HIV populations and conventional paediatric HIV medicines are poorly available; one current paediatric formulation utilizes high ethanol concentrations to solubilize lopinavir, a poorly soluble antiretroviral...
October 21, 2016: Nature Communications
Phil Skolnick, Nora D Volkow
Limited options for treating moderate-severe pain led to an overreliance on opioids and the current opioid epidemic. Addressing the factors contributing to a dearth of effective alternatives and re-energizing the development of pain therapeutics is necessary to quell this epidemic.
October 19, 2016: Neuron
Yoonsik Shim, Andrew Philippides, Kevin Staras, Phil Husbands
We propose a biologically plausible architecture for unsupervised ensemble learning in a population of spiking neural network classifiers. A mixture of experts type organisation is shown to be effective, with the individual classifier outputs combined via a gating network whose operation is driven by input timing dependent plasticity (ITDP). The ITDP gating mechanism is based on recent experimental findings. An abstract, analytically tractable model of the ITDP driven ensemble architecture is derived from a logical model based on the probabilities of neural firing events...
October 2016: PLoS Computational Biology
Richard Laugharne, Matt Branch, Anji Mitchell, Lindsay Parkin, Phil Confue, Rohit Shankar, Diane Wilson-James, Mike Marshall, Maria Edgecombe, Bernie Keaney, Kiran Gill, Juliet Harrison
OBJECTIVE: The sudden closure of 30 out of 54 acute psychiatric beds in Cornwall presented a stressful challenge to staff but also a natural experiment on how a service dealt with this situation. We aimed to evaluate the outcomes of patients needing to leave the closed ward, how bed occupancy rates were affected and the impact on admission rates. DESIGN: A service evaluation of the impact of the ward closure. SETTING: A comprehensive secondary NHS mental health service in Cornwall serving 550,000 population...
October 2016: JRSM Open
Dean Picone, Martin Schultz, Petr Otahal, J Andrew Black, Nathan Dwyer, Alun Hughes, Fuyou Liang, Ronak Rajani, Phil Roberts-Thomson, Velandai Srikanth, Kenji Takazawa, James Sharman
OBJECTIVE: Accurate measurement of blood pressure (BP) is crucial for hypertension management. Accuracy of brachial cuff (BCUFF) devices to measure invasive (intra-arterial) BP at the brachial artery (BINV) and aorta (AINV) has never been systematically assessed. This study aimed to determine the: 1) relationship between BINV and AINV; 2) accuracy of BCUFF devices to estimate invasive BP and; 3) accuracy of BCUFF devices to classify BP thresholds. DESIGN AND METHOD: Three individual patient meta-analyses (by search of online databases and systematic review supplemented by measurements in a tertiary hospital cardiac catheterization laboratory) were performed to determine: 1) BINV versus AINV BP; 2) BCUFF versus BINV BP and AINV BP and; 3) BCUFF for BP classification versus invasive BP...
September 2016: Journal of Hypertension
Carla C Baan
Over 3000 delegates attended the 26st International Congress of the Transplantation Society in Hong Kong, which marked the 50th anniversary of the society. In his presidential address, Professor Phil O'Connell from the Westmead Hospital in Sydney, Australia, commented that a major challenge for the future is improving long-term outcomes after solid organ transplantation. He highlighted that 40% of transplanted organs are lost within 10 years, and that a high proportion of patients suffer from immunosuppression-related side effects...
October 7, 2016: Transplantation
Peter Hoffmann, Lori Martin, Michael Keselica, Diane Gunson, Elizabeth Skuba, Dan Lapadula, Michael Hayes, Phil Bentley, Steve Busch
This article describes acute toxicity data in cynomolgus monkeys following oral treatment with vildagliptin, a dipeptidyl peptidase-4 inhibitor. Acute toxicity symptoms in cynomolgus monkeys include edema formation of the extremities, tails, and face associated with skeletal muscle necrosis, and elevations of lactate dehydrogenase, creatine kinase, alanine transaminase, and aspartate aminotransferase activities in the serum; hypothermia; hypotension; tachycardia; moribundity; and death in a few isolated instances...
October 17, 2016: Toxicologic Pathology
Hyuk Jun Yang, Gi Woon Kim, Gyu Chong Cho, Yang Ju Tak, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Ai-Rhan Ellen Kim, Han Suk Kim, Su Jin Cho, Yong Sung Choi, Eun Sun Kim, Hye Won Park, Yong Hoon Cheon, Moon Sung Park, Yoon Sil Chang, Young Han Kim, Dong Yeon Kim, Hee Jo Yoon, Yeon Hee Kim, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Do Kyun Kim, Won Kyoung Jhang, Ji Yun Ahn, Ji Sook Lee, Yoon Hee Kim, Bongjin Lee, Gi Beom Kim, Jin-Tae Kim, June Huh, June Dong Park, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Ji Sook Lee, Ji Yun Ahn, Do Kyun Kim, Yoon Hee Kim, Bongjin Lee, Won Kyoung Jhang, Gi Beom Kim, Jin-Tae Kim, June Huh, June Dong Park, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Young-Min Kim, Kyu Nam Park, Seung Pill Choi, Byung Kook Lee, Kyungil Park, Jeongmin Kim, Ji Hoon Kim, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Mi Jin Lee, Tai Ho Rho, Hyun Kim, Gu Hyun Kang, June Soo Kim, Sang Gyun Rho, Hyun Kyung Park, Dong Jin Oh, Seil Oh, Jin Wi, Sangmo Je, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Keun Jeong Song, Jae-Bum Kim, Jinhee Kim, Chanwoong Kim, Sun Young Park, Chang Hee Lee, Yong Soo Jang, Gyu Chong Cho, Youngsuk Cho, Sung Phil Chung, Sung Oh Hwang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Sung Oh Hwang, Sung Phil Chung, Keun Jeong Song, Hyun Kim, Tae Ho Rho, Kyu Nam Park, Young-Min Kim, June Dong Park, Ai-Rhan Ellen Kim, Hyuk Jun Yang
No abstract text is available yet for this article.
July 2016: Clin Exp Emerg Med
Nina Smyth, Lisa Thorn, Frank Hucklebridge, Angela Clow, Phil Evans
The cortisol awakening response (CAR) is typically measured in the domestic setting. Moderate sample timing inaccuracy has been shown to result in erroneous CAR estimates and such inaccuracy has been shown partially to explain inconsistency in the CAR literature. The need for more reliable measurement of the CAR has recently been highlighted in expert consensus guidelines where it was pointed out that less than 6% of published studies provided electronic-monitoring of saliva sampling time in the post-awakening period...
September 30, 2016: Psychoneuroendocrinology
Jae-Phil Shim, Won-Seok Seong, Jung-Hong Min, Duk-Jo Kong, Dong-Ju Seo, Hyung-Jun Kim, Dong-Seon Lee
We introduce ITO on graphene as a current-spreading layer for separated InGaN/GaN nanorod LEDs for the purpose of passivation-free and high light-extraction efficiency. Transferred graphene on InGaN/GaN nanorods effectively blocks the diffusion of ITO atoms to nanorods, facilitating the production of transparent ITO/graphene contact on parallel-nanorod LEDs, without filling the air gaps, like a bridge structure. The ITO/graphene layer sufficiently spreads current in a lateral direction, resulting in uniform and reliable light emission observed from the whole area of the top surface...
October 17, 2016: Nanotechnology
Maoqun Tian, Ming Yan, Phil S Baran
A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed and their absolute configuration has been assigned. The dense array of functionality, high polarity, and rich stereochemistry coupled with equilibrating topologies present an unusual challenge for chemical synthesis and an opportunity for innovation. Key steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H functionalization, and a surprisingly simple final step that intersects a presumed biosynthetic intermediate...
October 17, 2016: Journal of the American Chemical Society
Alex Graves, Greg Wayne, Malcolm Reynolds, Tim Harley, Ivo Danihelka, Agnieszka Grabska-Barwińska, Sergio Gómez Colmenarejo, Edward Grefenstette, Tiago Ramalho, John Agapiou, Adrià Puigdomènech Badia, Karl Moritz Hermann, Yori Zwols, Georg Ostrovski, Adam Cain, Helen King, Christopher Summerfield, Phil Blunsom, Koray Kavukcuoglu, Demis Hassabis
Artificial neural networks are remarkably adept at sensory processing, sequence learning and reinforcement learning, but are limited in their ability to represent variables and data structures and to store data over long timescales, owing to the lack of an external memory. Here we introduce a machine learning model called a differentiable neural computer (DNC), which consists of a neural network that can read from and write to an external memory matrix, analogous to the random-access memory in a conventional computer...
October 12, 2016: Nature
Alexandra Pontefract, Gordon R Osinski, Charles S Cockell, Gordon Southam, Phil J A McCausland, Joseph Umoh, David W Holdsworth
Impact-generated lithologies have recently been identified as viable and important microbial habitats, especially within cold and arid regions such as the polar deserts on Earth. These unique habitats provide protection from environmental stressors, such as freeze-thaw events, desiccation, and UV radiation, and act to trap aerially deposited detritus within the fissures and pore spaces, providing necessary nutrients for endoliths. This study provides the first culture-independent analysis of the microbial community structure within impact-generated lithologies in a Mars analog environment, involving the analysis of 44,534 16S rRNA sequences from an assemblage of 21 rock samples that comprises three shock metamorphism categories...
October 2016: Astrobiology
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