keyword
MENU ▼
Read by QxMD icon Read
search

Phil

keyword
https://www.readbyqxmd.com/read/29349780/protective-effect-of-bled-exposed-conditioned-media-on-cell-injury
#1
Phil-Sun Oh, Eun-Mi Kim, Minjoo Kim, In Sun Kim, Yeon-Hee Han, SeokTae Lim, Myung-Hee Sohn, Myoung-Hwan Ko, Hwan-Jeong Jeong
Previous studies have reported that 450 nm blue light emitting diode (BLED) induces apoptosis through a mitochondria-mediated pathway in cancer cells and reduces the early stage tumor growth. The present study was performed to determine the effects of BLED-irradiated cell metabolites on cell injury. Our results showed that conditioned medium (CM) from cells irradiated with low-dose BLED (LCM) inhibited apoptosis and increased cell survival. Cell protection-related proteins were identified in cell metabolites of CM and LCM using 2-DE and MALDI-TOF analysis...
January 19, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29343796/integrated-climate-chemical-indicators-of-diffuse-pollution-from-land-to-water
#2
Per-Erik Mellander, Phil Jordan, Marianne Bechmann, Ophélie Fovet, Mairead M Shore, Noeleen T McDonald, Chantal Gascuel-Odoux
Management of agricultural diffuse pollution to water remains a challenge and is influenced by the complex interactions of rainfall-runoff pathways, soil and nutrient management, agricultural landscape heterogeneity and biogeochemical cycling in receiving water bodies. Amplified cycles of weather can also influence nutrient loss to water although they are less considered in policy reviews. Here, we present the development of climate-chemical indicators of diffuse pollution in highly monitored catchments in Western Europe...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337840/targeted-temperature-management-at-33%C3%A2-c-or-36%C3%A2-c-produces-equivalent-neuroprotective-effects-in-the-middle-cerebral-artery-occlusion-rat-model-of-ischemic-stroke
#3
Jung Ho Lee, Jisoo Lim, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim, Je Sung You
Targeted temperature management (TTM, 32°C to 36°C) is one of the most successful achievements in modern resuscitation medicine. It has become standard treatment for survivors of sudden cardiac arrest to minimize secondary brain damage. TTM at 36°C is just as effective as TTM at 33°C and is actually preferred because it reduces adverse TTM-associated effects. TTM also likely has direct neuroprotective effects in ischemic brains in danger of stroke. It remains unclear, however, whether higher temperature TTM is equally effective in protecting the brain from the effects of stroke...
January 15, 2018: Shock
https://www.readbyqxmd.com/read/29334828/an-unusual-combination-of-double-inlet-left-ventricle-with-discordant-ventriculoarterial-connections-and-bilateral-arterial-ducts
#4
Safak Alpat, Adrian Crucean, Tarak Desai, Simon McGuirk, Robert H Anderson, Phil Botha, David Barron
The presence of bilaterally persistent arterial ducts is an uncommon abnormality. Here, we describe the anatomy and successful management of an unusual patient with bilateral ducts in the setting of double inlet left ventricle, discordant ventriculoarterial connections, aortic atresia, and a severely hypoplastic and serpentine aortic arch.
January 1, 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29331987/what-to-look-for-in-winter-a-memoir-in-blindness
#5
Phil E M Smith
No abstract text is available yet for this article.
January 13, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29331888/a-longitudinal-analysis-of-ido-and-pdl1-expression-during-immune-or-targeted-therapy-in-advanced-melanoma
#6
Lukas Krähenbühl, Simone M Goldinger, Joanna Mangana, Katrin Kerl, Ines Chevolet, Liève Brochez, Christine Horak, Mitch Levesque, Reinhard Dummer, Phil F Cheng
A deepened understanding of the cellular and molecular processes in the tumor microenvironment is necessary for the development of precision immunotherapy (IT). We simultaneously investigated CD3, PDL1, and IDO by immunohistochemistry in paired biopsies from various organs of 43 metastatic melanoma patients treated with IT and targeted therapy (TT). Intraindividual biopsies taken after a period of weeks to months demonstrate discordant results in 30% of the cases. Overlap of IDO and PDL1 increased after therapy...
January 11, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29331658/sulforaphene-enhances-the-efficacy-of-photodynamic-therapy-in-anaplastic-thyroid-cancer-through-ras-raf-mek-erk-pathway-suppression
#7
Saswata Chatterjee, Yunhee Rhee, Phil-Sang Chung, Rui-Feng Ge, Jin-Chul Ahn
Sulforaphene (SFE), a natural isothiocyanate from cruciferous vegetables has shown a potential anticancer effect against cervical and lung cancer. Palliative treatments like photodynamic therapy (PDT) are being implemented for a long time however, the results are still not promising in case of aggressive cancers like anaplastic thyroid cancer. The objective of this work is to establish an alternative method with the combination of photofrin-PDT and sulforaphene, a natural isothiocyanate from cruciferous vegetables, against human anaplastic thyroid cancer to enhance the efficacy of PDT...
December 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29330260/race-and-socioeconomic-status-independently-affect-risk-of-major-amputation-in-peripheral-artery-disease
#8
Shipra Arya, Zachary Binney, Anjali Khakharia, Luke P Brewster, Phil Goodney, Rachel Patzer, Jason Hockenberry, Peter W F Wilson
BACKGROUND: Black race has been shown to be a risk factor for amputation in peripheral artery disease (PAD); however, race has been argued to be a marker for socioeconomic status (SES) rather than true disparity. The aim of this study is to study the impact of race and SES on amputation risk in PAD patients. METHODS AND RESULTS: Patients with incident PAD in the national Veterans Affairs Corporate Data Warehouse were identified from 2003 to 2014 (N=155 647). The exposures were race and SES (measured by median income in residential ZIP codes)...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29323437/parenteral-nutrition-safety-the-story-continues
#9
REVIEW
Phil Ayers, Joseph Boullata, Gordon Sacks
Parenteral nutrition (PN) is an important therapeutic modality used for a variety of indications in adults, children, and infants. PN is a complex, high-alert medication that requires appropriate education and ongoing competency assessment to ensure a safe process. PN is not recognized by many organizations as a medication, which leads to underreporting of errors. This article will provide important insight and recommendations to promote a safe PN process.
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29316343/circulating-monocyte-chemoattractant-protein-1-mcp-1-is-associated-with-cachexia-in-treatment-na%C3%A3-ve-pancreatic-cancer-patients
#10
Erin E Talbert, Heather L Lewis, Matthew R Farren, Mitchell L Ramsey, Jeffery M Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M Pawlik, Teresa A Zimmers, Gregory B Lesinski, Phil A Hart, Mary E Dillhoff, Carl R Schmidt, Denis C Guttridge
BACKGROUND: Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced disease and thus may be associated with disease progression rather than directly with the cachexia syndrome. Thus, we sought to assess potential biomarkers of cancer-induced cachexia in patients with earlier stages of disease...
January 7, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29316279/bowel-health-in-chronic-kidney-disease-patient-perceptions-differ-from-clinical-definitions
#11
Claire Trimingham, Stephen McDonald, Kathryn Dansie, Shilpa Jesudason, Randall Faull, Phil Clayton, Grace Liew, Richard Le Leu, Anthony Meade
BACKGROUND: The bowel health of those with chronic kidney disease (CKD) can be affected by medications, fluid/dietary allowances, reduced activity and pre-existing medical conditions. Patient perceptions of their bowel health can differ from those of health care professionals and the burden of gastrointestinal symptoms could be inaccurately reported. METHODS: Adults with CKD, including those undergoing haemodialysis, peritoneal dialysis and kidney transplant from four South Australian hospitals enrolled in the study...
January 8, 2018: Journal of Renal Care
https://www.readbyqxmd.com/read/29309260/recommended-metric-for-tracking-visibility-progress-in-the-regional-haze-rule
#12
Brett Gantt, Melinda Beaver, Brian Timin, Phil Lorang
For many Class I areas (national parks and wilderness areas with special air quality protections) in the western U.S., wildfire smoke and dust events can have a large impact on visibility. Currently, the Environmental Protection Agency's (EPA) 1999 Regional Haze Rule uses the 20% haziest days to track visibility changes over time even if they are dominated by smoke or dust. Visibility on the 20% haziest days has remained constant or degraded over the last 16 years at some Class I areas despite widespread emission reductions from anthropogenic sources...
January 8, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29308828/propofol-for-the-promotion-of-sleep-in-adults-in-the-intensive-care-unit
#13
REVIEW
Sharon R Lewis, Oliver J Schofield-Robinson, Phil Alderson, Andrew F Smith
BACKGROUND: People in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep deprivation affects physical and psychological health, and people perceive the quality of their sleep to be poor whilst in the ICU. Propofol is an anaesthetic agent which can be used in the ICU to maintain patient sedation and some studies suggest it may be a suitable agent to replicate normal sleep...
January 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29306683/allergists-opinions-on-anaphylaxis-and%C3%A2-epinephrine-administration-a-case-based-survey
#14
Jay A Lieberman, Phil Lieberman, Julie Wang
No abstract text is available yet for this article.
January 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29304806/enhancing-the-defensibility-of-examiners-marks-in-high-stake-osces
#15
Boaz Shulruf, Arvin Damodaran, Phil Jones, Sean Kennedy, George Mangos, Anthony J O'Sullivan, Joel Rhee, Silas Taylor, Gary Velan, Peter Harris
BACKGROUND: Most assessments in health professions education consist of knowledge-based examinations as well as practical and clinical examinations. Among the most challenging aspects of clinical assessments is decision making related to borderline grades assigned by examiners. Borderline grades are commonly used by examiners when they do not have sufficient information to make clear pass/fail decisions. The interpretation of these borderline grades is rarely discussed in the literature...
January 6, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29302701/structure-and-function-of-the-nppa-nppb-cluster-locus-during-heart-development-and-disease
#16
REVIEW
Joyce Man, Phil Barnett, Vincent M Christoffels
Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex and is not well understood...
January 4, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29299754/survey-on-using-ethical-principles-in-environmental-field-research-with-place-based-communities
#17
Dianne Quigley, Alana Levine, David A Sonnenfeld, Phil Brown, Qing Tian, Xiaofan Wei
Researchers of the Northeast Ethics Education Partnership (NEEP) at Brown University sought to improve an understanding of the ethical challenges of field researchers with place-based communities in environmental studies/sciences and environmental health by disseminating a questionnaire which requested information about their ethical approaches to these researched communities. NEEP faculty sought to gain actual field guidance to improve research ethics and cultural competence training for graduate students and faculty in environmental sciences/studies...
January 3, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29298482/wolff-cope-approach-to-the-ab-ring-of-the-sesterterpenoid-variecolin
#18
Michael R Krout, Christopher Edwin Henry, Thomas Jensen, Kun-Liang Phil Wu, Scott C Virgil, Brian M Stoltz
A stereoselective synthesis of the AB ring of the complex sesterterpenoid variecolin is presented. Our strategy features the development of a tandem Wolff/Cope rearrangement of α-diazo cyclobutyl ketones for the construction of fused, eight-membered carbocycles. Preliminary studies revealed a facile Wolff rearrangement but a difficult vinyl ketene cyclobutane Cope rearrangement. We have leveraged an efficient microwave-promoted tandem rearrangement to prepare the desired functionalized cyclooctadienones that we envision as potential key intermediates in the convergent synthesis of variecolin...
January 4, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29296668/chemical-proteomics-identifies-slc25a20-as-a-functional-target-of-the-ingenol-class-of-actinic-keratosis-drugs
#19
Christopher G Parker, Christian A Kuttruff, Andrea Galmozzi, Lars Jørgensen, Chien-Hung Yeh, Daniel J Hermanson, Yujia Wang, Marta Artola, Steven J McKerrall, Christopher M Josyln, Bjarne Nørremark, Georg Dünstl, Jakob Felding, Enrique Saez, Phil S Baran, Benjamin F Cravatt
The diterpenoid ester ingenol mebutate (IngMeb) is the active ingredient in the topical drug Picato, a first-in-class treatment for the precancerous skin condition actinic keratosis. IngMeb is proposed to exert its therapeutic effects through a dual mode of action involving (i) induction of cell death that is associated with mitochondrial dysfunction followed by (ii) stimulation of a local inflammatory response, at least partially driven by protein kinase C (PKC) activation. Although this therapeutic model has been well characterized, the complete set of molecular targets responsible for mediating IngMeb activity remains ill-defined...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29288389/principles-and-methods-of-in-silico-prioritization-of-non-coding-regulatory-variants
#20
REVIEW
Phil H Lee, Christian Lee, Xihao Li, Brian Wee, Tushar Dwivedi, Mark Daly
Over a decade of genome-wide association, studies have made great strides toward the detection of genes and genetic mechanisms underlying complex traits. However, the majority of associated loci reside in non-coding regions that are functionally uncharacterized in general. Now, the availability of large-scale tissue and cell type-specific transcriptome and epigenome data enables us to elucidate how non-coding genetic variants can affect gene expressions and are associated with phenotypic changes. Here, we provide an overview of this emerging field in human genomics, summarizing available data resources and state-of-the-art analytic methods to facilitate in-silico prioritization of non-coding regulatory mutations...
December 29, 2017: Human Genetics
keyword
keyword
4051
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"