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https://www.readbyqxmd.com/read/28340232/a-proposed-set-of-metrics-to-reduce-patient-safety-risk-from-within-the-anatomic-pathology-laboratory
#1
Peter Banks, Richard Brown, Alex Laslowski, Yvonne Daniels, Phil Branton, John Carpenter, Richard Zarbo, Ramses Forsyth, Yan-Hui Liu, Shane Kohl, Joachim Diebold, Shinobu Masuda, Tim Plummer, Eslie Dennis
Background: Anatomic pathology laboratory workflow consists of 3 major specimen handling processes. Among the workflow are preanalytic, analytic, and postanalytic phases that contain multistep subprocesses with great impact on patient care. A worldwide representation of experts came together to create a system of metrics, as a basis for laboratories worldwide, to help them evaluate and improve specimen handling to reduce patient safety risk. Method: Members of the Initiative for Anatomic Pathology Laboratory Patient Safety (IAPLPS) pooled their extensive expertise to generate a list of metrics highlighting processes with high and low risk for adverse patient outcomes...
March 18, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28326777/peptide-macrocyclization-inspired-by-non-ribosomal-imine-natural-products
#2
Lara R Malins, Justine Nicole deGruyter, Kevin J Robbins, Paul M Scola, Martin Eastgate, M Reza Ghadiri, Phil S Baran
A thermodynamic approach to peptide macrocyclization inspired by the cyclization of non-ribosomal peptide aldehydes is presented. The method provides access to structurally diverse macrocycles by exploiting the reactivity of transient macrocyclic peptide imines toward inter- and intramolecular nucleophiles. Reactions are performed in aqueous media, in the absence of side-chain protecting groups, and are tolerant of all proteinogenic functional groups. Macrocyclic products bearing non-native and rigidifying structural motifs, isotopic labels, and a variety of bioorthogonal handles are prepared, along with analogues of four distinct natural products...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28325012/eeg-patterns-of-subacute-stroke-patients-performing-motor-tasks-correlate-with-motor-functional-outcome-preliminary-results
#3
Wanjoo Park, Yun-Hee Kim, Sung-Phil Kim, Laehyun Kim
If an early predictor of motor functional outcome after stroke were available, stroke patients would receive more appropriate treatments for motor recovery. We performed a correlation analysis of the electroencephalography (EEG) signal patterns of nine subacute stroke patients (recorded 22.9 ± 7.1 days after onset) and their motor recovery rates (measured 100.2 ± 8.9 days after onset). The beta band spectral power in the bilateral motor cortex after physical upper limb movement correlated significantly with the motor recovery rates [Fugl-Meyer assessment (FMA) scores; Pearson's linear correlation, p <; 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323792/the-effect-of-intermittent-vest-cooling-on-thermoregulation-and-cardiovascular-strain-in-baseball-catchers
#4
Stacy Bishop, David J Szymanski, Greg A Ryan, Robert L Herron, Phil A Bishop
Baseball catchers are exposed to multiple physiological challenges while playing outside during the spring and summer months, many of which deal with recovery and thermoregulation. The purpose of this study was to investigate the effect of intermittent cooling on core temperature, cardiovascular strain, exertion, and recovery during a simulated catching performance in the heat. Six trained college-aged baseball catchers performed in a controlled, hot (35 °C) and humid (25% relative humidity) environment in a counter-balanced, cross-over design...
March 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28322900/structural-variations-of-the-prostatic-urethra-within-the-prostate-predict-the-severities-of-obstructive-symptoms-a-prospective-multicenter-observational-study
#5
Young Hwii Ko, Tae-Hwan Kim, Phil Hyun Song, Byung Hoon Kim, Bum Soo Kim, Ki Ho Kim, Jaeho Cho
OBJECTIVE: To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract symptom (LUTS). MATERIALS AND METHODS: After standardizing measurements, seven ultrasonography determined variables, that is, prostate volume, transitional zone volume, transitional zone to total volume ratio, presence of intraprostatic protrusion, prostatic urethral angle, prostatic urethral length (PUL), and PUL-to-volume ratio (rPUL), were obtained prospectively in 293 men that had not taken LUTS medication during the 3 months prior to initial visits...
March 17, 2017: Urology
https://www.readbyqxmd.com/read/28321632/metastatic-melanoma-moves-on-translational-science-in-the-era-of-personalized-medicine
#6
Mitchell P Levesque, Phil F Cheng, Marieke I G Raaijmakers, Annalisa Saltari, Reinhard Dummer
Progress in understanding and treating metastatic melanoma is the result of decades of basic and translational research as well as the development of better in vitro tools for modeling the disease. Here, we review the latest therapeutic options for metastatic melanoma and the known genetic and non-genetic mechanisms of resistance to these therapies, as well as the in vitro toolbox that has provided the greatest insights into melanoma progression. These include next-generation sequencing technologies and more complex 2D and 3D cell culture models to functionally test the data generated by genomics approaches...
March 20, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28321323/total-kidney-volume-as-a-biomarker-of-disease-progression-in-autosomal-dominant-polycystic-kidney-disease
#7
REVIEW
Navdeep Tangri, Ingrid Hougen, Ahsan Alam, Ronald Perrone, Phil McFarlane, York Pei
PURPOSE OF REVIEW: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by the formation of kidney cysts and kidney enlargement, which progresses to kidney failure by the fifth to seventh decade of life in a majority of patients. Disease progression is evaluated primarily through serum creatinine and estimated glomerular filtration rate (eGFR) measurements; however, it is known that serum creatinine and eGFR values typically do not change until the fourth or fifth decade of life...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28320868/trends-in-medical-and-nonmedical-use-of-prescription-opioids-among-us-adolescents-1976-2015
#8
Sean Esteban McCabe, Brady T West, Phil Veliz, Vita V McCabe, Sarah A Stoddard, Carol J Boyd
OBJECTIVES: Most US studies of national trends in medical and nonmedical use of prescription opioids have focused on adults. Given the limited understanding in these trends among adolescents, we examine national trends in the medical and nonmedical use of prescription opioids among high school seniors between 1976 and 2015. METHODS: The data used for the study come from the Monitoring the Future study of adolescents. Forty cohorts of nationally representative samples of high school seniors (modal age 18) were used to examine self-reported medical and nonmedical use of prescription opioids...
March 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/28320482/pressure-relieving-support-surfaces-a-randomised-evaluation-2-pressure-2-photographic-validation-sub-study-study-protocol-for-a-randomised-controlled-trial
#9
Elizabeth McGinnis, Sarah Brown, Howard Collier, Phil Faulks, Rachael Gilberts, Clare Greenwood, Valerie Henderson, Delia Muir, Andrea Nelson, Jane Nixon, Isabelle Smith, Nikki Stubbs, Kay Walker, Lyn Wilson, Susanne Coleman
BACKGROUND: PRESSURE 2 is a randomised evaluation of the clinical and cost effectiveness of two types of pressure relieving mattress for the prevention of pressure ulcers. The primary endpoint is the time to development of a Category ≥2 pressure ulcer. The current 'gold standard' for the identification of a Category ≥2 pressure ulcer is expert clinical assessment. Due to the appearance of the bed, it is not possible to achieve blinding of the endpoint. This therefore poses a risk to the internal validity of the study...
March 20, 2017: Trials
https://www.readbyqxmd.com/read/28318807/microrna-302d-targets-irf9-to-regulate-the-ifn-induced-gene-expression-in-sle
#10
Siobhán Smith, Thilini Fernando, Pei Wen Wu, Jane Seo, Joan Ní Gabhann, Olga Piskareva, Eoghan McCarthy, Donough Howard, Paul O'Connell, Richard Conway, Phil Gallagher, Eamonn Molloy, Raymond L Stallings, Grainne Kearns, Lindsy Forbess, Mariko Ishimori, Swamy Venuturupalli, Daniel Wallace, Michael Weisman, Caroline A Jefferies
Systemic lupus erythematosus (SLE) is a complex disease targeting multiple organs as a result of overactivation of the type I interferon (IFN) system, a feature currently being targeted by multiple biologic therapies against IFN-α. We have identified an estrogen-regulated microRNA, miR-302d, whose expression is decreased in SLE patient monocytes and identify its target as interferon regulatory factor (IRF)-9, a critical component of the transcriptional complex that regulates expression of interferon-stimulated genes (ISGs)...
March 17, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28318082/histopathological-tumour-viability-after-neoadjuvant-chemotherapy-influences-survival-in-resected-pancreatic-cancer-analysis-of-early-outcome-data
#11
Phil Townend, Phil R de Reuver, Terence C Chua, Anubhav Mittal, Stephen J Clark, Nick Pavlakis, Anthony J Gill, Jaswinder S Samra
BACKGROUND: Neoadjuvant therapy is increasingly recognized as an effective strategy prior to pancreatoduodenectomy. We investigate the role of neoadjuvant chemotherapy (NAC) followed by surgery and the predictive role of viable residual tumour cells histopathologically on outcomes. METHODS: The study population comprised of 195 consecutive patients with pancreatic adenocarcinoma who were treated with either NAC or a surgery-first (SF) strategy. Histopathological viable tumour cells were examined in the NAC patients and clinicopathological factors were correlated with overall survival...
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28316963/the-results-of-proximal-femoral-nail-for-intertrochanteric-fracture-in-hemodialysis-patient
#12
Kyung Sub Song, Sang Phil Yoon, Su Keon Lee, Seung Hwan Lee, Bong Seok Yang, Byeong Mun Park, Ick Hwan Yang, Beom Seok Lee, Ji Ung Yeom
PURPOSE: Hip fractures in hemodialysis patients are accompanied by high rates of complications and morbidities. Previous studies have mainly reported on nonunion and avascular necrosis of femoral neck fractures in this patient group. In this study the complication and clinical results of hemodialysis patients with intertrochanteric fractures treated with proximal femoral intramedullary nailing have been investigated through comparison with patients with normal kidney function. MATERIALS AND METHODS: Forty-seven patients were included; the hemodialysis group (n=17) and the control group with normal kidney function (n=30)...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28315840/highlights-from-this-issue
#13
Phil E M Smith, Geraint N Fuller
No abstract text is available yet for this article.
April 2017: Practical Neurology
https://www.readbyqxmd.com/read/28315036/diagnosing-chronic-pancreatitis
#14
REVIEW
Ahmad Anaizi, Phil A Hart, Darwin L Conwell
Diagnosing CP can range from routine in those with severe disease and obvious calcifications on CT imaging to elusive in those patients with early changes in CP. The workup of suspected CP should follow a progressively noninvasive to more invasive STEP-wise approach in a patient with a suspicious clinical presentation and risk factors that raise their pretest probability of disease. After a thorough history and physical examination, basic laboratories should be obtained such as lipase, amylase, metabolic panel, and indirect PFTs (fecal elastase-1, serum trypsin)...
March 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28304238/remote-motor-system-metabolic-profile-and-surgery-outcome-in-cervical-spondylotic-myelopathy
#15
Sorin C Craciunas, Mircea R Gorgan, Bogdan Ianosi, Phil Lee, Joseph Burris, Carmen M Cirstea
OBJECTIVE In patients with cervical spondylotic myelopathy (CSM), the motor system may undergo progressive functional/structural changes rostral to the lesion, and these changes may be associated with clinical disability. The extent to which these changes have a prognostic value in the clinical recovery after surgical treatment is not yet known. In this study, magnetic resonance spectroscopy (MRS) was used to test 2 primary hypotheses. 1) Based on evidence of corticospinal and spinocerebellar, rubro-, or reticulospinal tract degeneration/dysfunction during chronic spinal cord compression, the authors hypothesized that the metabolic profile of the primary motor cortices (M1s) and cerebellum, respectively, would be altered in patients with CSM, and these alterations would be associated with the extent of the neurological disabilities...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28302848/restacking-the-deck
#16
Phil Szuromi
No abstract text is available yet for this article.
March 17, 2017: Science
https://www.readbyqxmd.com/read/28302828/lifting-off-gold-films
#17
EDITORIAL
Phil Szuromi
No abstract text is available yet for this article.
March 17, 2017: Science
https://www.readbyqxmd.com/read/28301443/can-neck-strength-be-measured-using-a-single-maximal-contraction-in-a-simulated-contact-position
#18
Danielle M Salmon, Phil Handcock, S John Sullivan, Nancy J Rehrer, Brian Niven
Neck strengthening has been postulated to potentially reduce the incidence/severity of concussions and neck injuries in collision based sports. A quick and reliable method to assess neck strength would permit identification of those at risk and tracking of progress following injury. The purpose of this study was to determine if neck strength could be reliably assessed in a simulated contact posture using a single maximal contraction. During a single session 30 healthy male university students performed 3 maximal voluntary contractions of the neck musculature in each of the following directions: extension (Ext), flexion (Flx), left (LtFlx), and right lateral flexion (RtFlx)...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28301392/combined-electric-and-acoustic-stimulation-with-hearing-preservation-effect-of-cochlear-implant-low-frequency-cutoff-on-speech-understanding-and-perceived-listening-difficulty
#19
René H Gifford, Timothy J Davis, Linsey W Sunderhaus, Christine Menapace, Barbara Buck, Jillian Crosson, Lori O'Neill, Anne Beiter, Phil Segel
OBJECTIVE: The primary objective of this study was to assess the effect of electric and acoustic overlap for speech understanding in typical listening conditions using semidiffuse noise. DESIGN: This study used a within-subjects, repeated measures design including 11 experienced adult implant recipients (13 ears) with functional residual hearing in the implanted and nonimplanted ear. The aided acoustic bandwidth was fixed and the low-frequency cutoff for the cochlear implant (CI) was varied systematically...
March 15, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28298886/mapping-and-analysis-of-the-connectome-of-sympathetic-premotor-neurons-in-the-rostral-ventrolateral-medulla-of-the-rat-using-a-volumetric-brain-atlas
#20
Bowen Dempsey, Sheng Le, Anita Turner, Phil Bokiniec, Radhika Ramadas, Jan G Bjaalie, Clement Menuet, Rachael Neve, Andrew M Allen, Ann K Goodchild, Simon McMullan
Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) play a critical role in the generation of vasomotor sympathetic tone and are thought to receive convergent input from neurons at every level of the neuraxis; the factors that determine their ongoing activity remain unresolved. In this study we use a genetically restricted viral tracing strategy to definitively map their spatially diffuse connectome. We infected bulbospinal RVLM neurons with a recombinant rabies variant that drives reporter expression in monosynaptically connected input neurons and mapped their distribution using an MRI-based volumetric atlas and a novel image alignment and visualization tool that efficiently translates the positions of neurons captured in conventional photomicrographs to Cartesian coordinates...
2017: Frontiers in Neural Circuits
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