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https://www.readbyqxmd.com/read/28086934/electroacupuncture-plus-moxibustion-therapy-for-patients-with-major-depressive-disorder-study-protocol-for-a-randomized-controlled-trial
#1
Mikyung Kim, Eun-Ji Choi, Sung-Phil Kim, Jung-Eun Kim, Hyo-Ju Park, Ae-Ran Kim, Bok-Nam Seo, O-Jin Kwon, Jung Hyo Cho, Sun-Yong Chung, Joo-Hee Kim
BACKGROUND: Major depressive disorder (MDD) is one of the most prevalent mental health disorders and has a significant societal economic burden. Antidepressants and cognitive behavioral therapy are two primary interventions for the standardized treatment of MDD. However, their weaknesses, such as a low response rate, a high risk of adverse events from medication, and the high cost of cognitive behavioral therapy, have resulted in a need for complementary and alternative medicine (CAM)...
January 13, 2017: Trials
https://www.readbyqxmd.com/read/28081218/adiponectin-signaling-regulates-lipid-production-in-human-sebocytes
#2
Yu Ra Jung, Jin-Hyup Lee, Kyung-Cheol Sohn, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Seung-Phil Hong, Seong-Jun Seo, Seong-Jin Kim, Myung Im
Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that human sebaceous glands in vivo and sebocytes in vitro express adiponectin receptor and that adiponectin increased cell proliferation...
2017: PloS One
https://www.readbyqxmd.com/read/28081116/the-sharing-experimental-animal-resources-coordinating-holdings-search-framework-encouraging-reduction-replacement-and-refinement-in-animal-research
#3
Bethny Morrissey, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones, Ingunn Holen, Valerie Speirs
While significant medical breakthroughs have been achieved through using animal models, our experience shows that often there is surplus material remaining that is frequently never revisited but could be put to good use by other scientists. Recognising that most scientists are willing to share this material on a collaborative basis, it makes economic, ethical, and academic sense to explore the option to utilise this precious resource before generating new/additional animal models and associated samples. To bring together those requiring animal tissue and those holding this type of archival material, we have devised a framework called Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) with the aim of making remaining material derived from animal studies in biomedical research more visible and accessible to the scientific community...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28079199/structural-influence-of-proteins-upon-adsorption-to-mos2-nanomaterials-comparison-of-mos2-force-field-parameters
#4
Zonglin Gu, Phil De Luna, Zaixing Yang, Ruhong Zhou
Molybdenum disulfide (MoS2) has recently emerged as a promising nanomaterial in a wide range of applications due to its unique and impressive properties. For example, MoS2 has gained attention in the biomedical field because of its ability to act as an antibacterial and anticancer agent. However, the potential influence of this exciting nanomaterial on biomolecules is yet to be extensively studied. Molecular dynamics (MD) simulations are invaluable tools in the examination of protein interactions with nanomaterials such as MoS2...
January 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28075594/high-curvature-nanostructuring-enhances-probe-display-for-biomolecular-detection
#5
Phil De Luna, Sahar Mahshid, Jagotamoy Das, Binquan Luan, Edward H Sargent, Shana O Kelley, Ruhong Zhou
High-curvature electrodes facilitate rapid and sensitive detection of a broad class of molecular analytes. These sensors have reached detection limits not attained using bulk macroscale materials. It has been proposed that immobilized DNA probes are displayed at a high deflection angle on the sensor surface, allowing greater accessibility and more efficient hybridization. Here we report the first use of all-atom molecular dynamics simulations coupled with electrochemical experiments to explore the dynamics of ssDNA immobilized on high-curvature vs...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28075193/workshop-report-aerosol-delivery-to-spontaneously-breathing-tracheostomized-patients
#6
Ariel Berlinski, Arzu Ari, Phil Davies, Jim Fink, Carina Majaesic, Gregory Reychler, Taran Tatla, Israel Amirav
The number of pediatric and adult patients requiring tracheostomy has increased. Many of them require aerosol therapy as part of their treatment. Practitioners have little guidance on how to optimize drug delivery in this population. The following is a report of a workshop dedicated to review the current status of aerosol delivery to spontaneously breathing tracheostomized patients and to provide practice recommendations.
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28074654/rhodium-catalyzed-intramolecular-transannulation-reaction-of-alkynyl-thiadiazoles-enabled-5-n-fused-thiophenes
#7
Ji Eun Kim, Jinsub Lee, Hyunsik Yun, Yonghyeon Baek, Phil Ho Lee
A method for the synthesis of a wide range of fused thiophenes, including those fused with lactams, lactons, or cyclic ethers, was developed from a rhodium-catalyzed intramolecular transannulation reaction of alkynyl thiadiazoles. This transannulation reaction provides an efficient platform for the construction of a variety of 5,n-fused thiophenes from readily available starting materials together with the release of molecular nitrogen.
January 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28074482/remote-ischaemic-preconditioning-suppresses-endogenous-plasma-nitrite-during-ischaemia-reperfusion-a-randomised-controlled-crossover-pilot-study
#8
Ashok Nair, Sitara Khan, Sami Omar, Xiao-Qing Pei, Karen McNeill, Phil Chowienczyk, Andrew James Webb
AIM: To test the hypothesis that remote ischaemic preconditioning (RIPC) increases circulating endogenous local and systemic plasma [nitrite] during RIPC and ischaemia-reperfusion (IR) as a potential protective mechanism against ischaemia-reperfusion injury (IRI). METHODS: Six healthy male volunteers (mean age 29.5 ± 7.6 years) were randomised in a cross-over study to initially receive either RIPC (4 x 5 min cycles) to the left arm, or no RIPC (Control), both followed by an ischaemia-reperfusion (IR) sequence (20 min cuff inflation to 200 mmHg, 20 min reperfusion) to the right arm...
January 10, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28071095/cardiovascular-disease-and-laboratory-medicineby-crook-martin-chambers-john-and-chowienczyk-phil-london-acb-venture-publications-2015-99-pp-price-%C3%A2-25-isbn-978-0-902429-48-2
#9
https://www.readbyqxmd.com/read/28060834/estimating-the-cost-effectiveness-of-one-time-screening-and-treatment-for-hepatitis-c-in-korea
#10
Do Young Kim, Kwang-Hyub Han, Byungyool Jun, Tae Hyun Kim, Sohee Park, Thomas Ward, Samantha Webster, Phil McEwan
BACKGROUND AND AIMS: This study aims to investigate the cost-effectiveness of a one-time hepatitis C virus (HCV) screening and treatment program in South Korea where hepatitis B virus (HBV) prevails, in people aged 40-70, compared to current practice (no screening). METHODS: A published Markov model was used in conjunction with a screening and treatment decision tree to model patient cohorts, aged 40-49, 50-59 and 60-69 years, distributed across chronic hepatitis C (CHC) and compensated cirrhosis (CC) health states (82...
2017: PloS One
https://www.readbyqxmd.com/read/28053961/iron-supplementation-reverses-the-reduction-of-hydroxymethylcytosine-in-hepatic-dna-associated-with-chronic-alcohol-consumption-in-rats
#11
Stephanie A Tammen, Jung Eun Park, Phil Kyung Shin, Simonetta Friso, Jayong Chung, Sang-Woon Choi
BACKGROUND: Alcohol is known to affect two epigenetic phenomena, DNA methylation and DNA hydroxymethylation, and iron is a cofactor of ten-eleven translocation (TET) enzymes that catalyze the conversion from methylcytosine to hydroxymethylcytosine. In the present study we aimed to determine the effects of alcohol on DNA hydroxymethylation and further effects of iron on alcohol associated epigenetic changes. METHODS: Twenty-four male Sprague-Dawley rats were fed either Lieber-DeCarli alcohol diet (36% calories from ethanol) or Lieber-DeCarli control diet along with or without iron supplementation (0...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053612/ischemic-brain-injury-decreases-dynamin-like-protein-1-expression-in-a-middle-cerebral-artery-occlusion-animal-model-and-glutamate-exposed-ht22-cells
#12
Ah-Ram Jang, Phil-Ok Koh
Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expression in a focal cerebral ischemia animal model and glutamate-exposed hippocampal-derived cell line. Middle cerebral artery occlusion (MCAO) was surgically induced in adult male rats to induce focal cerebral ischemic injury. Brain tissues were collected 24 hours after the onset of MCAO. MCAO induces an increase in infarct volume and histopathological changes in the cerebral cortex...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28053521/association-between-adherence-to-medications-for-copd-and-medications-for-other-chronic-conditions-in-copd-patients
#13
Amol D Dhamane, Phil Schwab, Sari Hopson, Chad Moretz, Srinivas Annavarapu, Kate Burslem, Andrew Renda, Shuchita Kaila
BACKGROUND: Patients with COPD often have multiple comorbidities requiring use of multiple medications, and adherence rates for maintenance COPD (mCOPD) medications are already known to be suboptimal. Presence of comorbidities in COPD patients, and use of medications used to treat those comorbidities (non-COPD medications), may have an adverse impact on adherence to mCOPD medications. OBJECTIVE: The objective of the study was to evaluate the association between non-adherence to mCOPD medications and non-COPD medications in COPD patients...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28046047/expectation-or-sensorial-reality-an-empirical-investigation-of-the-biodynamic-calendar-for-wine-drinkers
#14
Wendy V Parr, Dominique Valentin, Phil Reedman, Claire Grose, James A Green
The study's aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors...
2017: PloS One
https://www.readbyqxmd.com/read/28042246/acute-pancreatitis-patient-registry-to-examine-novel-therapies-in-clinical-experience-apprentice-an-international-multicenter-consortium-for-the-study-of-acute-pancreatitis
#15
Georgios I Papachristou, Jorge D Machicado, Tyler Stevens, Mahesh Kumar Goenka, Miguel Ferreira, Silvia C Gutierrez, Vikesh K Singh, Ayesha Kamal, Jose A Gonzalez-Gonzalez, Mario Pelaez-Luna, Aiste Gulla, Narcis O Zarnescu, Konstantinos Triantafyllou, Sorin T Barbu, Jeffrey Easler, Carlos Ocampo, Gabriele Capurso, Livia Archibugi, Gregory A Cote, Louis Lambiase, Rakesh Kochhar, Tiffany Chua, Subhash Ch Tiwari, Haq Nawaz, Walter G Park, Enrique de-Madaria, Peter J Lee, Bechien U Wu, Phil J Greer, Mohannad Dugum, Efstratios Koutroumpakis, Venkata Akshintala, Amir Gougol
BACKGROUND: We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and to develop a platform for future randomized clinical trials. METHODS: The AP patient registry to examine novel therapies in clinical experience (APPRENTICE) was formed in July 2014. Detailed web-based questionnaires were then developed to prospectively capture information on demographics, etiology, pancreatitis history, comorbidities, risk factors, severity biomarkers, severity indices, health-care utilization, management strategies, and outcomes of AP patients...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28038978/management-of-organic-impurities-in-small-molecule-medicinal-products-deriving-safe-limits-for-use-in-early-development
#16
James Harvey, Andrew Fleetwood, Ron Ogilvie, Andrew Teasdale, Phil Wilcox, Steven Spanhaak
Management of organic non-mutagenic impurities (NMIs) in medicinal products is regulated by the ICH Q3A, B and C guidelines that are applicable at late stages of clinical development (Phase III onwards) and as a consequence there is no guidance for the assessment and control of NMIs in early clinical trials. An analysis of several key in vivo toxicology databases supports the ICH Q3A defined concept that a lifetime dose to 1 mg/day of a NMI would not represent a safety concern to patients. In conjunction with routine (Q)SAR approaches, this 1 mg/day value could be used as a universal qualification threshold for a NMI during any stage of clinical development...
December 27, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28038316/association-of-the-female-athlete-triad-risk-assessment-stratification-to-the-development-of-bone-stress-injuries-in-collegiate-athletes
#17
Adam S Tenforde, Jennifer L Carlson, Audrey Chang, Kristin L Sainani, Rebecca Shultz, Jae Hyung Kim, Phil Cutti, Neville H Golden, Michael Fredericson
BACKGROUND: The female athlete triad (referred to as the triad) contributes to adverse health outcomes, including bone stress injuries (BSIs), in female athletes. Guidelines were published in 2014 for clinical management of athletes affected by the triad. PURPOSE: This study aimed to (1) classify athletes from a collegiate population of 16 sports into low-, moderate-, and high-risk categories using the Female Athlete Triad Cumulative Risk Assessment score and (2) evaluate the predictive value of the risk categories for subsequent BSIs...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28026911/managing-glycaemia-in-older-people-with-type-2-diabetes-a-retrospective-primary-care-based-cohort-study-with-economic-assessment-of-patient-outcomes
#18
Jason Gordon, Phil McEwan, Marc Evans, Jorge Puelles, Alan Sinclair
AIMS: To describe the relative health and economic outcomes associated with different therapeutic approaches to managing older patients with type 2 diabetes failing metformin (M) monotherapy and escalated to second-line treatment. METHODS: The Clinical Practice Research Datalink (CPRD) database was used to inform a retrospective observational cohort study of patients with type 2 diabetes treated with M monotherapy requiring escalation (addition or switch) to a second-line oral regimen from 01-01-2008 to 31-12-2014...
December 27, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28026908/an-alternative-approach-to-modelling-hba1c-trajectories-in-patients-with-type-2-diabetes-mellitus
#19
Phil McEwan, Hayley Bennett, Lei Qin, Klas Bergenheim, Jason Gordon, Marc Evans
AIMS: Time-dependent HbA1c trajectories in health economic models of type 2 diabetes mellitus (T2DM) are typically informed by the UK Prospective Diabetes Study (UKPDS). However, this approach may not accurately predict HbA1c progression in patients who do not conform to the demographic profile of the original UKPDS cohort. This study aimed to develop an alternative mathematical model (MM) to simulate HbA1c progression in T2DM. MATERIALS AND METHODS: A systematic literature review identified studies, published from 2005 to 2015, that reported HbA1c in adult T2DM patients over a minimum duration of 18 months...
December 27, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28025509/a-high-throughput-rna-extraction-for-sprouted-single-seed-barley-hordeum-vulgare-l-rich-in-polysaccharides
#20
Abdur Rashid, Thomas Baldwin, Michael Gines, Phil Bregitzer, Kathy Esvelt Klos
Germinated seed from cereal crops including barley (Hordeum vulgare L.) is an important tissue to extract RNA and analyze expression levels of genes that control aspects of germination. These tissues are rich in polysaccharides and most methods for RNA extraction are not suitable to handle the excess polysaccharides. Here, we compare the current methods for RNA extraction applicable to germinated barley tissue. We found that although some of these standard methods produced high-quality RNA, the process of extraction was drastically slow, mostly because the frozen seed tissue powder from liquid N₂ grinding became recalcitrant to buffer mixing...
December 22, 2016: Plants (Basel, Switzerland)
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