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https://www.readbyqxmd.com/read/28632990/shortening-gametes-co-incubation-time-improves-live-birth-rate-for-couples-with-a-history-of-fragmented-embryos
#1
Anne Le Bras, Laetitia Hesters, Vanessa Gallot, Cathie Tallet, Gerard Tachdjian, Nelly Frydman
Short gamete co-incubation (SGCO) consists in decreasing the duration of contact between oocytes and sperm from the standard overnight insemination (SOI) toward 2 hours. However, the effectiveness of this technique to improve in vitro fertilization and embryo transfer (IVF-ET) outcomes remains controversial. Our study was designed to evaluate the efficiency of SGCO in a poor prognosis population with a history of fragmented embryos defined by the presence of at least 50% of the embryos with more than 25% of cytoplasmic fragments...
June 20, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28601410/total-number-of-oocytes-and-zygotes-are-predictive-of-live-birth-pregnancy-in-fresh-donor-oocyte-in%C3%A2-vitro-fertilization-cycles
#2
Eduardo Hariton, Keewan Kim, Sunni L Mumford, Marissa Palmor, Pietro Bortoletto, Eden R Cardozo, Anatte E Karmon, Mary E Sabatini, Aaron K Styer
OBJECTIVE: To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN: Retrospective cohort study. SETTING: Academic reproductive medicine practice. PATIENT(S): Two hundred thirty-seven consecutive fresh donor oocyte IVF-ET cycles from January 1, 2007 to December 31, 2013 at the Massachusetts General Hospital Fertility Center...
June 7, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28580513/cumulative-live-birth-and-surplus-embryo-incidence-after-frozen-thaw-cycles-in-pcos-how-many-oocytes-do-we-need
#3
Yuan-Hui Chen, Qian Wang, Ya-Nan Zhang, Xiao Han, Dong-Han Li, Cui-Lian Zhang
PURPOSE: This study aimed to evaluate the cumulative live birth rate (CLBR) and surplus embryo rate of polycystic ovarian syndrome (PCOS) patients during in vitro fertilization and embryo transfer (IVF-ET) treatment. METHODS: In this retrospective cohort study, we analyzed 1142 PCOS patients who underwent first IVF in our institution between January 2011 and December 2014. All patients were categorized into five groups according to the number of oocytes retrieved...
June 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28540311/impacts-of-anti-dsdna-antibody-on-in-vitro-fertilization-embryo-transfer-and-frozen-thawed-embryo-transfer
#4
Jiao Fan, Yiping Zhong, Cuina Chen
Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA- group), and 121 women with negative ANA and anti-dsDNA (ANA-/anti-dsDNA- group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28505290/supraphysiologic-estradiol-is-an-independent-predictor-of-low-birth-weight-in-full-term-singletons-born-after-fresh-embryo-transfer
#5
N Pereira, R T Elias, P J Christos, A C Petrini, K Hancock, J P Lekovich, Z Rosenwaks
STUDY QUESTION: Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? SUMMARY ANSWER: Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. WHAT IS KNOWN ALREADY: The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28466814/association-of-leukemia-inhibitory-factor-gene-polymorphism-and-in-vitro-fertilization-outcome-in-a-population-in-northern-iran
#6
M Alipour, F Mashayekhi, Z Salehi
Several studies have been demonstrated that endometrial leukemia inhibitory factor (LIF) is important in embryo implantation. LIF is a secreted glycoprotein with a variety of biological functions including stimulation of cell proliferation, differentiation and survival that are all essential for blastocyete development and implantation. The LIF receptor activates several signaling pathways in diverse cell types, including Jak/STAT, MAPK and PI3-kinase pathways in the endometrium of fertile woman. It has been suggested that the initial lower expression of LIF in proliferative phase may be one of the causes for multiple failure of implantation...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28466568/physiological-and-pathological-angiogenesis-in-endometrium-at-the-time-of-embryo-implantation
#7
Xiaoyan Chen, Gene Chi Wai Man, Yingyu Liu, Fangrong Wu, Jin Huang, Tin Chiu Li, Chi Chiu Wang
Embryo establishes contact with the endometrium during implantation. Proper endometrial vascular development and maintenance at the time of embryo implantation is crucial for successful pregnancy. Vascular development at the maternal-embryo interface can be regulated by various cell types, of which uterine natural killer (uNK) cells play an important role. Abnormal angiogenesis and uNK cell number/function may lead to reproductive failure, particularly in women with recurrent miscarriage (RM) and women with recurrent implantation failure (RIF) after IVF-ET treatment, which are the important clinical hurdles in reproductive medicine to overcome...
May 3, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28447502/the-effect-of-endometrial-injury-on-implantation-and-clinical-pregnancy-rates
#8
Dan Levin, Joseph Hasson, Aviad Cohen, Yuval Or, Baris Ata, Lilia Barzilay, Benny Almog
AIM: To assess the effect of endometrial scratching (ES) on in vitro fertilization-embryo transfer outcome (IVF-ET) Materials and methods: Retrospective matched case control study including all fresh IVF cycles performed between January 2006 and December 2012 at an academic IVF center. ES with an endometrial biopsy catheter was performed in the cycle preceding the index IVF cycle. Patients (n = 238) were pair matched with controls according to age, number of previous failed IVF cycles and number of embryos transferred...
April 27, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28422984/the-impact-of-atosiban-on-pregnancy-outcomes-in-women-undergoing-in-vitro-fertilization-embryo-transfer-a-meta-analysis
#9
Qian-Yi Huang, Min-Hua Rong, Ai-Hua Lan, Xiao-Miao Lin, Xing-Gu Lin, Rong-Quan He, Gang Chen, Mu-Jun Li
BACKGROUND: Atosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF). METHODS: Databases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF...
2017: PloS One
https://www.readbyqxmd.com/read/28388872/associations-of-combined-polymorphisms-of-the-platelet-membrane-glycoproteins-ia-and-iiia-and-the-platelet-endothelial-cell-adhesion-molecule-1-and-p-selectin-genes-with-ivf-implantation-failures
#10
Nikolaos Vlachadis, Vasileios Tsamadias, Nikolaos Vrachnis, Georgios Kaparos, Nikolaos Vitoratos, Evaggelia Kouskouni, Emmanuel Economou
The aim of the study was to investigate the combined impact of the genetic heterogeneity of the glycoproteins Ia (GpIa) and IIIa (GpIIIa) and the platelet-endothelial cell adhesion molecule-1 (PECAM-1) and P-Selectin genes on IVF embryo transfer implantation failures (IVF-ET failures). Sixty nulligravida women with previous IVF-ET failures and 60 fertile controls were genotyped for the GpIa-C807T, GpIIIa-PlA1/PA2, PECAM-1-C373G (Leu125Val) and P-Selectin-A37674C (Thr715Pro) polymorphisms by pyrosequencing. Compared with wild-type combined homozygotes, carriers of combinations of risk alleles in two gene loci were at significantly increased risk for IVF-ET failure, whereas carriers of the combination of GpIa-807T, GpIIIa-PlA2 and PECAM-1-373G alleles had OR = 52...
April 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28355686/-retrospective-analysis-of-outcomes-of-selectively-or-spontaneously-reduced-multiple-pregnancies-out-of-6-917-in-vitro-fertilization-embryo-transfer-pregnancy-cycles
#11
Q L Chen, H Ye, X Y Ding, X L Shen, G N Huang
Objective: To analyze the effects of fetal reduction in early pregnancy on obstetric and neonatal outcomes of spontaneously or selectively reduced multiple pregnancies produced by in vitro fertilization-embryo transfer (IVF-ET). Methods: Retrospective study of 6 917 clinical pregnancies from IVF-ET cycles, including 754 multiple pregnancies divided into two groups according to the remaining fetus number: reduced singleton group (n=599) and reduced twin group (n=155); and maternal and neonatal outcomes of two groups were compared to primary singleton group (n=3 589) and primary twin group (n=2 574)...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28328856/the-influence-of-different-growth-hormone-addition-protocols-to-poor-ovarian-responders-on-clinical-outcomes-in-controlled-ovary-stimulation-cycles-a-systematic-review-and-meta-analysis
#12
REVIEW
Xue-Li Li, Li Wang, Fang Lv, Xia-Man Huang, Li-Ping Wang, Yu Pan, Xiao-Mei Zhang
BACKGROUND: Growth hormone (GH) is used as an adjuvant therapy in in vitro fertilization and embryo transfer (IVF-ET) for poor ovarian responders, but findings for its effects on outcomes of IVF have been conflicting. The aim of the study was to compare IVF-ET outcomes among women with poor ovarian responders, and find which subgroup can benefit from the GH addition. METHODS: We searched the databases, using the terms "growth hormone," "GH," "IVF," "in vitro fertilization...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28288882/clinical-outcomes-of-patients-with-heterotopic-pregnancy-after-surgical-treatment
#13
Yiqi Guan, Caihong Ma
STUDY OBJECTIVE: This study aimed to review surgical management and clinical outcomes of patients with heterotopic pregnancy (HP) who underwent in vitro fertilization and embryo transfer (IVF-ET) and surgical treatment at the Assisted Reproductive Technology Center of Peking University Third Hospital from January 2010 to December 2015. DESIGN: We retrospectively analyzed 56 patients' general characteristics, diagnostic features, surgical management, and clinical outcomes according to medical records and follow-up telephone interviews...
March 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28242968/salpingoscopy-an-adjuvant-to-laparoscopy-in-evaluation-of-infertile-women
#14
Vineet V Mishra, Rajani Nawal, Rohina S Aggarwal, S Choudhary, Tanvir Singh, Urmila Sharma, Ritu Agarwal
OBJECTIVE: To evaluate salpingoscopic tubal mucosal grading and to find out correlation between laparoscopic external tubal appearance and salpingoscopic mucosal appearance. DESIGN: Prospective observational study. INTERVENTION: Salpingoscopy and laparoscopy. MATERIALS AND METHODS: Thirty-seven infertile women between 21 and 40 years of age group who attended infertility clinic at IKDRC, Ahmedabad, from May 2015 to August 2015, were enrolled in the study...
February 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28138191/intestinal-obstruction-due-to-congenital-malrotation-complicating-a-multiple-pregnancy-a-rare-case-report
#15
Yuzhu Yin, Chuo Li, Chengfang Xu, Lingling Wu, Ni Deng, Hongying Hou, Bin Wu
Intestinal obstruction due to congenital intestinal malrotation is usually diagnosed in neonates but may, in rare cases, occur during pregnancy. The absence of specific symptoms in combination with its low incidence makes timely detection of intestinal malrotation-related obstruction difficult in expectant mothers. We present a rare case of a 23-year-old woman with a twin pregnancy following in vitro fertilization-embryo transfer (IVF-ET) who presented with symptoms of intestinal obstruction at 22+4 weeks of gestation...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28130869/proteomic-analysis-of-human-follicular-fluid-in-poor-ovarian-responders-during-in-vitro-fertilization
#16
Jae Won Oh, Seul Ki Kim, Kyung-Cho Cho, Min-Sik Kim, Chang Suk Suh, Jung Ryeol Lee, Kwang Pyo Kim
Poor ovarian response (POR) observed in controlled ovarian stimulation (COS) is often observed during in vitro fertilization and embryo transfer (IVF-ET) cycles and is a major problem. A POR has been found to be related to several factors, including advanced age, high body mass index, and history of ovarian or pelvic surgery. However, it is difficult to predict POR, as there are no specific biomarkers known. In this study, we used quantitative proteomic analyses to investigate potential biomarkers that can predict poor response during IVF based on follicular fluid samples...
January 28, 2017: Proteomics
https://www.readbyqxmd.com/read/28099907/increased-incidence-of-ectopic-pregnancy-after-in-vitro-fertilization-in-women-with-decreased-ovarian-reserve
#17
Shengli Lin, Rui Yang, Hongbin Chi, Ying Lian, Jiejing Wang, Shuo Huang, Cuiling Lu, Ping Liu, Jie Qiao
The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5-5-fold compared with natural conceptions.Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L)...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28090462/pretreatment-of-normal-responders-in-fresh-in-vitro-fertilization-cycles-a-comparison-of-transdermal-estradiol-and-oral-contraceptive-pills
#18
Nigel Pereira, Allison C Petrini, Zhen N Zhou, Jovana P Lekovich, Isaac Kligman, Zev Rosenwaks
OBJECTIVE: The aim of this study was to investigate the impact of pretreatment with transdermal estradiol (E2) compared to oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh in vitro fertilization (IVF)-embryo transfer (ET) cycles. METHODS: A retrospective cohort study was performed of normal responders undergoing fresh IVF-ET cycles who received pretreatment with transdermal E2 versus OCPs prior to fresh IVF-ET...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28073982/urinary-triclosan-concentrations-and-early-outcomes-of-in-vitro-fertilization-embryo-transfer
#19
Rui Hua, Yao Zhou, Biao Wu, Zhongwei Huang, Yongtong Zhu, Yali Song, Yanhong Yu, Hong Li, Song Quan
Triclosan (TCS) exists ubiquitously in the environment. Several in vitro and in vivo studies have demonstrated that TCS exerts endocrine disruptive effects on reproduction, but data from human populations are limited and conflicting. The objective of our study was to investigate whether high urinary TCS concentration is adversely associated with early reproductive outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET). This prospective cohort study was conducted from September 2015 to June 2016, including 156 infertile women undergoing their first IVF-ET cycle...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28069482/ovarian-response-and-in%C3%A2-vitro-fertilization-outcomes-after-salpingectomy-does-salpingectomy-indication-matter
#20
Nigel Pereira, Katherine P Pryor, Anna Voskuilen-Gonzalez, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
STUDY OBJECTIVE: To investigate whether the ovarian response and pregnancy outcomes of patients undergoing in vitro fertilization (IVF) after salpingectomy are affected by the underlying indication for salpingectomy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-3). SETTING: University-affiliated fertility center. PATIENTS: All patients age <37 years undergoing IVF within 12 months of laparoscopic salpingectomy...
March 2017: Journal of Minimally Invasive Gynecology
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