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https://www.readbyqxmd.com/read/29677648/algal-growth-inhibition-test-results-of-425-organic-chemical-substances
#1
Kresten Ole Kusk, Anne Munch Christensen, Niels Nyholm
The toxicity towards the algal species Pseudokirchneriella subcapitata of 425 organic chemical substances was tested in a growth inhibition test. Precautions were taken to prevent loss of the compounds from the water phase and the test system (closed test system, low biomass, shorter test duration, silanized glass) and to keep pH constant by applying a higher alkalinity. Chemical phase distribution was modelled taking ionization, volatilisation, and adsorption to glass and biomass into consideration. If the modelled water concentration was below 90% of the nominal concentration the calculated EC values were corrected accordingly...
April 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29677528/low-arsenic-bioaccessibility-by-fixation-in-nanostructured-iron-hydr-oxides-quantitative-identification-of-as-bearing-phases
#2
Virginia S T Ciminelli, Daphne C Antônio, Claudia L Caldeira, Erico T F Freitas, Itamar Daniel Delbem, Marcus M Fernandes, Massimo Gasparon, Jack C Ng
A new analytical protocol was developed to provide quantitative, single-particle identification of arsenic in heterogeneous nanoscale mineral phases in soil samples, with a view to establishing its potential risk to human health. Microscopic techniques enabled quantitative, single-particle identification of As-bearing phases in twenty soil samples collected in a gold mining district with arsenic concentrations in range of 8 to 6354 mg kg-1 . Arsenic is primarily observed in association with iron (hydr) oxides in fine intergrowth with phyllosilicates...
March 29, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29677410/mapping-drug-overdose-demographic-and-socioeconomic-characteristics-in-the-community
#3
Brenda L Rooney, Mitchell T Voter, Christopher M Eberlein, Andrea J Schossow, Cathy L Fischer
INTRODUCTION: Drug use and drug overdose have increased at an alarming rate. OBJECTIVE: To identify demographic and neighborhood social and economic factors associated with higher risk of overdose. These findings can be used to inform development of community programs and appropriately devote resources to prevent and treat drug abuse. METHODS: The electronic health records of all patients seen in the emergency department or admitted to the hospital for a drug overdose in 2016 at Gundersen Health System in La Crosse, Wisconsin, were reviewed retrospectively...
March 2018: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#4
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29677074/frailty-inflammatory-markers-and-waitlist-mortality-among-patients-with-end-stage-renal-disease-in-a-prospective-cohort-study
#5
Mara A McAdams-DeMarco, Hao Ying, Alvin G Thomas, Fatima Warsame, Ashton A Shaffer, Christine E Haugen, Jacqueline M Garonzik-Wang, Niraj M Desai, Ravi Varadhan, Jeremy Walston, Silas P Norman, Dorry L Segev
BACKGROUND: Among community-dwelling older adults, frailty is associated with heightened markers of inflammation and subsequent mortality. Although frailty is common among ESRD patients, the role of frailty and markers of inflammation in this population remains unclear. We quantified these associations in patients on the kidney transplant (KT) waitlist and tested whether frailty and/or markers of inflammation improve waitlist mortality risk prediction. METHODS: We studied 1,975 ESRD patients on the KT waitlist (11/1/09-2/28/17) in a multi-center cohort study of frailty...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676693/intraoperative-evaluation-of-local-cerebral-hemodynamic-change-by-indocyanine-green-videoangiography-prediction-of-incidence-and-duration-of-postoperative-transient-neurological-events-in-patients-with-moyamoya-disease
#6
Kenji Uda, Yoshio Araki, Shinsuke Muraoka, Shinji Ota, Kentaro Wada, Kinya Yokoyama, Masahiro Nishihori, Takashi Izumi, Sho Okamoto, Toshihiko Wakabayashi
OBJECTIVE Transient neurological events (TNEs) occur frequently in the acute phase after direct bypass surgery for moyamoya disease (MMD), but there is currently no way to predict them. FlowInsight is a specialized software for analyzing indocyanine green (ICG) videoangiography taken with a surgical microscope. The purpose of this study was to investigate whether intraoperative evaluation of local hemodynamic changes around anastomotic sites using FlowInsight could predict the incidence and duration of TNEs...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676636/observed-home-dampness-and-mold-are-associated-with-sustained-spikes-in-personal-exposure-to-particulate-matter-less-than-10-%C3%AE-m-in-diameter-in-exacerbation-prone-children-with-asthma
#7
Cullen M Dutmer, Allison M Schiltz, Kristy L Freeman, Matthew J Christie, Juana A Cerna, Seung-Hyun Cho, Ryan T Chartier, Jonathan W Thornburg, Katharine L Hamlington, James L Crooks, Tasha E Fingerlin, David A Schwartz, Andrew H Liu
RATIONALE: Home dampness and mold are associated with asthma severity and exacerbations, but little is known about the nature of these exposures in at-risk children. OBJECTIVES: To test the hypothesis that observed dampness, water damage, and mold in the home are associated with higher exposure to particulate matter less than 10 μm in diameter in a cohort of at-risk children with asthma. METHODS: We performed a pilot study in 8- to 16-year-old children with exacerbation-prone asthma (n = 29; Denver Asthma Panel Study)...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#8
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29676517/impact-of-changes-in-inflammation-on-estimated-10-year-cardiovascular-risk-in-rheumatoid-arthritis
#9
Zhi Yu, Nicole Yang, Brendan M Everett, Michelle Frits, Christine Iannaccone, Jonathan Coblyn, Michael Weinblatt, Nancy Shadick, Daniel H Solomon, Katherine P Liao
BACKGROUND: Validated cardiovascular (CV) risk estimates were developed in populations with relatively stable inflammatory levels. In rheumatoid arthritis (RA), patients routinely experience significant changes in inflammation. We tested whether changes in inflammation impact estimated CV risk as measured using validated population-based risk calculators. METHODS: We studied participants in a prospective RA cohort. We included participants who experienced a decrease (CRP decrease group) or increase (CRP increase group) of ≥10mg/L in C-reactive protein (CRP) at 2 consecutive time points, 1 year apart...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29676337/familial-aggregation-of-mood-disorders-among-relatives-of-schizophrenia-probands-admitted-in-a-hospital-in-south-eastern-nigeria-a-family-comparative-study
#10
Justus Uchenna Onu, Jude Uzoma Ohaeri
Introduction: The debate on the current nosological status of schizophrenia and mood disorders as distinct entities is very active among scholars. There is a paucity of genetic epidemiological data to contribute an African perspective to this debate. Aim: This study aimed to assess the morbid risk of mood disorders in the relatives of schizophrenia probands, in comparison with the families of a sample of healthy controls. Subjects and Methods: This study elicited the information on the morbid risk of mood disorders among 5259 relatives of schizophrenia probands (n = 138) and 6734 relatives of healthy controls (n = 138) through direct interview of patients, available relatives of patients and the comparison group...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676281/risk-thresholds-for-alcohol-consumption-combined-analysis-of-individual-participant-data-for-599-912-current-drinkers-in-83-prospective-studies
#11
Angela M Wood, Stephen Kaptoge, Adam S Butterworth, Peter Willeit, Samantha Warnakula, Thomas Bolton, Ellie Paige, Dirk S Paul, Michael Sweeting, Stephen Burgess, Steven Bell, William Astle, David Stevens, Albert Koulman, Randi M Selmer, W M Monique Verschuren, Shinichi Sato, Inger Njølstad, Mark Woodward, Veikko Salomaa, Børge G Nordestgaard, Bu B Yeap, Astrid Fletcher, Olle Melander, Lewis H Kuller, Beverley Balkau, Michael Marmot, Wolfgang Koenig, Edoardo Casiglia, Cyrus Cooper, Volker Arndt, Oscar H Franco, Patrik Wennberg, John Gallacher, Agustín Gómez de la Cámara, Henry Völzke, Christina C Dahm, Caroline E Dale, Manuela M Bergmann, Carlos J Crespo, Yvonne T van der Schouw, Rudolf Kaaks, Leon A Simons, Pagona Lagiou, Josje D Schoufour, Jolanda M A Boer, Timothy J Key, Beatriz Rodriguez, Conchi Moreno-Iribas, Karina W Davidson, James O Taylor, Carlotta Sacerdote, Robert B Wallace, J Ramon Quiros, Rosario Tumino, Dan G Blazer, Allan Linneberg, Makoto Daimon, Salvatore Panico, Barbara Howard, Guri Skeie, Timo Strandberg, Elisabete Weiderpass, Paul J Nietert, Bruce M Psaty, Daan Kromhout, Elena Salamanca-Fernandez, Stefan Kiechl, Harlan M Krumholz, Sara Grioni, Domenico Palli, José M Huerta, Jackie Price, Johan Sundström, Larraitz Arriola, Hisatomi Arima, Ruth C Travis, Demosthenes B Panagiotakos, Anna Karakatsani, Antonia Trichopoulou, Tilman Kühn, Diederick E Grobbee, Elizabeth Barrett-Connor, Natasja van Schoor, Heiner Boeing, Kim Overvad, Jussi Kauhanen, Nick Wareham, Claudia Langenberg, Nita Forouhi, Maria Wennberg, Jean-Pierre Després, Mary Cushman, Jackie A Cooper, Carlos J Rodriguez, Masaru Sakurai, Jonathan E Shaw, Matthew Knuiman, Trudy Voortman, Christa Meisinger, Anne Tjønneland, Hermann Brenner, Luigi Palmieri, Jean Dallongeville, Eric J Brunner, Gerd Assmann, Maurizio Trevisan, Richard F Gillum, Ian Ford, Naveed Sattar, Mariana Lazo, Simon G Thompson, Pietro Ferrari, David A Leon, George Davey Smith, Richard Peto, Rod Jackson, Emily Banks, Emanuele Di Angelantonio, John Danesh
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank)...
April 14, 2018: Lancet
https://www.readbyqxmd.com/read/29675986/efficacy-and-safety-of-extracorporeal-shock-wave-therapy-for-acute-and-chronic-soft-tissue-wounds-a-systematic-review-and-meta-analysis
#12
Li Zhang, Xiao-Bing Fu, Shuo Chen, Zhan-Bo Zhao, Christoph Schmitz, Chang-Shui Weng
This study aimed to evaluate and compare the effects of extracorporeal shock wave therapy (ESWT) and conventional wound therapy (CWT) for acute and chronic soft tissue wounds. All English-language articles on ESWT for acute and chronic soft tissue wounds indexed in PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Library, Physiotherapy Evidence Database, and HealthSTAR published prior to June 2017 were included, as well as corresponding articles cited in reference lists of related review articles...
April 19, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29675890/the-prevalence-and-potential-determinants-of-dysmenorrhoea-and-other-pelvic-pain-in-women-a-prospective-study
#13
Antoinette Righarts, Lauren Osborne, Jennie Connor, Wayne Gillett
OBJECTIVE: To estimate the prevalence of pelvic pain, and model associations with potential demographic, obstetric, gynaecological, and psychosocial determinants. DESIGN, SETTING AND SAMPLE: A cohort study of women born between 1972-1973 in Dunedin, New Zealand, most recently assessed when aged 38 years (95% of survivors retained); 429 women were eligible for analysis. METHODS: Women self-completed reproductive health questionnaires at ages 21, 26, 32 and 38 years, with questions on dysmenorrhoea at ages 13 and 15, and on all pelvic pain at age 38...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29675817/combined-acute-ecotoxicity-of-malathion-and-deltamethrin-to-daphnia-magna-crustacea-cladocera-comparison-of-different-data-analysis-approaches
#14
Héla Toumi, Moncef Boumaiza, Maurice Millet, Claudemir Marcos Radetski, Baba Issa Camara, Vincent Felten, Jean-François Masfaraud, Jean-François Férard
We studied the combined acute effect (i.e., after 48 h) of deltamethrin (a pyrethroid insecticide) and malathion (an organophosphate insecticide) on Daphnia magna. Two approaches were used to examine the potential interaction effects of eight mixtures of deltamethrin and malathion: (i) calculation of mixture toxicity index (MTI) and safety factor index (SFI) and (ii) response surface methodology coupled with isobole-based statistical model (using generalized linear model). According to the calculation of MTI and SFI, one tested mixture was found additive while the two other tested mixtures were found no additive (MTI) or antagonistic (SFI), but these differences between index responses are only due to differences in terminology related to these two indexes...
April 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29675762/high-risk-stage-ii-colon-cancer-not-all-risks-are-created-equal
#15
Blake D Babcock, Mayada A Aljehani, Brice Jabo, Audrey H Choi, John W Morgan, Matthew J Selleck, Fabrizio Luca, Elizabeth Raskin, Mark E Reeves, Carlos A Garberoglio, Sharon S Lum, Maheswari Senthil
INTRODUCTION: Adjuvant chemotherapy is recommended in patients with stage II colon cancer with high-risk features (HRF). However, there is no quantification of the amount of risk conferred by each HRF or the overall survival (OS) benefit gained by chemotherapy based on the risk factor. OBJECTIVE: To assess survival benefits associated with adjuvant chemotherapy among stage II colon cancer patients having one or more HRF [T4 tumors, less than 12 lymph nodes examined (< 12LN), positive margins, high-grade tumor, perineural invasion (PNI), and lymphovascular invasion (LVI)]...
April 19, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#16
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29675634/investigation-of-circle-of-willis-variants-and-hemodynamic-parameters-in-twins-using-transcranial-color-coded-doppler-sonography
#17
Bianka Forgó, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Levente Littvay, Corrado Fagnani, Maria Antonietta Stazi, Giorgio Meneghetti, Emanuela Medda, Filippo Farina, Claudio Baracchini
Morphological and hemodynamic variations of the circle of Willis (CW) may have an important impact on cerebrovascular events. However, the environmental and genetic influence remains unclear. For this reason we studied the variations and hemodynamic parameters of the CW in twins using transcranial color-coded sonography (TCCS). Sixty-four twins, 19 monozygotic (MZ) and 13 dizygotic (DZ) pairs from the Italian Twin Registry (average age 45.0 ± 13.7 years) underwent TCCS and risk factor assessment. We examined CW morphology and recorded peak systolic velocity (PSV), end-diastolic velocity (EDV) and pulsatility index (PI)...
April 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29674522/smoking-and-risk-of-ischemic-stroke-in-young-men
#18
Janina Markidan, John W Cole, Carolyn A Cronin, Jose G Merino, Michael S Phipps, Marcella A Wozniak, Steven J Kittner
BACKGROUND AND PURPOSE: There is a strong dose-response relationship between smoking and risk of ischemic stroke in young women, but there are few data examining this association in young men. We examined the dose-response relationship between the quantity of cigarettes smoked and the odds of developing an ischemic stroke in men under age 50 years. METHODS: The Stroke Prevention in Young Men Study is a population-based case-control study of risk factors for ischemic stroke in men ages 15 to 49 years...
April 19, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29674486/physical-work-exposure-chronic-musculoskeletal-pain-and-risk-of-insomnia-longitudinal-data-from-the-hunt-study-norway
#19
Eivind Schjelderup Skarpsno, Tom Ivar Lund Nilsen, Trond Sand, Knut Hagen, Paul Jarle Mork
OBJECTIVES: To prospectively investigate (i) the association of physical work demands and work-related physical fatigue with risk of insomnia symptoms and (ii) if these associations are influenced by chronic musculoskeletal pain. METHODS: Prospective study on a working population of 8563 women and 7598 men participating in the Nord-Trøndelag Health Study (Norway) who reported no insomnia at baseline in 1995-1997. Occurrence of insomnia symptoms was assessed at follow-up in 2006-2008...
April 19, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29674371/automation-of-ct-based-haemorrhagic-stroke-assessment-for-improved-clinical-outcomes-study-protocol-and-design
#20
Betty Chinda, George Medvedev, William Siu, Martin Ester, Ali Arab, Tao Gu, Sylvain Moreno, Ryan C N D'Arcy, Xiaowei Song
INTRODUCTION: Haemorrhagic stroke is of significant healthcare concern due to its association with high mortality and lasting impact on the survivors' quality of life. Treatment decisions and clinical outcomes depend strongly on the size, spread and location of the haematoma. Non-contrast CT (NCCT) is the primary neuroimaging modality for haematoma assessment in haemorrhagic stroke diagnosis. Current procedures do not allow convenient NCCT-based haemorrhage volume calculation in clinical settings, while research-based approaches are yet to be tested for clinical utility; there is a demonstrated need for developing effective solutions...
April 19, 2018: BMJ Open
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