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https://www.readbyqxmd.com/read/29458155/determining-risk-of-colorectal-cancer-and-starting-age-of-screening-based-on-lifestyle-environmental-and-genetic-factors
#1
Jihyoun Jeon, Mengmeng Du, Robert E Schoen, Michael Hoffmeister, Polly A Newcomb, Sonja I Berndt, Bette Caan, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Graham G Giles, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Eric J Jacobs, Li Li, Yi Lin, Loïc Le Marchand, John D Potter, Flora Qu, Stephanie A Bien, Niha Zubair, Robert J Macinnis, Daniel D Buchanan, John L Hopper, Yin Cao, Reiko Nishihara, Gad Rennert, Martha L Slattery, Duncan C Thomas, Michael O Woods, Ross L Prentice, Stephen B Gruber, Yingye Zheng, Hermann Brenner, Richard B Hayes, Emily White, Ulrike Peters, Li Hsu
BACKGROUND & AIMS: Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors. We developed models to determine risk of CRC, based on lifestyle and environmental factors and genetic variants, and to identify an optimal age to begin screening. METHODS: We collected data from 9748 CRC cases and 10,590 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colorectal Transdisciplinary study, from 1992 through 2005...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29457751/intra-and-inter-fraction-uncertainties-during-igrt-for-wilms-tumor
#2
Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cees P van de Ven, Marry M van den Heuvel-Eibrink, Bas W Raaymakers
BACKGROUND AND PURPOSE: To assess intra- and inter-fraction motion uncertainties, due to displacements of the tumor bed (TB) and organs at risk (OAR), as well as intra- and inter-fraction patient set-up uncertainties, due to positioning variations, during image-guided radiation therapy (IGRT) in children with Wilms' tumor. MATERIAL AND METHODS: Four-dimensional computed tomography (4D-CT) and daily pre- and post-treatment cone-beam CT (CBCT)-scans of 15 patients (average 4, range 1-8 years) undergoing flank irradiation after nephrectomy were analyzed...
February 19, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29457392/-analysis-on-the-occult-blood-loss-after-unicompartment-knee-arthroplasty
#3
Zhan-Feng Zhang, Ji-Kang Min, Dan Wang, Jian-Ming Zhong, Heng Li
OBJECTIVE: To calculate the volume of occult blood loss after unicompartment knee arthroplasty(UKA), and analyze its influential factors by comparing with total knee arthroplasty. METHODS: A retrospective study of 130 cases from July 2012 to July 2015 were enrolled, of which and 65 cases were UKA, and 65 cases were TKA. In UKA group there were 27 males and 38 females, and the mean age was (62.3±4.3) years old (ranged, 50 to 82 years old). There were 14 cases older than 70 years old, while 51 cases among 50 to 70 years old...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457391/-analysis-on-related-factors-of-perioperative-total-blood-loss-in-unilateral-total-hip-arthroplasty
#4
Hong Yang, Xi-Bin Li, Jie Tan, Hao Li, Yin-Chu Shao, Feng Shuang
OBJECTIVE: To investigate the influential factors of total blood loss during unilateral artificial total hip arthroplasty (THA). METHODS: From January 2014 to July 2016, 131 patients undergwent primary unilateral total hip arthroplasty, including 55 males and 76 females, ranging in age from 40 to 89 years old, with an average of 64.5 years old. The data of patients with unilateral total hip arthroplasty were collected, and the data of hemodynamics, coagulation function, hemoglobin and hematocrit values were recorded according to the observation data...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457355/visceral-obesity-is-a-significant-risk-factor-for-incisional-hernia-after-laparoscopic-colorectal-surgery-a-single-center-review
#5
Masateru Yamamoto, Yuji Takakura, Satoshi Ikeda, Toshiyuki Itamoto, Takashi Urushihara, Hiroyuki Egi
INTRODUCTION: Although laparoscopic surgery uses relatively small incisions, incisional hernia after surgery is not uncommon. However, the incidence of incisional hernia and its risk factors are not well known. The purpose of our study was to investigate risk factors for incisional hernia after laparoscopic colorectal cancer surgery. METHODS: The study group consisted of 212 patients who underwent laparoscopic colorectal cancer surgery at Hiroshima Prefectural Hospital between November 2008 and October 2013...
February 19, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29457332/association-of-visit-to-visit-blood-pressure-variability-with-the-risk-of-all-cause-mortality-and-cardiovascular-events-in-general-population
#6
Liye Dai, Lu Song, Xiaoli Li, Yuling Yang, Xiaoming Zheng, Yuntao Wu, Chunhui Li, Hualing Zhao, Yilong Wang, Shouling Wu, Yongjun Wang
The association between blood pressure variability (BPV) and the risk of all-cause mortality and cardiovascular diseases (CVD) is not well understood. The Kailuan study is a prospective longitudinal cohort study on cerebrovascular events and cardiovascular factors. In this study, resting blood pressure was measured at baseline and every 2 years from 2006 to 2007. BPV is mainly defined as the coefficient of variation (CV). Hazard ratio (HR), with 95% confidence intervals (CI) was calculated using Cox regression model...
February 19, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29457225/aperture-generation-based-on-threshold-segmentation-for-intensity-modulated-radiotherapy-treatment-planning
#7
Jie Yang, Zhiguo Gui, Liyuan Zhang, Pengcheng Zhang
PURPOSE: To reduce computation and decrease planning time with little or no loss in plan quality compared to the column-generation-based (cg) method, a simple method of aperture generation based on threshold segmentation (agts) is proposed. METHODS: The proposed agts strategy consists of two steps. First, a fuzzy controller is used for noise cancellation; then, new apertures are added using the threshold segmentation algorithm. We tested the proposed method on seven prostate tumor cases using the computational environment for radiotherapy research algorithms for the dose calculations and compared the results with those obtained by generating the plan aperture using the cg method...
February 19, 2018: Medical Physics
https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#8
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456888/an-observational-study-on-risk-of-secondary-cancers-in-chronic-myeloid-leukemia-patients-in-the-tki-era-in-the-united-states
#9
Vivek Kumar, Mohit Garg, Neha Chaudhary, Abhinav Binod Chandra
Introduction: The treatment with tyrosine kinase inhibitors (TKIs) has drastically improved the outcome of chronic myeloid leukemia (CML) patients. This study was conducted to examine the risk of secondary cancers (SCs) in the CML patients who were diagnosed and treated in the TKI era in the United States. Methods: The surveillance epidemiology and end results (SEER) database was used to identify CML patients who were diagnosed and received treatment during January 2002-December 2014...
2018: PeerJ
https://www.readbyqxmd.com/read/29456681/analysis-of-related-factors-of-surgical-treatment-effect-on-215-patients-with-laryngeal-cancer
#10
Qiong Zhang, Ying Xiong, Ling Lin, Kun Yuan
This study investigated the factors affecting the surgical treatment effect on patients with laryngeal cancer. The clinical data (including the sex, age, smoking index, drinking, primary tumor site, tumor (T) stage, lymph nodes (N) stage, tumor differentiation degree, tumor diameter, surgical method, lymph node metastasis and cervical lymph node dissection) of 215 patients with laryngeal cancer in The Central Hospital of Wuhan were analyzed retrospectively; the survival rate was calculated using the Kaplan-Meier method; log-rank test was used for single-factor analysis, while Cox proportional hazard regression model was used for multiple-factor analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456582/assessing-the-accuracy-of-ultrasound-estimation-of-gestational-age-during-routine-antenatal-care-in-in-vitro-fertilization-ivf-pregnancies
#11
Bridget Knight, Aaron Brereton, Roy J Powell, Helen Liversedge
Introduction: In the UK an accurate gestational age is confirmed by ultrasound measured foetal crown rump length (CRL) at 11 + 2-14 + 1 weeks of gestation. The currently recommended Robinson and Fleming crown rump length reference chart was develop in 1975. Advances in ultrasound technology and standardized crown rump length measurement training could mean this is now out of date. Our study aimed to assess its accuracy in current routine antenatal care. Methods: Retrospective data from 178 IVF pregnancies seen for routine antenatal care at a UK Regional Maternity Unit between 1 January 2006 and 1 January 2016 was retrieved...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29456424/diabetes-risk-assessment-in-latinas-effectiveness-of-a-brief-diabetes-risk-questionnaire-for-detecting-prediabetes-in-a-community-based-sample
#12
Adam B Scanlan, Catarina M Maia, Alberly Perez, Carol J Homko, Matthew J O'Brien
Objective: Numerous validated questionnaires use self-reported data to quantify individuals' risk of having diabetes or developing it in the future. Evaluations of these tools have primarily used nationally representative data, limiting their application in clinical and community settings. This analysis tested the effectiveness of the American Diabetes Association (ADA) risk questionnaire for identifying prediabetes in a community-based sample of Latinas. Methods: Data were collected using the ADA risk questionnaire and assessing A1C...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456173/-failure-mode-and-effects-analysis-to-improve-quality-in-clinical-trials
#13
M Mañes-Sevilla, M B Marzal-Alfaro, R Romero Jiménez, A Herranz-Alonso, M N Sanchez Fresneda, J Benedi Gonzalez, M Sanjurjo-Sáez
INTRODUCTION: The failure mode and effects analysis (FMEA) has been used as a tool in risk management and quality improvement. The objective of this study is to identify the weaknesses in processes in the clinical trials area, of a Pharmacy Department (PD) with great research activity, in order to improve the safety of the usual procedures. METHODS: A multidisciplinary team was created to analyse each of the critical points, identified as possible failure modes, in the development of clinical trial in the PD...
February 15, 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29456120/bladder-debris-on-ultrasound-as-a-predictor-for-positive-urine-culture-in-a-pediatric-population
#14
Scott M Stevenson, Glen A Lau, William C Andolsek, Angela P Presson, Patrick C Cartwright
INTRODUCTION: Debris within the bladder is commonly seen on ultrasound. The etiology of bladder debris is varied and the likelihood that urinary debris represents positive urine culture is under investigation. We hypothesize that bladder debris will increase the likelihood that a urine culture is positive compared to those without bladder debris. METHODS: We performed a retrospective review on children aged 0-17 years who had a voiding cystourethrogram with a catheterized urinalysis or urine culture, and who also had a renal and bladder ultrasound up to 1 week prior, the day of, or up to 2 days after their urine studies...
February 3, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29455743/patience-moderates-the-class-cleavage-in-demand-for-redistribution
#15
Austin Horng-En Wang
Previous studies on class voting have yielded mixed results linking income and demand for redistribution. Why do some poor people oppose redistribution, while some rich people support it? This article argues that an individual's level of patience, an important personal characteristic that influences how people calculate immediate and distinct outcomes, may moderate the effect of class on redistributive preference. In a one-shot game, redistribution between the rich and the poor is zero sum. When people extend their time horizons, however, the poor see the possibility of upward mobility, while the rich emphasize future losses, such as unemployment and economic instability...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29455548/the-effects-of-smoking-on-neutrophil-lymphocyte-platelet-lymphocyte-ratios
#16
F Gumus, I Solak, M A Eryilmaz
OBJECTIVE: The aim of this study was to compare the Neutrophil to Lymphocyte ratio (NLR), Platelet to Lymphocyte ratio (PLR) and Mean Platelet Volume to Platelet (MPV/Plt) ratio of smokers and non-smokers. METHODS: Two hundred smokers and two hundred non-smoking healthy volunteers were enrolled in this study. Sociodemographic data and hematologic parameters of all patients were recorded. NLR, PLR and MPV/Plt ratios were calculated. RESULTS: The mean age of the case group was 35...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455425/the-risk-of-type-2-diabetes-mellitus-according-to-the-categories-of-body-mass-index-the-korean-genome-and-epidemiology-study-koges
#17
Ju Young Jung, Sung Keun Park, Chang Mo Oh, Jae-Hong Ryoo, Joong-Myung Choi, Young Joon Choi
AIMS: Obesity is an established risk factor for type 2 diabetes mellitus (T2DM). However, there is limited information on the pattern of relationship between the risk for T2DM and body mass index (BMI) categories including underweight and overweight. Thus, this study was to evaluate the risk of T2DM according to BMI categories defined by Asian-specific cutoff of BMI. METHODS: 7660 non-diabetic Koreans were grouped into five BMI categories (underweight, normal, overweight, obese and severe obese) defined by Asian-specific cutoff of BMI and followed up for 10 years to monitor the development of T2DM...
February 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29455368/sepsis-calculator-implementation-reduces-empiric-antibiotics-for-suspected-early-onset-sepsis
#18
Niek B Achten, J Wendelien Dorigo-Zetsma, Paul D van der Linden, Monique van Brakel, Frans B Plötz
Significant overtreatment with antibiotics for suspected early onset sepsis (EOS) constitutes a persisting clinical problem, generating unnecessary risks, harms, and costs for many newborns. We aimed to study feasibility and impact of a sepsis calculator to help guide antibiotic for suspected EOS in a European setting. In this single-center study, the sepsis calculator was implemented as an addition to and in accordance with existing protocols. One thousand eight hundred seventy-seven newborns ≥ 35 weeks of gestational age were prospectively evaluated; an analogous retrospective control group (n = 2076) was used for impact analysis...
February 18, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29455356/a-novel-electrocatalytic-approach-for-effective-degradation-of-rh-b-in-water-using-carbon-nanotubes-and-agarose
#19
Haiyang Liu, Miao Ren, Zhaocheng Zhang, Jiao Qu, Ying Ma, Nan Lu
Carbon nanotubes (CNTs)/agarose (AG) membrane on the ITO (indium tin oxide) conductive glass, with high efficiency of electrocatalytic degradation for rhodamine B (Rh-B) in water, was prepared using an easy and green method. The prepared CNTs/AG membrane was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive spectra (EDS), infrared spectroscopy (IR), and electrochemical impedance spectroscopy (EIS). The results revealed that CNTs were dispersed in the AG membrane...
February 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29455268/family-history-of-cancer-in-first-degree-relatives-and-risk-of-gastric-cancer-and-its-precursors-in-a-western-population
#20
Minkyo Song, M Constanza Camargo, Stephanie J Weinstein, Ana F Best, Satu Männistö, Demetrius Albanes, Charles S Rabkin
BACKGROUND: Family history may inform risks of gastric cancer and preneoplastic lesions. METHODS: We examined associations with history of cancer in first-degree relatives for 307 incident gastric cancer cases among 20,720 male smokers in a prospective study in Finland. Cox regression was used to calculate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI). Logistic regression was used to estimate odds ratios (OR) and 95% CIs for low serum pepsinogen, a marker of gastric atrophy...
February 17, 2018: Gastric Cancer
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