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SIRS in adolescents

Jenny N Poynter, Michaela Richardson, Michelle Roesler, Mark Krailo, James F Amatruda, A Lindsay Frazier
BACKGROUND: Studies of family history of cancer in paediatric germ cell tumours (GCTs) are few, and none has had sufficient sample size to specifically evaluate family history of GCT. METHODS: We utilised family history data from a paediatric GCT study to calculate standardised incidence ratios (SIR) for GCT and other cancers using age- and sex-specific incidence rates from the SEER Program. RESULTS: This analysis included 7998 relatives of paediatric GCT probands...
January 2018: British Journal of Cancer
Waleed Al-Mahdi, Mazen M Ibrahim, David A Spiegel, Alexandre Arkader, Michael Nance, Keith Baldwin
BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a well-recognized phenomenon in adult trauma populations. The "initial hit" of the traumatic event is often coupled with a systemic immune response characterized by changes in vital signs and laboratory indicators. A "second hit" from surgery during this time frame often results in acute lung injury, along with deterioration of the patient's clinical condition. We hypothesized that children and adolescents would experience SIRS physiology, but would not experience adult respiratory distress syndrome (ARDS) or "second hit" related death to the extent seen in the adult populations...
October 9, 2017: Journal of Pediatric Orthopedics
Johanne Marie Holst, Erzsébet Horváth-Puhó, Rikke Beck Jensen, Mariane Rix, Kurt Kristensen, Niels Thomas Hertel, Olaf M Dekkers, Henrik Toft Sørensen, Anders Juul, Jens Otto L Jørgensen
OBJECTIVE: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young patients are very limited. We therefore examined the incidence, prevalence and hospital morbidity of CS in children and adolescents. DESIGN: In a nationwide cohort study, we included all Danish citizens aged 0-20 years from 1977 to 2012. Data were obtained from the Danish National Patient Registry using the International Classification of Diseases (ICD) codes and the Danish Civil Registration System...
May 2017: European Journal of Endocrinology
C Salerno, P Berchialla, L A Palin, E Barasolo, P G Fossale, P Marciani
INTRODUCTION: This study of the geographical incidence on the oncological mortality in young age (0-44 years) in the City of Vercelli, was aimed to address the concerns of the population and the request of municipal administrators. A detailed and sophisticated study for a City of medium-small size is due for the presence of various sources of pressure, such as a MSW incinerator just a few kilometres from the city and an intensive agricultural activity that characterizes the entire area...
January 2017: Annali di Igiene: Medicina Preventiva e di Comunità
Jamil S Syed, Kevin A Nguyen, Charlotte Q Wu, Nicholas G Cost, Mohummad M Siddiqui, Adam B Hittelman, Brian Shuch
PURPOSE: Renal cell carcinoma (RCC) represents a small proportion of renal malignancies early in life. Distinguishing RCC from other malignancies is important as treatment strategies may differ. We analyze the Surveillance Epidemiology, and End Results (SEER) database to identify predictive factors of RCC in the pediatric population with renal tumors. METHODS: We queried SEER to identify patients from ages 0 to 19 diagnosed with a renal malignancy between 1973 and 2013...
May 2017: Pediatric Blood & Cancer
Teresa Sir-Petermann, Bárbara Echiburú, Nicolás Crisosto, Manuel Maliqueo, Francisco Pérez Bravo
Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine metabolic disorder and is presently considered a family pathology. It is associated with obesity, insulin resistance and metabolic syndrome. Racial, ethnic and environmental factors may be important in determining the clinical manifestations of this syndrome. Polycystic ovary syndrome is an exclusion diagnosis and, therefore, should be distinguished from the physiological changes typical for the age and from other hyperandrogenic disorders. Early diagnosis is important since this syndrome is associated with reproductive, oncologic and metabolic risks...
2016: Current Pharmaceutical Design
Swaantje Barth, Jenny Schlichtiger, Barbara Hartmann, Betty Bisdorff, Hartmut Michels, Katja Radon, Boris Hügle, Linda Walsh, Johannes-Peter Haas
OBJECTIVES: In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS: A retrospective single-center hospital-based cohort study was performed using data on the JIA patients treated between 1952 and 2010 at the German Center for Pediatric and Adolescent Rheumatology (GCPAR) (Garmisch-Partenkirchen, Germany)...
January 2017: Modern Rheumatology
Evgenia Ostroumova, Maureen Hatch, Alina Brenner, Eldar Nadyrov, Ilya Veyalkin, Olga Polyanskaya, Vasilina Yauseyenka, Semion Polyakov, Leonid Levin, Lydia Zablotska, Alexander Rozhko, Kiyohiko Mabuchi
BACKGROUND: While an increased risk of thyroid cancer from post-Chernobyl exposure to Iodine-131 (I-131) in children and adolescents has been well-documented, risks of other cancers or leukemia as a result of residence in radioactively contaminated areas remain uncertain. METHODS: We studied non-thyroid cancer incidence in a cohort of about 12,000 individuals from Belarus exposed under age of 18 years to Chernobyl fallout (median age at the time of Chernobyl accident of 7...
May 2016: Environmental Research
Stephan Collishaw, Gemma Hammerton, Liam Mahedy, Ruth Sellers, Michael J Owen, Nicholas Craddock, Ajay K Thapar, Gordon T Harold, Frances Rice, Anita Thapar
BACKGROUND: Young people whose parents have depression have a greatly increased risk of developing a psychiatric disorder, but poor outcomes are not inevitable. Identification of the contributors to mental health resilience in young people at high familial risk is an internationally recognised priority. Our objectives were to identify protective factors that predict sustained good mental health in adolescents with a parent with depression and to test whether these contribute beyond what is explained by parent illness severity...
January 2016: Lancet Psychiatry
Jean S Lee, Steven G DuBois, Peter F Coccia, Archie Bleyer, Rebecca L Olin, Robert E Goldsby
BACKGROUND: The authors describe the incidence and characteristics of secondary malignant neoplasms (SMNs) in adolescent and young adult (AYA) cancer survivors compared with those in younger and older cancer survivors. METHODS: Children aged ≤ 14 years, AYAs aged 15 to 39, and older adults aged ≥ 40 years at the time of primary diagnosis who were reported as cancer survivors in the Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2011 were compared in this population-based analysis...
January 1, 2016: Cancer
Onyekachi Henry Ogbonna, Yonette Paul, Hasan Nabhani, Adriana Medina
First described by Sir Nicholas Brodie in 1832, Brodie's abscess is a localized subacute or chronic infection of the bone, typically seen in the metaphases of long bones in children and adolescents. The diagnosis can prove to be enigmatic due to absence of clinical signs and symptoms of systemic disease. We report a very interesting case of Brodie's abscess masquerading as sickle cell vasoocclusive crisis in a 20-year-old female with sickle cell disease and review the literature.
2015: Case Reports in Medicine
Felipe Pollak, Verónica Araya, Alejandra Lanas, Jorge Sapunar, Marco Arrese, Carmen Gloria Aylwin, Carmen Gloria Bezanilla, Elena Carrasco, Fernando Carrasco, Ethel Codner, Erik Díaz, Pilar Durruty, José Galgani, Hernán García, Rodolfo Lahsen, Claudio Liberman, Gloria López, Alberto Maíz, Verónica Mujica, Jaime Poniachik, Teresa Sir, Néstor Soto, Juan Valderas, Paulina Villaseca, Carlos Zavala
Insulin resistance is a prevalent condition commonly associated with unhealthy lifestyles. It affects several metabolic pathways, increasing risk of abnormalities at different organ levels. Thus, diverse medical specialties should be involved in its diagnosis and treatment. With the purpose of unifying criteria about this condition, a scientific-based consensus was elaborated. A questionnaire including the most important topics such as cardio-metabolic risk, non-alcoholic fatty liver disease and polycystic ovary syndrome, was designed and sent to national experts...
May 2015: Revista Médica de Chile
Claudio Villarroel, Patricia López, Paulina M Merino, Germán Iñiguez, Teresa Sir-Petermann, Ethel Codner
We evaluated the association of hirsutism and oligomenorrhea (persistent menstrual cycles > 45 days) as screening criteria for the detection of biochemical hyperandrogenism (BH) and polycystic ovaries (PCOM) during adolescence and determined which androgens, granulosa cell hormone, ultrasonographic parameters have the best association with polycystic ovary syndrome (PCOS). Hirsute girls with oligomenorrhea (N = 26 Hirs/Oligo group) and non-hirsute girls with regular cycles (N = 63, C group) were studied...
2015: Gynecological Endocrinology
Dimitrios Nasioudis, Ilana Ramer, Giovanni Sisti, Massimiliano Fambrini
STUDY OBJECTIVE: To calculate the incidence of second primary tumors (SPTs) in patients previously diagnosed with malignant ovarian tumors in childhood and adolescence. This is an area of interest given the high survival rate and, thus, the long disease-free period that these patients face. DESIGN AND PARTICIPANTS: We conducted a retrospective study following a cohort of patients between 1973 and 2011. Using the National Cancer Institute's Surveillance, Epidemiology and End-Result (SEER) database, we identified patients with an ovarian malignant tumor diagnosed at 19 years of age or younger...
December 2015: Journal of Pediatric and Adolescent Gynecology
Wolfgang Dörffel, Marianne Riepenhausenl, Heike Lüders, Jürgen Brämswig, Günther Schellong
BACKGROUND: About 155 persons under age 18 develop Hodgkin's lymphoma (HL) in Germany every year. More than 90% survive at least 20 years. They may, however, suffer from late sequelae of treatment, including secondary malignant neoplasia (SMN). METHODS: 2548 patients from the German, Austrian, and Swiss pediatric Hodgkin's lymphoma studies that were conducted over the period 1978-2002 were asked every 2-3 years about possible late sequelae of treatment, either directly or through their physicians...
May 1, 2015: Deutsches Ärzteblatt International
Petra Temming, Anja Viehmann, Marina Arendt, Lewin Eisele, Claudia Spix, Norbert Bornfeld, Wolfgang Sauerwein, Karl-Heinz Jöckel, Dietmar R Lohmann
BACKGROUND: Children with retinoblastoma carry a high risk to develop second primary malignancies in childhood and adolescence. This study characterizes the type of pediatric second primary malignancies after retinoblastoma treatment and investigates the impact of different treatment strategies and prognostic factors at presentation. PROCEDURE: All national patients treated for retinoblastoma at the German referral center with a current age of 6-27 years were invited to participate in a study to characterize late effects...
October 2015: Pediatric Blood & Cancer
Jean S Lee, Benjamin Padilla, Steven G DuBois, Aris Oates, John Boscardin, Robert E Goldsby
BACKGROUND: The goal of this study was to describe the incidence, characteristics, and outcomes of secondary malignant neoplasms (SMN) in survivors of Wilms tumor. PROCEDURES: Patients who were 0-20 years of age at time of primary diagnosis with Wilms tumor and reported to the Surveillance, Epidemiology, and End Results [SEER] program between 1973 and 2011 were eligible for inclusion in the cohort. We used competing risks methods to estimate the cumulative incidence of SMNs and assess contributing factors for developing SMN...
July 2015: Pediatric Blood & Cancer
Huey-Ling Chiang, Chia-Jen Liu, Yu-Wen Hu, San-Chi Chen, Li-Yu Hu, Cheng-Che Shen, Chiu-Mei Yeh, Tzeng-Ji Chen, Susan Shur-Fen Gau
OBJECTIVES: To investigate whether individuals with autism have an increased risk for cancer relative to the general population. STUDY DESIGN: We enrolled patients with autistic disorder from the Taiwan National Health Insurance database in years 1997-2011. A total of 8438 patients diagnosed with autism were retrieved from the Registry for Catastrophic Illness Patients database. The diagnosis of cancers was also based on the certificate of catastrophic illness, which requires histological confirmation...
February 2015: Journal of Pediatrics
Jean S Lee, Steven G DuBois, W John Boscardin, Rosanna L Wustrack, Robert E Goldsby
BACKGROUND: As patients with osteosarcoma become long-term survivors, increasing attention has turned to the burden of late effects. The goal of the current study was to describe the incidence, characteristics, and outcomes of secondary malignant neoplasms (SMNs) in this population. METHODS: Patients aged birth to 40 years at time of primary diagnosis with osteosarcoma and reported to the Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2010 were eligible for inclusion in the cohort...
December 15, 2014: Cancer
Corey Cutler, Brent Logan, Ryotaro Nakamura, Laura Johnston, Sung Choi, David Porter, William J Hogan, Marcelo Pasquini, Margaret L MacMillan, Jack W Hsu, Edmund K Waller, Stephan Grupp, Philip McCarthy, Juan Wu, Zhen-Huan Hu, Shelly L Carter, Mary M Horowitz, Joseph H Antin
Grades 2-4 acute graft-versus-host disease (GVHD) occurs in approximately 35% of matched, related donor (MRD) allogeneic hematopoietic cell transplantation (HCT) recipients. We sought to determine if the combination of tacrolimus and sirolimus (Tac/Sir) was more effective than tacrolimus and methotrexate (Tac/Mtx) in preventing acute GVHD and early mortality after allogeneic MRD HCT in a phase 3, multicenter trial. The primary end point of the trial was to compare 114-day grades 2-4 acute GVHD-free survival using an intention-to-treat analysis of 304 randomized subjects...
August 21, 2014: Blood
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