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https://www.readbyqxmd.com/read/27931634/complications-of-endoscopic-polypectomy-endoscopic-mucosal-resection-and-endoscopic-submucosal-dissection-in-the-colon
#1
REVIEW
Michael X Ma, Michael J Bourke
Endoscopic resection (ER), including endoscopic polypectomy (EP), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are used to remove superficial neoplasms from the colon. Snare resection is used for EP and EMR, whereas endoscopic knives are used to perform dissection in the submucosal space in ESD. 80-90% colonic polyps are <10 millimetres (mm) and are effectively managed by conventional EP. Increasingly cold snare polypectomy is preferred. Large laterally spreading lesions (LSLs) and sessile polyps ≥20 mm are primarily removed by EMR...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27931050/improved-detection-of-right-colon-adenomas-with-additional-retroflexion-following-two-forward-view-examinations-a-prospective-study
#2
Hyun Seok Lee, Seong Woo Jeon, Hye Yoon Park, Seong Jae Yeo
Background and study aims Colonoscopy in the right colon is less effective than in the left colon in screening for colorectal cancer. The aim of this study was to prospectively evaluate the diagnostic value of retroflexion in the right colon. Patients and methods A total of 1020 patients undergoing screening or surveillance colonoscopy were enrolled. After the first cecal intubation, the scope was withdrawn from the cecum to the hepatic flexure in the standard forward view and all identified polyps were resected...
December 8, 2016: Endoscopy
https://www.readbyqxmd.com/read/27930579/molecular-characteristics-of-colorectal-serrated-polyps-and-hyperplastic-polyps-a-strobe-compliant-article
#3
Otgontuya Sambuudash, Hee Man Kim, Hannah Jo, Hyun Sik Kim, Kyong Joo Lee, Hong Jun Park, Jae Woo Kim, Mee Yon Cho, Hyun-Soo Kim
The serrated neoplasia pathway of colorectal carcinogenesis is characterized by BRAF mutation and aberrant DNA methylation, which have not been reported on Korean patients. The aim of this study was to investigate BRAF mutation and DNA methylation in colorectal serrated polyps and the right colon.Between 2005 and 2013, 146 colon polyps (47 tubular adenomas [TAs], 53 traditional serrated adenomas [TSAs], 17 sessile serrated adenomas/polyps [SSAs], and 29 hyperplastic polyps in the proximal colon [PHPs]) were collected from patients...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27926694/involvement-of-activated-cdc42-kinase1-in-colitis-and-colorectal-neoplasms
#4
Chaolan Lv, Hongxiang Gu, Xinmei Zhao, Liyun Huang, Sanxi Zhou, Fachao Zhi
BACKGROUND Activated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity. MATERIAL AND METHODS A total of 250 individuals who underwent total colonoscopy were collected randomly from January 2007 to May 2013 in Nanfang Hospital, Guangzhou, China...
December 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27925331/the-mirna-landscape-of-colorectal-polyps
#5
Martha L Slattery, Jennifer S Herrick, Roger K Wolff, Lila E Mullany, John R Stevens, Wade Samowitz
The genomic landscape of adenomas and polyps may help define disease pathways. Expression of miRNAs in adenomas and polyps may importantly contribute to these pathways. We evaluated miRNA expression in 293 polyp-normal colorectal mucosa pairs. Polyps were classified as either adenomatous polyp (AD), hyperplastic polyp (HP), or sessile serrated polyp (SSP). We compared these miRNA expression profiles in polyps to miRNA expression in microsatellite unstable (MSI) and stable (MSS) tumors. A False Discovery Rate (FDR) of 0...
December 7, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27924065/the-more-the-messier-centrosome-amplification-as-a-novel-biomarker-for-personalized-treatment-of-colorectal-cancers
#6
REVIEW
Monica M Mahathre, Padmashree Cg Rida, Ritu Aneja
Colon cancer is currently the third most common cancer and second most fatal cancer in the United States, resulting in approximately 600,000 deaths annually. Though colorectal cancer death rates are decreasing by about 3% every year, disease outcomes could be substantially improved with more research into the drivers of colon carcinogenesis, the determinants of aggressiveness in colorectal cancer and the identification of biomarkers that could enable choice of more optimal treatments. Colon carcinogenesis is notably a slow process that can take decades...
November 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27920846/three-dimensional-computed-tomography-rendering-of-pedunculated-colon-polyp-new-clapper-bell-sign-pedunculated-polyp-at-3d-computed-tomography
#7
Marco Di Serafino, Rosa Severino, Fabia Laviani, Domenico Maroscia
The incidental detection of a tubulovillous adenoma at a contrast-enhanced computed tomography (CECT) with nondedicated protocol, performed in emergency conditions, is an uncommon finding. We report a case of a woman presenting with a subocclusive episode. A CECT scan was performed, and a pedunculated polyp could be appreciated at 3D-reconstruction images. A particular depiction of pedunculus of the polypoid lesion, resemble a clapper-bell, could help to define the vegetating lesion at the volume-rendering reconstruction images...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920699/asymptomatic-multiple-lymphomatous-polyposis-identified-during-staging-bidirectional-endoscopy-of-mantle-cell-lymphoma
#8
Sonja P Dawsey, Jason A Gregory, Alexander W Brown, Frances J Jones
Multiple lymphomatous polyposis (MLP) as an extranodal manifestation of mantle cell lymphoma (MCL) in the gastrointestinal tract is rare and not often reported in the literature. We describe the case of a 63-year-old female with asymptomatic MLP found during staging bidirectional endoscopy of MCL. The patient presented only with dyspnea, but was found on physical exam to have diffuse lymphadenopathy, and subsequent positron emission tomography (PET) CT showed extensive lymph node adenopathy consistent with lymphoma...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27918709/spectral-photon-counting-ct-initial-experience-with-dual-contrast-agent-k-edge-colonography
#9
Daniela Muenzel, Daniel Bar-Ness, Ewald Roessl, Ira Blevis, Matthias Bartels, Alexander A Fingerle, Stefan Ruschke, Philippe Coulon, Heiner Daerr, Felix K Kopp, Bernhard Brendel, Axel Thran, Michal Rokni, Julia Herzen, Loic Boussel, Franz Pfeiffer, Roland Proksa, Ernst J Rummeny, Philippe Douek, Peter B Noël
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by using the characteristic k edge of gadolinium. Materials and Methods A custom-made colon phantom was filled with nonionic iodine-based contrast material, and a gadolinium-filled capsule representing a contrast material-enhanced polyp was positioned on the colon wall. The colon phantom was scanned with a preclinical spectral photon-counting CT system to obtain spectral and conventional data...
December 2, 2016: Radiology
https://www.readbyqxmd.com/read/27918452/light-dark-shifting-promotes-alcohol-induced-colon-carcinogenesis-possible-role-of-intestinal-inflammatory-milieu-and-microbiota
#10
Faraz Bishehsari, Abdulrahman Saadalla, Khashayarsha Khazaie, Phillip A Engen, Robin M Voigt, Brandon B Shetuni, Christopher Forsyth, Maliha Shaikh, Martha Hotz Vitaterna, Fred Turek, Ali Keshavarzian
BACKGROUND: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption-another modern life style habit-in promoting alcohol-associated CRC. METHOD: TS4Cre × adenomatous polyposis coli (APC)(lox468) mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27917224/rectal-inflammatory-fibroid-polyp-in-a-nigerian-case-report-brief-review-of-literature
#11
Oluyemi Aderemi, Awolola Nicholas
BACKGROUND: Inflammatory fibroid polyps are very unusual gastrointestinal tumours. Furthermore, their occurrence in the rectum is a rarity indeed. OBJECTIVE: To document this very rare pathologic entity in a patient from our region of Africa and highlight some pertinent clinical and pathologic aspects of the disease. CASE REPORT: We present a 59 year old Nigerian who had neither significant previous medical history nor current complaint and had a routine colonoscopy done...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27909808/clinical-validation-of-a-novel-urine-based-metabolomic-test-for-the-detection-of-colonic-polyps-on-chinese-population
#12
Lu Deng, Hong Fang, Victor K Tso, Yuanyuan Sun, Rae R Foshaug, Spencer C Krahn, Fen Zhang, Yujie Yan, Huilin Xu, David Chang, Yong Zhang, Richard N Fedorak
PURPOSE: Colorectal cancer is the fifth leading cause of cancer-related deaths in China. When detected early, with the removal of adenomatous polyps, precursors of colorectal cancer, it is preventable. The aim of this study was to evaluate a novel urine-based metabolomic diagnostic test for the detection of adenomatous polyps, PolypDx™, that was originally developed and validated using 1000 samples from Canadian Cohort, on Chinese population. METHODS: Prospective urine samples were collected from 1000 participants undergoing colonoscopy examination, from March 2013 to July 2014 at Minhang District, Shanghai Centre for Disease Control and Prevention...
December 1, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#13
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27896421/multiple-behavioral-factors-are-associated-with-occurrence-of-large-flat-colorectal-polyps
#14
Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Asmé Bilge, Jürgen Grüger, Jürgen Weers, Johannes Betge, Timo Gaiser, Georg Kähler, Matthias P Ebert, Sebastian Belle
PURPOSE: The prevalence of advanced dysplasia and synchronous lesions is particularly high in patients with large, flat colorectal polyps. However, the impact of lifestyle on the development of such polyps is poorly investigated. Hence, this study aims to identify associations between behavioral factors and the occurrence of large, flat colorectal polyps. METHODS: Behavioral factors were retrospectively analyzed in patients with large, flat polyps and control patients with at most one diminutive polyp...
November 28, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27893377/high-performance-cad-ctc-scheme-using-shape-index-multiscale-enhancement-filters-and-radiomic-features
#15
Yacheng Ren, Jingchen Ma, Junfeng Xiong, Lin Lu, Jun Zhao
OBJECTIVE: Computer-aided detection (CAD) systems for computed tomography colonography (CTC) can automatically detect colorectal polyps. The main problem of currently developed CAD-CTC systems is the numerous false positives (FPs) caused by the existence of complicated colon structures (e.g., haustral fold, residual fecal material, inflation tube, and ileocecal valve). This study proposes a CAD-CTC scheme using shape index, multiscale enhancement filters, and radiomic features to address the FP issue...
November 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27890867/obesity-related-digestive-diseases-and-their-pathophysiology
#16
REVIEW
Su Youn Nam
Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagus, esophageal cancer, colon polyp and cancer, nonalcoholic fatty liver disease, hepatitis C-related disease, hepatocellular carcinoma, gallstone, cholangiocarcinoma, and pancreatic cancer...
November 29, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27890264/selective-suppression-of-in-situ-proliferation-of-scyphozoan-polyps-by-biofouling
#17
Song Feng, Shi-Wei Wang, Guang-Tao Zhang, Song Sun, Fang Zhang
An increase in marine artificial constructions has been proposed as a major cause of jellyfish blooms, because these constructions provide additional substrates for organisms at the benthic stage (polyps), which proliferate asexually and release a large amount of free-swimming medusae. These hard surfaces are normally covered by fouling communities, the components of which have the potential to impede the proliferation of polyps. In this study, we report an in situ experiment of polyp survival of four large scyphozoan species found in East Asian marginal seas that were exposed to biofouling, a universal phenomenon occurring on marine artificial constructions...
November 24, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27889548/impact-of-physician-adherence-to-colonoscopy-surveillance-guidelines-on-interval-colon-cancer
#18
Jennifer Nayor, John R Saltzman, Emily J Campbell, Molly L Perencevich, Kunal Jajoo, James M Richter
BACKGROUND AND AIMS: Interval colorectal cancer (iCRC) incidence is the criterion standard benchmark for measuring the effectiveness of colonoscopy. Colonoscopy surveillance guidelines are designed to minimize iCRC cases. Our aims were to (1) describe characteristics of iCRC patients; and (2) assess if development of iCRC is related to colonoscopy surveillance guideline intervals. METHODS: We performed a retrospective cohort study of post-colonoscopy iCRC cases in a large healthcare system...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27884518/multi-target-stool-dna-test-clinical-performance-and-impact-on-yield-and-quality-of-colonoscopy-for-colorectal-cancer-screening
#19
David H Johnson, John B Kisiel, Kelli N Burger, Douglas W Mahoney, Mary E Devens, David A Ahlquist, Seth Sweetser
BACKGROUND & AIMS: Multi-target stool DNA testing (MT-sDNA) is now FDA-approved for average-risk CRC screening. Trials leading to its approval used blinded colonoscopy as the reference standard. In the post-approval screen setting, the clinical performance and impact of MT-sDNA on unblinded colonoscopy has not been described. We measured the impact that knowledge of a positive MT-sDNA test result has on colonoscopy yield and quality. METHODS: The unblinded group comprised all patients with positive MT-sDNA results on screening from 9/1/14-9/30/15 at a single tertiary center...
November 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27882202/computed-tomography-colonography-phantom-construction-validation-and-literature-review
#20
Lukas Lambert, Alena Lambertova, Jan Danes, Gabriela Grusova
BACKGROUND: Several dedicated computed tomography (CT) colonography phantoms have been described previously. OBJECTIVES: To compare their pros and cons and describe the construction of a dedicated phantom that can be easily manufactured. MATERIALS AND METHODS: We found 15 different phantom designs by literature search and compared their advantages and disadvantages based on their description and images. We tested various materials for density and mechanical properties and constructed a phantom from polypropylene pipes (30 mm and 50 mm in diameter, 52 cm in length)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
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