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https://www.readbyqxmd.com/read/28078114/colorectal-cancer-anatomic-distribution-patterns-remain-the-same-after-sessile-serrated-adenoma-polyp-considered-cancer-precursor-a-9-year-comparison-study-from-community-based-endoscopy-centers
#1
Juliana F Yang, Amy E Noffsinger, Deepak Agrawal, Qing-Hua Yang
BACKGROUND: The overall incidence of colorectal cancer (CRC) in the United States has steadily decreased. However, the incidence of right-sided CRC remains unchanged for the past two decades. The serrated neoplastic pathway (sessile serrated adenoma/polyp, SSA/P) has been considered an important pathway of colorectal carcinogenesis, especially in the right-sided CRC. The aim of this study was to compare CRC anatomic distribution patterns in a 9-year interval in the general population before and after SSA/P was recognized and treated as a CRC precursor...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28075483/detecting-apc-gene-mutations-in-familial-adenomatous-polyposis-fap
#2
Babi Ramesh Reddy Nallamilli, Madhuri Hegde
Hereditary forms of colorectal cancer (CRC) account for up to 5% of total cases. Familial adenomatous polyposis (FAP) is an autosomal dominant condition affecting nearly 1 in 5000 people and accounts for only about 1% of all CRCs. It is characterized by the progressive development of hundreds to thousands of adenomatous colon polyps. The gene associated with FAP (APC) contains 15 coding exons. The mutation spectrum of the APC gene is broad in that 87% of causative mutations are point mutations (including other sequence variants) and around 10% to 15% are intragenic deletions and duplications...
January 11, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/28069476/missed-adenomas-with-behind-folds-visualizing-colonoscopy-technologies-compared-with-standard-colonoscopy-a-pooled-analysis-of-3-randomized-back-to-back-tandem-colonoscopy-studies
#3
Eelco C Brand, Vincent K Dik, Martijn G H van Oijen, Peter D Siersema
BACKGROUND AND AIMS: The Third Eye Retroscope, Full Spectrum Endoscope (FUSE) and EndoRings device have been shown to reduce overall adenoma miss rates. We evaluated the characteristics of adenomas and patient subgroups for which these "behind folds visualizing" technologies mostly reduce adenoma miss rates. METHODS: Data of 3 multicenter randomized trials (NCT01044732; NCT01549535; NCT01955122) were combined. Patients underwent same-day, back-to-back tandem examinations with standard colonoscopy and Third Eye Retroscope, FUSE or EndoRings colonoscopy, respectively...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28065946/a-retrospective-study-of-clinico-pathological-characteristics-of-colonic-polyps-in-adults-seen-at-a-tertiary-care-centre
#4
Asim Qureshi, Zafar Ali, Asem Shalaby
OBJECTIVE: To analyse morphological types, location in the large bowel and demographic characteristics of colonic polyps. METHODS: The retrospective descriptive study was conducted at the Department of Pathology, Sultan Qaboos University Hospital, Muscat, Oman, and comprised biopsy specimens of colonic polyps from patients related to a two-year period from 2011 to 2012. Demographic data, types of polyps, anatomical location and grade of dysplasia were analysed. SPSS 20 was used for statistical analysis...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28064440/dietary-fibre-for-the-prevention-of-recurrent-colorectal-adenomas-and-carcinomas
#5
REVIEW
Yibo Yao, Tao Suo, Roland Andersson, Yongqing Cao, Chen Wang, Jingen Lu, Evelyne Chui
BACKGROUND: This is an update of the Cochrane review published in 2002.Colorectal cancer (CRC) is a major cause of morbidity and mortality in industrialised countries. Experimental evidence has supported the hypothesis that dietary fibre may protect against the development of CRC, although epidemiologic data have been inconclusive. OBJECTIVES: To assess the effect of dietary fibre on the recurrence of colorectal adenomatous polyps in people with a known history of adenomatous polyps and on the incidence of CRC compared to placebo...
January 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28054186/radiographic-capsule-based-system-for-non-cathartic-colorectal-cancer-screening
#6
Yoav Kimchy, Ronen Lifshitz, Shlomo Lewkowitz, Guiseppe Bertuccio, Nadir Arber, Nathan Gluck, Perry J Pickhardt
Many patients are reluctant to undergo optical colonoscopy for colorectal cancer screening. The Check-Cap colon imaging system is a non-invasive test that comprises an ingestible imaging capsule that emits and detects ultra-low-dose radiation. The capsule generates a 3D reconstruction of the colonic lumen for detection of polyps and cancer. Preliminary preclinical and clinical testing has demonstrated safety and feasibility. Mean radiation dose is estimated at 0.04 mSv. In conclusion, we describe a novel capsule-based, patient-friendly colorectal test that holds potential for non-invasive screening...
January 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28052292/evaluation-for-the-clinical-efficacy-of-colon-capsule-endoscopy-in-the-detection-of-laterally-spreading-tumors
#7
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
https://www.readbyqxmd.com/read/28045200/quality-of-colonoscopy-performed-in-rural-practice-experience-from-the-clinical-outcomes-research-initiative-and-the-oregon-rural-practice-based-research-network
#8
Jennifer L Holub, Cynthia Morris, Lyle J Fagnan, Judith R Logan, LeAnn C Michaels, David A Lieberman
PURPOSE: Colon cancer screening is effective. To complete screening in 80% of individuals over age 50 years by 2018 will require adequate colonoscopy capacity throughout the country, including rural areas, where colonoscopy providers may have less specialized training. Our aim was to study the quality of colonoscopy in rural settings. METHODS: The Clinical Outcomes Research Initiative (CORI) and the Oregon Rural Practice-based Research Network (ORPRN) collaborated to recruit Oregon rural practices to submit colonoscopy reports to CORI's National Endoscopic Database (NED)...
January 3, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28041973/prognostic-significance-of-stromal-grem1-expression-in-colorectal-cancer
#9
Bo Gun Jang, Hye Sung Kim, Weon Young Chang, Jeong Mo Bae, Hyeon Jeong Oh, Xianyu Wen, Seorin Jeong, Nam Yun Cho, Woo Ho Kim, Gyeong Hoon Kang
Cancer associated fibroblasts (CAFs) are the dominant cell population in the cancer stroma. Gremlin 1 (GREM1), an antagonist of the bone morphogenetic protein pathway, is expressed by CAFs in a variety of human cancers. However, its biological significance for cancer patients is largely unknown. We applied RNA in situ hybridization (ISH) to evaluate the prognostic value of stromal GREM1 expression in a large cohort of 670 colorectal cancers (CRCs). Overall GREM1 expression in CRCs was lower than that of the matched normal mucosa, and GREM1 expression had a strong positive correlation with BMI1 and inverse correlations with EPHB2 and OLFM4...
December 29, 2016: Human Pathology
https://www.readbyqxmd.com/read/28035253/colon-adenoma-features-and-their-impact-on-risk-of-future-advanced-adenomas-and-colorectal-cancer
#10
Audrey H Calderwood, Karen E Lasser, Hemant K Roy
AIM: To review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CRC)]. METHODS: We performed a literature search using the National Library of Medicine through PubMed from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma)...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28028382/fice-vs-narrow-band-imaging-for-in-vivo-histologic-diagnosis-of-polyps
#11
Cevher Akarsu, Nuri Alper Sahbaz, Ahmet Cem Dural, Mustafa Gokhan Unsal, Osman Kones, Ali Kocatas, Ilkay Halicioglu, Halil Alis
BACKGROUND AND OBJECTIVES: Gastrointestinal cancers are the most frequently occurring cancers worldwide. Diagnosis and removal of polyps during screening endoscopy decreases the prevalence of colon cancer and cancer-related mortality, and it is considered to be the gold standard in gastrointestinal system cancer prevention. Technological innovations in endoscopy have led to revolutionary developments in many areas. Flexible spectral imaging color enhancement (FICE) and narrow-band imaging (NBI) are forms of digital chromoendoscopy and enhance the endoscopic images without the need for a dye...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28025763/helicobacter-pylori-infection-is-an-independent-risk-factor-for-colonic-adenomatous-neoplasms
#12
Ji Hyung Nam, Chang Won Hong, Byung Chang Kim, Aesun Shin, Kum Hei Ryu, Bum Joon Park, Bun Kim, Dae Kyung Sohn, Kyung Su Han, Jeongseon Kim, Chan Wha Lee
PURPOSE: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase. METHODS: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs...
December 27, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28025471/-new-colonoscopy-devices-to-improve-colon-neoplasm-detection
#13
REVIEW
Sung Jae Shin
Early detection and removal of adenomatous polyps can prevent the development of colorectal cancer. However, it is fairly common-up to 20%-for polyps to be undetected in a colonoscopy due to poor visualization of the proximal aspect of colonic folds and anatomical flexures. To overcome these limitations, many new endoscopes and accessories have been developed. A wide-angle colonoscopy did not improve the detection of adenoma compared with the standard colonoscopy. An extra-wide angle and Retroview colonoscopies showed a significantly lower miss rate of polyps in the colon model...
December 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28012848/detection-of-sessile-serrated-adenomas-in-proximal-colon-using-wide-field-fluorescence-endoscopy
#14
Bishnu P Joshi, Zhenzhen Dai, Zhenghong Gao, Jeong Hoon Lee, Navin Ghimire, Jing Chen, Anoop Prabhu, Erik J Wamsteker, Richard S Kwon, Grace H Elta, Elena M Stoffel, Asha Pant, Tonya Kaltenbach, Roy M Soetikno, Henry D Appelman, Rork Kuick, D Kim Turgeon, Thomas D Wang
BACKGROUND & AIMS: Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigated whether this feature could be used with imaging methods to detect SSAs in patients. METHODS: We used phage display to identify a peptide that binds specifically to SSAs, using subtractive hybridization with HT29 colorectal cancer cells containing the V600E mutation in BRAF and Hs738...
December 21, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28011469/three-pathways-of-colonic-carcinogenesis-in-rats
#15
REVIEW
Carlos A Rubio
Colorectal cancer (CRC) is one of the more intensively studied human malignancies. For many years, the general view has been that the vast majority of CRCs in humans evolve from conventional (tubular or villous) adenomas via the adenoma-carcinoma pathway. More recently, serrated colorectal polyps (hyperplastic polyps, sessile serrated polyps and traditional serrated adenomas) have emerged as an alternative pathway of colorectal carcinogenesis in humans. Archival sections from early experiments in Sprague-Dawley (SD) rats injected with dimethylhydrazine (DMH) were reviewed and the histology of colonic neoplasias was re-evaluated...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28004603/asiatic-acid-attenuates-pre-neoplastic-lesions-oxidative-stress-biotransforming-enzymes-and-histopathological-alterations-in-1-2-dimethylhydrazine-induced-experimental-rat-colon-carcinogenesis
#16
Aktarul Islam Siddique, Vijay Mani, Sivaranjani Arivalagan, Nisha Susan Thomas, Namasivayam Nalini
Asiatic acid (AA), a pentacyclic triterpenoid derived from the tropical medicinal plant Centella asiatica is known to exhibit numerous pharmacological properties. We hypothesized that AA will have chemopreventive potential against 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis in male Wistar rats. Rats were arbitrarily divided into six groups. Group I rats were processed as control. Group II rats received AA (8 mg/kg b.w., p.o.) and groups III-VI rats received subcutaneous injections of DMH (20 mg/kg b...
December 22, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28004480/a-metagenomic-study-of-the-preventive-effect-of-lactobacillus-rhamnosus-gg-on-intestinal-polyp-formation-in-apc-min-mice
#17
Yueqiong Ni, Victoria Ho Yee Wong, William Chi Shing Tai, Jun Li, Wing Yan Wong, Magnolia Muk Lan Lee, Fiona Long Yan Fong, Hani El-Nezami, Gianni Panagiotou
AIMS: To investigate the in vivo effects of Lactobacillus rhamnosus GG (LGG) on intestinal polyp development and the interaction between this single-organism probiotic and the gut microbiota therein. METHODS AND RESULTS: The Apc(Min/+) mouse model was used to study the potential preventive effect of LGG on intestinal polyposis, while shotgun metagenomic sequencing was employed to characterize both taxonomic and functional changes within gut microbial community. We found that the progression of intestinal polyps in the control group altered the community functional profile remarkably despite small variation in the taxonomic diversity...
December 22, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28003719/cirrhotic-patients-have-worse-bowel-preparation-at-screening-colonoscopy-than-chronic-liver-disease-patients-without-cirrhosis
#18
Anika K Anam, Kunal Karia, Arun B Jesudian, Brian P Bosworth
BACKGROUND: Cirrhosis has been shown in small studies to be a predictor of suboptimal bowel preparation at screening colonoscopy. It has yet to be established whether patients with chronic liver disease in the absence of cirrhosis experience equally poor colon cleansing. Intestinal dysmotility related to cirrhosis might impair bowel preparation in this population more than those with chronic liver disease without cirrhosis. OBJECTIVE: This study compared the quality of bowel preparation in cirrhotic and non-cirrhotic patients with chronic liver disease and determined whether this influenced polyp detection rate...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28002874/high-serum-alanine-aminotransferase-is-associated-with-the-risk-of-colorectal-adenoma-in-korean-men
#19
Chang Mo Moon, Kyung Eun Yun, Seungho Ryu, Yoosoo Chang, Dong Il Park
BACKGROUND AND AIM: An elevated alanine aminotransferase (ALT) is frequently observed in subjects with metabolic syndrome, which is associated with the risk of colorectal adenoma (CRA). However, the relationship between ALT and CRA remains unclear. Therefore, we aimed to investigate whether high serum ALT is associated with the risk of CRA in a metabolically healthy population. METHODS: We conducted this cross-sectional study in 27,717 asymptomatic Korean adults who underwent a health checkup...
December 21, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27993873/adenomatous-colon-polyps-in-diabetes-increased-prevalence-in-patients-with-chronic-kidney-disease-and-its-association-with-parathyroid-hormone
#20
Deepshikha Nag Chowdhury, Youssef Botros, Vincent A DeBari, Walid Baddoura, Chandra B Chandran
Previous studies have shown a higher prevalence of malignancy in patients with diabetes mellitus (DM) and chronic kidney disease (CKD). The purpose of this study was to investigate the prevalence of adenomatous colon polyps (ACP) as they occur in subjects with DM and coexisting CKD. This is a retrospective cohort study of patients with DM (n=565) who had undergone colonoscopy between 2000-2010. The cohort was further bifurcated into those with CKD (n=296) and those with normal renal function (n=269). Presence or absence of ACP was measured in both groups...
December 2016: Annals of Clinical and Laboratory Science
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