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https://www.readbyqxmd.com/read/28430953/gastric-proteins-muc5ac-and-tff1-as-potential-diagnostic-markers-of-colonic-sessile-serrated-adenomas-polyps
#1
Magomed Khaidakov, Keith K Lai, D Roudachevski, Julietta Sargsyan, Hannah E Goyne, Rish K Pai, Laura W Lamps, Curt H Hagedorn
Objectives: A subset of colon cancers originates from sessile serrated adenomas/polyps (SSA/Ps). Our goal was to identify markers for SSA/Ps that could aid in distinguishing them from hyperplastic polyps (HPs). Methods: We performed immunostaining for gastric proteins MUC5AC and TFF1 in formalin-fixed, paraffin-embedded (FFPE) samples of HPs (n = 47), SSA/Ps (n = 37), and normal colon (n = 30). Results: Control mucosa expressed only trace amounts of MUC5AC and TFF1...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28429649/fundic-gland-polyps-in-the-pediatric-population
#2
Amy Coffey, Kalyani Patel, Norma Quintanilla, Richard Kellermayer, Hao Wu
We retrospectively studied the clinical and histologic features of pediatric fundic gland polyps (FGPs) in 16 patients. FGPs had an endoscopic prevalence of 0.25% in 8527 pediatric gastric biopsies. Five patients had familial adenomatous polyposis (FAP). The median age of onset was 17.7 years in FAP and 17.3 years in sporadic patients. All syndromic patients were asymptomatic and FGPs were identified during surveillance for existing or concurrent colon polyps. They did not take antacids. In comparison, all 11 sporadic FGPs were identified during evaluation of symptomatic patients who had taken antacids (median duration 21 months)...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28429597/is-capsule-colonoscopy-the-solution-for-incomplete-conventional-colonoscopy
#3
Miguel Mascarenhas-Saraiva
The era of colon capsule endoscopy (CCE) started in 2007. Few years later second-generation CCE (CCE-2) (Medtronic, Minneapolis, USA) was launched, featuring an improved optical system allowing for nearly 360° coverage via two 172° angle cameras, and adaptive frame rate function (ranging from 4 to 35 images per second depending on capsule motion). At present the main clinical indications for CCE are: a) completion of incomplete colonoscopy; b) polyp detection; and c) investigation of inflammatory bowel disease (IBD)...
April 21, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28428902/nonfamilial-juvenile-polyposis-syndrome-with-exon-5-novel-mutation-in-smad-4-gene
#4
Amna Ahmed, Badr Alsaleem
Juvenile polyposis syndrome (JPS) is a rare autosomal dominant hereditary disorder, characterized by multiple juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer. JPS is most frequently caused by mutations in the SMAD4 or BMPR1A genes. Herein, we report a child with juvenile polyposis syndrome (JPS) with a novel mutation in the SMAD4 gene. An 8-year-old boy presented with recurrent rectal bleeding and was found to have multiple polyps in the entire colon. The histology of the resected polyps was consistent with juvenile polyps...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28427387/serum-microrna-profile-in-patients-with-colon-adenomas-or-cancer
#5
Yajie Zhang, Min Li, Yijiang Ding, Zhimin Fan, Jinchun Zhang, Hongying Zhang, Bin Jiang, Yong Zhu
BACKGROUND: Colon cancer, one of the most common causes of cancer-related deaths, arises from adenomatous polyps. In these years, circulating microRNAs (miRNAs) have attracted increasing attention as novel biomarkers for colon cancers. The dysregulated circulating miRNAs in patients with colon adenomas has not been well-understood. METHODS: Here, we aimed to identify miRNA profile in the serum of patients with colon adenomas or colon cancer by using microarray. Then we validated eight differentially expressed miRNAs (DEMs) by qRT-PCR and predicted their targets...
April 20, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28424049/findings-in-young-adults-at-colonoscopy-from-a-hospital-service-database-audit
#6
Stephanie Wong, Ilmars Lidums, Christophe Rosty, Andrew Ruszkiewicz, Susan Parry, Aung Ko Win, Yoko Tomita, Sina Vatandoust, Amanda Townsend, Dainik Patel, Jennifer E Hardingham, David Roder, Eric Smith, Paul Drew, Julie Marker, Wendy Uylaki, Peter Hewett, Daniel L Worthley, Erin Symonds, Graeme P Young, Timothy J Price, Joanne P Young
BACKGROUND: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. METHODS: An audit of the colonoscopy database at The Queen Elizabeth Hospital in Adelaide, South Australia over a 12-month period was undertaken...
April 19, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28422327/association-between-the-ulcer-status-and-the-risk-of-delayed-bleeding-after-the-endoscopic-mucosal-resection-of-colon
#7
Gwang-Un Kim, Myeongsook Seo, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon
BACKGROUND AND AIM: Bleeding is the most common adverse event following colonoscopic endoscopic mucosal resection (EMR). We aimed to assess the clinical outcomes of a colon EMR according to the post-EMR ulcer status, and determine the risk factors of delayed postpolypectomy bleeding (DPPB) based on the post-EMR ulcer status. METHODS: We retrospectively reviewed the medical records and endoscopic images of patients who underwent EMR of colon polyps with diameters of ≥5 mm...
April 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28420165/impact-of-acetazolamide-a-carbonic-anhydrase-inhibitor-on-the-development-of-intestinal-polyps-in-min-mice
#8
Nobuharu Noma, Gen Fujii, Shingo Miyamoto, Masami Komiya, Ruri Nakanishi, Misato Shimura, Sei-Ichi Tanuma, Michihiro Mutoh
Colorectal cancer is a common cancer worldwide. Carbonic anhydrase (CA) catalyzes the reversible conversion of carbon dioxide to bicarbonate ion and a proton, and its inhibitor is reported to reduce cancer cell proliferation and induce apoptosis. Therefore, we asked whether acetazolamide, a CA inhibitor, could inhibit intestinal carcinogenesis. Five-week-old male Apc-mutant mice, Min mice, were fed a AIN-76A diet containing 200 or 400 ppm acetazolamide. As a result, acetazolamide treatment reduced the total number of intestinal polyps by up to 50% compared to the control group...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416054/-combined-endoscopic-laparoscopic-colon-polypectomy
#9
Sandra Jensen, Bo Rud
Combined endoscopic laparoscopic surgery (CELS) is a novel technique for resection of benign colon polyps, which are not amenable for endoscopic resection. A review of ten studies including 416 patients shows that polyps were successfully resected in 65-97% of the patients. Polyp recurrence after CELS is low, and the frequency of adenocarcinoma is comparable with the frequency in large polyps (> 2 cm) resected endoscopically. CELS can be performed for a variety of indications but should be done after renewed endoscopy...
April 10, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28414304/transforming-activity-and-therapeutic-targeting-of-c-terminal-binding-protein-2-in-apc-mutated-neoplasia
#10
E T Sumner, A T Chawla, A D Cororaton, J E Koblinski, R C Kovi, I M Love, B B Szomju, S Korwar, K C Ellis, S R Grossman
Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cells to anchorage independence similarly to mutant H-Ras. To investigate CtBP's contribution to in vivo tumorigenesis, Apc(min/+) mice, which succumb to massive intestinal polyposis, were bred to Ctbp2(+/-) mice...
April 17, 2017: Oncogene
https://www.readbyqxmd.com/read/28413499/identification-a-nonsense-mutation-of-apc-gene-in-chinese-patients-with-familial-adenomatous-polyposis
#11
Haishan Li, Lingling Zhang, Quan Jiang, Zhenwang Shi, Hanxing Tong
Familial adenomatous polyposis (FAP; Mendelian of Inherintance in Man ID, 175100) is a rare autosomal dominant disorder characterized by the development of numerous adenomatous polyps throughout the colon and rectum associated with an increased risk of colorectal cancer. FAP is at time accompanied with certain extraintestinal manifestations such as congenital hypertrophy of the retinal pigment epithelium, dental disorders and desmoid tumors. It is caused by mutations in the adenomatous polyposis coli (APC) gene...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28412271/impact-of-a-new-distal-attachment-on-colonoscopy-performance-in-an-academic-screening-center
#12
Zacharias P Tsiamoulos, Ravi Misra, Rajaratanam Rameshshanker, Timothy R Elliott, Iosif Beintaris, Siwan Thomas-Gibson, Adam Haycock, Noriko Suzuki, Colin Rees, Brian P Saunders
BACKGROUND AND AIMS: Distal attachments placed on the colonoscope tip may positively affect performance by assisting insertion and polyp detection. The Endocuff-original appears to improve adenoma detection rate, but there are no data assessing the performance of the second generation Endocuff-vision. METHODS: A pilot service evaluation study (April-2013/September-2014) was conducted on patients with positive faecal occult blood tests within the National Bowel Cancer Programme during 3 consecutive periods: pre-cuff/no device used, during-cuff/device used and post-cuff/no device used...
April 12, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28410235/cysteinyl-leukotriene-receptor-1-facilitates-tumorigenesis-in-a-mouse-model-of-colitis-associated-colon-cancer
#13
Janina Osman, Sayeh Savari, Naveen Kumar Chandrashekar, Kishan Bellamkonda, Desiree Douglas, Anita Sjölander
Cysteinyl leukotriene receptor 1 (CysLT1R) has been shown to be up-regulated in the adenocarcinomas of colorectal cancer patients, which is associated with a poor prognosis. In a spontaneous model of colon cancer, CysLT1R disruption was associated with a reduced tumor burden in double-mutant female mice (ApcMin/+/Cysltr1-/-) compared to ApcMin/+ littermates. In the current study, we utilized a genetic approach to investigate the effect of CysLT1R in the induced azoxymethane/dextran sulfate sodium (AOM/DSS) model of colitis-associated colon cancer...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408995/multiple-zonal-and-multi-zone-adenoma-detection-rates-according-to-quality-of-cleansing-during-colonoscopy
#14
Stefano Pontone, Cesare Hassan, Roberta Maselli, Paolo Pontone, Rita Angelini, Manuela Brighi, Gregorio Patrizi, Daniele Pironi, Fabio Massimo Magliocca, Angelo Filippini
BACKGROUND: The safety and diagnostic accuracy of colonoscopy depend on the quality of colon cleansing. The adenoma detection rate is usually used as a quality measurement score. OBJECTIVE: We aimed to introduce and evaluate three new parameters to determine polyps and adenomas segmental localization and their distribution in association with different bowel preparation levels during colonoscopy. We introduce the multiple adenoma detection rate (the percentage of patients with >2 adenomas diagnosed during colonoscopy), the zonal adenoma detection rate (the percentage of patients with >2 adenomas diagnosed during colonoscopy in different colon areas (rectum, sigmoid, descending, transverse, ascending and cecum colon)), and multi-zone adenoma detection rate (the percentage of patients with >2 adenomas diagnosed during colonoscopy in different colon areas with at least a segment between them with or without lesions (i...
December 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28408327/morbidity-and-mortality-after-surgery-for-nonmalignant-colorectal-polyps
#15
Anne F Peery, Nicholas J Shaheen, Katherine S Cools, Todd H Baron, Mark Koruda, Joseph A Galanko, Ian S Grimm
BACKGROUND & AIMS: Despite evidence that most non-malignant colorectal polyps can be managed endoscopically, a substantial proportion of patients with a non-malignant colorectal polyp are still sent to surgery. Risks associated with this surgery are not well characterized. We aimed to describe 30-day post-operative morbidity and mortality and to explore risk factors for adverse events in patients undergoing surgical resection for non-malignant colorectal polyps. METHODS: We analyzed data collected prospectively as part of the National Surgical Quality Improvement Program...
April 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28400194/increased-risk-of-colorectal-cancer-in-patients-with-multiple-serrated-polyps-and-their-first-degree-relatives
#16
Cecilia Egoavil, Miriam Juarez, Carla Guarinos, María Rodríguez-Soler, Eva Hernández-Illán, Cristina Alenda, Artemio Payá, Adela Castillejo, Anna Serradesanferm, Luis Bujanda, Fernando Fernández-Bañares, Joaquín Cubiella, Luisa de-Castro, Ana Guerra, Elena Aguirre, Alberto Herreros-de-Tejada, Xavier Bessa, Maite Herráiz, José-Carlos Marín-Gabriel, Judith Balmaña, Virginia Piñol, Miriam Cuatrecasas, Francesc Balaguer, Antoni Castells, José-Luis Soto, Pedro Zapater, Rodrigo Jover
BACKGROUND & AIMS: We investigated whether patients with multiple serrated polyps, but not meeting the World Health Organization criteria for serrated polyposis syndrome, and their relatives have similar risks for colorectal cancer (CRC) as those diagnosed with serrated polyposis. METHODS: We collected data from patients with more than 10 colonic polyps, recruited in 2008-2009 from 24 hospitals in Spain for a study of causes of multiple colonic polyps. We analyzed data from 53 patients who met the criteria for serrated polyposis and 145 patients who did not meet these criteria, but who had more than 10 polyps throughout the colon, of which more than 50% were serrated...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28398769/potential-involvement-of-the-epidermal-growth-factor-receptor-ligand-epiregulin-and-matrix-metalloproteinase-1-in-pathogenesis-of-chronic-rhinosinusitis
#17
Tetsuya Homma, Atsushi Kato, Masafumi Sakashita, Tetsuji Takabayashi, James E Norton, Lydia A Suh, Roderick G Carter, Kathleen E Harris, Anju T Peters, Leslie C Grammer, Jin-Young Min, Stephanie Shintani-Smith, Bruce K Tan, Kevin Welch, David B Conley, Robert C Kern, Robert P Schleimer
RATIONALE: Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease of the nose and paranasal sinuses that presents without (CRSsNP) or with nasal polyps (CRSwNP). Features of CRSwNP are the frequent presence of type 2 allergic inflammation and high prevalence of Staphylococcus aureus (SA) colonization. As inflammation persists, sinus tissue undergoes epithelial damage and repair along with polyp growth. Since one feature of damaged tissue is enhancement of growth factor signaling, we evaluated the presence of EGFR ligands and MMPs in CRS...
April 11, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28384603/raman-fiber-optical-method-for-colon-cancer-detection-cross-validation-and-outlier-identification-approach
#18
D Petersen, P Naveed, A Ragheb, D Niedieker, S F El-Mashtoly, T Brechmann, C Kötting, W H Schmiegel, E Freier, C Pox, K Gerwert
Endoscopy plays a major role in early recognition of cancer which is not externally accessible and therewith in increasing the survival rate. Raman spectroscopic fiber-optical approaches can help to decrease the impact on the patient, increase objectivity in tissue characterization, reduce expenses and provide a significant time advantage in endoscopy. In gastroenterology an early recognition of malign and precursor lesions is relevant. Instantaneous and precise differentiation between adenomas as precursor lesions for cancer and hyperplastic polyps on the one hand and between high and low-risk alterations on the other hand is important...
March 25, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28382323/the-impact-of-diet-liberalization-on-bowel-preparation-for-colonoscopy
#19
James Walter, Gloria Francis, Rebecca Matro, Ramalinga Kedika, Rachael Grosso, Scott W Keith, David Kastenberg
Background and study aims Dietary restrictions are integral to colonoscopy preparation and impact patient satisfaction. Utilizing split-dose, lower-volume polyethylene glycol 3350-electrolyte solution (PEG-ELS), this study compared colon preparation adequacy of a low-residue diet to clear liquids using a validated grading scale. Patients and methods This was a prospective, randomized, single-blinded, single-center non-inferiority study evaluating diet the day prior to outpatient colonoscopy. Subjects were randomized to a Low-Residue diet for breakfast and lunch, or Clears only...
April 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28381946/combined-endoscopic-laparoscopic-surgery-procedures-for-colorectal-surgery
#20
REVIEW
Sarah B Placek, Jeffrey Nelson
Colonoscopy is the standard of care for screening and surveillance of colorectal cancers. Removal of adenomatous polyps prevents the transformation of adenomas to potential adenocarcinoma. While most polyps are amenable to simple endoscopic polypectomy, difficult polyps that are large, broad-based, or located in haustral folds or in tortuous colon segments can present a challenge for endoscopists. Traditionally, patients with endoscopically unresectable polyps have been referred for oncologic surgical resection due to the underlying risk of malignancy within the polyp; however, the majority of these polyps are benign on final pathology...
April 2017: Clinics in Colon and Rectal Surgery
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