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https://www.readbyqxmd.com/read/29908363/video-based-assessments-of-colonoscopy-inspection-quality-correlate-with-quality-metrics-and-highlight-areas-for-improvement
#1
Anna Duloy, Rena H Yadlapati, Mark Benson, Andrew J Gawron, Charles J Kahi, Tonya R Kaltenbach, Jessica McClure, Dyanna L Gregory, Rajesh N Keswani
BACKGROUND & AIMS: Adenoma detection rate (ADR) and serrated polyp detection rate (SDR) vary significantly among colonoscopists. Colonoscopy inspection quality (CIQ) is the quality with which a colonoscopist inspects for polyps and may explain some of this variation. We aimed to determine the relationship between CIQ and historical ADRs and SDRs in a cohort of colonoscopists and assess whether there is variation in CIQ components (fold examination, cleaning, and luminal distension) among colonoscopists with similar ADRs and SDRs...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29901124/a-novel-apc-mutation-identified-in-a-large-chinese-family-with-familial-adenomatous-polyposis-and-a-brief-literature-review
#2
Minghui Pang, Yijun Liu, Xiaolin Hou, Jialiang Yang, Xuelai He, Nengyi Hou, Peixi Liu, Luo Liang, Junwen Fu, Kang Wang, Zimeng Ye, Bo Gong
Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible for the majority of cases of FAP. The purpose of the present study was to report the clinical features of a Chinese family with FAP and screen for novel mutations using the targeted next‑generation sequencing technology. Among the 29 family members, 12 were diagnosed of FAP...
June 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29898664/an-unusual-diverticulum-adjacent-to-two-large-colonic-polyps-a-case-report
#3
John Schembri, Jonathan Bury, Lesley Hunt, Stuart Riley
BACKGROUND: Adenocarcinomas can arise in a variety of circumstances in which intestinal segments have been used for urinary diversions. Whereas ureterosigmoidostomy is the oldest and simplest form of continent urinary diversion it also seems to be the most dangerous in this regard. Herein we present a case of colonic neoplasia complicating a non-functioning ureterosigmoidostomy after 55 years; the longest latent period documented to date. CASE PRESENTATION: A 56-year-old lady born with congenital bladder exystrophy and who had a functional ileal conduit presented to us with a 6 month history of change in bowel habit and rectal bleeding...
June 14, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29885783/acute-lower-gastrointestinal-bleeding-in-sudanese-patients-a-study-on-301-patients-in-a-specialized-centre
#4
Nassir Alhaboob Arabi, Abdulmagid Mohammed Musaad, Fatima Abbas Habiballah Mohammed, Elsaggad Eltayeb Ahmed, Muataz Salah Eldin Abdelaziz
BACKGROUND AND STUDY AIMS: Lower gastrointestinal bleeding originates from a site distal to the ligament of Treitz. It can present as an acute life-threatening or chronicbleeding. It is common among older patients and those with comorbidity. The common causes are diverticular disease, angiodysplasias, neoplasms, colitis, ischaemia and anorectal disorders. The aim of this study is to determine the prevalence and causes of acute lower gastrointestinal bleeding among Sudanese patients. PATIENTS AND METHODS: In a period of 2 years we studied 301 patients with fresh rectal bleeding out of 5625 patients with gastrointestinal bleeding in Ibn Sina Specialized Hospital, Khartoum, Sudan, This is a cross sectional observational hospital based study...
June 6, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29881619/risk-stratification-of-colorectal-polyps-for-predicting-residual-or-recurring-adenoma-using-the-size-morphology-site-access-score
#5
Rita Barosa, Noor Mohammed, Bjorn Rembacken
Background and Aims: Endoscopic mucosal resection is an effective and safe procedure to manage large non-pedunculated colonic polyps for which residual/recurrent adenoma is the main drawback. Size/Morphology/Site/Access score determines polypectomy difficulty. We aimed to describe residual/recurrent adenoma rate according to Size/Morphology/Site/Access and to select the ize/Morphology/Site/Access cut-off to predict low residual/recurrent adenoma. Methods: This was a retrospective cohort study of endoscopic mucosal resection for large non-pedunculated colonic polyps performed in a tertiary centre...
May 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29876742/helicobacter-pylori-is-associated-with-increased-risk-of-serrated-colonic-polyps-analysis-of-serrated-polyp-risk-factors
#6
Anand Kumar, Mimi Kim, Dana J Lukin
BACKGROUND: Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) are recognized precursors of colorectal cancer, but their risk factors are not well established. We investigated the association between Helicobacter pylori infection (HPI) and the development of SSA and TSA. METHODS: Retrospective data were collected on patients aged ≥ 18 years that underwent colonoscopy with biopsy between 2006 and 2016. Based on histology, patients were classified into three groups: those with SSA and/or TSA, (serrated neoplasia group, SN); conventional adenomas only (CA); and with no polyps (NP)...
June 7, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29876047/laparoscopic-management-of-snare-entrapment-during-colonoscopic-polypectomy
#7
Rachel E Martin, Mark K Soliman
Colonoscopic polypectomy reduces the risk of colon cancer development by interrupting the adenoma to carcinoma progression. A variety of techniques are available to perform polypectomy including the use of forceps or snare device with or without electrocautery. While forceps polypectomy tends to be the procedure of choice for small polyps, snare polypectomy has been found to be the preferred method for removal of polyps 1 cm or greater in size. The two most common post-polypectomy complications are bleeding and perforation...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29875879/characteristic-profiles-of-dna-epigenetic-modifications-in-colon-cancer-and-its-predisposing-conditions-benign-adenomas-and-inflammatory-bowel-disease
#8
Tomasz Dziaman, Daniel Gackowski, Jolanta Guz, Kinga Linowiecka, Magdalena Bodnar, Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Anna Szpila, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski, Andrzej Marszalek, Ryszard Olinski
Background: Active demethylation of 5-methyl-2'-deoxycytidine (5-mdC) in DNA occurs by oxidation to 5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC) and further oxidation to 5-formyl-2'-deoxycytidine (5-fdC) and 5-carboxy-2'-deoxycytidine (5-cadC), and is carried out by enzymes of the ten-eleven translocation family (TETs 1, 2, 3). Decreased level of epigenetic DNA modifications in cancer tissue may be a consequence of reduced activity/expression of TET proteins. To determine the role of epigenetic DNA modifications in colon cancer development, we analyzed their levels in normal colon and various colonic pathologies...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29869371/colon-capsule-endoscopy-for-inflammatory-bowel-disease
#9
REVIEW
Jiao Li, Wai K Leung
Colon capsule endoscopy (CCE) is designed for direct visualization of the colonic mucosa through passive propulsion. The role of CCE on detection of colonic polyps has been extensively evaluated. As mucosal healing has emerged as a pivotal target for treatment of inflammatory bowel disease (IBD), there is increasing data to suggest that CCE can also be used in the monitoring of mucosal inflammation in patients with active IBD, particularly in ulcerative colitis (UC) and also in Crohn's disease (CD). Despite advantages such as its non-invasive nature, patient's comfort, safety, and access to anatomical regions not easily reached by conventional endoscopy, CE has limitations including the lack of ability to obtain biopsies or therapeutic capabilities and no control over movement...
June 4, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29867933/dysbiosis-associated-polyposis-of-the-colon-cap-polyposis
#10
Kazuki Okamoto, Tomohiro Watanabe, Yoriaki Komeda, Ayana Okamoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Toshiharu Sakurai, Tomonori Tanaka, Hiroki Sakamoto, Kiyoshige Fujimoto, Naoshi Nishida, Masatoshi Kudo
Cap polyposis is a rare gastrointestinal disease characterized by multiple inflammatory polyps located between the distal colon and the rectum. Despite the lack of clarity regarding its pathogenesis, mucosal prolapse, chronic inflammatory responses, and Helicobacter pylori infection are considered key contributors to the development of this disease entity. Although it is now generally accepted that dysbiosis of gut microbiota is associated with intestinal and extra-intestinal diseases, alterations of intestinal microbiota have been poorly defined in cap polyposis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29864420/natural-history-of-colonic-polyposis-in-young-patients-with-familial-adenomatous-polyposis
#11
Shashank Sarvepalli, Carol A Burke, Marc Monachese, Brandie H Leach, Lisa Laguardia, Margaret O'Malley, Matthew F Kalady, James M Church
BACKGROUND AND AIMS: Proctocolectomy prevents colorectal cancer in familial adenomatous polyposis (FAP). Colorectal polyp progression is one of the indications for surgery. No data exist regarding the natural history of colorectal polyposis in young patients with FAP. This study examined the rate of polyposis progression and factors associated with it. METHODS: FAP patients <30 years old and with ≥2 colonoscopies with the first colonoscopy after year 2000 were identified...
June 1, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29848681/mycophenolate-mofetil-alone-and-in-combination-with-tacrolimus-inhibits-the-proliferation-of-ht-29-human-colonic-adenocarcinoma-cell-line-and-might-interfere-with-colonic-tumorigenesis
#12
Galina Ling, Sergio Lamprecht, George Shubinsky, Lidia Osyntsov, Baruch Yerushalmi, Ilya Pinsk, Vered Pinsk, Eduard Ling
BACKGROUND/AIM: Familial adenomatous polyposis (FAP) was found to be completely reversed in a patient treated with mycophenolate mofetil (MMF) and tacrolimus following kidney transplantation. In this preliminary study, we assessed whether MMF and tacrolimus alone or in combination interfere with the cell cycle and proliferation in a human colonic adenocarcinoma cell line and in the colonic polyps of the patient with FAP. MATERIALS AND METHODS: Human colonic adenocarcinoma HT-29 cells were treated with tacrolimus and MMF alone and in combination at different concentrations...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29846845/associations-of-dietary-fat-with-risk-of-early-neoplasia-in-the-proximal-colon-in-a-population-based-case-control-study
#13
Allen Mo, Rong Wu, James P Grady, Matthew P Hanley, Margaret Toro, Helen Swede, Thomas J Devers, Terryl J Hartman, Daniel W Rosenberg
PURPOSE: Excess dietary fat consumption is strongly associated with the risk of colorectal cancer, but less is known about its role in the earliest stages of carcinogenesis, particularly within the proximal colon. In the following case-control study, we evaluated the relationship between the intake of dietary fats and the frequency of early proximal neoplasia [aberrant crypt foci (ACF) or polyps], detectable by high-definition colonoscopy with contrast dye-spray. METHODS: Average-risk screening individuals underwent a high-definition colonoscopy procedure as part of larger ongoing clinical study of precancerous lesions in the proximal colon...
May 30, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29844950/living-upside-down-patterns-of-red-coral-settlement-in-a-cave
#14
Federica Costantini, Luca Rugiu, Carlo Cerrano, Marco Abbiati
Background: Larval settlement and intra-specific interactions during the recruitment phase are crucial in determining the distribution and density of sessile marine populations. Marine caves are confined and stable habitats. As such, they provide a natural laboratory to study the settlement and recruitment processes in sessile invertebrates, including the valuable Mediterranean red coral Corallium rubrum . In the present study, the spatial and temporal variability of red coral settlers in an underwater cave was investigated by demographic and genetic approaches...
2018: PeerJ
https://www.readbyqxmd.com/read/29807391/dielectric-properties-of-colon-polyps-cancer-and-normal-mucosa-ex-vivo-measurements-from-0-5-to-20-ghz
#15
Marta Guardiola, Santiago Buitrago, Glòria Fernández-Esparrach, Joan M O'Callaghan, Jordi Romeu, Miriam Cuatrecasas, Henry Córdova, Miguel Ángel González Ballester, Oscar Camara
PURPOSE: Colorectal cancer is highly preventable by detecting and removing polyps, which are the precursors. Currently, the most accurate test is colonoscopy, but still misses 22% of polyps due to visualization limitations. In this paper we preliminary assess the potential of microwave imaging and dielectric properties (e.g. complex permittivity) as a complementary method for detecting polyps and cancer tissue in the colon. The dielectric properties of biological tissues have been used in a wide variety of applications, including safety assessment of wireless technologies and design of medical diagnostic or therapeutic techniques (microwave imaging, hyperthermia and ablation)...
May 28, 2018: Medical Physics
https://www.readbyqxmd.com/read/29805353/cronkhite-canada-syndrome-associated-with-metastatic-colon-cancer
#16
Shirin Haghighi, Sima Noorali, Amir Houshang Mohammad Alizadeh
Cronkhite-Canada syndrome is characterized by gastrointestinal and ectodermal manifestations. In this paper, we describe a 64-year-old Iranian male, presenting with Cronkhite-Canada syndrome with metastatic colon cancer. The patient was suffering from hair loss, which occurred on the scalp at first and then, during 5 months, extended to the whole body. After that, his sense of taste was impaired, and 2 months later, gastrointestinal symptoms gradually started, with weight loss of 20 kg over 2 months with an initial weight of 100 kg...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29804199/identification-of-a-novel-grem1-duplication-in-a-patient-with-multiple-colon-polyps
#17
Danielle B McKenna, Jeroen Van Den Akker, Alicia Y Zhou, Lauren Ryan, Annette Leon, Robert O'Connor, Payal D Shah, Anil K Rustgi, Bryson W Katona
Hereditary mixed polyposis syndrome (HMPS) is a hereditary syndrome that is characterized by multiple colon polyps of mixed pathologic subtypes and an increased risk for colorectal cancer. A 40 kb duplication in the 5' regulatory region of the GREM1 gene was recently found to be the causal mutation in a subset of Ashkenazi Jewish families with HMPS. Given this discovery, the GREM1 5' regulatory region is now analyzed on many different multi-gene cancer panels, however the data on duplications distinct from the 40 kb duplication remains minimal...
May 26, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29791426/-familiar-adenomatous-polyposis-report-of-2-cases
#18
Luis Vásquez Elera, Patricia Guzman Rojas, Manuel Sánchez Herrera, Víctor Prado, Carlos García Encinas, Eduar Albán Bravo Paredes, Alejandro Bussalleu
Familial Adenomatous polyposis (FAP) it is based on an autosomal dominant mutation which results in loss of function of theAPC tumor suppressor gene. On the other hand, Gardner syndrome is a type of FAP and is characterized for multiple colonic adenomatous polyps and extracolonic abnormalities as desmoid tumors, osteomas, lipomas, dental abnormalities, dermoid cysts and duodenal adenomas. This report aims to present two patients with FAP: The first one is a patient who presented with osteomas and hematochezia, being diagnosed with Gardner Syndrome after the colonoscopy...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29789649/superficially-serrated-adenoma-a-proposal-for-a-novel-subtype-of-colorectal-serrated-lesion
#19
Taiki Hashimoto, Yusaku Tanaka, Reiko Ogawa, Taisuke Mori, Hiroshi Yoshida, Hirokazu Taniguchi, Nobuyoshi Hiraoka, Motohiro Kojima, Yasuhiro Oono, Yutaka Saito, Shigeki Sekine
We describe a series of colorectal polyps characterized by mixed adenomatous and serrated features, herein referred to as superficially serrated adenomas. Twenty superficially serrated adenomas were obtained from 11 female and 9 male patients aged 62-87 years. Most lesions endoscopically appeared as small sessile polyps, but larger lesions were plaque-like (2-20 mm; median, 5 mm). Eighteen lesions (90%) were located in the sigmoid colon or rectum. They consisted primarily of straight, adenomatous glands but showed serration confined to the superficial layer...
May 22, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29785566/delineating-a-new-feature-of-constitutional-mismatch-repair-deficiency-cmmrd-syndrome-breast-cancer
#20
Lisa Bush, Melyssa Aronson, Uri Tabori, Brittany B Campbell, Raymond B Bedgood, Kory Jasperson
Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare autosomal recessive hereditary cancer condition, characterized by an exceptionally high risk of cancer, a propensity for childhood malignancies, and cutaneous features reminiscent of neurofibromatosis type 1 (NF1). We report on two sisters originally suspected of having CMMRD syndrome due to their history of colonic polyps and NF1 associated skin findings, both were subsequently found to have biallelic MSH6 mutations. After years of CMMRD syndrome follow-up, the proband was diagnosed with breast cancer at age 29, while her sister was diagnosed with a glioblastoma at age 27...
May 21, 2018: Familial Cancer
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