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Fatemeh Sedaghat, Matin Ghanavati, Parisa Nezhad Hajian, Sara Hajishirazi, Mehdi Ehteshami, Bahram Rashidkhani
AIM: To assess the relation between nutrient patterns and cataract risk. METHODS: This is a hospital-based case-control study with 97 cataract patients and 198 matched controls. Dietary consumption was collected through a valid food frequency questionnaire (FFQ). Nutrient patterns were detected by applying factor analysis. Unconditional logistic regression models were used to estimate odds ratio (ORs) and 95%CIs. RESULTS: We extracted 5 main nutrient patterns...
2017: International Journal of Ophthalmology
Apinya Wisutiamonkul, Charles Ampomah-Dwamena, Andrew C Allan, Saichol Ketsa
Carotenoid content in durian (Durio zibethinus) fruit is an important aspect of fruit quality, with different cultivars distinguished by differing pigmentation. We have studied the dependence of carotenogenesis on ethylene. Fruit of the cultivar 'Chanee' harvested at the mature stage were either left untreated (controls), treated with 1-methylcyclopropene (1-MCP) for 12 h, or treated with application of an aqueous ethephon solution to the stem end, or treated for 12 h with 1-MCP followed by ethephon application...
June 2017: Plant Physiology and Biochemistry: PPB
J Libien, M J Kupersmith, W Blaner, M P McDermott, S Gao, Y Liu, J Corbett, M Wall
INTRODUCTION: Vitamin A and its metabolites (called retinoids) have been thought to play a role in the development of idiopathic intracranial hypertension (IIH). The IIH Treatment Trial (IIHTT) showed the efficacy of acetazolamide (ACZ) in improving visual field function, papilledema grade, quality of life and cerebrospinal fluid (CSF) pressure. We postulated that IIH patients would demonstrate elevated measures of vitamin A metabolites in the serum and CSF. METHODS: Comprehensive measures of serum vitamin A and its metabolites were obtained from 96 IIHTT subjects, randomly assigned to treatment with ACZ or placebo, and 25 controls with similar gender, age and body mass index (BMI)...
January 15, 2017: Journal of the Neurological Sciences
Feifei Chen, Jiyi Hu, Ping Liu, Jing Li, Zheng Wei, Peng Liu
Carotenoids may play a protective role in the development of non-Hodgkin lymphoma (NHL), but findings from epidemiological studies on the associations between carotenoid intake and NHL risk are inconsistent. We therefore performed a meta-analysis to systemically evaluate the associations. Eligible studies were identified by a search of PubMed, Web of Science, Embase, and article reference lists. We pooled risk estimates from individual studies using a random-effect model to quantify the associations between intakes of specific carotenoids and NHL risk...
June 2017: Annals of Hematology
Christopher R D'Adamo, Valerie J Dawson, Kathleen A Ryan, Laura M Yerges-Armstrong, Richard D Semba, Nanette I Steinle, Braxton D Mitchell, Alan R Shuldiner, Patrick F McArdle
BACKGROUND/AIMS: Alpha-carotene is a provitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. Previous studies have suggested that genetic variants influence serum concentrations of provitamin A carotenoids, but to date no variants have been robustly associated with serum α-carotene concentrations. The aim of this study was to identify genetic associations with serum α-carotene concentrations using the genome-wide association study (GWAS) approach...
2016: Journal of Nutrigenetics and Nutrigenomics
Ahmad H Daraghmeh, Monica L Bertoia, Mazen O Al-Qadi, Abdulrahman M Abdulbaki, Mary B Roberts, Charles B Eaton
BACKGROUND AND AIMS: Emerging evidence suggests that low levels of vitamin D may be an important risk factor for multiple chronic diseases and mortality, but the evidence is mixed. Vitamin D levels are associated with sun exposure, diet, and metabolic status. One potential explanation for the lack of consistent findings amongst various studies is that low vitamin levels may be associated with poor diets or other risk factors that we were not adequately controlled for in different analyses...
December 2016: Atherosclerosis
Raúl Baena Ruiz, Pedro Salinas Hernández
BACKGROUND: In recent years, natural compounds called "phytochemicals", which are present in fruits, vegetables, and plants, have received special attention due to their potential to interfere with tumour formation and development. Many of these phytochemicals are being used in chemoprevention strategies. However, the scientific evidence regarding the modification of cancer risk continues to be debated. OBJECTIVE: The aim of this paper is to review the current scientific evidence and the most relevant epidemiological studies regarding the consumption or use of phytochemicals and their effects on the incidence of cancer...
December 2016: Maturitas
Mengjin Cao, Xuesong Zhang, Xiaojiig Wang, Xiang Shen, Zhu Wang
OBJECTIVE: To optimize the determination method of carotene in order to separate the alpha and beta carotene. METHODS: The homogenized samples were extracted with ethanol before saponification, and then extracted with petroleum ether followed by wash, dry and concentration. At last, the separation was performed on the high performance liquid chromatographic with YMC Carotenoid C30 column (3 microm 4.6 mm x 150 mm). The mobile phase was consisted of A (methanol: acetonitrile: water = 73...
May 2016: Wei Sheng Yan Jiu, Journal of Hygiene Research
Kristine Pezdirc, Melinda J Hutchesson, Rebecca L Williams, Megan E Rollo, Tracy L Burrows, Lisa G Wood, Christopher Oldmeadow, Clare E Collins
BACKGROUND: Consumption of dietary carotenoids from fruits and vegetables (F/V) leads to accumulations in human skin, altering skin yellowness. The influence of the quantity of F/V consumed on skin yellowness and plasma carotenoid concentrations has not been examined previously. OBJECTIVE: To compare the influence of consuming high-carotenoid-containing F/V (HCFV) (176,425 μg beta carotene/wk) vs low-carotenoid F/V (LCFV) (2,073 μg beta carotene/wk) on skin yellowness and plasma carotenoid concentrations, over 4 weeks...
August 2016: Journal of the Academy of Nutrition and Dietetics
Kyoung-Bok Min, Jin-Young Min
PURPOSE: Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with telomere length is less certain. We investigated the association between blood carotenoid levels and leukocyte telomere length in a representative sample of US adults. METHODS: We analyzed 3660 participants aged 20 years and older in the 1999-2002 National Health and Nutrition Examination Survey...
April 2017: European Journal of Nutrition
Michael I McBurney, Elaine A Yu, Eric D Ciappio, Julia K Bird, Manfred Eggersdorfer, Saurabh Mehta
Vitamin E is an essential nutrient for human health, with an established function as a lipid-soluble antioxidant that protects cell membranes from free radical damage. Low vitamin E status has been linked to multiple health outcomes, including total mortality. With vitamin E being identified as a 'shortfall nutrient' because >90% of American adults are not consuming recommended amounts of vitamin E, we aimed to determine the prevalence of both clinical vitamin E deficiency (serum α-tocopherol concentration < 12 μmol/L) and failure to meet a criterion of vitamin E adequacy, serum α-tocopherol concentration of 30 μmol/L, based on the Estimated Average Requirement (EAR) and lowest mortality rate in the Alpha-Tocopherol Beta-Carotene (ATBC) study...
2015: PloS One
Catherine Feart, Luc Letenneur, Catherine Helmer, Cécilia Samieri, Wolfgang Schalch, Stéphane Etheve, Cécile Delcourt, Jean-François Dartigues, Pascale Barberger-Gateau
BACKGROUND: Although intake of fruits and vegetables has been associated with a decreased risk of dementia, studies focusing on nutrients underlying this association are lacking. Our objective was to analyze the relation between plasma carotenoids and the risk of dementia and Alzheimer's disease (AD) in French elderly community dwellers. METHODS: The study population consisted of 1,092 nondemented older participants, from the Three-City-Bordeaux cohort followed for up to 10 years (range: 1...
May 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Salman Azeem, Syed Wasif Gillani, Ammar Siddiqui, Suresh Babu Jandrajupalli, Vinci Poh, Syed Azhar Syed Sulaiman
Diet is one of the major factors that can exert a majorly influence on colorectal cancer risk. This systematic review aimed to find correlations between various diet types, food or nutrients and colorectal cancer risk among Asian populations. Search limitations included Asian populations residing in Asia, being published from the year 2008 till present, and written in the English language. A total of 16 articles were included in this systematic review. We found that red meats, processed meats, preserved foods, saturated/animal fats, cholesterol, high sugar foods, spicy foods, tubers or refined carbohydrates have been found by most studies to have a positive association with colorectal cancer risk...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Rachael Z Stolzenberg-Solomon, Christina C Newton, Debra T Silverman, Michael Pollak, Leticia M Nogueira, Stephanie J Weinstein, Demetrius Albanes, Satu Männistö, Eric J Jacobs
Adiposity is associated with pancreatic cancer; however, the underlying mechanism(s) is uncertain. Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher concentrations. We conducted a pooled, nested case-control study of cohort participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and the Cancer Prevention Study II Nutrition Cohort to investigate whether prediagnostic serum leptin was associated with pancreatic cancer...
August 1, 2015: American Journal of Epidemiology
Alison M Mondul, Steven C Moore, Stephanie J Weinstein, Edward D Karoly, Joshua N Sampson, Demetrius Albanes
Despite decades of concerted epidemiological research, relatively little is known about the etiology of prostate cancer. As genome-wide association studies have identified numerous genetic variants, so metabolomic profiling of blood and other tissues represents an agnostic, "broad-spectrum" approach for examining potential metabolic biomarkers of prostate cancer risk. To this end, we conducted a prospective analysis of prostate cancer within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort based on 200 cases (100 aggressive) and 200 controls (age- and blood collection date-matched) with fasting serum collected up to 20 years prior to case diagnoses...
November 1, 2015: International Journal of Cancer. Journal International du Cancer
Rupjyoti Talukdar, H V V Murthy, D Nageshwar Reddy
BACKGROUND: Pain in CP results from inflammation and neuroimmune alterations that are associated with oxidative stress, among other mechanisms. This is marked by depletion of antioxidant defenses including methionine, which is a donor of methyl moieties that maintains the acinar transsulfuration pathway. We performed a systematic review and meta-analysis of trials evaluating methionine-containing antioxidants in CP. PATIENT AND METHODS: Literature search was conducted in Medline/Pubmed, EMBASE, and Cochrane databases...
March 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Felipe R Bruniera, Felipe M Ferreira, Luiz R M Savioli, Marcelo R Bacci, David Feder, Edimar C Pereira, Mavilde L G Pedreira, Maria A S Peterlini, Fábio F Perazzo, Ligia A Azzalis, Paulo C P Rosa, Virginia B C Junqueira, Monica A Sato, Fernando L A Fonseca
Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it is not considered a first-choice drug because of its adverse effects. It is believed that oxidative stress is the primary mechanism of endothelial injury and the consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates and types of infusion are still controversial. The aim of this study was to determine the effect of different VCM dilutions in endothelial, liver and kidney injuries by biochemical parameters and histopathological analysis...
December 2014: Anais da Academia Brasileira de Ciências
Alessio Alesci, Andrea Salvo, Eugenia Rita Lauriano, Teresa Gervasi, Deborah Palombieri, Maurizio Bruno, Simona Pergolizzi, Nicola Cicero
The effect of astaxanthin (3,3'-dihydroxy-s-carotene-4,4'-dione) on alcohol-induced morphological changes in Carassius auratus, as an experimental model, was determined. The yeast Phaffia rhodozyma was used as a source of astaxanthin. The animals were divided into three groups for 30 days: one group was treated with ethanol at a dose of 1.5% mixed in water, the second one with EtOH 1.5% and food enriched with astaxanthin from P. rhodozyma, and the third was a control group. After a sufficient experimental period, the samples were processed using light microscopy and evaluated by histomorphological and histochemical staining, and the data were supported by immunohistochemical analysis, using a wide range of antibodies, such as calbindin, vimentin and alpha-smooth muscle actin...
2015: Natural Product Research
Gabriella M Anic, Stephanie J Weinstein, Alison M Mondul, Satu Männistö, Demetrius Albanes
OBJECTIVES: Vitamin D may prolong cancer survival by inhibiting tumor progression and metastasis, however, there are limited epidemiologic studies regarding the association between circulating 25-hydroxyvitamin D (25(OH)D) and lung cancer survival. The aim of this study was to examine the relationship between serum 25(OH)D and lung cancer specific survival and to evaluate whether vitamin D binding protein (DBP) concentration modified this association. MATERIALS AND METHODS: 25(OH)D and DBP were measured in fasting serum samples from 500 male lung cancer cases in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study...
December 2014: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Saeed R Khan
Calcium oxalate (CaOx) kidney stones are formed attached to Randall's plaques (RPs) or Randall's plugs. Mechanisms involved in the formation and growth are poorly understood. It is our hypothesis that stone formation is a form of pathological biomineralization or ectopic calcification. Pathological calcification and plaque formation in the body is triggered by reactive oxygen species (ROS) and the development of oxidative stress (OS). This review explores clinical and experimental data in support of ROS involvement in the formation of CaOx kidney stones...
September 1, 2014: Translational Andrology and Urology
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