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Mengjin Cao, Xuesong Zhang, Xiaojiig Wang, Xiang Shen, Zhu Wang
OBJECTIVE: To optimize the determination method of carotene in order to separate the alpha and beta carotene. METHODS: The homogenized samples were extracted with ethanol before saponification, and then extracted with petroleum ether followed by wash, dry and concentration. At last, the separation was performed on the high performance liquid chromatographic with YMC Carotenoid C30 column (3 microm 4.6 mm x 150 mm). The mobile phase was consisted of A (methanol: acetonitrile: water = 73...
May 2016: Wei Sheng Yan Jiu, Journal of Hygiene Research
Kristine Pezdirc, Melinda J Hutchesson, Rebecca L Williams, Megan E Rollo, Tracy L Burrows, Lisa G Wood, Christopher Oldmeadow, Clare E Collins
BACKGROUND: Consumption of dietary carotenoids from fruits and vegetables (F/V) leads to accumulations in human skin, altering skin yellowness. The influence of the quantity of F/V consumed on skin yellowness and plasma carotenoid concentrations has not been examined previously. OBJECTIVE: To compare the influence of consuming high-carotenoid-containing F/V (HCFV) (176,425 μg beta carotene/wk) vs low-carotenoid F/V (LCFV) (2,073 μg beta carotene/wk) on skin yellowness and plasma carotenoid concentrations, over 4 weeks...
August 2016: Journal of the Academy of Nutrition and Dietetics
Kyoung-Bok Min, Jin-Young Min
PURPOSE: Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with telomere length is less certain. We investigated the association between blood carotenoid levels and leukocyte telomere length in a representative sample of US adults. METHODS: We analyzed 3660 participants aged 20 years and older in the 1999-2002 National Health and Nutrition Examination Survey...
January 27, 2016: European Journal of Nutrition
Michael I McBurney, Elaine A Yu, Eric D Ciappio, Julia K Bird, Manfred Eggersdorfer, Saurabh Mehta
Vitamin E is an essential nutrient for human health, with an established function as a lipid-soluble antioxidant that protects cell membranes from free radical damage. Low vitamin E status has been linked to multiple health outcomes, including total mortality. With vitamin E being identified as a 'shortfall nutrient' because >90% of American adults are not consuming recommended amounts of vitamin E, we aimed to determine the prevalence of both clinical vitamin E deficiency (serum α-tocopherol concentration < 12 μmol/L) and failure to meet a criterion of vitamin E adequacy, serum α-tocopherol concentration of 30 μmol/L, based on the Estimated Average Requirement (EAR) and lowest mortality rate in the Alpha-Tocopherol Beta-Carotene (ATBC) study...
2015: PloS One
Catherine Feart, Luc Letenneur, Catherine Helmer, Cécilia Samieri, Wolfgang Schalch, Stéphane Etheve, Cécile Delcourt, Jean-François Dartigues, Pascale Barberger-Gateau
BACKGROUND: Although intake of fruits and vegetables has been associated with a decreased risk of dementia, studies focusing on nutrients underlying this association are lacking. Our objective was to analyze the relation between plasma carotenoids and the risk of dementia and Alzheimer's disease (AD) in French elderly community dwellers. METHODS: The study population consisted of 1,092 nondemented older participants, from the Three-City-Bordeaux cohort followed for up to 10 years (range: 1...
May 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Salman Azeem, Syed Wasif Gillani, Ammar Siddiqui, Suresh Babu Jandrajupalli, Vinci Poh, Syed Azhar Syed Sulaiman
Diet is one of the major factors that can exert a majorly influence on colorectal cancer risk. This systematic review aimed to find correlations between various diet types, food or nutrients and colorectal cancer risk among Asian populations. Search limitations included Asian populations residing in Asia, being published from the year 2008 till present, and written in the English language. A total of 16 articles were included in this systematic review. We found that red meats, processed meats, preserved foods, saturated/animal fats, cholesterol, high sugar foods, spicy foods, tubers or refined carbohydrates have been found by most studies to have a positive association with colorectal cancer risk...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Rachael Z Stolzenberg-Solomon, Christina C Newton, Debra T Silverman, Michael Pollak, Leticia M Nogueira, Stephanie J Weinstein, Demetrius Albanes, Satu Männistö, Eric J Jacobs
Adiposity is associated with pancreatic cancer; however, the underlying mechanism(s) is uncertain. Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher concentrations. We conducted a pooled, nested case-control study of cohort participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and the Cancer Prevention Study II Nutrition Cohort to investigate whether prediagnostic serum leptin was associated with pancreatic cancer...
August 1, 2015: American Journal of Epidemiology
Alison M Mondul, Steven C Moore, Stephanie J Weinstein, Edward D Karoly, Joshua N Sampson, Demetrius Albanes
Despite decades of concerted epidemiological research, relatively little is known about the etiology of prostate cancer. As genome-wide association studies have identified numerous genetic variants, so metabolomic profiling of blood and other tissues represents an agnostic, "broad-spectrum" approach for examining potential metabolic biomarkers of prostate cancer risk. To this end, we conducted a prospective analysis of prostate cancer within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort based on 200 cases (100 aggressive) and 200 controls (age- and blood collection date-matched) with fasting serum collected up to 20 years prior to case diagnoses...
November 1, 2015: International Journal of Cancer. Journal International du Cancer
Rupjyoti Talukdar, H V V Murthy, D Nageshwar Reddy
BACKGROUND: Pain in CP results from inflammation and neuroimmune alterations that are associated with oxidative stress, among other mechanisms. This is marked by depletion of antioxidant defenses including methionine, which is a donor of methyl moieties that maintains the acinar transsulfuration pathway. We performed a systematic review and meta-analysis of trials evaluating methionine-containing antioxidants in CP. PATIENT AND METHODS: Literature search was conducted in Medline/Pubmed, EMBASE, and Cochrane databases...
March 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Felipe R Bruniera, Felipe M Ferreira, Luiz R M Savioli, Marcelo R Bacci, David Feder, Edimar C Pereira, Mavilde L G Pedreira, Maria A S Peterlini, Fábio F Perazzo, Ligia A Azzalis, Paulo C P Rosa, Virginia B C Junqueira, Monica A Sato, Fernando L A Fonseca
Vancomycin (VCM) is indicated in combat against Gram-positive infections, but it is not considered a first-choice drug because of its adverse effects. It is believed that oxidative stress is the primary mechanism of endothelial injury and the consequent VCM toxicity, which varies from phlebitis to nephrotoxicity. Moreover, dose recommendations, dilution, rates and types of infusion are still controversial. The aim of this study was to determine the effect of different VCM dilutions in endothelial, liver and kidney injuries by biochemical parameters and histopathological analysis...
December 2014: Anais da Academia Brasileira de Ciências
Alessio Alesci, Andrea Salvo, Eugenia Rita Lauriano, Teresa Gervasi, Deborah Palombieri, Maurizio Bruno, Simona Pergolizzi, Nicola Cicero
The effect of astaxanthin (3,3'-dihydroxy-s-carotene-4,4'-dione) on alcohol-induced morphological changes in Carassius auratus, as an experimental model, was determined. The yeast Phaffia rhodozyma was used as a source of astaxanthin. The animals were divided into three groups for 30 days: one group was treated with ethanol at a dose of 1.5% mixed in water, the second one with EtOH 1.5% and food enriched with astaxanthin from P. rhodozyma, and the third was a control group. After a sufficient experimental period, the samples were processed using light microscopy and evaluated by histomorphological and histochemical staining, and the data were supported by immunohistochemical analysis, using a wide range of antibodies, such as calbindin, vimentin and alpha-smooth muscle actin...
2015: Natural Product Research
Gabriella M Anic, Stephanie J Weinstein, Alison M Mondul, Satu Männistö, Demetrius Albanes
OBJECTIVES: Vitamin D may prolong cancer survival by inhibiting tumor progression and metastasis, however, there are limited epidemiologic studies regarding the association between circulating 25-hydroxyvitamin D (25(OH)D) and lung cancer survival. The aim of this study was to examine the relationship between serum 25(OH)D and lung cancer specific survival and to evaluate whether vitamin D binding protein (DBP) concentration modified this association. MATERIALS AND METHODS: 25(OH)D and DBP were measured in fasting serum samples from 500 male lung cancer cases in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study...
December 2014: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Saeed R Khan
Calcium oxalate (CaOx) kidney stones are formed attached to Randall's plaques (RPs) or Randall's plugs. Mechanisms involved in the formation and growth are poorly understood. It is our hypothesis that stone formation is a form of pathological biomineralization or ectopic calcification. Pathological calcification and plaque formation in the body is triggered by reactive oxygen species (ROS) and the development of oxidative stress (OS). This review explores clinical and experimental data in support of ROS involvement in the formation of CaOx kidney stones...
September 1, 2014: Translational Andrology and Urology
Christopher Kim, Bryan A Bassig, Wei Jie Seow, Wei Hu, Mark P Purdue, Wen-Yi Huang, Chin-San Liu, Wen-Ling Cheng, Satu Männistö, Roel Vermeulen, Stephanie J Weinstein, Unhee Lim, H Dean Hosgood, Matthew R Bonner, Neil E Caporaso, Demetrius Albanes, Qing Lan, Nathaniel Rothman
BACKGROUND: Mitochondrial DNA copy number (mtDNA CN) may be modified by mitochondria in response to oxidative stress. Previously, mtDNA CN was associated with non-Hodgkin lymphoma (NHL) risk, particularly chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). We conducted a replication study in the Prostate, Lung, Colorectal, and Ovarian (PLCO) study and pooled with published ATBC (Alpha-Tocopherol, Beta-Carotene) data. METHODS: In PLCO, 292 NHL cases (95 CLL/SLL cases) and 301 controls were pooled with 142 NHL cases (47 CLL/SLL cases) and 142 controls from ATBC...
January 2015: Cancer Epidemiology, Biomarkers & Prevention
Christopher Kim, Bryan A Bassig, Wei Jie Seow, Wei Hu, Mark P Purdue, Xiao-Ou Shu, Wen-Yi Huang, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Yong-Bing Xiang, Bu-Tian Ji, Yu-Tang Gao, Wong-Ho Chow, Satu Männistö, Stephanie J Weinstein, Demetrius Albanes, Wei Zheng, H Dean Hosgood, Unhee Lim, Nathaniel Rothman, Qing Lan
BACKGROUND: We previously reported that higher levels of mitochondrial DNA copy number (mtDNA CN) were associated with lung cancer risk among male heavy smokers (i.e., ≥20 cigarettes per day) in the Alpha-Tocopherol Beta-Carotene (ATBC) study. Here, we present two additional prospective investigations nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial and the Shanghai Women's Health Study (SWHS), and pooled with previously published data from ATBC. MATERIALS: All DNA were extracted from peripheral whole blood samples using the phenol-chloroform method, and mtDNA CN was assayed by fluorescence-based qPCR...
December 2014: Cancer Epidemiology, Biomarkers & Prevention
Athanasios Pantavos, Rikje Ruiter, Edith F Feskens, Catherine E de Keyser, Albert Hofman, Bruno H Stricker, Oscar H Franco, Jessica C Kiefte-de Jong
Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated with breast cancer risk. Data was used from women participating in the Rotterdam Study, a prospective cohort study among subjects aged 55 years and older (N = 3,209). FRAP scores and antioxidant intake (i...
May 1, 2015: International Journal of Cancer. Journal International du Cancer
Betty J Burri
Beta-cryptoxanthin is a common carotenoid that is found in fruit, and in human blood and tissues. Foods that are rich in beta-cryptoxanthin include tangerines, persimmons and oranges. Beta-cryptoxanthin has several functions that are important for human health, including roles in antioxidant defense and cell-to-cell communication. Most importantly, beta-cryptoxanthin is a precursor of vitamin A, which is an essential nutrient needed for eyesight, growth, development and immune response. We evaluate the evidence for beta-cryptoxanthin as a vitamin A-forming carotenoid in this paper...
July 2015: Journal of the Science of Food and Agriculture
Alison M Mondul, Steven C Moore, Stephanie J Weinstein, Satu Männistö, Joshua N Sampson, Demetrius Albanes
Although prostate cancer is the most commonly diagnosed cancer among men in developed populations, recent recommendations against routine prostate-specific antigen screening have cast doubt on its utility for early detection. We compared the metabolomic profiles of prospectively collected fasting serum from 74 prostate cancer cases and 74 controls selected from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers. Circulating 1-stearoylglycerol (1-SG, or 1-monostearin) was statistically significantly inversely associated with risk of prostate cancer after Bonferroni correction for multiple comparisons (i...
October 1, 2014: Metabolomics: Official Journal of the Metabolomic Society
Natalie Hope, Anuj Bellare
BACKGROUND: Ultrahigh-molecular-weight polyethylene (UHMWPE) is subjected to radiation crosslinking to form highly crosslinked polyethylene (HXLPE), which has improved wear resistance. First-generation HXLPE was subjected to thermal treatment to reduce or quench free radicals that can induce long-term oxidative degeneration. Most recently, antioxidants have been added to HXLPE to induce oxidative resistance rather than by thermal treatment. However, antioxidants can interfere with the efficiency of radiation crosslinking...
March 2015: Clinical Orthopaedics and related Research
Margaret E Wright, Demetrius Albanes, Ann B Moser, Stephanie J Weinstein, Kirk Snyder, Satu Männistö, Peter H Gann
Phytanic acid is a saturated branched-chain fatty acid found predominantly in red meat and dairy products, and may contribute to the elevated risks of prostate cancer associated with higher consumption of these foods. Pristanic acid is formed during peroxisomal oxidation of phytanic acid, and is the direct substrate of α-Methyl-CoA-Racemase (AMACR)--an enzyme that is consistently overexpressed in prostate tumors relative to benign tissue. We measured phytanic and pristanic acids as percentages of total fatty acids by gas chromatography-mass spectrometry in prediagnostic blood samples from 300 prostate cancer cases and 300 matched controls, all of whom were participants in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study supplementation trial and follow-up cohort...
December 2014: Cancer Medicine
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