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https://www.readbyqxmd.com/read/28812870/antifouling-thermoplastic-composites-with-maleimide-encapsulated-in-clay-nanotubes
#1
Ye Fu, Congcong Gong, Wencai Wang, Liqun Zhang, Evgenii Ivanov, Yuri M Lvov
An antifouling ethylene-vinyl acetate copolymer (EVA) with halloysite clay nanotubes loaded with maleimide (TCPM) is prepared. Such encapsulation allowed for extended release of TCPM and a long-lasting, efficient protection of the coated surface against marine microorganisms proliferation. Halloysite also induces the composite's anisotropy due to parallel alignment of the nanotubes. The maleimide loaded halloysite incorporated into the polymer matrix allowed for 12-month release of the bacterial inhibitor preventing fouling; it is much longer than the 2-3 month protection when TCPM is directly admixed into EVA...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812169/bond-strength-of-etch-and-rinse-and-self-etch-adhesive-systems-to-enamel-and-dentin-irradiated-with-a-novel-co2-9-3%C3%A2-%C3%AE-m-short-pulsed-laser-for-dental-restorative-procedures
#2
Peter Rechmann, N Bartolome, R Kinsel, R Vaderhobli, B M T Rechmann
The objective of this study was to evaluate the influence of CO2 9.3 μm short-pulsed laser irradiation on the shear bond strength of composite resin to enamel and dentin. Two hundred enamel and 210 dentin samples were irradiated with a 9.3 µm carbon dioxide laser (Solea, Convergent Dental, Inc., Natick, MA) with energies which either enhanced caries resistance or were effective for ablation. OptiBond Solo Plus [OptiBondTE] (Kerr Corporation, Orange, CA) and Peak Universal Bond light-cured adhesive [PeakTE] (Ultradent Products, South Jordan, UT) were used...
August 15, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28811592/high-performance-therapeutic-quercetin-doped-adhesive-for-adhesive-dentin-interfaces
#3
Hongye Yang, Kang Li, Huiyi Yan, Siying Liu, Yake Wang, Cui Huang
Almost half of dental restorations have failed in less than 10 years, and approximately 60% of practice time has been consumed to replace these dental restorations. As such, contemporary dentin adhesives should be modified to treat secondary caries and prevent the degradation of adhesive-dentin interfaces. To achieve this goal, we developed a versatile therapeutic adhesive in the present study by incorporating quercetin, which is a naturally derived plant extract, into a commercial adhesive at three concentrations (100, 500 and 1000 µg/mL)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810910/comprehensive-evaluation-of-gene-expression-signatures-in-response-to-electroacupuncture-stimulation-at-zusanli-st36-acupoint-by-transcriptomic-analysis
#4
Jing-Shan Wu, Hsin-Yi Lo, Chia-Cheng Li, Feng-Yuan Chen, Chien-Yun Hsiang, Tin-Yun Ho
BACKGROUND: Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been clarified. METHODS: Here we applied transcriptomic analysis to explore the gene expression signatures after EA stimulation. Mice were applied EA stimulation at ST36 for 15 min and nine tissues were collected three hours later for microarray analysis...
August 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28810836/suppression-of-agr2-in-a-tgf-%C3%AE-induced-smad-regulatory-pathway-mediates-epithelial-mesenchymal-transition
#5
Lucia Sommerova, Eva Ondrouskova, Borivoj Vojtesek, Roman Hrstka
BACKGROUND: During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representing an essential step of tumor progression towards metastatic state. AGR2 protein was shown to regulate several cancer-associated processes including cellular proliferation, survival and drug resistance. METHODS: The expression of AGR2 was analyzed in cancer cell lines exposed to TGF-β alone or to combined treatment with TGF-β and the Erk1/2 inhibitor PD98059 or the TGF-β receptor specific inhibitor SB431542...
August 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28809421/-reactive-nano-complex-coated-medical-cotton-a-facile-avenue-for-tailored-release-of-small-molecules
#6
Adil Majeed Rather, Sulendar Mahato, Kousik Maji, Neeha Gogoi, Uttam Manna
Controlled and sustained release of drug-like small molecules in an aqueous medium still remains a challenging problem due to rapid infiltration of liquid water in most reported drug release systems. However, internal-superhydrophobicity with an antifouling property extending beyond the surface of a material recently has been recognized as a potential avenue for sustained and extended release of drug-like small molecules. Sluggish removal of metastable trapped air in a superhyrophobic material provides a basis to achieve extended release of encapsulated small molecules...
August 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/28809108/dual-regulations-of-thermo-sensitive-heparin-poloxamer-hydrogel-using-%C3%AE%C2%B5-polylysine-bioadhesivity-and-controlled-kgf-release-for-enhancing-wound-healing-of-endometrial-injury
#7
He-Lin Xu, Jie Xu, Bi-Xin Shen, Si-Si Zhang, Bing-Hui Jin, Qun-Yan Zhu, De-Li ZhuGe, Xue-Qing Wu, Jian Xiao, Yingzheng Zhao
ydrogel was not only used as an effective support matrix to prevent intrauterine adhesion (IUA) after endometrial injury but also served as scaffold to sustain release of some therapeutics, especially growth factor. However, because of the rapid turnover of the endometrial mucus, the poor retention and bad absorption of therapeutic agents in damaged endometrial cavity were two important factors hindering their pharmacologic effect. Herein, a mucoadhesive hydrogel was described by using heparin-modified poloxamer (HP) as the matrix material and ε-polylysine (EPL) as functional excipient...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28807808/safety-and-efficacy-of-amnion-graft-in-preventing-reformation-of-intra-uterine-adhesions
#8
Xuebing Peng, TinChiu Li, Yuting Zhao, Yan Guo, Enlan Xia
OBJECTIVE: To determine the safety and efficacy of amnion graft in the prevention of recurrence of intrauterine adhesions after hysteroscopic adhesiolysis in women with severe intrauterine adhesions. DESIGN: Retrospective matched cohort study including 120 patients treated during 62 months (Canadian Task Force classification II-2). SETTING: Tertiary referral center. PATIENTS: A total of one hundred and twenty patients who underwent intrauterine adhesiolysis for severe intrauterine adhesion, forty patients in the treatment group, eighty patients in the control group matched for age and adhesion scores...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28807377/crem-transgene-mice-an-animal-model-of-atrial-fibrillation-and-thrombogenesis
#9
A Bukowska, M Felgendreher, B Scholz, C Wolke, J S Schulte, E Fehrmann, E Wardelmann, M D Seidl, U Lendeckel, K Himmler, A Gardemann, A Goette, F U Müller
BACKGROUND: The molecular pathomechanisms underlying atrial thrombogenesis are multifactorial and still require detailed investigations. Transgenic mice with cardiomyocyte-directed expression of the transcriptional repressor CREM-IbΔC-X (CREM-TG) represent an experimental model of atrial fibrillation (AF) that shows a gradual, age-dependent progression from atrial ectopy to persistent AF. Importantly, this model develops biatrial thrombi. The molecular characteristics related to the thrombogenesis in CREM-TG mice have not been studied, yet...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28807051/mesenchymal-stromal-cells-ameliorate-oxidative-stress-induced-islet-endothelium-apoptosis-and-functional-impairment-via-wnt4-%C3%AE-catenin-signaling
#10
Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H Shen, Xinguo Hou, Li Chen
BACKGROUND: Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protecting the islets from the infiltration of immune cells and secondary inflammatory attack. Mesenchymal stromal cell (MSC)-based therapies have been proven to promote angiogenesis of the islets; however, the underlying mechanism for the protective role of MSCs in the islet endothelium is still vague...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28804848/laboratory-testing-for-von-willebrand-factor-factor-viii-binding-for-2n-vwd
#11
Soma Mohammed, Emmanuel J Favaloro
Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for the VWF-related disorders requires assessment of both VWF level and VWF activity, the latter requiring multiple assays because of the many functions carried out by VWF to help prevent bleeding. The current paper describes a protocol for assessment of VWF activity by means of VWF: factor VIII binding (VWF:FVIIIB)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28804846/laboratory-testing-for-von-willebrand-factor-ristocetin-cofactor-vwf-rco
#12
Soma Mohammed, Emmanuel J Favaloro
von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for these VWF-related disorders requires assessment of both VWF level and VWF activity, the latter requiring multiple assays because of the many functions carried out by VWF to help prevent bleeding. The current paper describes several protocols for assessment of VWF activity by means of VWF ristocetin cofactor (VWF:RCo)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28804845/laboratory-testing-for-von-willebrand-factor-collagen-binding-vwf-cb
#13
Emmanuel J Favaloro, Soma Mohammed
Von Willebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders develop due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF). Laboratory testing for the VWF-related disorders requires assessment of both VWF level and VWF activity, the latter requiring multiple assays because of the many functions carried out by VWF to help prevent bleeding. This chapter describes several protocols for assessment of VWF activity by means of VWF collagen binding (VWF:CB)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28803898/electrospun-fibrous-membranes-featuring-sustained-release-of-ibuprofen-reduce-adhesion-and-improve-neurological-function-following-lumbar-laminectomy
#14
Shen Liu, Guoqing Pan, Guangwang Liu, José das Neves, Sa Song, Shuai Chen, Bangjun Cheng, Zhiyong Sun, Bruno Sarmento, Wenguo Cui, Cunyi Fan
Electrospun fibrous membranes provide suitable physical anti-adhesion barriers for reducing tissue anti-adhesion following surgery. However, often during the biodegradation process, these barriers trigger inflammation and cause a foreign body reaction with subsequent decrease in anti-adhesion efficacy. Here, a facile strategy comprising the incorporation of ibuprofen (IBU) into implantable membranes and its sustained release was proposed in order to improve anti-adhesion effects and neurological outcomes, namely to prevent failed back surgery syndrome (FBSS)...
August 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28803895/periderm-life-cycle-and-function-during-orofacial-and-epidermal-development
#15
REVIEW
Nigel L Hammond, Jill Dixon, Michael J Dixon
Development of the secondary palate involves a complex series of embryonic events which, if disrupted, result in the common congenital anomaly cleft palate. The secondary palate forms from paired palatal shelves which grow initially vertically before elevating to a horizontal position above the tongue and fusing together in the midline via the medial edge epithelia. As the epithelia of the vertical palatal shelves are in contact with the mandibular and lingual epithelia, pathological fusions between the palate and the mandible and/or the tongue must be prevented...
August 10, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28803215/structural-tribological-and-mechanical-properties-of-the-hind-leg-joint-of-a-jumping-insect-using-katydids-to-inform-bioinspired-lubrication-systems
#16
Jun Kyun Oh, Spencer T Behmer, Richelle Marquess, Cengiz Yegin, Ethan A Scholar, Mustafa Akbulut
This study investigates the structural properties of the hind leg femur-tibia joint in adult katydids (Orthoptera: Tettigoniidae), including its tribological and mechanical properties. It is of particular interest because the orthopteran (e.g., grasshoppers, crickets, and katydids) hind leg is highly specialized for jumping. We show that the katydid hind leg femur-tibia joint had unique surfaces and textures, with a friction coefficient (μ) at its coupling surface of 0.053 ± 0.001. Importantly, the sheared surfaces at this joint showed no sign of wear or damage, even though it had undergone thousands of external shearing cycles...
August 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28802579/atorvastatin-prevents-endothelial-dysfunction-in-high-glucose-condition-through-skp2-mediated-degradation-of-foxo1-and-icam-1
#17
Jonghanne Park, Injoo Hwang, Sung-Jean Kim, Seock-Won Youn, Jin Hur, Hyo-Soo Kim
OBJECTIVE: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin has been reported to exert vasculo-protective action in diabetes. We investigated the vasculo-protective mechanism of atorvastatin by evaluating its effect on two major pathogenic molecules, FOXO1 and ICAM1, mediated by S-phase kinase-associated protein 2 (Skp2) in diabetic endothelial dysfunction. APPROACH AND RESULTS: [1] FOXO1: Hyperglycemic condition increased FOXO1 protein level in endothelial cells, which was reversed by atorvastatin...
August 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28801924/foramen-epiploicum-mesh-closure-femc-through-a-ventral-midline-laparotomy
#18
T van Bergen, A Rötting, P Wiemer, S Schauvliege, K Vanderperren, F Ugahary, A Martens
BACKGROUND: Preventive laparoscopic closure of the epiploic foramen (EF) has previously been described, but methods for EF closure during laparotomy for treatment of colic are lacking. OBJECTIVES: To describe the Foramen Epiploicum Mesh Closure (FEMC) technique through a ventral midline laparotomy in horses under general anaesthesia and its outcome. STUDY DESIGN: Terminal surgical experiment and in vivo study. METHODS: In a pilot study a standard ventral midline laparotomy was performed under general anaesthesia in 10 experimental horses and a three-dimensional expandable diabolo-shaped mesh construct was manually introduced through the EF into the omental vestibule...
August 12, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28798466/minimally-invasive-direct-restorations-a-practical-guide
#19
L Mackenzie, A Banerjee
The primary objectives of minimum intervention dentistry (MID) are to prevent or arrest active disease using non-operative management techniques. However, patients commonly present with cavitated caries lesions or failed restorations that are in need of operative intervention. Although much of clinical practice is devoted to preventing and managing the effects of caries and subsequent failure of the tooth-restoration complex, the clinical survival of restorations is often poor and becomes significantly worse as they increase in size and complexity...
August 11, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28797761/tail-vein-injection-of-mmldl-upregulates-mouse-mesenteric-artery-etb-receptors-via-activation-of-the-erk1-2-pathway
#20
Yang Liu, Xiao-Lan Chen, Cang-Bao Xu, Lei Cao, Jie Lin, Gen Chen, Jie Li
Minimally modified low density lipoprotein (mmLDL) is a risk factor for cardiovascular disease. This study investigated the effect of mmLDL on mouse mesenteric artery endothelin type B (ETB) receptors and its molecular mechanism. Mice were injected with normal saline (NS group), mmLDL in the tail vein (mmLDL group), or with both mmLDL and an intraperitoneal injection of the ERK1/2 pathway-specific inhibitor U0126 (mmLDL+U0126 group). The dose-response curve of mesenteric artery contraction induced by sarafotoxin 6c (S6c), the ETB receptor agonist, was measured using a sensitive myograph system...
August 7, 2017: Vascular Pharmacology
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