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lycopene

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https://www.readbyqxmd.com/read/28531804/protective-effect-and-mechanism-of-lycopene-on-endothelial-progenitor-cells-epcs-from-type-2-diabetes-mellitus-rats
#1
Yao-Chi Zeng, Li-Sheng Peng, Liyuan Zou, Shu-Fen Huang, Yi Xie, Gui-Ping Mu, Xue-Hui Zeng, Xi-Lin Zhou, Ya-Chi Zeng
Endothelial progenitor cells (EPCs), widely existing in bone marrow and peripheral blood, are involved in the repair of injured vascular endothelium and angiogenesis which are important to diabetic mellitus (DM) patients with vascular complications. The number and the function of EPCs are related to the advanced glycation end products (AGEs) generated in DM patients. Lycopene (Lyc) is an identified natural antioxidant that protects EPCs under the microenvironment of AGEs from damage. However, the underlying mechanism remains unclear...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28530601/storage-stability-of-traditional-tunisian-butter-enriched-with-antioxidant-extract-from-tomato-processing-by-products
#2
Yousra Abid, Samia Azabou, Mourad Jridi, Ibtihel Khemakhem, Mohamed Bouaziz, Hamadi Attia
Traditional Tunisian butter (TTB) is one of the most appreciated dairy products in Tunisia. Herein, the storage stability of TTB enriched with antioxidants from tomato processing by-products (TPB) was evaluated during 60days of storage at 4°C. TPB extract contains significant amounts of lycopene and phenolics. TTB enriched with 400mg of TPB extract/kg of TTB revealed the lowest peroxide values at all the determination intervals. Adding 400mg of TPB extract/kg of TTB did not exhibit any undesired effect on lactic bacteria which are necessary for development of aroma and chemical properties of TTB...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28527371/lutein-exerts-anti-inflammatory-effects-in-patients-with-coronary-artery-disease
#3
Rosanna W S Chung, Per Leanderson, Anna K Lundberg, Lena Jonasson
BACKGROUND AND AIMS: Many coronary artery disease (CAD) patients exhibit chronic low-grade inflammation. Carotenoids are anti-oxidants with potential anti-inflammatory properties. Here, we first assessed relationships between interleukin (IL)-6 and individual carotenoids in plasma from CAD patients. Based on the results, we proceeded to assess anti-inflammatory effects of one carotenoid, lutein, in peripheral blood mononuclear cells (PBMCs) from CAD patients. METHODS: Lutein + zeaxanthin (isomers with lutein being dominant), β-cryptoxanthin, lycopene, α- and β-carotene and IL-6 were measured in plasma from 134 patients with stable angina (SA) and 59 patients with acute coronary syndrome...
May 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28520939/dietary-intake-of-antioxidant-vitamins-and-carotenoids-and-risk-of-developing-active-tuberculosis-in-a-prospective-population-based-cohort
#4
Avril Z Soh, Cynthia B E Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
Antioxidants may protect against oxidative stress, which is associated with tuberculosis disease. However, direct evidence for the protective association between dietary antioxidants and tuberculosis incidence in humans has been lacking. The relation between intake of antioxidant vitamins (A, C, D, E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein) and tuberculosis incidence was examined in the Singapore Chinese Health Study, a prospective cohort of 63,257 adults 45-74 years old enrolled during 1993-1998...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28494764/possible-benefits-of-tomato-juice-consumption-a-pilot-study-on-irradiated-human-lymphocytes-from-healthy-donors
#5
Ayumi Nakamura, Chieko Itaki, Ayako Saito, Toko Yonezawa, Koichi Aizawa, Ayumi Hirai, Hiroyuki Suganuma, Tomisato Miura, Yasushi Mariya, Siamak Haghdoost
BACKGROUND: Reactive oxygen species (ROS) mediate much of the DNA damage caused by ionizing radiation. Among carotenoids, lycopene and β-carotene, present in tomato juice, are known to be strong radical scavengers. The aim of the study was to investigate the effect of tomato juice intake on the levels of DNA damage and oxidative stress in human whole blood induced by in vitro exposure to X-rays. METHODS: Ten healthy adults were asked to drink 190 g of tomato juice, containing 17 mg lycopene and 0...
May 12, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28490387/serum-carotenoid-and-retinol-levels-in-african-caribbean-tobagonian-men-with-high-prostate-cancer-risk-in-comparison-with-african-american-men
#6
Alicia C McDonald, Clareann H Bunker, Jay Raman, John Richie, Alan L Patrick
Black men are known to have a higher risk for prostate cancer (PC). Carotenoids and retinol, linked to PC, have not been compared in different black populations at risk. We examined serum carotenoid and retinol levels between PC-free African-Caribbean (AC) Tobagonian men with a high PC risk (high-grade prostatic intraepithelial neoplasia, atypical foci or repeated abnormal PC screenings) and African-American (AA) men with elevated serum prostate-specific antigen (PSA) levels (≥4 ng/ml). AC men who participated in the 2003 lycopene clinical trial and AA men who participated in the 2001-2006 National Health and Nutrition Examination Survey were compared...
May 11, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28490080/utilization-of-watermelon-pulp-for-lycopene-extraction-by-response-surface-methodology
#7
Davinder Pal Singh Oberoi, Dalbir Singh Sogi
Lycopene extraction was optimized from watermelon pulp using response surface methodology using independent variables:solvent/meal ratio (4:1-12:1v/w), number of extractions (1-5), temperature (20-60°C) and extraction time (4-20min). Watermelon pulp had 59.95mglycopene/100g on fresh weight basis. The experimental values of lycopene with selected combinations of independent variables were 8.20-59.17mg/100g on fresh weight basis. The second order model obtained revealed a coefficient of determination (R(2)) of 0...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28490055/carotenoid-bioaccessibility-and-the-relation-to-lipid-digestion-a-kinetic-study
#8
Leonard Mutsokoti, Agnese Panozzo, Andrea Pallares Pallares, Swati Jaiswal, Ann Van Loey, Tara Grauwet, Marc Hendrickx
The micellar incorporation of carotenoids (lycopene, α- and β-carotene) and lipid digestion products (free fatty acids, FFAs, and monoacylglycerides, MAGs) during in vitro digestion of oil-in-water emulsions was investigated by a kinetic approach. A fractional conversion model could adequately describe the hydrolysis of triacylglycerides, formation of FFAs and MAGs, and micellar incorporation of carotenoids, FFAs and MAGs. The release of FFAs and MAGs from TAGs proceeded faster than their incorporation into micelles...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28486774/dietary-intake-of-selected-nutrients-and-persistence-of-hpv-infection-in-men
#9
Raíssa do Vale C Lopes, Juliana A Teixeira, Dirce Marchioni, Luisa L Villa, Anna R Giuliano, Maria Luiza Baggio, Regina M Fisberg
Human papillomavirus (HPV) infection is a common sexually transmitted disease. Although often transitory, persistent oncogenic HPV infection may progress to a precursor lesion and, if not treated, can further increase the risk of cancer. The purpose of this study was to investigate the relation between dietary intake and HPV persistent infection in men of a Brazilian cohort. The study population consisted of 1248 men from the Brazilian cohort of the HIM (HPV in Men) Study, ages 18 to 70 years, who completed a quantitative food frequency questionnaire...
May 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28484430/isoprenoid-pyrophosphate-dependent-transcriptional-regulation-of-carotenogenesis-in-corynebacterium-glutamicum
#10
Nadja A Henke, Sabine A E Heider, Silvin Hannibal, Volker F Wendisch, Petra Peters-Wendisch
Corynebacterium glutamicum is a natural producer of the C50 carotenoid decaprenoxanthin. The crtEcg0722crtBIYEb operon comprises most of its genes for terpenoid biosynthesis. The MarR-type regulator encoded upstream and in divergent orientation of the carotenoid biosynthesis operon has not yet been characterized. This regulator, named CrtR in this study, is encoded in many actinobacterial genomes co-occurring with terpenoid biosynthesis genes. CrtR was shown to repress the crt operon of C. glutamicum since DNA microarray experiments revealed that transcript levels of crt operon genes were increased 10 to 70-fold in its absence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28481314/inferring-the-genetic-determinants-of-fruit-colors-in-tomato-by-carotenoid-profiling
#11
Hee Ju Yoo, Woo Jung Park, Gyu-Myung Lee, Chang-Sik Oh, Inhwa Yeam, Dong-Chan Won, Chang Kil Kim, Je Min Lee
Carotenoids are essential for plant and animal nutrition, and are important factors in the variation of pigmentation in fruits, leaves, and flowers. Tomato is a model crop for studying the biology and biotechnology of fleshy fruits, particularly for understanding carotenoid biosynthesis. In commercial tomato cultivars and germplasms, visual phenotyping of the colors of ripe fruits can be done easily. However, subsequent analysis of metabolic profiling is necessary for hypothesizing genetic factors prior to performing time-consuming genetic analysis...
May 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28474355/antioxidant-activity-and-bioactive-compound-contents-before-and-after-in-vitro-digestion-of-new-tomato-hybrids
#12
Giuseppina Tommonaro, Giovanna Speranza, Rocco De Prisco, Carmine Iodice, Egle Crudele, Gennaro Roberto Abbamondi, Barbara Nicolaus
BACKGROUND: The antioxidant properties and bioactive compound contents of fresh new tomato hybrids before and after in vitro digestion was investigated. To this aim the antioxidant activities of lipophilic, hydrophilic, and polyphenolic extracts of tomato hybrids were determined by ABTS [2,20-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)], DMPD (N,N-dimethyl-p-phenylenediamine dihydrochloride), and DPPH (2,2-diphenyl-1-picrylhydrazyl) methods, respectively, while the bioactive compound contents were estimated by means of Folin-Ciocalteu (polyphenols), pH differential (anthocyanins) and HPLC (lycopene and β-carotene) methods...
May 5, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28472825/lycopene-improves-insulin-sensitivity-through-inhibition-of-stat3-srebp-1c-mediated-lipid-accumulation-and-inflammation-in-mice-fed-a-high-fat-diet
#13
Zhaohui Zeng, Wang He, Zhen Jia, Shu Hao
In the past few years, metabolic disorders, such as type 2 diabetes and metabolic syndrome, has reached global prevalence. Lycopene is one of the major carotenoids in tomatoes, watermelons, red grapefruits, and guava. In the current study, using high fat diet (HFD)-fed mice, we investigated the effect of Lycopene on insulin resistance. We showed that diet containing Lycopene significantly prevented HFD-induced increase of fasting blood glucose and insulin level, glucose and insulin intolerance, and decrease of hepatic glycogen content...
May 4, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28471231/the-effects-of-lycopene-on-methotrexate-induced-liver-injury-in-rats
#14
Y Yucel, E Oguz, S Kocarslan, F Tatli, O Gozeneli, A Seker, H Sezen, H Buyukaslan, A Aktumen, A Ozgonul, A Uzunkoy, N Aksoy
BACKGROUND: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx) induced liver toxicity in rats. METHODS: Twenty-eight male Sprague-Dawley rats were divided into four equal groups: control, Lyc, Mtx and Mtx-L: Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for ten days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28469951/functional-foods-and-their-role-in-cancer-prevention-and-health-promotion-a-comprehensive-review
#15
REVIEW
Mohammad Aghajanpour, Mohamad Reza Nazer, Zia Obeidavi, Mohsen Akbari, Parya Ezati, Nasroallah Moradi Kor
Following cardiovascular disease, cancer is the second leading cause of death in most affluent countries. The 13.3 million new cases of cancer in 2010 were predicted to cost US$ 290 billion, but the total costs were expected to increases to US$ 458 billion in the year 2030 on basis of World Economic Forum in 2011. More than half of all cancer cases and deaths worldwide are consider being preventable. From its inception, the disease control priorities series has focused attention on delivering efficacious health interventions that can result in dramatic reductions in mortality and disability at relatively modest cost...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28468699/determination-of-lutein-and-%C3%AE-carotene-in-infant-formula-and-adult-nutritionals-by-ultra-high-performance-liquid-chromatography-single-laboratory-validation-first-action-2016-13
#16
Gregory L Hostetler
An ultra-HPLC method for the determination of lutein and β-carotene in infant formula and adult nutritionals was validated using both unfortified and fortified samples provided by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN). All experiments showed separation of all-trans-lutein and β-carotene from their major cis isomers, apocarotenal, α-carotene, lycopene, and zeaxanthin. Samples spiked with all-trans-lutein and β-carotene showed no isomerization during sample preparation...
May 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28467233/moringa-oleifera-from-cambodia-ameliorates-oxidative-stress-hyperglycemia-and-kidney-dysfunction-in-type-2-diabetic-mice
#17
Yujiao Tang, Eun-Ju Choi, Weon Cheol Han, Mirae Oh, Jin Kim, Ji-Young Hwang, Pyo-Jam Park, Sang-Ho Moon, Yon-Suk Kim, Eun-Kyung Kim
Recent reports have shown the antidiabetic effect of Moringa oleifera from various parts of the world. However, M. oleifera from Cambodia has never determined. Therefore, the aim of this study was to assess the antidiabetic effect of M. oleifera extract from Cambodia. The leaf ethanolic extract contained flavonoids (31.90 mg/mL), polyphenols (53.03 mg/mL), lycopene (0.042 mg/mL), and ß-carotene (0.170 mg/mL), and possessed 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide, and hydroxyl radical scavenging activities of 92...
May 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28465213/metabolomic-changes-and-metabolic-responses-to-expression-of-heterologous-biosynthetic-genes-for-lycopene-production-in-yarrowia-lipolytica
#18
Chen Zhao, Qi Gao, Jun Chen, Liujing Wei, Tadayuki Imanaka, Qiang Hua
The metabolomic studies were conducted for both the engineered lycopene-producing Yarrowia lipolytica strain and the control strain. The changes in metabolome profiling and main pathway abundance of Y. lipolytica with the introduction of heterologous crt genes were investigated by multiple analytical and statistical methods More importantly, the metabolome data were transformed into pathway abundances visualized by a pathway relationship network using Cytoscape software. This network provided a simple way to present the statistical results of pathway abundance and interpret the effects of the crt genes in a metabolic view, and the results highlighted the up-regulation of eight pathways and the down-regulation of three pathways in the lycopene fast production phase...
April 29, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28446545/a-pooled-analysis-of-15-prospective-cohort-studies-on-the-association-between-fruit-vegetable-and-mature-bean-consumption-and-risk-of-prostate-cancer
#19
Joshua Petimar, Kathryn M Wilson, Kana Wu, Molin Wang, Demetrius Albanes, Piet A van den Brandt, Michael B Cook, Graham G Giles, Edward L Giovannucci, Gary G Goodman, Phyllis J Goodman, Niclas Håkansson, Kathy Helzlsouer, Timothy J Key, Laurence N Kolonel, Linda M Liao, Satu Männistö, Marjorie L McCullough, Roger L Milne, Marian L Neuhouser, Yikyung Park, Elizabeth A Platz, Elio Riboli, Norie Sawada, Jeannette M Schenk, Shoichiro Tsugane, Bas Verhage, Ying Wang, Lynne R Wilkens, Alicja Wolk, Regina G Ziegler, Stephanie A Smith-Warner
BACKGROUND: Relationships between fruit, vegetable, and mature bean consumption and prostate cancer risk are unclear. METHODS: We examined associations between fruit and vegetable groups, specific fruits and vegetables, and mature bean consumption and prostate cancer risk overall, by stage and grade, and for prostate cancer mortality in a pooled analysis of 15 prospective cohorts, including 52,680 total cases and 3,205 prostate cancer deaths among 842,149 men. Diet was measured by a food frequency questionnaire or similar instrument at baseline...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28444589/ripening-improves-the-content-of-carotenoid-%C3%AE-tocopherol-and-polyunsaturated-fatty-acids-in-tomato-solanum-lycopersicum-l-fruits
#20
Ramesh Kumar Saini, Ahmad Jawid Zamany, Young-Soo Keum
The tomato fruits during different stages of ripening have been extensively characterized for nutritionally important bioactives; however, changes in fatty acid composition are not available. Thus, in the present study, changes in fatty acid, along with carotenoid and α-tocopherol, were studied during the six stages of ripening. Fruits were harvested at the green, breaker, turning, pink, light red, and red stages, which occurred at means of 30, 35, 40, 46, 50, and 55 days after anthesis (DAE), respectively...
May 2017: 3 Biotech
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