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https://www.readbyqxmd.com/read/28615536/antagonistic-effects-of-lycopene-on-cadmium-induced-hippocampal-dysfunctions-in-autophagy-calcium-homeostatis-and-redox
#1
Fenghua Zhang, Suping Xing, Zongpeng Li
Cadmium (Cd), a widely existed environmental contaminant, was shown to trigger neurotoxicity by regulating autophagy, ion homeostasis and redox. Lycopene (LYC) is a natural substance with potent antioxidant capacity. Nevertheless, little is known about i) the relationship of Cd-induced neurotoxicity and autophagy, ion homeostasis as well as redox in the hippocampus; ii) the role of LYC in the regulation of hippocampal autophagy, ionic balance and antioxidant capacity during Cd exposure. Therefore, this study sought to investigate the Cd exposure-induced hippocampal dysfunctions for neurotoxicity, and the preventive potential of LYC on the hippocampus impairment by reversing the dysfunctions during the exposure...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28615062/metabolic-and-transcriptional-elucidation-of-the-carotenoid-biosynthesis-pathway-in-peel-and-flesh-tissue-of-loquat-fruit-during-on-tree-development
#2
Margarita Hadjipieri, Egli C Georgiadou, Alicia Marin, Huertas M Diaz-Mula, Vlasios Goulas, Vasileios Fotopoulos, Francisco A Tomás-Barberán, George A Manganaris
BACKGROUND: Carotenoids are the main colouring substances found in orange-fleshed loquat fruits. The aim of this study was to unravel the carotenoid biosynthetic pathway of loquat fruit (cv. 'Obusa') in peel and flesh tissue during distinct on-tree developmental stages through a targeted analytical and molecular approach. RESULTS: Substantial changes regarding colour parameters, both between peel and flesh and among the different developmental stages, were monitored, concomitant with a significant increment in carotenoid content...
June 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28609133/carotenoids-biosynthesis-and-cleavage-related-genes-from-bacteria-to-plants
#3
Ming-Hua Liang, Jianhua Zhu, Jian-Guo Jiang
Carotenoids are essential for photosynthesis and photoprotection in photosynthetic organisms and beneficial for human health. Apocarotenoids derived from carotenoid degradation can serve critical functions including hormones, volatiles, and signals. They have been used commercially as food colorants, animal feed supplements, and nutraceuticals for cosmetic and pharmaceutical purposes. This review focuses on the molecular evolution of carotenogenic enzymes and carotenoid cleavage oxygenases (CCOs) from bacteria, fungi, cyanobacteria, algae, and plants...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28605127/serum-carotenoids-and-colorectal-cancer-risk-a-case-control-study-in-guangdong-china
#4
Jing Huang, Min-Shan Lu, Yu-Jing Fang, Ming Xu, Wu-Qing Huang, Zhi-Zhong Pan, Yu-Ming Chen, Cai-Xia Zhang
SCOPE: Previous epidemiological studies on the association between circulating carotenoids and the risk of colorectal cancer drew inconclusive conclusions. This study aimed to examine serum carotenoids in relation to colorectal cancer risk in a Chinese population. METHODS AND RESULTS: One case-control study beginning from July 2010, consecutively recruited 538 eligible colorectal cancer cases and 564 age (5-year interval) and sex frequency-matched controls. Serum levels of α-carotene, β-carotene, β-cryptoxanthin, lycopene and lutein/ zeaxanthin were detected by HPLC...
June 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28599197/tomato-lycopersicon-esculentum-or-lycopene-supplementation-attenuates-ventricular-remodeling-after-myocardial-infarction-through-different-mechanistic-pathways
#5
Bruna L B Pereira, Patrícia P Reis, Fábio E Severino, Tainara F Felix, Mariana G Braz, Flávia R Nogueira, Renata A C Silva, Ana C Cardoso, Maria A M Lourenço, Amanda M Figueiredo, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, Katashi Okoshi, Ana A H Fernandes, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci
The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16)...
June 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28596014/designing-food-structure-and-composition-to-enhance-nutraceutical-bioactivity-to-support-cancer-inhibition
#6
REVIEW
David Julian McClements, Hang Xiao
Many types of bioactive molecules found in foods ("nutraceuticals") have been shown to exert anticancer activities, including curcumin, resveratrol, polyphenols, sulforaphane, anthocyanins, genistein, quercetin and lycopene. The potential health benefits of nutraceuticals are often not realized because of their poor water solubility, chemical instability, adverse taste profile, and low oral bioavailability. Carefully designed food matrices are being developed to overcome these problems. Nutraceuticals can be isolated from their natural environment, and then incorporated into functional foods, often with the help of delivery systems (such as emulsions, nanoemulsions, liposomes, biopolymer nanoparticles, and microgels)...
June 5, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28595495/lipid-based-nanoformulation-of-lycopene-improves-oral-delivery-formulation-optimization-ex-vivo-assessment-and-its-efficacy-against-breast-cancer
#7
Archu Singh, Yub Raj Neupane, Bibhu Prasad Panda, Kanchan Kohli
This study aims at developing an optimized Nanostructured Lipid Carrier (NLC) of Lycopene for efficient absorption following oral administration. The optimized formulation showed an average particle size of 121.9±3.66 nm, Poly dispersity index (PDI) 0.370±0.97 and zeta potential -29.0± 0.83 mV. Encapsulation Efficiency (% EE) and Drug Loading (% DL) was found to be 84.50% ± 4.38 and 9.54% ± 2.65 respectively. In vitro release studies demonstrated the burst release within 4-9 h followed by sustained release over 48 h...
June 9, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28587685/carotenoid-dietary-intakes-and-plasma-concentrations-are-associated-with-heel-bone-ultrasound-attenuation-and-osteoporotic-fracture-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-norfolk-cohort
#8
Richard P G Hayhoe, Marleen A H Lentjes, Angela A Mulligan, Robert N Luben, Kay-Tee Khaw, Ailsa A Welch
Carotenoids are found in abundance in fruit and vegetables, and may be involved in the positive association of these foods with bone health. This study aimed to explore the associations of dietary carotenoid intakes and plasma concentrations with bone density status and osteoporotic fracture risk in a European population. Cross-sectional analyses (n 14 803) of bone density status, using calcaneal broadband ultrasound attenuation (BUA) and longitudinal analyses (n 25 439) of fracture cases were conducted on data from the prospective European Prospective Investigation into Cancer and Nutrition-Norfolk cohort of middle-aged and older men and women...
June 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28585698/lycopene-protects-keratinocytes-against-uvb-radiation-induced-carcinogenesis-via-negative-regulation-of-foxo3a-through-the-mtorc2-akt-signaling-pathway
#9
Ping Chen, Shina Xu, Jinlong Qu
Lycopene, one of the most potent anti-oxidants, has been reported to exhibit potent anti-proliferative properties in a wide range of cancer cells through modulation of the cell cycle and apoptosis. Forkhead box O3a (FOXO3a) plays a pivotal role in modulating the expression of genes involved in cell death. Herein, we investigated the role of FOXO3a signaling in the anti-cancer effects of lycopene. Results showed that lycopene pretreatment attenuated UVB-induced cell hyper-proliferation and promoted apoptosis, accompanied by decreased cyclin-dependent kinase 2 (CDK2) and CDK4 complex in both human keratinocytes and SKH-1 hairless mice...
June 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28578499/thermal-treatment-of-luteolin-7-o-%C3%AE-glucoside-improves-its-immunomodulatory-and-antioxidant-potencies
#10
Mouna Maatouk, Nadia Mustapha, Imen Mokdad-Bzeouich, Hind Chaaban, Besma Abed, Irina Iaonnou, Kamel Ghedira, Mohamed Ghoul, Leila Chekir Ghedira
Phytochemicals extracted from flowers, roots and bark, leaves, and other plant sources have been used extensively throughout human history with varying levels of efficacy in prevention and treatment of disease. Recently, advanced methods for characterization and clinical use of these materials have allowed modern understanding of their properties to be used as immunomodulatory agents that act by enhancement of endogenous cytoprotective mechanisms, avoiding interference with normal physiologic signaling and highly effective medical treatment with minimal adverse side effects...
June 4, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28575160/dynamic-changes-in-methylome-and-transcriptome-patterns-in-response-to-methyltransferase-inhibitor-5-azacytidine-treatment-in-citrus
#11
Jidi Xu, Xia Wang, Hongbo Cao, Haidan Xu, Qiang Xu, Xiuxin Deng
DNA methylation is known to play an important role in various developmental processes in plants. However, there is a general lack of understanding about the possible functions of DNA methylation in fruit trees. Using callus as a model, methylome, transcriptome and metabolite changes were assessed after treatment with the DNA methyltransferase inhibitor 5-azacytidine (5azaC). Genome-wide methylome analysis revealed the demethylation of a diverse of genes, including many genes encoding transcription factors (TFs), genes involved in biological processes, and the up-regulation of a wide range of transposable elements (TEs)...
June 1, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28572959/bioactive-phytochemicals-in-an-aqueous-extract-of-the-leaves-of-talinum-triangulare
#12
Catherine C Ikewuchi, Jude C Ikewuchi, Mercy O Ifeanacho
An aqueous leaf extract of Talinum triangulare was screened for the presence of bioactive molecules, using gas chromatography coupled with pulse and flame ionization detectors. It had high carotenoids; moderate benzoic acid derivatives, hydroxycinnamates and flavonoids; and low terpenes, alkaloids, phytosterols, allicins, glycosides, saponins, and lignans contents. Ten known carotenoids (mainly 50.42% carotene and 33.30% lycopene), nine benzoic acid derivatives (mainly 84.63% ferulic acid and 11.92% vanillic acid), and six hydroxycinnamates (55...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28572940/influence-of-storage-temperature-and-low-temperature-conditioning-on-the-levels-of-health-promoting-compounds-in-rio-red-grapefruit
#13
Priyanka R Chaudhary, Xiang Yu, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
Commercial operations use low-temperature conditioning of citrus fruits to reduce the incidence of chilling injury (CI) during cold storage and quarantine treatments. Rio Red grapefruits (Citrus paradisi Macf) were stored for 12 weeks at 11°C or 5°C; an additional set was temperature conditioned at 16°C for 7 days before storing at 5°C (CD). Every 3 weeks, samples were assessed for chilling injury (CI) and health-promoting compounds such as ascorbic acid, carotenoids, limonoids, flavonoids, and furocoumarins...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28557544/safety-assessment-of-oil-from-pequi-caryocar-brasiliense-camb-evaluation-of-the-potential-genotoxic-and-clastogenic-effects
#14
Giseli Karenina Traesel, Flavio Henrique Souza de Araújo, Luis Henrique Almeida Castro, Fernando Freitas de Lima, Sara Emilia Lima Tolouei Menegati, Priscilla Narciso Justi, Candida Aparecida Leite Kassuya, Claudia Andrea Lima Cardoso, Eliana Janet Sanjinez Argandoña, Silvia Aparecida Oesterreich
Genotoxic data of medicinal plants and functional foods are required as part of the risk assessment by international regulatory agencies. Due to its food consumption and ethnopharmacological relevance, pequi oil (Caryocar brasiliense Camb.) is one of these compounds to be studied. The aim of this study was to evaluate the cytotoxic, genotoxic, and clastogenic effects of the oil from the pulp of C. brasiliense (OPCB) in vivo and in vitro. Initially, the Artemia salina in vitro assay was conducted to determine the cells viability rate of different doses of the OPCB...
May 30, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28554637/encapsulation-of-lycopene-in-chlorella-pyrenoidosa-loading-properties-and-stability-improvement
#15
Chuanfen Pu, Wenting Tang
Aiming to improve the stability of lycopene and incorporate it into a complex nutraceutical, exogenous lycopene-loaded Chlorella pyrenoidosa cells (CPCs) were developed. The complex had an encapsulation yield of 13.06±0.89% and an encapsulation efficiency of 96.31±3.10%. Fluorescence analyses indicated that lycopene was encapsulated in the CPCs. X-ray diffraction, thermogravimetric and differential scanning calorimetric analyses were conducted and compared to those of the non-loaded CPCs, lycopene and their physical mixture...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28541356/food-and-plant-bioactives-for-reducing-cardiometabolic-disease-risk-an-evidence-based-approach
#16
REVIEW
Arrigo F G Cicero, Federica Fogacci, Alessandro Colletti
Cardiovascular diseases (CVDs) are one of the major causes of mortality and disability in Western countries. Prevention is known to be the cornerstone to lessen the incidence of CVDs and also to reduce the economic burden of both the citizen and the healthcare system. "Interventional medicine" certainly puts lifestyle modification as the first therapeutic step, including a healthy diet and physical activity. Secondly, a large body of research individuated a number of food and plant bioactives, which are potentially efficacious in preventing and reducing some highly prevalent CV risk factors, such as hypercholesterolemia, hypertension, vascular inflammation and vascular compliance...
May 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28539740/evaluation-of-antioxidant-hypolipidemic-and-antiatherogenic-property-of-lycopene-and-astaxanthin-in-atherosclerosis-induced-rats
#17
Rajesh Kumar, Kartik Janardan Salwe, Manimekalai Kumarappan
BACKGROUND: Atherosclerosis is one of the major causes of morbidity and mortality in the world. Antioxidants play a major role in prophylaxis and prevention of progression and complications of atherosclerosis. OBJECTIVE: In this study, we are evaluating the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene. MATERIALS AND METHODS: After acclimatization, 24 male SD rats, 8-10 weeks old, 150 ± 10 g, maintained as per CPCSEA guidelines were divided into four groups of six rats each...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28538676/older-australians-can-achieve-high-adherence-to-the-mediterranean-diet-during-a-6-month-randomised-intervention-results-from-the-medley-study
#18
Courtney Davis, Jonathan Hodgson, Janet Bryan, Manohar Garg, Richard Woodman, Karen Murphy
Adherence to a Mediterranean diet (MedDiet) is thought to be achievable in non-Mediterranean regions, but this has yet to be investigated. We aimed to determine if an older Australian population could adhere to a MedDiet for six months. We conducted a randomised, parallel dietary intervention trial with two dietary arms: the Mediterranean diet (MedDiet) group and the habitual diet (HabDiet) control group. A 15-point Mediterranean diet adherence score and food and nutrient intakes were estimated from three-day weighed food records collected at baseline, two and four months...
May 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28534677/modeling-tomato-ripening-based-on-carotenoid-raman-spectroscopy-experimental-versus-kinetic-model
#19
Daniel Martin, Alicia G Gonzalvez, Rocio Mateos Medina, Angel González Ureña
This work reports on a combined experimental and theoretical investigation on the carotenoid Raman signal in several tomato fruits during their postharvest time evolution and ripening. Both resonant (180°) backscattering and polarized (90°) Raman scattering were used to monitor the most prominent bands of carotenoid (lycopene and β-carotene) evolution in different tomato varieties. Relevant findings of the present investigations were that while the depolarization ratio of the ν1 band hardly changed with time, the Raman ν1 band intensity did change showing a similar pattern for all tomatoes investigated...
June 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28531804/protective-effect-and-mechanism-of-lycopene-on-endothelial-progenitor-cells-epcs-from-type-2-diabetes-mellitus-rats
#20
Yao-Chi Zeng, Li-Sheng Peng, Liyuan Zou, Shu-Fen Huang, Yi Xie, Gui-Ping Mu, Xue-Hui Zeng, Xi-Lin Zhou, Ya-Chi Zeng
Endothelial progenitor cells (EPCs), widely existing in bone marrow and peripheral blood, are involved in the repair of injured vascular endothelium and angiogenesis which are important to diabetic mellitus (DM) patients with vascular complications. The number and the function of EPCs are related to the advanced glycation end products (AGEs) generated in DM patients. Lycopene (Lyc) is an identified natural antioxidant that protects EPCs under the microenvironment of AGEs from damage. However, the underlying mechanism remains unclear...
May 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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