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lycopene

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https://www.readbyqxmd.com/read/28345329/lycopene-extracts-from-different-tomato-based-food-products-induce-apoptosis-in-cultured-human-primary-prostate-cancer-cells-and-regulate-tp53-bax-and-bcl-2-transcript-expression
#1
Nathalia da Costa Pereira Soares, Clara Lima Machado, Bruno Boquimpani Trindade, Ingridy Celestino do Canto Lima, Etel Rodrigues Pereira Gimba, Anderson Junger Teodoro, Christina Takiya, Radovan Borojevic
Carotenoids are the main tomato components, especially lycopene. Lycopene is more bioavailable in tomato processed products than in raw tomatos, since formation of lycopene cis-isomers during food processing and storage may increase its biological activity. In the current study, we evaluated the influence of lycopene extracts (5 mg / mL) from different tomato-based food products (paste, sauce, extract and ketchup) on cell viability and apoptosis on primary human prostate cancer cells (PCa cels) for 96h. Using MTT assay, we observed a significant decrease on primary PCa cell viability upon treatment with lycopene extracted from either 4 tomato-based food products...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28333357/dietary-patterns-foods-and-nutrients-in-male-fertility-parameters-and-fecundability-a-systematic-review-of-observational-studies
#2
Albert Salas-Huetos, Mònica Bulló, Jordi Salas-Salvadó
BACKGROUND: Infertility is a global public health issue, affecting 15% of all couples of reproductive age. Male factors, including decreased semen quality, are responsible for ~25% of these cases. The dietary pattern, the components of the diet and nutrients have been studied as possible determinants of sperm function and/or fertility. OBJECTIVE AND RATIONALE: Previous systematic reviews have been made of the few heterogeneous low-quality randomized clinical trials (RCTs) conducted in small samples of participants and investigating the effect of specific nutrients and nutritional supplements on male infertility...
March 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28333071/combined-effects-of-curcumin-and-lycopene-or-bixin-in-yoghurt-on-inhibition-of-ldl-oxidation-and-increases-in-hdl-and-paraoxonase-levels-in-streptozotocin-diabetic-rats
#3
Renata Pires Assis, Carlos Alberto Arcaro, Vânia Ortega Gutierres, Juliana Oriel Oliveira, Paulo Inácio Costa, Amanda Martins Baviera, Iguatemy Lourenço Brunetti
Combination therapy using natural antioxidants to manage diabetes mellitus and its complications is an emerging trend. The aim of this study was to investigate the changes promoted by treatment of streptozotocin (STZ)-diabetic rats with yoghurt enriched with the bioactives curcumin, lycopene, or bixin (the latter two being carotenoids). Antioxidants were administered individually, or as mixtures, and biomarkers of metabolic and oxidative disturbances, particularly those associated with cardiovascular risk, were assessed...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28327526/survivin-and-naip-in-human-benign-prostatic-hyperplasia-protective-role-of-the-association-of-serenoa-repens-lycopene-and-selenium-from-the-randomized-clinical-study
#4
Giuseppe Morgia, Antonio Micali, Mariagrazia Rinaldi, Natasha Irrera, Herbert Marini, Domenico Puzzolo, Antonina Pisani, Salvatore Privitera, Giorgio I Russo, Sebastiano Cimino, Antonio Ieni, Vincenzo Trichilo, Domenica Altavilla, Francesco Squadrito, Letteria Minutoli
Benign prostatic hyperplasia (BPH) treatment includes the apoptosis machinery modulation through the direct inhibition of caspase cascade. We previously demonstrated that Serenoa repens (Ser) with lycopene (Ly) and selenium (Se) reawakened apoptosis by reducing survivin and neuronal apoptosis inhibitory protein (NAIP) levels in rats. The aim of this study was to evaluate the effectiveness of Ser-Se-Ly association on survivin and NAIP expression in BPH patients. Ninety patients with lower urinary tract symptoms (LUTS) due to clinical BPH were included in this randomized, double-blind, placebo-controlled trial...
March 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28323947/effects-of-mixed-carotenoids-on-adipokines-and-abdominal-adiposity-in-children-a-pilot-study
#5
J Atilio Canas, Amanda Lochrie, Amy Galena McGowan, Jobayer Hossain, Christopher Schettino, P Babu Balagopal
Context: Carotenoids have been implicated in the regulation of adipocyte metabolism. Objective: To compare the effects of mixed-carotenoid supplementation (MCS) vs. placebo on adipokines and the accrual of abdominal adiposity in children with obesity. Design and Setting: Randomized (1:1) double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic. Participants: Twenty (6 male and 14 female) children with simple obesity (BMI > 90%); age: 10...
March 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322146/chemical-composition-and-antioxidant-and-antibacterial-activities-of-cultured-mycelia-of-four-clavicipitaceous-mushrooms-ascomycetes-from-the-indian-himalayas
#6
Sapan Kumar Sharma, Nandini Gautam
Cultured mycelia of 4 clavicipitaceous fungi belonging to 2 genera, Cordyceps (C. gracilis, C. cicadae, C. sinclairii) and Metacordyceps (M. dhauladharensis), were analyzed for their chemical composition and antioxidant and antibacterial activities. Experiments to determine these characteristics were performed following standard methods. The fatty acid profiles of mycelia of all the species were analysed using gas chromatography. Chemical composition analysis of mycelial samples revealed carbohydrates (46.72 ± 0...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28318092/lycopene-and-risk-of-cardiovascular-diseases-a-meta-analysis-of-observational-studies
#7
Bo Song, Kai Liu, Yuan Gao, Lu Zhao, Hui Fang, Yusheng Li, Lulu Pei, Yuming Xu
SCOPE: The aim of current meta-analysis was to investigate the relation between lycopene and risk of cardiovascular diseases (CVD). METHODS AND RESULTS: Studies concerning about the association between lycopene and risk of CVD were searched on Pubmed, Embase, and Web of Science from inception to October 2016. A total of 14 eligible studies were identified. A significantly inverse association with a pooled risk ratio (RR) of 0.83 (95% CI: 0.76-0.90) was shown between lycopene exposure and risk of CVD...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317750/effects-of-storage-time-and-temperature-on-lipid-oxidation-of-egg-powders-enriched-with-natural-antioxidants
#8
Paula Toshimi Matumoto-Pintro, Alice Eiko Murakami, Ana Carolina Pelaes Vital, Camila Croge, Denise Felix da Silva, Ivan Camilo Ospina-Roja, Ana Flávia Quiles Garcia Guerra
The lipid fraction of egg powder may be affected by storage conditions due to the development of oxidative rancidity caused by polyunsaturated fatty acids. This study evaluated egg powders enriched with antioxidants [tocopherol, catechin, lycopene, and butylated hydroxyanisole (BHA)] for conjugated dienes (during a 90-day period) and for malonaldehydes (during a 210-day period) at 25±2 and 4±1°C. The presence of lycopene and BHA increases the total phenolic compounds in the enriched egg powders, and BHA exhibits the most antioxidant activity, as quantified by an ABTS assay...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317724/a-metabolomic-evaluation-of-the-phytochemical-composition-of-tomato-juices-being-used-in-human-clinical-trials
#9
Morgan J Cichon, Ken M Riedl, Steven J Schwartz
Juices from the traditional red tomato and a unique tangerine tomato variety are being investigated as health promoting foods in human clinical trials. However, it is unknown how the tangerine and red tomato juices differ in biologically relevant phytochemicals beyond carotenoids. Here liquid-chromatography high-resolution mass spectrometry metabolomics was used to evaluate broadly the similarities and differences in carotenoids and other phytochemicals between red and tangerine tomato juices intended for clinical interventions...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28301727/carotenoid-profile-antioxidant-capacity-and-chromoplasts-of-pink-guava-psidium-guajava-l-cv-%C3%A2-criolla%C3%A2-during-fruit-ripening
#10
Carolina Rojas-Garbanzo, Maike Gleichenhagen, Annerose Heller, Patricia Esquivel, Nadine Schulze-Kaysers, Andreas Schieber
Pigments of pericarp and pulp of pink guava (Psidium guajava L. cv. ´Criolla´) were investigated to elucidate the profile and the accumulation of main carotenoids during four stages of fruit ripening by using HPLC-DAD and APCI-MS/MS analysis. Seventeen carotenoids were identified and changes in their profile during fruit ripening were observed. The carotenoids all-trans-β-carotene, 15-cis-lycopene, and all-trans-lycopene were present in all ripening stages, but all-trans-lycopene was found to be predominant (from 63 % to 92 % of total carotenoids) and responsible for the high lipophilic antioxidant capacity determined by spectrophotometric assays...
March 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28293540/inverse-association-between-dietary-intake-of-selected-carotenoids-and-vitamin-c-and-risk-of-lung-cancer
#11
Martine Shareck, Marie-Claude Rousseau, Anita Koushik, Jack Siemiatycki, Marie-Elise Parent
While diets rich in fruit and vegetables appear to reduce lung cancer risk, the evidence for individual carotenoid and vitamin intakes has been judged too limited to reach firm conclusions. Data from a case-control study of lung cancer (Montreal, QC, Canada, 1996-2002) were used to investigate the role of dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lutein/zeaxanthin, lycopene, and vitamin C in lung cancer risk. In-person interviews elicited dietary information from 1,105 incident cases and 1,449 population controls...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28289912/production-of-%C3%AE-carotene-by-expressing-a-heterologous-multifunctional-carotene-synthase-in-yarrowia-lipolytica
#12
Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Yu Jiang, Daijie Chen, Sheng Yang
OBJECTIVES: To obtain functional expression of a heterologous multifunctional carotene synthase containing phytoene synthase, phytoene dehydrogenase, and lycopene β-cyclase activities encoded by carS from Schizochytrium sp. in order to allow Yarrowia lipolytica to produce β-carotene. RESULTS: To increase the integration efficiency of a 3.8 kb carS under the control of P GPD promoter with a 2 kb selection marker, ura3, along with a geranylgeranyl diphosphate synthase (GGS1) expression cassette (~10 kb in total), was inserted into the Y...
March 13, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28284159/portable-raman-spectroscopy-for-an-in-situ-monitoring-the-ripening-of-tomato-solanum-lycopersicum-fruits
#13
Josu Trebolazabala, Maite Maguregui, Héctor Morillas, Alberto de Diego, Juan Manuel Madariaga
Ripening is one of the most important transformations that fruits and vegetables suffer, from an unripe to a ripe stage. In this study, it was followed up and analyzed the variations in the composition of tomato fruits at different ripening stages (green or unripe, orange or middle ripe, red or ripe and brown or overripe). The results obtained from the Raman measurements carried out showed a change in the composition of tomato fruits in the transit from green to brown. The analysis confirmed an increase of carotenoids from an unripe to a ripe stage of these fruits, being lycopene the characteristic carotenoid of the optimum ripe stage...
March 7, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28275103/serum-folate-vitamin-b-12-vitamin-a-%C3%AE-tocopherol-%C3%AE-tocopherol-and-carotenoids-do-not-modify-associations-between-cadmium-exposure-and-leukocyte-telomere-length-in-the-general-us-adult-population
#14
Sarah Jo Nomura, Kim Robien, Ami R Zota
Background: Leukocyte telomere length (LTL) is a biomarker of the aging process and is associated with the risk of chronic disease. Higher exposure to cadmium may be associated with shorter LTL, and adequate nutrient concentrations may be associated with longer LTL; however, the potential interaction between metals and nutrients on LTL has yet to be examined.Objectives: The objective of this study was to evaluate whether serum concentrations of vitamins and carotenoids were associated with LTL, and whether they modified the association between blood cadmium and LTL in the US NHANES (1999-2002)...
March 8, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28270225/post-transcriptional-regulation-of-fruit-ripening-and-disease-resistance-in-tomato-by-the-vacuolar-protease-slvpe3
#15
Weihao Wang, Jianghua Cai, Peiwen Wang, Shiping Tian, Guozheng Qin
BACKGROUND: Proteases represent one of the most abundant classes of enzymes in eukaryotes and are known to play key roles in many biological processes in plants. However, little is known about their functions in fruit ripening and disease resistance, which are unique to flowering plants and required for seed maturation and dispersal. Elucidating the genetic mechanisms of fruit ripening and disease resistance is an important goal given the biological and dietary significance of fruit. RESULTS: Through expression profile analyses of genes encoding tomato (Solanum lycopersicum) cysteine proteases, we identify a number of genes whose expression increases during fruit ripening...
March 7, 2017: Genome Biology
https://www.readbyqxmd.com/read/28269786/dietary-lycopene-supplementation-improves-cognitive-performances-in-tau-transgenic-mice-expressing-p301l-mutation-via-inhibiting-oxidative-stress-and-tau-hyperphosphorylation
#16
Lixia Yu, Weiguang Wang, Wei Pang, Zhonghai Xiao, Yugang Jiang, Yan Hong
BACKGROUND: Oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD) and other tauopathies and participates in their development by promoting hyperphosphorylation of microtubule-associated protein tau. Lycopene, as an effective antioxidant, combined with vitamin E seemed to be additive against oxidative stress. OBJECTIVE: The present study was undertaken to examine whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28267248/lycopene-and-tomato-powder-supplementation-similarly-inhibit-high-fat-diet-induced-obesity-inflammatory-response-and-associated-metabolic-disorders
#17
Soumia Fenni, Habib Hammou, Julien Astier, Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Franck Tourniaire, Jean-François Landrier
SCOPE: Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity associated disorders. METHODS AND RESULTS: Male C57BL/J6 mice were assigned into 4 groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28250683/evaluation-of-oxidative-stress-in-chronic-periodontitis-patients-following-systemic-antioxidant-supplementation-a-clinical-and-biochemical-study
#18
Manasa Ambati, Koduganti Rekha Rani, Panthula Veerendranath Reddy, Jammula Suryaprasanna, Rajashree Dasari, Himabindu Gireddy
CONTEXT: Oxidative stress is associated with the pathogenesis of many systemic diseases including chronic periodontitis. Periodontal pathogen activated neutrophils liberate the reactive oxygen species (ROS), which causes the destruction of periodontal tissues. Antioxidants modulate the ROS production and inhibit the tissue destruction. AIM: We aimed to evaluate the oxidative stress marker malondialdehyde (MDA) in chronic periodontitis patients following scaling and root planing (SRP) after systemic lycopene supplementation...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28250599/evaluation-of-bioactive-compounds-and-antioxidant-potential-of-hydroethanolic-extract-of-moringa-oleifera-lam-from-rajasthan-india
#19
Sharad Vats, Tanya Gupta
Moringa oleifera Lam., the miracle tree, is widely used as a traditional medicine. The analyses of phytochemicals and antioxidant potential of hydroethanolic extract of various plant parts of M. oleifera revealed that leaves possessed the highest content of total phenolics (9.58 mg/g), β-carotene (14.10 mg/g) and lycopene (2.60 mg/g). Flowers and bark showed the highest content of total flavonoids (3.5 mg/g) and anthocyanin (52.80 mg/g), respectively. Leaves also showed maximum antioxidant potential using nitric oxide scavenging assay (IC50 - 120 µg/ml) and deoxyribose degradation assay (IC50-178 µg/ml)...
January 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/28250025/synthesis-of-apo-13-and-apo-15-lycopenoids-cleavage-products-of-lycopene-that-are-retinoic-acid-antagonists
#20
Sureshbabu Narayanasamy, Jian Sun, Ryan E Pavlovicz, Abdulkerim Eroglu, Cassandra E Rush, Benjamin D Sunkel, Chenglong Li, Earl H Harrison, Robert W Curley
Consumption of the tomato carotenoid, lycopene, has been associated with favorable health benefits. Some of lycopenes biological activity may be due to metabolites resulting from cleavage of the lycopene molecule. Because of their structural similarity to the retinoic acid receptor antagonist beta-apo-13-carotenone, the first half putative oxidative cleavage products of the symmetrical lycopene have been synthesized. All transformations proceed in moderate to good yield and some with high stereochemical integrity allowing ready access to these otherwise difficult to obtain terpenoids...
March 1, 2017: Journal of Lipid Research
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