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Dedong Min, Fujun Li, Xinhua Zhang, Xixi Cui, Pan Shu, Lulu Dong, Chuntao Ren
MYC2, a basic helix-loop-helix transcription factor, is a master regulator in Jasmonic acid (JA) signaling pathway. However, the functions of SlMYC2 in MeJA-mediated fruit chilling tolerance are far from being clearly understood. Thus, in present work, we constructed SlMYC2-silenced tomato fruit by virus-induced gene silencing (VIGS) and investigated the function of SlMYC2 in MeJA-induced tomato fruit chilling tolerance. The results showed that MeJA treatment markedly induced the SlMYC2 expression, increased proline content, lycopene content and antioxidant enzyme activities, including superoxide dismutase, peroxidase, catalase and ascorbate peroxidase, inhibited the increase of electrical conductivity and malondialdehyde content, and effectively reduced the chilling injury (CI) incidence and CI index...
March 12, 2018: Journal of Agricultural and Food Chemistry
Juan Guillermo Cataño, Carlos Gustavo Trujillo, Juan Ignacio Caicedo, Alejandra Bravo-Balado, Daniela Robledo, Angela Marcela Mariño-Alvarez, Adriana Pedraza, María Juliana Arcila, Mauricio Plata
OBJECTIVE: To evaluate the efficacy of lycopene intake in primary prevention of prostate cancer (PCa). METHODS: A systematic search of the literature was conducted in March 2015 and the articles published between the years 1990-2015 were reviewed. The following search terms were used: prostate cancer, prostatic neoplasm, lycopene, prevention, effectiveness and efficacy (MeSH). Publications including research in humans, written in English and whose texts were accessible were reviewed...
March 2018: Archivos Españoles de Urología
Rajkumar U Zunjare, Firoz Hossain, Vignesh Muthusamy, Aanchal Baveja, Hema S Chauhan, Jayant S Bhat, Nepolean Thirunavukkarasu, Supradip Saha, Hari S Gupta
Traditional yellow maize though contains high kernel carotenoids, the concentration of provitamin A (proA) is quite low (<2 μg/g), compared to recommended level (15 μg/g). It also possesses poor endosperm protein quality due to low concentration of lysine and tryptophan. Natural variant of crtRB1 (β -carotene hydroxylase ) and lcyE ( lycopene- ε -cyclase ) cause significant enhancement of proA concentration, while recessive allele, opaque2 ( o2 ) enhances the level of these amino acids. Development of biofortified maize enriched in proA, lysine and tryptophan thus holds significance in alleviation of micronutrient malnutrition...
2018: Frontiers in Plant Science
Beita Zhao, Hua Liu, Jiamin Wang, Pujie Liu, Xintong Tan, Bo Ren, Zhigang Liu, Xuebo Liu
Carotenoid pigment lycopene (LYC) possesses several types of properties such as antioxidative, anti-inflammatory, and neuroprotective. This study examined the effects of dietary supplementation with LYC on age-induced cognitive impairment, and the potential underlying mechanisms. Behavioral tests revealed that chronic LYC supplementation alleviated age-associated memory loss and cognitive defects. Histological and immunofluorescence staining results indicated that LYC treatment reversed age-associated neuronal damage and synaptic dysfunction in the brain...
March 6, 2018: Journal of Agricultural and Food Chemistry
Cheng Wang, Rui Qiu, Yi Cao, Wei-Fu Ouyang, Hua-Bin Li, Wen-Hua Ling, Yu-Ming Chen
Several studies have suggested that higher carotenoid levels may be beneficial for atherosclerosis patients, but few studies have examined this relationship in the Chinese population. This cross-sectional study examined the association between the levels of carotenoids in diet and serum and carotid intima-media thickness (IMT) in Chinese adults aged 50-75 years in Guangzhou, China. Dietary intake was assessed using a FFQ. HPLC was used to assay the serum concentrations of α-carotene, β-carotene, lutein+zeaxanthin, β-cryptoxanthin and lycopene...
March 2018: British Journal of Nutrition
Angela Perucatti, Viviana Genualdo, Alfredo Pauciullo, Ciro Iorio, Domenico Incarnato, Cristina Rossetti, Francesco Vizzarri, Marisa Palazzo, Donato Casamassima, Leopoldo Iannuzzi, Alessandra Iannuzzi
Phenylpropanoid glycosides (PPG), like other phenolic compounds, are a powerful antioxidants and the Verbascoside (VB) is one of the most active of them. A previous study, by using in vitro exposure of blood human lymphocytes to Verbascoside, reported a significant increasings of chromosome fragility compared to control. In the present study, four homogeneous groups of rabbits were used to test in vivo the VB and/or Lycopene (LP) by feeding the animals without VB and LP (control), in presence of VB or/and LP for 80 days...
February 26, 2018: Food and Chemical Toxicology
Raúl Martí, Mercedes Valcárcel, Miguel Leiva-Brondo, Inmaculada Lahoz, Carlos Campillo, Salvador Roselló, Jaime Cebolla-Cornejo
The effect of controlled deficit irrigation (CDI) on the accumulation of carotenoids, polyphenols and l-ascorbic acid was studied in conventional and high lycopene tomato cultivars. Plants were initially irrigated to cover 100%ETc and after the fruit set phase, the dose was reduced to 75% or 50% of ETc . CDI had no significant effect on the accumulation of carotenoids, while it increased the levels of the hydroxycinnamic acids chlorogenic and ferulic acids, the flavonoid rutin and l-ascorbic acid. Nevertheless, there were important interactions and this effect was highly dependent on the year and site of cultivation...
June 30, 2018: Food Chemistry
Akifumi Kawata, Yukio Murakami, Seiji Suzuki, Seiichiro Fujisawa
BACKGROUND/AIM: The polyene carotenoids β-carotene and lycopene are antioxidants that not only quench singlet oxygen but also inhibit lipid peroxidation. Tri-n-butyl borane (TBB) is used as an initiator for dental resin materials and is extremely reactive with oxygen and reactive oxygen species (ROS). This reactionability of TBB may be analogous to that of carotenoids with ROS. To clarify the biological activity of such ROS scavengers, we investigated the anti-inflammatory activity of β-carotene, lycopene and TBB in terms of the expression of RNA for lipopolysaccharide (LPS)-induced cyclooxygenase-2 (Cox2), nitric oxide synthase 2 (Nos2) and tumor necrosis factor-alpha (Tnfa), and mRNA expression and up-regulation of heme oxygenase 1 (Hmox1) mRNA in RAW264...
March 2018: In Vivo
Jianling Zhang, Zongli Hu, Qiyuan Yao, Xuhu Guo, Vanluc Nguyen, Fenfen Li, Guoping Chen
The MADS-box transcription factors play essential roles in many physiological and biochemical processes of plants, especially in fruit ripening. Here, a tomato MADS-box gene, SlCMB1, was isolated. SlCMB1 expression declined with the fruit ripening from immature green to B + 7 (7 days after Breaker) fruits in the wild type (WT) and was lower in Nr and rin mutants fruits. Tomato plants with reduced SlCMB1 mRNA displayed delayed fruit ripening, reduced ethylene production and carotenoid accumulation. The ethylene production in SlCMB1-RNAi fruits decreased by approximately 50% as compared to WT...
February 21, 2018: Scientific Reports
Su Wen Lu, Yin Zhang, Kaijie Zhu, Wei Yang, Jun Li Ye, Lijun Chai, Qiang Xu, Xiuxin Deng
Although remarkable progress has been made towards understanding carotenoid biosynthesis, the mechanisms that regulate the transcription of carotenogenic genes remain poorly understood. Lycopene β-cyclases (LCYb) are critical enzymes located at the branch point of the carotenoid biosynthetic pathway. Here, we used the promoter sequence of LCYb1 as bait in a yeast one-hybrid screen for promoter-binding proteins from sweet orange (Citrus sinensis). This screen identified a MADS transcription factor, CsMADS6, that was coordinately expressed with fruit development and coloration...
February 20, 2018: Plant Physiology
Junrui Cheng, Benchun Miao, Kang-Quan Hu, Xueyan Fu, Xiang-Dong Wang
SCOPE: We have previously shown that apo-10'-lycopenoic acid (ALA), a derivative of lycopene through cleavage by carotene-9',10'-oxygenase, inhibits tumor progression and metastasis in both liver and lung cancer animal models. The underlying mechanism remains unknown. We hypothesized that ALA inhibits cancer cell motility and angiogenesis by up-regulating peroxisome proliferator-activated receptor γ (PPARγ) which is involved in controlling angiogenesis, tumor progression and metastasis...
January 31, 2018: Journal of Nutritional Biochemistry
Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu, Xuebo Liu
Neuroinflammation is documented to be the major culprit of Alzheimer's disease. Lycopene (LYC), a fat soluble carotenoid, exhibits neuroprotective function in several neurodegenerative disorders. However, the effects of LYC to countering systemic inflammation-induced amyloidogenesis and memory deficiency remain to be elucidated. In current study, 3-month-old male C57BL/6J mice were treated with 0.03% LYC (w/w, mixed into normal chow) for 5 weeks. The mice were then treated by intraperitoneal injection of LPS (0...
February 2, 2018: Journal of Nutritional Biochemistry
Sylvin Benjamin Ateba, Sadrine Tchoukouegno Ngeu, Marie Alfrede Mvondo, Job Tchoumtchoua, Charline Florence Awounfack, Liselotte Krenn, Dieudonne Njamen
BACKGROUND: The approval of Taxol® in 1993 marked the great entrance of terpenoids in the anti-cancer area and this drug is still highly important in the treatment of refractory ovarian, breast and other cancers. Over decades, other prominent natural terpenoids have become indispensable for the modern pharmacotherapy of breast cancer. However, given the rapid evolution of drug resistance, effective treatments for advanced breast cancers requiring cytotoxic chemotherapy represent a major unmet clinical need...
February 13, 2018: Current Medicinal Chemistry
Ran Li, Daqi Fu, Benzhong Zhu, Yunbo Luo, Hongliang Zhu
With the development of high throughput sequencing, plenty of long non-coding RNAs (lncRNAs) have been discovered to play important roles in diverse biological processes. However, the biological functions of most plant lncRNAs are still unknown. Previously, we had discovered a tomato ripening-related lncRNA, lncRNA1459. Here, we cloned the full-length lncRNA1459, which obtained two transcript isoforms. In addition, lncRNA1459 exhibited specific location in the nucleus. Furthermore, in order to fully identify the function of lncRNA1459 in tomato ripening, loss-function mutants of lncRNA1459 were developed using clusterd regularly interspaced short palindromic repeats (CRISPR)/-associated protein 9 (Cas9)-induced genome editing technology...
February 15, 2018: Plant Journal: for Cell and Molecular Biology
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Omnia B Hamada
BACKGROUND: Oxidative stress and inflammation may play a key role in the pathogenesis of acute pancreatitis (AP). Lycopene, a natural carotenoid, has antioxidant scavenger capacity and inhibits inflammation in many experimental models. AIM: The study was designed to investigate whether lycopene can ameliorate l-arginine-induced pancreatitis in rats and to elucidate the underlying molecular mechanisms of these effects. METHODS: Forty-eight adult male Wistar rats were divided into: control group (vehicle, orally, 10 days), AP group (3 g/kg l-arginine, single i...
February 2, 2018: Digestive and Liver Disease
Kathryn Mullan, Chris R Cardwell, Bernadette McGuinness, Jayne V Woodside, Gareth J McKay
Serum antioxidants may afford neuroprotection against Alzheimer's disease (AD) via correction of the pro-oxidative imbalance but findings reported have been inconsistent. We compared the pooled mean difference in serum levels of ten dietary antioxidants between patients with AD and cognitively intact controls from 52 studies in meta-analyses using random-effects models. Patients with AD had significantly lower plasma levels of α-carotene, β-carotene, lycopene, lutein, vitamin A, C, and E, and uric acid. No significant difference was observed for plasma levels of β-cryptoxanthin and zeaxanthin...
2018: Journal of Alzheimer's Disease: JAD
Corrine Hanson, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Kimberly White, Nina Overby, Ann Anderson-Berry
Oxidative stress has been associated with adverse neonatal outcomes, and many carotenoids, including lycopene, potentially have antioxidant properties. The objective of this analysis was to explore the associations between serum lycopene concentrations, including lycopene isomers, and maternal-newborn outcomes. Maternal and cord blood samples were collected in 180 mother-infant pairs. Serum of total lycopene as well as the cis - and trans -isomers concentrations were measured using HPLC (High Performance Liquid Chromatography)...
February 13, 2018: Nutrients
Latifeh Ahmadi, Xiuming Hao, Rong Tsao
BACKGROUND: The effect of light transmission (direct and diffuse) on the phenolic compounds of five tomato cultivars was investigated under controlled conditions in greenhouses covered with different covering materials. RESULTS: The type of covering materials and type of diffusion of light simultaneously affected the reducing power of cultivars. In the present study, a two-way analysis of variance showed statistically significant differences in total phenolic compound (TPC) for the different cultivars (P<0...
February 13, 2018: Journal of the Science of Food and Agriculture
Raimunda C Dos Santos, Alicia S Ombredane, Jéssica Maria T Souza, Andreanne G Vasconcelos, Alexandra Plácido, Adriany das G N Amorim, Eder Alves Barbosa, Filipe C D A Lima, Cristina D Ropke, Michel M M Alves, Daniel D R Arcanjo, Fernando A A Carvalho, Cristina Delerue-Matos, Graziella A Joanitti, José Roberto de S A Leite
This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. The cytotoxic activity of LEG and the underlying mechanism was studied in human breast adenocarcinoma cells (MCF-7), murine fibroblast cells (NIH-3T3), BALB/c murine peritoneal macrophages, and sheep blood erythrocytes by evaluating the cell viability with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and flow cytometry...
March 2018: Food Research International
Kazuya Murakami, Masaki Honda, Ryota Takemura, Tetsuya Fukaya, Wahyudiono, Hideki Kanda, Motonobu Goto
The stability of lycopene with high Z-isomers content during thermal treatment and light irradiation was investigated. Purified (all-E)-lycopene was thermally isomerized to the Z-isomers in dichloromethane (CH2Cl2) at 50 °C for 24 h. The total content of the Z-isomers of lycopene reached 56.1%. Then, the mixture of lycopene isomers was stored in the dark at 4, 25, and 40 °C for 30 days, and under light irradiation using a fluorescent light at 4 °C for 336 h. The degradation rate of lycopene during thermal treatment rose with increasing temperature and the activation energy for decomposition of the mixture of lycopene isomers was calculated to be 71...
June 1, 2018: Food Chemistry
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