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garcinia cambogia

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https://www.readbyqxmd.com/read/29328461/anti%C3%A2-inflammatory-effects-of-gambogic-acid-in-murine-collagen%C3%A2-induced-arthritis-through-pi3k-akt-signaling-pathway
#1
Qing Lai Wang, Dong Zhen Yang, Cunxian Lv
Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It was demonstrated that gambogic acid decreased arthritic scores in murine collagen‑induced arthritic mice...
January 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29317394/garcinia-cambogia-for-weight-loss
#2
Stacy L Haber, Omar Awwad, April Phillips, Andrew E Park, Tam Minh Pham
No abstract text is available yet for this article.
January 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29298511/chrysanthemum-indicum-inhibits-adipogenesis-and-activates-the-ampk-pathway-in-high-fat-diet-induced-obese-mice
#3
Sarmila Nepali, Ji-Yun Cha, Hyeon-Hui Ki, Hoon-Yeon Lee, Young-Ho Kim, Dae-Ki Kim, Bong-Joon Song, Young-Mi Lee
Chrysanthemum indicum (CI) is widely distributed in China and many parts of the tropical world, and has been reported to have antibacterial, antiviral, anti-oxidant and immunomodulatory effects, but no information is available on its effects on high fat diet (HFD)-induced obesity. This was undertaken to investigate the mechanism responsible for the effect of ethyl acetate fraction of CI (CIEA) on adipogenesis, in vitro and in vivo models of obesity. In the in vitro study, differentiating 3T3-L1 cells were treated with media to initiate differentiation (MDI) in the presence or absence of CIEA with different concentrations, and in the in vivo study, C57BL/6 mice were fed with HFD and administered CIEA daily for six weeks...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29290737/abuse-and-misuse-of-selected-dietary-supplements-among-adolescents-a-look-at-poison-center-data
#4
Jessica M Biggs, Jill A Morgan, Allison B Lardieri, Omayma A Kishk, Wendy Klein-Schwartz
OBJECTIVE: The use of dietary supplements has increased and is associated with adverse effects. Indications for use include recreation, body image concerns, mood enhancement, or control of medical conditions. The risk of adverse effects may be enhanced if agents are used improperly. The objective of this study was to determine the frequency of abuse and misuse of 4 dietary substances among adolescents reported nationally to poison centers. Secondary outcomes included an assessment of medical outcomes, clinical effects, location of treatments provided, and treatments administered...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29241577/caulerpa-okamurae-extract-inhibits-adipogenesis-in-3t3-l1-adipocytes-and-prevents-high-fat-diet-induced-obesity-in-c57bl-6-mice
#5
Bhesh Raj Sharma, Hyun Jung Kim, Min Suk Kim, Chul Min Park, Dong Young Rhyu
Seaweeds are considered a potential source of antiobesity agents. Because Caulerpa, a seaweed, has been consumed for food in Japan, China, South Korea, and Australia, we hypothesized that Caulerpa okamurae may have antiobesity effects in an animal model of high-fat diet (HFD)-induced obesity in C57BL/6 mice. Herein, we found that the ethanolic extract of C okamurae (COE) significantly inhibited lipid accumulation and reduced the expression of the master regulator of adipogenesis, peroxisome proliferator-activated receptor-γ, sterol regulatory element binding protein-1c, and CCAAT/enhancer-binding protein-α in 3T3-L1 adipocytes...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29207025/anti-obesity-effects-of-pectinase-and-cellulase-enzyme%C3%A2-treated-ecklonia%C3%A2-cava-extract-in-high%C3%A2-fat-diet%C3%A2-fed-c57bl-6n-mice
#6
In-Hye Kim, Jung-Wook Choi, Min-Kyeong Lee, Chang-Ju Kwon, Taek-Jeong Nam
The present study investigated the anti‑obesity effects of enzyme‑treated Ecklonia cava extract (EEc) in C57BL/6N mice with high‑fat diet (HFD)‑induced obesity. The EEc was separated and purified with the digestive enzymes pectinase (Rapidase X‑Press L) and cellulase (Rohament CL) and its effects on the progression of HFD‑induced obesity were examined over 10 weeks. The mice were divided into 6 groups (n=10/group) as follows: Normal diet group, HFD group, mice fed a HFD with 25 mg/kg/day Garcinia cambogia extract and mice fed a HFD with 5, 25 or 150 mg/kg/day EEc (EHD groups)...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28982303/possible-garcinia-cambogia-induced-mania-with-psychosis-a-case-report
#7
David C Nguyen, Tysen K Timmer, Blair C Davison, Ian R McGrane
Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox™ dietary supplement manufactured by Apex Vitality Health...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28968624/garcinia-cambogia-diabetic-ketoacidosis-and-pancreatitis
#8
Tamara Bystrak, Miguel E Cervera-Hernandez, Nishitha Reddy, Zachary King, Jeffrey Bratberg
[Full article available at http://rimed.org/rimedicaljournal-2017-10.asp].
October 2, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28877777/metabolomics-reveals-the-mechanism-of-hydroxycitric-acid-promotion-of-protein-synthesis-and-inhibition-of-fatty-acid-synthesis-in-broiler-chickens
#9
M L Peng, J Han, L L Li, H T Ma
(-)-Hydroxycitric acid (HCA), a major component of Garcinia cambogia extracts, has been shown to suppress BW gain and fat accumulation in animals and humans. However, the mechanism remains unknown. In this study, gas chromatography-mass spectrometry was used to analyse serum metabolites, and principal component analysis and partial least-squares-discriminant analysis models were generated to analyse serum metabolite changes in broiler chickens after the administration of (-)-HCA at 0, 1000, 2000 and 3000 mg/kg diets for 28 days...
September 7, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28777081/binding-of-hydroxycitrate-to-human-atp-citrate-lyase
#10
Jinhong Hu, Aruna Komakula, Marie E Fraser
Hydroxycitrate from the fruit of Garcinia cambogia [i.e. (2S,3S)-2-hydroxycitrate] is the best-known inhibitor of ATP-citrate lyase. Well diffracting crystals showing how the inhibitor binds to human ATP-citrate lyase were grown by modifying the protein. The protein was modified by introducing cleavage sites for Tobacco etch virus protease on either side of a disordered linker. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen...
August 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28350055/enzyme-treated-ecklonia-cava-extract-inhibits-adipogenesis-through-the-downregulation-of-c-ebp%C3%AE-in-3t3-l1-adipocytes
#11
In-Hye Kim, Taek-Jeong Nam
In this study, we examined the inhibitory effects of enzyme- treated Ecklonia cava (EEc) extract on the adipogenesis of 3T3-L1 adipocytes. The components of Ecklonia cava (E. cava) were first separated and purified using the digestive enzymes pectinase (Rapidase® X‑Press L) and cellulase (Rohament® CL). We found that the EEc extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-A. Among the phlorotannins, dieckol was the most abundant in the EEc extract at 16 mg/g. Then we examined the inhibitory effects of EEc extract treatment on differentiation‑related transcription factors and on adipogenesis‑related gene expression in vitro using 3T3-L1 adipocytes...
January 26, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28326002/anti-obesity-effect-of-solidago-virgaurea-var-gigantea-extract-through-regulation-of-adipogenesis-and-lipogenesis-pathways-in-high-fat-diet-induced-obese-mice-c57bl-6n
#12
Zhiqiang Wang, Ju Hee Kim, Young Soo Jang, Chea Ha Kim, Jae-Yong Lee, Soon Sung Lim
Background: Obesity is associated with an increase in adipogenesis and is becoming a serious health problem in modern society. Objective: The effects of various Solidago virgaurea var. gigantean (SV) ethanolic aqueous extracts on anti-adipogenesis in 3T3-L1 cells were investigated. In addition, the effect of SV 10% ethanolic extract (SV10E) on preventing obesity was studied in high-fat diet-induced obese mice (C57BL/6 N). Design: The effect of SV10E on preventing obesity was studied in mice (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia cambogia extract of 60% (-)-hydroxycitric acid (positive control), HFD supplemented with 0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28288493/inhibitory-effects-of-garcinia-cambogia-extract-on-cyp2b6-enzyme-activity
#13
Jun Sang Yu, Min Sun Choi, Jong Suk Park, Shaheed Ur Rehman, Katsunori Nakamura, Hye Hyun Yoo
This study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner...
July 2017: Planta Medica
https://www.readbyqxmd.com/read/28271601/phytochemical-compounds-in-sport-nutrition-synephrine-and-hydroxycitric-acid-hca-as-examples-for-evaluation-of-possible-health-risks
#14
REVIEW
Nadiya Bakhiya, Rainer Ziegenhagen, Karen I Hirsch-Ernst, Birgit Dusemund, Klaus Richter, Katharina Schultrich, Sophie Pevny, Bernd Schäfer, Alfonso Lampen
Numerous food supplements contain phytochemical compounds as active ingredients. Although such supplements are often perceived by consumers as being risk-free, the safety of many of them is currently uncertain. The present review provides two examples for risk assessment for phytochemical ingredients that are used in certain supplements marketed for sportspeople-synephrine (extracted from fruits of Citrus aurantium) and hydroxycitric acid (HCA, isolated from fruits of Garcinia cambogia). Animal and human studies, as well as case reports, provide evidence for cardiovascular effects due to ingestion of high synephrine doses, especially in combination with caffeine and physical exertion...
June 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28204815/enzyme-treated-ecklonia-cava-extract-inhibits-adipogenesis-through-the-downregulation-of-c-ebp%C3%AE-in-3t3-l1-adipocytes
#15
In-Hye Kim, Taek-Jeong Nam
In this study, we examined the inhibitory effects of enzyme- treated Ecklonia cava (EEc) extract on the adipogenesis of 3T3-L1 adipocytes. The components of Ecklonia cava (E. cava) were first separated and purified using the digestive enzymes pectinase (Rapidase® X‑Press L) and cellulase (Rohament® CL). We found that the EEc extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-A. Among the phlorotannins, dieckol was the most abundant in the EEc extract at 16 mg/g. Then we examined the inhibitory effects of EEc extract treatment on differentiation‑related transcription factors and on adipogenesis‑related gene expression in vitro using 3T3-L1 adipocytes...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28098516/germacrone-attenuates-hyperlipidemia-and-improves-lipid-metabolism-in-high-fat-diet-induced-obese-c57bl-6j-mice
#16
Yuan-Ri Guo, Se-Young Choung
We previously showed that Aster spathulifolius Maxim extract (ASE) reduced body weight gain and serum and liver lipid levels and significantly suppressed serum insulin and leptin concentrations in high-fat diet (HFD)-induced obese rats. Germacrone (GM) was identified as a potent bioactive constituent of ASE. In this study, we hypothesized that GM can attenuate hyperlipidemia by alleviating fatty acid (FA) synthesis/uptake and improve lipid metabolism by stimulating FA β-oxidation in HFD-induced obese C57BL/6J mice...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28018115/dangerous-dietary-supplements-garcinia-cambogia-associated-hepatic-failure-requiring-transplantation
#17
Keri E Lunsford, Adam S Bodzin, Diego C Reino, Hanlin L Wang, Ronald W Busuttil
Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27757272/effect-of-orlistat-alone-or-in-combination-with-garcinia-cambogia-on-visceral-adiposity-index-in-obese-patients
#18
Hayder M Al-Kuraishy, Ali I Al-Gareeb
AIM: The objective of this study was to estimate the effect of orlistat alone and in combination with Garcinia cambogia on visceral adiposity index (VAI) in obese patients. PATIENTS AND METHODS: A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated with G. cambogia 166 mg/day, and third group treated with orlistat 120 mg/day plus G...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27702395/identification-and-quantification-of-adulteration-in-garcinia-cambogia-commercial-products-by-chromatographic-and-spectrometric-methods
#19
Nargis Jamila, Ji Yeon Choi, Joon Ho Hong, Eun Yeong Nho, Naeem Khan, Cheon Ho Jo, Hyang Sook Chun, Kyong Su Kim
Species of genus Garcinia are rich sources of bioactive constituents with antimicrobial, anticancer, anti-inflammatory, hepatoprotective and anti-HIV activities. Commercial products of Garcinia cambogia are used as anti-obesity drugs with increasing market demand. Because of the high price of its products, it can be adulterated with similar lower-priced species. This study was designed to develop and validate an accurate and efficient method for the detection of any adulteration (G. indica) in G. cambogia products...
December 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27658722/gut-microbiota-modulated-by-probiotics-and-garcinia-cambogia-extract-correlate-with-weight-gain-and-adipocyte-sizes-in-high-fat-fed-mice
#20
Jaeyoung Heo, Minseok Seo, Hwanhee Park, Woon Kyu Lee, Le Luo Guan, Joon Yoon, Kelsey Caetano-Anolles, Hyeonju Ahn, Se-Young Kim, Yoon-Mo Kang, Seoae Cho, Heebal Kim
Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed...
2016: Scientific Reports
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