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Hervé Colinet, David Renault
Homeostenosis (i.e. decline in stress resistance and resilience with age) is a fundamental notion of the biogerontology and physiology of aging. Stressful situations typically challenge metabolic homeostasis and the capacity to recover from a stress-induced metabolic disorder might be particularly compromised in senescent individuals. In the present work, we report the effects of aging on low temperature stress tolerance and metabolic profiles in Drosophila melanogaster females of different ages. Adult flies aged 4, 16, 30 and 44days were subjected to acute and chronic cold stress, and data confirmed a strong decline in cold tolerance and resilience of old flies compared to young counterparts...
February 2018: Experimental Gerontology
Sadiya S Khan, Benjamin D Singer, Douglas E Vaughan
Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular, cellular, organ, and organismal level with genetic, epigenetic, and environmental modulators. Individuals with the same chronological age exhibit differential trajectories of age-related decline, and it follows that we should assess biological age distinctly from chronological age...
August 2017: Aging Cell
Kenn M Kirksey, Gayle McGlory, Elizabeth F Sefcik
Older adults comprise approximately 50% of patients admitted to critical care units in the United States. This population is particularly susceptible to multiple morbidities that can be exacerbated by confounding factors like age-related safety risks, polypharmacy, poor nutrition, and social isolation. The elderly are particularly vulnerable to health conditions (heart disease, stroke, and diabetes) that put them at greater risk of morbidity and mortality. When an older adult presents to the emergency department with 1 or more of these life-altering diagnoses, an admission to the intensive care unit is often inevitable...
July 2015: Critical Care Nursing Quarterly
Joseph Shega, William Dale, Judith Paice, Kenneth Rockwood, Debra Weiner
No abstract text is available yet for this article.
January 2011: Journal of Pain and Symptom Management
Jacek M Witkowski
In this paper the concept of homeostenosis (progressive reduction of ability to adapt producing loss of effectiveness) of the immune system is presented as a cause of the system ageing. In particular, the progression of immune system homeostenosis was shown to be associated with previous or ongoing chronic inflammatory diseases, including rheumatoid arthritis, type 2 diabetes, chronic kidney disease and Alzheimer's disease.
2014: Postepy Biochemii
Riccardo Calvani, Elisa Brasili, Giulia Praticò, Giorgio Capuani, Alberta Tomassini, Federico Marini, Fabio Sciubba, Alberto Finamore, Marianna Roselli, Emanuele Marzetti, Alfredo Miccheli
BACKGROUND: Aging is characterized by derangements in multiple metabolic pathways that progressively constrict the homeostatic reserve (homeostenosis). The signature of metabolic alterations that accompany aging can be retrieved through the metabolomic profiling of biological fluids. OBJECTIVE: To characterize the age-related changes in urinary and fecal metabolic profiles of BALB/c mice through a (1)H nuclear magnetic resonance (NMR)-based metabolomic approach...
January 2014: Experimental Gerontology
Robert L Kane, Tatyana Shamliyan, Kristine Talley, James Pacala
OBJECTIVES: To ascertain the effect on survival of eight common geriatric syndromes (multiple comorbidities, cognitive impairment, frailty, disability, sarcopenia, malnutrition, homeostenosis, and chronic inflammation), identified by an expert panel of academic geriatricians. DESIGN: A systematic literature review sought studies from a variety of sources to compare survival and life expectancy of individuals with geriatric syndromes with those of the general population...
May 2012: Journal of the American Geriatrics Society
Joseph W Shega, William Dale, Melissa Andrew, Judith Paice, Kenneth Rockwood, Debra K Weiner
OBJECTIVES: To compare the association between self-reported moderate to severe pain and frailty. DESIGN: Cross-sectional analysis of the Canadian Study of Health and Aging Wave 2. SETTING: Community. PARTICIPANTS: Representative sample of persons aged 65 and older in Canada. MEASUREMENTS: Pain (exposure) was categorized as no or very mild pain versus moderate or greater pain. Frailty (outcome) was operationalized as the accumulation of 33 possible self-reported health attitudes, illnesses, and functional abilities, subsequently divided into tertiles (not frail, prefrail, and frail)...
January 2012: Journal of the American Geriatrics Society
Giacomo Zoppini, Giuseppe Verlato, Giovanni Targher, Enzo Bonora, Maddalena Trombetta, Michele Muggeo
BACKGROUND: Ageing is characterized by a decreased functional reserve, a concept defined as homeostenosis. We assessed the impact of long-term exposure to the average value (mean) or to the variability (coefficient of variation) of fasting glycaemia, body mass index (BMI) and pulse pressure on total mortality in a cohort of type 2 diabetic patients. METHODS: Fasting glycaemia, BMI and pulse pressure values were collected over a period of 3 years in 1 319 type 2 diabetic patients who were subsequently followed up for 10 years...
November 2008: Diabetes/metabolism Research and Reviews
J F Karp, J W Shega, N E Morone, D K Weiner
Older adults with persistent pain are not simply a chronologically older version of younger pain patients. Pain-related disability in older adults may be driven by pain 'homeostenosis', that is, diminished ability to effectively respond to the stress of persistent pain. Some of the comorbidities of ageing that can contribute to pain homeostenosis include cognitive and physical impairments, increased sensitivity to suprathreshold pain stimuli, medical and psychological comorbidities, altered pharmacokinetics and pharmacodynamics, and social isolation...
July 2008: British Journal of Anaesthesia
James Lund, Patricia Tedesco, Kyle Duke, John Wang, Stuart K Kim, Thomas E Johnson
BACKGROUND: Numerous gerontogene mutants leading to dramatic life extensions have been identified in the nematode Caenorhabditis elegans over the last 20 years. Analysis of these mutants has provided a basis for understanding the mechanisms driving the aging process(es). Several distinct mechanisms including an altered rate of aging, increased resistance to stress, decreased metabolic rate, or alterations in a program causing organismic aging and death have been proposed to underlie these mutants...
September 17, 2002: Current Biology: CB
J A Troncale
Age-related physiologic changes are important to consider when making diagnostic and therapeutic decisions. Such changes begin in the fifth decade and continue at varying rates depending on the organ system involved. Physicians need to be aware of the ramifications of the aging process, especially with regard to decreased functional reserve and changes in drug actions. The concept of homeostenosis implies that a functional elderly person may maintain health into old age but become increasingly vulnerable to stress and illness because of a lack of physiologic reserve...
May 1996: Postgraduate Medicine
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