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https://www.readbyqxmd.com/read/28446006/trending-speculations-of-tumor-initiating-cells-in-squamous-cell-cancers-of-head-and-neck
#1
REVIEW
Wasim Kamate, Rajendra Baad, Nupura Vibhute, Uzma Belgaumi, Vidya Kadashetti, Sushma Gugwad
Tumor-initiating cells are a diminutive subpopulation of stem cells that have ability of long term self-renewal and generation of varied traits of tumor cell population. Understanding the concept of tumor-initiating cells may have a great implicative intimation for our comprehension of cancer pathobiology and for the delineation of new therapies directed towards these stem cells. The present review is an endeavor to conceptualize the role of tumor-initiating cells in the Squamous Cell Cancers (SCC) of head and neck, their role in tumorigenesis and the possible supplementary approach in the latest treatment modalities...
April 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28445942/mmp-3-and-mmp-8-single-nucleotide-polymorphisms-are-related-to-alcohol-induced-osteonecrosis-of-the-femoral-head-in-chinese-males
#2
Junyu Chen, Wanlin Liu, Yuju Cao, Xiyang Zhang, Yongchang Guo, Yong Zhu, Jian Li, Jieli Du, Tianbo Jin, Guoqiang Wang, Jianzhong Wang
Our study investigated the association between MMP-3 and MMP-8 single-nucleotide polymorphisms (SNPs) and alcohol-induced osteonecrosis of the femoral head (ONFH) in 695 Chinese males (299 cases and 396 control subjects). The minor allele of MMP-3 rs650108 was associated with a 0.78-fold decrease in alcohol-induced ONFH risk in the allelic model (95% CI = 0.63-0.97, P = 0.026). In the genetic model adjusted for age, rs650108 was associated with decreased risk of alcohol-induced ONFH in the dominant model (OR = 0...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445763/myosin-rod-hypophosphorylation-and-cb-kinetics-in-papillary-muscles-from-a-tnc-a8v-ki-mouse-model
#3
Masataka Kawai, Jamie R Johnston, Tarek Karam, Li Wang, Rakesh K Singh, Jose R Pinto
The cardiac troponin C (TnC)-A8V mutation is associated with hypertrophic and restrictive cardiomyopathy (HCM and RCM) in human and mice. The residue affected lies in the N-helix, a region known to affect Ca(2+)-binding affinity to the N-terminal domain. Here we report on the functional effects of this mutation in skinned papillary muscle fibers from homozygous knock-in TnC-A8V mice. Muscle fibers from left ventricle were activated at 25°C under the ionic conditions of working cardiomyocytes. The pCa-tension relationship showed a 3× increase in Ca(2+)-sensitivity and a decrease (0...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445747/physical-and-functional-characterization-of-a-viral-genome-maturation-complex
#4
Teng-Chieh Yang, David Ortiz, Qin Yang, Rolando W De Angelis, Saurarshi J Sanyal, Carlos E Catalano
Genome packaging is strongly conserved in the complex double-stranded DNA viruses, including the herpesviruses and many bacteriophages. In these cases, viral DNA is packaged into a procapsid shell by a terminase enzyme. The packaging substrate is typically a concatemer composed of multiple genomes linked in a head-to-tail fashion, and terminase enzymes perform two essential functions: 1) excision of a unit length genome from the concatemer (genome maturation) and 2) translocation of the duplex into a procapsid (genome packaging)...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445596/effectiveness-safety-and-acceptability-of-non-physician-provision-of-first-trimester-medical-termination-of-pregnancy-a-systematic-review
#5
S Sjöström, M Dragoman, S M Fønhus, B Ganatra, K Gemzell-Danielsson
BACKGROUND: Previous systematic reviews have concluded that medical termination of pregnancy (TOP) provided by non-physician providers may be as effective and safe as when provided by physicians. Medical treatment of incomplete miscarriage by non-physicians, and treated women's acceptability with non-physician providers of TOP has not previously been reviewed. OBJECTIVE: To review the effectiveness, safety and acceptability of non-physician provision of first trimester medical TOP including medical treatment for incomplete miscarriage...
April 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28445553/a-novel-rat-head-gaze-determination-system-based-on-optomotor-responses
#6
Mengbo You, Toshiyuki Yamane, Hiroshi Tomita, Eriko Sugano, Takuya Akashi
The optomotor response of animals is commonly used to measure their visual performance, e.g., rats of different genetically altered strains or various drug tests. With the presentation of stimuli using computer screens or projectors, the common idea focuses on measuring the eye movement or head and/or body movement to characterize changes of the head gaze. However, traditional methods rely on either the invasive fixation of animals, or the judgment of a human observer who reports the stimulus-tracking movements...
2017: PloS One
https://www.readbyqxmd.com/read/28445464/burgess-shale-fossils-illustrate-the-origin-of-the-mandibulate-body-plan
#7
Cédric Aria, Jean-Bernard Caron
Retracing the evolutionary history of arthropods has been one of the greatest challenges in biology. During the past decade, phylogenetic analyses of morphological and molecular data have coalesced towards the conclusion that Mandibulata, the most diverse and abundant group of animals, is a distinct clade from Chelicerata, in that its members possess post-oral head appendages specialized for food processing, notably the mandible. The origin of the mandibulate body plan, however, which encompasses myriapods, crustaceans and hexapods, has remained poorly documented...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445434/an-adaptive-clustering-approach-based-on-minimum-travel-route-planning-for-wireless-sensor-networks-with-a-mobile-sink
#8
Jiqiang Tang, Wu Yang, Lingyun Zhu, Dong Wang, Xin Feng
In recent years, Wireless Sensor Networks with a Mobile Sink (WSN-MS) have been an active research topic due to the widespread use of mobile devices. However, how to get the balance between data delivery latency and energy consumption becomes a key issue of WSN-MS. In this paper, we study the clustering approach by jointly considering the Route planning for mobile sink and Clustering Problem (RCP) for static sensor nodes. We solve the RCP problem by using the minimum travel route clustering approach, which applies the minimum travel route of the mobile sink to guide the clustering process...
April 26, 2017: Sensors
https://www.readbyqxmd.com/read/28445373/auricular-reconstruction-in-hemifacial-microsomia-with-an-expanded-two-flap-method
#9
Jin Qian, Zhibin Li, Tun Liu, Xu Zhou, Qingguo Zhang
BACKGROUND: Reconstruction of external ear is important for the child/adult with craniofacial deformities to achieve balance and harmony of the face and head. The aim of this study was to investigate the clinical application of an expanded two-flap method for auricular reconstruction in hemifacial microsomia. METHODS: Between January of 2014 and November of 2015, 111 hemifacial microsomia patients with microtia underwent auricular reconstruction with an expanded two-flap method...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445372/longitudinal-photogrammetric-analysis-of-the-columellar-labial-angle-following-primary-repair-of-bilateral-cleft-lip-and-nasal-deformity
#10
S Alex Rottgers, So Young Lim, Amber M Hall, David Zurakowski, John B Mulliken
BACKGROUND: The changing nasolabial dimensions after repair of bilateral cleft lip and nasal deformity can be documented by anthropometry; however, the columellar-labial angle is rarely measured. METHODS: This is a study of white patients who had synchronous repair of bilateral cleft lip performed by one surgeon (J.B.M.). The columellar-labial angle was measured on lateral photographs with the subject in neutral head position. Average values for columellar-labial angle at two or more time points were analyzed with a general estimating equation and cubic modeling...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445287/prognostic-value-of-pretreatment-18f-fdg-pet-ct-for-nasopharyngeal-carcinoma-patients
#11
Yecai Huang, Mei Feng, Qiao He, Jun Yin, Peng Xu, Qinghua Jiang, Jinyi Lang
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a special subtype of head and neck cancer (HNC). At present, there are no highly specific prognostic markers to aid in tumor grading and guide patient treatment modalities for NPC. The prognostic value of pretreatment F-fluorodeoxyglucose positron emission tomography-computed tomography (F-PET-CT) in NPC patients is controversial and no consensus exists as to its predictive capability. METHODS: To analyze the predictive efficacy of F-PET-CT imaging in NPC patients, data from MEDLINE, EMBASE, the Cochrane library, CBM, CNKI, and VIP (inception to July 2016) were accessed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445183/successful-anesthetic-management-of-morbidly-obese-patients-during-electroconvulsive-therapy-with-the-proseal-laryngeal-mask-airway-in-a-head-up-position-a-report-of-2-cases
#12
Yukihide Koyama, Hiroko Nishioka, Takehiro Ibaraki, Atsushi Ozawa, Naoko Kamoshida, Yuki Akihisa, Tomio Andoh
No abstract text is available yet for this article.
April 25, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28444916/perfectly-alternating-and-regioselective-copolymerization-of-carbonyl-sulfide-and-epoxides-by-metal-free-lewis-pairs
#13
Jia-Liang Yang, Hai-Lin Wu, Yang Li, Xing-Hong Zhang, Donald J Darensbourg
The preparation of perfectly alternating and regioslective copolymers derived from the copolymerization of carbonyl sulfide (COS) and epoxides by metal-free Lewis pair catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (triethyl borane) is described. Colorless and highly transparent copolymers of poly(monothiocarbonate) were successfully obtained with over 99 % tail-to-head content and high molecular weight (up to 92.5 kg mol(-1) ). In most instances, oxygen-sulfur exchange reactions (O/S ERs), which would generate random thiocarbonate and carbonate units, were effectively suppressed...
April 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28444908/micelles-of-the-chiral-biocompatible-surfactant-1r-2s-dodecyl-2-hydroxy-1-methyl-2-phenylethyl-dimethylammonium-bromide-dmeb-molecular-dynamics-and-fragmentation-patterns-in-gas-phase
#14
David Bongiorno, Serena Indelicato, Leopoldo Ceraulo, Ugo Perricone, Valentina Calabrese, Anna Maria Almerico, Vincenzo Turco Liveri, Marco Tutone
RATIONALE: The study of self-assembly process of surfactant molecules in gas phase is of actually interest for several theoretical and technological reasons related to their possible exploitation as drug carriers, protein shields and cleaning agents in gas phase. METHODS: Stability and fragmentation patterns of singly and multiply charged (either positively or negatively) aggregates of the surfactant (1R,2S)-dodecyl(2-hydroxy-1-methyl-2-phenylethyl) dimethyl ammonium bromide (DMEB) in gas phase have been studied by ion mobility mass spectrometry and tandem mass spectrometry...
April 26, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28444831/analysis-of-modulation-factor-to-shorten-the-delivery-time-in-helical-tomotherapy
#15
Hidetoshi Shimizu, Koji Sasaki, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Kuniyasu Nakashima, Kazushi Yokoi, Takashi Kubota, Manabu Yoshimoto, Tohru Iwata, Takeshi Kodaira
A low modulation factor (MF) maintaining a good dose distribution contributes to the shortening of the delivery time and efficiency of the treatment plan in helical tomotherapy. The purpose of this study was to reduce the delivery time using initial values and the upper limit values of MF. First, patients with head and neck cancer (293 cases) or prostate cancer (181 cases) treated between June 2011 and July 2015 were included in the analysis of MF values. The initial MF value (MFinitial ) was defined as the average MFactual value, and the upper limit of the MF value (MFUL ) was defined according the following equation: MFUL = 2 × standard deviation of MFactual value + the average MFactual Next, a treatment plan was designed for patients with head and neck cancer (62 cases) and prostate cancer (13 cases) treated between December 2015 and June 2016...
April 26, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28444830/gene-expression-reveals-evidence-for-egfr-dependent-proximal-distal-limb-patterning-in-a-myriapod
#16
Ralf Janssen
Evolution of segmented limbs is one of the key innovations of Arthropoda, allowing development of functionally specific specialized head and trunk appendages, a major factor behind their unmatched evolutionary success. Proximodistal limb patterning is controlled by two regulatory networks in the vinegar fly Drosophila melanogaster, and other insects. The first is represented by the function of the morphogens Wingless (Wg) and Decapentaplegic (Dpp); the second by the EGFR-signaling cascade. While the role of Wg and Dpp has been studied in a wide range of arthropods representing all main branches, that is, Pancrustacea (= Hexapoda + Crustacea), Myriapoda and Chelicerata, investigation of the potential role of EGFR-signaling is restricted to insects (Hexapoda)...
April 26, 2017: Evolution & Development
https://www.readbyqxmd.com/read/28444799/pixel-wise-estimation-of-noise-statistics-on-iterative-ct-reconstruction-from-a-single-scan
#17
Tonghe Wang, Lei Zhu
PURPOSE: As iterative CT reconstruction continues to advance, the spatial distribution of noise standard deviation (STD) and accurate noise power spectrum (NPS) on the reconstructed CT images become important for method evaluation as well as optimization of algorithm parameters. Using a single CT scan, we propose a practical method for pixel-wise calculation of noise statistics on an iteratively reconstructed CT image, which enables accurate calculation of noise STD for each pixel and NPS...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28444778/development-and-implementation-of-an-84-channel-matrix-gradient-coil
#18
Sebastian Littin, Feng Jia, Kelvin J Layton, Stefan Kroboth, Huijun Yu, Jürgen Hennig, Maxim Zaitsev
PURPOSE: Design, implement, integrate, and characterize a customized coil system that allows for generating spatial encoding magnetic fields (SEMs) in a highly-flexible fashion. METHODS: A gradient coil with a high number of individual elements was designed. Dimensions of the coil were chosen to mimic a whole-body gradient system, scaled down to a head insert. Mechanical shape and wire layout of each element were optimized to increase the local gradient strength while minimizing eddy current effects and simultaneously considering manufacturing constraints...
April 25, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28444772/multi-atlas-approach-with-local-registration-goodness-weighting-for-mri-based-electron-density-mapping-of-head-and-neck-anatomy
#19
Reza Farjam, Neelam Tyagi, Harini Veeraraghavan, Aditya Apte, Kristen Zakian, Margie A Hunt, Joseph O Deasy
PURPOSE: The growing use of magnetic resonance imaging (MRI) as a substitute for computed tomography-based treatment planning requires the development of effective algorithms to generate electron density maps for treatment planning and patient setup verification. The purpose of this work was to develop a method to synthesize computerized tomography (CT) for MR-only radiotherapy of head and neck cancer patients. METHODS: The algorithm is based on registration of multiple patient datasets containing both MRI and CT images (a "multi-atlas" algorithm)...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28444676/-associated-injuries-in-radial-head-fractures
#20
Patrick Vavken, Julia Vavken, Stefan Demarmels, Daniel Rikli
Purpose Radial head fractures, particularly Mason I and II, are considered "harmless" injuries, and their severity is underestimated. In recent years, associated injuries to ligaments, cartilage, and adjacent bones have been studied in more detail. This meta-analysis collects the data on their incidence from the current literature. Methods A systematic review of the online databases PubMed, EMBASE, CINAHL and Cochrane Library was performed to identify clinical studies on associated injuries in radial head fracture...
April 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
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