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https://www.readbyqxmd.com/read/28545184/frequency-of-human-papillomavirus-hpv-16-and-18-detection-in-paraffin-embedded-laryngeal-carcinoma-tissue
#1
Seyed Zinab Hosseini, Manoochehr Makvandi, Alireza Samarbafzade, Ali Timori, Nastaran Ranjbar, Nader Saki, Nilofar Nisi, Toran Shahani, Mehran Varnaseri, Kambiz Angali Ahmadi
Background and Objective: Human papilloma virus (HPV) 16 and HPV18 have been detected in head and neck squamous cell carcinomas (HNSCC) and there is evidence that detection of HPVs would have better prognostic value than patients with HNSCC negative for HPVs. Thus, this study was conducted to evaluate frequency of HPV 16 and HPV 18 genotypes in patients with laryngeal carcinoma. Materials and methods: Fifty formalin-fixed, paraffin-embedded (FFPE) tissue blocks of laryngeal cancers were collected. Sections were prepared at 5 μm and DNA was extracted from each sample and subjected to the polymerase chain reaction (PCR) to detect HPV-16/18 DNA s...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545087/the-second-terminations-of-the-suboccipital-muscles-an-assistant-pivot-for-the-to-be-named-ligament
#2
Xiao-Ying Yuan, Chan Li, Jia-Ying Sui, Qi-Qi Zhao, Xiao Zhang, Na-Na Mou, Zhao Huang-Fu, Okoye Chukwuemeka Samuel, Nan Zheng, Seung-Ho Han, Sheng-Bo Yu, Hong-Jin Sui
In the last two decades, many studies have focused on the muscles and dense connective tissues located in the suboccipital region. Our study investigated the existence of the second terminations originating from the suboccipital muscles, and the relationship between the variable types of the To Be Named Ligament (TBNL). Anatomical dissection was performed on 35 head-neck specimens. The existence of the second terminations of the suboccipital muscles was confirmed and various types of the TBNL were observed in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28544978/documentation-of-50-water-conservation-in-a-single-process-at-a-beef-abattoir
#3
C L Drennan, R E DeOtte, T E Lawrence
Beef slaughter is water intensive due to stringent food safety requirements. We conducted a study at a commercial beef processor to demonstrate water conservation by modifying the mechanical head wash. We documented the initial nozzle configuration (112 nozzles), water pressure (275kPa), and flowrate (152L/head washed), then developed a 3-D CAD model to identify regions of water use redundancy. The mechanical head wash was modified by reducing nozzle count (72), decreasing pressure (138kPa) and flowrate (78...
May 17, 2017: Meat Science
https://www.readbyqxmd.com/read/28544811/differential-protein-expression-in-exosomal-samples-taken-from-trauma-patients
#4
Ron B Moyron, Amber Gonda, Matthew J Selleck, Xian Luo-Owen, Richard D Catalano, Thomas O'Callahan, Carlos Garberoglio, David Turay, Nathan R Wall
Traumatic Brain Injuries (TBI) are among the most misdiagnosed and underreported types of head trauma. The potential long-term impact of undiagnosed or incorrectly identified concussions and other head injuries are potentially devastating, as evidenced by the increasing societal burden exhibited by soldiers returning from combat and athletes in contact sports. Concussions and TBI are notoriously difficult to correctly diagnose and prognosis for these injuries is poorly understood. In order to increase the likelihood of successful diagnosis, treatment, and prediction of outcomes, a definitive differential diagnosis will need to be established...
May 25, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28544809/robotic-radiosurgery-of-head-and-neck-paragangliomas-a-single-institution-experience
#5
İlker Tosun, Banu Atalar, Bilgehan Şahin, Görkem Güngör, Gökhan Aydin, Bülent Yapici, Enis Özyar
AIM: CyberKnife(®) is a robotic stereotactic radiotherapy system. The aim of this study is to evaluate the effectiveness and the safety of CyberKnife(®) on treating head and neck paragangliomas and to report our results. METHODS: Between March 2009 and June 2014, 12 patients with head and neck paragangliomas have been referred to our clinic: in three cases had jugular paragangliomas, five cases had carotid body paragangliomas and three cases had tympanic paragangliomas...
May 24, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28544805/a-comparison-of-attitudes-to-laryngeal-cancer-treatment-outcomes-a-time-trade-off-study
#6
David W Hamilton, Ami Pedersen, Hannah Blanchford, Janneke E Bins, Peter McMeekin, Richard Thomson, Vinidh Paleri, Janet A Wilson
DESIGN: Time trade-off choice experiment. SETTING: Two large head and neck cancer centres. PARTICIPANTS: Patients who have received treatment for head and neck cancer and members of the head and neck cancer multidisciplinary team. MAIN OUTCOME MEASURES: Participants were asked to rank the outcome scenarios, assign utility values using time trade-off and rate the importance of survival on treatment choice. RESULTS: 49 head and neck cancer patients and 73 staff members were recruited...
May 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544782/rationale-and-design-of-amphilimus-sirolimus-eluting-stents-versus-zotarolimus-eluting-stents-in-all-comers-requiring-percutaneous-coronary-intervention-recre8-a-multicenter-randomized-clinical-trial
#7
Rik Rozemeijer, Mèra Stein, Peter Frambach, Michiel Voskuil, Adriaan O Kraaijeveld, Ramón Rodríguez-Olivares, Leo Timmers, Bruno Pereira, Saskia Z Rittersma, Pierfrancesco Agostoni, Pieter A Doevendans, Pieter R Stella
BACKGROUND: Amphilimus sirolimus-eluting stents (A-SES) represent a novel elution technology in the current era of drug-eluting stents with promising results in patients with diabetes mellitus. At present no large trial has been designed to evaluate clinical outcomes of A-SES as compared to new-generation drug-eluting stents in unselected patients. Accordingly, we designed this trial to evaluate clinical noninferiority of A-SES as compared with zotarolimus-eluting stents (ZES) in a real-world, all-comers setting...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28544675/cyclotides-overview-and-biotechnological-applications
#8
REVIEW
Andrew Gould, Julio A Camarero
Cyclotides are globular microproteins with a unique head-to-tail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone topology and knotted arrangement of three disulfide bonds makes them exceptionally stable to chemical, thermal, and biological degradation compared to other peptides of similar size. In addition, cyclotides have been shown to be highly tolerant to sequence variability, aside from the conserved residues forming the cystine knot. Cyclotides can also cross cellular membranes and are able to modulate intracellular protein-protein interactions, both in vitro and in vivo...
May 24, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28544597/metastasis-of-soft-tissue-sarcomas-in-lymph-node-a-cytomorphological-study
#9
Jahnavi Gandhi, Shailee Mehta, Trupti Patel, Amisha Gami, Majal Shah, Dhaval Jetly
BACKGROUND: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. METHOD: A retrospective study over a period by 4 years carried out. FNAC of enlarged lymph node was performed in patients with STS. Cytology smears were examined in conjunction with clinical details...
May 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28544459/plaque-removal-with-triple-headed-vs-single-headed-manual-toothbrushes-a-systematic-review
#10
REVIEW
S M Kalf-Scholte, G A Van der Weijden, Ewp Bakker, D E Slot
OBJECTIVE: The aim of this systematic review was to establish the effectiveness of brushing with a triple-headed manual toothbrush compared to a single-headed manual toothbrush on plaque removal. MATERIALS AND METHODS: The MEDLINE-PubMed and Cochrane-CENTRAL databases were searched. The inclusion criteria were clinical trials conducted with humans without fixed orthodontic appliances who were not dental care professionals. Papers that evaluated the effect of toothbrushing with a triple-headed manual toothbrush compared to a single-headed manual toothbrush on plaque removal were included...
May 22, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28544145/nut-carcinoma-presenting-in-the-palate-a-case-report
#11
Libana Raffoul Bjornstrup, Jesper Reibel, Katalin Kiss, Morten Schioedt
NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773)...
May 25, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28544076/challenges-in-measuring-individual-differences-in-functional-connectivity-using-fmri-the-case-of-healthy-aging
#12
Linda Geerligs, Kamen A Tsvetanov, Cam-Can, Richard N Henson
Many studies report individual differences in functional connectivity, such as those related to age. However, estimates of connectivity from fMRI are confounded by other factors, such as vascular health, head motion and changes in the location of functional regions. Here, we investigate the impact of these confounds, and pre-processing strategies that can mitigate them, using data from the Cambridge Centre for Ageing & Neuroscience (www.cam-can.com). This dataset contained two sessions of resting-state fMRI from 214 adults aged 18-88...
May 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28543996/self-assembly-of-perylenediimide-single-strand-dna-conjugates-employing-hydrophobic-interactions-and-dna-base-pairing-to-create-a-diverse-structural-space
#13
Frederick Lewis, Ashutosh Kumar Mishra, Haim Weissman, Elisha Krieg, Kevin A Voltaw, Martin McCullagh, Boris Rybtchiinski
The self-assembly behavior of DNA conjugates possessing a perylenediimide (PDI) head group and a single N-oligonucleotide tail has been investigated using a combination of optical spectroscopy and cryogenic transmission electron microscopy (cryo-TEM) imaging. In order to obtain insight into the interplay between DNA base pairing and PDI hydrophobic interactions we employed systematic variation in the length and composition of the oligo tails. Conjugates with short (TA)n or (CG)n oligo tails (n ≤ 3) form fibers (helical or nonhelical) constructed from -stacked PDI head groups with pendent oligo tails at room temperature in aqueous solution...
May 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543945/indirect-computed-tomography-lymphangiography-with-aqueous-contrast-for-evaluation-of-sentinel-lymph-nodes-in-dogs-with-tumors-of-the-head
#14
Janet A Grimes, Scott A Secrest, Nicole C Northrup, Corey F Saba, Chad W Schmiedt
Sentinel lymph node evaluation is widely used in human medicine to evaluate the first lymph node(s) to which a tumor drains. Sentinel lymph node biopsy allows avoidance of extensive lymphadenectomies in cases where the sentinel lymph node is negative for metastasis, thereby reducing patient morbidity. It has been shown that regional lymph nodes are not always the sentinel lymph node, thus identification and sampling of sentinel lymph nodes allows for more accurate staging, which is critical for treatment and prognostication in dogs with cancer...
May 21, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28543939/symptom-appraisal-help-seeking-and-lay-consultancy-for-symptoms-of-head-and-neck-cancer
#15
J A Queenan, Benjamin Gottlieb, Deb Feldman-Stewart, Stephen Hall, Jonathan Irish, Patti Groome
BACKGROUND: Early diagnosis is important in head and neck cancer (HNC) patients in order to maximize the effectiveness of the treatments and minimize the debilitation associated with both the cancer and the invasive treatments of advanced disease. Many patients present with advanced disease, and there is little understanding as to why. This study investigated patients' symptom appraisal, help-seeking and lay-consultancy up to the time they first went to see a health care professional (HCP)...
May 23, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28543798/mucosal-melanoma-clinical-histological-and-c-kit-gene-mutational-profile-of-86-french-cases
#16
E Cinotti, J Chevallier, B Labeille, F Cambazard, L Thomas, B Balme, M T Leccia, M D'Incan, P Vercherin, C Douchet, P Rubegni, J L Perrot
BACKGROUND: Mucosal melanomas are rare and highly aggressive tumors. Few studies evaluated mucosal melanomas of locations other than the head and neck region, and other than those of the Asian population. OBJECTIVES: The objective of this study was to analyze the clinical and histological features, as well as the mutational status of c-kit and b-raf gene of mucosal melanoma in any localization in a French series. METHODS: We investigated clinical (sex, age, performance status, survival, treatment of the patients and lack of pigmentation of the tumors) and histopathologic features (ulceration, Breslow's index, mitotic rate), as well as the mutational status of c-kit and b-raf of 86 mucosal melanomas diagnosed in 15 years in four French University Hospitals...
May 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28543787/accurate-determination-of-brain-metabolite-concentrations-using-eretic-as-external-reference
#17
Niklaus Zoelch, Andreas Hock, Susanne Heinzer-Schweizer, Nikolai Avdievitch, Anke Henning
Magnetic Resonance Spectroscopy (MRS) can provide in vivo metabolite concentrations in standard concentration units if a reliable reference signal is available. For (1) H MRS in the human brain, typically the signal from the tissue water is used as the (internal) reference signal. However, a concentration determination based on the tissue water signal most often requires a reliable estimate of the water concentration present in the investigated tissue. Especially in clinically interesting cases, this estimation might be difficult...
May 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543759/abrus-agglutinin-promotes-irreparable-dna-damage-by-triggering-ros-generation-followed-by-atm-p73-mediated-apoptosis-in-oral-squamous-cell-carcinoma
#18
Niharika Sinha, Prashanta Kumar Panda, Prajna Paramita Naik, Durgesh Nandini Das, Subhadip Mukhopadhyay, Tapas K Maiti, Muthu K Shanmugam, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Gautam Sethi, Rajesh Agarwal, Sujit K Bhutia
Oral cancer, a type of head and neck cancer, is ranked as one of the top most malignancies in India. Herein, we evaluated the anticancer efficacy of Abrus agglutinin (AGG), a plant lectin, in oral squamous cell carcinoma. AGG selectively inhibited cell growth, and caused cell cycle arrest and mitochondrial apoptosis through a reactive oxygen species (ROS)-mediated ATM-p73 dependent pathway in FaDu cells. AGG-induced ROS accumulation was identified as the major mechanism regulating apoptosis, DNA damage and DNA-damage response, which were significantly reversed by ROS scavenger N-acetylcysteine (NAC)...
May 23, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28543689/mild-cognitive-impairment-and-structural-brain-abnormalities-in-a-sexagenarian-with-a-history-of-childhood-traumatic-brain-injury
#19
John Darrell Van Horn, Andrei Irimia, Carinna M Torgerson, Avnish Bhattrai, Zachary Jacokes, Paul M Vespa
In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD)...
May 20, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28543647/reflections-on-democratic-deliberation-in-bioethics
#20
Amy Gutmann, James W Wagner
Over the course of six years and more than two dozen meetings, members of the Presidential Commission for the Study of Bioethical Issues learned so many things: about emerging science; technological challenges; citizen engagement; the public's, experts', and our own understandings and misperceptions; and even the nature of our own most cherished values. Our commission's commitment to democratic deliberation began deliberatively, when we decided (in the summer of 2010) upon basic principles to guide our first report...
May 2017: Hastings Center Report
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