keyword
MENU ▼
Read by QxMD icon Read
search

Physiology of ageing

keyword
https://www.readbyqxmd.com/read/29917321/transient-uterine-contractions-as-a-potential-pathology-mimic-on-premenopausal-pelvic-mri-and-the-role-of-routine-repeat-t2-sagittal-images-to-improve-observer-confidence
#1
John Ym Lam, Frank Voyvodic, Melissa Jenkins, Steven Knox
INTRODUCTION: Pelvic MRI has an increasingly important role in the evaluation of non-malignant uterine pathology including uterine leiomyomas, adenomyosis and endometriosis. Normal physiological myometrial junctional zone transient contractions can also be identified on MRI and have the potential to act as pathology mimics. This study aims to evaluate both the incidence of visible physiological contractions in premenopausal female pelvic MRI and also to support the routine acquisition of a repeat T2 sagittal sequence to differentiate transient physiological contractions from true underlying pathology and therefore improve observer confidence...
June 19, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29917053/echocardiographic-strain-analysis-for-the-early-detection-of-left-ventricular-systolic-diastolic-dysfunction-and-dyssynchrony-in-a-mouse-model-of-physiological-aging
#2
Claudio de Lucia, Markus Wallner, Deborah M Eaton, Huaqing Zhao, Steven R Houser, Walter J Koch
Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease and the senescent heart is characterized by structural and functional changes including diastolic and systolic dysfunction as well as left ventricular (LV) dyssynchrony. Speckle-tracking based strain echocardiography (STE) has been shown as a non-invasive, reproducible and highly sensitive methodology to evaluate LV function in both animal models and humans...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29916303/controlled-cortical-impact-severity-results-in-graded-cellular-tissue-and-functional-responses-in-a-piglet-traumatic-brain-injury-model
#3
Emily W Baker, Holly A Kinder, Jessica M Hutcheson, Kylee Jo J Duberstein, Simon R Platt, Elizabeth W Howerth, Franklin D West
A number of preclinical rodent models have been developed in an effort to recapitulate injury mechanisms and identify potential therapeutics for traumatic brain injury (TBI), which is a major cause of death and long-term disability in the United States. However, the lack of restorative treatments for TBI has led to considerable criticism of current preclinical therapeutic development strategies, namely the translatability of widely-used rodent models to human patients. The use of large animal models, such as the pig, with more comparable brain anatomy and physiology to humans may enhance the translational capacity of current preclinical animal models...
June 19, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29916138/paracetamol-in-older-people-towards-evidence-based-dosing
#4
REVIEW
Paola Mian, Karel Allegaert, Isabel Spriet, Dick Tibboel, Mirko Petrovic
Paracetamol is the most commonly used analgesic in older people, and is mainly dosed according to empirical dosing guidelines. However, the pharmacokinetics and thereby the effects of paracetamol can be influenced by physiological changes occurring with ageing. To investigate the steps needed to reach more evidence-based paracetamol dosing regimens in older people, we applied the concepts used in the paediatric study decision tree. A search was performed to retrieve studies on paracetamol pharmacokinetics and safety in older people (> 60 years) or studies that performed a (sub) analysis of pharmacokinetics and/or safety in older people...
June 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29915807/validating-a-commercial-device-for-continuous-activity-measurement-in-the-older-adult-population-for-dementia-management
#5
Tanvi Banerjee, Matthew Peterson, Quintin Oliver, Andrew Froehle, Larry Lawhorne
With the introduction of the large number of fitness devices on the market, there are numerous possibilities for their use in managing chronic diseases in older adults. For example, monitoring people with dementia using commercially available devices that measure heart rate, breathing rate, lung volume, step count, and activity level could be used to predict episodic behavioral and psychological symptoms before they become distressing or disruptive. However, since these devices are designed primarily for fitness assessment, validation of the sensors in a controlled environment with the target cohort population is needed...
January 2018: Smart Health
https://www.readbyqxmd.com/read/29915105/persistent-bacterial-and-fungal-community-shifts-exhibited-in-selenium-contaminated-reclaimed-mine-soils
#6
Carla E Rosenfeld, Bruce R James, Cara Santelli
Mining and other industrial activities worldwide have resulted in Se-enriched surface soils, which pose risks to human and environmental health. Although not well studied, microbial activity can alter Se bioavailability and distribution, even in oxic environments. We used high throughput sequencing to profile bacterial and fungal communities inhabiting mine soils in southeastern Idaho, comparing mined and unmined locations within two reclaimed phosphate mine areas containing variable Se concentrations. The goal was to determine whether microbial communities differed in (i) different mines, (ii) mined areas compared to unmined areas, and (iii) varying soil Se concentrations...
June 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29914938/amino-acid-and-lipid-associated-plasma-metabolomic-patterns-are-related-to-healthspan-indicators-with-aging-in-humans
#7
Lawrence C Johnson, Christopher R Martens, Jessica R Santos-Parker, Candace J Bassett, Talia R Strahler, Charmion Cruickshank-Quinn, Nichole Reisdorph, Matthew B McQueen, Douglas R Seals
Advancing age is associated with impairments in numerous physiological systems, leading to an increased risk of chronic disease and disability, and reduced healthspan (the period of high functioning healthy life). The plasma metabolome is thought to reflect changes in the activity of physiological systems that influence healthspan. Accordingly, we utilized an LC-MS metabolomics analysis of plasma collected from healthy young and older individuals to characterize global changes in small molecule abundances with age...
June 18, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29914854/pancreatic-deletion-of-the-interleukin-1-receptor-disrupts-whole-body-glucose-homeostasis-and-promotes-islet-%C3%AE-cell-de-differentiation
#8
Susan J Burke, Heidi M Batdorf, David H Burk, Thomas M Martin, Tamra Mendoza, Krisztian Stadler, Wateen Alami, Michael D Karlstad, Matthew J Robson, Randy D Blakely, Randall L Mynatt, J Jason Collier
OBJECTIVE: Pancreatic tissue, and islets in particular, are enriched in expression of the interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells are exquisitely sensitive to the IL-1R ligands IL-1α and IL-1β, suggesting that signaling through this pathway regulates health and function of islet β-cells. METHODS: Herein, we report a targeted deletion of IL-1R in pancreatic tissue (IL-1RPdx1-/- ) in C57BL/6J mice and in db/db mice on the C57 genetic background...
June 6, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29914720/physiological-characteristics-self-perceptions-and-parental-support-of-physical-activity-in-children-with-or-at-risk-of-developmental-coordination-disorder
#9
Kemi E Wright, Bonnie J Furzer, Melissa K Licari, Ashleigh L Thornton, James A Dimmock, Louise H Naylor, Siobhan L Reid, Stephanie R Kwan, Ben Jackson
Children with low movement proficiency have been identified as having poorer physiological and psychosocial outcomes; however, the varied measurement approaches used to assess these outcomes have varied resulting in conflicting evidence regarding the presence and magnitude of differences compared to Typically Developing (TD) children. Additionally, there has been limited research into the role of parental support for physical activity (PA) in this group. We compared children with varying levels of movement proficiency on physiological characteristics and self-perceptions regarding PA...
June 16, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29914698/physiological-and-perceptual-responses-in-the-elderly-to-simulated-daily-living-activities-in-uk-summer-climatic-conditions
#10
K A M Waldock, M Hayes, P W Watt, N S Maxwell
OBJECTIVES: The elderly population is at an increasingly significant health risk to heat-related illnesses and mortality when compared with younger people in the same conditions. This is due to an increased frequency and severity of heatwaves, attributed to climate change, and reduced ability of elderly individuals to dissipate excess heat. Consequently, most excess deaths and emergency visits during heatwaves occur in people aged more than 65 years. The aim of this investigation was to assess the physiological and perceptual responses of elderly people during exercise sessions equating to activities of daily living in UK summer climatic conditions...
June 15, 2018: Public Health
https://www.readbyqxmd.com/read/29914555/the-queen-s-gut-refines-with-age-longevity-phenotypes-in-a-social-insect-model
#11
Kirk E Anderson, Vincent A Ricigliano, Brendon M Mott, Duan C Copeland, Amy S Floyd, Patrick Maes
BACKGROUND: In social insects, identical genotypes can show extreme lifespan variation providing a unique perspective on age-associated microbial succession. In honey bees, short- and long-lived host phenotypes are polarized by a suite of age-associated factors including hormones, nutrition, immune senescence, and oxidative stress. Similar to other model organisms, the aging gut microbiota of short-lived (worker) honey bees accrue Proteobacteria and are depleted of Lactobacillus and Bifidobacterium, consistent with a suite of host senescence markers...
June 18, 2018: Microbiome
https://www.readbyqxmd.com/read/29914551/immunotherapy-to-improve-cognition-and-reduce-pathological-species-in-an-alzheimer-s-disease-mouse-model
#12
Krystal Herline, Frances Prelli, Pankaj Mehta, Claire MacMurray, Fernando Goñi, Thomas Wisniewski
BACKGROUND: Alzheimer's disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble oligomers, which contain extensive β-sheet secondary structure, are thought to be the most toxic forms. The objective of this study was to determine the ability of TWF9, an anti-β-sheet conformation antibody (aβComAb), to selectively recognize pathological Aβ and phosphorylated tau in AD human tissue compared with cognitively normal age-matched controls and to improve the performance of old 3xTg-AD mice with advanced pathology in behavioral testing after acute treatment with TWF9...
June 18, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29914307/a-mathematical-modelling-analysis-of-the-response-of-blood-pressure-and-heart-rate-to-submaximal-exercise
#13
Elena Ioana Iconaru, Luminita Georgescu, Constantin Ciucurel
OBJECTIVE: According to Golden ratio (GR) and Fibonacci sequence, models of the organisation of various structures can be encountered in biology, medicine, architecture and engineering. Recent studies indicate that GR can be highlighted in the organisation and physiological functioning of the cardiovascular system. The aim of this study was to investigate the cardiovascular homeostasis during rest and exercise testing by determining the GR validity at the dynamic level of systolic and diastolic blood pressure (SBP, DBP) and heart rate (HR) values...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29914153/dietary-influence-on-body-fluid-acid-base-and-volume-balance-the-deleterious-norm-furthers-and-cloaks-subclinical-pathophysiology
#14
Qi Qian
The popular modern diet, characterized by an excess of animal protein and salt but insufficient in fruits, vegetables and water, is a poor fit for human physiological and homeostatic regulatory systems. Sustained net acid and sodium retention, coupled with an insufficient intake of cardiovascular protective potassium-rich foods and hydration in the modern diet can give rise to debilitating chronic organ dysfunction and ultimately, mortality. This holds true, especially in our aging population who are already facing inevitable decline in organ functional reserve...
June 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29913782/translational-animal-models-using-veterinary-patients-an-example-of-canine-osteoarthritis-oa
#15
Outi Vainio
Background and purpose The use of laboratory animals in pain research has powerfully contributed to our detailed understanding of the physiological mechanisms of pain. Animal models also represent an essential tool to screen and select novel drug molecules with potentially analgesic properties. Despite of the inevitable input of laboratory animal trials, recent studies have shown that animal pain models have repeatedly failed to predict clinical analgesic efficacy and adverse side effects of potential drug molecules in human pain patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913712/psychological-factors-in-genital-pain-the-role-of-fear-avoidance-pain-catastrophizing-and-anxiety-sensitivity-among-women-living-in-sweden
#16
Johanna Thomtén, Andreas Karlsson
Objectives One in five women under the age of 30 report recurrent genital pain and pain during sexual intercourse. Female genital pain negatively affects sexual and general health, as well as dyadic function and quality of life. Although the current field of research and clinical expertise in general agree upon a biopsychosocial conceptualization, there is still a lack of theoretical models describing the psychosocial mechanisms involved in the development of genital pain. Originally developed to outline the transition from acute to chronic back pain, the fear avoidance (FA) model has lately been proposed as a possible tool in illustrating the mechanisms involved in genital pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913665/living-with-genital-pain-sexual-function-satisfaction-and-help-seeking-among-women-living-in-sweden
#17
Johanna Thomtén
Background and aims Female genital pain is a debilitating problem that negatively affects several aspects of the life of women. Several studies present figures of prevalence indicating that the problem affects nearly 20% of young women. However, many women fail to consult health care and the estimated prevalence therefore remains insecure. Historically, genital pain was commonly viewed as either physiological or psychosexual. Although the current field of research and clinical expertise in general agree upon a biopsychosocial conceptualization, less is known about the manifestation of the problem in everyday life and the experience of seeking health care among afflicted women...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913651/effectiveness-of-multidisciplinary-rehabilitation-treatment-for-patients-with-chronic-pain-in-a-primary-health-care-unit
#18
Klaus Felix Stein, Adriana Miclescu
Background In recent years, multidisciplinary rehabilitation (MDR) became an alternative treatment option for chronic non-cancer pain. MDR is mostly available in specialized pain units, usually at rehabilitation centers where the level of knowledge and therapeutically options to treat pain conditions are considered to be high. There is strong evidence that MDR in specialized pain units is affecting pain and improves the quality of life in a sustainable manner. There are few studies about MDR outcome in primary health care, especially in those units situated in rural areas and with a different population than that encountered in specialized hospitals...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913536/hemostasis-in-the-very-young
#19
Gili Kenet, Assaf Arie Barg, Ulrike Nowak-Göttl
Hemostasis is a dynamic process that starts in utero. The coagulation system evolves with age, as evidenced by marked physiological differences in the concentration of the majority of hemostatic proteins in early life compared with adulthood. This concept, known as "developmental hemostasis," has important biological and clinical implications. Overall, impaired platelet function, along with physiologically reduced levels of vitamin K-dependent and contact coagulation factors, may cause poorer clot firmness even in healthy neonates...
June 18, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29912353/nutritional-impact-on-mammary-development-in-pigs-a-review
#20
Chantal Farmer
Milk yield is a crucial component of a sow operation because it is a limiting factor for piglet growth rate. Stimulating mammary development is one avenue that could be used to improve sow milk production. A number of studies have shown that nutrition of gilts or sows during the periods of rapid mammary accretion occurring during prepuberty, gestation, and lactation can affect mammary development. The present review provides an overview of all the information currently published on the subject and Table 1 summarizes the dietary treatments that enhance mammary development in pigs...
June 15, 2018: Journal of Animal Science
keyword
keyword
40479
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"