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Physiology of ageing

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https://www.readbyqxmd.com/read/29241214/nasalance-variability-in-3-to-5-year-old-children-during-production-of-speech-stimulus-in-three-vowel-contexts
#1
Seunghee Ha, Ilsan Shin
OBJECTIVE: The purpose of this study was to determine whether age and vowel contexts influence test-retest nasalance score variability in typically developing Korean children. PARTICIPANTS: Forty-five 3- to 5-year-old children with normal speech and resonance participated in the study. METHODS: All subjects were asked to repeat three 4-syllable speech stimuli in high, low, or mixed vowel contexts twice after the examiner. An immediate test-retest nasalance score was assessed with no headgear change...
December 14, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29241024/age-and-gender-associated-liver-physiological-t1rho-dynamics-demonstrated-with-a-clinically-applicable-single-breathhold-acquisition
#2
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony W L Kwok, Eric K W Liu, Weitian Chen
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29241018/older-women-exhibit-greater-airway-8-isoprostane-responses-to-strenuous-exercise-compared-to-older-men-and-younger-controls
#3
Stephanie P Kurti, Sam R Emerson, Joshua R Smith, Sara K Rosenkranz, Samantha A Alexander, Garrett M Lovoy, Craig A Harms
INTRODUCTION: Development of late-onset respiratory diseases is associated with elevated 8-isoprostane, a marker of oxidative stress, in the airways. However, sex differences exist in development of these diseases. Using an exhaustive exercise bout as a physiological stressor may elucidate whether there is a sex difference with aging in pre- to post-exercise airway 8-isoprostane generation. PURPOSE: To determine whether older women exhibit a greater airway 8-isoprostane response to exhaustive exercise compared to older men and younger controls...
December 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29240901/daily-social-interactions-and-the-biological-stress-response-are-there-age-differences-in-links-between-social-interactions-and-alpha-amylase
#4
Kira S Birditt, Lauren A Tighe, Michael R Nevitt, Steven H Zarit
Background and Objectives: According to the strength and vulnerability integration (SAVI) model, older people are better able to avoid negative social interactions than younger people, but when they do experience negative interactions, they are equally or more emotionally and physiologically reactive than younger people. Less is known about the links between daily negative and positive social encounters and the sympathetic adrenal medullary system (a key stress pathway) and whether there are age differences in these links...
December 12, 2017: Gerontologist
https://www.readbyqxmd.com/read/29240797/a-mucoadhesive-thermoreversible-in-situ-nasal-gel-of-geniposide-for-neurodegenerative-diseases
#5
Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bie
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide...
2017: PloS One
https://www.readbyqxmd.com/read/29240691/absence-of-correlation-between-chimeric-rna-and-aging
#6
Reyna Huang, Shailesh Kumar, Hui Li
Chimeric RNAs have been recognized as a phenomenon not unique to cancer cells. They also exist in normal physiology. Aging is often characterized by deregulation of molecular and cellular mechanisms, including loss of heterochromatin, increased transcriptional noise, less tight control on alternative splicing, and more stress-induced changes. It is thus assumed that chimeric RNAs are more abundant in older people. In this study, we conducted a preliminary investigation to identify any chimeric RNAs with age-based trends in their expression levels in blood samples...
December 14, 2017: Genes
https://www.readbyqxmd.com/read/29240656/hospital-acquired-pressure-injury-risk-adjusted-comparisons-in-an-integrated-healthcare-delivery-system
#7
June Rondinelli, Stephen Zuniga, Patricia Kipnis, Lina Najib Kawar, Vincent Liu, Gabriel J Escobar
BACKGROUND: Although healthcare organizations have decreased hospital-acquired pressure injury (HAPI) rates, HAPIs are not eliminated, driving further examination in both nursing and health services research. OBJECTIVE: The objective was to describe HAPI incidence, risk factors, and risk-adjusted hospital variation within a California integrated healthcare system. METHODS: Inpatient episodes were included in this retrospective cohort if patients were hospitalized between January 1, 2013, and June 30, 2015...
January 2018: Nursing Research
https://www.readbyqxmd.com/read/29240651/acute-impact-of-different-exercise-modalities-on-arterial-and-platelet-function
#8
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, P Hugh R Barrett, Louise H Naylor, Daniel J Green
PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29239995/development-of-anaerobic-fitness-in-top-level-competitive-youth-ice-hockey-players
#9
Jeff R Leiter, Dean M Cordingley, Peter B MacDonald
Ice hockey is a physiologically complex sport involving both the anaerobic and aerobic energy systems. The purpose of this study was to evaluate the anaerobic power output (PO) of top-level competitive youth hockey players. It was hypothesized that with each successive increase in age there would be an associated change in anaerobic PO. Two hundred and fifty-one male hockey players between the ages of 13-17 years of age participated in this study. All athletes completed a 30-second Wingate test as part of a pre-season physiological and fitness combine...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239992/comparison-of-resistance-based-walking-cardiorespiratory-test-to-the-bruce-protocol
#10
Christopher P Hurt, Marcas Bamman, Avantika Naidu, David A Brown
Cardiorespiratory fitness is assessed through graded exercise tests that determine the maximum amount of sustained mechanical work that an individual can perform while also providing health and fitness related information. This manuscript describes a novel method to perform graded exercise tests that uses posteriorly directed resistive forces. The purpose of this investigation is to validate a novel resistance based test in comparison to a traditional speed and incline based test in a cohort of non-impaired individuals...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29239637/discrete-emotion-regulation-strategy-repertoires-and-parasympathetic-physiology-characterize-psychopathology-symptoms-in-childhood
#11
Laura E Quiñones-Camacho, Elizabeth L Davis
Certain psychopathologies are often linked to dysregulation of specific emotions (e.g., anxiety is associated with dysregulation of fear), but few studies have examined how regulatory repertoires for specific emotions (e.g., the strategies a person uses to regulate fear) relate to psychopathology, and fewer still have examined this in childhood. A total of 106 7- to 11-year-olds (M = 9.37 years; SD = 1.30; 44% girls) participated in a multimethod investigation of emotion regulation and psychopathology. Parents reported on family characteristics and children's symptoms...
December 14, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29239310/micrornas-as-diagnostic-markers-and-therapeutic-targets-for-traumatic-brain-injury
#12
REVIEW
Bridget Martinez, Philip V Peplow
Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days after the trauma, and provide valuable therapeutic targets to prevent further neuronal degeneration. At the present time, there is no effective treatment for TBI due, in part, to the widespread impact of numerous complex secondary biochemical and pathophysiological events occurring at different time points following the initial injury...
November 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29238999/physiological-gas-exchange-mapping-of-hyperpolarized-129-xe-using-spiral-ideal-and-moxe-in-a-model-of-regional-radiation-induced-lung-injury
#13
Brandon Zanette, Elaine Stirrat, Salomeh Jelveh, Andrew Hope, Giles Santyr
PURPOSE: To map physiological gas exchange parameters using dissolved hyperpolarized (HP) 129 Xe in a rat model of regional radiation-induced lung injury (RILI) with spiral-IDEAL and the model of xenon exchange (MOXE). Results are compared to quantitative histology of pulmonary tissue and red blood cell (RBC) distribution. METHODS: Two cohorts (n=6 each) of age-matched rats were used. One was irradiated in the right-medial lung, producing regional injury. Gas exchange was mapped four weeks post-irradiation by imaging dissolved-phase HP 129 Xe using spiral-IDEAL at five gas exchange timepoints using a clinical 1...
December 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29238921/bacillus-probiotic-supplementations-improve-laying-performance-egg-quality-hatching-of-laying-hens-and-sperm-quality-of-roosters
#14
Maria S Mazanko, Ivan F Gorlov, Evgeniya V Prazdnova, Maxim S Makarenko, Alexander V Usatov, Anzhelika B Bren, Vladimir A Chistyakov, Alexey V Tutelyan, Zoya B Komarova, Natalia I Mosolova, Denis N Pilipenko, Olga E Krotova, Aleksandr N Struk, Angela Lin, Michael L Chikindas
The study aims at elucidating the effect of bacilli probiotic preparations on the physiology of laying hens and roosters. Probiotic formulations were prepared as soybean products fermented by Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895. In this study, groups of male and female chickens were used. These groups received a probiotic preparation based on either B. subtilis KATMIRA1933 or B. amyloliquefaciens B-1895, or of a mixture of strains, from the first day to the age of 39 weeks. These preparations positively affected egg production, quality of sperm production, and quality and hatchery of eggs...
December 13, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29238569/transient-cardiac-dysfunction-but-elevated-cardiac-and-kidney-biomarkers-24%C3%A2-h-following-an-ultra-distance-running-event-in-mexican-tarahumara
#15
Dirk L Christensen, Diana Espino, Rocío Infante-Ramírez, Mónica S Cervantes-Borunda, Rosa P Hernández-Torres, Antonio E Rivera-Cisneros, Daniel Castillo, Kate Westgate, Dijana Terzic, Soren Brage, Christian Hassager, Jens P Goetze, Jesper Kjaergaard
Background: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population. Thus, we aimed to investigate the acute impact (≤ 24 h) on functional and biochemical changes of the cardiac muscle and biochemical changes associated with kidney function following a 63-km ultra-distance race with an altitude difference of 1800 m in Mexican Tarahumara athletes...
2017: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/29238517/exogenous-h2s-restores-ischemic-post-conditioning-induced-cardioprotection-through-inhibiting-endoplasmic-reticulum-stress-in-the-aged-cardiomyocytes
#16
Weiming Sun, Jinxia Yang, Yuanzhou Zhang, Yuxin Xi, Xin Wen, Di Yuan, Yuehong Wang, Can Wei, Rui Wang, Lingyun Wu, Hongzhu Li, Changqing Xu
Background: A gasotransmitter hydrogen sulfide (H2S) plays an important physiological and pathological role in cardiovascular system. Ischemic post-conditioning (PC) provides cardioprotection in the young hearts but not in the aged hearts. Exogenous H2S restores PC-induced cardioprotection by inhibition of mitochondrial permeability transition pore opening and oxidative stress and increase of autophagy in the aged hearts. However, whether H2S contributes to the recovery of PC-induced cardioprotection via down-regulation of endoplasmic reticulum stress (ERS) in the aged hearts is unclear...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29238257/validation-of-an-arm-crank-ergometer-test-for-use-in-sedentary-adults
#17
Alexandros Mitropoulos, Anil Gumber, Helen Crank, Markos Klonizakis
The maximal oxygen uptake (V̇O2peak) test is an approved pre-operative examination tool, in a clinical setting: Both V̇O2peak and anaerobic threshold indicate a patient's physiological tolerance for major surgery and post-operative mortality, with cycle ergometry being routinely used for V̇O2peak tests in clinical settings, in many European countries. Nevertheless, the opportunities to assess populations with restricted mobility of the lower limbs are limited, as alternative methods (such as an arm-crank test protocol) to assess V̇O2peak are yet to be established...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29238182/adherence-to-a-copd-treatment-guideline-among-patients-in-hong-kong
#18
Ka Pang Chan, Fanny Ws Ko, Hok Sum Chan, Mo Lin Wong, Thomas Yw Mok, Kah Lin Choo, David Sc Hui
Background: This study aimed to assess the adherence rate of pharmacological treatment to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline published in 2011 and the prevalence of comorbidities among patients with COPD in Hong Kong (HK). Methods: Patients were recruited from five tertiary respiratory centers and followed up for 12 months. Data on baseline physiological, spirometric parameters, use of COPD medications and coexisting comorbidities were collected...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29237616/individual-differences-in-normal-body-temperature-longitudinal-big-data-analysis-of-patient-records
#19
Ziad Obermeyer, Jasmeet K Samra, Sendhil Mullainathan
OBJECTIVE: To estimate individual level body temperature and to correlate it with other measures of physiology and health. DESIGN: Observational cohort study. SETTING: Outpatient clinics of a large academic hospital, 2009-14. PARTICIPANTS: 35 488 patients who neither received a diagnosis for infections nor were prescribed antibiotics, in whom temperature was expected to be within normal limits. MAIN OUTCOME MEASURES: Baseline temperatures at individual level, estimated using random effects regression and controlling for ambient conditions at the time of measurement, body site, and time factors...
December 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29237575/acclimation-capacity-of-the-cardiac-hsp70-and-hsp90-response-to-thermal-stress-in-lake-trout-salvelinus-namaycush-a-stenothermal-ice-age-relict
#20
Nicholas I Kelly, Chris C Wilson, Suzanne Currie, Gary Burness
The ability of cold-adapted species to persist in the face of climate change will depend on the capacity of individuals for thermal acclimation, adaptation, and the degree of physiological variation that exists among populations. We tested the acclimation capacity of cardiac HSP70 and HSP90 in four populations of lake trout (Salvelinus namaycush), a cold-adapted salmonid. We acclimated fish to four temperatures (8°C, 11°C, 15°C, and 19°C) and measured cardiac HSP70 and HSP90 levels by western blot prior to and following an acute (1h) heat shock at 23°C...
December 10, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
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