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https://www.readbyqxmd.com/read/29669697/the-prevalence-of-sarcopaenia-in-a-vascular-surgical-patient-cohort-and-its-impact-on-outcome
#1
Rachel Heard, Douglas Black, George Ramsay, Neil Scott, Diane Hildebrand
BACKGROUND: Sarcopaenia, loss of lean muscle mass and quality, has prognostic significance and can be used to guide the management of oncology patients.1 However, there is limited research into the prevalence and effect of sarcopaenia in vascular populations. We aim to investigate the prevalence of this measure of physiological reserve in a vascular patient group. METHODS: All patients admitted to a tertiary vascular unit in a single year were considered for the study...
April 16, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29662761/inflammation-and-age-associated-skeletal-muscle-deterioration-sarcopaenia
#2
REVIEW
Jinyu Wang, Kwok-Sui Leung, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Ageing is accompanied by chronic inflammatory responses due to elevated circulatory inflammatory cytokine production. Several inflammatory cytokines have been shown to be responsible for a decrease in muscle mass. However, little is known about the possible relationship between inflammation and sarcopaenia. This review aims to summarise the existing evidence about inflammation and sarcopaenia. Sarcopaenia is defined as an age-related decrease of muscle mass and/or muscle strength; it is caused by multiple factors, such as skeletal muscle atrophy, neuromuscular junction degeneration, hormone imbalance, cytokine imbalance, protein synthesis and proteolysis...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29540996/protein-for-life-towards-a-focussed-dietary-framework-for-healthy-ageing
#3
E J Stevenson, A W Watson, J M Brunstrom, B M Corfe, M A Green, A M Johnstone, E A Williams
'Ageing well' has been highlighted as an important research area by the World Health Organization. In the UK, healthy ageing has been identified as a priority research area by multiple Research Councils and is a key NHS priority. Sarcopaenia, the decline of muscle mass/strength and a key component of healthy ageing, can have a major impact on quality of life and is associated with premature mortality. Increasing protein intake at all stages of the life course may help to reduce the rate of muscle decline and the onset of associated health conditions...
March 2018: Nutrition Bulletin
https://www.readbyqxmd.com/read/29482152/age-socioeconomic-patterns-and-regional-variations-in-grip-strength-among-older-adults-50-in-india-evidence-from-who-sage
#4
P Arokiasamy, Y Selvamani
BACKGROUND: Muscle strength, measured as grip strength is a potential marker of bodily function and sarcopaenia. Yet, not much is known about its patterns and correlates among older population in India. This study assesses the age and socioeconomic patterns and state variations in grip strength among older adults (50+) in India. METHODS: A cross-sectional and nationally representative data from the first wave of WHO's Study on global Ageing and Adult Health (SAGE) -2007 (n = 6262) was used...
February 19, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29391380/protein-enriched-milk-based-supplement-to-counteract-sarcopenia-in-acutely-ill-geriatric-patients-offered-resistance-exercise-training-during-and-after-hospitalisation-study-protocol-for-a-randomised-double-blind-multicentre-trial
#5
Josephine Gade, Anne Marie Beck, Christian Bitz, Britt Christensen, Tobias Wirenfeldt Klausen, Anders Vinther, Arne Astrup
INTRODUCTION: Age-related loss of muscle mass and strength, sarcopaenia, burdens many older adults. The process is accelerated with bed rest, protein intakes below requirements and the catabolic effect of certain illnesses. Thus, acutely ill, hospitalised older adults are particularly vulnerable. Protein supplementation can preserve muscle mass and/or strength and, combining this with resistance exercise training (RT), may have additional benefits. Therefore, this study investigates the effect of protein supplementation as an addition to offering RT among older adults while admitted to the geriatric ward and after discharge...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29259793/effect-of-physical-exercise-on-sarcopaenia-in-patients-with-overt-hepatic-encephalopathy-a-study-protocol-for-a-randomised-controlled-trial
#6
Kazunori Yoh, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Kunihiro Hasegawa, Chikage Nakano, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
Introduction: Limited data are currently available for patients with overt hepatic encephalopathy (OHE)) receiving physical exercise (PE). The aim of the current study is to prospectively examine the effect of PE on sarcopaenia in patients with OHE. Methods and analysis: At the time of patient recruitment, a precise assessment for nutritional status and daily physical activities will be performed in each subject. Study participants will be randomly assigned into two groups: (1) the PE group and (2) the control group...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28781962/inflammation-and-its-resolution-and-the-musculoskeletal-system
#7
Jiri Gallo, Milan Raska, Eva Kriegova, Stuart B Goodman
Inflammation, an essential tissue response to extrinsic/intrinsic damage, is a very dynamic process in terms of complexity and extension of cellular and metabolic involvement. The aim of the inflammatory response is to eliminate the pathogenic initiator with limited collateral damage of the inflamed tissue, followed by a complex tissue repair to the preinflammation phenotype. Persistent inflammation is a major contributor to the pathogenesis of many musculoskeletal diseases including ageing-related pathologies such as osteoporosis, osteoarthritis, and sarcopaenia...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/28721127/diabetes-in-the-elderly
#8
REVIEW
Katarzyna Mordarska, Małgorzata Godziejewska-Zawada
The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycaemia are as follows: deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopaenia. Clinical features of diabetes in the elderly could be different. Diabetes in elderly people is often diagnosed with delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycaemia...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28684167/sarcopaenia-in-surgical-populations-a-review
#9
REVIEW
Rachel S M Heard, George Ramsay, Diane R Hildebrand
Sarcopaenia, or decreased muscle mass, has been the subject of a large quantity of recent literature in both medical and surgical disciplines. It has been shown, as outlined below, to be of great prognostic importance, and also may be used in certain circumstances to guide treatment. The greatest volume of research into this topic is in oncological surgical populations, in whom the prevalence of sarcopaenia has been shown to be high. However it is being increasingly studied in other patient groups. Interest in using sarcopaenia as an objective and potentially modifiable marker of frailty is increasing, especially with regards to pre-operative risk stratification and amelioration...
December 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28665444/prevalence-of-sarcopenia-and-its-association-with-dysphagia-in-cancer-patients-who-require-rehabilitation
#10
Hidetaka Wakabayashi, Rimiko Takahashi, Naoko Watanabe, Hideyuki Oritsu, Yoshitaka Shimizu
OBJECTIVE: To assess the prevalence of sarcopaenia and the association between sarcopaenia, activities of daily living, and dysphagia in cancer patients who require rehabilitation. METHODS: A cross-sectional study was performed in 83 consecutive cancer patients referred to the Department of Rehabilitation Medicine. Skeletal muscle index was calculated as total psoas muscle area assessed via abdominal computed tomography divided by height squared. Sarcopaenia was diagnosed using the Asian Working Group for Sarcopenia criteria...
August 31, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28539680/sarcopaenia-and-rheumatoid-arthritis
#11
REVIEW
Tomasz Targowski
In October 2016 a new independent disease called sarcopaenia (according to ICD-10 classification) appeared. According to the recommendation of the European Working Group on Sarcopenia in Older People (EWGSOP), sarcopaenia is defined as abnormally low muscle mass plus low skeletal muscle strength or low physical performance. Sarcopaenia, as a primary disease, is mainly observed in older people, but it can also appear in younger adults in the course of many clinical chronic conditions. One of the most frequent chronic diseases associated with chronic inflammation and functional limitation of skeletal system is rheumatoid arthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28420250/the-european-association-of-preventive-cardiology-exercise-prescription-in-everyday-practice-and-rehabilitative-training-expert-tool-a-digital-training-and-decision-support-system-for-optimized-exercise-prescription-in-cardiovascular-disease-concept-definitions
#12
Dominique Hansen, Paul Dendale, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Josef Niebauer, Veronique Cornelissen, Roberto Pedretti, Eva Geurts, Gustavo R Ruiz, Ugo Corrà, Jean-Paul Schmid, Eugenio Greco, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona S Braga, Olga Barna, Paul Beckers, Maurizio Bussotti, Robert Fagard, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Daniel Neunhäuserer, Rona Reibis, Martijn A Spruit, Christoph Stettler, Tim Takken, Cajsa Tonoli, Carlo Vigorito, Heinz Völler, Patrick Doherty
Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training and decision support system for exercise prescription in cardiovascular disease patients in clinical practice: the European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool...
July 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28316139/changes-in-body-composition-and-metabolic-profile-during-interleukin-6-inhibition-in-rheumatoid-arthritis
#13
Anne Tournadre, Bruno Pereira, Fréderic Dutheil, Charlotte Giraud, Daniel Courteix, Vincent Sapin, Thomas Frayssac, Sylvain Mathieu, Sandrine Malochet-Guinamand, Martin Soubrier
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti-interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA...
August 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27456324/impact-of-physical-function-impairment-and-multimorbidity-on-mortality-among-community-living-older-persons-with-sarcopaenia-results-from-the-ilsirente-prospective-cohort-study
#14
Francesco Landi, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Roberto Bernabei, Graziano Onder, Emanuele Marzetti
OBJECTIVE: Sarcopaenia and physical function impairment may have a greater effect on survival than other clinical characteristics, including multimorbidity. In this study, we evaluated the impact of sarcopaenia on all-cause mortality and the interaction among muscle loss, physical function impairment and multimorbidity on mortality risk over 10 years in older community-dwellers. DESIGN: Prospective cohort study. SETTING: Population-based study...
July 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27050381/hypogonadotropic-hypogonadism-and-metabolic-syndrome-insights-from-the-high-fat-diet-experimental-rabbit-animal-model
#15
REVIEW
Annamaria Morelli, Linda Vignozzi, Mario Maggi
The etiology of metabolic syndrome (MetS) is complex and involves the interplay between environmental, lifestyle and genetic determinants. MetS in men can be associated with a biochemical pattern of partial hypogonadotropic hypogonadism (HH). A similar pattern has been noted in both men and women with a variety of acute illnesses and chronic diseases, and there is ongoing debate regarding whether this phenomenon might adaptive (e.g. diverting resources from reproduction into survival), or maladaptive (e.g. anemia, sarcopenia, osteopenia and fatigue of androgen-deficiency amplify and widen the adverse consequences of the original disease-trigger)...
June 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/26857389/dietary-protein-intake-is-associated-with-better-physical-function-and-muscle-strength-among-elderly-women
#16
Masoud Isanejad, Jaakko Mursu, Joonas Sirola, Heikki Kröger, Toni Rikkonen, Marjo Tuppurainen, Arja T Erkkilä
Dietary protein intake might be beneficial to physical function (PF) in the elderly. We examined the cross-sectional and prospective associations of protein intake of g/kg body weight (BW), fat mass (FM) and lean mass (LM) with PF in 554 women aged 65·3-71·6 years belonging to the Osteoporosis Risk Factor and Prevention Fracture Prevention Study. Participants filled a questionnaire on lifestyle factors and 3-d food record in 2002. Body composition was measured by dual-energy X-ray absorptiometry, and PF measures were performed at baseline and at 3-year follow-up...
April 14, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26785481/gut-microbiota-and-aging
#17
REVIEW
Paul W O'Toole, Ian B Jeffery
The potential for the gut microbiota to affect health has a particular relevance for older individuals. This is because the microbiota may modulate aging-related changes in innate immunity, sarcopaenia, and cognitive function, all of which are elements of frailty. Both cell culture-dependent and -independent studies show that the gut microbiota of older people differs from that of younger adults. There is no chronological threshold or age at which the composition of the microbiota suddenly alters; rather, changes occur gradually with time...
December 4, 2015: Science
https://www.readbyqxmd.com/read/26344457/forensic-issues-at-the-extremes-of-weight-from-frailty-syndrome-through-frail-obesity-to-morbid-obesity
#18
Roger W Byard
It is well recognised that there has been a striking increase in average body size (measured by the body mass index) in a number of countries over recent years, such that it has been referred to as an obesity epidemic. This has been associated with increased numbers of these cases in the forensic mortuary with the associated practical difficulties in body handling and the complexities of identifying multiple comorbidities. At the other extreme of body weight lies the frailty syndrome which manifests with unintentional weight loss, decreased muscle mass (sarcopaenia), reduced physical strength and activity, exhaustion and slow ambulation...
October 2015: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/25772036/sarcopaenia-is-associated-with-nafld-independently-of-obesity-and-insulin-resistance-nationwide-surveys-knhanes-2008-2011
#19
MULTICENTER STUDY
Yong-Ho Lee, Kyu Sik Jung, Seung Up Kim, Hye-Jin Yoon, Yu Jung Yun, Byung-Wan Lee, Eun Seok Kang, Kwang-Hyub Han, Hyun Chul Lee, Bong-Soo Cha
BACKGROUND & AIMS: Although sarcopaenia is associated with obesity-related comorbidities, its influence on non-alcoholic fatty liver disease (NAFLD) or steatohepatitis has not been fully determined. We aimed to investigate the direct relationship between sarcopaenia and NAFLD or steatohepatitis in the general population. METHODS: We conducted a cross-sectional study using nationally representative samples of 15,132 subjects from the Korea National Health and Nutrition Examination Surveys 2008-2011...
August 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25628049/evidence-of-and-recommendations-for-non-pharmacological-interventions-for-common-geriatric-conditions-the-senator-ontop-systematic-review-protocol
#20
REVIEW
Iosief Abraha, Alfonso Cruz-Jentoft, Roy L Soiza, Denis O'Mahony, Antonio Cherubini
INTRODUCTION: Non-pharmacological therapies for common chronic medical conditions in older patients are underused in clinical practice. We propose a protocol for the assessment of the evidence of non-pharmacological interventions to prevent or treat relevant outcomes in several prevalent geriatric conditions in order to provide recommendations. METHODS AND ANALYSIS: The conditions of interest for which the evidence about efficacy of non-pharmacological interventions will be searched include delirium, falls, pressure sores, urinary incontinence, dementia, heart failure, orthostatic hypotension, sarcopaenia and stroke...
January 27, 2015: BMJ Open
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