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Elizabeth Curry, Tamara K Oser, Sean M Oser
BACKGROUND AND OBJECTIVES: Electronic Health Record (EHR) use in clinical practice has accelerated in recent years. While several aspects of EHR use have been extensively studied, there is little data on EHR impacts on medical student educators, especially those involved in outpatient family medicine. This study evaluated perceived impacts of EHR use on clinician teachers of outpatient family medicine. METHODS: The study used a mixed methods survey of clinicians who teach third-year medical students during the required family and community medicine outpatient clerkship at a Mid-Atlantic medical school...
October 2017: Family Medicine
Philipp Wortmann, Markus Götz, Thorsten Hugel
The function of the molecular chaperone Hsp90 depends on large conformational changes, the rearrangement of local motifs, and the binding and hydrolysis of ATP. The size and complexity of the Hsp90 system impedes the detailed investigation of their interplay using standard methods. To overcome this limitation, we developed a three-color single-molecule FRET assay to study the interaction of Hsp90 with a fluorescently labeled reporter nucleotide in detail. It allows us to directly observe the cooperativity between the two nucleotide binding pockets in the protein dimer...
October 17, 2017: Biophysical Journal
Ephantus J Muturi, Jose L Ramirez, Alejandro P Rooney, Chang-Hyun Kim, Brenda Beerntsen
The potential for gut microbiota to impede or enhance pathogen transmission is well-documented but the factors that shape this microbiota in mosquito vectors are poorly understood. We characterized and compared the gut microbiota of adult females of Culex restuans (Theobald; Diptera: Culicidae) from different parents. Cx. restuans larvae from nine field-collected egg rafts were reared on a common diet and gut microbiota of newly emerged adult females characterized by MiSeq sequencing of the V4 hypervariable region of the 16S rRNA gene...
October 17, 2017: Journal of Medical Entomology
Cynthia Nau Cornelissen
The pathogenic Neisseria species, including Neisseria meningitidis and Neisseria gonorrhoeae, are obligate human pathogens that cause significant morbidity and mortality. The success of these pathogens, with regard to causing disease in humans, is inextricably linked to their ability to acquire necessary nutrients in the hostile environment of the host. Humans deploy a significant arsenal of weaponry to defend against bacterial pathogens, not least of which are the metal sequestering proteins that entrap and withhold transition metals, including iron, zinc and manganese, from invaders...
October 13, 2017: Pathogens and Disease
C Nestler, P Simon, D Petroff, S Hammermüller, D Kamrath, S Wolf, A Dietrich, L M Camilo, A Beda, A R Carvalho, A Giannella-Neto, A W Reske, H Wrigge
Background: General anaesthesia leads to atelectasis, reduced end-expiratory lung volume (EELV), and diminished arterial oxygenation in obese patients. We hypothesized that a combination of a recruitment manoeuvre (RM) and individualized positive end-expiratory pressure (PEEP) can avoid these effects. Methods: Patients with a BMI ≥35 kg m-2 undergoing elective laparoscopic surgery were randomly allocated to mechanical ventilation with a tidal volume of 8 ml kg-1 predicted body weight and (i) an RM followed by individualized PEEP titrated using electrical impedance tomography (PEEPIND) or (ii) no RM and PEEP of 5 cm H2O (PEEP5)...
October 16, 2017: British Journal of Anaesthesia
Sahar Salehi, Rebecca A Sosa, Yi-Ping Jin, Shoichi Kageyama, Michael C Fishbein, Enrique Rozengurt, Jerzy W Kupiec-Weglinski, Elaine F Reed
Antibody-mediated rejection (AMR) resulting in transplant allograft vasculopathy (TAV) is the major obstacle for long-term survival of solid organ transplants. AMR is caused by donor-specific antibodies to HLA which contribute to TAV by initiating outside-in signaling transduction pathways that elicit monocyte recruitment to activated endothelium. Mechanistic target of rapamycin (mTOR) inhibitors can attenuate TAV; therefore, we sought to understand the mechanistic underpinnings of mTOR signaling in HLA class I Ab-mediated endothelial cell activation and monocyte recruitment...
October 17, 2017: American Journal of Transplantation
James O'Neill, Andrew J Hogarth, Ian Pearson, Hannah Law, Robert Bowes, Ananth Kidambi, Stephen Wheatcroft, U Mohanaraj Sivananthan, Muzahir H Tayebjee
BACKGROUND: The assessment of myocardial viability is crucial before percutaneous coronary intervention (PCI) is carried out to ensure that the patient will gain benefit. Trans-coronary pacing (TCP) has previously been used to pace myocardium but may also provide information on myocardial viability. METHODS: Patients with a single, significant coronary stenosis requiring PCI were recruited. They underwent a cardiac MRI to assess myocardial viability. Prior to PCI, a coronary guidewire was used to measure pacing threshold, impedance, and R-wave amplitude in different myocardial segments to determine any association between the electrical parameters and myocardial viability...
October 16, 2017: Catheterization and Cardiovascular Interventions
Melanie Love, Barry A Farber
This article uses both a case illustration and data from a large-scale survey of outpatient clients (N = 798) to understand the client's perspective about avoiding or being dishonest with his or her therapist about sexual topics. The case study, of a gay young man working with a heterosexual female therapist, explores this client's experience of what happens when it feels impossible to be forthcoming about sex and sexuality. Based on the findings of our study, we note clients' motives for avoiding these intimate yet important areas (e...
November 2017: Journal of Clinical Psychology
Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel-Gutfreund, Mehdi Khaled, Jacob H Hanna, Carmit Levy
Ectopic expression of lineage master regulators induces transdifferentiation. Whether cell fate transitions can be induced during various developmental stages has not been systemically examined. Here we discover that amongst different developmental stages, mouse embryonic stem cells (mESCs) are resistant to cell fate conversion induced by the melanocyte lineage master regulator MITF. By generating a transgenic system we exhibit that in mESCs, the pluripotency master regulator Oct4, counteracts pro-differentiation induced by Mitf by physical interference with MITF transcriptional activity...
October 18, 2017: Nature Communications
Carl A Shiffman
A retrospective analysis of the electrical impedances of 154 normal subjects measured over the past decade shows that "scaling" of the Nyquist plots for human thigh muscles is a property shared by healthy thigh musculature, irrespective of subject and the length of muscle segment. Here the term scaling signifies the near and sometimes "perfect" coalescence of the separate X vs R plots into one "reduced" Nyquist plot by the simple expedient of dividing R and X by Xm , the value of X at the reactance maximum...
October 18, 2017: Physiological Measurement
Tin Kang, Cheng-Min Tsai, Yu-He Jiang, Ganesh Gollavelli, Nayantara Mohanta, Eric Wei-Guang Diau, Chain-Shu Hsu
Two fullerene derivatives with styryl and oxetane cross-linking groups served as interfacial materials to modify an electron-transporting layer (ETL) of TiO2, doped with Au nanoparticles, processed under low-temperature conditions to improve the performance of perovskite solar cells (PSC). The cross-linkable [6, 6]-phenyl-C61-butyric styryl dendron ester (C-PCBSD) was produced via thermal treatment at 160 (○)C for 20 min while the cross-linkable [6, 6]-phenyl-C61-butyric oxetane dendron ester (C-PCBOD) was obtained via UV-curing treatment for 45 s...
October 18, 2017: ACS Applied Materials & Interfaces
Xiaolei Sun, Xueyi Lu, Shaozhuan Huang, Lixia Xi, Lixiang Liu, Bo Liu, Qunhong Weng, Lin Zhang, Oliver G Schmidt
Germanium is a promising anode material for lithium ion batteries because of its high theoretical specific capacity and low operation voltage. However, a significant challenge in using Ge-based anodes is the large volume variation during cycling that causes pulverization and capacity fade. Despite intense studies in the past decade, unsatisfactory cycling stability of the Ge-based electrodes still impedes their widespread applications. In this paper, we demonstrate a high performance electrode through the synergistic combination of a high-capacity Ge film grown on a three-dimensional current collector and an in-situ formed PVDF-HFP/SiO2 protective layer...
October 18, 2017: ACS Applied Materials & Interfaces
Kisu Lee, Jaehoon Ryu, Haejun Yu, Juyoung Yun, Jungsup Lee, Jyongsik Jang
We modified phenyl-C61-butyric acid methyl ester (PCBM) for use as a stable, efficient electron transport layer (ETL) in inverted perovskite solar cells (PSCs). PCBM containing a surfactant Triton X-100 acts as the ETL and NiOX nanocrystals act as a hole transport layer (HTL). Atomic force microscopy and scanning electron microscopy images showed that surfactant-modified PCBM (s-PCBM) forms a high-quality, uniform, and dense ETL on the rough perovskite layer. This layer effectively blocks holes and reduces interfacial recombination...
October 18, 2017: Nanoscale
Daoran Li, Baoshan Zhang, Wei Liu, Xiaohui Liang, Guangbin Ji
Proper impedance matching and strong attenuation capabilities are crucial factors for an excellent microwave absorbent. Significant attention and effort have been focused on the attenuation capabilities, whereas little attention has been paid to impedance matching, which is particularly important to design broadband absorbing materials. In this study, coin-like porous FeCo/C composites were successfully prepared by a simple carbon thermal reduction method. The Zin/Zo values of the FeCo/C composites were calculated to investigate the effects of the Fe/Co molar ratio and structure on the impedance matching...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Wei Zhao, Cheng Li, Aijian Wang, Cuncai Lv, Weihua Zhu, Shengping Dou, Qian Wang, Qin Zhong
Polyaniline (PANI)-decorated Bi2MoO6 nanosheets (BMO/PANI) were prepared by a facile solvothermal method. Different characterization techniques, including X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, diffuse reflectance ultraviolet-visible spectroscopy, photoluminescence spectroscopy, electrochemical impedance spectroscopy, photocurrent spectroscopy, and nanosecond time-resolved emission studies, have been employed to investigate the structure, optical and electrical properties of the BMO/PANI composites...
October 18, 2017: Physical Chemistry Chemical Physics: PCCP
Shoichiro Yamamoto, Seigo Miyoshi, Hitoshi Katayama, Mikio Okazaki, Hisayuki Shigematsu, Yoshifumi Sano, Minoru Matsubara, Naohiko Hamaguchi, Takafumi Okura, Jitsuo Higaki
PURPOSE: Spirometry is sometimes difficult to perform in elderly patients and in those with severe respiratory distress. The forced-oscillation technique (FOT) is a simple and noninvasive method of measuring respiratory impedance. The aim of this study was to determine if FOT data reflect spirometric indices. PATIENTS AND METHODS: Patients underwent both FOT and spirometry procedures prior to inclusion in development (n=1,089) and validation (n=552) studies. Multivariate linear regression analysis was performed to identify FOT parameters predictive of vital capacity (VC), forced VC (FVC), and forced expiratory volume in 1 second (FEV1)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
David Kinnamon, Ramesh Ghanta, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
A non-faradaic label-free cortisol biosensor was demonstrated using MoS2 nanosheets integrated into a nanoporous flexible electrode system. Low volume (1-5 μL) sensing was achieved through use of a novel sensor stack design comprised of vertically aligned metal electrodes confining semi-conductive MoS2 nanosheets. The MoS2 nanosheets were surface functionalized with cortisol antibodies towards developing an affinity biosensor specific to the physiological relevant range of cortisol (8.16 to 141.7 ng/mL) in perspired human sweat...
October 17, 2017: Scientific Reports
Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo
INTRODUCTION: Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. METHODS AND ANALYSIS: The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea...
October 16, 2017: BMJ Open
Xing Du, Feng Wang, Zhiwei Hu, Jimin Wu, Zhonggao Wang, Chao Yan, Chao Zhang, Juan Tang
BACKGROUND: None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS: Two hundred and fifty patients with symptoms suggestive of GERD and 35 asymptomatic healthy volunteers provided saliva on morning waking, after lunch and dinner for pepsin determination using the Peptest lateral flow device...
October 17, 2017: BMC Gastroenterology
Ying-Jia Li, Brian P Cahill
An electrowetting-on-dielectric (EWOD) electrode was developed that facilitates the use of low alternating voltages (≤ 5 VAC). This allows on-line investigation of the frequency dependence of electrowetting by means of impedance spectroscopy. The EWOD electrode is based on a dielectric bilayer consisting of an anodic tantalum pentoxide (Ta2O5) thin film (d = 59.35 nm) with a high relative permittivity (ε_d = 26.3) and a self-assembled hydrophobic silane monolayer. The frequency dependence of electrowetting was studied using an aqueous µL-sized sessile droplet on the planar EWOD electrode in oil...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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