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https://www.readbyqxmd.com/read/28650451/inability-to-work-and-need-for-disability-pension-among-long-term-survivors-of-hematopoietic-stem-cell-transplantation
#1
A Tichelli, S Gerull, A Holbro, A Buser, G Nair, M Medinger, D Heim, J P Halter, J R Passweg
Return to work is critical goal following HSCT. However, late effects may impede return to normal activity after HSCT. In the case of inability to work, patients may need a work disability pension to ensure a reasonable livelihood. This study evaluated inability to work and need for disability pension among long-term survivors and analyzed possible determinants of need for social support. This retrospective, single-center study included all HSCT patients surviving ⩾5 years seen at the outpatient clinic between January 2013 and August 2015...
June 26, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28650155/probing-interface-defects-in-top-gated-mos2-transistors-with-impedance-spectroscopy
#2
Peng Zhao, Angelica Azcatl, Yuri Y Gomeniuk, Pavel Bolshakov, Michael Schmidt, Stephen J McDonnell, Christopher L Hinkle, Paul K Hurley, Robert M Wallace, Chadwin Young
The electronic properties of the HfO2/MoS2 interface were investigated using multi-frequency capacitance-voltage (C-V) and current-voltage characterization of top gated MoS2 metal oxide semiconductor field effect transistors. The analysis was performed on few layer (5 - 10) MoS2 MOSFETs fabricated using photolithographic patterning with 13 nm and 8 nm HfO2 gate oxide layers formed by atomic layer deposition after in-situ UV-O3 surface functionalization. The impedance response of the HfO2/MoS2 gate stack indicates the existence of specific defects at the interface, which exhibited either a frequency dependent distortion similar to conventional Si MOSFETs with unpassivated silicon dangling bonds, or a frequency dispersion over the entire voltage range corresponding to depletion of the HfO2/MoS2 surface, consistent with interface traps distributed over a range of energy levels...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650138/photoelectrochemical-and-impedance-spectroscopic-analysis-of-amorphous-si-for-light-guided-electrodeposition-and-hydrogen-evolution-reaction
#3
Sung Yul Lim, Donghyeop Han, Yang-Rae Kim, Taek Dong Chung
For more efficient photoelectrochemical water splitting, there is a dilemma that a photoelectrode needs both light absorption and electrocatalytic faradaic reaction. One of the promising strategies is to deposit a pattern of electrocatalysts onto a semiconductor surface; leaving sufficient bare surface for light absorption, while minimizing concentration overpotential as well as resistive loss at the ultramicroelectrodes for faradaic reaction. This scheme can be successfully realized by "maskless" direct photoelectrochemical patterning of electrocatalyst onto an SiOx/amorphous Si (a-Si) surface by light-guided electrodeposition technique...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650005/sub-picomolar-label-free-detection-of-thrombin-using-electrochemical-impedance-spectroscopy-of-aptamer-functionalized-mos2
#4
Kai-Chun Lin, Badrinath Jagannath, Sriram Muthukumar, Shalini Prasad
An ultrasensitive aptasensor for the label free non-faradaic detection of thrombin has been demonstrated on molybdenum disulphide (MoS2) nanosheets. These nanosheets were physiochemically immobilized onto a silicon micro-electrode platform. Thrombin detection was achieved through the charge modulation of the electrical double layer due to the specific and dose dependent binding of thrombin to the surface of thiol terminated ssDNA aptamer functionalized MoS2 nanosheets. Electrical double layer charge modulation associated with thrombin binding was characterized using electrochemical impedance spectroscopy...
June 26, 2017: Analyst
https://www.readbyqxmd.com/read/28649928/beyond-the-medical-model
#5
Scott J Fitzpatrick, Jo River
The medical model continues to dominate research and shape policy and service responses to suicide. In this work we challenge the assumption that the medical model always provides the most effective and appropriate care for persons who are suicidal. In particular, we point to service user perspectives of health services which show that interventions are often experienced as discriminatory, culturally inappropriate, and incongruent with the needs and values of persons who are suicidal. We then examine "humanistic" approaches to care that have been proposed as a corrective to an overly medical model...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28649771/evaluation-of-the-sysmex-xn-550-a-novel-compact-haematology-analyser-from-the-xn-l-%C3%A2-series-compared-to-the-xn-20-system
#6
H Tailor, I Mackie, A Mellick, S Machin
INTRODUCTION: The XN-550 is a new, automated, compact, haematology analyser designed to generate a full blood count with a standard five-part white blood cell differential and an immature granulocyte count, as well as an optional reticulocyte and optical platelet (PLT) counts. The aim of the study was to evaluate the performance of the XN-550 and compare it to the established XN-20 system. METHODS: We evaluated the basic parameter and special measurement channels of the XN-550, using the XN-20 (which has a similar operating system), as a reference analyser...
June 25, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28649730/novel-contrast-enhanced-ultrasound-evaluation-in-neonatal-hypoxic-ischemic-injury-clinical-application-and-future-directions
#7
Misun Hwang, Robert M De Jong, Stephan Herman, Renee Boss, Becky Riggs, Aylin Tekes-Brady, Melissa Spevak, Andrea Poretti, Bruno P Soares, Christopher R Bailey, Emily Dunn, Samuel S Shin, Shai Shrot, Thierry A G M Huisman
Sensitive, specific, and safe bedside evaluation of brain perfusion is key to the early diagnosis, treatment, and improved survival of neonates with hypoxic ischemic injury. Contrast-enhanced ultrasound (US) imaging is a novel imaging technique in which intravenously injected gas-filled microbubbles generate enhanced US echoes from an acoustic impedance mismatch. This article describes contrast-enhanced US imaging in 2 neonates with hypoxic ischemic injury and future directions on developing quantitative contrast-enhanced US techniques for improved characterization of perfusion abnormalities...
June 26, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28649423/ubiquitous-overexpression-of-the-dna-repair-factor-dprp19-reduces-dna-damage-and-extends-drosophila-life-span
#8
Kathrin Garschall, Hanna Dellago, Martina Gáliková, Markus Schosserer, Thomas Flatt, Johannes Grillari
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the accumulation of somatic mutations, which is thought to be one of the major causes of aging. We have previously found that overexpression of the essential human DNA repair and splicing factor SNEV, also called PRP19 or hPso4, extends replicative life span of cultured human endothelial cells and impedes accumulation of DNA damage...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28649088/targeting-aggf1-angiogenic-factor-with-g-patch-and-fha-domains-1-for-blocking-neointimal-formation-after-vascular-injury
#9
Yufeng Yao, Zhenkun Hu, Jian Ye, Changqing Hu, Qixue Song, Xingwen Da, Yubin Yu, Hui Li, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang
BACKGROUND: Despite recent improvements in angioplasty and placement of drug-eluting stents in treatment of atherosclerosis, restenosis and in-stent thrombosis impede treatment efficacy and cause numerous deaths. Research efforts are needed to identify new molecular targets for blocking restenosis. We aim to establish angiogenic factor AGGF1 (angiogenic factor with G patch and FHA domains 1) as a novel target for blocking neointimal formation and restenosis after vascular injury. METHODS AND RESULTS: AGGF1 shows strong expression in carotid arteries; however, its expression is markedly decreased in arteries after vascular injury...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28649010/mussels-do-not-directly-assimilate-fish-farm-wastes-shifting-the-rationale-of-integrated-multi-trophic-aquaculture-to-a-broader-scale
#10
Carlos Sanz-Lazaro, Pablo Sanchez-Jerez
Pollution is one of the most significant issues that is currently impeding the development of fish farming. Integrated multi-trophic aquaculture (IMTA) has the potential to reduce the accumulation of organic wastes in the environment by using taxa of lower trophic levels such as filter feeders. However, the capacity of filter feeders to assimilate significant quantities of fish farm wastes has not yet been fully tested in situ. We analyzed the stable isotopes δ(13)C and δ(15)N in mussels from six fish farms and from six other areas that were not influenced by fish farming, at two water strata (surface and mid-water) across a marked gradient of eutrophication along more than 900 km of coastline in the Western Mediterranean...
June 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28648940/upregulation-of-inhibitory-signaling-receptor-programmed-death-marker-1-pd-1-in-disease-evolution-from-cutaneous-lymphoid-dyscrasias-to-mycosis-fungoides-and-sezary-s-syndrome
#11
Giang Huong Nguyen, Luke C Olson, Cynthia M Magro
BACKGROUND: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. DESIGN: In this study, skin biopsies from 42 prelymphomatous T-cell dyscrasias (CLD), 9 Sezary's syndrome (SS), 103 MF, and 20 CD30+ lymphoproliferative diseases (LPD) were examined for PD-1 expression using immunohistochemistry...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28648316/exploring-product-specific-attributes-of-a-community-cardiac-rehabilitation-program-in-an-asian-urban-city
#12
Yu Heng Kwan, Angela Frances Yap, Hung Yong Tay, Cindy Lim, Sui Yung Chan, Warren Fong
BACKGROUND: Cardiac rehabilitation (CR) has been proven to improve long-term outcomes for patients. Despite its benefits, its uptake throughout the world is poor. Factors affecting the motivation and barriers impeding an individual from participating in a CR program have been extensively studied. Nevertheless, knowledge of product-specific factors in affecting participation is lacking. OBJECTIVES: To find out cultural-specific product attributes that are important to those contemplating participation in a community-based CR program using Consolidated criteria for Reporting Qualitative research (COREQ) as an anchor...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28648074/boronic-acid-functionalized-oxide-free-silicon-surfaces-for-the-electrochemical-sensing-of-dopamine
#13
Bruno Fabre, Fanny Hauquier
Boronic acid monolayers covalently bound to hydrogen-terminated Si(111) surfaces have been prepared from the UV-directed hydrosilylation reaction of 4-vinylbenzeneboronic acid. X-ray photoelectron spectroscopy (XPS) analysis of the modified surface revealed characteristics peaks from the attached organic molecule with the expected molecular composition and without oxidation of underlying silicon. From XPS data, the surface coverage was estimated to be ca. 0.34 ± 0.04 ethylbenzene boronic acid chain per surface silicon atom (i...
June 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28647856/glial-and-neuronal-protein-tyrosine-phosphatase-alpha-ptp%C3%AE-regulate-oligodendrocyte-differentiation-and-myelination
#14
Yuda Shih, Philip T T Ly, Jing Wang, Catherine J Pallen
CNS myelination defects occur in mice deficient in receptor-like protein tyrosine phosphatase alpha (PTPα). Here, we investigated the role of PTPα in oligodendrocyte differentiation and myelination using cells and tissues from wild-type (WT) and PTPα knockout (KO) mice. PTPα promoted the timely differentiation of neural stem cell-derived oligodendrocyte progenitor cells (OPCs). Compared to WT OPCs, KO OPC cultures had more NG2+ progenitors, fewer myelin basic protein (MBP)+ oligodendrocytes, and reduced morphological complexity...
June 24, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28647265/evaluation-of-co-metabolic-removal-of-trichloroethylene-in-a-biotrickling-filter-under-acidic-conditions
#15
Dhawal Chheda, George A Sorial
This study investigated the removal of hydrophobic trichloroethylene (TCE) in the presence of methanol (co-metabolite) in a biotrickling filter, which was seeded with fungi at pH4. Starvation was chosen as the biomass control strategy. Two systems, Biofilter I (methanol:TCE 70:30) and Biofilter II (methanol:TCE 80:20) were run in parallel, each with varying composition ratios. The TCE loading rates for both biofilters ranged from 3.22 to 12.88g/m(3)/hr. Depending on the ratio, methanol concentrations varied from 4...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647181/rosmarinic-acid-attenuates-hepatic-fibrogenesis-via-suppression-of-hepatic-stellate-cell-activation-proliferation-and-induction-of-apoptosis
#16
Naglaa M El-Lakkany, Walaa H El-Maadawy, Sayed H Seif El-Din, Olfat A Hammam, Salwa H Mohamed, Shahira M Ezzat, Marwa M Safar, Samira Saleh
OBJECTIVE: To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. METHODS: The impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was assessed along with its safety on primary hepatocytes. In vivo, rats were divided into: (i) normal; (ii) thioacetamide (TAA)-intoxicated rats for 12 weeks; (iii) TAA + silymarin or (iv) TAA + RA...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28646175/ribosome-rna-profiling-to-quantify-ovarian-development-and-identify-sex-in-fish
#17
Zhi-Gang Shen, Hong Yao, Liang Guo, Xiao-Xia Li, Han-Ping Wang
Terminologies of ovary development, by somewhat subjective describing and naming main changes of oocytes, have been criticized for confusing and inconsistency of terms and classifications, and the incurred consequences impede communication among researchers. In the present work, we developed regression between ovary development and three ribosome RNA (rRNA) indexes, namely 5S rRNA percent, 18S rRNA percent, and 5S-18S rRNA ratio, using close relationship between volume percent of primary growth stage oocytes or gonadosomatic index and rRNA content, demonstrating species-specific quantification of ovary development can be established in species with either synchronous and asynchronous oogenesis...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645869/real-time-changes-in-brain-activity-during-sacral-neuromodulation-for-overactive-bladder
#18
Bradley C Gill, Javier Pizarro Berdichevsky, Pallab K Bhattacharyya, Thaddeus S Brink, Brian K Marks, Adrienne Quirouet, Sandip P Vasavada, Stephen E Jones, Howard B Goldman
PURPOSE: To use functional magnetic resonance imaging(fMRI) for identifying changes in brain activity during sacral neuromodulation(SNM) in women with overactive bladder(OAB) who were responsive to therapy. MATERIALS AND METHODS: Women with non-neurogenic refractory OAB who responded to SNM, had a stable program for at least 3 months, with no subsequent OAB treatment were recruited. Enrolled patients completed pre-fMRI validated symptom and quality of life instruments...
June 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28645279/diabetes-care-in-a-complex-humanitarian-emergency-setting-a-qualitative-evaluation
#19
Adrianna Murphy, Michel Biringanine, Bayard Roberts, Beverley Stringer, Pablo Perel, Kiran Jobanputra
BACKGROUND: Evidence is urgently needed from complex emergency settings to support efforts to respond to the increasing burden of diabetes mellitus (DM). We conducted a qualitative study of a new model of DM health care (Integrated Diabetic Clinic within an Outpatient Department [IDC-OPD]) implemented by Médecins Sans Frontières (MSF) in Mweso Hospital in eastern Democratic Republic of Congo (DRC). We aimed to explore patient and provider perspectives on the model in order to identify factors that may support or impede it...
June 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28645263/microbiota-dependent-metabolite-and-cardiovascular-disease-marker-trimethylamine-n-oxide-tmao-is-associated-with-monocyte-activation-but-not-platelet-function-in-untreated-hiv-infection
#20
Judith M Haissman, Anna K Haugaard, Sisse R Ostrowski, Rolf K Berge, Johannes R Hov, Marius Trøseid, Susanne D Nielsen
BACKGROUND: HIV infection is associated with increased risk of cardiovascular disease beyond that explained by traditional risk factors. Altered gut microbiota, microbial translocation, and immune activation have been proposed as potential triggers. The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) predicts myocardial infarction (MI) in the general population and has recently been shown to induce platelet hyperreactivity. In the present study, we investigated if TMAO was associated with platelet function, microbial translocation, and immune activation in both untreated and combination anti-retroviral therapy (cART) HIV infection...
June 23, 2017: BMC Infectious Diseases
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