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https://www.readbyqxmd.com/read/28102195/positive-association-between-kcnj5-rs2604204-a-c-polymorphism-and-plasma-aldosterone-levels-but-also-plasma-renin-and-angiotensin-i-and-ii-levels-in-newly-diagnosed-hypertensive-chinese-a-case-control-study
#1
H Wang, C Weng, H Chen
Variants in G protein-coupled inward rectifier K(+) channels 4 (GIRK4 also known as KCNJ5) gene are associated with primary aldosteronism, which is the most common cause of secondary hypertension. The KCNJ5 rs2604204 variant was shown to be common (minor allele frequency=32.5%) in Chinese patients with essential hypertension (EH). The relationship between KCNJ5 variant and plasma aldosterone (ALD) levels in EH patients has not been reported. We collected 229 patients with newly diagnosed EH without any antihypertensive agents...
January 19, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28102030/impact-of-sodium-glucose-cotransporter-2-inhibitors-on-nonglycemic-outcomes-in-patients-with-type-2-diabetes
#2
Jennifer M Trujillo, Wesley A Nuffer
The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body weight and blood pressure, which may confer additional health benefits. SGLT2 inhibitors are also associated with evidence of renal-protecting benefits. Furthermore, during the landmark Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME) trial, a substantial reduction in major adverse cardiovascular outcomes was demonstrated with empagliflozin therapy...
January 19, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28101752/the-impact-of-hydrocortisone-treatment-on-neutrophil-gelatinase-associated-lipocalin-release-in-porcine-endotoxemic-shock
#3
E Söderberg, M Eriksson, A Larsson, M Lipcsey
BACKGROUND: A key feature of sepsis is systemic inflammatory activation that could be counteracted by steroids. In this experimental model of systemic inflammation, we sought to investigate whether septic neutrophil activation, evaluated by the plasma levels of neutrophil gelatinase-associated protein (NGAL), is modulated by the timing of hydrocortisone treatment. METHODS: Sixteen anesthetized pigs were allocated to one of four equally sized groups. Three of these groups received endotoxin at 2 μg × kg(-1) × h(-1) for 6 h so as to induce endotoxemic shock...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28100183/short-term-blood-pressure-variability-variation-between-arm-side-body-position-and-successive-measurements-a-population-based-cohort-study
#4
Maria Elena Lacruz, Alexander Kluttig, Oliver Kuss, Daniel Tiller, Daniel Medenwald, Sebastian Nuding, Karin Halina Greiser, Stefan Frantz, Johannes Haerting
BACKGROUND: Precise blood pressure (BP) measurements are central for the diagnosis of hypertension in clinical and epidemiological studies. The purpose of this study was to quantify the variability in BP associated with arm side, body position, and successive measurements in the setting of a population-based observational study. Additionally, we aimed to evaluate the influence of different measurement conditions on prevalence of hypertension. METHODS: The sample included 967 men and 812 women aged 45 to 83 years at baseline...
January 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28099662/effects-of-neighborhood-socioeconomic-status-on-blood-pressure-in-older-adults
#5
Katia Jakovljevic Pudla Wagner, Antonio Fernando Boing, S V Subramanian, Doroteia Aparecida Höfelmann, Eleonora D'Orsi
OBJECTIVE: To test if the neighborhood socioeconomic status is associated with systolic blood pressure and hypertension in older adults. METHODS: A cross-sectional population-based study with a sample of 1,705 older adults from Florianópolis, SC, Southern Brazil. The contextual variable used was the average years of schooling of the head of the household in census tracts. Participants were considered hypertensive when the systolic blood pressure was ≥ 140 mmHg, diastolic ≥ 90 mmHg, or both...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099586/serotoninergic-modulation-of-basal-cardiovascular-responses-and-responses-induced-by-isotonic-extracellular-volume-expansion-in-rats
#6
Isadora Ferraz Semionatto, Adrieli Oliveira Raminelli, Angelica Cristina Alves, Caroline Santos Capitelli, Rosangela Soares Chriguer
Background: Isotonic blood volume expansion (BVE) induced alterations of sympathetic and parasympathetic activity in the heart and blood vessels, which can be modulated by serotonergic pathways. Objective: To evaluate the effect of saline or serotonergic agonist (DOI) administration in the hypothalamic paraventricular nucleus (PVN) on cardiovascular responses after BVE. Methods: We recorded pulsatile blood pressure through the femoral artery to obtain the mean arterial pressure (MAP), systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and the sympathetic-vagal ratio (LF/HF) of Wistar rats before and after they received bilateral microinjections of saline or DOI into the PVN, followed by BVE...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28099159/reducing-false-arrhythmia-alarm-rates-using-robust-heart-rate-estimation-and-cost-sensitive-support-vector-machines
#7
Qiang Zhang, Xianxiang Chen, Zhen Fang, Qingyuan Zhan, Ting Yang, Shanhong Xia
To lessen the rate of false critical arrhythmia alarms, we used robust heart rate estimation and cost-sensitive support vector machines. The PhysioNet MIMIC II database and the 2015 PhysioNet/CinC Challenge public database were used as the training dataset; the 2015 Challenge hidden dataset was for testing. Each record had an alarm labeled with asystole, extreme bradycardia, extreme tachycardia, ventricular tachycardia or ventricular flutter/fibrillation. Before alarm onsets, 300 s multimodal data was provided, including electrocardiogram, arterial blood pressure and/or photoplethysmogram...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098771/breast-cancer-brain-metastases-clonal-evolution-in-clinical-context
#8
REVIEW
Jodi M Saunus, Amy E McCart Reed, Zhun Leong Lim, Sunil R Lakhani
Brain metastases are highly-evolved manifestations of breast cancer arising in a unique microenvironment, giving them exceptional adaptability in the face of new extrinsic pressures. The incidence is rising in line with population ageing, and use of newer therapies that stabilise metastatic disease burden with variable efficacy throughout the body. Historically, there has been a widely-held view that brain metastases do not respond to circulating therapeutics because the blood-brain-barrier (BBB) restricts their uptake...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098511/hemodynamic-effects-of-hpma-copolymer-based-doxorubicin-conjugate-a-randomized-controlled-and-comparative-spectral-study-in-conscious-rats
#9
Hoay Yan Cheah, Olivera Šarenac, Juan J Arroyo, Marko Vasić, Maja Lozić, Sofija Glumac, See Ziau Hoe, Charles Colin Thomas Hindmarch, David Murphy, Lik Voon Kiew, Hong Boon Lee, Marίa J Vicent, Lip Yong Chung, Nina Japundžić-Žigon
Conjugation of Doxorubicin (DOX) to N-(2-Hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX...
January 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28097669/mathematical-modeling-of-rotary-blood-pumps-in-a-pulsatile-in-vitro-flow-environment
#10
Tohid Pirbodaghi
Nowadays, sacrificing animals to develop medical devices and receive regulatory approval has become more common, which increases ethical concerns. Although in vivo tests are necessary for development and evaluation of new devices, nonetheless, with appropriate in vitro setups and mathematical models, a part of the validation process can be performed using these models to reduce the number of sacrificed animals. The main aim of this study is to present a mathematical model simulating the hydrodynamic function of a rotary blood pump (RBP) in a pulsatile in vitro flow environment...
January 18, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28097295/association-of-systemic-medication-use-with-intraocular-pressure-in-a-multiethnic-asian-population-the-singapore-epidemiology-of-eye-diseases-study
#11
Henrietta Ho, Yuan Shi, Jacqueline Chua, Yih-Chung Tham, Sing Hui Lim, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
Importance: There is limited understanding of the associations between systemic medication use and intraocular pressure (IOP) in the general population. Objective: To examine the association between systemic medication use and IOP in a multiethnic Asian population. Design, Setting, and Participants: In this post hoc analysis of the Singapore Epidemiology of Eye Diseases study, a population-based study of 10 033 participants (78.7% response rate) from 3 racial/ethnic groups (Chinese [recruited from February 9, 2009, through December 19, 2011], Malays [recruited from August 16, 2004, though July 10, 2006], and Indians [recruited from May 21, 2007, through December 29, 2009]), participants with glaucoma, previous ocular surgery, or trauma and an IOP asymmetry greater than 5 mm Hg between eyes were excluded...
January 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28097106/postmeal-triglyceridemia-and-variability-of-hba1c-and-postmeal-glycemia-were-predictors-of-annual-decline-in-estimated-glomerular-filtration-rate-in-type-2-diabetic-patients-with-different-stages-of-nephropathy
#12
Ayaka Tsuboi, Akiko Takenouchi, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: This study examined associations of annual glycemic variability and postprandial dysmetabolism with annual decline in estimated glomerular filtration rate (eGFR) in type 2 diabetic patients with different stages of nephropathy. METHODS: Intrapersonal mean and coefficient of variation (CV) of HbA1c, fasting and postmeal concentrations of plasma glucose (FPG and PMPG, respectively) and serum triglycerides (FTG and PMTG, respectively) during the first 12 months after enrollment were calculated in a cohort of 168 type 2 diabetic patients: 53 with optimal albumin/creatinine ratio (ACR < 10 mg/g), 62 with high normal ACR (10-29 mg/g) and 53 with elevated ACR (≧30 mg/g)...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28097009/statin-utilisation-in-a-real-world-setting-a-retrospective-analysis-in-relation-to-arterial-and-cardiovascular-autonomic-function
#13
John D Sluyter, Alun D Hughes, Andrew Lowe, Carlos A Camargo, Robert K R Scragg
Randomized trials suggest that statin treatment may lower blood pressure and influence cardiovascular autonomic function (CVAF), but the impact of duration of usage, discontinuation, and adherence to this therapy is unknown. We examined these issues with regard to blood pressure (BP)-related variables in a large, population-based study. Participants were 4942 adults (58% male; aged 50-84 years): 2179 on statin treatment and 2763 untreated. Days of utilization, adherence (proportion of days covered ≥0.8), and discontinuation (non-use for ≥30 days immediately prior to BP measurement) of three statins (atorvastatin, pravastatin, and simvastatin) over a period of up to 2 years was monitored retrospectively from electronic databases...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28096150/hemodynamic-determinants-of-the-short-term-blood-pressure-variability-differential-roles-of-arterial-stiffness-and-wave-reflection
#14
Pai-Feng Hsu, Hao-Min Cheng, Shih-Hsien Sung, Shao-Yuan Chuang, Edward G Lakatta, Frank C P Yin, Pesus Chou, Chen-Huan Chen
BACKGROUND: A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. The present study was aimed to investigate hemodynamic factors that are independently associated with systolic and diastolic BPV from the 24-hour ambulatory blood pressure monitoring (ABPM). METHODS: A cohort of 624 normotensive and 633 untreated hypertensive participants with baseline ABPM was drawn from a community-based survey...
January 17, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28095501/birth-weight-and-its-relationship-with-the-cardiac-autonomic-balance-in-healthy-children
#15
Livia Victorino Souza, Vanessa Oliveira, Franciele De Meneck, Ana Paula Grotti Clemente, Maria Wany Louzada Strufaldi, Maria do Carmo Franco
Several studies indicate that the fetal environment plays a significant role in the development of cardiometabolic disease later in life. However, a few studies present conflicting data about the correlation between birth weight and the impairment of cardiac autonomic modulation. The purpose of the present study was to provide further knowledge to elucidate this contradictory relationship. One hundred children aged 5 and 14 years had anthropometric parameters, body composition and blood pressure levels determined...
2017: PloS One
https://www.readbyqxmd.com/read/28094030/glucocorticoid-induced-leucine-zipper-protein-regulates-sodium-and-potassium-balance-in-the-distal-nephron
#16
Priyanka Rashmi, GianLuca Colussi, Michael Ng, Xinhao Wu, Atif Kidwai, David Pearce
Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence supporting a role for GILZ in modulating the balance of renal sodium and potassium excretion by regulating the sodium-chloride cotransporter (NCC) activity in the distal nephron. Gilz(-/-) mice have a higher plasma potassium concentration and lower fractional excretion of potassium than wild type mice...
January 13, 2017: Kidney International
https://www.readbyqxmd.com/read/28093412/beyond-bernoulli-improving-the-accuracy-and-precision-of-noninvasive-estimation-of-peak-pressure-drops
#17
Fabrizio Donati, Saul Myerson, Malenka M Bissell, Nicolas P Smith, Stefan Neubauer, Mark J Monaghan, David A Nordsletten, Pablo Lamata
BACKGROUND: Transvalvular peak pressure drops are routinely assessed noninvasively by echocardiography using the Bernoulli principle. However, the Bernoulli principle relies on several approximations that may not be appropriate, including that the majority of the pressure drop is because of the spatial acceleration of the blood flow, and the ejection jet is a single streamline (single peak velocity value). METHODS AND RESULTS: We assessed the accuracy of the Bernoulli principle to estimate the peak pressure drop at the aortic valve using 3-dimensional cardiovascular magnetic resonance flow data in 32 subjects...
January 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28093005/cardiac-and-respiratory-effects-of-deep-regional-hyperthermia-using-an-8-mhz-radiofrequency-capacitive-device-on-patients-with-cancer
#18
Rieko Izukura, Hajime Imada, Nobuko Hashiguchi, Hiroyuki Sawatari, Takayuki Ohguri, Mami Miyazono, Shin Ohta, Chizuko Takakura, Keiko Yamasaki, Chie Magota, Kanae Fujita, Hiromi Kuroda, Hideki Hirata, Tomoko Ohkusa, Akiko Chishaki
PURPOSE: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. MATERIALS AND METHODS: Thirty-one patients (age: 61±12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min...
January 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28092245/-effect-of-the-diabetimss-program-on-cardiovascular-risk-blood-pressure-and-hdl-cholesterol-in-patients-with-metabolic-syndrome
#19
Miguel Angel Mendoza-Romo, Juan Felipe Montes-Acuña, Gad Gamed Zavala-Cruz, Rafael Natividad Nieva-de Jesús, María Cleofas Ramírez-Arreola, Héctor Jesús Andrade-Rodríguez
OBJECTIVE: The aim of this paper is to evaluate the effect of the DiabetIMSS program on cardiovascular risk, blood pressure and HDL cholesterol in patients with metabolic syndrome. METHODS: Quasi-experimental intervention study. Non-probabilistic convenience sampling. 35 subjects in the educational strategy one year were included. The following variables were collected: age, gender, smoking, total cholesterol, HDL cholesterol, systolic and diastolic blood pressure; cardiovascular risk calculator based on Framingham is calculated...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28089902/olmesartan-with-azelnidipine-versus-with-trichlormethiazide-on-home-blood-pressure-variability-in-patients-with-type-ii-diabetes-mellitus
#20
Emi Ushigome, Shinobu Matsumoto, Chikako Oyabu, Hidetaka Ushigome, Isao Yokota, Goji Hasegawa, Naoto Nakamura, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
The aim of the present study was to compare the effects of olmesartan combined with azelnidipine versus olmesartan combined with trichlormethiazide, on home blood pressure (BP) and pressure variability in type II diabetes mellitus patients using home BP telemonitoring system. We performed an open-label cross-over pilot study of 28 patients with type II diabetes mellitus. Patients received combination treatment with either olmesartan 20 mg plus azelnidipine 16 mg or olmesartan 20 mg plus trichlormethiazide 1 mg for more than 6 weeks each in a cross-over method...
December 22, 2016: Journal of the American Society of Hypertension: JASH
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