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https://www.readbyqxmd.com/read/29668880/restraint-induced-crh-elevation-triggers-apoptosis-of-ovarian-cells-and-impairs-oocyte-competence-via-activation-of-the-fas-fasl-system
#1
Chuan-Yong Li, Zhi-Bin Li, Qiao-Qiao Kong, Xiao Han, Bin Xiao, Xiao Li, Zhong-Le Chang, Jing-He Tan
Mechanisms by which psychological stress damages oocytes are largely undetermined. Although a previous study showed that the stress-induced corticotrophin-releasing hormone (CRH) elevation impaired oocyte competence by triggering apoptosis of ovarian cells, how CRH causes apoptosis in ovarian cells and oocytes is unknown. In this study, we have examined the hypothesis that restraint stress (RS)-induced CRH elevation triggers apoptosis of ovarian cells and impairs oocyte competence through activating the Fas/FasL system...
April 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29663559/sex-differences-in-hippocampal-mineralocorticoid-and-glucocorticoid-receptor-mrna-expression-in-response-to-acute-mate-pair-separation-in-zebra-finches-taeniopygia-guttata
#2
Farrah N Madison, Andrew J Kesner, Beau A Alward, Gregory F Ball
Mate separation has been shown to mediate changes in physiological and behavioral processes via activation of the hypothalamo-pituitary-adrenal (HPA) axis in both mammalian and avian species. In order to elucidate the neural mechanisms associated with changes in the HPA axis in response to social stress, we investigated the effects of mate pair separation on circulating corticosterone concentrations as well as gene expression levels of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), and corticotropin releasing hormone (CRH) in the hypothalamus and hippocampus of both male and female zebra finches, a species that forms strong pair bonds...
April 16, 2018: Hippocampus
https://www.readbyqxmd.com/read/29658387/identification-of-avian-vasotocin-receptor-subtype-specific-antagonists-involved-in-the-stress-response-of-the-chicken-gallus-gallus
#3
Seong W Kang, Srinivas Jayanthi, Gurueswar Nagarajan, Thallapuranam Krishnaswamy Suresh Kumar, Wayne J Kuenzel
Vasotocin 1a and 1b receptors (V1aR and V1bR) have been shown to play important roles in the neuroendocrine regulation of stress responses via the anterior pituitary (AP) of birds. To identify effective subtype-specific antagonists for the chicken V1aR (cV1aR) and cV1bR, potential antagonists to the mammalian V1R were screened against the cV1aR and cV1bR 3D structural models by molecular docking analysis with determination of binding pocket / amino acid residues involved in the interaction. The antagonistic effects of the selected ligands were examined by measuring pro-opiomelanocortin (POMC) heteronuclear RNA (hnPOMC) levels following the in vitro stress administration to primary chicken AP cells...
April 16, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29642854/comparative-transcriptome-analysis-of-hypothalamus-regulated-feed-intake-induced-by-exogenous-visfatin-in-chicks
#4
Zhuanjian Li, Xuelian Liu, Panpan Zhang, Ruili Han, Guirong Sun, Ruirui Jiang, Yanbin Wang, Xiaojun Liu, Wenya Li, Xiangtao Kang, Yadong Tian
BACKGROUND: The intracerebroventricular injection of visfatin increases feed intake. However, little is known about the molecular mechanism in chicks. This study was conducted to assess the effect of visfatin on the feeding behavior of chicks and the associated molecular mechanism. RESULTS: In response to the intraventricular injection of 40 ng and 400 ng visfatin, feed intake in chicks was significantly increased, and the concentrations of glucose, insulin, TG, HDL and LDL were significantly altered...
April 11, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29623778/involvement-of-dopamine-system-in-the-regulation-of-the-brain-corticotropin-releasing-hormone-in-paraventricular-nucleus-in-a-rat-model-of-chronic-visceral-pain
#5
Ning-Ning Ji, Jie Kang, Rong Hua, Yong-Mei Zhang
Objective We aimed to investigate the mechanism of paraventricular nucleus (PVN) and ventral tegmental area (VTA) circuit in the pathogenesis of visceral pain-depression with a rat model induced by neonatal and adult colorectal distension (CRD). Methods Neonate male Sprague-Dayley (SD) rats underwent CRD on postnatal days 8, 10, and 12, and when matured, were tested for adult abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity. The forced swimming test was employed to evaluate depression-like behaviors...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29609111/regulation-of-anxiety-like-behavior-and-crhr1-expression-in-the-basolateral-amygdala-by-lmo3
#6
Antonia Savarese, Amy W Lasek
The LIM domain only protein LMO3 is a transcriptional regulator that has been shown to regulate several behavioral responses to alcohol. Specifically, Lmo3 null (Lmo3Z ) mice consume more ethanol in a binge-drinking test and show enhanced ethanol-induced sedation. Due to the high comorbidity of alcohol use and anxiety, we investigated anxiety-like behavior in Lmo3Z mice. Lmo3Z mice spent more time in the open arms of the elevated plus maze compared with their wild-type littermates, but the effect was confounded by reduced locomotor activity...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29601583/chronic-restraint-stress-induces-excessive-activation-of-primordial-follicles-in-mice-ovaries
#7
Minhua Xu, Junyan Sun, Qian Wang, Qiuwan Zhang, Chunsheng Wei, Dongmei Lai
Chronic stress is an important factor influencing people's health. It usually causes endocrinal disorders and a decline in reproduction in females. Although studies of both human and animals suggest a detrimental effect of stress on reproduction, the influence of chronic stress on the ovarian reservation and follicular development is still not clear. In this study, a chronic restraint stress (CRS) mouse model was used to investigate the effect of stress on ovarian reservation and follicular development and explore the underlying mechanism...
2018: PloS One
https://www.readbyqxmd.com/read/29593501/chronic-stress-reduces-nectin-1-mrna-levels-and-disrupts-dendritic-spine-plasticity-in-the-adult-mouse-perirhinal-cortex
#8
Qian Gong, Yun-Ai Su, Chen Wu, Tian-Mei Si, Jan M Deussing, Mathias V Schmidt, Xiao-Dong Wang
In adulthood, chronic exposure to stressful experiences disrupts synaptic plasticity and cognitive function. Previous studies have shown that perirhinal cortex-dependent object recognition memory is impaired by chronic stress. However, the stress effects on molecular expression and structural plasticity in the perirhinal cortex remain unclear. In this study, we applied the chronic social defeat stress (CSDS) paradigm and measured the mRNA levels of nectin-1, nectin-3 and neurexin-1, three synaptic cell adhesion molecules (CAMs) implicated in the adverse stress effects, in the perirhinal cortex of wild-type (WT) and conditional forebrain corticotropin-releasing hormone receptor 1 conditional knockout (CRHR1-CKO) mice...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29576798/jinkui-shenqi-pills-ameliorate-asthma-with-kidney-yang-deficiency-by-enhancing-the-function-of-the-hypothalamic-pituitary-adrenal-axis-to-regulate-t-helper-1-2-imbalance
#9
Bing Ji, Yuan-Yuan Li, Wei-Ji Yang, Li-Zong Zhang, Ming-Sun Fang, Hui-Ying Fu, Qi-Yang Shou
The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods . Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered to OVA-challenged rats, and the changes in signs and symptoms of KYD were observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid (BALF) were counted and the cells were stained with Wright-Giemsa dye...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29576599/new-diagnostic-criteria-of-adrenal-subclinical-cushing-s-syndrome-opinion-from-the-japan-endocrine-society
#10
Toshihiko Yanase, Yutaka Oki, Takuyuki Katabami, Michio Otsuki, Kazunori Kageyama, Tomoaki Tanaka, Hisaya Kawate, Makito Tanabe, Masaru Doi, Yuko Akehi, Takamasa Ichijo
New diagnostic criteria and the treatment policy for adrenal subclinical Cushing's syndrome (SCS) are proposed on behalf of the Japan Endocrine Society. The Japanese version has been published, and the essential contents are presented in this English-language version. The current diagnostic criteria for SCS have elicited two main problems: (i) the relatively low reliability of a low range of serum cortisol essential for the diagnosis by an overnight 1-mg dexamethasone suppression test (DST); (ii) different cutoff values for serum cortisol after a 1-mg DST compared with those of other countries...
March 23, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29574263/evaluation-of-joint-effects-of-cyprodinil-and-kresoxim-methyl-on-zebrafish-danio-rerio
#11
Yanhua Wang, Dejiang Dai, Yijun Yu, Guiling Yang, Weifeng Shen, Qiang Wang, Hongbiao Weng, Xueping Zhao
Aquatic organisms are usually exposed to a mixture of pesticides instead of individual chemicals. However, risk assessment of pesticides is traditionally based on toxicity data of individual compounds. In this study, we aimed to examine the joint toxicity of two fungicides cyprodinil (CYP) and kresoxim-methyl (KRM) to zebrafish (Danio rerio) using a systematic experimental approach. Results from 96-h semi-static test indicated that the LC50 values of KRM to D. rerio at multiple life stages (embryonic, larval, juvenile and adult stages) ranged from 0...
March 20, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29572434/convergence-and-divergence-of-crh-amacrine-cells-in-mouse-retinal-circuitry
#12
Silvia J H Park, Joseph Pottackal, Jiang-Bin Ke, Na Young Jun, Pouyan Rahmani, In-Jung Kim, Joshua H Singer, Jonathan B Demb
Inhibitory interneurons sculpt the outputs of excitatory circuits to expand the dynamic range of information processing. In mammalian retina, more than 30 types of amacrine cells provide lateral inhibition to vertical, excitatory bipolar cell circuits, but functional roles for only a few amacrine cells are well established. Here, we elucidate the function of corticotropin-releasing hormone (CRH)-expressing amacrine cells labeled in Cre transgenic mice of either sex. CRH cells co-stratify with the ON Alpha ganglion cell, a neuron highly sensitive to positive contrast...
March 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29568676/maternal-separation-affects-expression-of-stress-response-genes-and-increases-vulnerability-to-ethanol-consumption
#13
Taciani de Almeida Magalhães, Diego Correia, Luana Martins de Carvalho, Samara Damasceno, Ana Lúcia Brunialti Godard
Introduction: Maternal separation is an early life stress event associated with behavioral alterations and ethanol consumption. We aimed to expand the current understanding on the molecular mechanisms mediating the impact of postnatal stress on ethanol consumption. Methods: In the first experiment (T1), some of the pups were separated from their mothers for 6 hr daily (Maternal Separation group - MS), whereas the other pups remained in the cage with their respective mothers (Control group - C)...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29565738/maternal-androgen-excess-and-obesity-induce-sexually-dimorphic-anxiety-like-behavior-in-the-offspring
#14
Maria Manti, Romina Fornes, Xiaojuan Qi, Elin Folmerz, Angelica Lindén Hirschberg, Thais de Castro Barbosa, Manuel Maliqueo, Anna Benrick, Elisabet Stener-Victorin
Maternal polycystic ovary syndrome (PCOS), a condition associated with hyperandrogenism, is suggested to increase anxiety-like behavior in the offspring. Because PCOS is closely linked to obesity, we investigated the impact of an adverse hormonal or metabolic maternal environment and offspring obesity on anxiety in the offspring. The obese PCOS phenotype was induced by chronic high-fat-high-sucrose (HFHS) consumption together with prenatal dihydrotestosterone exposure in mouse dams. Anxiety-like behavior was assessed in adult offspring with the elevated-plus maze and open-field tests...
March 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29560959/-the-first-experience-of-tapp-and-tep-allohernioplasty-in-patients-with-inguinal-hernias-at-crh
#15
A A Polyakov
AIM: To improve the outcomes in patients with inguinal hernias by application of advanced minimally invasive procedures. MATERIAL AND METHODS: The article describes an experience of 59 laparoscopic allohernioplasties in 48 patients at the central regional hospital. There were bilateral hernias in 11 cases. Transabdominal preperitoneal (n=49) and extraperitoneal (n=10) placement of polypropylene mesh graft were used. RESULTS: Intraoperative complications such as sigmoid colon lesion occurred in 2 patients with sliding left-sided hernia...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29560385/c-fos-mapping-of-brain-regions-activated-by-multi-modal-and-electric-foot-shock-stress
#16
Xiaoxiao Lin, Christy A Itoga, Sharif Taha, Ming H Li, Ryan Chen, Kirolos Sami, Fulvia Berton, Walter Francesconi, Xiangmin Xu
Real-world stressors are complex and multimodal, involving physical, psychological, and social dimensions. However, the brain networks that mediate stress responses to these stimuli need to be further studied. We used c-Fos mapping in mice to characterize brain circuits activated by exposure to a single episode of multimodal stress (MMS), and compared these to circuits activated by electric foot shocks (EFS). We focused on characterizing c-Fos activity in stress-relevant brain regions including the paraventricular nucleus (PVN) of the hypothalamus and the bed nucleus of the stria terminalis (BNST)...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29543532/crh-crhr1-mediates-prenatal-synthetic-glucocorticoid-programming-of-depression-like-behavior-across-2-generations
#17
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29530929/separate-roles-for-med12-and-wnt-signaling-in-regulation-of-oxytocin-expression
#18
Emma D Spikol, Eric Glasgow
Transcriptional control of oxytocinergic cell development influences social, sexual, and appetite related behaviors, and is implicated in disorders such as autism and Prader-Willi syndrome. Mediator 12 (Med12) is a transcriptional coactivator required for multiple facets of brain development including subsets of serotonergic and dopaminergic neurons. We surveyed hormone gene expression within the hypothalamo-pituitary axis of med12 mutant zebrafish embryos with a focus on oxytocin ( oxt ) expression. Some transcripts, such as oxt , vasopressin ( avp ) and corticotrophin releasing hormone ( crh ) are undetectable in the med12 mutant, while others are upregulated or downregulated to varying degrees...
March 12, 2018: Biology Open
https://www.readbyqxmd.com/read/29514981/structural-basis-for-the-regulatory-interaction-of-the-methylglyoxal-synthase-mgsa-with-the-carbon-flux-regulator-crh-in-bacillus-subtilis
#19
Achim Dickmanns, Christopher P Zschiedrich, Johannes Arens, Iwan Parfentev, Jan Gundlach, Romina Hofele, Piotr Neumann, Henning Urlaub, Boris Görke, Ralf Ficner, Jorg Stulke
Utilization of energy-rich carbon sources such as glucose is fundamental to the evolutionary success of bacteria. Glucose can be catabolized via glycolysis for feeding the intermediary metabolism. The methylglyoxal synthase MgsA produces methylglyoxal from the glycolytic intermediate dihydroxyacetone phosphate. Methylglyoxal is toxic, requiring stringent regulation of MgsA activity. In the Gram-positive bacterium Bacillus subtilis , an interaction with the phosphoprotein Crh controls MgsA activity. In the absence of preferred carbon sources, Crh is present in the nonphosphorylated state and binds to and thereby inhibits MgsA...
March 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29511121/a-role-for-corticotropin-releasing-factor-signaling-in-the-lateral-habenula-and-its-modulation-by-early-life-stress
#20
Michael E Authement, Ludovic D Langlois, Ryan D Shepard, Caroline A Browne, Irwin Lucki, Haifa Kassis, Fereshteh S Nugent
Centrally released corticotropin-releasing factor or hormone (extrahypothalamic CRF or CRH) in the brain is involved in the behavioral and emotional responses to stress. The lateral habenula (LHb) is an epithalamic brain region involved in value-based decision-making and stress evasion. Through its inhibition of dopamine-mediated reward circuitry, the increased activity of the LHb is associated with addiction, depression, schizophrenia, and behavioral disorders. We found that extrahypothalamic CRF neurotransmission increased neuronal excitability in the LHb...
March 6, 2018: Science Signaling
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