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https://www.readbyqxmd.com/read/29932809/dominance-relationships-in-syrian-hamsters-modulate-neuroendocrine-and-behavioral-responses-to-social-stress
#1
Brooke N Dulka, Richa Koul-Tiwari, J Alex Grizzell, Marquinta L Harvey, Subimal Datta, Matthew A Cooper
Stress is a well-known risk factor for psychopathology and rodent models of social defeat have strong face, etiological, construct and predictive validity for these conditions. Syrian hamsters are highly aggressive and territorial, but after an acute social defeat experience they become submissive and no longer defend their home territory, even from a smaller, non-aggressive intruder. This defeat-induced change in social behavior is called conditioned defeat (CD). We have shown that dominant hamsters show increased neural activity in the ventromedial prefrontal cortex (vmPFC) following social defeat stress and exhibit a reduced CD response at social interaction testing compared to subordinates...
June 22, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29921267/an-unusual-case-of-ectopic-corticotrophin-releasing-hormone-syndrome-caused-by-an-adrenal-noncatecholamine-secreting-pheochromocytoma-a-case-report
#2
Bao-Ping Wang, Lei-Lei Yang, Hao Wang, Qing He, Zhong-Shu Ma, Yi Lin, Chang-Xin Jiang, Hao-Ran Sun, Ming Liu
BACKGROUND: Pheochromocytoma, especially for noncatecholamine-secreting pheochromocytoma, is an extremely rare cause of ectopic corticotrophin-releasing hormone (CRH) syndrome. CASE PRESENTATION: A 27-year-old Chinese woman was administered dexamethasone for a skin allergy, but her general condition rapidly deteriorated over a month. She was subsequently hospitalized for typical clinical features of Cushing's syndrome. Endocrinological investigation confirmed severe hypercortisolism along with elevated plasma adrenocorticotropin hormone (ACTH)...
June 19, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29916119/endometrial-crh-and-implantation-from-bench-to-bedside
#3
REVIEW
Antonis Makrigiannakis, Thomas Vrekoussis, Emmanouel Zoumakis, Vassilia Hatzidakis, Eugenia Vlachou, Nicolaos Salakos, Sophia N Kalantaridou
Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer...
June 18, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911619/the-effect-of-tail-docking-in-neonatal-pigs-on-the-central-expression-of-genes-involved-in-modulating-anxiety-like-behaviour
#4
P Oberst, D A Sandercock, P Di Giminiani, S A Edwards, P J Brunton
Background Adverse experiences in early life, such as exposure to stress, can have long term detrimental effects on the future physiology and behaviour of the animal. Typically animals exposed to such experiences are more anxious and more reactive to stress in later life. Tail biting is a major problem in modern pig production, both in terms of animal welfare and productivity. Tail docking in early postnatal life is common practice to reduce risk of this problem, but causes pain and may alter pain sensitivity...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29907890/impact-of-mast-cells-in-depression-disorder-inhibitory-effect-of-il-37-new-frontiers
#5
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Chiara M Conti, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and thoughts is a major risk factor for several metabolic diseases and may influence the physiology of the body leading to depression. Depression, present in mastocytosis, is an important endogenous process that promotes the activation of meningeal cell receptors through a low-grade neurogenic chronic inflammation, and MCs...
June 16, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29904149/stress-peptides-sensitize-fear-circuitry-to-promote-passive-coping
#6
Pinelopi Pliota, Vincent Böhm, Florian Grössl, Johannes Griessner, Ornella Valenti, Klaus Kraitsy, Joanna Kaczanowska, Manuel Pasieka, Thomas Lendl, Jan M Deussing, Wulf Haubensak
Survival relies on optimizing behavioral responses through experience. Animals often react to acute stress by switching to passive behavioral responses when coping with environmental challenge. Despite recent advances in dissecting mammalian circuitry for Pavlovian fear, the neuronal basis underlying this form of non-Pavlovian anxiety-related behavioral plasticity remains poorly understood. Here, we report that aversive experience recruits the posterior paraventricular thalamus (PVT) and corticotropin-releasing hormone (CRH) and sensitizes a Pavlovian fear circuit to promote passive responding...
June 14, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29902479/single-oral-administration-of-flavan-3-ols-induces-stress-responses-monitored-with-stress-hormone-elevations-in-the-plasma-and-paraventricular-nucleus
#7
Yasuyuki Fujii, Kenta Suzuki, Yahiro Hasegawa, Fumio Nanba, Toshiya Toda, Takahiro Adachi, Shu Taira, Naomi Osakabe
We previously confirmed that postprandial alterations in the circulation and metabolism after a single oral dose of flavan 3-ols (mixture of catechin and catechin oligomers) were involved in an increase in sympathetic nervous activity. However, it is well known that, in response to various stresses, activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs together with sympathetic nerve activity, which is associated with activation of the sympathetic-adrenal-medullary (SAM) axis. In this study, we examined whether the HPA axis was activated after a single dose of flavan 3-ols...
June 11, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29901836/chronic-stress-dampens-excitatory-synaptic-gain-in-the-paraventricular-nucleus-of-the-hypothalamus
#8
Eric Salter, Julia Sunstrum, Sara Matovic, Wataru Inoue
KEY POINTS: Glutamatergic synaptic inputs to corticotropin releasing hormone (CRH) secreting neurons in the paraventricular nucleus of the hypothalamus (PVN) are required for stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. These synapses also undergo stress-induced plasticity thereby influencing HPA axis stress adaptation. By using patch clamp electrophysiology, we show that, in adult non-stressed mice, action potentials at these glutamatergic afferents elicit multiquantal transmission to the postsynaptic PVN-CRH neurons (i...
June 14, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29900811/anxiety-like-behavior-and-structural-changes-of-the-bed-nucleus-of-the-stria-terminalis-bnst-in-gestational-protein-restricted-male-offspring
#9
D B Torres, A Lopes, A J Rodrigues, J J Cerqueira, N Sousa, J A R Gontijo, P A Boer
Animal evidence has suggested that maternal emotional and nutritional stress during pregnancy is associated with behavioral outcomes in offspring. The nature of the stresses applied may differ, but it is often assumed that the mother's hippocampus-hypothalamic-pituitary-adrenal (HHPA) axis response releases higher levels of glucocorticoid hormones. The bed nucleus of the stria terminalis (BNST) is in a pivotal position to regulate the HHPA axis and the stress response, and it has been implicated in anxiety behavior...
June 14, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29884193/differential-responses-of-stressful-elements-to-predatory-exposure-in-behavior-lateralized-mice
#10
Jiacai Yang, Lin Zhang, Jian-Ping Dai, Jun Zeng, Xiao-Xuan Chen, Ze-Feng Xie, Kang-Sheng Li, Yun Su
BACKGROUND: Predatory stress as a psychological stressor can elicit the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the dialogue of the neuroimmunoendocrine network. The brain has been proven to regulate the activity of the HPA axis by way of lateralization. In the present study, we probed the pivotal elements of the HPA circuitry including CRH, GR and a multifunctional cytokine in behavior-lateralized mice to determine their changes when the animals were subjected to predator exposure...
June 8, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29883955/microcystin-lr-affects-the-hypothalamic-pituitary-inter-renal-hpi-axis-in-early-life-stages-embryos-and-larvae-of-zebrafish
#11
Liang Chen, Yeke Wang, John P Giesy, Feng Chen, Ting Shi, Jun Chen, Ping Xie
Frequencies and durations of blooms of cyanobacteria are increasing. Some cyanobacteria can produce cyanotoxins including microcystins (MCs). MCs are the most common toxic products of hazardous algal blooms (HABs), with the greatest potential for exposure and to cause toxicity. Recently, MCs have been shown to disrupt endocrine functions. In this study, for the first time, effects of MC-LR on the hypothalamic-pituitary-inter-renal (HPI) axis during early embryonic development (embryos/larvae) of zebrafish (Danio rerio), were investigated...
May 22, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29878268/the-protein-status-of-rats-affects-the-rewarding-value-of-meals-due-to-their-protein-content
#12
Catherine Chaumontet, Isidra Recio, Gilles Fromentin, Simon Benoit, Julien Piedcoq, Nicolas Darcel, Daniel Tomé
Background: Protein status is controlled by the brain, which modulates feeding behavior to prevent protein deficiency. Objective: This study tested in rats whether protein status modulates feeding behavior through brain reward pathways. Methods: Experiments were conducted in male Wistar rats (mean ± SD weight; 230 ± 16 g). In experiment 1, rats adapted for 2 wk to a low-protein (LP; 6% of energy) or a normal-protein (NP; 14% of energy) diet were offered a choice between 3 cups containing high-protein (HP; 50% of energy), NP, or LP feed; their intake was measured for 24 h...
June 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29867541/prediction-of-molecular-mechanisms-for-lianxia-ningxin-formula-a-network-pharmacology-study
#13
Yang Yang, Kuo Yang, Teng Hao, Guodong Zhu, Ruby Ling, Xuezhong Zhou, Ping Li
Objectives: Network pharmacological methods were used to investigate the underlying molecular mechanisms of LianXia NingXin (LXNX) formula, a Chinese prescription, to treat coronary heart disease (CHD) and disease phenotypes (CHD related diseases and symptoms). Methods: The different seed gene lists associated with the herbs of LXNX formula, the CHD co-morbid diseases and symptoms which were relieved by the LXNX formula (co-morbid diseases and symptoms) were curated manually from biomedical databases and published biomedical literatures...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29786085/chronic-crh-depletion-from-gabaergic-long-range-projection-neurons-in-the-extended-amygdala-reduces-dopamine-release-and-increases-anxiety
#14
Nina Dedic, Claudia Kühne, Mira Jakovcevski, Jakob Hartmann, Andreas J Genewsky, Karina S Gomes, Elmira Anderzhanova, Max L Pöhlmann, Simon Chang, Adam Kolarz, Annette M Vogl, Julien Dine, Michael W Metzger, Bianca Schmid, Rafael C Almada, Kerry J Ressler, Carsten T Wotjak, Valery Grinevich, Alon Chen, Mathias V Schmidt, Wolfgang Wurst, Damian Refojo, Jan M Deussing
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release...
June 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29777689/forever-young-endocrinology-of-paedomorphosis-in-the-mexican-axolotl-ambystoma-mexicanum
#15
REVIEW
Bert De Groef, Sylvia V H Grommen, Veerle M Darras
The Mexican axolotl (Ambystoma mexicanum) is a salamander species that does not undergo metamorphosis, resulting in the retention of juvenile characteristics in the mature breeding stage (paedomorphosis). Here we review the endocrinological studies investigating the proximate cause of axolotl paedomorphosis with a focus on the hypothalamo-pituitary-thyroid (HPT) axis. It is well established that axolotl paedomorphosis is a consequence of low activity of the HPT axis. The pituitary hormone thyrotropin (TSH) is capable of inducing metamorphosis in the axolotl, which indicates that all processes and interactions in the HPT axis below the pituitary level are functional, but that TSH release is impaired...
May 16, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29772675/silencing-stem-cell-factor-gene-in-fibroblasts-to-regulate-paracrine-factor-productions-and-enhance-c-kit-expression-in-melanocytes-on-melanogenesis
#16
Pin-Hui Li, Li-Heng Liu, Cheng-Chung Chang, Rong Gao, Chung-Hang Leung, Dik-Lung Ma, Hui-Min David Wang
Melanogenesis is a complex physiological mechanism involving various paracrine factors. Skin cells such as keratinocytes, fibroblasts, and melanocytes communicate with one another through secreted regulators, thereby regulating the melanocytes' bio-functions. The stem cell factor (SCF) is a paracrine factor produced by fibroblasts, and its receptor, c-kit, is expressed on melanocytes. Binding of SCF to c-kit activates autophosphorylation and tyrosine kinase to switch on its signal transmission. SCF inhibition does not suppress fibroblast proliferation in MTT assay, and SCF silencing induced mRNA expressions of paracrine factor genes, HGF , NRG-1 , and CRH in qPCR results...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29770110/a-pcr-based-method-for-rna-probes-and-applications-in-neuroscience
#17
Ruifang Hua, Shanshan Yu, Mugen Liu, Haohong Li
In situ hybridization (ISH) is a powerful technique that is used to detect the localization of specific nucleic acid sequences for understanding the organization, regulation, and function of genes. However, in most cases, RNA probes are obtained by in vitro transcription from plasmids containing specific promoter elements and mRNA-specific cDNA. Probes originating from plasmid vectors are time-consuming and not suitable for the rapid gene mapping. Here, we introduce a simplified method to prepare digoxigenin (DIG)-labeled non-radioactive RNA probes based on polymerase chain reaction (PCR) amplification and applications in free-floating mouse brain sections...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29755405/dual-paraneoplastic-endocrine-syndromes-heralding-onset-of-extrapulmonary-small-cell-carcinoma-a-case-report-and-narrative-review
#18
Jill B Feffer, Natalia M Branis, Jeanine B Albu
Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance. Methods: Clinical, laboratory, imaging, and pathology data are presented. Results: A 56-year-old man with locally advanced prostate adenocarcinoma on androgen deprivation therapy presented with a clogged nephrostomy tube...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29751401/exposure-to-pfdoa-causes-disruption-of-the-hypothalamus-pituitary-thyroid-axis-in-zebrafish-larvae
#19
Shengnan Zhang, Xiaochun Guo, Shaoyong Lu, Nan Sang, Guangyu Li, Ping Xie, Chunsheng Liu, Liguo Zhang, Yi Xing
Perfluorododecanoic acid (PFDoA), a kind of perfluorinated carboxylic acid (PFCA) with 12 carbon atoms, has an extensive industrial utilization and is widespread in both wildlife and the water environment, and was reported to have the potential to cause a disruption in the thyroid hormone system homeostasis. In this study, zebrafish embryos/larvae were exposed to different concentrations of PFDoA (0, 0.24, 1.2, 6 mg/L) for 96 h post-fertilization (hpf). PFDoA exposure caused obvious growth restriction connected with the reduced thyroid hormones (THs) contents in zebrafish larvae, strengthening the interference effect on the growth of fish larvae...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29751050/effects-of-hypergravity-on-the-gene-expression-of-the-hypothalamic-feeding-related-neuropeptides-in-mice-via-vestibular-inputs
#20
Satomi Sonoda, Mitsuhiro Yoshimura, Chikara Abe, Hironobu Morita, Hiromichi Ueno, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Hirofumi Hashimoto, Yoshiya Tanaka, Yoichi Ueta
The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham but not in VL mice after 3 days of exposure to a 2 g environment compared with a 1 g environment. Significant decreases in pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript and significant increases in neuropeptide Y, agouti-related protein in the arcuate nucleus and orexin in the lateral hypothalamic area were observed in both Sham and VL mice...
May 8, 2018: Peptides
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