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Abernethy

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https://www.readbyqxmd.com/read/28426943/how-strong-is-the-evidence-for-using-blood-biomarkers-alone-to-screen-for-alcohol-consumption-during-pregnancy-a-systematic-review
#1
Helen Howlett, Sarah Abernethy, Nigel W Brown, Judith Rankin, William K Gray
Accurate and early identification of women at risk from alcohol consumption during pregnancy allows education and support programmes to be targeted at those most in need. We aimed to conduct a systematic review to compare the efficacy of blood analysis and maternal self-report in detecting at risk women during pregnancy. This review investigated diagnostic accuracy. We searched four databases (Medline, Embase, Psychinfo and CINAHL) for relevant articles and conducted hand searches of recent issues of key journals in the field...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28425418/recurrent-hyperammonemia-after-abernethy-malformation-type-2-closure-a-case-report
#2
Hui Li, Zhi Ma, Ying Xie, Feng Tian
The Abernethy malformation is a rare congenital malformation defined by the presence of an extrahepatic portosystemic shunt. Although most patients are asymptomatic, clinical encephalopathy is present in 15% of cases. We present a patient with type 2 Abernethy malformation, hyperammonemia, and encephalopathy. Shunt closure was performed successfully using interventional angiography; however, hyperammonemia recurred 3 months later. The diagnosis of Abernethy malformation can be made easily, but the ideal patient management strategy has not yet been established...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28410536/the-influence-of-ball-swing-on-the-timing-and-coordination-of-a-natural-interceptive-task
#3
Vishnu Sarpeshkar, David L Mann, Wayne Spratford, Bruce Abernethy
Successful interception relies on the use of perceptual information to accurately guide an efficient movement strategy that allows performers to be placed at the right place at the right time. Although previous studies have highlighted the differences in the timing and coordination of movement that underpin interceptive expertise, very little is known about how these movement patterns are adapted when intercepting targets that follow a curvilinear flight-path. The aim of this study was to examine how curvilinear ball-trajectories influence movement patterns when intercepting a fast-moving target...
April 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28408335/optimizing-delivery-of-a-behavioral-pain-intervention-in-cancer-patients-using-a-sequential-multiple-assignment-randomized-trial-smart
#4
Sarah A Kelleher, Caroline S Dorfman, Jen C Plumb Vilardaga, Catherine Majestic, Joseph Winger, Vicky Gandhi, Christine Nunez, Alyssa Van Denburg, Rebecca A Shelby, Shelby D Reed, Susan Murphy, Marie Davidian, Eric B Laber, Gretchen G Kimmick, Kelly W Westbrook, Amy P Abernethy, Tamara J Somers
BACKGROUND/AIMS: Pain is common in cancer patients and results in lower quality of life, depression, poor physical functioning, financial difficulty, and decreased survival time. Behavioral pain interventions are effective and nonpharmacologic. Traditional randomized controlled trials (RCT) test interventions of fixed time and dose, which poorly represent successive treatment decisions in clinical practice. We utilize a novel approach to conduct a RCT, the sequential multiple assignment randomized trial (SMART) design, to provide comparative evidence of: 1) response to differing initial doses of a pain coping skills training (PCST) intervention and 2) intervention dose sequences adjusted based on patient response...
April 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28399109/tyrosine-kinase-targeting-drugs-associated-heart-failure
#5
N Gronich, I Lavi, O Barnett-Griness, W Saliba, D R Abernethy, G Rennert
BACKGROUND: The impact of cancer therapies on cardiac disease in the general adult cancer survivor population is largely unknown. Our objective was to evaluate which tyrosine kinase-targeting drugs are associated with greater risk for new-onset heart failure (HF). METHODS: A nested case-control analysis was conducted within a cohort of 27 992 patients of Clalit Health Services, newly treated with a tyrosine kinase-targeting, and/or chemotherapeutic drug, for a malignant disease, between 1 January 2005 and 31 December 2012...
April 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28392087/evaluation-of-the-methodological-quality-of-studies-of-the-performance-of-diagnostic-tests-for-bovine-tuberculosis-using-quadas
#6
Sara H Downs, Simon J More, Anthony V Goodchild, Adam O Whelan, Darrell A Abernethy, Jennifer M Broughan, Angus Cameron, Alasdair J Cook, R Ricardo de la Rua-Domenech, Matthias Greiner, Jane Gunn, Javier Nuñez-Garcia, Shelley Rhodes, Simon Rolfe, Michael Sharp, Paul Upton, Eamon Watson, Michael Welsh, John A Woolliams, Richard S Clifton-Hadley, Jessica E Parry
There has been little assessment of the methodological quality of studies measuring the performance (sensitivity and/or specificity) of diagnostic tests for animal diseases. In a systematic review, 190 studies of tests for bovine tuberculosis (bTB) in cattle (published 1934-2009) were assessed by at least one of 18 reviewers using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies) checklist adapted for animal disease tests. VETQUADAS (VQ) included items measuring clarity in reporting (n=3), internal validity (n=9) and external validity (n=2)...
March 22, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28384148/provision-of-stroke-thrombolysis-services-in-new-zealand-changes-between-2011-and-2016
#7
Qiliang Liu, Annemarei Anna Ranta, Ginny Abernethy, P Alan Barber
AIMS: To obtain an overall picture of the organisation of stroke thrombolysis provision in New Zealand hospitals and compare changes between 2011 and 2016. METHODS: Surveys were distributed to all New Zealand district health boards (DHBs) in 2011 and 2016, and included questions about the infrastructure, staffing, training, guidelines and audit provided for stroke thrombolysis. RESULTS: Responses were received from all DHBs, with 86% offering stroke thrombolysis in 2011 and 100% in 2016...
April 7, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28384147/trends-in-new-zealand-stroke-thrombolysis-treatment-rates
#8
Qiliang Liu, Annemarei Anna Ranta, Ginny Abernethy, P Alan Barber
AIMS: To describe trends in treatment delays and short-term outcome over the first 18 months of the New Zealand stroke thrombolysis register. METHODS: The National Stroke Network introduced a central register of all ischaemic stroke patients treated with intravenous alteplase on January 1, 2015. The aim was to increase thrombolysis treatment rates and drive improvements in safety. RESULTS: From January 1, 2015 to June 30, 2016, alteplase was given to 623 patients [344 men, mean (range) age 70 (22-98) years] out of a total of 8,857 ischaemic and unspecified stroke patients, giving a thrombolysis rate of 7...
April 7, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28378109/prevalence-of-cognitive-impairment-in-older-women-with-pelvic-floor-disorders
#9
Cynelle Murray Kunkle, Melinda G Abernethy, Lily R Van Tongeren, Tola B Fashokun, Edward J Wright, Chi Chiung Grace Chen
INTRODUCTION AND HYPOTHESIS: This study aimed to determine the prevalence of mild cognitive impairment (MCI) and early dementia among women >55 years seeking care for pelvic floor disorders (PFDs) and to describe the impact of cognitive impairment on condition-specific quality of life (QoL). We hypothesized that the prevalence of MCI would be at least 15% among this population. METHODS: This was a cross-sectional study of English-speaking women >55 years presenting for evaluation of PFDs...
April 4, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28368708/design-and-rationale-of-the-metastatic-renal-cell-carcinoma-marcc-registry-a-prospective-academic-and-community-based-study-of-patients-with-metastatic-renal-cell-cancer
#10
Nrupen A Bhavsar, Michael R Harrison, Bradford R Hirsch, Patricia Creel, Steve P Wolf, Greg P Samsa, Amy P Abernethy, Ronit Simantov, Azah Borham, Daniel J George
The Metastatic Renal Cell Cancer Registry, a large, nationally representative, prospective registry of patients with metastatic renal cell carcinoma (mRCC), aims to understand real-world treatment patterns and outcomes of patients with mRCC in routine clinical practice across the United States. This observational study is designed to enroll 500 patients with previously untreated mRCC from approximately 60 academic and community treatment sites; as of December 7, 2016, 500 patients have enrolled at 54 sites...
April 3, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28347519/meta-analyses-of-the-sensitivity-and-specificity-of-ante-mortem-and-post-mortem-diagnostic-tests-for-bovine-tuberculosis-in-the-uk-and-ireland
#11
Javier Nuñez-Garcia, Sara H Downs, Jessica E Parry, Darrell A Abernethy, Jennifer M Broughan, Angus R Cameron, Alasdair J Cook, Ricardo de la Rua-Domenech, Anthony V Goodchild, Jane Gunn, Simon J More, Shelley Rhodes, Simon Rolfe, Michael Sharp, Paul A Upton, H Martin Vordermeier, Eamon Watson, Michael Welsh, Adam O Whelan, John A Woolliams, Richard S Clifton-Hadley, Matthias Greiner
Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accurate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was, through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 different ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic review of the scientific literature (published 1934-2009) diagnostic Se and Sp were estimated using Bayesian logistic regression models adjusting for confounding factors...
March 6, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28338118/unusual-discovery-after-an-examination-for-abdominal-pain-abernethy-1b-malformation-and-liver-adenomatosis-a-case-report
#12
Romeo Ioan Chira, Adriana Calauz, Simona Manole, Simona Valean, Petru Adrian Mircea
Congenital extrahepatic portosystemic shunt (Abernethy malformation) is a rare condition characterized by developmental abnormalities of the portal venous system resulting in the diversion of the portal blood from the liver to the systemic venous system through a complete or partial shunt of the portomesenteric blood. We report the case of an 18 year-old female examined for abdominal pain, presenting cholestasis syndrome and an elevated serum aspartate aminotransferase level. Liver ultrasound examination revealed the absence of the portal vein with a complete extrahepatic shunt of the portal blood, multiple focal liver lesions, and multiple associated vascular anomalies...
March 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28302006/transplantation-for-large-liver-tumors-in-the-setting-of-abernethy-malformation
#13
İlgin Özden, Ayşen Yavru, Mine Güllüoğlu, Aydin Alper, Orhan Bilge, Serdar Cantez, Özlem Durmaz
In this study, we report our experiences on the role of transplantation in 2 patients with large liver tumors in the setting of Abernethy malformation. Patient 1 was a 17-year-old boy who was referred for hepatic masses and recurrent hepatic encephalopathy episodes. Computed tomography and magnetic resonance imaging showed 2 large tumors (4 and 8 cm) in the liver. The portal vein drained directly into the vena cava. Core biopsy of the larger mass revealed fibrosis and regenerative hyperplasia. There were hyperintense signals in the T1-weighted images in the globus pallidus...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28282304/the-digital-drag-and-drop-pillbox-design-and-feasibility-of-a-skill-based-education-model-to-improve-medication-management
#14
Bradi B Granger, Susan C Locke, Margaret Bowers, Tenita Sawyer, Howard Shang, Amy P Abernethy, Richard A Bloomfield, Catherine L Gilliss
OBJECTIVE: We present the design and feasibility testing for the "Digital Drag and Drop Pillbox" (D-3 Pillbox), a skill-based educational approach that engages patients and providers, measures performance, and generates reports of medication management skills. METHODS: A single-cohort convenience sample of patients hospitalized with heart failure was taught pill management skills using a tablet-based D-3 Pillbox. Medication reconciliation was conducted, and aptitude, performance (% completed), accuracy (% correct), and feasibility were measured...
March 9, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28277355/activity-restriction-recommendations-and-outcomes-after-reconstructive-pelvic-surgery-a-randomized-controlled-trial
#15
Margaret G Mueller, Christina Lewicky-Gaupp, Sarah A Collins, Melinda G Abernethy, Alex Alverdy, Kimberly Kenton
OBJECTIVE: To assess the relationship between prescribed postoperative activity recommendations (liberal compared with restricted) after reconstructive prolapse surgery and patient satisfaction and pelvic floor symptoms. METHODS: In our multicenter, randomized, double-blind clinical trial, women undergoing reconstructive prolapse surgery were randomized to liberal compared with restricted postoperative activity recommendations. Liberal recommendations instructed women to resume postoperative activity at the woman's own pace with no restrictions on lifting or high-impact activities...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28190700/epidemiology-of-escherichia-coli-bacteraemia-in-england-results-of-an-enhanced-sentinel-surveillance-programme
#16
J Abernethy, R Guy, E A Sheridan, S Hopkins, M Kiernan, M H Wilcox, A P Johnson, R Hope
BACKGROUND: Escherichia coli causes more than one-third of the bacteraemia cases in England each year, and the incidence of these infections is increasing. AIM: To determine the underlying risk factors associated with E. coli bacteraemia. METHODS: A three-month enhanced sentinel surveillance study involving 35 National Health Service hospitals was undertaken in the winter of 2012/13 to collect risk factor information and further details on the underlying source of infection to augment data already collected by the English national surveillance programme...
April 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28178051/urinary-microbiome-and-cytokine-levels-in-women-with-interstitial-cystitis
#17
Melinda G Abernethy, Amy Rosenfeld, James R White, Margaret G Mueller, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVE: To investigate differences in the urinary microbiome and cytokine levels between women with and without interstitial cystitis and to correlate differences with scores on standardized symptom severity scales and depression and anxiety screening tools. METHODS: Our cross-sectional study compared women presenting to a pelvic floor clinic and diagnosed with interstitial cystitis over a 6-month period with age-matched women in a control group from the same institution...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28156604/efficacy-of-anamorelin-in-cachectic-patients-with-non-small-cell-lung-cancer-nsclc-and-low-bmi-20-kg-m-2-post-hoc-analysis-of-two-phase-iii-studies
#18
Jennifer S Temel, Amy Pickar Abernethy, Ruben Giorgino, John Friend, Kenneth Fearon
203 Background: Patients with advanced cancer frequently experience anorexia/cachexia, which can be characterized by weight loss or low BMI, and is associated with reduced function and quality of life. The randomized, phase III, double-blind ROMANA 1 [NCT01387269; N = 484] and ROMANA 2 [NCT01387282; N = 495]) trials in cachectic NSCLC patients demonstrated that the ghrelin receptor agonist anamorelin improved LBM, body weight, fat mass (FM), and symptom burden compared with placebo, and was well tolerated. The aim of this analysis was to assess the response to anamorelin specifically in patients with BMI below 20 kg/m(2)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156470/patient-reported-distress-in-adults-with-myelodysplastic-syndromes-mds
#19
Carlos deCastro, Mary Ruth Pupa, Greg P Samsa, Amy Pickar Abernethy, Thomas William LeBlanc
80 Background: MDS are hematopoietic malignancies that are incurable in most patients. The National Comprehensive Cancer Network (NCCN) defines distress as an unpleasant emotional experience associated with the psychosocial complications of cancer that may interfere with quality of life. Distress is not well described in MDS and may be useful to screen for palliative care needs. METHODS: We conducted a retrospective review of distress in ambulatory adult MDS patients visiting our clinics from July 2013 to September 2015...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156435/sleep-quality-among-inpatients-with-acute-myeloid-leukemia
#20
Kelli Aibel, Ryan Meyerhoff, David Harpole, Amy Pickar Abernethy, Chi-Fu Jeffrey Yang
82 Background: Anecdotally, sleep is thought to be a significant problem for inpatients receiving treatment for acute myeloid leukemia (AML), butsleep disturbances in this setting are not well-characterized. We aimed to assess the feasibility of measuring sleep in AML patients using a wearable actigraphy device. METHODS: Using the Actigraph GT3X "watch,"we assessed the total sleep time, sleep onset latency, wake after sleep onset, number of awakenings after sleep onset, and sleep efficiency for inpatients with AML receiving induction chemotherapy during their hospitalization...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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