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https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#1
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27891575/multiple-sclerosis-impact-on-employment-and-income-in-new-zealand
#2
J F Pearson, S Alla, G Clarke, D F Mason, T Anderson, A Richardson, D H Miller, C E Sabel, D A Abernethy, E W Willoughby, B V Taylor
BACKGROUND AND OBJECTIVES: We investigated the demographic, social and clinical characteristics associated with employment status and income for people with multiple sclerosis (MS) in New Zealand (NZ). METHODS: The NZ National MS Prevalence study included all persons resident in NZ on census day 2006 diagnosed with MS (96.7% coverage). Factors associated with employment and income status among the working age population (25-64 years) were identified by linear regression...
November 28, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27891252/a-small-randomized-controlled-pilot-trial-comparing-mobile-and-traditional-pain-coping-skills-training-protocols-for-cancer-patients-with-pain
#3
Tamara J Somers, Sarah A Kelleher, Kelly W Westbrook, Gretchen G Kimmick, Rebecca A Shelby, Amy P Abernethy, Francis J Keefe
Psychosocial pain management interventions are efficacious for cancer pain but are underutilized. Recent advances in mobile health (mHealth) technologies provide new opportunities to decrease barriers to access psychosocial pain management interventions. The objective of this study was to gain information about the accessibility and efficacy of mobile pain coping skills training (mPCST) intervention delivered to cancer patients with pain compared to traditional in-person pain coping skills training intervention...
2016: Pain Research and Treatment
https://www.readbyqxmd.com/read/27886372/oxygen-for-breathlessness-in-patients-with-chronic-obstructive-pulmonary-disease-who-do-not-qualify-for-home-oxygen-therapy
#4
REVIEW
Magnus Ekström, Zainab Ahmadi, Anna Bornefalk-Hermansson, Amy Abernethy, David Currow
BACKGROUND: Breathlessness is a cardinal symptom of chronic obstructive pulmonary disease (COPD). Long-term oxygen therapy (LTOT) is given to improve survival time in people with COPD and severe chronic hypoxaemia at rest. The efficacy of oxygen therapy for breathlessness and health-related quality of life (HRQOL) in people with COPD and mild or no hypoxaemia who do not meet the criteria for LTOT has not been established. OBJECTIVES: To determine the efficacy of oxygen versus air in mildly hypoxaemic or non-hypoxaemic patients with COPD in terms of (1) breathlessness; (2) HRQOL; (3) patient preference whether to continue therapy; and (4) oxygen-related adverse events...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27857464/the-abernethy-malformation-myriad-imaging-manifestations-of-a-single-entity
#5
Samarjit S Ghuman, Saumya Gupta, T B S Buxi, Kishan S Rawat, Anurag Yadav, Naimish Mehta, Seema Sud
Abernethy malformation, also known as congenital extrahepatic portosystemic shunts (CEPS) is a rare clinical entity and manifests with different clinical symptoms. CEPS are abnormalities of vascular development where there is shunting of portal blood into the systemic venous system. Multidetector computed tomography (MDCT) is a fast and effective modality for evaluation of CEPS. CT displays all the information desired by the surgeon as well as the clinician including the anatomy of the splenic and superior mesenteric veins, size and site of the shunt, presence or absence of the portal vein radicles, and helps to plan the therapy and even the follow-up of these patients...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27853564/bushmeat-hunting-and-extinction-risk-to-the-world-s-mammals
#6
William J Ripple, Katharine Abernethy, Matthew G Betts, Guillaume Chapron, Rodolfo Dirzo, Mauro Galetti, Taal Levi, Peter A Lindsey, David W Macdonald, Brian Machovina, Thomas M Newsome, Carlos A Peres, Arian D Wallach, Christopher Wolf, Hillary Young
Terrestrial mammals are experiencing a massive collapse in their population sizes and geographical ranges around the world, but many of the drivers, patterns and consequences of this decline remain poorly understood. Here we provide an analysis showing that bushmeat hunting for mostly food and medicinal products is driving a global crisis whereby 301 terrestrial mammal species are threatened with extinction. Nearly all of these threatened species occur in developing countries where major coexisting threats include deforestation, agricultural expansion, human encroachment and competition with livestock...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27818717/using-patient-reported-outcomes-in-oncology-clinical-practice
#7
Sarah A Kelleher, Tamara J Somers, Tracie Locklear, Alexandra D Crosswell, Amy P Abernethy
BACKGROUND AND AIMS: Patient reported outcomes (PROs) are increasingly being implemented into the care of patients with cancer. The use of a standard set of PROs (e.g., pain) in cancer is becoming established and there is interest in what additional PROs might provide valuable information. The goal of this observational study was to examine how the PROs of self-efficacy for pain and other symptoms assessed at the point of service were associated with pain, symptom severity and distress, and physical and psychosocial functioning in a sample of breast and gastrointestinal patients...
October 2016: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/27765240/degradation-studies-of-cholecalciferol-vitamin-d3-using-hplc-dad-uhplc-ms-ms-and-chemical-derivatization
#8
Fatemeh Mahmoodani, Conrad O Perera, Bruno Fedrizzi, Grant Abernethy, Hong Chen
In any food fortification program, the stability of added micronutrients is an important factor. Cholecalciferol or vitamin D3 is known to isomerise under various conditions, thereby making its analysis challenging. In the current study, the effects of different parameters, such as temperature, iodine, acidic conditions, and oxidation, on the isomerisation of vitamin D3 were studied using HPLC-DAD and UHPLC-MS/MS. Vitamin D3 thermally and reversibly transforms to pre-vitamin D3 type isomers. In the presence of iodine, cis/trans isomerisation of both cholecalciferol and pre-vitamin D3 takes place to form trans-vitamin D3 and tachysterol, respectively...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27727433/improving-the-tools-of-clinical-pharmacology-goals-for-2017-and-beyond
#9
Issam Zineh, Darrell Abernethy, Cornelis E C A Hop, Akintunde Bello, Mark B McClellan, Gregory W Daniel, Morgan H Romine
No abstract text is available yet for this article.
October 11, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27716147/two-colliding-epidemics-obesity-is-independently-associated-with-chronic-pain-interfering-with-activities-of-daily-living-in-adults-18%C3%A2-years-and-over-a-cross-sectional-population-based-study
#10
Sharon A Allen, Eleonora Dal Grande, Amy P Abernethy, David C Currow
BACKGROUND: Chronic pain interfering with activities of daily living is highly prevalent in the community. More than 600 million people worldwide are obese. The aim of this paper is to assess if such chronic pain is associated independently with obesity across the adult population, having controlled for other key factors. METHODS: The South Australian Health Omnibus is an annual, population-based, cross-sectional study. Data on 2616 participants were analysed for episodes of daily pain for three of the preceding six months...
September 30, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27697977/emerging-issues-and-opportunities-in-health-information-technology
#11
Elizabeth A Nardi, Lisa Korin Lentz, Katherine Winckworth-Prejsnar, Amy P Abernethy, Robert W Carlson
When used effectively, health information technology (HIT) can transform clinical care and contribute to new research discoveries. Despite advances in HIT and increased electronic health record adoption, many challenges to optimal use, interoperability, and data sharing exist. Data standardization across systems is limited, and scanned medical note documents result in unstructured data that make reporting on quality measures for reimbursement burdensome. Different policies and initiatives, including the Health Information Technology for Economic and Clinical Health Act, the Medicare Access and CHIP Reauthorization Act, and the National Cancer Moonshot initiative, among others, all recognize the impact that HIT can have on cancer care...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27694998/glatiramer-acetate-treatment-normalized-the-monocyte-activation-profile-in-ms-patients-to-that-of-healthy-controls
#12
Delgertsetseg Chuluundorj, Scott A Harding, David Abernethy, Anne Camille La Flamme
Multiple sclerosis (MS) is an immune-mediated disease of the CNS, and monocytes contribute to MS-associated neuroinflammation. While classically-activated monocytes promote inflammation, type II-activated monocytes improve the course of MS. This study investigated type II activation of monocytes and their two main subsets, namely CD14(+) (CD14(++)CD16(-)subset) and CD16(+) monocytes (CD14(+)CD16(+)subset), by glatiramer acetate (GA) or intravenous immunoglobulin (IVIG)-associated immune complexes (IC), both of which are known MS treatments...
October 3, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27679032/laparoscopic-and-robotic-skills-are-transferable-in-a-simulation-setting
#13
L Thomaier, M Abernethy, C Paka, Ccg Chen
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27663186/anticholinergic-drug-burden-in-noncancer-versus-cancer-patients-near-the-end-of-life
#14
Michael J Hochman, Arif H Kamal, Steven P Wolf, Greg P Samsa, David C Currow, Amy P Abernethy, Thomas W LeBlanc
CONTEXT: Anticholinergic drugs can cause several side effects, impairing cognition and quality of life (QOL). Cancer patients are often exposed to increasing cumulative anticholinergic load (ACL) as they approach death, but this burden has not been examined in patients with nonmalignant diseases. OBJECTIVES: To determine ACL and its impact in noncancer versus cancer palliative care patients. METHODS: We performed a secondary analysis of 244 subjects enrolled in a randomized controlled trial...
September 20, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27647847/relationship-of-albuminuria-and-renal-artery-stent-outcomes-results-from-the-coral-randomized-clinical-trial-cardiovascular-outcomes-with-renal-artery-lesions
#15
Timothy P Murphy, Christopher J Cooper, Karol M Pencina, Ralph D'Agostino, Joseph Massaro, Donald E Cutlip, Kenneth Jamerson, Alan H Matsumoto, William Henrich, Joseph I Shapiro, Katherine R Tuttle, David J Cohen, Michael Steffes, Qi Gao, D Christopher Metzger, William B Abernethy, Stephen C Textor, John Briguglio, Alan T Hirsch, Sheldon Tobe, Lance D Dworkin
: Randomized clinical trials have not shown an additional clinical benefit of renal artery stent placement over optimal medical therapy alone. However, studies of renal artery stent placement have not examined the relationship of albuminuria and treatment group outcomes. The CORAL study (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) is a prospective clinical trial of 947 participants with atherosclerotic renal artery stenosis randomized to optimal medical therapy with or without renal artery stent which showed no treatment differences (3(5...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27639191/gps-for-qsp-a-summary-of-the-acop6-symposium-on-quantitative-systems-pharmacology-and-a-stage-for-near-term-efforts-in-the-field
#16
EDITORIAL
C J Musante, D R Abernethy, S R Allerheiligen, D A Lauffenburger, M G Zager
Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from molecular biology to engineering to pharmacometrics. As a result, there exist critical segments of the discipline that differ dramatically in approach and a need to bring these groups together toward a common goal.
September 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27603500/prevalence-and-outcomes-of-breathlessness-in-older-adults-a-national-population-study
#17
Alexander K Smith, David C Currow, Amy P Abernethy, Miriam J Johnson, Yinghui Miao, W John Boscardin, Christine S Ritchie
OBJECTIVES: To determine the prevalence and outcomes of breathlessness in older Americans. SETTING: Community-dwelling older adults. PARTICIPANTS: Individuals aged 70 and older in the nationally representative Health and Retirement Study (2008, follow-up through 2012) (N = 3,671; mean age 78). MEASUREMENTS: Breathlessness was assessed by asking the question, "How often do you become short of breath while awake?" Responses of often or sometimes were considered to represent a level of breathlessness sufficient to warrant clinical attention...
September 7, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27542450/investigation-of-concentration-of-thiocyanate-ion-in-raw-cow-s-milk-from-china-new-zealand-and-the-netherlands
#18
Ling Yong, Yibaina Wang, Dajin Yang, Zhaoping Liu, Grant Abernethy, Jianwen Li
Thiocyanate ion is a natural component of cow's milk (hereinafter as milk) which may be artificially augmented to activate the lactoperoxidase milk preservation system. This study presents a survey of thiocyanate levels in raw milk and proposes a naturally occurring baseline concentration of thiocyanate in milk, which is the basis for market supervision. 1669 raw milk samples from China, 270 samples from New Zealand and 120 from the Netherlands were collected in the survey. 65% of the samples contained thiocyanate above the detection limit...
January 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27531376/defining-high-quality-palliative-care-in-oncology-practice-an-american-society-of-clinical-oncology-american-academy-of-hospice-and-palliative-medicine-guidance-statement
#19
Kathleen E Bickel, Kristen McNiff, Mary K Buss, Arif Kamal, Dale Lupu, Amy P Abernethy, Michael S Broder, Charles L Shapiro, Anupama Kurup Acheson, Jennifer Malin, Tracey Evans, Monika K Krzyzanowska
PURPOSE: Integrated into routine oncology care, palliative care can improve symptom burden, quality of life, and patient and caregiver satisfaction. However, not all oncology practices have access to specialist palliative medicine. This project endeavored to define what constitutes high-quality primary palliative care as delivered by medical oncology practices. METHODS: An expert steering committee outlined 966 palliative care service items, in nine domains, each describing a candidate element of primary palliative care delivery for patients with advanced cancer or high symptom burden...
September 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27501720/caregiver-characteristics-and-bereavement-needs-findings-from-a-population-study
#20
Michelle DiGiacomo, Yutaka Hatano, Jane Phillips, Joanne Lewis, Amy P Abernethy, David C Currow
BACKGROUND: Globally, most care for people with life-limiting illnesses is provided by informal caregivers. Identifying characteristics of caregivers that may have unmet needs and negative outcomes can help provide better support to facilitate adjustment. AIM: We compared characteristics, expressed unmet needs and outcomes for spousal caregivers, with other caregivers at the end of life, by gender and age. DESIGN: The South Australian Health Omnibus is an annual, random, face-to-face, cross-sectional survey wherein respondents are asked about end-of-life care...
August 8, 2016: Palliative Medicine
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