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https://www.readbyqxmd.com/read/28651159/health-related-quality-of-life-results-from-the-phase-iii-checkmate-067-study
#1
Dirk Schadendorf, James Larkin, Jedd Wolchok, F Stephen Hodi, Vanna Chiarion-Sileni, Rene Gonzalez, Piotr Rutkowski, Jean-Jacques Grob, C Lance Cowey, Christopher Lao, John Wagstaff, Margaret K Callahan, Michael A Postow, Michael Smylie, Pier Francesco Ferrucci, Reinhard Dummer, Andrew Hill, Fiona Taylor, Javier Sabater, Dana Walker, Srividya Kotapati, Amy Abernethy, Georgina V Long
BACKGROUND: Nivolumab, a monoclonal antibody of immune checkpoint programmed death 1 on T cells (PD-1), combined with ipilimumab, an immune checkpoint cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor, as combination therapy on the one hand and nivolumab as monotherapy on the other, have both demonstrated improved efficacy compared with ipilimumab alone in the CheckMate 067 study. However, the combination resulted in a higher frequency of grade 3/4 adverse events (AEs), which could result in diminished health-related quality of life (HRQoL)...
June 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28646403/routine-ct-angiography-to-detect-severe-coronary-artery-disease-prior-to-transcatheter-aortic-valve-replacement
#2
S Chava, G Gentchos, A Abernethy, B Leavitt, E Terrien, H L Dauerman
Patients undergoing TAVR undergo routine CT angiography (CTA) to assess aorto-iliac pathology and annular dimensions. While coronary CTA may exclude severe CAD in younger patients, its efficacy in defining CAD severity prior to TAVR may be limited. We retrospectively studied 50 consecutive patients undergoing both invasive coronary angiography (ICA) and routine pre-TAVR CTA. Severe CAD was defined as ≥50% stenosis by quantitative coronary angiography and compared to a blinded CTA visual estimation of ≥50% stenosis...
June 23, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28644837/real-world-first-line-treatment-and-overall-survival-in-non-small-cell-lung-cancer-without-known-egfr-mutations-or-alk-rearrangements-in-us-community-oncology-setting
#3
Amy P Abernethy, Ashwini Arunachalam, Thomas Burke, Caroline McKay, Xiting Cao, Rachael Sorg, David P Carbone
PURPOSE: To establish a baseline for care and overall survival (OS) based upon contemporary first-line treatments prescribed in the era before the introduction of immune checkpoint inhibitors, for people with metastatic non-small cell lung cancer (NSCLC) without common actionable mutations. METHODS: Using a nationally representative electronic health record data from the Flatiron dataset which included 162 practices from different regions in US, we identified patients (≥18 years old) newly diagnosed with stage IV NSCLC initiating first-line anticancer therapy (November 2012- January 2015, with follow-up through July 2015)...
2017: PloS One
https://www.readbyqxmd.com/read/28643608/timothy-hillard-kathy-abernethy-haitham-hamoda-imogen-shaw-marian-everett-julie-ayres-and-heather-currie-management-of-the-menopause-6th-edn-british-menopause-society-marlow-uk-2017-180-pp-%C3%A2-20-pbk-isbn-978-0-9957398-0-2
#4
https://www.readbyqxmd.com/read/28628191/abiotic-and-biotic-factors-modulate-carrion-fate-and-vertebrate-scavenging-communities
#5
Kelsey L Turner, Erin F Abernethy, L Mike Conner, Olin E Rhodes, James C Beasley
Carrion is a valuable nutrient resource used by a diversity of vertebrates across the globe. However, vertebrate scavenging ecology remains an understudied area of science, especially in regards to how biotic and abiotic factors influence scavenging community composition. Here we elucidate how fundamental biotic and abiotic factors interact to modulate the efficiency and composition of vertebrate scavengers by investigating scavenging dynamics across a large gradient in carcass sizes and habitat types representative of many temperate ecosystems, as well as between two seasons reflecting differences in invertebrate activity...
June 19, 2017: Ecology
https://www.readbyqxmd.com/read/28627971/moving-on-factors-associated-with-caregivers-bereavement-adjustment-using-a-random-population-based-face-to-face-survey
#6
Emma Burns, Holly G Prigerson, Steve J Quinn, Amy P Abernethy, David C Currow
BACKGROUND: Providing care at end of life has consequences for caregivers' bereavement experience. 'Difficulty moving on with life' is an informative and unbiased symptom of prolonged grief disorder. Predictors of bereaved caregivers' ability to 'move on' have not been examined across the population. AIM: To identify the characteristics of bereaved hands-on caregivers who were, and were not, able to 'move on' 13-60 months after the 'expected' death of someone close...
June 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28598316/how-do-the-epidemiology-of-paediatric-methicillin-resistant-staphylococcus-aureus-and-methicillin-susceptible-staphylococcus-aureus-bacteraemia-differ
#7
Julia Abernethy, Mike Sharland, Alan P Johnson, Russell Hope
PURPOSE: To examine whether the epidemiology of bacteraemia caused by methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) differed in children aged <1 year and in comparison to older age groups. METHODOLOGY: English mandatory MRSA and MSSA surveillance data from 2006 and 2011, respectively, were collected. Epidemiological information was descriptively analysed in relation to methicillin susceptibility and patient age...
June 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28550069/incidence-and-prevalence-of-nmosd-in-australia-and-new-zealand
#8
Wajih Bukhari, Kerri M Prain, Patrick Waters, Mark Woodhall, Cullen M O'Gorman, Laura Clarke, Roger A Silvestrini, Christine S Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Matthew Brown, Wallace J Brownlee, Helmut Butzkueven, William M Carroll, Celia Chen, Alan Coulthard, Russell C Dale, Chandi Das, Keith Dear, Marzena J Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor Killpatrick, John King, Christopher Kneebone, Andrew J Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christpher Lynch, Richard Macdonell, Deborah F Mason, Pamela A McCombe, Michael P Pender, Jennifer A Pereira, John D Pollard, Stephen W Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie M Yiu, Michael H Barnett, Allan G Kermode, Mark P Marriott, John D E Parratt, Mark Slee, Bruce V Taylor, Ernest Willoughby, Robert J Wilson, Angela Vincent, Simon A Broadley
OBJECTIVES: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. BACKGROUND: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. METHODS: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD...
May 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28542031/septic-coronary-embolization-in-a-patient-with-congenitally-corrected-transposition-of-the-great-arteries
#9
Mehdi Rambod, Abraham D Abernethy, Prospero B Gogo, William E Hopkins
No abstract text is available yet for this article.
May 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28520522/perceptions-of-statin-discontinuation-among-patients-with-life-limiting-illness
#10
Jennifer Tjia, Jean S Kutner, Christine S Ritchie, Patrick J Blatchford, Rachael E Bennett Kendrick, Maryjo Prince-Paul, Tamara J Somers, Mary Lynn McPherson, Jeff A Sloan, Amy P Abernethy, Jon P Furuno
BACKGROUND: Optimal management of chronic medications for patients with life-limiting illness is uncertain. Medication deprescribing may improve outcomes in this population, but patient concerns regarding deprescribing are unclear. OBJECTIVE: The aim of this study was to quantify the perceived benefits and concerns of statin discontinuation among patients with life-limiting illness. DESIGN: Baseline data from a multicenter, pragmatic clinical trial of statin discontinuation were used...
May 18, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28505600/god-imagery-and-affective-outcomes-in-a-spiritually-integrative-inpatient-program
#11
Joseph M Currier, Joshua D Foster, Alexis D Abernethy, Charlotte V O Witvliet, Lindsey M Root Luna, Katharine M Putman, Sarah A Schnitker, Karl VanHarn, Janet Carter
Religion and/or spirituality (R/S) can play a vital, multifaceted role in mental health. While beliefs about God represent the core of many psychiatric patients' meaning systems, research has not examined how internalized images of the divine might contribute to outcomes in treatment programs/settings that emphasize multicultural sensitivity with R/S. Drawing on a combination of qualitative and quantitative information with a religiously heterogeneous sample of 241 adults who completed a spiritually integrative inpatient program over a two-year period, this study tested direct/indirect associations between imagery of how God views oneself, religious comforts and strains, and affective outcomes (positive and negative)...
May 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28502889/three-dimensional-printing-facilitates-successful-endovascular-closure-of-a-type-ii-abernethy-malformation-using-an-amplatzer-atrial-septal-occluder-device
#12
Jeffrey Forris Beecham Chick, Shilpa N Reddy, Alice C Yu, Tatiana Kelil, Ravi N Srinivasa, Kyle J Cooper, Wael E Saad
Type II Abernethy malformations, characterized by side-to-side portosystemic shunting with preserved intrahepatic portal venous system, have been treated with shunt closure surgically and endovascularly. Three-dimensional printing has been used to develop highly accurate patient-specific representations for surgical and endovascular planning and intervention. This innovation describes three-dimensional printing to successfully close a flush-oriented type II Abernethy malformation, with discrepant dimensions on computed tomography, conventional venography, and intravascular ultrasound, using a 12-mm AMPLATZER atrial septal occluder device...
May 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28472437/romana-3-a-phase-3-safety-extension-study-of-anamorelin-in-advanced-non-small-cell-lung-cancer-nsclc-patients-with-cachexia
#13
D Currow, J S Temel, A Abernethy, J Milanowski, J Friend, K C Fearon
Background: HASH(0x3320730) Patients and methods: HASH(0x331fe18) Results: HASH(0x2d4fd80) Conclusion: HASH(0x331c580) Clinical trial registration numbers: HASH(0x3316640)
May 4, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28469412/use-of-biomedical-ontologies-for-integration-of-biological-knowledge-for-learning-and-prediction-of-adverse-drug-reactions
#14
REVIEW
Shadia Zaman, Sirarat Sarntivijai, Darrell R Abernethy
Drug-induced toxicity is a major public health concern that leads to patient morbidity and mortality. To address this problem, the Food and Drug Administration is working on the PredicTox initiative, a pilot research program on tyrosine kinase inhibitors, to build mechanistic and predictive models for drug-induced toxicity. This program involves integrating data acquired during preclinical studies and clinical trials within pharmaceutical company development programs that they have agreed to put in the public domain and in publicly available biological, pharmacological, and chemical databases...
2017: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/28456729/in%C3%A2-vitro-in%C3%A2-vivo-extrapolation-of-metabolism-and-transporter-mediated-drug-drug-interactions-overview-of-basic-prediction-methods
#15
Kenta Yoshida, Ping Zhao, Lei Zhang, Darrell R Abernethy, Dinko Rekić, Kellie S Reynolds, Aleksandra Galetin, Shiew-Mei Huang
Evaluation of drug-drug interaction (DDI) risk is vital to establish benefit-risk profiles of investigational new drugs during drug development. In vitro experiments are routinely conducted as an important first step to assess metabolism- and transporter-mediated DDI potential of investigational new drugs. Results from these experiments are interpreted, often with the aid of in vitro-in vivo extrapolation methods, to determine whether and how DDI should be evaluated clinically to provide the basis for proper DDI management strategies, including dosing recommendations, alternative therapies, or contraindications under various DDI scenarios and in different patient population...
April 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28426943/how-strong-is-the-evidence-for-using-blood-biomarkers-alone-to-screen-for-alcohol-consumption-during-pregnancy-a-systematic-review
#16
Helen Howlett, Sarah Abernethy, Nigel W Brown, Judith Rankin, William K Gray
Accurate and early identification of women at risk from alcohol consumption during pregnancy allows education and support programmes to be targeted at those most in need. We aimed to conduct a systematic review to compare the efficacy of blood analysis and maternal self-report in detecting at risk women during pregnancy. This review investigated diagnostic accuracy. We searched four databases (Medline, Embase, Psychinfo and CINAHL) for relevant articles and conducted hand searches of recent issues of key journals in the field...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28425418/recurrent-hyperammonemia-after-abernethy-malformation-type-2-closure-a-case-report
#17
Hui Li, Zhi Ma, Ying Xie, Feng Tian
The Abernethy malformation is a rare congenital malformation defined by the presence of an extrahepatic portosystemic shunt. Although most patients are asymptomatic, clinical encephalopathy is present in 15% of cases. We present a patient with type 2 Abernethy malformation, hyperammonemia, and encephalopathy. Shunt closure was performed successfully using interventional angiography; however, hyperammonemia recurred 3 months later. The diagnosis of Abernethy malformation can be made easily, but the ideal patient management strategy has not yet been established...
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28410536/the-influence-of-ball-swing-on-the-timing-and-coordination-of-a-natural-interceptive-task
#18
Vishnu Sarpeshkar, David L Mann, Wayne Spratford, Bruce Abernethy
Successful interception relies on the use of perceptual information to accurately guide an efficient movement strategy that allows performers to be placed at the right place at the right time. Although previous studies have highlighted the differences in the timing and coordination of movement that underpin interceptive expertise, very little is known about how these movement patterns are adapted when intercepting targets that follow a curvilinear flight-path. The aim of this study was to examine how curvilinear ball-trajectories influence movement patterns when intercepting a fast-moving target...
April 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28408335/optimizing-delivery-of-a-behavioral-pain-intervention-in-cancer-patients-using-a-sequential-multiple-assignment-randomized-trial-smart
#19
Sarah A Kelleher, Caroline S Dorfman, Jen C Plumb Vilardaga, Catherine Majestic, Joseph Winger, Vicky Gandhi, Christine Nunez, Alyssa Van Denburg, Rebecca A Shelby, Shelby D Reed, Susan Murphy, Marie Davidian, Eric B Laber, Gretchen G Kimmick, Kelly W Westbrook, Amy P Abernethy, Tamara J Somers
BACKGROUND/AIMS: Pain is common in cancer patients and results in lower quality of life, depression, poor physical functioning, financial difficulty, and decreased survival time. Behavioral pain interventions are effective and nonpharmacologic. Traditional randomized controlled trials (RCT) test interventions of fixed time and dose, which poorly represent successive treatment decisions in clinical practice. We utilize a novel approach to conduct a RCT, the sequential multiple assignment randomized trial (SMART) design, to provide comparative evidence of: 1) response to differing initial doses of a pain coping skills training (PCST) intervention and 2) intervention dose sequences adjusted based on patient response...
April 11, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28399109/tyrosine-kinase-targeting-drugs-associated-heart-failure
#20
N Gronich, I Lavi, O Barnett-Griness, W Saliba, D R Abernethy, G Rennert
BACKGROUND: The impact of cancer therapies on cardiac disease in the general adult cancer survivor population is largely unknown. Our objective was to evaluate which tyrosine kinase-targeting drugs are associated with greater risk for new-onset heart failure (HF). METHODS: A nested case-control analysis was conducted within a cohort of 27 992 patients of Clalit Health Services, newly treated with a tyrosine kinase-targeting, and/or chemotherapeutic drug, for a malignant disease, between 1 January 2005 and 31 December 2012...
May 9, 2017: British Journal of Cancer
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