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Kaartik Soota, Jagpal Singh Klair, Douglas LaBrecque
No abstract text is available yet for this article.
January 9, 2018: Clinical Gastroenterology and Hepatology
David J Greenblatt, Donald E Mager, Bernd Meibohm, Gilbert J Burckart
No abstract text is available yet for this article.
February 2018: Clinical Pharmacology in Drug Development
David J Greenblatt, Donald E Mager, Bernd Meibohm, Gilbert J Burckart
No abstract text is available yet for this article.
February 2018: Journal of Clinical Pharmacology
Sean Khozin, Amy P Abernethy, Nathan C Nussbaum, Jizu Zhi, Melissa D Curtis, Melisa Tucker, Shannon E Lee, David E Light, Anala Gossai, Rachael A Sorg, Aracelis Z Torres, Payal Patel, Gideon Michael Blumenthal, Richard Pazdur
BACKGROUND: Evidence from cancer clinical trials can be difficult to generalize to real-world patient populations, but can be complemented by real-world evidence to optimize personalization of care. Further, real-world usage patterns of programmed cell death protein 1 (PD-1) inhibitors following approval can inform future studies of subpopulations underrepresented in clinical trials. MATERIALS AND METHODS: We performed a multicenter analysis using electronic health record data collected during routine care of patients treated in community cancer care clinics in the Flatiron Health network...
January 9, 2018: Oncologist
Anne M Butler, Karynsa Cetin, Rohini K Hernandez, B Diane Reams, Robert A Overman, Jung I Kim, Bradford R Hirsch, Amy P Abernethy, Alexander Liede, M Alan Brookhart
PURPOSE: To examine the dynamics of treatment with 2 bone-targeting agents (BTAs)-denosumab and zoledronic acid-among men with bone metastases from prostate cancer. METHODS: Using electronic health record data from oncology practices across the US, we identified prostate cancer patients diagnosed with bone metastasis in 2012/2013 without evidence of BTA use within 6 months prior to diagnosis. We examined the risk and predictors of BTA initiation, interruption, and re-initiation...
January 7, 2018: Pharmacoepidemiology and Drug Safety
Emily A Courcier, Fraser D Menzies, Sam A J Strain, Robin A Skuce, Philip A Robinson, Ivan A P Patterson, Kathryn R McBride, Carl M McCormick, Eric Walton, Stanley W J McDowell, Darrell A Abernethy
No abstract text is available yet for this article.
December 22, 2017: Veterinary Record
Shannon H Abernethy
No abstract text is available yet for this article.
December 16, 2017: Journal of Pediatric Nursing
Joshua T Herbeck, Kathryn Peebles, Paul T Edlefsen, Morgane Rolland, James T Murphy, Geoffrey S Gottlieb, Neil Abernethy, James I Mullins, John E Mittler, Steven M Goodreau
BACKGROUND: Development of an HIV vaccine might be essential to ending the HIV/AIDS pandemic. However, vaccines can result in the emergence and spread of vaccine-resistant strains. Indeed, analyses of breakthrough infections in the HIV phase 3 vaccine trial RV144 identified HIV genotypes with differential rates of transmission in vaccine and placebo recipients. We hypothesized that, for HIV vaccination programs based on partially effective vaccines similar to RV144, HIV adaptation will rapidly diminish the expected vaccine impact...
December 11, 2017: Vaccine
Albert Lee, Diego Eifer, Elsie T Nguyen
No abstract text is available yet for this article.
November 29, 2017: Journal of Cardiovascular Computed Tomography
Hamish A Jamieson, Prasad S Nishtala, Richard Scrase, Joanne M Deely, Rebecca Abey-Nesbit, Martin J Connolly, Sarah N Hilmer, Darrell R Abernethy, Philip J Schluter
BACKGROUND: Adverse outcomes associated with advanced diseases are often exacerbated by polypharmacy. OBJECTIVES: The current study investigated an association between exposure to anticholinergic and sedative medicines and falls in community-dwelling older people, after controlling for potential confounders. METHODS: We conducted a retrospective cross-sectional study of a continuously recruited national cohort of community-dwelling New Zealanders aged 65 years and over...
December 8, 2017: Drugs & Aging
Rebecca A Miksad, Amy P Abernethy
The role of real-world evidence (RWE) in regulatory, drug development, and healthcare decision-making is rapidly expanding. Recent advances have increased the complexity of cancer care and widened the gap between randomized clinical trial (RCT) results and the evidence needed for real-world clinical decisions. Instead of remaining invisible, data from the >95% of cancer patients treated outside of clinical trials can help fill this void.
December 6, 2017: Clinical Pharmacology and Therapeutics
Melanie Jessup, Wendy Smyth, Gail Abernethy, Linda Shields, Tonia Douglas
AIMS AND OBJECTIVES: This study aimed to explore experience of family-centred care among parents of children with cystic fibrosis living far from tertiary treatment centres and to understand what such distances mean to their care. BACKGROUND: Australia is a large continent. However, many families with a child with cystic fibrosis live in regional areas, often thousands of kilometres away from the primary treatment centres located in Australia's coastal capital cities...
October 19, 2017: Journal of Clinical Nursing
Adam D Gorman, Bruce Abernethy, Damian Farrow
The anticipatory memory encodings of expert and novice basketball players were examined under conditions of both full (attended condition) and reduced (unattended condition) attention (see also Gorman, Abernethy, & Farrow in Attention, Perception, & Psychophysics, 75, 835-844, 2013a). Participants completed a typical pattern recall task using dynamic playing sequences from basketball, and their responses were compared to both the original target pattern as well as to the series of patterns that occurred immediately after and immediately before the target image...
October 16, 2017: Attention, Perception & Psychophysics
S W Johnny Lau, Jan-Frederik Schlender, Darrell R Abernethy, Gilbert J Burckart, Adam Golden, Patricia W Slattum, Sven Stegemann, Thomas Eissing
No abstract text is available yet for this article.
October 11, 2017: Journal of Clinical Pharmacology
Thomas W LeBlanc, Amy P Abernethy
Recording of patient-reported outcomes (PROs) enables direct measurement of the experiences of patients with cancer. In the past decade, the use of PROs has become a prominent topic in health-care innovation; this trend highlights the role of the patient experience as a key measure of health-care quality. Historically, PROs were used solely in the context of research studies, but a growing body of literature supports the feasibility of electronic collection of PROs, yielding reliable data that are sometimes of better quality than clinician-reported data...
December 2017: Nature Reviews. Clinical Oncology
Vishnu Sarpeshkar, Bruce Abernethy, David L Mann
It is well known that skilled batters in fast-ball sports do not align their gaze with the ball throughout ball-flight, but instead adopt a unique sequence of eye and head movements that contribute toward their skill. However, much of what we know about visual-motor behavior in hitting is based on studies that have employed case study designs, and/or used simplified tasks that fall short of replicating the spatiotemporal demands experienced in the natural environment. The aim of this study was to provide a comprehensive examination of the eye and head movement strategies that underpin the development of visual-motor expertise when intercepting a fast-moving target...
October 2017: Journal of Experimental Psychology. Human Perception and Performance
P Bastiaensen, D Abernethy, E Etter
African countries that wish to export are increasingly faced with import risk assessments from importing countries concerned about the sources of their imported goods. Other risk analysis methodologies and approaches are also employed, which focus on animal and human health within countries and communities. Based on an analysis of evaluations conducted by the World Organisation for Animal Health (OIE), using the Performance of Veterinary Services Tool, the authors attempt to define current practice in Africa and degrees of compliance with the World Trade Organization Agreement on the Application of Sanitary and Phytosanitary Measures ('SPS Agreement') and OIE standards...
April 2017: Revue Scientifique et Technique
Xiao-Lin Zhang, Xiao-Min Duan, Fang-Yun Wang, Xin Zhang, Yan Sun, Ning Ma, Zhong-Dong Du
No abstract text is available yet for this article.
September 20, 2017: Chinese Medical Journal
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