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https://www.readbyqxmd.com/read/29756355/development-and-validation-of-a-high-quality-composite-real-world-mortality-endpoint
#1
Melissa D Curtis, Sandra D Griffith, Melisa Tucker, Michael D Taylor, William B Capra, Gillis Carrigan, Ben Holzman, Aracelis Z Torres, Paul You, Brandon Arnieri, Amy P Abernethy
OBJECTIVE: To create a high-quality electronic health record (EHR)-derived mortality dataset for retrospective and prospective real-world evidence generation. DATA SOURCES/STUDY SETTING: Oncology EHR data, supplemented with external commercial and US Social Security Death Index data, benchmarked to the National Death Index (NDI). STUDY DESIGN: We developed a recent, linkable, high-quality mortality variable amalgamated from multiple data sources to supplement EHR data, benchmarked against the highest completeness U...
May 14, 2018: Health Services Research
https://www.readbyqxmd.com/read/29744090/stepwise-management-of-hepatocellular-carcinoma-associated-with-abernethy-syndrome
#2
Niki Christou, Nabil Dib, Etienne Chuffart, Abdelkader Taibi, Sylvaine Durand-Fontanier, Denis Valleix, Muriel Mathonnet
Patients with congenital agenesis of the portal vein may develop hepatocellular tumors due to enhanced arterial blood flow. These tumors may be benign (FNH, adenomas) or malignant (hepatoblastoma, HCC). Liver resection can be proposed, and preoperative arterial embolization may decrease blood loss during surgery. Liver transplantation with PV reconstruction is also an option.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29739575/lipid-oxidation-and-vitamin-d3-degradation-in-simulated-whole-milk-powder-as-influenced-by-processing-and-storage
#3
Fatemeh Mahmoodani, Conrad O Perera, Grant Abernethy, Bruno Fedrizzi, Hong Chen
Vitamin D3 levels are known to sometimes decline in fortified products, which could be due to its degradation, although the exact mechanism is unknown. In this study, the influence of processing and storage conditions on lipid oxidation and vitamin D3 degradation were studied. Simulated whole milk powders with and without heat treatment were stored for 12 months at two different storage temperatures (20 °C and 40 °C). Stored samples without heat treatment showed higher lipid oxidation products analyzed by PV and TBARS values compared to those with heat treatment...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29733723/real-world-evidence-in-support-of-precision-medicine-clinico-genomic-cancer-data-as-a-case-study
#4
Vineeta Agarwala, Sean Khozin, Gaurav Singal, Claire O'Connell, Deborah Kuk, Gerald Li, Anala Gossai, Vincent Miller, Amy P Abernethy
The majority of US adult cancer patients today are diagnosed and treated outside the context of any clinical trial (that is, in the real world). Although these patients are not part of a research study, their clinical data are still recorded. Indeed, data captured in electronic health records form an ever-growing, rich digital repository of longitudinal patient experiences, treatments, and outcomes. Likewise, genomic data from tumor molecular profiling are increasingly guiding oncology care. Linking real-world clinical and genomic data, as well as information from other co-occurring data sets, could create study populations that provide generalizable evidence for precision medicine interventions...
May 2018: Health Affairs
https://www.readbyqxmd.com/read/29675774/radioembolization-for-hepatocellular-carcinoma-arising-in-the-setting-of-a-congenital-extrahepatic-portosystemic-shunt-abernethy-malformation
#5
Thomas Kroencke, Marcus Murnauer, Frank Alexander Jordan, Vera Blodow, Hannes Ruhnke, Tina Schaller, Bruno Märkl
In a 50-year-old male with an incidentally discovered hepatocellular carcinoma, a congenital extrahepatic portosystemic shunt with the absence of the portal vein (Abernethy syndrome) was diagnosed by imaging. This study aims to discuss the variant anatomy relevant to this splanchnic vascular malformation, review its association with the development of liver neoplasms, and report the safety and efficacy of TARE followed by resection for a HCC arising in this rare condition.
April 19, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29650706/pro-inflammatory-biomarkers-in-stable-versus-acutely-decompensated-heart-failure-with-preserved-ejection-fraction
#6
Abraham Abernethy, Sadi Raza, Jie-Lena Sun, Kevin J Anstrom, Russell Tracy, Johannes Steiner, Peter VanBuren, Martin M LeWinter
BACKGROUND: Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction (HFpEF). In this study we tested the hypothesis that pro-inflammatory biomarkers are elevated in patients with acutely decompensated HFpEF (AD-HFpEF) compared with patients with stable HFpEF (S-HFpEF). METHODS AND RESULTS: Using a post hoc analysis the serum biomarkers tumor necrosis factor-alpha, high-sensitivity C-reactive protein interleukin 6 and pentraxin 3 (PTX3) and clinical, demographic, echocardiographic-Doppler and clinical outcomes data were analyzed in HFpEF patients enrolled in NHLBI Heart Failure Research Network clinical trials which enrolled patients with either AD-HFpEF or S-HFpEF...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29649384/response-to-davis-and-behm-doi-10-1089-jpm-2017-0608-discontinuation-of-statins
#7
Christine S Ritchie, Jean S Kutner, Patrick J Blatchford, Amy P Abernethy
No abstract text is available yet for this article.
March 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29643104/actigraphy-assessment-of-sleep-quality-among-patients-with-acute-myeloid-leukaemia-during-induction-chemotherapy
#8
Chi-Fu Jeffrey Yang, Kelli Aibel, Ryan Meyerhoff, Frances Wang, David Harpole, Amy P Abernethy, Thomas W LeBlanc
OBJECTIVES: Patients receiving induction chemotherapy for acute myeloid leukaemia (AML) anecdotally describe poor sleep, but sleep disturbances have not been well-characterised in this population. We aimed to test the feasibility of measuring sleep quality in AML inpatients using a wearable actigraphy device. METHODS: Using the Actigraph GT3X 'watch', we assessed the total sleep time, sleep onset latency, wake after sleep onset, number of awakenings after sleep onset and sleep efficiency for inpatients with AML receiving induction chemotherapy...
April 11, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29556928/identification-of-vitamin-d3-oxidation-products-using-high-resolution-and-tandem-mass-spectrometry
#9
Fatemeh Mahmoodani, Conrad O Perera, Grant Abernethy, Bruno Fedrizzi, David Greenwood, Hong Chen
In a successful fortification program, the stability of micronutrients added to the food is one of the most important factors. The added vitamin D3 is known to sometimes decline during storage of fortified milks, and oxidation through fatty acid lipoxidation could be suspected as the likely cause. Identification of vitamin D3 oxidation products (VDOPs) in natural foods is a challenge due to the low amount of their contents and their possible transformation to other compounds during analysis. The main objective of this study was to find a method to extract VDOPs in simulated whole milk powder and to identify these products using LTQ-ion trap, Q-Exactive Orbitrap and triple quadrupole mass spectrometry...
March 19, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29555620/an-mhealth-pain-coping-skills-training-intervention-for-hematopoietic-stem-cell-transplantation-patients-development-and-pilot-randomized-controlled-trial
#10
Tamara J Somers, Sarah A Kelleher, Caroline S Dorfman, Rebecca A Shelby, Hannah M Fisher, Krista Rowe Nichols, Keith M Sullivan, Nelson J Chao, Gregory P Samsa, Amy P Abernethy, Francis J Keefe
BACKGROUND: Pain is a challenge for patients following hematopoietic stem cell transplantation (HCT). OBJECTIVE: This study aimed to develop and test the feasibility, acceptability, and initial efficacy of a Web-based mobile pain coping skills training (mPCST) protocol designed to address the needs of HCT patients. METHODS: Participants had undergone HCT and reported pain following transplant (N=68). To guide intervention development, qualitative data were collected from focus group participants (n=25) and participants who completed user testing (n=7)...
March 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29523665/patient-reported-distress-in-myelodysplastic-syndromes-and-its-association-with-clinical-outcomes-a-retrospective-cohort-study
#11
Jesse D Troy, Carlos M de Castro, Mary Ruth Pupa, Greg P Samsa, Amy P Abernethy, Thomas W LeBlanc
Background: NCCN defines distress as a multifactorial, unpleasant emotional experience of a psychological nature that may interfere with patients' ability to cope with cancer symptoms and treatment. Patients with myelodysplastic syndromes (MDS) are at risk for distress due to the largely incurable nature of this hematopoietic malignancy and its symptom burden, yet associations with clinical outcomes are unknown. Methods: We retrospectively reviewed patient-reported distress data from adult ambulatory patients with MDS visiting a single, tertiary care medical center from July 2013 to September 2015...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29518666/catastrophic-intraoperative-bleeding-due-to-congenital-extrahepatic-porto-systemic-shunt-anomaly-a-surgical-case-report-of-two-rare-anomalies
#12
Ali Mohtashami, Andrew Kiat, Jane Cross, Robert Simon, Austin Curtin
INTRODUCTION: Abernethy malformations are extremely rare congenital anomalous portosystemic shunts. We report the case of a patient with a rare variant Abernethy malformation between the superior mesenteric vein and left renal vein, associated with a massive jejunal diverticulum. PRESENTATION OF CASE: A 37-year-old Caucasian female presented to our emergency department with severe abdominal pain and proceeded to laparotomy for a presumed small bowel obstruction...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29468037/single-nucleotide-polymorphism-discovery-and-panel-characterization-in-the-african-forest-elephant
#13
Stéphanie Bourgeois, Helen Senn, Jenny Kaden, John B Taggart, Rob Ogden, Kathryn J Jeffery, Nils Bunnefeld, Katharine Abernethy, Ross McEwing
The continuing decline in forest elephant ( Loxodonta cyclotis ) numbers due to poaching and habitat reduction is driving the search for new tools to inform management and conservation. For dense rainforest species, basic ecological data on populations and threats can be challenging and expensive to collect, impeding conservation action in the field. As such, genetic monitoring is being increasingly implemented to complement or replace more burdensome field techniques. Single-nucleotide polymorphisms (SNPs) are particularly cost-effective and informative markers that can be used for a range of practical applications, including population census, assessment of human impact on social and genetic structure, and investigation of the illegal wildlife trade...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29463344/haemodynamic-consequences-following-closure-of-an-abernethy-malformation-in-a-patient-following-a-total-cavopulmonary-shunt
#14
Deepa Sasikumar, Bijulal Sasidharan, Anoop Ayyappan
A 17-year-old girl with situs ambiguous, hypoplastic right ventricle with a large ventricular septal defect, and severe pulmonary stenosis had undergone Kawashima operation 10 years back. She had significant desaturation because of a large Abernethy malformation, with reverse shunting from the inferior caval vein to the portal vein. It was closed with a vascular plug, with improvement in oxygen saturation. She developed extensive inferior caval vein thrombus following the procedure, which was managed conservatively by anti-coagulation...
May 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29460065/the-impact-of-intraoperative-magnetic-resonance-in-routine-pediatric-neurosurgical-practice-a-6-year-appraisal
#15
Sonia Tejada, Shivaram Avula, Benedetta Pettorini, Dawn Henningan, Laurence Abernethy, Conor Mallucci
BACKGROUND: The intraoperative magnetic resonance scanner (ioMR) was introduced in our unit in 2009, and has been used routinely since then. OBJECTIVE: This study aims to describe indications, radiological features, and clinical outcomes of the patients operated on with ioMRI and analyze our experience. METHODS: A retrospective analysis of a prospective surgical database has been performed, including surgical procedure, intent, radiological reports, need for second-look surgery, and complications, supplemented by further review of the clinical notes and the scans...
April 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29447208/species-specific-regulation-of-angiogenesis-by-glucocorticoids-reveals-contrasting-effects-on-inflammatory-and-angiogenic-pathways
#16
Ruth Morgan, John Keen, Daniel Halligan, Alan O'Callaghan, Ruth Andrew, Dawn Livingstone, Amber Abernethie, Giorgia Maltese, Brian Walker, Patrick Hadoke
Glucocorticoids are potent inhibitors of angiogenesis in the rodent in vivo and in vitro but the mechanism by which this occurs has not been determined. Administration of glucocorticoids is used to treat a number of conditions in horses but the angiogenic response of equine vessels to glucocorticoids and, therefore, the potential role of glucocorticoids in pathogenesis and treatment of equine disease, is unknown. This study addressed the hypothesis that glucocorticoids would be angiostatic both in equine and murine blood vessels...
2018: PloS One
https://www.readbyqxmd.com/read/29435985/farewell-to-our-good-friend-outstanding-mentor-and-colleague-darrell-r-abernethy-1949-2017
#17
Janice B Schwartz, Raymond L Woosley, Carl C Peck
No abstract text is available yet for this article.
April 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29433921/modified-perceptual-training-in-sport-a-new-classification-framework
#18
REVIEW
Stephen Mark Hadlow, Derek Panchuk, David Lindsay Mann, Marc Ronald Portus, Bruce Abernethy
OBJECTIVES: To overview a framework that provides a theoretically-grounded approach to predicting the types of modified perceptual training tasks that will stimulate transfer of improved perceptual skills to sport performance environments. Modified perceptual training (MPT) collectively describes on- or off-field sports training tasks that are specifically designed to develop visual and perceptual-cognitive skill. Traditional training approaches in sport include sports vision training and perceptual-cognitive training, while recently, new technologies have enabled a broad range of additional MPT tools to become available to coaches and athletes...
February 3, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29420142/the-surprise-question-and-identification-of-palliative-care-needs-among-hospitalized-patients-with-advanced-hematologic-or-solid-malignancies
#19
Kathryn Elizabeth Hudson, Steven Paul Wolf, Gregory P Samsa, Arif H Kamal, Amy Pickar Abernethy, Thomas William LeBlanc
BACKGROUND: Little is known about quality of life (QOL), depression, and end-of-life (EOL) outcomes among hospitalized patients with advanced cancer. OBJECTIVE: To assess whether the surprise question identifies inpatients with advanced cancer likely to have unmet palliative care needs. DESIGN: Prospective cohort study and long-term follow-up. SETTING/SUBJECTS: From 2008 to 2010, we enrolled 150 inpatients at Duke University with stage III/IV solid tumors or lymphoma/acute leukemia and whose physician would not be surprised if they died in less than one year...
February 8, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29417756/darrell-r-abernethy-1949-2017
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Pharmacology Research & Perspectives
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