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Fatemeh Mahmoodani, Conrad O Perera, Grant Abernethy, Bruno Fedrizzi, David Greenwood, Hong Chen
In a successful fortification program, the stability of micronutrients added to the food is one of the most important factors. The added vitamin D3 is known to sometimes decline during storage of fortified milks, and oxidation through fatty acid lipoxidation could be suspected as the likely cause. Identification of vitamin D3 oxidation products (VDOPs) in natural foods is a challenge due to the low amount of their contents and their possible transformation to other compounds during analysis. The main objective of this study was to find a method to extract VDOPs in simulated whole milk powder and to identify these products using LTQ-ion trap, Q-Exactive Orbitrap and triple quadrupole mass spectrometry...
March 19, 2018: Journal of the American Society for Mass Spectrometry
Tamara J Somers, Sarah A Kelleher, Caroline S Dorfman, Rebecca A Shelby, Hannah M Fisher, Krista Rowe Nichols, Keith M Sullivan, Nelson J Chao, Gregory P Samsa, Amy P Abernethy, Francis J Keefe
BACKGROUND: Pain is a challenge for patients following hematopoietic stem cell transplantation (HCT). OBJECTIVE: This study aimed to develop and test the feasibility, acceptability, and initial efficacy of a Web-based mobile pain coping skills training (mPCST) protocol designed to address the needs of HCT patients. METHODS: Participants had undergone HCT and reported pain following transplant (N=68). To guide intervention development, qualitative data were collected from focus group participants (n=25) and participants who completed user testing (n=7)...
March 19, 2018: JMIR MHealth and UHealth
Jesse D Troy, Carlos M de Castro, Mary Ruth Pupa, Greg P Samsa, Amy P Abernethy, Thomas W LeBlanc
Background: NCCN defines distress as a multifactorial, unpleasant emotional experience of a psychological nature that may interfere with patients' ability to cope with cancer symptoms and treatment. Patients with myelodysplastic syndromes (MDS) are at risk for distress due to the largely incurable nature of this hematopoietic malignancy and its symptom burden, yet associations with clinical outcomes are unknown. Methods: We retrospectively reviewed patient-reported distress data from adult ambulatory patients with MDS visiting a single, tertiary care medical center from July 2013 to September 2015...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Ali Mohtashami, Andrew Kiat, Jane Cross, Robert Simon, Austin Curtin
INTRODUCTION: Abernethy malformations are extremely rare congenital anomalous portosystemic shunts. We report the case of a patient with a rare variant Abernethy malformation between the superior mesenteric vein and left renal vein, associated with a massive jejunal diverticulum. PRESENTATION OF CASE: A 37-year-old Caucasian female presented to our emergency department with severe abdominal pain and proceeded to laparotomy for a presumed small bowel obstruction...
February 27, 2018: International Journal of Surgery Case Reports
Stéphanie Bourgeois, Helen Senn, Jenny Kaden, John B Taggart, Rob Ogden, Kathryn J Jeffery, Nils Bunnefeld, Katharine Abernethy, Ross McEwing
The continuing decline in forest elephant ( Loxodonta cyclotis ) numbers due to poaching and habitat reduction is driving the search for new tools to inform management and conservation. For dense rainforest species, basic ecological data on populations and threats can be challenging and expensive to collect, impeding conservation action in the field. As such, genetic monitoring is being increasingly implemented to complement or replace more burdensome field techniques. Single-nucleotide polymorphisms (SNPs) are particularly cost-effective and informative markers that can be used for a range of practical applications, including population census, assessment of human impact on social and genetic structure, and investigation of the illegal wildlife trade...
February 2018: Ecology and Evolution
Deepa Sasikumar, Bijulal Sasidharan, Anoop Ayyappan
A 17-year-old girl with situs ambiguous, hypoplastic right ventricle with a large ventricular septal defect, and severe pulmonary stenosis had undergone Kawashima operation 10 years back. She had significant desaturation because of a large Abernethy malformation, with reverse shunting from the inferior caval vein to the portal vein. It was closed with a vascular plug, with improvement in oxygen saturation. She developed extensive inferior caval vein thrombus following the procedure, which was managed conservatively by anti-coagulation...
February 21, 2018: Cardiology in the Young
Sonia Tejada, Shivaram Avula, Benedetta Pettorini, Dawn Henningan, Laurence Abernethy, Conor Mallucci
BACKGROUND: The intraoperative magnetic resonance scanner (ioMR) was introduced in our unit in 2009, and has been used routinely since then. OBJECTIVE: This study aims to describe indications, radiological features, and clinical outcomes of the patients operated on with ioMRI and analyze our experience. METHODS: A retrospective analysis of a prospective surgical database has been performed, including surgical procedure, intent, radiological reports, need for second-look surgery, and complications, supplemented by further review of the clinical notes and the scans...
February 19, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ruth Morgan, John Keen, Daniel Halligan, Alan O'Callaghan, Ruth Andrew, Dawn Livingstone, Amber Abernethie, Giorgia Maltese, Brian Walker, Patrick Hadoke
Glucocorticoids are potent inhibitors of angiogenesis in the rodent in vivo and in vitro but the mechanism by which this occurs has not been determined. Administration of glucocorticoids is used to treat a number of conditions in horses but the angiogenic response of equine vessels to glucocorticoids and, therefore, the potential role of glucocorticoids in pathogenesis and treatment of equine disease, is unknown. This study addressed the hypothesis that glucocorticoids would be angiostatic both in equine and murine blood vessels...
2018: PloS One
Janice B Schwartz, Raymond L Woosley, Carl C Peck
No abstract text is available yet for this article.
February 13, 2018: Clinical Pharmacology and Therapeutics
Stephen Mark Hadlow, Derek Panchuk, David Lindsay Mann, Marc Ronald Portus, Bruce Abernethy
OBJECTIVES: To overview a framework that provides a theoretically-grounded approach to predicting the types of modified perceptual training tasks that will stimulate transfer of improved perceptual skills to sport performance environments. Modified perceptual training (MPT) collectively describes on- or off-field sports training tasks that are specifically designed to develop visual and perceptual-cognitive skill. Traditional training approaches in sport include sports vision training and perceptual-cognitive training, while recently, new technologies have enabled a broad range of additional MPT tools to become available to coaches and athletes...
February 3, 2018: Journal of Science and Medicine in Sport
Kathryn Elizabeth Hudson, Steven Paul Wolf, Gregory P Samsa, Arif H Kamal, Amy Pickar Abernethy, Thomas William LeBlanc
BACKGROUND: Little is known about quality of life (QOL), depression, and end-of-life (EOL) outcomes among hospitalized patients with advanced cancer. OBJECTIVE: To assess whether the surprise question identifies inpatients with advanced cancer likely to have unmet palliative care needs. DESIGN: Prospective cohort study and long-term follow-up. SETTING/SUBJECTS: From 2008 to 2010, we enrolled 150 inpatients at Duke University with stage III/IV solid tumors or lymphoma/acute leukemia and whose physician would not be surprised if they died in less than one year...
February 8, 2018: Journal of Palliative Medicine
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Pharmacology Research & Perspectives
Alexander Liede, Sally Wade, Jan Lethen, Rohini K Hernandez, Douglas Warner, Amy P Abernethy, Antonio Finelli
PURPOSE: This observational study of oncologic clinical practices was designed to describe real-world patterns of use of emerging therapies (abiraterone acetate, cabazitaxel, enzalutamide, radium-223, sipuleucel-T) in patients with castration-resistant prostate cancer and to characterize their concomitant use with denosumab or zoledronic acid. METHODS: A retrospective cohort study was conducted using a database of electronic health records from oncology practices across the United States...
January 24, 2018: Clinical Therapeutics
Sara H Downs, Jessica E Parry, Paul A Upton, Jennifer M Broughan, Anthony V Goodchild, Javier Nuñez-Garcia, Matthias Greiner, Darrell A Abernethy, Angus R Cameron, Alasdair J Cook, Ricardo de la Rua-Domenech, Jane Gunn, Elizabeth Pritchard, Shelley Rhodes, Simon Rolfe, Michael Sharp, H Martin Vordermeier, Eamon Watson, Michael Welsh, Adam O Whelan, John A Woolliams, Simon J More, Richard S Clifton-Hadley
A systematic review was conducted to identify studies with data for statistical meta-analyses of sensitivity (Se) and specificity (Sp) of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis (bTB) in cattle. Members of a working group (WG) developed and tested search criteria and developed a standardised two-stage review process, to identify primary studies with numerator and denominator data for test performance and an agreed range of covariate data. No limits were applied to year, language, region or type of test in initial searches of electronic databases...
November 9, 2017: Preventive Veterinary Medicine
Kee Yong Wong, Ram Jeeneea, Andrew Healey, Laurence Abernethy, Harriet Corbett, Fiona McAndrew, Paul Losty
INTRODUCTION: To report the management and outcome of paediatric patients sustaining high grade blunt renal trauma. PATIENTS AND METHODS: Medical records were examined for all Grade III to Grade V blunt renal trauma cases admitted to a paediatric trauma centre during the era(s) 2005 to 2015. Data collected and analysed included - demographics, imaging modalities, management, length of hospital stay, complications and follow-up outcome(s). RESULTS: 18 children (12 males, 6 females) with mean age 11 years (4 - 15) were included...
January 23, 2018: BJU International
Daniel Bonnar, Kate Bartel, Naomi Kakoschke, Christin Lang
BACKGROUND: Athletes experience various situations and conditions that can interfere with their sleep, which is crucial for optimal psychological and physiological recovery as well as subsequent performance. Conventional sleep screening and intervention approaches may not be efficacious for athletes given their lifestyle, the demands of training and travel associated with interstate/international competition. OBJECTIVES: The present systematic review aimed to summarize and evaluate sleep intervention studies targeting subsequent performance and recovery in competitive athletes...
January 20, 2018: Sports Medicine
Kaartik Soota, Jagpal Singh Klair, Douglas LaBrecque
No abstract text is available yet for this article.
January 9, 2018: Clinical Gastroenterology and Hepatology
David J Greenblatt, Donald E Mager, Bernd Meibohm, Gilbert J Burckart
No abstract text is available yet for this article.
February 2018: Clinical Pharmacology in Drug Development
David J Greenblatt, Donald E Mager, Bernd Meibohm, Gilbert J Burckart
No abstract text is available yet for this article.
February 2018: Journal of Clinical Pharmacology
Sean Khozin, Amy P Abernethy, Nathan C Nussbaum, Jizu Zhi, Melissa D Curtis, Melisa Tucker, Shannon E Lee, David E Light, Anala Gossai, Rachael A Sorg, Aracelis Z Torres, Payal Patel, Gideon Michael Blumenthal, Richard Pazdur
BACKGROUND: Evidence from cancer clinical trials can be difficult to generalize to real-world patient populations, but can be complemented by real-world evidence to optimize personalization of care. Further, real-world usage patterns of programmed cell death protein 1 (PD-1) inhibitors following approval can inform future studies of subpopulations underrepresented in clinical trials. MATERIALS AND METHODS: We performed a multicenter analysis using electronic health record data collected during routine care of patients treated in community cancer care clinics in the Flatiron Health network...
January 9, 2018: Oncologist
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