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Issam Zineh, Darrell Abernethy, Cornelis E C A Hop, Akintunde Bello, Mark B McClellan, Gregory W Daniel, Morgan H Romine
No abstract text is available yet for this article.
October 11, 2016: Clinical Pharmacology and Therapeutics
Sharon A Allen, Eleonora Dal Grande, Amy P Abernethy, David C Currow
BACKGROUND: Chronic pain interfering with activities of daily living is highly prevalent in the community. More than 600 million people worldwide are obese. The aim of this paper is to assess if such chronic pain is associated independently with obesity across the adult population, having controlled for other key factors. METHODS: The South Australian Health Omnibus is an annual, population-based, cross-sectional study. Data on 2616 participants were analysed for episodes of daily pain for three of the preceding six months...
September 30, 2016: BMC Public Health
Elizabeth A Nardi, Lisa Korin Lentz, Katherine Winckworth-Prejsnar, Amy P Abernethy, Robert W Carlson
When used effectively, health information technology (HIT) can transform clinical care and contribute to new research discoveries. Despite advances in HIT and increased electronic health record adoption, many challenges to optimal use, interoperability, and data sharing exist. Data standardization across systems is limited, and scanned medical note documents result in unstructured data that make reporting on quality measures for reimbursement burdensome. Different policies and initiatives, including the Health Information Technology for Economic and Clinical Health Act, the Medicare Access and CHIP Reauthorization Act, and the National Cancer Moonshot initiative, among others, all recognize the impact that HIT can have on cancer care...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Delgertsetseg Chuluundorj, Scott A Harding, David Abernethy, Anne Camille La Flamme
Multiple sclerosis (MS) is an immune-mediated disease of the CNS, and monocytes contribute to MS-associated neuroinflammation. While classically-activated monocytes promote inflammation, type II-activated monocytes improve the course of MS. This study investigated type II activation of monocytes and their two main subsets, namely CD14(+) (CD14(++)CD16(-)subset) and CD16(+) monocytes (CD14(+)CD16(+)subset), by glatiramer acetate (GA) or intravenous immunoglobulin (IVIG)-associated immune complexes (IC), both of which are known MS treatments...
October 3, 2016: Immunology and Cell Biology
L Thomaier, M Abernethy, C Paka, Ccg Chen
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Michael J Hochman, Arif H Kamal, Steven P Wolf, Greg P Samsa, David C Currow, Amy P Abernethy, Thomas W LeBlanc
CONTEXT: Anticholinergic drugs can cause several side effects, impairing cognition and quality of life (QOL). Cancer patients are often exposed to increasing cumulative anticholinergic load (ACL) as they approach death, but this burden has not been examined in patients with nonmalignant diseases. OBJECTIVES: To determine ACL and its impact in noncancer versus cancer palliative care patients. METHODS: We performed a secondary analysis of 244 subjects enrolled in a randomized controlled trial...
September 20, 2016: Journal of Pain and Symptom Management
Timothy P Murphy, Christopher J Cooper, Karol M Pencina, Ralph D'Agostino, Joseph Massaro, Donald E Cutlip, Kenneth Jamerson, Alan H Matsumoto, William Henrich, Joseph I Shapiro, Katherine R Tuttle, David J Cohen, Michael Steffes, Qi Gao, D Christopher Metzger, William B Abernethy, Stephen C Textor, John Briguglio, Alan T Hirsch, Sheldon Tobe, Lance D Dworkin
: Randomized clinical trials have not shown an additional clinical benefit of renal artery stent placement over optimal medical therapy alone. However, studies of renal artery stent placement have not examined the relationship of albuminuria and treatment group outcomes. The CORAL study (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) is a prospective clinical trial of 947 participants with atherosclerotic renal artery stenosis randomized to optimal medical therapy with or without renal artery stent which showed no treatment differences (3(5...
November 2016: Hypertension
C J Musante, D R Abernethy, S R Allerheiligen, D A Lauffenburger, M G Zager
Quantitative Systems Pharmacology (QSP) is experiencing increased application in the drug discovery and development process. Like its older sibling, systems biology, the QSP field is comprised of a mix of established disciplines and methods, from molecular biology to engineering to pharmacometrics. As a result, there exist critical segments of the discipline that differ dramatically in approach and a need to bring these groups together toward a common goal.
September 2016: CPT: Pharmacometrics & Systems Pharmacology
Alexander K Smith, David C Currow, Amy P Abernethy, Miriam J Johnson, Yinghui Miao, W John Boscardin, Christine S Ritchie
OBJECTIVES: To determine the prevalence and outcomes of breathlessness in older Americans. SETTING: Community-dwelling older adults. PARTICIPANTS: Individuals aged 70 and older in the nationally representative Health and Retirement Study (2008, follow-up through 2012) (N = 3,671; mean age 78). MEASUREMENTS: Breathlessness was assessed by asking the question, "How often do you become short of breath while awake?" Responses of often or sometimes were considered to represent a level of breathlessness sufficient to warrant clinical attention...
September 7, 2016: Journal of the American Geriatrics Society
Ling Yong, Yibaina Wang, Dajin Yang, Zhaoping Liu, Grant Abernethy, Jianwen Li
Thiocyanate ion is a natural component of cow's milk (hereinafter as milk) which may be artificially augmented to activate the lactoperoxidase milk preservation system. This study presents a survey of thiocyanate levels in raw milk and proposes a naturally occurring baseline concentration of thiocyanate in milk, which is the basis for market supervision. 1669 raw milk samples from China, 270 samples from New Zealand and 120 from the Netherlands were collected in the survey. 65% of the samples contained thiocyanate above the detection limit...
January 15, 2017: Food Chemistry
Kathleen E Bickel, Kristen McNiff, Mary K Buss, Arif Kamal, Dale Lupu, Amy P Abernethy, Michael S Broder, Charles L Shapiro, Anupama Kurup Acheson, Jennifer Malin, Tracey Evans, Monika K Krzyzanowska
PURPOSE: Integrated into routine oncology care, palliative care can improve symptom burden, quality of life, and patient and caregiver satisfaction. However, not all oncology practices have access to specialist palliative medicine. This project endeavored to define what constitutes high-quality primary palliative care as delivered by medical oncology practices. METHODS: An expert steering committee outlined 966 palliative care service items, in nine domains, each describing a candidate element of primary palliative care delivery for patients with advanced cancer or high symptom burden...
September 2016: Journal of Oncology Practice
Michelle DiGiacomo, Yutaka Hatano, Jane Phillips, Joanne Lewis, Amy P Abernethy, David C Currow
BACKGROUND: Globally, most care for people with life-limiting illnesses is provided by informal caregivers. Identifying characteristics of caregivers that may have unmet needs and negative outcomes can help provide better support to facilitate adjustment. AIM: We compared characteristics, expressed unmet needs and outcomes for spousal caregivers, with other caregivers at the end of life, by gender and age. DESIGN: The South Australian Health Omnibus is an annual, random, face-to-face, cross-sectional survey wherein respondents are asked about end-of-life care...
August 8, 2016: Palliative Medicine
Catalina Correa, Juan P Luengas, Scott C Howard, Galo Veintemilla
A 2-year-old boy presented with pneumonia and an abdominal mass was noted incidentally. A right lobe hepatic mass classified as PRETEXT III and congenital absence of the portal vein with drainage of the superior mesenteric vein to the inferior vena cava (Abernethy malformation type I) were confirmed by computed tomography and angiography. After a clinical diagnosis of hepatoblastoma had been made, he was treated with 4 cycles of doxorubicin and cisplatin and hepatic arterial chemoembolization with doxorubicin, after which the tumor was classified as POSTEXT III...
July 27, 2016: Journal of Pediatric Hematology/oncology
Brendon D Gill, Grant A Abernethy, Rebecca J Green, Harvey E Indyk
A method for the determination of vitamin D2 and vitamin D3 in fortified milk powders and infant and adult nutritional formulas is described. Samples are saponified at high temperature and lipid-soluble components are extracted into isooctane. A portion of the isooctane layer is transferred and washed, and an aliquot of 4-phenyl-1,2,4-triazoline-3,5-dione is added to derivatize the vitamin D to form a high-molecular-mass, easily ionizable adduct. The vitamin D adduct is then re-extracted into a small volume of acetonitrile and analyzed by RPLC...
September 2016: Journal of AOAC International
Purwa Joshi, John Fink, Peter Alan Barber, Alan Davis, Jeremy Lanford, Andrea Seymour, Peter Wright, Wendy Busby, Ginny Abernethy, Annemarei Anna Ranta
The New Zealand National Stroke Network introduced a National Stroke Thrombolysis Register on the first of January 2015 to assist with quality assurance and continuous service improvement. In the first 6 months, there were 179 [75 women, mean (SD) age 69.9 (14) years] treated with stroke thrombolysis out of a total of 2,796 ischaemic stroke patients, giving a national thrombolysis rate of 6.4%. The median [Inter-quartile range (IQR)] onset-to-treatment time was 154 (125-190) minutes, and the median (IQR) door-to-needle time was 74...
2016: New Zealand Medical Journal
G V Long, V Atkinson, P A Ascierto, C Robert, J C Hassel, P Rutkowski, K J Savage, F Taylor, C Coon, I Gilloteau, H B Dastani, I M Waxman, A P Abernethy
BACKGROUND: Nivolumab has shown significant survival benefit and a favorable safety profile compared with dacarbazine chemotherapy among treatment-naïve patients with metastatic melanoma in the CheckMate 066 phase III study. Results from the health-related quality of life (HRQoL) analyses from CheckMate 066 are presented. PATIENTS AND METHODS: HRQoL was evaluated at baseline and every 6 weeks while on treatment using the European Organisation for Research and Treatment of Care (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and the EuroQoL Five Dimensions Questionnaire (EQ-5D)...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Jonathan R Mosedale, Kirsten E Abernethy, Richard Smart, Robert J Wilson, Ilya M D Maclean
The cultivation of grapevines for winemaking, known as viticulture, is widely cited as a climate-sensitive agricultural system that has been used as an indicator of both historic and contemporary climate change. Numerous studies have questioned the viability of major viticulture regions under future climate projections. We review the methods used to study the impacts of climate change on viticulture in the light of what is known about the effects of climate and weather on the yields and quality of vineyard harvests...
July 2, 2016: Global Change Biology
Kathy Abernethy
No abstract text is available yet for this article.
June 2016: Post Reproductive Health
Wendy Smyth, Gail Abernethy
This article reports the success, or otherwise, of strategies implemented to sustain nursing grand rounds in a large regional health service in North Queensland, Australia. Nursing grand rounds had been introduced in late 2010 to increase nurses' engagement with research and evidence-based practice. Although the format, topics, and purpose of grand rounds have changed, attendees continue to positively evaluate each presentation. However, after 5 years, the initiative has expanded and somewhat modified its focus...
July 1, 2016: Journal of Continuing Education in Nursing
Arif H Kamal, Janet Bull, Dio Kavalieratos, Jonathan M Nicolla, Laura Roe, Martha Adams, Amy P Abernethy
BACKGROUND: Assessing and reporting the quality of care provided are increasingly important in palliative care, but we currently lack practical, efficient approaches for collection and reporting. OBJECTIVE: In response, the Global Palliative Care Quality Alliance ("Alliance") sought to create a Quality Data Collection Tool for Palliative Care (QDACT-PC). METHODS: We collaboratively and iteratively developed QDACT-PC, an electronic, point-of-care quality monitoring system for palliative care that supports prospective quality assessment and reporting in any clinical setting...
June 27, 2016: Journal of Palliative Medicine
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