Xuyang Zhang, Huanhuan Li, Haomiao Wang, Qian Zhang, Xueyun Deng, Shuixian Zhang, Long Wang, Chao Guo, Fengchun Zhao, Yi Yin, Tengyuan Zhou, Jun Zhong, Hui Feng, Wei Chen, Jun Zhang, Hua Feng, Rong Hu
Hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), has been implicated in the development of persistent cognitive impairment, significantly compromising the quality of life for affected individuals. Nevertheless, the precise underlying mechanism remains elusive. Here, we report for the first time that the accumulation of iron within the hippocampus, distal to the site of ICH in the striatum, is causally linked to the observed cognitive impairment with both clinical patient data and animal model...
February 13, 2024: Redox Biology