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kenneth kendler

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https://www.readbyqxmd.com/read/28319814/time-specific-and-cumulative-effects-of-exposure-to-parental-externalizing-behavior-on-risk-for-young-adult-alcohol-use-disorder
#1
Alexis C Edwards, Sara L Lönn, Katherine J Karriker-Jaffe, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
BACKGROUND: Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. METHODS: We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries...
March 8, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28317498/school-achievement-iq-and-risk-of-alcohol-use-disorder-a-prospective-co-relative-analysis-in-a-swedish-national-cohort
#2
Kenneth S Kendler, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
OBJECTIVE: Most studies suggest that poor cognitive functioning in adolescence increases risk of alcohol use disorders (AUDs). We seek to clarify the causes of this association. METHOD: In Swedish individuals born from 1972 to 1990 in whom cognitive functioning was assessed by school achievement at age 16 years (males and females, N = 1,796,048) and by IQ at ages 18-20 (males, N = 554,644), we examined the hazard ratio (HR) for AUD ascertained from public registries...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28303776/familial-and-special-twin-influences-on-cigarette-use-initiation
#3
Cristina B Bares, Hermine H Maes, Kenneth S Kendler
BACKGROUND: Shared experiences within families play an important role in the initiation of cigarette use among adolescents. Behavioral genetic studies using various samples have implicated that the shared environment that twins experience is an important source of influence on whether adolescents initiate cigarette use. Whether the special twin environment, in addition to the shared environment, contributes significantly to making twin siblings more similar in cigarette initiation, and whether the influence of the special twin environment persists into adulthood, is less clear...
April 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28229455/maternal-perinatal-and-concurrent-depressive-symptoms-and-child-behavior-problems-a-sibling-comparison-study
#4
Line C Gjerde, Espen Moen Eilertsen, Ted Reichborn-Kjennerud, Tom A McAdams, Henrik Daae Zachrisson, Imac Maria Zambrana, Espen Røysamb, Kenneth S Kendler, Eivind Ystrom
BACKGROUND: Previous studies have found significant associations between maternal prenatal and postpartum depression and child behavior problems (CBP). The present study investigates whether associations remain in a prospective, longitudinal design adjusted for familial confounding. METHODS: The sample comprised 11,599 families including 17,830 siblings from the Norwegian Mother and Child Cohort study. Mothers reported depressive symptoms at gestational weeks 17 and 30, as well as 6 months, 1...
February 23, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28226201/genomewide-association-study-of-alcohol-dependence-identifies-risk-loci-altering-ethanol-response-behaviors-in-model-organisms
#5
Amy E Adkins, Laura M Hack, Tim B Bigdeli, Vernell S Williamson, G Omari McMichael, Mohammed Mamdani, Alexis Edwards, Fazil Aliev, Robin F Chan, Poonam Bhandari, Richard C Raabe, Joseph T Alaimo, GinaMari G Blackwell, Arden A Moscati, Ryan S Poland, Benjamin Rood, Diana G Patterson, Dermot Walsh, John B Whitfield, Gu Zhu, Grant W Montgomery, Anjali K Henders, Nicholas G Martin, Andrew C Heath, Pamela A F Madden, Josef Frank, Monika Ridinger, Norbert Wodarz, Michael Soyka, Peter Zill, Marcus Ising, Markus M Nöthen, Falk Kiefer, Marcella Rietschel, Joel Gelernter, Richard Sherva, Ryan Koesterer, Laura Almasy, Hongyu Zhao, Henry R Kranzler, Lindsay A Farrer, Brion S Maher, Carol A Prescott, Danielle M Dick, Silviu A Bacanu, Laura D Mathies, Andrew G Davies, Vladimir I Vladimirov, Mike Grotewiel, M Scott Bowers, Jill C Bettinger, Bradley T Webb, Michael F Miles, Kenneth S Kendler, Brien P Riley
BACKGROUND: Alcohol Dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified. METHODS: We conducted a genomewide association study in 706 related AD cases and 1748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms to assess the role of orthologous genes in ethanol response behaviors. We tested one primate-specific gene for expression differences in case/control post-mortem brain tissue...
February 22, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28195579/11-670-whole-genome-sequences-representative-of-the-han-chinese-population-from-the-converge-project
#6
Na Cai, Tim B Bigdeli, Warren W Kretzschmar, Yihan Li, Jieqin Liang, Jingchu Hu, Roseann E Peterson, Silviu Bacanu, Bradley Todd Webb, Brien Riley, Qibin Li, Jonathan Marchini, Richard Mott, Kenneth S Kendler, Jonathan Flint
The China, Oxford and Virginia Commonwealth University Experimental Research on Genetic Epidemiology (CONVERGE) project on Major Depressive Disorder (MDD) sequenced 11,670 female Han Chinese at low-coverage (1.7X), providing the first large-scale whole genome sequencing resource representative of the largest ethnic group in the world. Samples are collected from 58 hospitals from 23 provinces around China. We are able to call 22 million high quality single nucleotide polymorphisms (SNP) from the nuclear genome, representing the largest SNP call set from an East Asian population to date...
February 14, 2017: Scientific Data
https://www.readbyqxmd.com/read/28152564/age-of-onset-and-family-history-as-indicators-of-polygenic-risk-for-major-depression
#7
Anna R Docherty, Alexis C Edwards, Fuzhong Yang, Roseann E Peterson, Chelsea Sawyers, Daniel E Adkins, Ashlee A Moore, Bradley T Webb, Silviu A Bacanu, Jonathan Flint, Kenneth S Kendler
BACKGROUND: The extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies. METHODS: This research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9,854; MD case, n = 4,927)...
February 2, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28121394/symptoms-of-major-depression-their-stability-familiality-and-prediction-by-genetic-temperamental-and-childhood-environmental-risk-factors
#8
Kenneth S Kendler, Steven H Aggen
BACKGROUND: Psychiatry has long sought to develop biological diagnostic subtypes based on symptomatic differences. This effort assumes that symptoms reflect, with good fidelity, underlying etiological processes. We address this question for major depression (MD). METHODS: We examine, in twins from a population-based registry, similarity in symptom endorsement in individuals meeting criteria for last-year MD at separate interview waves and in concordant twin pairs...
January 25, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28117924/environmental-influences-on-alcohol-use-informing-research-on-the-joint-effects-of-genes-and-the-environment-in-diverse-u-s-populations
#9
Karen G Chartier, Katherine J Karriker-Jaffe, Cory R Cummings, Kenneth S Kendler
BACKGROUND AND OBJECTIVES: This review aimed to inform the current state of alcohol research on the joint effects of genes and the environment conducted in U.S. racial/ethnic minority populations, focusing on African Americans, Latinos/Hispanics, Asians, and American Indians. METHODS: A key-word and author-based search was conducted and supplemented with direct contact to researchers in this area to ensure a comprehensive inclusion of published, peer-reviewed studies...
January 24, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28108863/genetic-and-environmental-structure-of-dsm-iv-criteria-for-antisocial-personality-disorder-a-twin-study
#10
Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A Gillespie, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Ted Reichborn-Kjennerud
Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level...
January 21, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28103713/divorce-and-the-onset-of-alcohol-use-disorder-a-swedish-population-based-longitudinal-cohort-and-co-relative-study
#11
Kenneth S Kendler, Sara Larsson Lönn, Jessica Salvatore, Jan Sundquist, Kristina Sundquist
OBJECTIVE: The purpose of this study was to clarify the magnitude and nature of the relationship between divorce and risk for alcohol use disorder (AUD). METHOD: In a population-based Swedish sample of married individuals (N=942,366), the authors examined the association between divorce or widowhood and risk for first registration for AUD. AUD was assessed using medical, criminal, and pharmacy registries. RESULTS: Divorce was strongly associated with risk for first AUD onset in both men (hazard ratio=5...
January 20, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28092418/an-examination-of-the-etiologic-overlap-between-the-genetic-and-environmental-influences-on-insomnia-and-common-psychopathology
#12
Mackenzie J Lind, Sage E Hawn, Christina M Sheerin, Steven H Aggen, Robert M Kirkpatrick, Kenneth S Kendler, Ananda B Amstadter
BACKGROUND: Insomnia is comorbid with internalizing and externalizing psychiatric disorders. However, the extent to which the etiologic influences on insomnia and common psychopathology overlap is unclear. There are limited genetically informed studies of insomnia and internalizing disorders and few studies of overlap exist with externalizing disorders. METHODS: We utilized twin data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders (total n = 7,500)...
January 16, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28038364/electronic-cigarette-use-and-uptake-of-cigarette-smoking-a-longitudinal-examination-of-u-s-college-students
#13
Tory R Spindle, Marzena M Hiler, Megan E Cooke, Thomas Eissenberg, Kenneth S Kendler, Danielle M Dick
INTRODUCTION: Electronic cigarette (e-cigarette) use prevalence is increasing among U.S. adolescents and adults but recent longitudinal data for college/university students are scarce. Furthermore, the extent that e-cigarette use is associated with the onset of cigarette smoking and the factors that lead to the uptake of e-cigarettes in college students has not been explored. METHODS: 3757 participants from a Mid-Atlantic university (women: 66%; White: 45%; Black: 21%; Asian: 19%; Hispanic/Latino: 6%) were surveyed in 2014 and again in 2015...
April 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28003468/the-clinical-features-of-paranoia-in-the-20th-century-and-their-representation-in-diagnostic-criteria-from-dsm-iii-through-dsm-5
#14
Kenneth S Kendler
This review traces, through psychiatric textbooks, the history of the Kraepelinian concept of paranoia in the 20th century and then relates the common reported symptoms and signs to the diagnostic criteria for paranoia/delusional disorder in DSM-III through DSM-5. Clinical descriptions of paranoia appearing in 10 textbooks, published 1899 to 1970, revealed 11 prominent symptoms and signs reported by 5 or more authors. Three symptoms (systematized delusions, minimal hallucinations, and prominent ideas of reference) and 2 signs (chronic course and minimal affective deterioration) were reported by 8 or 9 of the authors...
December 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28002544/the-genetic-architecture-of-major-depressive-disorder-in-han-chinese-women
#15
Roseann E Peterson, Na Cai, Tim B Bigdeli, Yihan Li, Mark Reimers, Anna Nikulova, Bradley T Webb, Silviu-Alin Bacanu, Brien P Riley, Jonathan Flint, Kenneth S Kendler
Importance: Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution of classes of genetic variation across the genome to inform future genetic studies of MDD. Objectives: To apply aggregate genetic risk methods to clarify the genetic architecture of MDD by estimating and partitioning heritability by chromosome, minor allele frequency, and functional annotations and to test for enrichment of rare deleterious variants...
February 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/27981669/alcohol-use-disorder-and-divorce-evidence-for-a-genetic-correlation-in-a-population-based-swedish-sample
#16
Jessica E Salvatore, Sara Larsson Lönn, Jan Sundquist, Paul Lichtenstein, Kristina Sundquist, Kenneth S Kendler
AIMS: We tested the association between alcohol use disorder (AUD) and divorce; estimated the genetic and environmental influences on divorce; estimated how much genetic and environmental influences accounted for covariance between AUD and divorce; and estimated latent genetic and environmental correlations between AUD and divorce. We tested sex differences in these effects. DESIGN: We identified twin and sibling pairs with AUD and divorce information in Swedish national registers...
April 2017: Addiction
https://www.readbyqxmd.com/read/27940325/predictors-and-mental-health-outcomes-of-potentially-traumatic-event-exposure
#17
Cassie Overstreet, Erin C Berenz, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
The aims were two-fold: to examine prevalence and correlates of lifetime potentially traumatic event (PTE) exposure and to explore the relationships between PTE exposure and mental health outcomes (i.e., trauma related distress, alcohol use quantity and frequency, depression symptoms, and anxiety symptoms) within a large sample of college freshmen. 6120 participants, consisting of three cohorts of incoming freshman at a large southeastern university, completed an online assessment battery measuring a multitude of factors including PTEs, personality, relationships (i...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27930698/major-depression-as-a-complex-dynamic-system
#18
Angélique O J Cramer, Claudia D van Borkulo, Erik J Giltay, Han L J van der Maas, Kenneth S Kendler, Marten Scheffer, Denny Borsboom
In this paper, we characterize major depression (MD) as a complex dynamic system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired...
2016: PloS One
https://www.readbyqxmd.com/read/27918840/resilience-and-risk-for-alcohol-use-disorders-a-swedish-twin-study
#19
Elizabeth C Long, Sara L Lönn, Jianguang Ji, Paul Lichtenstein, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler
BACKGROUND: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. METHODS: Resilience was assessed on a 9-point scale during a personal interview in 1,653,721 Swedish men aged 17 to 25 years...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27892595/the-rate-of-change-in-alcohol-misuse-across-adolescence-is-heritable
#20
Alexis C Edwards, Jon Heron, Vladimir Vladimirov, Aaron R Wolen, Daniel E Adkins, Fazil Aliev, Matthew Hickman, Kenneth S Kendler
BACKGROUND: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for the establishment of alcohol use and misuse patterns, which can have psychosocial and medical consequences. Although changes in alcohol use during this time have been phenotypically characterized, their genetic nature is poorly understood. METHODS: Participants of the Avon Longitudinal Study of Parents and Children completed the Alcohol Use Disorders Identification Test (AUDIT) 4 times from age 16 to 20...
January 2017: Alcoholism, Clinical and Experimental Research
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