keyword
MENU ▼
Read by QxMD icon Read
search

kenneth kendler

keyword
https://www.readbyqxmd.com/read/29885144/childhood-risk-factors-for-heavy-episodic-alcohol-use-and-alcohol-problems-in-late-adolescence-a-marginal-structural-model-analysis
#1
Kenneth S Kendler, Charles O Gardner, Alexis C Edwards, Danielle M Dick, Matt Hickman, John Macleod, Jon Heron
OBJECTIVE: This study seeks to clarify the nature of the association between five well-studied late childhood predictors and alcohol-related behaviors in adolescence. METHOD: We examined, in 7,168 subjects from the Avon Longitudinal Study of Parents and Children (ALSPAC), using linear probability and marginal structural models, the association between parental alcohol problems, peer group deviance, antisocial behavior, and low parental monitoring, and sensation seeking assessed at multiple times from ages 12...
May 2018: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/29861519/associations-between-personality-and-distress-tolerance-among-trauma-exposed-young-adults
#2
Nadia Chowdhury, Salpi Kevorkian, Sage E Hawn, Ananda B Amstadter, Danielle Dick, Kenneth S Kendler, Erin C Berenz
Low distress tolerance (DT) is related to negative mental health outcomes, particularly among trauma-exposed populations, who are at greater risk for mental health problems. However, little is known about potential etiological factors underlying the development of perceived (i.e., self-report) or behaviorally assessed DT. The present study examined associations between Big Five personality factors (i.e., openness, conscientiousness, extraversion, agreeableness, & neuroticism) and multiple measures of DT...
January 1, 2018: Personality and Individual Differences
https://www.readbyqxmd.com/read/29843549/associations-between-initial-subjective-experiences-with-tobacco-and-self-reported-recent-use-in-young-adulthood
#3
Elizabeth K Do, Elizabeth C Prom-Wormley, Bernard F Fuemmeler, Danielle M Dick, Kenneth S Kendler, Hermine H Maes
BACKGROUND: Youth tobacco use behaviors are predictive of patterns in adulthood and effect long-term health outcomes. Yet, few studies have examined the effect of initial subjective experiences (ISEs) during first tobacco use, which has been found to be an indicator of individuals. sensitivity to nicotine and vulnerability to dependence. OBJECTIVE: The present study aimed to determine the prevalence of ISEs across a variety of tobacco products, evaluate the factor structure of ISEs by first tobacco product used, and examine the relationship between ISEs and recent (30-day) use of tobacco products across time, using a university sample...
May 29, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29806869/the-effect-of-parental-drinking-on-alcohol-use-in-young-adults-the-mediating-role-of-parental-monitoring-and-peer-deviance
#4
Liam Mahedy, Georgina J MacArthur, Gemma Hammerton, Alexis C Edwards, Kenneth S Kendler, John Macleod, Matthew Hickman, Simon C Moore, Jon Heron
BACKGROUND/AIMS: Evidence demonstrating an association between parental alcohol use and offspring alcohol use from robust prospective studies is lacking. We tested the direct and indirect associations between parental and young adult alcohol use via early alcohol initiation, parental monitoring and associating with deviant peers. DESIGN: Prospective birth cohort study. Path analysis was used to assess the possible association between parental alcohol use (assessed at 12 years) and alcohol use in young adults (assessed at 18 years) via potential mediators (assessed at 14 and 15...
May 28, 2018: Addiction
https://www.readbyqxmd.com/read/29779187/dualism-and-its-place-in-a-philosophical-structure-for-psychiatry
#5
Hane Htut Maung
It is often claimed in parts of the psychiatric literature that neuroscientific research into the biological basis of mental disorder undermines dualism in the philosophy of mind. This paper shows that such a claim does not apply to all forms of dualism. Focusing on Kenneth Kendler's discussion of the mind-body problem in biological psychiatry, I argue that such criticism of dualism often conflates the psychological and phenomenal concepts of the mental. Moreover, it fails to acknowledge that there are different varieties of dualism, and so overlooks the important metaphysical insights of contemporary dualist philosophers...
May 19, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29761553/method-to-estimate-the-approximate-samples-size-that-yield-a-certain-number-of-significant-gwas-signals-in-polygenic-traits
#6
Silviu-Alin Bacanu, Kenneth S Kendler
To argue for increased sample collection for disorders without significant findings, researchers resorted to plotting, for multiple traits, the number of significant findings as a function of the sample size. However, for polygenic traits, the prevalence of the disorder confounds the relationship between the number of significant findings and the sample size. To adjust the number of significant findings for prevalence, we develop a method that uses the expected noncentrality of the contrast between liabilities of cases and controls...
May 14, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29757125/cross-cultural-comparison-of-genetic-and-cultural-transmission-of-smoking-initiation-using-an-extended-twin-kinship-model
#7
Hermine H Maes, Kate Morley, Michael C Neale, Kenneth S Kendler, Andrew C Heath, Lindon J Eaves, Nicholas G Martin
BACKGROUND: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic and environmental influences, they do not provide information on the processes of assortative mating and parent-offspring transmission and their contribution to the variability explained by genetic and/or environmental factors. METHODS: We examined the role of genetic and environmental factors in individual differences for smoking initiation (SI) using an extended kinship design...
May 14, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29700475/genome-wide-association-analyses-identify-44-risk-variants-and-refine-the-genetic-architecture-of-major-depression
#8
Naomi R Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M Byrne, Abdel Abdellaoui, Mark J Adams, Esben Agerbo, Tracy M Air, Till M F Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan F T Beekman, Tim B Bigdeli, Elisabeth B Binder, Douglas R H Blackwood, Julien Bryois, Henriette N Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Hvarregaard Christensen, Toni-Kim Clarke, Jonathan I R Coleman, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E Crawford, Cheynna A Crowley, Hassan S Dashti, Gail Davies, Ian J Deary, Franziska Degenhardt, Eske M Derks, Nese Direk, Conor V Dolan, Erin C Dunn, Thalia C Eley, Nicholas Eriksson, Valentina Escott-Price, Farnush Hassan Farhadi Kiadeh, Hilary K Finucane, Andreas J Forstner, Josef Frank, Héléna A Gaspar, Michael Gill, Paola Giusti-Rodríguez, Fernando S Goes, Scott D Gordon, Jakob Grove, Lynsey S Hall, Eilis Hannon, Christine Søholm Hansen, Thomas F Hansen, Stefan Herms, Ian B Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M Hougaard, Ming Hu, Craig L Hyde, Marcus Ising, Rick Jansen, Fulai Jin, Eric Jorgenson, James A Knowles, Isaac S Kohane, Julia Kraft, Warren W Kretzschmar, Jesper Krogh, Zoltán Kutalik, Jacqueline M Lane, Yihan Li, Yun Li, Penelope A Lind, Xiaoxiao Liu, Leina Lu, Donald J MacIntyre, Dean F MacKinnon, Robert M Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Peter McGuffin, Sarah E Medland, Divya Mehta, Christel M Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Jonathan Mill, Francis M Mondimore, Grant W Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G Nivard, Dale R Nyholt, Paul F O'Reilly, Hogni Oskarsson, Michael J Owen, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Erik Pettersson, Wouter J Peyrot, Giorgio Pistis, Danielle Posthuma, Shaun M Purcell, Jorge A Quiroz, Per Qvist, John P Rice, Brien P Riley, Margarita Rivera, Saira Saeed Mirza, Richa Saxena, Robert Schoevers, Eva C Schulte, Ling Shen, Jianxin Shi, Stanley I Shyn, Engilbert Sigurdsson, Grant B C Sinnamon, Johannes H Smit, Daniel J Smith, Hreinn Stefansson, Stacy Steinberg, Craig A Stockmeier, Fabian Streit, Jana Strohmaier, Katherine E Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A Thomson, Thorgeir E Thorgeirsson, Chao Tian, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Alexander Viktorin, Peter M Visscher, Yunpeng Wang, Bradley T Webb, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H Witt, Yang Wu, Hualin S Xi, Jian Yang, Futao Zhang, Volker Arolt, Bernhard T Baune, Klaus Berger, Dorret I Boomsma, Sven Cichon, Udo Dannlowski, E C J de Geus, J Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tõnu Esko, Hans J Grabe, Steven P Hamilton, Caroline Hayward, Andrew C Heath, David A Hinds, Kenneth S Kendler, Stefan Kloiber, Glyn Lewis, Qingqin S Li, Susanne Lucae, Pamela F A Madden, Patrik K Magnusson, Nicholas G Martin, Andrew M McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Merete Nordentoft, Markus M Nöthen, Michael C O'Donovan, Sara A Paciga, Nancy L Pedersen, Brenda W J H Penninx, Roy H Perlis, David J Porteous, James B Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas G Schulze, Jordan W Smoller, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna M Weissman, Thomas Werge, Ashley R Winslow, Cathryn M Lewis, Douglas F Levinson, Gerome Breen, Anders D Børglum, Patrick F Sullivan
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal...
April 26, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29667198/alcohol-availability-and-onset-and-recurrence-of-alcohol-use-disorder-examination-in-a-longitudinal-cohort-with-cosibling-analysis
#9
Katherine J Karriker-Jaffe, Henrik Ohlsson, Kenneth S Kendler, Won Kim Cook, Kristina Sundquist
BACKGROUND: Recent reviews of associations of alcohol availability with alcohol outcomes suggest findings are highly inconsistent and highlight a lack of longitudinal and causal evidence. Effect modification (moderation or statistical interaction), which could contribute to the inconsistent picture in the existing literature, has not been systematically assessed. We examined associations of alcohol availability with onset and recurrence of alcohol use disorder (AUD) using multilevel, longitudinal population data from Sweden and tested hypothesized effect modifiers to identify groups for whom increased alcohol availability may be particularly risky...
June 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29652647/prevalence-and-predictors-of-ptsd-among-a-college-sample
#10
Shannon E C Usack, Terrell A Hicks, Jessica Bourdon, Christina M Sheerin, Cassie M Overstreet, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: This study examined the prevalence and correlates of probable posttraumatic stress disorder (PTSD) in freshman entering college and prospective associations of probable PTSD with additional outcomes. PARTICIPANTS: 2,310 students with data collected from Fall 2014 through Spring 2015. METHODS: Incoming freshman completed a survey assessing for relevant variables at the beginning of fall semester and during the spring semester. RESULTS: Seventy percent of the sample endorsed experiencing at least one potentially traumatic event (PTE)...
April 13, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29558815/a-twin-study-of-normative-personality-and-dsm-iv-personality-disorder-criterion-counts-evidence-for-separate-genetic-influences
#11
Nikolai Czajkowski, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Michael C Neale, Gun Peggy Knudsen, Nathan A Gillespie, Espen Røysamb, Kristian Tambs, Ted Reichborn-Kjennerud
OBJECTIVE: Both normative personality and DSM-IV personality disorders have been found to be heritable. However, there is limited knowledge about the extent to which the genetic and environmental influences underlying DSM personality disorders are shared with those of normative personality. The aims of this study were to assess the phenotypic similarity between normative and pathological personality and to investigate the extent to which genetic and environmental influences underlying individual differences in normative personality account for symptom variance across DSM-IV personality disorders...
March 21, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29554991/historical-precedents-for-the-dsm-iii-bereavement-exclusion-criteria-for-major-depression
#12
Kenneth S Kendler
BACKGROUND: I review the historical antecedents of the two key features of the bereavement exclusion (BE) for major depression (MD) criteria initially proposed in DSM-III: (i) a context-dependent approach to the evaluation of MD which required that the diagnosis be given only when course, symptoms and signs are 'out of proportion' to experienced adversities, and (ii) bereavement is the sole adversity for which this context-dependent approach should be utilized. METHODS: A review of 49 textbook and review articles on depression or melancholia published 1880-1960...
March 20, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29540840/correction-to-psychiatric-genetics-and-the-structure-of-psychopathology
#13
Jordan W Smoller, Ole A Andreassen, Howard J Edenberg, Stephen V Faraone, Stephen J Glatt, Kenneth S Kendler
In the Table 1 legend, the reference numbers and symbols were not correctly presented in the footnotes. The corrected footnotes are presented below.
March 14, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29530109/the-nature-of-nurture-using-a-virtual-parent-design-to-test-parenting-effects-on-children-s-educational-attainment-in-genotyped-families
#14
Timothy C Bates, Brion S Maher, Sarah E Medland, Kerrie McAloney, Margaret J Wright, Narelle K Hansell, Kenneth S Kendler, Nicholas G Martin, Nathan A Gillespie
Research on environmental and genetic pathways to complex traits such as educational attainment (EA) is confounded by uncertainty over whether correlations reflect effects of transmitted parental genes, causal family environments, or some, possibly interactive, mixture of both. Thus, an aggregate of thousands of alleles associated with EA (a polygenic risk score; PRS) may tap parental behaviors and home environments promoting EA in the offspring. New methods for unpicking and determining these causal pathways are required...
April 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29505386/relationships-among-avoidant-personality-disorder-social-anxiety-disorder-and-normative-personality-traits-a-twin-study
#15
Audun Welander-Vatn, Fartein Ask Torvik, Nikolai Czajkowski, Kenneth S Kendler, Ted Reichborn-Kjennerud, Gun Peggy Knudsen, Eivind Ystrom
Avoidant personality disorder (AvPD) and social anxiety disorder (SAD) share risk factors to a substantial degree, and both are characterized by the experience of anxiety in social situations. The authors investigated whether these disorders are differentially related to the Big Five personality traits. They also examined the underlying genetic and environmental influences on these associations. A population-based sample of 1,761 female twins was interviewed at baseline, and 1,471 of these were re-interviewed 10 years later...
March 5, 2018: Journal of Personality Disorders
https://www.readbyqxmd.com/read/29495898/molecular-genetic-analysis-subdivided-by-adversity-exposure-suggests-etiologic-heterogeneity-in-major-depression
#16
Roseann E Peterson, Na Cai, Andy W Dahl, Tim B Bigdeli, Alexis C Edwards, Bradley T Webb, Silviu-Alin Bacanu, Noah Zaitlen, Jonathan Flint, Kenneth S Kendler
OBJECTIVE: The extent to which major depression is the outcome of a single biological mechanism or represents a final common pathway of multiple disease processes remains uncertain. Genetic approaches can potentially identify etiologic heterogeneity in major depression by classifying patients on the basis of their experience of major adverse events. METHOD: Data are from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology (CONVERGE) project, a study of Han Chinese women with recurrent major depression aimed at identifying genetic risk factors for major depression in a rigorously ascertained cohort carefully assessed for key environmental risk factors (N=9,599)...
March 2, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29417130/the-origin-of-spousal-resemblance-for-alcohol-use-disorder
#17
Kenneth S Kendler, Sara Larsson Lönn, Jessica Salvatore, Jan Sundquist, Kristina Sundquist
Importance: Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. Objectives: To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner and to explore changes in the risk for AUD registration in individuals with multiple marriages as they transition from a spouse with AUD to one without or vice versa...
March 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29405876/effects-of-social-support-on-the-association-between-precollege-sexual-assault-and-college-onset-victimization
#18
Sage E Hawn, Mackenzie J Lind, Abigail Conley, Cassie M Overstreet, Kenneth S Kendler, Danielle M Dick, Ananda B Amstadter
OBJECTIVE: This study examined the moderating and mediating effects of perceived social support on the association between precollege sexual assault (SA) and college-onset SA. PARTICIPANTS: A representative sample of 6,132 undergraduates. METHODS: The PLUM procedure in SPSS was used to test the moderation model, with individual regressions conducted in a hierarchical fashion. A weighted least squared mean and variance adjusted (WLSMV) mediation model was used to examine the mediating effect of social support...
February 6, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29405378/polygenic-risk-score-prediction-of-alcohol-dependence-symptoms-across-population-based-and-clinically-ascertained-samples
#19
Jeanne E Savage, Jessica E Salvatore, Fazil Aliev, Alexis C Edwards, Matthew Hickman, Kenneth S Kendler, John Macleod, Antti Latvala, Anu Loukola, Jaakko Kaprio, Richard J Rose, Grace Chan, Victor Hesselbrock, Bradley T Webb, Amy Adkins, Tim B Bigdeli, Brien P Riley, Danielle M Dick
BACKGROUND: Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations. The aim of this study was thus to evaluate whether aggregate genetic risk for AUDs differed between clinically ascertained and population-based epidemiological samples. METHODS: Four independent samples were obtained: 2 from unselected birth cohorts (Avon Longitudinal Study of Parents and Children [ALSPAC], N = 4,304; FinnTwin12 [FT12], N = 1,135) and 2 from families densely affected with AUDs, identified from treatment-seeking patients (Collaborative Study on the Genetics of Alcoholism, N = 2,097; Irish Affected Sib Pair Study of Alcohol Dependence, N = 706)...
March 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29369040/testing-genetic-and-environmental-associations-between-personality-disorders-and-cocaine-use-a-population-based-twin-study
#20
Nathan A Gillespie, Steven H Aggen, Amanda E Gentry, Michael C Neale, Gun P Knudsen, Robert F Krueger, Susan C South, Nikolai Czajkowski, Ragnar Nesvåg, Eivind Ystrom, Tom H Rosenström, Fartein A Torvik, Ted Reichborn-Kjennerud, Kenneth S Kendler
Until now, data have not been available to elucidate the genetic and environmental sources of comorbidity between all 10 DSM-IV personality disorders (PDs) and cocaine use. Our aim was to determine which PD traits are linked phenotypically and genetically to cocaine use. Cross-sectional data were obtained in a face-to-face interview between 1999 and 2004. Subjects were 1,419 twins (µage = 28.2 years, range = 19-36) from the Norwegian Institute of Public Health Twin Panel, with complete lifetime cocaine use and criteria for all 10 DSM-IV PDs...
February 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
keyword
keyword
40449
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"