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https://www.readbyqxmd.com/read/26665193/-potential-role-of-patient-derived-tumor-xenografts-pdtxs-in-the-selection-of-optimal-therapeutic-strategy
#1
József Tóvári
The rapid selection of the efficient anticancer therapy may decrease the unwanted burden to patients and has financial consequences. Tumor models including xenografts in mice were used previously mostly in the development of new anticancer drugs. Nowadays xenografts from direct patient-derived tumor tissues (PDTT) in immune deficient mice yield better models than experimental tumors originating from cell cultures. The new method enables researchers to observe heterogeneous tumor cells with their surrounding tissue elements and matrices representing the clinical situation in humans much better...
December 2015: Magyar Onkologia
https://www.readbyqxmd.com/read/24719933/antitumor-effect-of-fp3-on-a-patient-derived-tumor-tissue-xenograft-model-of-rectal-carcinoma
#2
COMPARATIVE STUDY
Tienan Bi, Tienan Bi, Huanrong Lan, Xinxia Hu, Min Zhu, Zhenzhen Xu, Jinxi Hu, Lisong Teng, Ketao Jin
BACKGROUND/AIMS: FP3 is an engineered protein which contains the extracellular domain 2 of VEGF receptor 1 (Flt-1) and extracellular domain 3 and 4 of VEGF receptor 2 (Flk-1, KDR) fused to the Fc portion of human immunoglobulin G1. Previous studies demonstrated its antiangiogenic and antitumor effects in vitro and in vivo. METHODOLOGY: In this study, a PDTT xenograft model of rectal carcinoma was established for assessment of the antitumor activity of FP3. Xenografts were treated with FP3 or bevacizumab (Avastin)...
November 2013: Hepato-gastroenterology
https://www.readbyqxmd.com/read/24719929/heterogeneity-related-anticancer-therapy-response-differences-in-metastatic-colon-carcinoma-new-hints-to-tumor-site-based-personalized-cancer-therapy
#3
COMPARATIVE STUDY
Weihuo Pan, Shuru Huang, Jianwei Zhang, Bo Zhao, Haohao Wang, Fanlong Liu, Ketao Jin, Xiaozhou Mou
BACKGROUND/AIMS: Heterogeneity in primary tumor and related metastases may result in different response to anticancer therapy. Previous work revealed that there were heterogeneity in primary colon carcinoma and matched lymphatic and hepatic metastases. Whether such heterogeneity in primary colon carcinoma and corresponding lymphatic and hepatic metastases would result in different response to anticancer therapy is unknown. METHODOLOGY: To investigate whether the heterogeneity in primary colon carcinoma and matched lymphatic and hepatic metastases would result in different response to anticancer therapy, patient-derived tumor tissue (PDTT) xenograft models of colon carcinoma with lymphatic and hepatic metastases were used to evaluate the response to VEGF-targeted therapy (bevacizumab) in combination with chemotherapy (capecitabine)...
November 2013: Hepato-gastroenterology
https://www.readbyqxmd.com/read/24025274/heterogeneity-related-anticancer-therapy-response-differences-in-metastatic-colon-carcinoma-new-hints-to-tumor-site-based-personalized-cancer-therapy
#4
Shuru Huang, Weihuo Pan, Jianwei Zhang, Bo Zhao, Haohao Wang, Fanlong Liu, Ketao Jin, Xiaozhou Mou
Heterogeneity in primary tumor and related metastases may result in different response to anticancer therapy. Previous work revealed that there were heterogeneity in primary colon carcinoma and matched lymphatic and hepatic metastases. Subsequent study further ascertained the different expression of some functional genes in primary colon carcinoma and paired hepatic metastases in a larger group of patients with metastatic colon carcinoma. However, whether such heterogeneity in primary colon carcinoma and corresponding lymphatic and hepatic metastases would result in different response to anticancer therapy is unknown...
September 12, 2013: Hepato-gastroenterology
https://www.readbyqxmd.com/read/23988381/establishment-of-a-patient-derived-wilms-tumor-xenograft-model-a-promising-tool-for-individualized-cancer-therapy
#5
Mohammad-Javad Mohseni, Saeid Amanpour, Samad Muhammadnejad, Shabnam Sabetkish, Ahad Muhammadnejad, Reza Heidari, Mahnaz Haddadi, Zohreh Mazaheri, Mohammad Vasei, Abdol-Mohammad Kajbafzadeh
OBJECTIVE: Lack of appropriate approaches that reliably predict response of Wilms' tumor (WT) to anticancer agents remains a major deficiency in clinical practice of individualized cancer therapy. The aim of this study was to establish a patient-derived tumor tissue (PDTT) xenograft model of WT for individualized chemotherapeutic regimen selection in accordance with the patient's tumor nature. MATERIAL AND METHODS: Tumor specimens of a primary WT were orthotopically implanted into three nude mice, and after 4 weeks xenografts were harvested for serial heterotopic transplantation in 20 nude mice that were divided into three experimental groups and one control group...
February 2014: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/22783390/antitumor-effect-of-fp3-in-a-patient-derived-tumor-tissue-xenograft-model-of-gastric-carcinoma-through-an-antiangiogenic-mechanism
#6
Ketao Jin, Huanrong Lan, Feilin Cao, Zhenzhen Xu, Na Han, Guangliang Li, Kuifeng He, Lisong Teng
FP3 (KH902/KH903) is a novel vascular endothelial growth factor (VEGF) blocker with antiangiogenic properties. Previous studies revealed that FP3, a humanized fusion protein that combines ligand binding elements from the extracellular domains of VEGF receptors 1 and 2 and the Fc portion of IgG1, has an inhibitory effect on the VEGF-mediated proliferation and migration of human umbilical vein endothelial cells, and VEGF-mediated vessel sprouting of rat aortic rings in vitro. Thus, FP3 was considered as a new promising agent in treating human choroidal neovascularization (CNV) caused by age-related macular degeneration (AMD)...
May 2012: Oncology Letters
https://www.readbyqxmd.com/read/22617773/antitumor-effects-of-fp3-in-combination-with-capecitabine-on-pdtt-xenograft-models-of-primary-colon-carcinoma-and-related-lymphatic-and-hepatic-metastases
#7
Ketao Jin, Huanrong Lan, Bojian Xie, Kuifeng He, Zhenzhen Xu, Guangliang Li, Na Han, Lisong Teng, Feilin Cao
FP3 is an engineered protein which contains the extracellular domain 2 of VEGF receptor 1 (Flt-1) and extracellular domain 3 and 4 of VEGF receptor 2 (Flk-1, KDR) fused to the Fc portion of human immunoglobulin G 1. Previous studies demonstrated its antiangiogenic effects in vitro and in vivo, and its antitumor activity in vivo. In this study, patient-derived tumor tissue (PDTT) xenograft models of primary colon carcinoma and lymphatic and hepatic metastases were established for assessment of the antitumor activity of FP3 in combination with capecitabine...
July 2012: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/22581265/differential-response-to-egfr-and-vegf-targeted-therapies-in-patient-derived-tumor-tissue-xenograft-models-of-colon-carcinoma-and-related-metastases
#8
Ketao Jin, Huanrong Lan, Feilin Cao, Na Han, Zhenzhen Xu, Guangliang Li, Kuifeng He, Lisong Teng
Heterogeneity in primary tumors and related metastases may result in failure of antitumor therapies, particularly in targeted therapies for the treatment of cancer. In this study, patient-derived tumor tissue (PDTT) xenograft models of colon carcinoma with lymphatic and hepatic metastases were used to evaluate the response to EGFR- and VEGF-targeted therapies. Our results showed that primary colon carcinoma and its corresponding lymphatic and hepatic metastases have a different response rate to anti-EGFR (cetuximab) and anti-VEGF (bevacizumab) therapies...
August 2012: International Journal of Oncology
https://www.readbyqxmd.com/read/22505231/antitumor-effect-of-fp3-in-combination-with-cetuximab-on-patient-derived-tumor-tissue-xenograft-models-of-primary-colon-carcinoma-and-related-lymphatic-and-hepatic-metastases
#9
Xiaofang Dong, Ketao Jin, Xiaoyan Hu, Fangmin Du, Huanrong Lan, Na Han, Zhaosheng Ma, Bojian Xie, Binbin Cui, Lisong Teng, Feilin Cao
FP3 is an engineered protein which contains the extracellular domain 2 of vascular endothelial growth factor (VEGF) receptor 1 (Flt-1) and the extracellular domain 3 and 4 of VEGF receptor 2 (Flk-1, KDR) fused to the Fc portion of human immunoglobulin G1. Previous studies have demonstrated its antiangiogenic effects in vitro and in vivo, and its antitumor activity in vivo. Cetuximab is a monoclonal antibody against epidermal growth factor (EGF) receptor. Combined inhibition of VEGF and EGF signaling may act additively or synergistically...
July 2012: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/22164281/assessment-of-a-novel-vegf-targeted-agent-using-patient-derived-tumor-tissue-xenograft-models-of-colon-carcinoma-with-lymphatic-and-hepatic-metastases
#10
Ketao Jin, Guangliang Li, Binbin Cui, Jing Zhang, Huanrong Lan, Na Han, Bojian Xie, Feilin Cao, Kuifeng He, Haohao Wang, Zhenzhen Xu, Lisong Teng, Tieming Zhu
The lack of appropriate tumor models of primary tumors and corresponding metastases that can reliably predict for response to anticancer agents remains a major deficiency in the clinical practice of cancer therapy. It was the aim of our study to establish patient-derived tumor tissue (PDTT) xenograft models of colon carcinoma with lymphatic and hepatic metastases useful for testing of novel molecularly targeted agents. PDTT of primary colon carcinoma, lymphatic and hepatic metastases were used to create xenograft models...
2011: PloS One
https://www.readbyqxmd.com/read/21940303/establishment-of-a-pdtt-xenograft-model-of-gastric-carcinoma-and-its-application-in-personalized-therapeutic-regimen-selection
#11
Ketao Jin, Kuifeng He, Na Han, Guangliang Li, Haohao Wang, Zhenzhen Xu, Haiping Jiang, Jing Zhang, Lisong Teng
BACKGROUND/AIMS: Lack of appropriate tumor models that reliably predict response to anticancer agents remains a major deficiency in the clinical practice of personalized cancer therapy. The aim of our study was to establish a patient-derived tumor tissue (PDTT) xenograft model of gastric carcinoma for personalized cancer therapeutic regimen selection and testing of novel molecularly targeted agents. METHODOLOGY: Patient-derived tumor tissue of primary gastric carcinoma was used to create the xenograft model...
September 2011: Hepato-gastroenterology
https://www.readbyqxmd.com/read/20615824/patient-derived-human-tumour-tissue-xenografts-in-immunodeficient-mice-a-systematic-review
#12
REVIEW
Ketao Jin, Lisong Teng, Yanping Shen, Kuifeng He, Zhenzhen Xu, Guangliang Li
Mouse cancer models have consistently been used to qualify new anticancer drugs in the development of human clinical trials. Rodent tumour models currently being used and which include transgenic tumour models, and those generated by planting human tumour cell lines subcutaneously in immunodeficient mice, do not sufficiently represent clinical cancer characteristics, especially with regard to metastasis and drug sensitivity. The increasingly used patient-derived human tumour tissue (PDTT) xenografts models implanted subcutaneously or in subrenal capsule in immunodeficient mice, such as athymic nude mice or severe combined immunedeficient (SCID) mice, may provide a more accurate reflection of human tumour biological characteristics than tumour cell lines...
July 2010: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/20510302/photodynamic-applications-in-brain-tumors-a-comprehensive-review-of-the-literature
#13
REVIEW
Sam Eljamel
INTRODUCTION: GBM is the comment glioma. GBM-outcome had not changed much over two decades despite leaps in medical technology. Fewer than 25% survive 2 years. There is no jacket that fits all GBMs. This paper reviews the evidence for PDT in GBMs. RATIONALE: Maximum safe resection is supported by level-II evidence. PDT-technology (PDTT) provides means to maximize safe resection. PDTT paints GBM red in contrast to brain because of selective uptake and retention of photosensitizers...
June 2010: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/18961123/6-phenyl-2-3-dihydro-assym-triazine-3-thione-and-5-6-diphenyl-2-3-dihydro-asym-triazine-3-thione-as-gravimetric-reagents-for-the-determination-of-thallium-and-palladium
#14
M Edrissi, A Massoumi, I Lalezari
The analytical use of 6-phenyl-2,3-dihydro-asym-triazine-3-thione (PDTT) and 5,6-diphenyl-2,3-dihydro-asym-triazine-3-thione (DDTT) has been investigated. PDTT proved to be suitable for the determination of thallium(I) in the presence of cyanide whereas DDTT is more selective than PDTT in alkaline tartrate solution and is applied for the selective gravimetric determination of palladium. The method is more sensitive than the dimethylglyoxime method. The only metal ions interfering are Hg(II), Ag and Tl(I).
June 1972: Talanta
https://www.readbyqxmd.com/read/12885392/spray-dried-redispersible-oil-in-water-emulsion-to-improve-oral-bioavailability-of-poorly-soluble-drugs
#15
COMPARATIVE STUDY
Gilles Dollo, Pascal Le Corre, Alexis Guérin, François Chevanne, Jean Louis Burgot, Roger Leverge
A physically stabilized dry emulsion dosage form reforming the original emulsion after rehydration was developed by spray-drying a liquid oil-in-water emulsion containing maltodextrin as carrier and sodium caseinate as emulsifying agent. Several oil:water as well as maltodextrin:water ratios were tested, the homogenization and spray-drying processes and the reconstitution properties were investigated and an optimum formulation was selected for poorly soluble drug incorporation, having an identical oil:water and carrier:water ratio of 10% (w/w) and a load of solid material of 20% (w/w)...
July 2003: European Journal of Pharmaceutical Sciences
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