keyword
https://read.qxmd.com/read/36161908/the-unusual-convergence-of-steroid-catabolic-pathways-in-mycobacterium-abscessus
#21
JOURNAL ARTICLE
Adam M Crowe, Jessica M C Krekhno, Kirstin L Brown, Jayesh A Kulkarni, Katherine C Yam, Lindsay D Eltis
Mycobacterium abscessus , an opportunistic pathogen responsible for pulmonary infections, contains genes predicted to encode two steroid catabolic pathways: a cholesterol catabolic pathway similar to that of Mycobacterium tuberculosis and a 4-androstenedione (4-AD) catabolic pathway. Consistent with this prediction, M. abscessus grew on both steroids. In contrast to M. tuberculosis , Rhodococcus jostii RHA1, and other Actinobacteria, the cholesterol and 4-AD catabolic gene clusters of the M. abscessus complex lack genes encoding HsaD, the meta -cleavage product (MCP) hydrolase...
October 4, 2022: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/35969055/a-novel-leucyl-trna-synthetase-inhibitor-mrx-6038-expresses-anti-mycobacterium-abscessus-activity-in-vitro-and-in-vivo
#22
JOURNAL ARTICLE
Wenye Wu, Siyuan He, Anqi Li, Qi Guo, Zhili Tan, Shicong Liu, Xinghai Wang, Zhemin Zhang, Bing Li, Haiqing Chu
Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed. The anti-M. abscessus activity of MRX-6038, a new leucyl-tRNA synthetase inhibitor, was evaluated in vitro and in vivo . Antimicrobial susceptibility testing was performed on 12 nontuberculosis mycobacteria (NTM) reference strains and 227 clinical NTM isolates. A minimum bactericidal concentration assay was conducted to distinguish the bactericidal versus bacteriostatic activity of MRX-6038. The synergy between MRX-6038 and 12 clinically important antibiotics was determined using a checkerboard assay...
August 15, 2022: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/35950771/short-signature-rpob-gene-sequence-to-differentiate-species-in-mycobacterium-abscessus-group
#23
JOURNAL ARTICLE
Jian R Bao, Kileen L Shier, Ronald N Master, Robert S Jones, Richard B Clark
Mycobacterium abscessus group (MAG) are rapidly growing acid-fast bacteria that consist of three closely related species: M. abscessus ( Ma ), M. bolletii ( Mb ), and M. massiliense ( Mm ). Differentiation of these species can be difficult but is increasingly requested owing to recent infectious outbreaks and their differential drug resistance. We developed a novel and rapid pyrosequencing method using short signature sequences (35 to 45 bp) at a hypervariable site in the rpoB gene to differentiate the three MAG species, along with M...
August 11, 2022: Microbiology Spectrum
https://read.qxmd.com/read/35890022/a-review-on-mycobacteriophages-from-classification-to-applications
#24
REVIEW
Sepideh Hosseiniporgham, Leonardo A Sechi
Mycobacterial infections are a group of life-threatening conditions triggered by fast- or slow-growing mycobacteria. Some mycobacteria, such as Mycobacterium tuberculosis, promote the deaths of millions of lives throughout the world annually. The control of mycobacterial infections is influenced by the challenges faced in the diagnosis of these bacteria and the capability of these pathogens to develop resistance against common antibiotics. Detection of mycobacterial infections is always demanding due to the intracellular nature of these pathogens that, along with the lipid-enriched structure of the cell wall, complicates the access to the internal contents of mycobacterial cells...
July 7, 2022: Pathogens
https://read.qxmd.com/read/35888565/periocular-infection-of-mycobacterium-avium-complex-in-a-patient-with-interferon-%C3%AE-autoantibodies-a-case-report
#25
Tzu-Hui Lo, Tou-Yuan Tsai, Lih-Shinn Wang, Tzu-Lun Huang, Nancy Chen
The neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging entity frequently associated with the nontuberculosis mycobacterium (NTM) infection and other opportunistic infections. We present a female patient with a mysterious periocular Mycobacterium avium complex (MAC) infection, accompanied by sequential opportunistic infections including Salmollelosis and herpes zoster infection. Her condition stabilized after long-term antimycobacterial treatment. Nevertheless, neutralizing anti-interferon-γ autoantibody was found in her serum, which was compatible with the scenario of adult-onset immunodeficiency...
June 24, 2022: Medicina
https://read.qxmd.com/read/35775546/investigation-of-species-distribution-of-nontuberculosis-mycobacteria-isolated-from-sputum-samples-in-patients-with-suspected-pulmonary-tuberculosis
#26
JOURNAL ARTICLE
Serihan K Bra Emikoglu Cerit, G Lnur Tarhan, Ismail Ceyhan
Aims: Rapid and accurate identification of mycobacteria is important for the species-specific treatment of the disease. The aim of this study was the identification at the species level of 34 nontuberculous mycobacteria strains isolated from respiratory tract samples and 14 reference strains as by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Materials and Methods: Isolates derived from clinical specimens were subcultured in the Lowenstein-Jensen medium...
April 2022: International Journal of Mycobacteriology
https://read.qxmd.com/read/35708979/-in-vitro-activity-of-fidaxomicin-against-nontuberculosis-mycobacteria
#27
JOURNAL ARTICLE
Qing Sun, Xinlei Liao, Chenqian Wang, Guanglu Jiang, Jing Yang, Jianhong Zhao, Hairong Huang, Guirong Wang, Hao Li
Introduction. Nontuberculous mycobacteria (NTM) infections are increasing worldwide and are relatively resistant to many of the first- and second-line drugs to treat tuberculosis. Macrolide antibiotics, such as clarithromycin and azithromycin, are the key drugs for treating NTM infections. Fidaxomicin is a macrolide antibiotic that is widely used in treating Clostridium difficle (C.difficile) infections, and has high in vitro activity against Mycobacterium tuberculosis especially multidrug-resistant tuberculosis (MDR-TB) and has no cross-resistance with rifampicin...
June 2022: Journal of Medical Microbiology
https://read.qxmd.com/read/35682679/progression-and-dissemination-of-pulmonary-mycobacterium-avium-infection-in-a-susceptible-immunocompetent-mouse-model
#28
JOURNAL ARTICLE
Raymond Rosenbloom, Igor Gavrish, Anna E Tseng, Kerstin Seidel, Shivraj M Yabaji, Hans P Gertje, Bertrand R Huber, Igor Kramnik, Nicholas A Crossland
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallmark of MAC lung infection, yet reliable correlates of disease progression, susceptibility, and resolution are poorly defined. Unlike widely used inbred mouse strains, mice that carry the mutant allele at the genetic locus sst1 develop human-like pulmonary tuberculosis featuring well-organized caseating granulomas...
May 26, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35487186/breath-biomarkers-associated-with-nontuberculosis-mycobacteria-disease-status-in-persons-with-cystic-fibrosis-a-pilot-study
#29
JOURNAL ARTICLE
Ahmad Mani-Varnosfaderani, Antao Gao, Katie R Poch, Silvia M Caceres, Jerry A Nick, Jane E Hill
Pulmonary infections caused by mycobacteria cause significant mortality and morbidity in the human population. Diagnosing mycobacterial infections is challenging. An infection can lead to active disease or remain indolent with little clinical consequence. In patients with pulmonary non-tuberculosis Mycobacteria (PNTM) identification of infection and diagnosis of disease can take months to years. Our previous studies showed the potential diagnostic power of volatile molecules in the exhaled breath samples to detect active pulmonary Mycobacterium tuberculosis infection...
April 29, 2022: Journal of Breath Research
https://read.qxmd.com/read/35324861/mixed-infection-of-mycobacterium-szulgai-m-lentiflavum-and-gram-negative-bacteria-as-a-cause-of-death-in-a-brown-caiman-caiman-crocodylus-a-case-report
#30
Aleksandra Maluta, Magdalena Zając, Monika Krajewska-Wędzina, Dariusz Wasyl, Kim Heckers, Anna Didkowska, Krzysztof Anusz
This paper describes a fatal case of nontuberculosis mycobacteriosis in a four-year-old brown caiman kept in captivity. Although the clinical signs were asymptomatic, severe gross lesions were observed, namely necrotic inflammation of the intestines and granulomatous hepatitis. Microbiological and histopathological examination performed on the tissues collected postmortem revealed a mixed infection of Mycobacterium lentiflavum and Mycobacterium szulgai , secondarily mimicked with Salmonella Coeln , Aeromonas hydrofila , Citrobacter freundii , and Providencia rettgeri ...
March 13, 2022: Veterinary Sciences
https://read.qxmd.com/read/35036014/probably-the-mycobacterium-avium-complex-around-the-staple-line-exacerbated-after-radiation-therapy
#31
Masashi Ito, Akihiro Yoshii, Takashi Osaki, Tomohito Kuwako, Ei Yamaki, Osamu Kawashima
The space around the staple line after lung surgery is at high risk of nontuberculosis Mycobacterium pulmonary disease (NTM-PD). Solitary nodules of NTM-PD around the staple line are difficult to distinguish from lung cancer. There is no clear identification from laboratory data and radiologic findings without histological examination. In the present case, we misdiagnosed the pulmonary granulomas with Mycobacterium avium complex pulmonary disease (MAC-PD) as a recurrence of lung cancer. We conducted radiation therapy...
2022: Case Reports in Infectious Diseases
https://read.qxmd.com/read/34916451/the-role-of-interferon-gamma-and-interferon-gamma-receptor-in-tuberculosis-and-nontuberculous-mycobacterial-infections
#32
REVIEW
Jalaledin Ghanavi, Poopak Farnia, Parissa Farnia, Ali Akbar Velayati
Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) remain the leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its receptor (IFN-γR) play a key role in mediating immunity against Mtb and NTM. This study was conducted as a systematic review; all information was collected from databases such as: PubMed, Scopus, Medline, SID, and medical databases. Finally, all the collected data were reviewed, and all content was categorized briefly. There is growing evidence that IFN-γ plays an important role in host defense against these two intracellular pathogens by activating macrophages...
October 2021: International Journal of Mycobacteriology
https://read.qxmd.com/read/34869812/disseminated-cutaneous-mycobacterium-chelonae-infection-as-a-presenting-sign-of-ectopic-adrenocorticotropic-hormone-syndrome
#33
Meredith A Park, Lindsey J Gaghan, Paul B Googe, Klara R Klein, Julie E Mervak
No abstract text is available yet for this article.
December 2021: JAAD Case Reports
https://read.qxmd.com/read/34558476/rare-manifestation-of-ocular-immune-reconstitution-inflammatory-syndrome-from-mycobacterium-scrofulaceum-infection-in-a-patient-with-aids
#34
Thanin Jiamjunkupt, Nathamon Sasiprapha, Dhitiwat Changpradub, Raveewan Choontanom, Wiwan Sansanayudh
Immune reconstitution inflammatory syndrome (IRIS) is a common complication following the initiation of antiretroviral therapy (ART). The most commonly associated pathogens include Mycobacterium tuberculosis and Cryptococcus spp.[1] IRIS following nontuberculosis mycobacteria (NTM) infection is uncommon, particularly, IRIS following NTM conjunctivitis.[2] Herein, we present a case of Mycobacterium scrofulaceum conjunctivitis with peripheral ulcerative keratitis and orbital cellulitis in a 45-year-old patient with AIDS who developed IRIS 1 month after starting ART therapy...
April 2021: International Journal of Mycobacteriology
https://read.qxmd.com/read/34424857/epidemiology-of-nontuberculous-mycobacterial-infection-in-tuberculosis-suspects
#35
JOURNAL ARTICLE
Parasmal Suresh, Anil Kumar, Raja Biswas, Divya Vijayakumar, Swathy Thulasidharan, Gopikrishnan Anjaneyan, Akhilesh Kunoor, Lalitha Biswas
Nontuberculosis mycobacteria (NTM) are opportunistic pathogens that cause a wide range of illnesses. Here, the species distribution and prevalence of NTM infections in tuberculosis suspects was analyzed. A total of 7,073 specimens from pulmonary and extrapulmonary sites were analyzed, and 709 (10%) were found to be culture positive for mycobacteria. Of these, 85.2% were identified as Mycobacterium tuberculosis complex and 14.8% as NTM (65.7% rapid growers and 34.3% slow growers). Speciation of the NTM isolates (n = 69) identified 19 NTM species...
August 23, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/34355905/modulation-of-a-mycobacterial-adp-ribosyltransferase-to-augment-rifamycin-antibiotic-resistance
#36
JOURNAL ARTICLE
Meng Zheng, Tania J Lupoli
The rifamycins are broad-spectrum antibiotics that are primarily utilized to treat infections caused by mycobacteria, including tuberculosis. Interestingly, various species of bacteria are known to contain an enzyme called Arr that catalyzes ADP-ribosylation of rifamycin antibiotics as a mechanism of resistance. Here, we study Arr modulation in relevant Gram-positive and -negative species. We show that a C-terminal truncation of Arr (ArrC ), encoded in the genome of Mycobacterium smegmatis , activates Arr-mediated rifamycin modification...
August 6, 2021: ACS Infectious Diseases
https://read.qxmd.com/read/34314150/nanoparticulate-%C3%AE-cyclodextrin-with-gallium-tetraphenylporphyrin-demonstrates-in-vitro-and-in-vivo-antimicrobial-efficacy-against-mycobacteroides-abscessus-and-mycobacterium-avium
#37
JOURNAL ARTICLE
Seoung-Ryoung Choi, Geoffrey A Talmon, Bradley E Britigan, Prabagaran Narayanasamy
The emergence of drug-resistant pathogens causes the greatest challenge for drug development research. Recently, gallium(III)-based compounds have received great attention as novel antimicrobial agents against drug-resistant pathogens. Here, we synthesized a new β-cyclodextrin Ga nanoparticle (CDGaTP) using Ga tetraphenylporphyrin (GaTP, a hemin analogue) and β-cyclodextrin. The newly synthesized nanoparticle was nontoxic and efficient at a single dose, showing sustained drug release for 15 days in vitro...
July 27, 2021: ACS Infectious Diseases
https://read.qxmd.com/read/34310615/in-vitro-activity-of-spr719-against-mycobacterium-ulcerans-mycobacterium-marinum-and-mycobacterium-chimaera
#38
JOURNAL ARTICLE
Sacha J Pidot, Jessica L Porter, Troy Lister, Timothy P Stinear
Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate the in vitro activity of SPR719, a novel aminobenzimidazole antibiotic and the active form of the clinical-stage compound, SPR720, against several isolates of Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera...
July 26, 2021: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/34237018/direct-molecular-characterization-of-acid-fast-bacilli-smear-of-nontuberculosis-mycobacterium-species-causing-pulmonary-tuberculosis-in-guna-yala-region-panama
#39
JOURNAL ARTICLE
Arístides López, Fermin Acosta, Dilcia Sambrano, Musharaf Tarajia, Sophia Navajas, Florentino Arias, Baudilio Escobar, Porfirio Ortis, Fidel Adames, Amador Goodridge
Mycobacterium tuberculosis (MTB) stands out as the main causative agent of pulmonary tuberculosis (TB). However, nontuberculous mycobacteria (NTM) species also have the potential to infect and cause TB in susceptible individuals. The objective of this study was to identify NTM species that cause public health problems in remote areas. The study was carried out using 105 sputum smears obtained from patients from the Guna Yala Region of Panama with clinical signs suggestive of TB. DNA was extracted from sputum smears...
July 8, 2021: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/33713043/the-double-edged-sword-of-tregs-in-m-tuberculosis-m-avium-and-m-absessus-infection
#40
REVIEW
Deepshikha Verma, Edward D Chan, Diane J Ordway
Immunity against different Mycobacteria species targeting the lung requires distinctly different pulmonary immune responses for bacterial clearance. Many parameters of acquired and regulatory immune responses differ quantitatively and qualitatively from immunity during infection with Mycobacteria species. Nontuberculosis Mycobacteria species (NTM) Mycobacterium avium- (M avium), Mycobacterium abscessus-(M abscessus), and the Mycobacteria species Mycobacterium tuberculosis-(Mtb). Herein, we discuss the potential implications of acquired and regulatory immune responses in the context of animal and human studies, as well as future directions for efforts to treat Mycobacteria diseases...
May 2021: Immunological Reviews
keyword
keyword
40447
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.