Raymond Rosenbloom, Igor Gavrish, Anna E Tseng, Kerstin Seidel, Shivraj M Yabaji, Hans P Gertje, Bertrand R Huber, Igor Kramnik, Nicholas A Crossland
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is the hallmark of MAC lung infection, yet reliable correlates of disease progression, susceptibility, and resolution are poorly defined. Unlike widely used inbred mouse strains, mice that carry the mutant allele at the genetic locus sst1 develop human-like pulmonary tuberculosis featuring well-organized caseating granulomas...
May 26, 2022: International Journal of Molecular Sciences