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https://www.readbyqxmd.com/read/28749580/dopamine-transporter-neuroimaging-as-an-enrichment-biomarker-in-early-parkinson-s-disease-clinical-trials-a-disease-progression-modeling-analysis
#1
Daniela J Conrado, Timothy Nicholas, Kuenhi Tsai, Sreeraj Macha, Vikram Sinha, Julie Stone, Brian Corrigan, Massimo Bani, Pierandrea Muglia, Ian A Watson, Volker D Kern, Elena Sheveleva, Kenneth Marek, Diane T Stephenson, Klaus Romero
Given the recognition that disease-modifying therapies should focus on earlier Parkinson's disease stages, trial enrollment based purely on clinical criteria poses significant challenges. The goal herein was to determine the utility of dopamine transporter neuroimaging as an enrichment biomarker in early motor Parkinson's disease clinical trials. Patient-level longitudinal data of 672 subjects with early-stage Parkinson's disease in the Parkinson's Progression Markers Initiative (PPMI) observational study and the Parkinson Research Examination of CEP-1347 Trial (PRECEPT) clinical trial were utilized in a linear mixed-effects model analysis...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28749071/hepatic-subcapsular-hematoma-breaking-into-the-abdominal-cavity-after-extracorporeal-shock-wave-lithotripsy-for-pancreatic-stones
#2
Bi Ya Wei, Dan Wang, Ting Ting Du, Zhuan Liao, Zhao Shen Li, Liang Hao Hu
Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) has been recommended for the management of large pancreatic stones. It is considered to be a noninvasive and low morbidity procedure. However, despite its minimal invasiveness, it does have complications.
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28748811/the-obesity-paradox-what-does-it-mean-for-lung-cancer-surgery
#3
EDITORIAL
Emily Stone, Christopher G Slatore
No abstract text is available yet for this article.
August 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28748474/absolute-quantification-of-toxicological-biomarkers-via-mass-spectrometry
#4
Thomas Y K Lau, Ben C Collins, Peter Stone, Ning Tang, William M Gallagher, Stephen R Pennington
With the advent of "-omics" technologies there has been an explosion of data generation in the field of toxicology, as well as many others. As new candidate biomarkers of toxicity are being regularly discovered, the next challenge is to validate these observations in a targeted manner. Traditionally, these validation experiments have been conducted using antibody-based technologies such as Western blotting, ELISA, and immunohistochemistry. However, this often produces a significant bottleneck as the time, cost, and development of successful antibodies are often far outpaced by the generation of targets of interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28746854/effect-of-hydrodynamic-interactions-on-reaction-rates-in-membranes
#5
Naomi Oppenheimer, Howard A Stone
The Brownian motion of two particles in three dimensions serves as a model for predicting the diffusion-limited reaction rate, as first discussed by von Smoluchowski. Deutch and Felderhof extended the calculation to account for hydrodynamic interactions between the particles and the target, which results in a reduction of the rate coefficient by about half. Many chemical reactions take place in quasi-two-dimensional systems, such as on the membrane or surface of a cell. We perform a Smoluchowski-like calculation in a quasi-two-dimensional geometry, i...
July 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28746535/a-storm-of-stones-in-the-lungs-an-uncommon-sequela-of-varicella-pneumonia
#6
Gaetano Rea, Adriano Costigliola, Cecilia Calabrese
No abstract text is available yet for this article.
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28746326/giant-sialolith-of-submandibular-duct
#7
P Sakthivel, R Yogal, S Singh, P Sharma, C A Singh
Sialolithiasis is one of the most common diseases of salivary glands and commonly involves submandibular gland and ducts. "Giant sialoliths" typically measure more than 15 mm in any dimension. Here, an unusual case of sialolith in submandibular duct is reported which progressed into a giant sialolith in six months' time is reported. A 42-year-old man presented with complaints of recurrent pain and swelling in the right submandibular area. A large stone was palpable intraorally within the Wharton's duct and intra-operatively, an elongated giant sialolith of 50 mm length was found which is the second largest to be published till date...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28745999/trial-of-tocilizumab-in-giant-cell-arteritis
#8
John H Stone, Katie Tuckwell, Sophie Dimonaco, Micki Klearman, Martin Aringer, Daniel Blockmans, Elisabeth Brouwer, Maria C Cid, Bhaskar Dasgupta, Juergen Rech, Carlo Salvarani, Georg Schett, Hendrik Schulze-Koops, Robert Spiera, Sebastian H Unizony, Neil Collinson
BACKGROUND: Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis. METHODS: In this 1-year trial, we randomly assigned 251 patients, in a 2:1:1:1 ratio, to receive subcutaneous tocilizumab (at a dose of 162 mg) weekly or every other week, combined with a 26-week prednisone taper, or placebo combined with a prednisone taper over a period of either 26 weeks or 52 weeks...
July 27, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28745038/bilateral-endoscopic-surgery-for-renal-stones-a-systematic-review-of-the-literature
#9
Silvia Proietti, Jean de la Rosette, Brian Eisner, Franco Gaboardi, Cristian Fiori, Ella Kinzikeeva, Lorenzo Luciani, Roberto Miano, Francesco Porpiglia, Marco Rosso, Mario Sofer, Olivier Traxer, Guido Giusti
INTRODUCTION: The aim of this study was to evaluate the current literature on single-session bilateral endoscopic surgery for renal stones, analyzing their effectiveness and safety. EVIDENCE ACQUISITION: A systematic literature review was performed to identify articles published between 1995 and July 2016 that reported data on bilateral single-session endoscopic surgery for renal stones. Articles were separated into the following categories: bilateral PCNL, bilateral FURS and bilateral PCNL with contralateral FURS...
October 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28744695/update-of-the-icud-siu-consultation-on-stone-technology-behind-ureteroscopy
#10
Jonathan Cloutier, Ken Anson, Guido Giusti, Michael Grasso, Guido Kamphuis, Sven Lahme, Evangelos Liatsikos, Anup Patel, Margaret S Pearle, Luc Valiquette, Olivier Traxer
INTRODUCTION: Ureteroscopy is now the most frequent treatment used around the world for stone disease. Technological advancement, efficiency, safety, and minimally invasiveness of this procedure are some of the reasons for this change of trend. MATERIALS AND METHODS: In this review of the literature, a search of the PubMed database was conducted to identify articles related to ureteroscopy and accessories. The committee assigned by the International Consultation on Urological Disease reviewed all the data and produced a consensus statement relating to the ureteroscopy and all the particularities around this procedure...
July 25, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28744072/multimodality-imaging-spectrum-of-complications-of-horseshoe-kidney
#11
Hardik U Shah, Vijayanadh Ojili
Horseshoe kidney is the most common congenital renal fusion anomaly with an incidence of 1 in 400-600 individuals. The most common type is fusion at the lower poles seen in greater than 90% of the cases, with the rest depicting fusion at the upper poles, resulting in an inverted horseshoe kidney. Embryologically, there are two theories hypothesizing the genesis of horseshoe kidney - mechanical fusion theory and teratogenic event theory. As an entity, horseshoe kidney is an association of two anatomic anomalies, namely, ectopia and malrotation...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28743753/spatial-gene-drives-and-pushed-genetic-waves
#12
Hidenori Tanaka, Howard A Stone, David R Nelson
Gene drives have the potential to rapidly replace a harmful wild-type allele with a gene drive allele engineered to have desired functionalities. However, an accidental or premature release of a gene drive construct to the natural environment could damage an ecosystem irreversibly. Thus, it is important to understand the spatiotemporal consequences of the super-Mendelian population genetics before potential applications. Here, we use a reaction-diffusion model for sexually reproducing diploid organisms to study how a locally introduced gene drive allele spreads to replace the wild-type allele, although it possesses a selective disadvantage s > 0...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28743528/contrast-enhanced-ultrasound-as-a-radiation-free-alternative-to-fluoroscopic-nephrostogram-for-evaluating-ureteral-patency
#13
Thomas Chi, Manint Usawachintachit, Stefanie Weinstein, Maureen P Kohi, Andrew Taylor, David T Tzou, Helena C Chang, Marshall Stoller, John Mongan
PURPOSE: To compare contrast-enhanced ultrasound and fluoroscopic nephrostography in the evaluation of ureteral patency following percutaneous nephrolithotomy. MATERIALS AND METHODS: This was a prospective cohort non-inferiority study conducted after obtaining institutional review board approval. We enrolled eligible patients with kidney and proximal ureteral stones who underwent percutaneous nephrolithotomy at our center. On postoperative day 1, patients received both contrast-enhanced ultrasounds and fluoroscopic nephrostograms within 2 hours of each other to evaluate ureteral patency, the primary outcome for this study...
July 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28743527/effectiveness-and-complications-of-augmentation-cystoplasty-with-or-without-non-refluxing-ureteral-reimplantation-in-adult-patients-with-long-standing-bladder-dysfunction-a-single-center-11-year-experience-in-173-cases
#14
Zhaoxia Wang, Limin Liao
PURPOSE: To review our experience for effectiveness and complications of augmentation cystoplasty (AC) with or without non-refluxing ureteral reimplantation in adult patients with long-standing bladder dysfunction MATERIAL AND METHODS: We retrospectively reviewed 173 patients who underwent AC with or without ureteral re-implantation (UR) at our center from July 2005 to July 2016. Clinical data, magnetic resonance urography (MRU), and video-urodynamics (VUD) parameters were collected. The upper urinary tract dilation (UUTD) and vesicoureteral reflux (VUR) grading systems were used to evaluate upper urinary tract function...
July 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28742706/reply-to-the-letter-to-the-editor-aspirin-therapy-on-blood-transfusion-in-noncardiac-surgery-evidence-from-quality-effect-model
#15
Jesse A Columbo, Natalie B V Riblet, David H Stone
No abstract text is available yet for this article.
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742479/understanding-and-combating-resistance-to-online-learning
#16
John Vivolo
Resistance to change is an easy thing for human beings to understand. It is at the heart of our desire to find comfort with the familiar such as family, friends and our homes. We create homes that are designed a certain way and usually are slow to change. We make friends for years and keep those memories etched in stone, even though time and age create a romanticised version of the past. Change scares us so much that we reflect on our past, the old days, with such reverence that we paint over the ugly parts...
December 1, 2016: Science Progress
https://www.readbyqxmd.com/read/28741803/delayed-and-localized-sweets-syndrome-after-breast-cancer-radiotherapy
#17
Hiu Kwan Carolyn Tang, Doreen Yin Hui Lee, Ian Thompson, John R Ingram, Natalie Stone, Girish K Patel
No abstract text is available yet for this article.
July 25, 2017: Breast Journal
https://www.readbyqxmd.com/read/28741196/how-safe-is-performing-cholecystectomy-in-the-oldest-old-a-15-year-retrospective-study-from-a-single-institution
#18
Matteo Novello, Davide Gori, Salomone Di Saverio, Matteo Bianchin, Lorenzo Maestri, Francesco Vito Mandarino, Giuseppe Cavallari, Bruno Nardo
BACKGROUND: Globally, the number of people aged 80 years or over, the "oldest old," is the fastest growing population group. Because of the strong association between age and gallstone disease, both prevalence and incidence of this disease are increasing. The feasibility of the cholecystectomy in octogenarians has been evaluated in several studies that confirmed the safety of the operation. However, the safety of this procedure in nonagenarians is still controversial. The aim of this study was to evaluate the safety of cholecystectomies in nonagenarians and identify related predictors for postoperative hospital length of stay (LOS) and in-hospital mortality up to 30 days postoperatively...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740211/digging-up-food-excavation-stone-tool-use-by-wild-capuchin-monkeys
#19
Tiago Falótico, José O Siqueira, Eduardo B Ottoni
Capuchin monkeys at Serra da Capivara National Park (SCNP) usually forage on the ground for roots and fossorial arthropods, digging primarily with their hands but also using stone tools to loosen the soil and aid the digging process. Here we describe the stone tools used for digging by two groups of capuchins on SCNP. Both groups used tools while digging three main food resources: Thiloa glaucocarpa tubers, Ocotea sp roots, and trapdoor spiders. One explanation for the occurrence of tool use in primates is the "necessity hypothesis", which states that the main function of tool use is to obtain fallback food...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739807/organisation-of-care-for-pregnancy-in-patients-with-congenital-heart-disease
#20
REVIEW
Jolien W Roos-Hesselink, Werner Budts, Fiona Walker, Julie F A De Backer, Lorna Swan, William Stones, Peter Kranke, Karen Sliwa-Hahnle, Mark R Johnson
Improvements in surgery have resulted in more women with repaired congenital heart disease (CHD) surviving to adulthood. Women with CHD, who wish to embark on pregnancy require prepregnancy counselling. This consultation should cover several issues such as the long-term prognosis of the mother, fertility and miscarriage rates, recurrence risk of CHD in the baby, drug therapy during pregnancy, estimated maternal risk and outcome, expected fetal outcomes and plans for pregnancy. Prenatal genetic testing is available for those patients with an identified genetic defect using pregestational diagnosis or prenatal diagnosis chorionic villus sampling or amniocentesis...
July 24, 2017: Heart: Official Journal of the British Cardiac Society
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