keyword
MENU ▼
Read by QxMD icon Read
search

prokinetics

keyword
https://www.readbyqxmd.com/read/28090679/effect-of-prucalopride-on-intestinal-gas-tolerance-in-patients-with-functional-bowel-disorders-and-constipation
#1
Carolina Malagelada, Adoración Nieto, Sara Mendez, Anna Accarino, Javier Santos, Juan-R Malagelada, Fernando Azpiroz
BACKGROUND: Patients with functional bowel disorders develop gas retention and symptoms in response to intestinal gas loads that are well tolerated by healthy subjects. Stimulation of 5HT-4 receptors in the gut has both prokinetic and antinociceptive effects. AIM: To determine the effect of prucalopride, a highly selective 5HT-4 agonist, on gas transit and tolerance in women with functional bowel disorders complaining of constipation. METHODS: Twenty-four women with functional bowel disorders complaining of constipation were included in the study...
January 15, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28075092/diabetes-mellitus-management-of-gastrointestinal-complications
#2
Beth Careyva, Brian Stello
Gastrointestinal disorders are common complications of diabetes mellitus and include gastroparesis, nonalcoholic fatty liver disease, gastroesophageal reflux disease, and chronic diarrhea. Symptoms of gastroparesis include early satiety, postprandial fullness, nausea, vomiting of undigested food, bloating, and abdominal pain. Gastroparesis is diagnosed based on clinical symptoms and a delay in gastric emptying in the absence of mechanical obstruction. Gastric emptying scintigraphy is the preferred diagnostic test...
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28049258/the-impact-of-implementation-of-an-enteral-feeding-protocol-on-the-improvement-of-enteral-nutrition-in-critically-ill-adults
#3
Seoung-Hyun Kim, Chi-Min Park, Jeong-Meen Seo, Mingew Choi, Dae-Sang Lee, Dong Kyung Chang, Miyong Rha, Soyoung Yu, Seonhye Lee, Eunmee Kim, Young Yun Cho
BACKGROUND AND OBJECTIVES: The optimal delivery of enteral nutrition (EN) may improve clinical outcomes in critically ill patients; thus, optimal EN protocols should be developed. The purpose of this study was to evaluate the impact of implementing an EN protocol on the improvement of EN practices and on the clinical outcomes of critically ill patients. METHODS AND STUDY DESIGN: This was a retrospective study with prospectively collected data. Multidisciplinary working group developed an evidence-based EN protocol based on an extensive review of literature and existing guidelines...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28018097/contraindications-for-video-capsule-endoscopy
#4
REVIEW
Dirk Bandorski, Niehls Kurniawan, Peter Baltes, Reinhard Hoeltgen, Matthias Hecker, Dominik Stunder, Martin Keuchel
Video capsule endoscopy (VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27994692/incidental-findings-of-intense-radioiodine-uptake-in-struma-ovarii-and-bilateral-nonlactating-breasts-simultaneously-on-postablation-131-i-spect-ct-for-papillary-thyroid-cancer
#5
Hye-Kyung Shim, Mi Ra Kim
A 52-year-old woman diagnosed with papillary thyroid carcinoma was referred for (131)I therapy following total thyroidectomy. She was given 4,810 MBq (130 mCi) of (131)I following 4 weeks of thyroid hormone withdrawal. A posttherapy scan showed intense, focal activity in the pelvis and intense, diffuse activity on both sides of the chest, which was localized to the right ovary and both breasts on SPECT/CT examination. She had bilateral nipple pain and a history of antidopaminergic drugs as combination medication for her rheumatoid arthritis and prokinetics during radioiodine therapy...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27981311/mucosal-protective-compounds-in-the-treatment-of-gastroesophageal-reflux-disease-a-position-paper-based-on-evidence-of-the-romanian-society-of-neurogastroenterology
#6
Teodora Surdea-Blaga, Ion Băncilă, Daniela Dobru, Vasile Drug, Ovidiu Frățilă, Adrian Goldiș, Simona M Grad, Crina Mureșan, Laurențiu Nedelcu, Paul J Porr, Ioan Sporea, Dan L Dumitrascu
BACKGROUND AND AIMS: Gastroesophageal reflux disease (GERD) therapy is challenging and suppression of acid secretion or prokinetics do not cure all cases. Some drugs with protective action on the esophageal mucosa have been used alternatively or in association with proton pump inhibitors (PPIs) and/or prokinetics. The Romanian Society of Neurogastroenterology undertook an Evidence-Based analysis, from which this position paper evolved. METHODS: We performed a systematic literature search in PubMed until October 2015, using the terms: sucralfate, guaiazulene, gaiazulene, dimethicone, alginate, antacids and gastroesophageal reflux...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27940703/use-of-gastroesophageal-reflux-medications-in-premature-infants-after-nicu-discharge
#7
Jo Ann D'Agostino, Molly Passarella, Ashley E Martin, Scott A Lorch
OBJECTIVES: To describe the epidemiology and management of gastroesophageal reflux (GER) medications started in the first year of life for premature infants. METHODS: Retrospective review of a cohort of infants ≤35 weeks' gestation presenting for care by 168 days of age to a 30-site network between 2005 and 2009 (n = 2217) and followed to 3 years of age. Medication frequency, types, and duration of use were assessed. Logistic regression identified factors associated with treatment...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27914138/therapeutic-response-for-functional-abdominal-pain-in-children-with-occult-constipation-laxatives-versus-prokinetic-drugs
#8
Eun Kyo Ha, Homin Jang, Su Jin Jeong
The relationship between functional abdominal pain (FAP) and occult constipation (OC) in children who did not meet the Rome III criteria for constipation has rarely been reported. This study aimed to estimate the prevalence of OC in patients with FAP and to compare the effectiveness of prokinetic drugs and laxatives for FAP and OC. Pediatric outpatients (n = 212; aged 4-15 years) who satisfied the Rome III criteria for childhood FAP were divided into 2 groups based on Leech scores: group 1 < 8; group 2 ≥ 8...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27889808/pharmacodynamic-evaluation-of-lys-5-meleu-9-nle-10-nka-4-10-prokinetic-effects-on-bladder-and-colon-activity-in-acute-spinal-cord-transected-and-spinally-intact-rats
#9
F Aura Kullmann, M Katofiasc, K B Thor, Lesley Marson
The purpose of this study was to determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK2 receptor) agonist, Lys(5), MeLeu(9), Nle(10)-NKA(4-10) (LMN-NKA). Cystometry and colorectal pressure measurements were performed in urethane-anesthetized, intact, and acutely spinalized female rats. Bladder pressure and voiding were monitored in response to intravenous LMN-NKA given with the bladder filled to 70% capacity...
November 26, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27862707/pharmacotherapy-in-patients-with-pediatric-cipo-a-nationwide-survey-in-japan
#10
Naoki Hashizume, Minoru Yagi, Kosuke Ushijima, Yoshitaka Seki, Suguru Fukahori, Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi
PURPOSE: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by a severe impairment of gastrointestinal peristalsis. With respect to pharmacotherapy, while a number of agents have been developed, only a few trials have attempted to improve the pathological condition of patients with CIPO. This report presents the actual findings of pharmacotherapy in the patients with pediatric CIPO from the view point of a nationwide survey on the actual situation in Japan...
November 12, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27861438/cardiotoxic-antiemetics-metoclopramide-and-domperidone-block-cardiac-voltage-gated-na-channels
#11
Carsten Stoetzer, Marc Voelker, Thorben Doll, Joerg Heineke, Florian Wegner, Andreas Leffler
BACKGROUND: Metoclopramide and domperidone are prokinetic and antiemetic substances often used in clinical practice. Although domperidone has a more favorable side effect profile and is considered the first-line agent, severe cardiac side effects were reported during the administration of both substances. Cardiac Na channels are common targets of therapeutics inducing cardiotoxicity. Therefore, the aim of this study was to investigate whether the differential cardiotoxicities of metoclopramide and domperidone correlate with the block of Na channels...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27858187/duodeno-duodenostomy-or-duodeno-jejunostomy-for-duodenal-atresia-is-one-repair-better-than-the-other
#12
Augusto Zani, Jung-Pin Benjamin Yeh, Sebastian K King, Priscilla P L Chiu, Paul W Wales
PURPOSE: The surgical management of neonates with duodenal atresia (DA) involves re-establishment of intestinal continuity, either by duodeno-duodenostomy (DD) or by duodeno-jejunostomy (DJ). Although the majority of pediatric surgeons perform DD repair preferentially, we aimed to analyze the outcome of DA neonates treated with either surgical technique. METHODS: Following ethical approval (REB:1000047737), we retrospectively reviewed the charts of all patients who underwent DA repair between 2004 and 2014...
November 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27832682/effect-of-da-9701-a-novel-prokinetic-agent-on-post-operative-ileus-in-rats
#13
Sang Pyo Lee, Oh Young Lee, Kang Nyeong Lee, Hang Lak Lee, Ho Soon Choi, Byung Chul Yoon, Dae Won Jun
Background/Aims: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods: A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery/medication (NSM), surgery/no medication (SNM), and surgery/medication (SM)...
January 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#14
Jeffrey K Aronson
Inhibition of the H(+)/K(+)-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27734216/central-aspects-of-nausea-and-vomiting-in-gi-disorders
#15
REVIEW
Prashant Singh, Braden Kuo
Nausea and vomiting result from continuous interactions among gastrointestinal, central nervous system, and autonomic nervous system. Despite being closely associated, central pathways of nausea and vomiting appear to be at least partly different and nausea is no longer considered only a penultimate step of vomiting. Although our understanding of central pathways of nausea has improved over the last one decade, it is still very basic. Afferent pathways from gastrointestinal tract via vagus, vestibular system, and chemoreceptor trigger zone project to nucleus tractus solitarius which, in turn, relays the signal to central pattern generator initiating multiple downstream pathways...
December 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27730767/cardiovascular-autonomic-dysfunction-in-patients-with-drug-induced-parkinsonism
#16
Joong Seok Kim, Dong Woo Ryu, Ju Hee Oh, Yang Hyun Lee, Sung Jin Park, Kipyung Jeon, Jong Yun Lee, Seong Hee Ho, Jungmin So, Jin Hee Im, Kwang Soo Lee
BACKGROUND AND PURPOSE: Recent studies have shown that several nonmotor symptoms differ between Parkinson's disease (PD) and drug-induced parkinsonism (DIP). However, there have been no reports on cardiovascular autonomic function in DIP, and so this study investigated whether cardiovascular autonomic function differs between PD and DIP patients. METHODS: This study consecutively enrolled 20 DIP patients, 99 drug-naïve PD patients, and 25 age-matched healthy controls who underwent head-up tilt-table testing and 24-h ambulatory blood pressure monitoring...
October 7, 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27729771/pharmacokinetics-absorption-and-excretion-of-radiolabeled-revexepride-a-phase-i-clinical-trial-using-a-microtracer-and-accelerator-mass-spectrometry-based-approach
#17
Stephen Flach, Marie Croft, Jie Ding, Ron Budhram, Todd Pankratz, Mike Pennick, Graeme Scarfe, Steven Troy, Jay Getsy
PURPOSE: Gastroesophageal reflux disease involves the reflux of gastric and/or duodenal content into the esophagus. Prokinetic therapies, such as the selective 5-hydroxytryptamine receptor 4 agonist revexepride, may aid gastric emptying. This Phase I study evaluated the pharmacokinetics and excretion pathways of [(14)C]revexepride in healthy individuals using a microtracer approach with accelerator mass spectrometry. PARTICIPANTS AND METHODS: Six healthy men received a single oral dose of 2 mg [(14)C]revexepride containing ~200 nCi of radioactivity; blood, urine, and fecal samples were collected over a 10-day period...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27726068/newest-drugs-for-chronic-unexplained-nausea-and-vomiting
#18
REVIEW
William L Hasler
Chronic unexplained nausea and vomiting (CUNV) refers to a symptom complex defined by nausea and/or vomiting with normal diagnostic testing, including anatomic assessments (including upper endoscopy) and measures of upper gut function (e.g., gastric emptying testing). Nausea and vomiting in this condition are postulated to result from aberrant peripheral or central neurohumoral activity. A substantial subset of patients satisfies this diagnosis as more than half of individuals referred for scintigraphic testing exhibit normal gastric emptying rates...
December 2016: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/27725383/numerical-evaluation-of-efficacy-of-glutamate-on-gastrointestinal-motility-rapid-mri-study
#19
Shinsuke Nakayama, Hidemi Teramoto
 The umami taste amino acid, glutamate acts as a signaling molecule in multiple cellular systems in the body, including the brain and gastrointestinal tract. Therefore, glutamate may affect appetite by modulating gastrointestinal motility as well as through taste perception. In this study, we examined the effect of glutamate on gastric emptying and duodenal motility, by using rapid magnetic resonance imaging (MRI). Ten healthy male volunteers participated in the measurements. Abdominal coronal MR images were successively acquired after ingestion of a liquid meal with and without monosodium L-glutamate (MSG)...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27678361/effects-of-lizhong-tang-on-gastrointestinal-motility-in-mice
#20
Min Cheol Lee, Wooram Ha, Jinhyeong Park, Junghoon Kim, Yunjin Jung, Byung Joo Kim
AIM: To investigate the effects of Lizhong Tang, a traditional Chinese medicine formula, on gastrointestinal motility in mice. METHODS: The in vivo effects of Lizhong Tang on GI motility were investigated by measuring the intestinal transit rates (ITRs) and gastric emptying (GE) values in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). RESULTS: In normal ICR mice, the ITR and GE values were significantly and dose-dependently increased by Lizhong Tang (ITR values: 54...
September 14, 2016: World Journal of Gastroenterology: WJG
keyword
keyword
40441
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"