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https://www.readbyqxmd.com/read/28526608/microrna-analysis-of-taenia-crassiceps-cysticerci-under-praziquantel-treatment-and-genome-wide-identification-of-taenia-solium-mirnas
#1
Matías Gastón Pérez, Natalia Macchiaroli, Gabriel Lichtenstein, Gabriela Conti, Sebastián Asurmendi, Diego Humberto Milone, Georgina Stegmayer, Laura Kamenetzky, Marcela Cucher, Mara Cecilia Rosenzvit
MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as important regulators of gene expression and perform critical functions in development and disease. In spite of the increased interest in miRNAs from helminth parasites, no information is available on miRNAs from Taenia solium, the causative agent of cysticercosis, a neglected disease affecting millions of people worldwide. Here we performed a comprehensive analysis of miRNAs from Taenia crassiceps, a laboratory model for T. solium studies, and identified miRNAs in the T...
May 17, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28520724/development-of-a-movement-based-in-vitro-screening-assay-for-the-identification-of-new-anti-cestodal-compounds
#2
Dominic Ritler, Reto Rufener, Heinz Sager, Jacques Bouvier, Andrew Hemphill, Britta Lundström-Stadelmann
Intestinal cestodes are infecting millions of people and livestock worldwide, but treatment is mainly based on one drug: praziquantel. The identification of new anti-cestodal compounds is hampered by the lack of suitable screening assays. It is difficult, or even impossible, to evaluate drugs against adult cestodes in vitro due to the fact that these parasites cannot be cultured in microwell plates, and adult and larval stages in most cases represent different organisms in terms of size, morphology, and metabolic requirements...
May 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28513991/immunoprotective-effect-of-chitosan-particles-on-hymenolepis-nana-infected-mice
#3
Mahmoud Abdel-Latif, Gamal El-Shahawi, Shawky M Aboelhadid, Heba Abdel-Tawab
Hymenolepis nana is the most commonly known intestinal cestode infecting mainly human. The present study aimed to investigate the potential effect of chitosan particles (CSP) to enhance the immune system against H. nana infection. Determination of worm burden, egg output, histopathological changes, oxidative stress markers (lipid peroxidation & reduced glutathione), goblet (GCs) and mucosal mast cells (MMCs) counts in intestinal ileum were performed. In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I & II interferons (IFN)-α/ γ, tumor necrosis factor (TNF)-α, mucin 2 (MUC2), and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28501634/helminth-infracommunity-of-the-cane-toad-rhinella-marina-anura-bufonidae-within-its-native-distribution-range
#4
Nallely Ruiz-Torres, Luis García-Prieto, Omar Lagunas-Calvo, Juan Violante-González, David Osorio Sarabia
During August 2010, a total of 66 cane toad Rhinella marina were collected in Laguna de Coyuca, Guerrero, Mexico and examined for the presence of helminths. Ninety-two percent were parasitized by 1 or more parasite species. A total of 4624 individuals were found, belonging to 8 helminth taxa (1 digenean, 1 cestode and 6 nematodes). Infracommunities harbored by this host species are highly variable (mean Jaccard similarity index 0.31±0.27); mean percent similarity index 0.26±0.32) and depauperate (mean richness 1...
May 10, 2017: Parasitology International
https://www.readbyqxmd.com/read/28485262/biological-significance-of-phosphoenolpyruvate-carboxykinase-in-a-cestode-parasite-raillietina-echinobothrida-and-effect-of-phytoestrogens-on-the-enzyme-from-the-parasite-and-its-host-gallus-domesticus
#5
Ramnath, Asim Kumar Dutta, Barilin Dkhar, Veena Tandon, Bidyadhar DAS
Phosphoenolpyruvate carboxykinase (PEPCK) is involved in glycolysis in the cestode parasite, Raillietina echinobothrida; whereas, it executes a gluconeogenic role in its host, Gallus domesticus. Because of its differing primary function in the cestode parasite and its host, this enzyme is regarded as a plausible anthelmintic target. Hence, the biological significance of PEPCK in the parasite was analysed using siRNA against PEPCK from R. echinobothrida (RePEPCK). In order to find out the functional differences between RePEPCK and GdPEPCK (PEPCK from its host, G...
May 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28484564/hydatid-cysts-in-the-right-temporalis-muscle-an-exceptional-clinical-scenario
#6
Sanjeev Attry, Raghavendra Nayak, S K Saha, S N Ghosh
Hydatid diseases is a parasitic infestation of human and herbivorous animals caused by a cestode, Echinococcus granulosus, which resides in the intestine of definitive hosts like dogs and some wild carnivores like foxes. Liver and lung are commonly involved organs and involvement of muscles and bones is very unusual. Hydatid cyst of the temporalis muscle is extremely rare, even in the countries where echinococcal infestation is endemic. We report a case of 23-year-old female patient with a cystic swelling in the right temporalis muscle which turned out to be hydatid cysts...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28450853/micromanagement-of-immune-system-role-of-mirnas-in-helminthic-infections
#7
REVIEW
Naina Arora, Shweta Tripathi, Aloukick K Singh, Prosenjit Mondal, Amit Mishra, Amit Prasad
Helminthic infections fall under neglected tropical diseases, although they inflict severe morbidity to human and causes major economic burden on health care system in many developing countries. There is increased effort to understand their immunopathology in recent days due to their immuno-modulatory capabilities. Immune response is primarily controlled at the transcriptional level, however, microRNA-mediated RNA interference is emerging as important regulatory machinery that works at the translation level...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28435310/tropical-diseases-of-the-myocardium-a-review
#8
REVIEW
Zoe C Groom, Aristotle D Protopapas, Vasileios Zochios
Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28433562/characterization-of-the-complete-mitochondrial-genome-of-khawia-sinensis-belongs-among-platyhelminths-cestodes
#9
Yan Feng, Han-Li Feng, Yi-Hui Fang, Ying-Bing Su
Khawia sinensis is an important species in freshwater fish causing considerable economic losses to the breeding industry. This is the first mt genome of a caryophyllidean cestode characterised. The entire mt genome of K. sinensis is 13,759 bp in length. This mt genome contains 12 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes and two non-coding regions. The arrangement of the K. sinensis mt genome is the same as other tapeworms, however, the incomplete stop codon (A) is more frequent that other species...
April 20, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28426423/the-discovery-of-acanthocephalans-parasitizing-chaetognaths
#10
Horacio Lozano-Cobo, Jaime Gómez-Gutiérrez, Carmen Franco-Gordo, María Del Carmen Gómez Del Prado-Rosas
A comprehensive literature review shows that 12 types of pathogens, micropredators and parasites are reported to interact with chaetognaths, mostly digenean trematodes, cestodes and nematodes larval stages. Through analysis of 78,152 chaetognaths from a monthly zooplankton time series (Jan 1996-Dec 1998) collected in the Mexican Central Pacific twelve acanthocephalan larvae parasitizing chaetognaths were discovered. This is the first record of an acanthocephalan parasitizing chaetognaths, raising to 13 the types of symbionts known to interact with them (excluding predators)...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426422/morphological-re-description-of-electrotaenia-malapteruri-cestoda-proteocephalidae-and-dujardinnascaris-malapteruri-nematoda-heterocheilidae-infecting-the-electric-catfish-malapterurus-electricus-and-heavy-metal-accumulation-in-host-and-parasites-in-relation
#11
Rewaida Abdel-Gaber, Fathy Abdel-Ghaffar, Mohamed Abdallah Shazly, Kareem Morsy, Saleh Al Quraishy, Sanna Mohamed, Heinz Mehlhorn
Parasites are one of the most serious limiting factors in aquaculture. The Electric catfish Malapterurus electricus was subjected to study the prevalence and mean intensity of parasitic infections throughout the whole year of 2015. Heavy metals accumulation in host fish and parasites were determined in relation to water quality and sediments of two different sites of Lake Manzala (Manzala and Bahr El-Baqar), Egypt. A total of 100 specimens of Electric catfish were collected and examined for the presence of helminth parasites...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28420310/helminth-fauna-associated-with-three-neotropical-bat-species-chiroptera-mormoopidae-in-veracruz-mexico
#12
Emilio Clarke-Crespo, Gerardo Pérez-Ponce de León, Salvador Montiel-Ortega, Miguel Rubio-Godoy
Bats are recognized as potential hosts of pathogens exploiting the food chain to reach them as definitive hosts. However, very little is known about their endoparasites, especially for Neotropical bats. In this study, we assessed the helminth fauna associated with 3 insectivorous bat species roosting in the same single hot cave in central Veracruz, Mexico: the ghost-faced bat (Mormoops megalophylla), the naked-backed bat (Pteronotus davyi) and Wagner's mustached bat (Pteronotus personatus). During a period of 1 yr (April 2007-2008), a total of 135 mormoopid bats were collected and examined for helminths...
April 18, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28415922/host-pharmacokinetics-and-drug-accumulation-of-anthelmintics-within-target-helminth-parasites-of-ruminants
#13
A Lifschitz, C Lanusse, L Alvarez
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion (pharmacokinetic phase) directly influence drug concentrations attained at the site of action and the resultant pharmacological effect. The aim of the current review article was to provide an overview of the relationship between the pharmacokinetic features of different anthelmintic drugs, their availability in host tissues, accumulation within target helminths and resulting therapeutic efficacy...
April 26, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28412048/comparative-proteome-profiling-of-hydatid-fluid-from-algerian-patients-reveals-cyst-location-related-variation-in-echinococcus-granulosus
#14
Razika Zeghir-Bouteldja, Andy Polomé, Sabrina Bousbata, Chafia Touil-Boukoffa
Human cystic echinococcosis, an endemic zoonosis in Algeria, is caused by larvae of the cestode Echinococcus granulosus. Parasitic modulation of the immune response allows E. granulosus to persist in intermediate hosts. Previous in vitro and in vivo immunological studies have shown differences in host immune responses according to the status and location of the hydatid cysts in the body. In this study, a proteomic analysis of human hydatid fluids was performed to identify the proteins in hydatid cyst fluids...
April 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28402284/three-new-genera-of-rhinebothriidean-cestodes-from-stingrays-in-southeast-asia
#15
Janine N Caira, Claire J Healy, Fernando P L Marques, Kirsten Jensen
Three genera of rhinebothriideans, previously referred to as New genus 1, New genus 2 and New genus 4, are erected in the the Anthocephaliidae. New genus 1 is established as Divaricobothrium gen. n., with Divaricobothrium tribelum sp. n. as its type species; Echeneibothrium trifidum Shipley et Hornell, 1906 is transferred to the genus as Divaricobothrium trifidum (Shipley et Hornell, 1906) comb. n. This genus is unique among rhinebothriidean genera in bearing bothridia that are posteriorly deeply divided into two lobes with facial loculi but no apical sucker, and a vagina that extends to near the anterior margin of the proglottid...
April 4, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28402281/new-species-of-aberrapex-jensen-2001-cestoda-lecanicephalidea-from-eagle-rays-of-the-genus-myliobatis-cuvier-myliobatiformes-myliobatidae-from-off-argentina
#16
Adriana Menoret, Leonardo Mutti, Veronica A Ivanov
Three new species of Aberrapex Jensen, 2001 (Cestoda: Lecanicephalidea) have been collected from species of Myliobatis Cuvier along the coast of Argentina. Aberrapex ludmilae sp. n. parasitises M. goodei Garman in the San Matías Gulf. This species is unique in a combination of features including the shape and extent of the uterus, scolex size, testis distribution, and by lacking an external seminal vesicle and postovarian vitelline follicles. Aberrapex sanmartini sp. n. from M. goodei in San Blas Bay and A...
April 4, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28398107/first-record-of-raillietina-celebensis-cestoda-cyclophyllidea-in-south-america-redescription-and-phylogeny
#17
Raquel O Simões, Susana B Simões, JoséL Luque, Alena Mayo Iniguez, Arnaldo Maldonado Júnior
Raillietina celebensis is a cestode that parasitizes the small intestine of rats and humans. Here we detail the morphology and morphometry of R. celebenis specimens collected from Rattus norvegicus in the municipality of São Gonçalo, Rio de Janeiro state, Brazil, by light and confocal scanning laser microscopy and also report the results of molecular phylogenetic analyses to determine its relationships within the family Davaineidae. Analysis of the number and size of testes, number and shape of rostellar hooks; cirrus sac length; capsules and eggs per capsule and morphology of the mature proglote allowed concluding that the present specimens constitute a new record of R...
April 11, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28367059/niclosamide-inhibition-of-stat3-synergizes-with-erlotinib-in-human-colon-cancer
#18
Lingyi Shi, Hailun Zheng, Wanle Hu, Bin Zhou, Xuanxuan Dai, Yi Zhang, Zhiguo Liu, Xiaoping Wu, Chengguang Zhao, Guang Liang
Niclosamide, an anthelmintic drug approved by the US Food and Drug Administration against cestodes, is used to treat tapeworm infection. In this study, we show that niclosamide can potentially inhibit signal transducer and activator of transcription 3 (STAT3) in colon cancer cell lines. Combined inhibition of epidermal growth factor receptor and STAT3 by erlotinib and niclosamide synergistically induces apoptosis and antiproliferation in colon cancer cell lines. Our findings suggest that erlotinib and niclosamide combination provides an effective therapeutic approach to improving the prognosis of colon cancer...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28365929/anoplocephala-sp-cestoda-cyclophyllidea-infection-in-horses-in-central-italy
#19
Cristina Roncoron, Antonio Fagiolo, Cristina Amoruso, Claudio De Liberato
Species of Anoplocephalidae are cestodes affecting equines worldwide and causing many intestinal disorders. Between October 2010 and September 2013, 284 faecal samples of horses originating from Lazio Region (Central Italy) were tested for the presence of Anoplocephala sp. eggs by a classic copromicroscopic technique. Data regarding pasture‑dependence/non dependence, age, and sex of the horses were also collected. Statistical analysis, aimed at detecting possible associations between these variables and Anoplocephala sp...
March 31, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28360380/genetic-diversity-of-echinococcus-multilocularis-in-red-foxes-in-poland-the-first-report-of-a-haplotype-of-probable-asian-origin
#20
Jacek Karamon, Krzysztof Stojecki, Malgorzata Samorek-Pierog, Ewa Bilska-Zajac, Miroslaw Rozycki, Ewa Chmurzynska, Jacek Sroka, Jolanta Zdybel, Tomasz Cencek
The aim of the present study was to estimate the genetic diversity of the cestode Echinococcus multilocularis Leuckart, 1863 in Poland based on sequence analysis of the mitochondrial genes of worms isolated from red foxes, Vulpes vulpes (Linnaeus). Overall, 83 adults of E. multilocularis from the same number of foxes in different parts of Poland were used for analysis. Sequences of the three mitochondrial genes, cytochrome b (cob), NADH dehydrogenase subunit 2 (nad2) and cytochrome c oxidase subunit 1 (cox1), were analysed...
March 9, 2017: Folia Parasitologica
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