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https://www.readbyqxmd.com/read/29138933/population-based-screening-improves-histopathological-prognostic-factors-in-colorectal-cancer
#1
Mónica Mengual-Ballester, Enrique Pellicer-Franco, Graciela Valero-Navarro, Victoriano Soria-Aledo, José Andrés García-Marín, José Luis Aguayo-Albasini
INTRODUCTION: Diagnosis of colorectal cancer (CRC) based on clinical symptoms is usually established in its advanced stages. One strategy for reducing mortality is the early detection and removal of preneoplastic and initial neoplastic lesions, even before the first symptoms appear, by means of population-based screening campaigns. The aim of the present study is to determine whether CRC diagnosed via a screening campaign has more favourable histopathological prognostic factors than when diagnosed in the symptomatic phase...
November 14, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29133254/characteristics-and-progression-of-preclinical-inflammatory-bowel-disease
#2
Iago Rodríguez-Lago, Olga Merino, Irene Azagra, Ainara Maiz, Eva Zapata, Rebeca Higuera, Isabel Montalvo, María Fernández-Calderón, Paz Arreba, Juan Carrascosa, Ainara Iriarte, Isabel Portillo, Urko Aguirre, Manuel Barreiro-de Acosta, Miguel Muñoz-Navas, José Luis Cabriada
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a chronic disease usually diagnosed after the appearance of gastrointestinal symptoms. Little is known about IBD progression during its early and even preclinical phases. We aimed to determine the number of new incidental diagnoses of IBD in an older population, and evaluate disease progression from its early stages. METHODS: We performed a retrospective analysis of 31,005 colonoscopies performed during colorectal cancer screening of patients with positive results from fecal immunochemical tests, at 11 centers in the Basque Country (Spain) from 2009 through 2014...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29132333/oestrogen-receptor-beta-isoform-expression-in-sporadic-colorectal-cancer-familial-adenomatous-polyposis-and-progressive-stages-of-colorectal-cancer
#3
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. METHODS: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29131639/proteomic-characterization-of-transcription-and-splicing-factors-associated-with-a-metastatic-phenotype-in-colorectal-cancer
#4
Sofia Torres, Irene Garcia-Palmero, Consolación Marin-Vicente, Ruben A Bartolome, Eva Calviño, María Jesús Fernandez-Aceñero, J Ignacio Casal
We investigated new transcription and splicing factors associated with the metastatic phenotype in colorectal cancer. A concatenated tandem array of consensus transcription factors (TFs)-response elements was used to pull down nuclear extracts in two different pairs of colorectal cancer cells, KM12SM/KM12C and SW620/480, genetically-related but differing in metastatic ability. Proteins were analyzed by label-free LC-MS and quantified with MaxLFQ. We found 240 proteins showing a significant dysregulation in highly-metastatic KM12SM cells relative to non-metastatic KM12C cells and 257 proteins in metastatic SW620 versus SW480...
November 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29129340/synchronous-colorectal-cancer-and-multiple-myeloma-with-chest-wall-involvement-is-this-a-coincidence
#5
Qiu-Li Li, Jin-An Ma, Hai-Peng Li, Ren-Bing Huang, Chun-Hong Hu, Xian-Ling Liu, Ya-Wen Gao, Gang-Hua Feng, Fang Wu
Multiple primary malignant neoplasms (MPMNs) are rare malignant neoplasms that simultaneously or successively occur in the same patient as 2 or more primary malignancies. Currently, an increasing number of cases are being reported. In general, MPMNs more commonly occur as 2 solid tumors or 2 hematological malignancies. Cases of MPMN that involve a solid tumor and a hematological malignancy are rare. Here, we report a case of synchronous colorectal cancer (CRC) and multiple myeloma (MM) with chest wall involvement...
September 25, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/29125801/laparoscopic-versus-open-restorative-proctocolectomy-for-familial-adenomatous-polyposis
#6
Fábio Guilherme Campos, Carlos Augusto Real Martinez, Mariane Gouveia Monteiro de Camargo, Daniele Menezes Cesconetto, Sérgio Carlos Nahas, Ivan Cecconello
PURPOSE: This study compared outcomes after laparoscopic (LAP) or conventional (open) total proctocolectomy with outcomes after ileal J-pouch anal anastomosis (IPAA) at a single institution. METHODS: Charts from 133 familial adenomatous polyposis patients (1997-2013) were reviewed. Demographic data (age, sex, color, American Society of Anesthesiologists [ASA] status, previous surgery, and body mass index) and surgical outcomes (length of stay, early and late morbidity, reoperation, and mortality rates) were compared among 63 patients undergoing IPAA...
November 10, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29124284/ca-2-nuclear-factor-of-activated-t-cells-signaling-is-enriched-in-early-onset-rectal-tumors-devoid-of-canonical-wnt-activation
#7
Raju Kumar, Ratheesh Raman, Viswakalyan Kotapalli, Swarnalata Gowrishankar, Saumyadipta Pyne, Jonathan R Pollack, Murali D Bashyam
Our previous extensive analysis revealed a significant proportion of early-onset colorectal tumors from India to be localized to the rectum in younger individuals and devoid of deregulated Wnt/β-catenin signaling. In the current study, we performed a comprehensive genome-wide analysis of clinically well-annotated microsatellite stable early-onset sporadic rectal cancer (EOSRC) samples. Results revealed extensive DNA copy number alterations in rectal tumors in the absence of deregulated Wnt/β-catenin signaling...
November 9, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29123962/distinctive-features-of-tumor-infiltrating-%C3%AE-%C3%AE-t-lymphocytes-in-human-colorectal-cancer
#8
S Meraviglia, E Lo Presti, M Tosolini, C La Mendola, V Orlando, M Todaro, V Catalano, G Stassi, G Cicero, S Vieni, J J Fourniè, F Dieli
γδ T cells usually infiltrate many different types of cancer, but it is unclear whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating γδ T cells and those in the corresponding normal tissue remain largely unknown. Here we have studied features of γδ T cells in colorectal cancer, normal colon tissue and peripheral blood, and correlated their levels with clinicopathologic hallmarks. Flow cytometry and transcriptome analyses showed that the tumor comprised a highly variable rate of TILs (5-90%) and 4% γδ T cells on average, with the majority expressing Vδ1...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29121143/mismatch-repair-deficiency-testing-in-patients-with-colorectal-cancer-and-nonadherence-to-testing-guidelines-in-young-adults
#9
Talha Shaikh, Elizabeth A Handorf, Joshua E Meyer, Michael J Hall, Nestor F Esnaola
Importance: Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults (age, <50 years) with CRC. Mismatch repair deficiency can be due to germline mutations or epigenetic inactivation, affects prognosis and response to systemic therapy, and results in unrepaired repetitive DNA sequences, which increases the risk of multiple malignant tumors...
November 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29116438/staging-with-computed-tomography-of-patients-with-colon-cancer
#10
M L Malmstrøm, S Brisling, T W Klausen, A Săftoiu, T Perner, P Vilmann, I Gögenur
PURPOSE: Accurate staging of colonic cancer is important for patient stratification. We aimed to correlate the diagnostic accuracy of preoperative computed tomography (CT) with final histopathology as reference standard. METHODS: Data was collected retrospectively on 615 consecutive patients operated for colonic cancer. Evaluation was based upon T-stage. Patients were stratified into high-risk and low-risk groups, based on the extent of tumor invasion beyond the proper muscle layer of more or less than 5 mm...
November 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29116061/-exosomal-surface-protein-markers-in-diagnosis-of-colorectal-cancer
#11
E N Savvateeva, A A Tikhonov, V I Butvilovskaya, M V Tsybulskaya, A Yu Rubina
Colorectal cancer (CRC) is one of the most common primary malignancies. Early stages of the disease are asymptomatic in the majority of cases, leading to late detection and high mortality. Available noninvasive diagnostic techniques are limited in sensitivity and specificity, and designing new ones is still a pressing problem. Exosomes are membrane-derived microvesicles secreted into human biological fluids and provide a novel way to assess the course of an oncology disease. The review describes the repertoire of exosomal surface biomarkers found in the blood of CRC patients and the prospects of employing multiplexed tests for exosomal markers in early noninvasive diagnosis of cancer...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29113658/circulating-cell-free-dna-in-plasma-of-colorectal-cancer-patients-a-potential-biomarker-for-tumor-burden
#12
Jagdeep Singh Bhangu, Hossein Taghizadeh, Tamara Braunschmid, Thomas Bachleitner-Hofmann, Christine Mannhalter
BACKGROUND: Measurement of cell-free DNA (cfDNA) in plasma - the so called liquid biopsy - is a novel method for early detection of cancer. Necrotic cancer cells release various DNA fragments that can be detected in plasma or serum. The aim of our study was to investigate the concentration of circulating ALU115, LINE79 and LINE297 fragments in plasma from venous and arterial blood of colorectal cancer (CRC) patients before, during and 5 days after surgical intervention. PATIENTS AND METHODS: Thirty patients (16 female, 14 male, median age 56 years), undergoing surgery for colorectal and appendix cancer, and 17 healthy volunteers were included in this study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112994/risk-of-recurrence-after-endoscopic-resection-of-early-colorectal-cancer-with-positive-margins
#13
Je-Wook Shin, Kyung Su Han, Jong Hee Hyun, Sang Jae Lee, Bun Kim, Chang Won Hong, Byung Chang Kim, Dae Kyung Sohn, Hee Jin Chang, Min Jung Kim, Sung Chan Park, Jae Hwan Oh
Background and study aim Additional surgery is recommended if an endoscopically resected T1 colorectal cancer (CRC) specimen shows a positive resection margin. We aimed to investigate the significance of a positive resection margin in endoscopically resected T1 CRC. Patients and methods We enrolled 265 patients with T1 CRC who underwent endoscopic resection between January 2001 and December 2016. The inclusion criteria were: 1) complete resection by endoscopy, and 2) pathology of a positive margin. Among the 265 patients, 213 underwent additional surgery and 52 did not...
November 7, 2017: Endoscopy
https://www.readbyqxmd.com/read/29112225/global-and-targeted-circulating-microrna-profiling-of-colorectal-adenoma-and-colorectal-cancer
#14
Jinhua Zhang, Gottumakkala S Raju, David W Chang, Shu-Hong Lin, Zhinan Chen, Xifeng Wu
BACKGROUND: Circulating microRNAs (miRNAs) are emerging as promising biomarkers for cancer. The objective of the current study was to investigate the potential of circulating cell-free miRNAs as biomarkers for colorectal cancer (CRC) and its precursor lesion, colorectal adenoma. METHODS: The serum levels of 800 miRNAs were assessed in a discovery set of 21 patients with CRC, 19 patients with adenoma, and 21 healthy controls using the NanoString miRNA analysis platform...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29111094/real-time-pcr-based-method-for-the-rapid-detection-of-extended-ras-mutations-using-bridged-nucleic-acids-in-colorectal-cancer
#15
Takao Iida, Yukie Mizuno, Yasuharu Kaizaki
Mutations in RAS and BRAF are predictors of the efficacy of anti-epidermal growth factor receptor (EGFR) therapy in patients with metastatic colorectal cancer (mCRC). Therefore, simple, rapid, cost-effective methods to detect these mutations in the clinical setting are greatly needed. In the present study, we evaluated BNA Real-time PCR Mutation Detection Kit Extended RAS (BNA Real-time PCR), a real-time PCR method that uses bridged nucleic acid clamping technology to rapidly detect mutations in RAS exons 2-4 and BRAF exon 15...
October 27, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29110090/assessing-the-economic-advantage-of-laparoscopic-vs-open-approaches-for-colorectal-cancer-by-a-propensity-score-matching-analysis
#16
Hiromitsu Hayashi, Nobuyuki Ozaki, Katsuhiro Ogawa, Yoshiaki Ikuta, Hideyuki Tanaka, Kenichi Ogata, Koichi Doi, Hiroshi Takamori
PURPOSES: This study investigated the surgical outcomes and potential economic advantage of open vs. laparoscopic surgery for colorectal cancer using a propensity score matching analysis. METHODS: We examined the surgical and economic outcomes of patients undergoing laparoscopic (N = 127) and open surgery (N = 253) for colorectal cancer and then compared these outcomes in two groups (N = 103 each) using a propensity score matching analysis. RESULTS: Compared to open surgery, the laparoscopic approach was associated with a significantly lower overall morbidity rate (14 vs...
November 7, 2017: Surgery Today
https://www.readbyqxmd.com/read/29104470/critical-role-of-p53-and-k-ras-in-the-diagnosis-of-early-colorectal-cancer-a-one-year-single-center-analysis
#17
Hui-Ying Lu, Ri-Tian Lin, Guang-Xi Zhou, Tian-Ming Yu, Zhan-Ju Liu
Background: Colorectal cancer (CRC) is strongly associated with colorectal polyps, which has become the third most common cancer in China. In the present study, we revealed the susceptible population and risk factors of colorectal polyps, and analyzed the expression of Ki-67, p53 and K-ras in the intestinal mucosa of patients with colorectal polyps in order to explore their significance in the detection and prognosis of CRC at an early stage. Materials and Methods: Total 801 cases of colorectal polyps were collected during endoscopic resection including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29104111/clinical-and-biological-significance-of-mir-193a-3p-targeted-kras-in-colorectal-cancer-pathogenesis
#18
Afraa Mamoori, Riajul Wahab, Farhadul Islam, Katherine Lee, Jelena Vider, Cu-Tai Lu, Vinod Gopalan, Alfred King-Yin Lam
This study was to investigate the expression pattern, mechanisms and clinicopathological implications of miR-193a-3p in colorectal cancer. Fresh frozen tissues from 70 matched colorectal adenocarciomas and the adjacent non-neoplastic mucosae were prospectively collected. Two colorectal cancer cell lines (SW480 and SW48) and a non-neoplastic colon cell line (FHC) were also used. The expression levels of miR193a-3p in the cells and tissues were measured by quantitative real-time polymerase chain reaction. The expression of KRAS protein as a predicted downstream target for miR-193a was studied by immunohistochemistry...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29101736/clinical-implications-of-nras-overexpression-in-resectable-pancreatic-adenocarcinoma-patients
#19
Javier Martinez-Useros, Weiyao Li, Tihomir Georgiev-Hristov, Maria J Fernandez-Aceñero, Aurea Borrero-Palacios, Nuria Perez, Angel Celdran, Jesus Garcia-Foncillas
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer, and its incidence is rising worldwide. Although survival can be improved by surgical resection, when detected at an early stage, this type of cancer is usually asymptomatic, and disease becomes only apparent after metastasis. Adjuvant treatment does not improve survival, thus after surgery there is a lack of predictive and prognosis biomarkers to predict treatment response and survival. The mitogen-activated protein-kinase and phosphoinositide 3-kinase signalling pathways play a crucial role in cancer development and progression...
November 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29101452/compliance-with-the-62-day-target-does-not-improve-long-term-survival
#20
Ronak Patel, John E Anderson, Claire McKenzie, Mhairi Simpson, Nina Singh, Fredrick Ruzvidzo, Praveen Sharma, Roy Scott, Angus MacDonald
AIMS: Scottish Intercollegiate Guidelines Network (SIGN) guidelines require patients with colorectal cancer to wait no longer than 62 days from first referral to initiation of definitive treatment. We previously demonstrated that failure to meet with these guidelines did not appear to lead to poor outcomes in the short term. This study investigates whether this holds true over a longer period. METHODS: The survival status of 1,012 patients treated for colorectal cancer between January 1999 and June 2005 was reviewed...
November 3, 2017: International Journal of Colorectal Disease
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