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https://www.readbyqxmd.com/read/28922695/strategies-for-detecting-colon-cancer-in-patients-with-inflammatory-bowel-disease
#1
REVIEW
William A Bye, Tran M Nguyen, Claire E Parker, Vipul Jairath, James E East
BACKGROUND: Patients with longstanding ulcerative colitis and colonic Crohn's disease have an increased risk of colorectal cancer (CRC) compared with the general population. This review assessed the evidence that endoscopic surveillance may prolong life by allowing earlier detection of CRC or its pre-cursor lesion, dysplasia, in patients with inflammatory bowel disease (IBD). OBJECTIVES: To assess the effectiveness of cancer surveillance programs for diagnosis of IBD-associated colorectal cancer and in reducing the mortality rate from colorectal cancer in patients with IBD...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922388/expression-and-prognosis-analyses-of-the-tob-btg-antiproliferative-apro-protein-family-in-human-cancers
#2
Yuru Bai, Lu Qiao, Ning Xie, Yongquan Shi, Na Liu, Jinhai Wang
BACKGROUND: Despite advances in early diagnosis and treatment, cancer remains the major cause of mortality in the world. The Tob/BTG antiproliferative (APRO) protein family is reported to participate in diverse human diseases. However, there's little known about their expression and prognostic values in most human cancers. METHODS: We performed a detailed cancer vs. normal analysis. The mRNA expression levels of APRO family in various cancers were analyzed via the Oncomine database...
2017: PloS One
https://www.readbyqxmd.com/read/28918433/procalcitonin-and-c-reactive-protein-as-early-markers-of-postoperative-intra-abdominal-infection-in-patients-operated-on-colorectal-cancer
#3
E Domínguez-Comesaña, S M Estevez-Fernández, V López-Gómez, J Ballinas-Miranda, R Domínguez-Fernández
PURPOSE: The aim of this study was to evaluate the accuracy of serum procalcitonin (PCT) and C-reactive protein (CRP) for early diagnosis of postoperative intra-abdominal infections (PIAI) after elective surgery for colorectal cancer. METHODS: Prospective observational study including patients operated on for colorectal cancer between January and December of 2015 was performed. Serum PCT and CRP levels were measured before surgery and daily until postoperative day 3...
September 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28917347/optical-diagnosis-of-early-colorectal-cancer-riding-the-highs%C3%A2-and-lows-of-the-japanese-narrow-band-imaging-expert%C3%A2-team-classification
#4
EDITORIAL
Sarah K McGill, Roy Soetikno, Tonya Kaltenbach
No abstract text is available yet for this article.
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28917272/towards-personalized-medicine-of-colorectal-cancer
#5
REVIEW
Mohammad Azhar Aziz, Zeyad Yousef, Ayman M Saleh, Sameer Mohammad, Bandar Al Knawy
Efforts in colorectal cancer (CRC) research aim to improve early detection and treatment for metastatic stages which could translate into better prognosis of this disease. One of the major challenges that hinder these efforts is the heterogeneous nature of CRC and involvement of diverse molecular pathways. New large-scale 'omics' technologies are making it possible to generate, analyze and interpret biological data from molecular determinants of CRC. The developments of sophisticated computational analyses would allow information from different omics platforms to be integrated, thus providing new insights into the biology of CRC...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28915524/risk-of-colorectal-cancer-after-a-negative-colonoscopy-in-low-to-moderate-risk-individuals-impact-of-a-10-year-colonoscopy
#6
Sanjay K Murthy, Catherine Dubé, Alaa Rostom, Eric I Benchimol, Robin Ducharme, Rinku Sutradhar, Linda Rabeneck, Lawrence Paszat, Jill Tinmouth
Background and study aims National societies recommend colorectal cancer (CRC) screening 10 years after a normal ("negative") colonoscopy in low-risk individuals. We studied the impact of a 10-year repeat colonoscopy on the risk of early incident CRC. Patients and methods We used health administrative data from Ontario, Canada, to conduct a population-based retrospective cohort study in 50 - 74-year-old individuals at low-to-moderate risk of CRC who had a negative colonoscopy between 1996 and 2001. We approximated exposure to repeat colonoscopy using an 8 - 12-year window...
September 15, 2017: Endoscopy
https://www.readbyqxmd.com/read/28912140/down-regulation-of-safb-sustains-the-nf-%C3%AE%C2%BAb-pathway-by-targeting-tak1-during-the-progression-of-colorectal-cancer
#7
Hong-Li Jiao, Ya-Ping Ye, Run-Wei Yang, Hui-Ying Sun, Shu-Yang Wang, Yong-Xia Wang, Zhi-Yuan Xiao, Liu-Qing He, Juan-Juan Cai, Wen-Ting Wei, Yan-Ru Chen, Chun-Cai Gu, Yue-Long Cai, Yun-Teng Hu, Qiu-Hua Lai, Jun-Feng Qiu, Li Liang, Guangwen Cao, Wen-Ting Liao, Yanqing Ding
PURPOSE: To investigate the role and the underlying mechanism of scaffold attachment factor B (SAFB) in the progression of colorectal cancer (CRC). EXPERIMENTAL DESIGN: SAFB expression was analyzed in the Cancer Outlier Profile Analysis of Oncomine and in 175 paraffin-embedded archived CRC tissues. Gene Ontology analyses were performed to explore the mechanism of SAFB in CRC progression. Western blot, RT-PCR, luciferase assay and chromatin immunoprecipitation (ChIP) were used to detect the regulation of transforming growth factor-β-activated kinase 1 (TAK1) and NF-κB signaling by SAFB...
September 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28912018/association-between-germline-mutations-in-brf1-a-subunit-of-the-rna-polymerase-iii-transcription-complex-and-hereditary-colorectal-cancer
#8
Fernando Bellido, Nadine Sowada, Pilar Mur, Conxi Lázaro, Tirso Pons, Rafael Valdés-Mas, Marta Pineda, Gemma Aiza, Silvia Iglesias, José Luís Soto, Miguel Urioste, Trinidad Caldés, Milagros Balbín, Pilar Blay, Daniel Rueda, Mercedes Durán, Alfonso Valencia, Victor Moreno, Joan Brunet, Ignacio Blanco, Matilde Navarro, George A Calin, Guntram Borck, Xose S Puente, Gabriel Capellá, Laura Valle
BACKGROUND & AIMS: Although there is a genetic predisposition to colorectal cancer (CRC), few of the genes that affect risk have been identified. We performed whole-exome sequence analysis of individuals in a high-risk family without mutations in genes previously associated with CRC risk to identify variants associated with inherited CRC. METHODS: We collected blood samples from 3 relatives with CRC in Spain (65, 62 and 40 years old at diagnosis) and perfomed whole-exome sequence analyses...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28906258/early-tumor-shrinkage-indicates-a-favorable-response-to-bevacizumab-based-first-line-chemotherapy-for-metastatic-colorectal-cancer
#9
Mamoru Ito, Hitoshi Kusaba, Satomi Mukaide, Junji Kishimoto, Hozumi Shimokawa, Shingo Tamura, Akitaka Makiyama, Gen Hirano, Hisanobu Oda, Tsuyoshi Shirakawa, Masato Komoda, Keita Uchino, Risa Tanaka, Kenji Mitsugi, Taito Esaki, Shuji Arita, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
A close correlation between early tumor shrinkage (ETS) and overall survival (OS) has been shown in antiepidermal growth factor receptor antibody-based chemotherapies for metastatic colorectal cancer (mCRC), but the clinical impact of ETS in bevacizumab-based chemotherapy has not been adequately clarified. Clinical data of mCRC patients who started initial chemotherapy without antiepidermal growth factor receptor antibody from 2005 to 2010 were retrospectively evaluated. The relative change in tumor size after 8 weeks of chemotherapy expected from the first image assessment [estimated ETS (EETS)] and the relative change in the tumor size at the nadir compared with the baseline [depth of response (DPR)] were examined...
September 12, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28905105/diagnostic-and-prognostic-role-of-18-fdg-pet-ct-in-the-management-of-resectable-biliary-tract-cancer
#10
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Wan Hang Chiu, Chung Mau Lo
OBJECTIVES: Role of 18-FDG PET/CT had been well established in other more prevalent malignancies such as colorectal and lung cancer; however, this is not as well defined in cholangiocarcinoma. Literature focusing on the prognostic values of preoperative PET/CT for resectable cholangiocarcinoma is scarce. METHOD: This is a retrospective cohort of 66 consecutive patients who had received curative resection for cholangiocarcinoma from 2010 to 2015. All patients had preoperative 18-FDG PET/CT performed...
September 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28903413/a-novel-heterozygous-germline-deletion-in-msh2-gene-in-a-five-generation-chinese-family-with-lynch-syndrome
#11
Bin Wu, Wuyang Ji, Shengran Liang, Chao Ling, Yan You, Lai Xu, Min-Er Zhong, Yi Xiao, Hui-Zhong Qiu, Jun-Yang Lu, Santasree Banerjee
Lynch syndrome (LS) is one of the most common familial forms of colorectal cancer predisposing syndrome with an autosomal dominant mode of inheritance. LS is caused by the germline mutations in DNA mismatch repair (MMR) genes including MSH2, MLH1, MSH6 and PMS2. Clinically, LS is characterized by high incidence of early-onset colorectal cancer as well as endometrial, small intestinal and urinary tract cancers, usually occur in the third to fourth decade of the life. Here we describe a five generation Chinese family with LS clinically diagnosed according to the Amsterdam II criteria...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901001/-early-versus-traditional-postoperative-oral-feeding-in-patients-undergoing-elective-colorectal-surgery-a-meta-analysis-of-safety-and-efficacy
#12
Kun Zhang, Sirong Cheng, Qi Zhu, Zhenguo Han
OBJECTIVE: To compare the outcomes of early oral feeding (EOF) and the traditional oral feeding (TOF) in postoperative patients with colorectal cancer using Meta-analysis. METHODS: The databases of PubMed, SCI, Ovid, The Cochrane Library, CNKI, CBM, VIP and Wanfang Data were searched to collect randomized controlled trial (RCT) about EOF versus TOF in patients undergoing elective colorectal surgery. The retrieval time span was from inception to June 1, 2016. The studies were screened according to the inclusion and exclusion criteria...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28901000/-diagnostic-value-of-dynamic-monitoring-of-c-reactive-protein-in-drain-drainage-to-predict-early-anastomotic-leakage-after-colorectal-cancer-surgery
#13
Jia Lu, Lei Zheng, Runtian Li, Chunmin Hao, Wenbin Gao, Ziwei Feng, Guangya Yin, Yue Wang
OBJECTIVE: To evaluate the diagnostic value of dynamic monitoring of C-reactive protein (CRP) in drainage fluid in predicting early anastomotic leakage after colorectal surgery. METHODS: This study enrolled 172 patients, who were diagnosed as colorectal cancer before operation and underwent radical surgery, without residual tumor tissues by postoperative pathology and perioperative infection, at the Tianjin Medical University Cancer Hospital between July 2015 and January 2016...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28895353/-circulating-long-noncoding-rnas-as-biomarkers-in-tumor-diagnosis
#14
Nan Jiang, Haihua Tian, Jinchang Pan, Zhaohui Gong
Long noncoding RNAs (lncRNAs) are involved in vital life processes of gene expression, epigenetic regulation and X-chromosome inactivation. lncRNAs are also closely associated with tumor initiation and progression. Moreover, lncRNAs may enter human circulation system in the form of microvesicle or exosome, or in combination with RNA binding protein. Interestingly, the circulating lncRNAs are widely existed in body fluids, such as blood and urine. We review the origin of circulating lncRNAs, and the detection methods as potential biomarkers...
June 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28894518/assessment-of-bone-morphogenetic-protein-3-methylation-in-iranian-patients-with-colorectal-cancer
#15
Massoud Houshmand, Mohammad Reza Abbaszadegan, Mohammad Amin Kerachian
BACKGROUND Colorectal cancer (CRC) is a common cancer that results in outstanding morbidity and mortality worldwide. DNA methylation is one of the most important epigenetic events that is thought to occur during the early stages of oncogenic transformation especially in CRC. The aim of this study was to investigate whether hypermethylation of bone morphogenetic protein 3 (BMP3) in tissue samples is implicated in Iranian patients with CRC. METHODS From fresh frozen tissue samples of 30 patients with CRC, the DNA was isolated, treated with sodium bisulfite and analyzed by methylation-specific polymerase chain reaction with primers specific for methylated or unmethylated promoter sequences of the BMP3 gene...
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28890131/characterization-of-systemic-neutrophil-function-in-patients-undergoing-colorectal-cancer-resection
#16
Jonathan J R Richardson, Charles Hendrickse, Fang Gao-Smith, David R Thickett
BACKGROUND: In patients with colorectal cancer, the generation and maintenance of a systemic inflammatory response is associated with poor outcomes. Neutrophils have been implicated in the prognosis of such patients, but little is known about their functional response to surgery. This study was conducted to characterize neutrophil function of patients undergoing colorectal cancer resection. MATERIALS AND METHODS: Systemic neutrophils were isolated from patients with colorectal cancer who underwent surgical resection preoperatively (day 0) and postoperatively (day 1 and day 3)...
September 7, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28887525/mier3-suppresses-colorectal-cancer-progression-by-down-regulating-sp1-inhibiting-epithelial-mesenchymal-transition
#17
Man Peng, Yukun Hu, Wen Song, Shiyu Duan, Qiong Xu, Yanqing Ding, Jian Geng, Jun Zhou
Mesoderm induction early response 1, family member 3 (MIER3) has recently been identified as a potential cancer susceptibility gene. However, the expression pattern and the role of MIER3 in the progression of colorectal cancer (CRC) have not yet been well characterized. Here, we reported that MIER3 was significantly reduced in human primary colorectal cancer and was associated with CRC metastasis and poor prognosis. Moreover, the up-regulation of MIER3 expression significantly inhibited CRC cell proliferation, migration and invasion in vitro and repressed tumor growth and metastasis in vivo...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886423/molecular-imaging-of-colorectal-tumors-by-targeting-colon-cancer-secreted-protein-2-ccsp-2
#18
Jaeil Kim, Eun-Ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanford D Markowitz, Sang-Yeob Kim, Seung-Jae Myung
A versatile biomarker for detecting colonic adenoma and colon cancer has yet to be developed. Colon cancer secreted protein-2 (CCSP-2) is a protein specifically expressed and secreted in colon adenomas and cancers. We developed a fluorescent imaging method based on CCSP-2 targeting for a more sensitive and specific detection of colorectal tumors. CCSP-2 expression was evaluated in human colon adenoma and colorectal specimens. Anti-CCSP-2 antibody was labeled with a near-infrared fluorescent dye, FPR-675, and molecular imaging of surgical human colorectal tumors was performed...
September 4, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28885865/changes-in-insurance-coverage-and-stage-at-diagnosis-among-nonelderly-patients-with-cancer-after-the-affordable-care-act
#19
Ahmedin Jemal, Chun Chieh Lin, Amy J Davidoff, Xuesong Han
Purpose To examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with newly diagnosed cancer after the Affordable Care Act (ACA). Patients and Methods By using the National Cancer Data Base, we estimated absolute change (APC) and relative change in percent uninsured among patients with newly diagnosed cancer age 18 to 64 years between 2011 to the third quarter of 2013 (pre-ACA implementation) and the second to fourth quarter of 2014 (post-ACA) in Medicaid expansion and nonexpansion states by family income level...
September 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28884417/neratinib-first-global-approval
#20
Emma D Deeks
Neratinib (Nerlynx™) is an oral, irreversible inhibitor of the human epidermal growth factor receptors HER1 (EGFR), HER2 and HER4. The drug originally arose from research by Wyeth (now Pfizer) and is now being developed by Puma Biotechnology primarily for the treatment of HER2-positive (HER+) breast cancer. Neratinib is approved in the USA for the extended adjuvant treatment of patients with HER2+ early-stage breast cancer who have been previously treated with a trastuzumab-based adjuvant regimen, and is in the preregistration phase for this indication in the EU...
September 7, 2017: Drugs
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