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RANDOMIZED CONTROLLED TRIAL
N L Messina, M Wang, E K Forbes, B Freyne, W P Hasang, S Germano, R Bonnici, F Summons, K Gardiner, S Donath, R Gordon, S J Rogerson, N Curtis
BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccination has off-target protective effects against infections unrelated to tuberculosis. Among these, murine and human studies suggest that BCG vaccination may protect against malaria. We investigated whether BCG vaccination influences neonatal in vitro cytokine responses to Plasmodium falciparum. Blood samples were collected from 108 participants in the Melbourne Infant Study BCG for Allergy and Infection Reduction (MIS BAIR) randomised controlled trial (Clinical trials registration NCT01906853, registered July 2013), seven days after randomisation to neonatal BCG (n = 66) or no BCG vaccination (BCG-naïve, n = 42)...
April 30, 2024: BMC Immunology
#22
JOURNAL ARTICLE
Loick Pradel Kojom Foko, Carole Else Eboumbou Moukoko, Jahnvi Jakhan, Geetika Narang, Joseph Hawadak, Francine Dorgelesse Kouemo Motse, Veena Pande, Vineeta Singh
The bulk of malaria rapid diagnostic tests (RDTs) target histidine-rich protein 2 of Plasmodium falciparum, the deadliest malaria species. The WHO considers pfhrp2/3 deletions as one of the main threats to successful malaria control and/or elimination; as such, parasites that lack part or all of the pfhrp2 gene are missed by pfHRP2-targeting RDTs. Such deletions have been reported in several African and Asian countries, but little is known in Cameroon and India. Blood samples were collected from individuals living in four areas of Cameroon (Douala, Maroua, Mayo-Oulo, Pette) and India (Mewat, Raipur, Ranchi, Rourkela)...
April 30, 2024: American Journal of Tropical Medicine and Hygiene
#23
JOURNAL ARTICLE
Kanika Devi, Anshuman Chandra, Virender Kumar, Jithesh Othayoth, Brijesh Rathi, Vijay Kumar Goel
The presence of drug-resistant variants of Plasmodium parasites within the population has presented a substantial obstacle to the eradication of Malaria. As a result, numerous research groups have directed their efforts towards creating new medication candidates that specifically target parasites. In this study, our main objective was to identify tri-peptide inhibitors for Plasmodium falciparum Dihydrofolate Reductase ( Pf DHFR) with the aim of finding a new peptide that exhibits superior binding properties compared to the current inhibitor, WR99210...
April 30, 2024: Journal of Biomolecular Structure & Dynamics
#24
EDITORIAL
Jin-Hee Han, Feng Lu, Yang Cheng, Md Atique Ahmed
No abstract text is available yet for this article.
2024: Frontiers in Cellular and Infection Microbiology
#25
JOURNAL ARTICLE
Nicholas Ekow Thomford, Tracy Kellermann, Robert Peter Biney, Charné Dixon, Samuel Badu Nyarko, Richmond Owusu Ateko, Martins Ekor, George B Kyei
BACKGROUND: Despite efforts made to reduce morbidity and mortality associated with malaria, especially in sub-Saharan Africa, malaria continues to be a public health concern that requires innovative efforts to reach the WHO-set zero malaria agenda. Among the innovations is the use of artemisinin-based combination therapy (ACT) that is effective against Plasmodium falciparum. Generic artemether-lumefantrine (AL) is used to treat uncomplicated malaria after appropriate diagnosis. AL is metabolized by the cytochrome P450 family of enzymes, such as CYP2B6, CYP3A4 and CYP3A5, which can be under pharmacogenetic influence...
April 29, 2024: Malaria Journal
#26
JOURNAL ARTICLE
Haider Abbas, Muhammad S Sajid, Hafiz M Rizwan, Urfa B Tahir, Shahid H Farooqi, Zeeshan Iqbal, Muhammad A Malik, Kashaf Yaseen, Mahvish Maqbool, Faiz A Raza, Mohsin Raza, Dalia Fouad, Farid S Ataya
The Plasmodium is responsible for malaria which poses a major health threat, globally. This study is based on the estimation of the relative abundance of mosquitoes, and finding out the correlations of meteorological parameters (temperature, humidity and rainfall) with the abundance of mosquitoes. In addition, this study also focused on the use of nested PCR (species-specific nucleotide sequences of 18S rRNA genes) to explore the Plasmodium spp. in female Anopheles. In the current study, the percentage relative abundance of Culex mosquitoes was 57...
April 30, 2024: Scientific Reports
#27
JOURNAL ARTICLE
Profile of metacaspase gene expression in Plasmodium vivax field isolates from the Brazilian Amazon.
Carolina Moreira Blanco, Hugo Amorim Dos Santos de Souza, Priscilla da Costa Martins, Camila Fabbri, Fernanda Souza de Souza, Josué da Costa Lima-Junior, Stefanie Costa Pinto Lopes, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Paulo Renato Rivas Totino
BACKGROUND: Metacaspases comprise a family of cysteine proteases implicated in both cell death and cell differentiation of protists that has been considered a potential drug target for protozoan parasites. However, the biology of metacaspases in Plasmodium vivax - the second most prevalent and most widespread human malaria parasite worldwide, whose occurrence of chemoresistance has been reported in many endemic countries, remains largely unexplored. Therefore, the present study aimed to address, for the first time, the expression pattern of metacaspases in P...
April 29, 2024: Molecular Biology Reports
#28
Valeri Velev, Maria Atanassova, Yana Aksentieva, Fatme Melbahtin Ahmet, Ralica Yordanova, Rumen Harizanov
The symptoms of COVID-19 include febrility and mainly catarrhal symptoms. In severe cases, patients present with progression to lower respiratory tract and acute respiratory distress (ARDS) and multi-organ dysfunction. Malaria caused by P. falciparum is a severe, endemic parasitosis, mainly in Africa. In some cases, it can be complicated with ARDS. We present a case of a patient who returned from Nigeria with respiratory symptoms, in which both COVID-19 infection and tropical malaria were proven; with a fatal outcome...
April 2024: Oxford Medical Case Reports
#29
JOURNAL ARTICLE
Renee Ti Chou, Amed Ouattara, Matthew Adams, Andrea A Berry, Shannon Takala-Harrison, Michael P Cummings
Malaria vaccine development is hampered by extensive antigenic variation and complex life stages of Plasmodium species. Vaccine development has focused on a small number of antigens, many of which were identified without utilizing systematic genome-level approaches. In this study, we implement a machine learning-based reverse vaccinology approach to predict potential new malaria vaccine candidate antigens. We assemble and analyze P. falciparum proteomic, structural, functional, immunological, genomic, and transcriptomic data, and use positive-unlabeled learning to predict potential antigens based on the properties of known antigens and remaining proteins...
April 27, 2024: NPJ Systems Biology and Applications
#30
JOURNAL ARTICLE
Nanang R Ariefta, Koichi Narita, Toshihiro Murata, Yoshifumi Nishikawa
The persistent prevalence and dissemination of drug-resistant malaria parasites continue to challenge the progress of malaria eradication efforts. As a result, there is an urgent need to search for and develop innovative therapies. In this study, we screened synthetic 2,5-diphenyloxazole analogs from Oxytropis lanata. Among 48 compounds, 14 potently inhibited the proliferation of P. falciparum strains 3D7 (chloroquine-sensitive) and K1 (multidrug-resistant) in vitro, exhibited IC50 values from 3.38 to 12.65 μM and 1...
April 18, 2024: International Journal for Parasitology, Drugs and Drug Resistance
#31
JOURNAL ARTICLE
Arsene Daniel Nyalundja, Patrick Musole Bugeme, Ashuza Shamamba Guillaume, Alain Balola Ntaboba, Victoire Urbain Hatu'm, Jacques Lukenze Tamuzi, Duduzile Ndwandwe, Chinwe Iwu-Jaja, Charles S Wiysonge, Patrick D M C Katoto
Two novel vaccines against malaria are proposed as a complementary control tool to prevent and reduce Plasmodium falciparum related disease and death in under-five children from moderate to high malaria transmission regions. The Democratic Republic of Congo (DRC) has committed to eradicate malaria by 2030, and significant efforts have been deployed to strengthen control and elimination measures. We aimed to understand factors influencing the malaria vaccine acceptability among the general population in eastern DRC...
April 2, 2024: Vaccines
#32
JOURNAL ARTICLE
William H Stump, Hayley J Klingenberg, Amy C Ott, Donna M Gonzales, James M Burns
Efficacy data on two malaria vaccines, RTS,S and R21, targeting Plasmodium falciparum circumsporozoite protein ( Pf CSP), are encouraging. Efficacy may be improved by induction of additional antibodies to neutralizing epitopes outside of the central immunodominant repeat domain of Pf CSP. We designed four r Pf CSP-based vaccines in an effort to improve the diversity of the antibody response. We also evaluated P. falciparum merozoite surface protein 8 ( Pf MSP8) as a malaria-specific carrier protein as an alternative to hepatitis B surface antigen...
March 25, 2024: Vaccines
#33
JOURNAL ARTICLE
Imen Abid, Wassim Moslah, Sandrine Cojean, Nicolas Imbert, Philippe M Loiseau, Alain Chamayou, Najet Srairi-Abid, Rachel Calvet, Michel Baltas
Chalcones are polyphenols that belong to the flavonoids family, known for their broad pharmacological properties. They have thus attracted the attention of chemists for their obtention and potential activities. In our study, a library of compounds from 2'-hydroxychalcone's family was first synthesized. A one-step mechanochemical synthesis via Claisen-Schmidt condensation reaction under ball mill conditions was studied, first in a model reaction between a 5'-fluoro-2'-hydroxyacetophenone and 3,4-dimethoxybenzaldehyde...
April 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#34
JOURNAL ARTICLE
Veera Venkata Nishanth Goli, Spandana Tatineni, Umme Hani, Mohammed Ghazwani, Sirajunisa Talath, Sathvik Belagodu Sridhar, Yahya Alhamhoom, Farhat Fatima, Riyaz Ali M Osmani, Umamaheshwari Shivaswamy, Vichitra Chandrasekaran, Bannimath Gurupadayya
Cerebral malaria (CM), a severe neurological pathology caused by Plasmodium falciparum infection, poses a significant global health threat and has a high mortality rate. Conventional therapeutics cannot cross the blood-brain barrier (BBB) efficiently. Therefore, finding effective treatments remains challenging. The novelty of the treatment proposed in this study lies in the feasibility of intranasal (IN) delivery of the nanostructured lipid carrier system (NLC) combining microRNA (miRNA) and artemether (ARM) to enhance bioavailability and brain targeting...
April 6, 2024: Pharmaceuticals
#35
JOURNAL ARTICLE
Carla Di Chio, Josè Starvaggi, Noemi Totaro, Santo Previti, Benito Natale, Sandro Cosconati, Marta Bogacz, Tanja Schirmeister, Jenny Legac, Philip J Rosenthal, Maria Zappalà, Roberta Ettari
In recent decades, neglected tropical diseases and poverty-related diseases have become a serious health problem worldwide. Among these pathologies, human African trypanosomiasis, and malaria present therapeutic problems due to the onset of resistance, toxicity problems and the limited spectrum of action. In this drug discovery process, rhodesain and falcipain-2, of Trypanosoma brucei rhodesiense and Plasmodium falciparum , are currently considered the most promising targets for the development of novel antitrypanosomal and antiplasmodial agents, respectively...
April 17, 2024: International Journal of Molecular Sciences
#36
JOURNAL ARTICLE
Amer Kareem, Haiming Liu, Vladan Velisavljevic
Malaria is one of the life-threatening diseases caused by the parasite known as Plasmodium falciparum, affecting the human red blood cells. Therefore, it is an important to have an effective computer-aided system in place for early detection and treatment. The visual heterogeneity of the malaria dataset is highly complex and dynamic, therefore higher number of images are needed to train the machine learning (ML) models effectively. However, hospitals as well as medical institutions do not share the medical image data for collaboration due to general data protection regulations (GDPR) and the data protection act (DPA)...
March 30, 2024: Bioengineering
#37
JOURNAL ARTICLE
Kassoum Kayentao, Aissata Ongoiba, Anne C Preston, Sara A Healy, Zonghui Hu, Jeff Skinner, Safiatou Doumbo, Jing Wang, Hamidou Cisse, Didier Doumtabe, Abdrahamane Traore, Hamadi Traore, Adama Djiguiba, Shanping Li, Mary E Peterson, Shinyi Telscher, Azza H Idris, William C Adams, Adrian B McDermott, Sandeep Narpala, Bob C Lin, Leonid Serebryannyy, Somia P Hickman, Andrew J McDougal, Sandra Vazquez, Matthew Reiber, Judy A Stein, Jason G Gall, Kevin Carlton, Philipp Schwabl, Siriman Traore, Mamadou Keita, Amatigué Zéguimé, Adama Ouattara, M'Bouye Doucoure, Amagana Dolo, Sean C Murphy, Daniel E Neafsey, Silvia Portugal, Abdoulaye Djimdé, Boubacar Traore, Robert A Seder, Peter D Crompton
BACKGROUND: Subcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal antibody administered subcutaneously can protect children from P. falciparum infection in a region where this organism is endemic is unclear. METHODS: We conducted a phase 2 trial in Mali to assess the safety and efficacy of subcutaneous administration of L9LS in children 6 to 10 years of age over a 6-month malaria season...
April 26, 2024: New England Journal of Medicine
#38
JOURNAL ARTICLE
Anthony Huffman, Xumeng Zhang, Meghana Lanka, Jie Zheng, Anna Maria Masci, Yongqun He
BACKGROUND: Pathogenic parasites are responsible for multiple diseases, such as malaria and Chagas disease, in humans and livestock. Traditionally, pathogenic parasites have been largely an evasive topic for vaccine design, with most successful vaccines only emerging recently. To aid vaccine design, the VIOLIN vaccine knowledgebase has collected vaccines from all sources to serve as a comprehensive vaccine knowledgebase. VIOLIN utilizes the Vaccine Ontology (VO) to standardize the modeling of vaccine data...
April 25, 2024: Journal of Biomedical Semantics
#39
JOURNAL ARTICLE
Jaiberth Antonio Cardona-Arias, Jaime Carmona-Fonseca
BACKGROUND: Pregnancy Associated Malaria (PAM) include malaria in pregnancy (MiP), placental malaria (PM), and congenital malaria (CM). The evidence available in Colombia on PAM focuses on one of the presentations (MiP, PM or CM), and no study longitudinally analyses the infection from the pregnant woman, passing through the placenta, until culminating in the newborn. This study determined the frequency of MiP, PM, and CM caused by Plasmodium vivax, Plasmodium falciparum, or mixed infections, according to Thick Blood Smear (TBS) and quantitative Polymerase Chain Reaction (qPCR)...
April 25, 2024: Malaria Journal
#40
JOURNAL ARTICLE
Mziyanda Mbaba, Taryn M Golding, Reinner O Omondi, Roxanne Mohunlal, Timothy J Egan, Janette Reader, Lyn-Marie Birkholtz, Gregory S Smith
Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising emergence of resistant malaria parasites, some of which have been reported for ACT, the usefulness of AQ as an efficacious therapeutic drug is threatened. Employing the organometallic hybridisation approach, which has been shown to restore the antimalarial activity of chloroquine in the form of an organometallic hybrid clinical candidate ferroquine (FQ), the present study utilises this strategy to modulate the biological performance of AQ by incorporating ferrocene...
April 16, 2024: European Journal of Medicinal Chemistry
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