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https://www.readbyqxmd.com/read/27904879/the-establishment-and-diversification-of-epidemic-associated-serogroup-w-meningococcus-in-the-african-meningitis-belt-1994-to-2012
#1
Adam C Retchless, Fang Hu, Abdoul-Salam Ouédraogo, Seydou Diarra, Kristen Knipe, Mili Sheth, Lori A Rowe, Lassana Sangaré, Absetou Ky Ba, Soumeya Ouangraoua, Dhwani Batra, Ryan T Novak, Rasmata Ouédraogo Traoré, Xin Wang
Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to cause epidemics. Neisseria meningitidis serogroup W remains a major cause of disease in the region, with most isolates belonging to clonal complex 11 (CC11). Here, the genetic variation within and between epidemic-associated strains was assessed by sequencing the genomes of 92 N...
November 2016: MSphere
https://www.readbyqxmd.com/read/27855873/household-transmission-of-neisseria-meningitidis-in-the-african-meningitis-belt-a-longitudinal-cohort-study
#2
(no author information available yet)
BACKGROUND: Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. METHODS: Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study...
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27855859/household-transmission-of-neisseria-meningitidis-in-the-meningitis-belt
#3
Sarah A Meyer, Paul A Kristiansen
No abstract text is available yet for this article.
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27826113/towards-understanding-the-epidemiology-of-neisseria-meningitidis-in-the-african-meningitis-belt-a-multi-disciplinary-overview
#4
REVIEW
Lydiane Agier, Nadège Martiny, Oumy Thiongane, Judith E Mueller, Juliette Paireau, Eleanor R Watkins, Tom J Irving, Thibaut Koutangni, Hélène Broutin
OBJECTIVES: Neisseria meningitidis is the major cause of seasonal meningitis epidemics in the African meningitis belt. In the changing context of a reduction in incidence of serogroup A and an increase in incidence of serogroups W and C and of Streptococcus pneumoniae, a better understanding of the determinants driving the disease transmission dynamics remains crucial to improving bacterial meningitis control. METHODS: The literature was searched to provide a multi-disciplinary overview of the determinants of meningitis transmission dynamics in the African meningitis belt...
November 5, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27820969/the-global-meningococcal-initiative-global-epidemiology-the-impact-of-vaccines-on-meningococcal-disease-and-the-importance-of-herd-protection
#5
Ray Borrow, Pedro Alarcón, Josefina Carlos, Dominique A Caugant, Hannah Christensen, Roberto Debbag, Philippe De Wals, Gabriela Echániz-Aviles, Jamie Findlow, Chris Head, Daphne Holt, Hajime Kamiya, Samir K Saha, Sergey Sidorenko, Muhamed-Kheir Taha, Caroline Trotter, Julio A Vázquez Moreno, Anne von Gottberg, Marco A P Sáfadi
The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization...
November 22, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27567107/emergence-of-epidemic-neisseria-meningitidis-serogroup-c-in-niger-2015-an-analysis-of-national-surveillance-data
#6
Fati Sidikou, Maman Zaneidou, Ibrahim Alkassoum, Stephanie Schwartz, Bassira Issaka, Ricardo Obama, Clement Lingani, Ashley Tate, Flavien Ake, Souleymane Sakande, Sani Ousmane, Jibir Zanguina, Issaka Seidou, Innocent Nzeyimana, Didier Mounkoro, Oubote Abodji, Xin Wang, Muhamed-Kheir Taha, Jean Paul Moulia-Pelat, Assimawe Pana, Goumbi Kadade, Olivier Ronveaux, Ryan Novak, Odile Ouwe Missi Oukem-Boyer, Sarah Meyer
BACKGROUND: To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV. METHODS: We compiled and analysed nationwide case-based meningitis surveillance data in Niger. Cases were confirmed by culture or direct real-time PCR, or both, of cerebrospinal fluid specimens, and whole-genome sequencing was used to characterise isolates...
August 23, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27449148/the-global-evolution-of-meningococcal-epidemiology-following-the-introduction-of-meningococcal-vaccines
#7
REVIEW
Stephen I Pelton
Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is associated with high morbidity and mortality. Although IMD incidence is highest in infants, a second peak occurs in adolescents/young adults. The incidence of IMD and the predominant disease-causing meningococcal serogroups vary worldwide. Epidemiologic data have guided the development of meningococcal vaccines to reduce the IMD burden. In Europe, serogroup C IMD has been substantially reduced since the introduction of a serogroup C conjugate vaccine...
August 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/27443772/surveillance-in-africa-s-meningitis-belt-time-for-new-targets
#8
Stephen K Obaro
No abstract text is available yet for this article.
August 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27435201/different-segments-of-the-cerebral-vasculature-reveal-specific-endothelial-specifications-while-tight-junction-proteins-appear-equally-distributed
#9
Sophie Hanske, Felix Dyrna, Ingo Bechmann, Martin Krueger
The identification of the "paucity of transportation vesicles" and "belt-like" tight junctions (TJs) of endothelial cells as the "morphological correlate of a blood-brain barrier" (BBB) by Reese and Karnovsky (J Cell Biol 34:207-217, 1967) has become textbook knowledge, and countless studies have helped to further define the elements, functions, and dynamics of the BBB. Most work, however, has focused on parenchymal capillaries or less clearly defined "microvessels", while a systematic study on similarities and differences between BBB architecture along the vascular tree within the brain and the meninges has been lacking...
July 19, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27396517/contribution-of-polio-eradication-initiative-to-effective-new-vaccine-introduction-in-africa-2010-2015
#10
Mable Carole Tevi-Benissan, Edna Moturi, Blanche-Philomene Melanga Anya, Teka Aschalew, Akanmori Barthlomew Dicky, Poy Alain Nyembo, Leon Kinuam Mbulu, Joseph Okeibunor, Richard Mihigo, Felicitas Zawaira
BACKGROUND: Significant progress has been made to increase access to vaccines in Africa since the 1974 launch of the Expanded Programme on Immunization (EPI). Successes include the introduction of several new vaccines across the continent and likely eradication of polio. We examined the contribution of polio eradication activities (PEI) on new vaccine introduction in the countries of the African Region. METHODS: We reviewed country specific PEI reports to identify best practices relevant to new vaccine introduction (NVI), and analyzed trends in vaccine coverage during 2010-2015 from immunization estimates provided by WHO/UNICEF...
October 10, 2016: Vaccine
https://www.readbyqxmd.com/read/27379429/correction-a-seroepidemiological-study-of-serogroup-a-meningococcal-infection-in-the-african-meningitis-belt
#11
Olivier Manigart, Caroline Trotter, Helen Findlow, Abraham Aseffa, Wude Mihret, Tesfaye Moti Demisse, Biruk Yeshitela, Isaac Osei, Abraham Hodgson, Stephen Laryea Quaye, Samba Sow, Mamadou Coulibaly, Kanny Diallo, Awa Traore, Jean-Marc Collard, Rahamatou Moustapha Boukary, Oumarou Djermakoye, Ali Elhaji Mahamane, Jean-François Jusot, Cheikh Sokhna, Serge Alavo, Souleymane Doucoure, El Hadj Ba, Mariétou Dieng, Aldiouma Diallo, Doumagoum Moto Daugla, Babatunji Omotara, Daniel Chandramohan, Musa Hassan-King, Maria Nascimento, Arouna Woukeu, Ray Borrow, James M Stuart, Brian Greenwood
[This corrects the article DOI: 10.1371/journal.pone.0147928.].
2016: PloS One
https://www.readbyqxmd.com/read/27314251/identification-of-streptococcus-suis-meningitis-through-population-based-surveillance-togo-2010-2014
#12
Haoua Tall, Berthe-Marie Njanpop-Lafourcade, Didier Mounkoro, Loukoumane Tidjani, Kodjo Agbenoko, Issifou Alassani, Moussa Amidou, Stanislas Tamekloe, Kenneth G Laing, Adam A Witney, Jason Hinds, Mark P G van der Linden, Bradford D Gessner, Jennifer C Moïsi
During 2010-2014, we enrolled 511 patients with suspected bacterial meningitis into surveillance in 2 districts of northern Togo. We identified 15 persons with Streptococcus suis infection; 10 had occupational contact with pigs, and 12 suffered neurologic sequelae. S. suis testing should be considered in rural areas of the African meningitis belt.
July 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27198841/seasonal-dynamics-of-bacterial-meningitis-a-time-series-analysis
#13
Juliette Paireau, Angelica Chen, Helene Broutin, Bryan Grenfell, Nicole E Basta
BACKGROUND: Bacterial meningitis, which is caused mainly by Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae, inflicts a substantial burden of disease worldwide. Yet, the temporal dynamics of this disease are poorly characterised and many questions remain about the ecology of the disease. We aimed to comprehensively assess seasonal trends in bacterial meningitis on a global scale. METHODS: We developed the first bacterial meningitis global database by compiling monthly incidence data as reported by country-level surveillance systems...
June 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27174237/incidence-and-types-of-adverse-events-during-mass-vaccination-campaign-with-the-meningococcal-a-conjugate-vaccine-menafrivac%C3%A2-in-cameroon
#14
Jerome Ateudjieu, Beat Stoll, Georges Nguefack-Tsague, Martin Ndinakie Yakum, Marcellin Nimpa Mengouo, Blaise Genton
PURPOSE: A new vaccine against meningitis A was introduced in Africa meningitis belt in 2010. This study was planned to describe the incidence and types of adverse events following immunization (AEFIs) with a new conjugate vaccine against meningitis A (MenAfrivac™) in a Cameroonian vaccination campaign. METHODS: The campaign was conducted in Adamawa and North West regions in December 2012 and the AEFIs enhanced surveillance from December 2012 to January 2013. Incidence rates (IR) of overall and serious AEFIs were estimated as well as AEFI incidence rates by type, age group and region...
May 13, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27108455/meningitis-control-in-countries-of-the-african-meningitis-belt-2015
#15
(no author information available yet)
No abstract text is available yet for this article.
April 22, 2016: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/27086142/meningococcal-vaccinations
#16
REVIEW
Nancy Crum-Cianflone, Eva Sullivan
Neisseria meningitidis, a gram-negative diplococcal bacterium, is a common asymptomatic nasopharyngeal colonizer that may infrequently lead to invasive disease in the form of meningitis or bacteremia. Six serogroups (A, B, C, W, X and Y) are responsible for the majority of invasive infections. Increased risk of disease occurs in specific population groups including infants, adolescents, those with asplenia or complement deficiencies, and those residing in crowded living conditions such as in college dormitories...
June 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27062987/meningococcal-disease-during-the-hajj-and-umrah-mass-gatherings
#17
Saber Yezli, Abdullah M Assiri, Rafat F Alhakeem, Abdulhafiz M Turkistani, Badriah Alotaibi
The Hajj and Umrah religious mass gatherings hosted by the Kingdom of Saudi Arabia can facilitate the transmission of infectious diseases. The pilgrimages have been associated with a number of local and international outbreaks of meningococcal disease. These include serogroup A disease outbreaks in 1987 and throughout the 1990s and two international serogroup W135 outbreaks in 2000 and 2001. The implementation of strict preventative measures including mandatory quadrivalent meningococcal vaccination and antibiotic chemoprophylaxis for pilgrims from the African meningitis belt has prevented pilgrimage-associated meningococcal outbreaks since 2001...
June 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27046926/-l%C3%A3-on-lapeyssonnie-on-the-trail-to-its-end
#18
Jean-Marie Milleliri
He would have celebrated his 100th birthday in 2015, but finally, it doesn't matter, since by leaving his name to African meningitis belt, that isohyetal band in sub-Saharan Africa where epidemics of cerebrospinal meningitis are rife, Lapeyssonnie, the trailblazer at the end of his trail, has gone straight into the textbooks of tropical medicine. There was probably nothing he enjoyed more than wandering the lateritic paths and Sudano-Sahelian bush in that zone. His first job, in the Mossi country in Upper Volta that had not yet become Burkina Faso, was of course an initiation...
January 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27036337/control-of-meningitis-outbreaks-in-the-african-meningitis-belt
#19
Stephen K Obaro, Abdulrazaq G Habib
No abstract text is available yet for this article.
April 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27018131/pharyngeal-carriage-of-neisseria-species-in%C3%A2-the-african-meningitis-belt
#20
Kanny Diallo, Caroline Trotter, Youssouf Timbine, Boubou Tamboura, Samba O Sow, Bassira Issaka, Ibrahim D Dano, Jean-Marc Collard, Marietou Dieng, Aldiouma Diallo, Adane Mihret, Oumer A Ali, Abraham Aseffa, Stephen L Quaye, Akalifa Bugri, Isaac Osei, Kadidja Gamougam, Lodoum Mbainadji, Doumagoum M Daugla, Galadima Gadzama, Zailani B Sambo, Babatunji A Omotara, Julia S Bennett, Lisa S Rebbetts, Eleanor R Watkins, Maria Nascimento, Arouna Woukeu, Olivier Manigart, Ray Borrow, James M Stuart, Brian M Greenwood, Martin C J Maiden
OBJECTIVES: Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection. METHODS: Neisseria isolates were collected during 18 surveys conducted in six countries in the African meningitis belt between 2010 and 2012 and characterized at the rplF locus to determine species and at the variable region of the fetA antigen gene...
June 2016: Journal of Infection
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