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https://www.readbyqxmd.com/read/28738439/terpenoids-from-the-oleo-gum-resin-of-boswellia-serrata-and-their-antiplasmodial-effects-in-vitro
#1
Hippolyt L Greve, Marcel Kaiser, Reto Brun, Thomas J Schmidt
In the course of our ongoing search for new natural products as leads against protozoal diseases, the dichloromethane extract of Indian frankincense, the oleo-gum-resin obtained from Boswellia serrata, showed in vitro activity against Plasmodium falciparum. Bioactivity-guided fractionation led to the isolation of eight diterpenes: (1S,3E,7E,11R)-verticilla-3,7,12(18)-triene (1), cembrene A (2), serratol (3), 1S,3E,7R,8R,11E-7,8-epoxy-cembra-3,11-dien-1-ol (4), incensole oxide (5), rel (1S,3R,7E,11S,12R)-1,12-epoxy-4-methylenecembr-7-ene-3, 11-diol (6), isoincensole oxide (7), and isodecaryiol (8)...
July 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28723662/acetyl-lupeolic-acid-inhibits-akt-signaling-and-induces-apoptosis-in-chemoresistant-prostate-cancer-cells-in-vitro-and-in-vivo
#2
Claudia Schmidt, Cornelia Loos, Lu Jin, Michael Schmiech, Christoph Q Schmidt, Menna El Gaafary, Tatiana Syrovets, Thomas Simmet
The triterpenoid acetyl-lupeolic acid (ac-LA) isolated from the oleogum resin of Boswellia carterii reduced the viability of a panel of cancer cell lines more efficiently than lupeol. There was no detectable intracellular conversion of ac-LA to lupeol and vice versa. In contrast to docetaxel, ac-LA did not induce selection of treatment-resistant cancer cells. By various parameters including DNA fragmentation, ac-LA was shown to induce apoptosis in androgen-independent PC-3 cells, whereas in MDA-MB-231 breast cancer cells, ac-LA led to cell accumulation in the G2/M phase of the cell cycle, but not to apoptosis...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28662360/adsorption-kinetics-isotherm-and-thermodynamics-studies-of-acetyl-11-keto-%C3%AE-boswellic-acids-akba-from-boswellia-serrata-extract-using-macroporous-resin
#3
Sonali S Niphadkar, Virendra K Rathod
An acetyl 11-keto-β-boswellic acid (AKBA) is potent anti-inflammatory agent found in Boswellia serrata oleogum resin. Adsorption characteristics of AKBA from Boswellia serrata were studied using macroporous adsorbent resin to understand separation and adsorption mechanism of targeted molecules. Different macroporus resins were screened for adsorption and desorption of AKBA and Indion 830 was screened as it showed higher adsorption capacity. The kinetic equations were studied and results showed that the adsorption of AKBA on Indion 830 was well fitted to the Pseudo first-order kinetic model...
June 29, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28595917/assessment-of-toxicity-and-biochemical-mechanisms-underlying-the-insecticidal-activity-of-chemically-characterized-boswellia-carterii-essential-oil-against-insect-pest-of-legume-seeds
#4
Kiran S, Anupam Kujur, Laluram Patel, Ramalakshmi K, Bhanu Prakash
The present study was undertaken to investigate the insecticidal activity of chemically characterized Boswellia carterii essential oil (EO) and its mode of action against the pulse beetle Callosobruchus chinensis and C. maculatus. GC-MS analysis depicted α-thujene (69.16%), α-Pinene (7.20) and α-Phellandrene (6.78%) as the major components of test EO. EO exhibited absolute toxicity at 0.10μl/ml air against both C. chinensis and C. maculatus following 24h exposure. EO caused a significant reduction in oviposition and further reproductive development at LC50 doses (0...
June 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28549801/methanolic-extract-of-boswellia-serrata-exhibits-anti-cancer-activities-by-targeting-microsomal-prostaglandin-e-synthase-1-in-human-colon-cancer-cells
#5
Tayebeh Ranjbarnejad, Massoud Saidijam, Shirin Moradkhani, Rezvan Najafi
BACKGROUND: Colorectal cancer (CRC) is the most common cancer. A proper method to reduce mortality of CRC is chemoprevention to prevent initiation and promotion of intestinal tumorgenesis. One of the promising and developing chemopreventive agents is natural compounds found in plants. Frankincense, the resin extract from the Boswellia specious, has been used in traditional and modern medicine for treating various diseases with very minimal side effects. In the current study, we investigated the anti-cancer activity of methanolic extract of Boswellia serrata (B...
May 24, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28537656/supplementation-with-a-lecithin-based-delivery-form-of-boswellia-serrata-extract-casperome%C3%A2-controls-symptoms-of-mild-irritable-bowel-syndrome
#6
G Belcaro, G Gizzi, L Pellegrini, M Corsi, M Dugall, M Cacchio, B Feragalli, S Togni, A Riva, R Eggenhoffner, L Giacomelli
OBJECTIVE: Irritable Bowel Syndrome (IBS) is a chronic, gastrointestinal disorder in which abdominal pain or discomfort is associated with defecation or changes in bowel habits. Its multifactorial pathophysiology leads to a variety of available treatments, mainly aimed at controlling symptoms. The management of IBS patients could be optimized by individualized strategies, including non-pharmaceutical approaches. In this study, we evaluated the efficacy and safety of a novel delivery form of Boswellia serrata extracts (BSE) (Casperome®) in patients with IBS...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28525862/application-of-nirs-coupled-with-pls-regression-as-a-rapid-non-destructive-alternative-method-for-quantification-of-kba-in-boswellia-sacra
#7
Ahmed Al-Harrasi, Najeeb Ur Rehman, Fazal Mabood, Muhammaed Albroumi, Liaqat Ali, Javid Hussain, Hidayat Hussain, René Csuk, Abdul Latif Khan, Tanveer Alam, Saif Alameri
In the present study, for the first time, NIR spectroscopy coupled with PLS regression as a rapid and alternative method was developed to quantify the amount of Keto-β-Boswellic Acid (KBA) in different plant parts of Boswellia sacra and the resin exudates of the trunk. NIR spectroscopy was used for the measurement of KBA standards and B. sacra samples in absorption mode in the wavelength range from 700-2500nm. PLS regression model was built from the obtained spectral data using 70% of KBA standards (training set) in the range from 0...
May 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28436338/the-effect-of-boswellia-serrata-resin-diet-supplementation-on-production-hematological-biochemical-and-immunological-parameters-in-broiler-chickens
#8
A R M Al-Yasiry, B Kiczorowska, W Samolińska, E Kowalczuk-Vasilev, D Kowalczyk-Pecka
Boswellia serrata resin (BSR), exhibiting a variety of therapeutic properties, is applied in Asian traditional medicine. These properties can be used in poultry production as well. Application of the resin as a phytobiotic in broiler chicken rearing can increase the productivity and improve meat quality. However, the optimum and maximum levels of BSR in broiler diets need to be assessed. The study determined the effect of different levels of supplementation of BSR (directly derived, unprocessed) in diets for broiler chickens on the production traits, selected slaughter analysis parameters, nutrient digestibility and selected hematological, biochemical and immunological parameters...
April 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28414519/effect-of-a-food-supplement-containing-l-methionine-on-urinary-tract-infections-in-pregnancy-a-prospective-multicenter-observational-study
#9
MULTICENTER STUDY
Mario Passaro, Giampaolo Mainini, Francesco Ambrosio, Raimondo Sgambato, Giancarlo Balbi
OBJECTIVE: Adjuvants or alternatives to antibiotics in urinary tract infections (UTIs) during pregnancy seem advisable because of possible fetal stress. The present study assessed the effectiveness of a food supplement containing L-methionine and Hibiscus sabdariffa L. and Boswellia serrata Roxb. extracts as a treatment for symptomatic UTIs in pregnancy. DESIGN: Pregnant patients with symptomatic cystitis were screened for UTIs in three different clinical centers...
June 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28403501/defined-structure-activity-relationships-of-boswellic-acids-determine-modulation-of-ca2-mobilization-and-aggregation-of-human-platelets-by-boswellia-serrata-extracts
#10
Ulf Siemoneit, Lars Tausch, Daniel Poeckel, Michael Paul, Hinnak Northoff, Andreas Koeberle, Johann Jauch, Oliver Werz
Boswellic acids constitute a group of unique pentacyclic triterpene acids from Boswellia serrata with multiple pharmacological activities that confer them anti-inflammatory and anti-tumoral properties. A subgroup of boswellic acids, characterized by an 11-keto group, elevates intracellular Ca(2+) concentrations [Ca(2+)]i and causes moderate aggregation of human platelets. How different BAs and their mixtures in pharmacological preparations affect these parameters in activated platelets has not been addressed, so far...
August 2017: Planta Medica
https://www.readbyqxmd.com/read/28392957/boswellic-acid-improves-cognitive-function-in-a-rat-model-through-its-antioxidant-activity-neuroprotective-effect-of-boswellic-acid
#11
Saeedeh Ebrahimpour, Mehdi Fazeli, Soghra Mehri, Mahnaz Taherianfard, Hossein Hosseinzadeh
OBJECTIVES: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. METHODS: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28386311/antioxidant-and-ex-vivo-immune-system-regulatory-properties-of-boswellia-serrata-extracts
#12
Daniela Beghelli, Gloria Isani, Paola Roncada, Giulia Andreani, Onelia Bistoni, Martina Bertocchi, Giulio Lupidi, Alessia Alunno
Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28375641/a-pilot-study-to-examine-the-effects-of-an-anti-inflammatory-supplement-on-eicosanoid-derivatives-in-patients-with-chronic-kidney-disease
#13
Brian D Shelmadine, Rodney G Bowden, Jennifer J Moreillon, Matthew B Cooke, Peiying Yang, Erika Deike, Jackson O Griggs, Ron L Wilson
BACKGROUND: Chronic kidney disease (CKD) is a progressive disease with an inverse relationship between kidney function and levels of inflammation and oxidative stress. Curcumin and Boswellia serrata have been reported to exert anti-inflammatory effects on the cyclooxygenase and lipoxygenase pathways. Therefore, the purpose of this study was to study the effects of a supplement containing curcumin and B. serrata on eicosanoid derivatives in early stage CKD patients who had not initiated hemodialysis...
April 4, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28349271/evaluation-of-the-effect-of-elaeagnus-angustifolia-alone-and-combined-with-boswellia-thurifera-compared-with-ibuprofen-in-patients-with-knee-osteoarthritis-a-randomized-double-blind-controlled-clinical-trial
#14
Mansoor Karimifar, Rasool Soltani, Valiollah Hajhashemi, Sara Sarrafchi
Osteoarthritis (OA) is one of the most common articular disorders. Many patients do not respond to acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs), the mainstay of pharmacotherapy for knee OA. The plants Elaeagnus angustifolia and Boswellia thurifera have anti-inflammatory and analgesic properties. This study aimed to evaluate the effect of E. angustifolia alone and in combination with B. thurifera compared with ibuprofen in patients with knee osteoarthritis. In a randomized double-blind controlled clinical trial, 75 patients with knee OA were randomly and equally assigned to one of three groups Elaeagnus (n = 23), Elaeagnus/Boswellia (n = 26), and ibuprofen (n = 26) to receive the capsules of Elaeagnus, Elaeagnus/Boswellia, and ibuprofen, respectively, three times daily with meals for 4 weeks...
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28332087/boswellia-ovalifoliolata-burseraceae-essential-oil-as-an-eco-friendly-larvicide-toxicity-against-six-mosquito-vectors-of-public-health-importance-non-target-mosquito-fishes-backswimmers-and-water-bugs
#15
Giovanni Benelli, Mohan Rajeswary, Periasamy Vijayan, Sengamalai Senthilmurugan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Marimuthu Govindarajan
The use of synthetic pesticides to control vector populations is detrimental to human health and the environment and may lead to the development of resistant strains. Plants can be alternative sources of safer compounds effective on mosquito vectors. In this study, the mosquito larvicidal activity of Boswellia ovalifoliolata leaf essential oil (EO) was evaluated against Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. GC-MS revealed that the B...
March 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28278495/antioxidant-supplements-and-gastrointestinal-diseases-a-critical-appraisal
#16
Islam Khan, Sue E Samson, Ashok Kumar Grover
The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions...
2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#17
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28245338/boswellia-serrata-resin-extract-alleviates-azoxymethane-aom-dextran-sodium-sulfate-dss-induced-colon-tumorigenesis
#18
Ya-Chun Chou, Joon Hyuk Suh, Yu Wang, Manoj Pahwa, Vladimir Badmaev, Chi-Tang Ho, Min-Hsiung Pan
SCOPE: Boswellia serrata (BS) resin is a popular dietary supplement for joint nourishment. In this study, we investigated the chemopreventive effects of dietary BS extract and its impact of gut microbiota on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated colon cancer in mice. METHODS AND RESULTS: Male ICR mice were injected with AOM and 2% DSS via drinking water. The mice were fed with 0.25 or 0.5% BS extract, and colonic tissue were collected at 15 weeks...
February 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28220202/enzyme-inhibitory-metabolites-from-endophytic-penicillium-citrinum-isolated-from-boswellia-sacra
#19
Sajid Ali, Abdul Latif Khan, Liaqat Ali, Tania Shamim Rizvi, Sumera Afzal Khan, Javid Hussain, Muhammad Hamayun, Ahmed Al-Harrasi
Fungal endophytes establish an important niche within the host plant through the secretion of chemical constituents. Isolation of bioactive metabolites could be a vital source for inhibiting the function of enzymes such as α-glucosidase and urease. The present study aimed to elucidate the potential of endophytes associated with Boswellia sacra through bioassay-guided isolation and identification of secondary metabolites with enzyme inhibitory ability. Endophytic fungal strains viz. Penicillium citrinum, P...
February 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28210929/effect-of-boswellia-serrata-resin-supplementation-on-basic-chemical-and-mineral-element-composition-in-the-muscles-and-liver-of-broiler-chickens
#20
A R M Al-Yasiry, B Kiczorowska, W Samolińska
Supplementation of broiler chicken diets with resin rich in bioactive components, such as different boswellic acids, could improve productivity, chemical composition, and nutritive value of produced meat. The aim of the study was to assess the effect of different levels of Boswellia serrata (BSR) supplementation in broiler chicken diet on the basic chemical composition and the Ca, P, Mg, Fe, Zn, and Cu contents in the breast and drumstick muscles and liver. The analyses involved 200 Ross 308 chickens. The broiler chickens were fed with diets containing 0 (BSR0), 1...
February 16, 2017: Biological Trace Element Research
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