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https://www.readbyqxmd.com/read/29623934/acetyl-11-keto-%C3%AE-boswellic-acid-extracted-from-boswellia-serrata-promotes-schwann-cell-proliferation-and-sciatic-nerve-function-recovery
#1
Xiao-Wen Jiang, Bin-Qing Zhang, Lu Qiao, Lin Liu, Xue-Wei Wang, Wen-Hui Yu
Frankincense can promote blood circulation. Acetyl-11-keto-β-boswellic acid (AKBA) is a small molecule with anti-inflammatory properties that is derived from Boswellia serrata. Here, we hypothesized that it may promote regeneration of injured sciatic nerve. To address this hypothesis, we established a rat model of sciatic nerve injury using a nerve clamping method. Rats were administered AKBA once every 2 days at doses of 1.5, 3, and 6 mg/kg by intraperitoneal injection for 30 days from the 1st day after injury...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29622343/efficacy-of-curcumin-and-boswellia-for-knee-osteoarthritis-systematic-review-and-meta-analysis
#2
Raveendhara R Bannuru, Mikala C Osani, Fatimah Al-Eid, Chenchen Wang
PURPOSE: The unfavorable safety profiles of commonly prescribed knee osteoarthritis (OA) treatments have led clinicians and patients to seek safer alternatives. Research has suggested that curcuminoid and boswellia formulations could moderate key inflammatory pathways that are associated with worsening symptoms and disease progression. We conducted a systematic review and meta-analysis to assess the efficacy and safety of these treatments vs. placebo or NSAIDs for knee OA. METHODS: We searched Medline, EMBASE, Google Scholar, Web of Science and the Cochrane database from inception to February 21, 2018...
March 10, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29582122/comprehensive-2d-gas-chromatography-time-of-flight-mass-spectrometry-with-2d-retention-indices-for-analysis-of-volatile-compounds-in-frankincense-boswellia-papyrifera
#3
Ming Jiang, Chadin Kulsing, Philip J Marriott
Frankincense gum resin secreted from Boswellia papyrifera was analysed by comprehensive 2D gas chromatography hyphenated with accurate mass time-of-flight mass spectrometry (GC×GC-accTOFMS). Direct multiple injection experiments with stepwise isothermal temperature programming were then performed to construct isovolatility curves for reference alkane series in GC×GC. This provides access to calculation of second dimensional retention indices (2 I). More than 500 peaks were detected and 220 compounds mainly comprising monoterpenes, sesquiterpenes, diterpenes and oxygenated forms of these compounds were identified according to their1 I,2 I and accurate mass data...
March 27, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29561773/the-complete-chloroplast-genome-sequence-of-tree-of-heaven-ailanthus-altissima-mill-sapindales-simaroubaceae-an-important-pantropical-tree
#4
Josphat K Saina, Zhi-Zhong Li, Andrew W Gichira, Yi-Ying Liao
Ailanthus altissima (Mill.) Swingle (Simaroubaceae) is a deciduous tree widely distributed throughout temperate regions in China, hence suitable for genetic diversity and evolutionary studies. Previous studies in A. altissima have mainly focused on its biological activities, genetic diversity and genetic structure. However, until now there is no published report regarding genome of this plant species or Simaroubaceae family. Therefore, in this paper, we first characterized A. altissima complete chloroplast genome sequence...
March 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29530608/frankincense-and-myrrh-essential-oils-and-burn-incense-fume-against-micro-inhabitants-of-sacral-ambients-wisdom-of-the-ancients
#5
Milica Ljaljević Grbić, Nikola Unković, Ivica Dimkić, Peđa Janaćković, Milan Gavrilović, Olja Stanojević, Miloš Stupar, Ljubodrag Vujisić, Aleksa Jelikić, Slaviša Stanković, Jelena Vukojević
ETHNOPHARMACOLOGICAL RELEVANCE: Essential oils obtained from resins of Boswellia carteri Birdw. and Commiphora myrrha (Nees) Engl., commonly known as frankincense and true myrrh respectively, have been used extensively since 2800 BCE for the treatment of skin sores, wounds, teeth, inflammation, and urinary tract diseases in traditional medicine; for preparation of mummification balms and unguents; and also as incense and perfumes. Since ancient times, burning of frankincense and myrrh in places of worship for spiritual purposes and contemplation (a ubiquitous practice across various religions) had hygienic functions, to refine the smell and reduce contagion by purifying the indoor air...
March 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29513961/neuroprotective-effect-of-boswellia-serrata-and-its-active-constituent-acetyl-11-keto-%C3%AE-boswellic-acid-against-oxygen-glucose-serum-deprivation-induced-cell-injury
#6
Hamid Reza Sadeghnia, Fatemeh Arjmand, Ahmad Ghorbani
Oxidative stress plays a key role in pathophysiology of brain ischemia. This study aimed to test whether B. serrata hydroalcoholic extract (BSE) and its active constituent 3-acetyl-1 1-keto-β-boswellic acid (AKBA) could protect neurons against ischemic condition induced by oxygen, glucose and serum deprivation (OGSD). First, PC12 neural cells were incubated with BSE (0-400 pg/mL) or AKBA (0-40 pg/mL) for 24 h to find non-cytotoxic concentrations of BSE and AKBA. Then, the cells were pre- (for 2 h) and co-treated with 1...
May 2017: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/29510602/evaluation-of-antimycobacterial-and-synergistic-activity-of-plants-selected-based-on-cheminformatic-parameters
#7
Nafise Rahgozar, Gholamreza Bakhshi Khaniki, Soroush Sardari
Background: Drug resistance is a major public health problem and a threat to progress made in bovine tuberculosis care and control worldwide. This study aimed at evaluating anti-mycobacterial and synergistic activity of some medicinal plants that were selected by cheminformatics studies against Mycobacterium bovis. Methods: Considering the strong synergistic antimycobacterial action of oleanolic acid in combination with tuberculosis drugs, NCBI database was explored to find the compounds with over 80% similarity to oleanolic acid, called S1...
March 7, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29506080/which-supplements-can-i-recommend-to-my-osteoarthritis-patients
#8
Xiaoqian Liu, Jillian Eyles, Andrew J McLachlan, Ali Mobasheri
OA is a chronic and disabling joint disease with limited evidence-based pharmacological treatment options available that improve outcomes for patients safely. Faced with few effective pharmacological treatments, the use has grown of dietary supplements and complementary medicines for symptomatic relief among people living with OA. The aim of this review is to provide a summary of existing evidence and recommendations supporting the use of supplements for OA. Systematic reviews and randomized controlled trials investigating oral supplements for treating OA were identified...
March 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29492734/conformational-analysis-of-macrocyclic-frankincense-boswellia-diterpenoids
#9
William N Setzer
Frankincense oleoresin has been used in traditional medicine for more than 5000 years. The phytochemistry of frankincense (Boswellia spp.) resins includes triterpenoids (including boswellic acids and their derivatives), diterpenoids (cembrenoids and cneorubenoids), and essential oils. The macrocyclic cembrene diterpenoids may play a part in the biological activities of frankincense resin, but neither the biological targets nor the modes of interaction with the targets are currently known. How these macrocycles interact with biological macromolecules likely depends on what conformation(s) are energetically available to them...
March 1, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29436996/herbal-products-for-common-auto-inflammatory-disorders-novel-approaches
#10
Fawzi Mahomoodally, Shanoo Suroowan
Common auto-inflammatory disorders (CAIDs) induce considerable suffering over the world. A panoply of synthetic medications areis available for theirits management. Nonetheless, available drug classes are limited by adverse effects, low systemic absorption, and high costs. In addition, no cure exists for most CAIDs. Interestingly, herbal products present a tremendous potential for development as anti-inflammatory agents. In this endeavor, major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse...
February 12, 2018: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29316908/efficacy-and-safety-of-curcumin-and-its-combination-with-boswellic-acid-in-osteoarthritis-a-comparative-randomized-double-blind-placebo-controlled-study
#11
RANDOMIZED CONTROLLED TRIAL
Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan, Areg Hovhannisyan
BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial...
January 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29314317/quantification-of-incensole-in-three-boswellia-species-by-nir-spectroscopy-coupled-with-plsr-and-cross-validation-by-hplc
#12
Sulaiman Al-Shidhani, Najeeb Ur Rehman, Fazal Mabood, Muhammed Al-Broumi, Hidayat Hussain, Javid Hussain, Rene Csuk, Ahmed Al-Harrasi
INTRODUCTION: Incensole can be considered as a biomarker for Boswellia species which is a diterpene that has received remarkable pharmacological interest recently due to its potent anti-inflammatory and anti-depressant activity. OBJECTIVE: Near-infrared (NIR) spectroscopy coupled with PLSR (partial least squares regression) as a robust, rapid and alternative method was used to quantify the content of incensole in three species namely B. papyrifera, B. sacra and B...
May 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29306113/the-effect-of-tablet-containing-boswellia-serrata-and-melisa-officinalis-extract-on-older-adults-memory-a-randomized-controlled-trial
#13
Mohsen Taghizadeh, Farzaneh Maghaminejad, Mohammad Aghajani, Malihe Rahmani, Mohaddese Mahboubi
BACKGROUND: Memory deficits and age-related memory loss are currently two significant concerns in older adults. In Iranian herbal medicine, there are some prescriptions for memory improvement. OBJECTIVE: This study was designed to investigate the effect of tablet containing Boswellia serrata (BS) extract and Mellisa officinalis (MO) extract on memory of the older adults. METHOD: This is a randomized, parallel, double-blind, placebo-controlled clinical trial that performed among 70 older adults who referred to healthcare centers of Kashan University of Medical Sciences, Iran...
March 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29259631/evaluating-the-efficacy-of-mixture-of-boswellia-carterii-zingiber-officinale-and-achillea-millefolium-on-severity-of-symptoms-anxiety-and-depression-in-irritable-bowel-syndrome-patients
#14
Afarin Kazemian, Ali Toghiani, Katayoun Shafiei, Hamid Afshar, Rahmatollah Rafiei, Mahnaz Memari, Peyman Adibi
Background: Irritable bowel syndrome (IBS) is the most prevalent functional gastrointestinal disorders (FGIDs) that affects in different aspects of life and patients experienced depression and anxiety more than others. There are several herbal medicines with positive effects in these patients. The aim of this study is to evaluate the effects of mixture of Boswellia carterii , Zingiber officinale , and Achillea Millefolium on severity of symptoms, anxiety, and depression in IBS patients...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29228792/silymarin-olibanum-and-nettle-a-mixed-herbal-formulation-in-the-treatment-of-type-ii-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#15
Nahid Khalili, Reza Fereydoonzadeh, Reza Mohtashami, Saeed Mehrzadi, Mojtaba Heydari, Hasan Fallah Huseini
Silybum marianum (L) Gaertn (milk thistle) seeds, Urtica dioica L (nettle) leaves, and Boswellia serrata (olibanum gum) resin are used traditionally by Iranian diabetic patients. The aim of this study was to evaluate the antihyperglycemic effects of these herbs in an herbal formulation in patients with type II diabetes mellitus. Sixty patients diagnosed as type II diabetes mellitus with fasting blood glucose level from 150 to 180 mg/dL, glycosylated hemoglobin level from 7.5% to 8.5%, and on oral antihyperglycemic drugs, were allocated to receive the mix herbal formulation or placebo for 90 days in a double-blind randomized placebo-controlled clinical trial...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228442/a-novel-boswellic-acids-delivery-form-casperome%C3%A2-in-the-management-of-musculoskeletal-disorders-a-review
#16
A Riva, P Allegrini, F Franceschi, S Togni, L Giacomelli, R Eggenhoffner
Standard pharmacological treatment of musculoskeletal conditions is often associated with relevant side effects. Botanical preparations endowed with a good tolerability profile, therefore, could have a role in the management of these disorders. Among different natural products, Boswellia serrata extracts have long been used for the treatment of musculoskeletal disorders, given their marked anti-inflammatory activity and their ability to promote tissue regeneration. However, standard preparations of Boswellia serrata show overall modest pharmacokinetic properties, a limitation which may ultimately lead to reduced efficacy...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29210124/a-novel-herbal-composition-containing-extracts-of-boswellia-serrata-gum-resin-and-aegle-marmelos-fruit-alleviates-symptoms-of-asthma-in-a-placebo-controlled-double-blind-clinical-study
#17
Pothina Yugandhar, Konda Manikyeswara Rao, Krishanu Sengupta
LI13109F is a novel herbal composition containing the extracts of Boswellia serrata gum resin and Aegle marmelos fruit. This composition dampens leukotriene dependent inflammatory reactions via inhibiting 5-lipoxygenase pathway. In a Sephadex LH-20 induced airway inflammation model of Sprague Dawley rats, LI13109F significantly reduced infiltrated granulocyte population in the bronco-alveolar lavage fluid and normalized Th1/Th2 cytokine balance. Further, a 56-day placebo-controlled and randomized double blind study (Clinical Trial Registration No...
January 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168653/utilizing-biomarkers-in-colorectal-cancer-an-interview-with-ajay-goel
#18
Ajay Goel
Ajay Goel speaks to Rachel Jenkins, Commissioning Editor. Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters...
December 2017: Future Oncology
https://www.readbyqxmd.com/read/29157812/the-major-boswellia-serrata-active-3-acetyl-11-keto-%C3%AE-boswellic-acid-strengthens-interleukin-1%C3%AE-upregulation-of-matrix-metalloproteinase-9-via-jnk-map-kinase-activation
#19
Elia Ranzato, Simona Martinotti, Andrea Volante, Aldo Tava, Maria Angela Masini, Bruno Burlando
BACKGROUND: Boswellia serrata gum resin has attracted pharmacological interest as an alternative antinflammatory. PURPOSE: We studied the application of an ethanolic extract of the resin and its main active 3-O-acetyl-11-keto-β-boswellic acid (AKBA) against inflammatory degeneration of skin extracellular matrix. STUDY DESIGN: We compared the effects of the extract and AKBA on the activity of MMP-2 and MMP-9 (72-kDa and 92-kDa type IV collagenases) in HaCaT keratinocytes exposed to interleukin-1α (IL-1α) as a skin inflammation model...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29127772/interventions-for-treating-collagenous-colitis
#20
REVIEW
Tahir S Kafil, Tran M Nguyen, Petrease H Patton, John K MacDonald, Nilesh Chande, John Wd McDonald
BACKGROUND: Collagenous colitis is a cause of chronic diarrhea. This updated review was performed to identify therapies for collagenous colitis that have been assessed in randomized controlled trials (RCTs). OBJECTIVES: The primary objective was to assess the benefits and harms of treatments for collagenous colitis. SEARCH METHODS: We searched CENTRAL, the Cochrane IBD Group Specialized Register, MEDLINE and EMBASE from inception to 7 November 2016...
November 11, 2017: Cochrane Database of Systematic Reviews
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