Paula Saá, Rebecca V Fink, Sonia Bakkour, Jing Jin, Graham Simmons, Marcus O Muench, Hina Dawar, Clara Di Germanio, Alvin J Hui, David J Wright, David E Krysztof, Steven H Kleinman, Angela Cheung, Theresa Nester, Debra A Kessler, Rebecca L Townsend, Bryan R Spencer, Hany Kamel, Jacquelyn M Vannoy, Honey Dave, Michael P Busch, Susan L Stramer, Mars Stone, Rachael P Jackman, Philip J Norris
Respiratory viruses such as influenza do not typically cause viremia; however, SARS-CoV-2 has been detected in the blood of COVID-19 patients with mild and severe symptoms. Detection of SARS-CoV-2 in blood raises questions about its role in pathogenesis as well as transfusion safety concerns. Blood donor reports of symptoms or a diagnosis of COVID-19 after donation (post-donation information, PDI) preceded or coincided with increased general population COVID-19 mortality. Plasma samples from 2,250 blood donors who reported possible COVID-19-related PDI were tested for the presence of SARS-CoV-2 RNA...
September 1, 2022: Journal of Clinical Investigation