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https://www.readbyqxmd.com/read/29672850/ursolic-acid-ameliorates-ccl4-induced-liver-fibrosis-through-the-noxs-ros-pathway
#1
Dakai Gan, Wang Zhang, Chenkai Huang, Jiang Chen, Wenhua He, Anjiang Wang, Bimin Li, Xuan Zhu
Liver fibrosis is a reversible wound-healing response that occurs after liver injury. NADPH oxidases (NOXs) and reactive oxygen species (ROS) which are expressed in hepatocytes (HCs), hepatic stellate cells (HSCs), and Kupffer cells (KCs) play an important role in the development of hepatic fibrosis. In in vitro studies, we had shown that ursolic acid (UA) could reverse liver fibrosis by inhibiting the activation of NOX-mediated fibrotic signaling networks in HSCs. In this study, we verified that UA could alleviate CCl4-induced liver fibrosis by reducing the expression of NOXs/ROS in HCs, HSCs, KCs...
April 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29670908/liver-x-receptor-inverse-agonist-sr9243-suppresses-nonalcoholic-steatohepatitis-intrahepatic-inflammation-and-fibrosis
#2
Peng Huang, Benson Kaluba, Xiao-Lin Jiang, Shi Chang, Xiao-Feng Tang, Lin-Feng Mao, Zhi-Peng Zhang, Fei-Zhou Huang
Abnormal metabolism of cholesterol may be a contributing factor in nonalcoholic steatohepatitis (NASH) pathogenesis. Accumulating evidence has shown that liver X receptor (LXR) is closely related to intrahepatic inflammation and fibrosis. In this study, we evaluated the effects of a novel liver-specific LXR inverse agonist, SR9243, on antifibrosis in NASH mice. A high-cholesterol diet was employed to induce NASH in BALB/c mice by either carbon tetrachloride (CCL4) administration or bile-duct ligation (BDL)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669958/allyl-isothiocyanate-reduces-liver-fibrosis-by-regulating-kupffer-cell-activation-in-rats
#3
Jeongtae Kim, Hyojin Bang, Meejung Ahn, Yuna Choi, Gi Ok Kim, Taekyun Shin
Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4 ). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl4 . Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl4 significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl4 -intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining...
April 17, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29669317/palmitate-activates-ccl4-expression-in-human-monocytic-cells-via-tlr4-myd88-dependent-activation-of-nf-%C3%AE%C2%BAb-mapk-pi3k-signaling-systems
#4
Shihab Kochumon, Ajit Wilson, Betty Chandy, Steve Shenouda, Jaakko Tuomilehto, Sardar Sindhu, Rasheed Ahmad
BACKGROUND/AIMS: Obesity is associated with adipose tissue inflammation which plays a key role in the development of insulin resistance and type 2 diabetes (T2D). Saturated free fatty acids (SFAs) levels are found to be elevated in obesity and T2D. Chemokines are known to have potent inflammatory functions in a wide range of biological processes linked to immunological disorders. Since CCL4 (Chemokine (C-C motif) ligand 4), also known as macrophage inflammatory protein-1β (MIP-1β), plays an important role in the migration of monocytes into the adipose tissue, we investigated the expression of CCL4 in monocytic cells/macrophages following activation with free fatty acid palmitate...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29665135/hepatocellular-carcinoma-is-associated-with-gut-microbiota-profile-and-inflammation-in-non-alcoholic-fatty-liver-disease
#5
Francesca Romana Ponziani, Sherrie Bhoori, Chiara Castelli, Lorenza Putignani, Licia Rivoltini, Federica Del Chierico, Maurizio Sanguinetti, Daniele Morelli, Francesco Paroni Sterbini, Valentina Petito, Sofia Reddel, Riccardo Calvani, Chiara Camisaschi, Anna Picca, Alessandra Tuccitto, Antonio Gasbarrini, Maurizio Pompili, Vincenzo Mazzaferro
The gut-liver axis plays a pivotal role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), which is the third cause of hepatocellular carcinoma (HCC) worldwide. However, the link between gut microbiota and hepatocarcinogenesis remains to be clarified. The aim of this study is to explore what features of the gut microbiota are associated with HCC in cirrhotic patients with NAFLD. A consecutive series of patients with NAFLD-related cirrhosis and HCC (group 1: 21 patients), NAFLD-related cirrhosis without HCC (group 2: 20 patients) and healthy controls (group 3: 20 patients) was studied for gut microbiota profile, intestinal permeability, inflammatory status and circulating mononuclear cells...
April 17, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29663826/antioxidant-and-hepato-preventive-effect-of-citrus-aurantium-extract-against-carbon-tetrachloride-induced-hepatotoxicity-in-rats-and-characterisation-of-its-bioactive-compounds-by-hplc-ms
#6
Anis Ben Hsouna, Manel Gargouri, Wissal Dhifi, Walid Saibi
The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4 ) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Administration of a single dose of CCl4 caused hepatoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) and in protein carbonyl level but a decrease in antioxidant markers in the liver tissue...
April 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29663566/mir-27a-3p-and-mir-124-3p-upregulated-in-endometrium-and-serum-from-women-affected-by-chronic-endometritis-are-new-potential-molecular-markers-of-endometrial-receptivity
#7
Cinzia Di Pietro, Salvatore Caruso, Rosalia Battaglia, Marco Iraci Sareri, Alessandro La Ferlita, Fabrizio Strino, Gabriele Bonaventura, Maurizio Di Mauro, Maria Luisa Barcellona, Vincenzo Perciavalle, Michele Purrello, Antonio Cianci
PROBLEM: Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein-encoding genes in CE has been demonstrated, but no evidence about the involvement of microRNAs in the pathology is present in literature. METHOD OF STUDY: In the endometrium from 15 women with CE and 15 healthy women, by RT-qPCR single assays, we investigated some microRNAs targeting IL11, CCL4, IGF1, and IGFBP1, which mRNAs had been found differentially expressed in endometrium of women affected by CE...
April 16, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29660654/assessment-of-the-possible-roles-of-sb-269970-versus-ketanserin-on-carbon-tetrachloride-induced-liver-fibrosis-in-rats-oxidative-stress-tgf-%C3%AE-1-induced-hscs-activation-pathway
#8
Marwa Ahmed Amin Atallah, Samah M Elaidy, Mona K Tawfik
BACKGROUND: In liver fibrosis, a major morbid and mortal disease, oxidative stress motivation of hepatic stellate cells (HSCs)-into myofibroblasts terminated in collagen deposition remain the key pathophysiological deal. Serotonin (5-HT) through its HSCs-expressed receptors, especially 5-HT2A and 7, shows crucial events in fibrogenesis of chronic liver diseases. Molecular hepatic oxidative stress-fibrotic roles of 5-HT2A and 7 receptors antagonists (ketanserin and SB-269970 respectively) are still a challenging issue...
November 28, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29656332/rdh13-deficiency-weakens-carbon-tetrachloride-induced-liver-injury-by-regulating-spot14-and-cyp2e1-expression-levels
#9
Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang
Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated Rdh13 knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl4 ). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the Rdh13-/- mice displayed an attenuated response to CCl4 -induced liver injury...
April 14, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29653399/contribution-to-the-development-of-low-frequency-terahertz-coherent-raman-micro-spectroscopy-and-microscopy
#10
Laszlo Ujj
We report the construction and characterization of a coherent Raman tabletop system utilizing a novel astigmatic optical focusing geometry, a broadband nanosecond optical parametric oscillator and volumetric Bragg filters assisting 3CBCRS measuring system for the first time. In order to illustrate the versatility of the measurements and reveal the molecular information obtainable, two well-characterized chemicals were selected. Polarization sensitive epi-detected 3CBCRS spectra of liquid CCl4 and calcite crystal were recorded and analyzed...
March 14, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29653172/characterization-antioxidant-activity-and-hepatoprotective-effect-of-purple-sweetpotato-polysaccharides
#11
Jian Sun, Bo Zhou, Chao Tang, Yarun Gou, Hong Chen, Yao Wang, Changhai Jin, Jun Liu, Fuxiang Niu, Juan Kan, Chunlu Qian, Nianfeng Zhang
In this study, three kinds of polysaccharides (named PSWP, PSAP-1 and PSAP-2) were successively isolated from purple sweetpotato tubers by hot water, 0.5 M and 2 M sodium hydroxide solutions. The characterization, in vitro antioxidant activity and in vivo hepatoprotective effect of these polysaccharides were investigated. Results indicated that PSWP, PSAP-1 and PSAP-2 were all β-type polysaccharides containing different contents of uronic acid, protein and polyphenol. Both PSWP and PSAP-1 were composed by arabinose, glucose and galactose, whereas PSAP-2 was consisted of arabinose, rhamnose and glucose...
April 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29652027/pokeweed-antiviral-protein-attenuates-liver-fibrosis-in-mice-through-regulating-wnt-jnk-mediated-glucose-metabolism
#12
Yonghong Zhang, Xiaolan Yu, Zheng Wang, Ming Yin, Zonghao Zhao, Yi Li, Wenting Li
Background/Aims: Pokeweed antiviral protein (PAP) has been reported to downregulate Wnt/Jnk pathway and attenuate liver fibrosis. This study was designed to intensively explore the mechanism of anti-fibrosis effect of PAP. Materials and Methods: Hepatic stellate cell (HSC) activation was induced by high concentration of glucose. Cell viability was detected at different time points after PAP treatment. Meanwhile, hepatic fibrosis models in mice were induced by CCl4 injection...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29651210/effects-of-alternanthera-sessilis-on-liver-function-in-carbon-tetra-chloride-induced-hepatotoxicity-in-wister-rat-model
#13
Biman Bhuyan, Krishna Baishya, Prakash Rajak
Alternanthera sessilis commonly known as 'sessile joy weed' or 'dwarf copperleaf' is found throughout the hotter parts of India up to an altitude of 1200 m2 . In Assam, the plant has been traditionally used in the treatment of jaundice along with other ailments. The study focuses primarily on the evaluation of hepatoprotective activity of the plant with special references to its putative protective role in carbon tetrachloride induced liver injury on Wister albino rat. The in vivo hepatoprotective activity of the methanolic extract at the dose of 250 mg/kg body weight was highly effective in controlling SGPT, SGOT, ALP, serum cholesterol and serum bilirubin level as compared to silymarin...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29649237/bronchoalveolar-lavage-bal-cells-in-idiopathic-pulmonary-fibrosis-express-a-complex-pro-inflammatory-pro-repair-angiogenic-activation-pattern-likely-associated-with-macrophage-iron-accumulation
#14
Jungnam Lee, Ivan Arisi, Ermanno Puxeddu, Lazarus K Mramba, Massimo Amicosante, Carmen M Swaisgood, Marco Pallante, Mark L Brantly, C Magnus Sköld, Cesare Saltini
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause characterized by alveolar epithelial damage, patchy interstitial fibrosis and diffuse microvascular abnormalities. In IPF, alveolar clustering of iron-laden alveolar macrophages-a common sign of microhemorrhage, has been associated with vascular abnormalities and worsening of pulmonary hypertension. As iron-dependent ROS generation has been shown to induce unrestrained macrophage activation in disease models of vascular damage, we explored alveolar macrophage activation phenotype in IPF patients (n = 16) and healthy controls (CTR, n = 7) by RNA sequencing of bronchoalveolar lavage (BAL) cells...
2018: PloS One
https://www.readbyqxmd.com/read/29648970/posttreatment-effects-of-olea-europaea-l-leaf-extract-on-carbon-tetrachloride-induced-liver-injury-and-oxidative-stress-in-rats
#15
Derya Ustuner, Emine Colak, Murat Dincer, Neslihan Tekin, Dilek Burukoglu Donmez, Fahrettin Akyuz, Ertugrul Colak, Umut Kerem Kolac, Emre Entok, Mehmet Cengiz Ustuner
The aim of this study is to examine the therapeutic effects of Olea europaea L. leaf extract on carbon tetrachloride (CCl4 )-induced liver damage in rats. In the experiments, 3- to 4-month-old 28 male Sprague-Dawley rats were divided into four groups: control, O. europaea leaf extract, CCl4 , and curative. The CCl4 and curative groups received CCl4 (0.2 mL/kg) intraperitoneally for 10 days to form hepatic injury. O. europaea (80 mg/kg) leaf extract was given orally to the curative group dissolved in distilled water the following 14 days...
March 20, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29629570/modulatory-effects-of-rosemary-leaves-aqueous-extraction-against-oxidative-stress-and-related-damages-in-experimental-model-of-ccl4-induced-cardiac-toxicity-in-mice
#16
Houda Hamed, Khaled Bellassoued, Noura Brahmi, Ahmed Gargouri, Zied Ghannoudi, Abdelfattah El Feki
Rosmarinus officialis L., Lamiaceae, has been traditionally used in Tunisia to treat several diseases. The aim of the present study is to analyze the cardiopreventive effect of Aqueous Extract of Rosemary (Rosmarinus officinalis) Leaves (AERL) against oxidative stress induced by carbon tetrachloride in experimental mice. The current study was performed on female Wistar mice divided into four groups of seven animals each. Cardiotoxity was induced by a single intraperitoneal injection of CCl4 (10ml/kg in 0.3 % olive oil) in mice which were gavaged daily with 100 mg of AERL for 15 days...
April 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29627643/contribution-of-alcohol-radicals-to-contaminant-degradation-in-quenching-studies-of-persulfate-activation-process
#17
Changyin Zhu, Fengxiao Zhu, Dionysios D Dionysiou, Dongmei Zhou, Guodong Fang, Juan Gao
Alcohols such as ethanol (EtOH) and tert-butanol (TBA) are frequently used as quenching agents to identify the primary radical species in the persulfate (PS)-based oxidation processes. However, the contribution of alcohol radicals (ARs) to contaminant degradation in this process has rarely been assessed. In this study, trichloroacetic acid (TCA), phenol, and carbon tetrachloride were selected as probes to test the role of ARs in the thermally activated PS system. It was found that the degradation rates of these compounds were largely depended on their reactivities with ARs and the concentration of dissolved oxygen in the reaction system...
March 31, 2018: Water Research
https://www.readbyqxmd.com/read/29626529/pre-vs-post-treatment-with-melatonin-in-ccl-4-induced-liver-damage-oxidative-stress-inferred-from-biochemical-and-pathohistological-studies
#18
Vanja P Ničković, Tatjana Novaković, Slavica Lazarević, Ljiljana Šulović, Zorica Živković, Jovan Živković, Bojan Mladenović, Nikola M Stojanović, Vladmir Petrović, Dušan T Sokolović
AIMS: The present study was designed to compare the ameliorating potential of pre- and post-treatments with melatonin, a potent natural antioxidant, in the carbon tetrachloride-induced rat liver damage model by tracking changes in enzymatic and non-enzymatic liver tissue defense parameters, as well as in the occurring pathohistological changes. MAIN METHODS: Rats from two experimental groups were treated with melatonin before and after CCl4 administration, while the controls, negative and positive, received vehicle/melatonin and CCl4 , respectively...
April 4, 2018: Life Sciences
https://www.readbyqxmd.com/read/29620210/saikosaponin%C3%A2-d-alleviates-carbon%C3%A2-tetrachloride-induced-acute-hepatocellular-injury-by-inhibiting-oxidative-stress-and-nlrp3-inflammasome-activation-in-the-hl%C3%A2-7702-cell-line
#19
Liubing Lin, Renye Que, Yanting Shen, Yirong Chen, Ni Yan, Yong Li
Saikosaponin‑d (SSd) the primary active component of triterpene saponin derived from Bupleurum falcatum L., possesses anti‑inflammatory and antioxidant properties. The present study aimed to examine the potential therapeutic effects of SSd on carbon tetrachloride (CCl4)‑induced acute hepatocellular injury in the HL‑7702 cell line and its underlying mechanisms. HL‑7702 cells were treated with SSd at different doses (0.5, 1 or 2 µmol/l). Cell viability was determined using an MTT assay. Injury was assessed by the levels of serum alanine aminotransferase (ALT) and aspartate transaminase (AST)...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29606345/gene-polymorphisms-in-the-ccl5-ccr5-pathway-as-a-genetic-biomarker-for-outcome-and-hand-foot-skin-reaction-in-metastatic-colorectal-cancer-patients-treated-with-regorafenib
#20
Mitsukuni Suenaga, Marta Schirripa, Shu Cao, Wu Zhang, Dongyun Yang, Yan Ning, Chiara Cremolini, Carlotta Antoniotti, Beatrice Borelli, Tetsuo Mashima, Satoshi Okazaki, Martin D Berger, Yuji Miyamoto, Roel Gopez, Afsaneh Barzi, Sara Lonardi, Toshiharu Yamaguchi, Alfredo Falcone, Fotios Loupakis, Heinz-Josef Lenz
BACKGROUND: The C-C motif chemokine ligand 5/C-C motif chemokine receptor 5 (CCL5/CCR5) pathway has been shown to induce endothelial progenitor cell migration, resulting in increased vascular endothelial growth factor A expression. We hypothesized that genetic polymorphisms in the CCL5/CCR5 pathway predict efficacy and toxicity in patients with metastatic colorectal cancer (mCRC) treated with regorafenib. PATIENTS AND METHODS: We analyzed genomic DNA extracted from 229 tumor samples from 2 different cohorts of patients who received regorafenib: an evaluation cohort of 79 Japanese patients and a validation cohort of 150 Italian patients...
February 27, 2018: Clinical Colorectal Cancer
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