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https://www.readbyqxmd.com/read/29237572/the-role-of-adipor1-and-adipor2-in-liver-fibrosis
#1
Badr Alzahrani, Tristan Iseli, Mehdi Ramezani-Moghadam, Vikki Ho, Miriam Wankell, Eun Jin Sun, Liang Qiao, Jacob George, Lionel W Hebbard
Activation of the adiponectin (APN) signaling axis retards liver fibrosis. However, understanding of the role of AdipoR1 and AdipoR2 in mediating this response is still rudimentary. Here, we sought to elucidate the APN receptor responsible for limiting liver fibrosis by employing AdipoR1 and AdipoR2 knock-out mice in the carbon tetrachloride (CCl4) model of liver fibrosis. In addition, we knocked down receptor function in primary hepatic stellate cells (HSCs) in vitro. Following the development of fibrosis, AdipoR1 and AdipoR2 KO mice had no quantitative difference in fibrosis by Sirius red staining...
December 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29237464/tlr3-promotes-mmp-9-production-in-primary-human-airway-epithelial-cells-through-wnt-%C3%AE-catenin-signaling
#2
P-J Royer, K Henrio, M Pain, J Loy, A Roux, A Tissot, P Lacoste, C Pison, S Brouard, A Magnan
BACKGROUND: Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Yet, the modalities of pathogen recognition by AEC and the consequences on the epithelial barrier remain poorly documented. METHOD: We investigated the response of primary human AEC to viral (polyinosinic-polycytidylic acid, poly(I:C)) and bacterial (lipopolysaccharide, LPS) stimulations in combination with the lung remodeling factor Transforming Growth Factor-β (TGF-β)...
December 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29234415/1h-nmr-based-serum-metabolomics-study-to-investigate-hepatoprotective-effect-of-qin-jiao-on-carbon-tetrachloride-induced-acute-hepatotoxicity-in-rats
#3
Zeyun Li, Ying Li, Lingpan Lu, Zhiheng Yang, Wenhua Xue, Xin Tian, Xiaojian Zhang
Gentiana macrophylla Radix, commonly known as Qin-Jiao (QJ), was recorded alone to treat jaundice in Compendium of Materia Medica and has been frequently prescribed for treatment of liver disease in China. However, the underlying mechanism remains unknown. In the present work, QJ of 1,2 g/kg or silybin of 40 mg/kg (positive control) was orally given to rats for 7 days to verify the protective effect on acute liver damage induced by tetrachloride (CCl4). Together with serum biochemistry and histopathological examination, 1H-NMR based metabolomics work was carried out to investigate the efficacy...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233029/molecular-hepatoprotective-effects-of-lipoic-acid-against-carbon-tetrachloride-induced-liver-fibrosis-in-rats-hepatoprotection-at-molecular-level
#4
K M Sadek, E A Saleh, S M Nasr
BACKGROUND: Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against liver fibrosis. AIM: Subsequently, in the present study, the viability of alpha-lipoic acid (α-LA) in ensuring against carbon tetrachloride (CCl4)-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were considered in rats...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29229868/sex-dependent-differences-in-inflammatory-responses-during-liver-regeneration-in-a-murine-model-of-acute-liver-injury
#5
Debora Bizzaro, Marika Crescenzi, Rosa Di Liddo, Diletta Arcidiacono, Andrea Cappon, Thomas Bertalot, Vincenzo Amodio, Alessia Tasso, Annalisa Stefani, Valentina Bertazzo, Giacomo Germani, Chiara Frasson, Giuseppe Basso, Pierpaolo Parnigotto, Malcolm Ronald Alison, Patrizia Burra, Maria Teresa Conconi, Francesco Paolo Russo
A sexual dimorphism in liver inflammation and repair was previously demonstrated. Its cellular dissection in the course of acute liver injury (ALI) was explored. BALB/c mice were treated with carbon tetrachloride (CCl4) by intraperitoneal injection and sacrificed after 3, 5 and 8 days. Histological and hepatic cell population analyses were performed. The correlation between androgen receptor (AR) expression and liver recruited inflammatory cells was investigated by treatment with the AR antagonist flutamide...
December 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29228569/the-effects-of-blueberry-anthocyanins-on-histone-acetylation-in-rat-liver-fibrosis
#6
Wei Zhan, Xin Liao, Ru-Jia Xie, Tian Tian, Lei Yu, Xing Liu, Jing Liu, Po Li, Bing Han, Ting Yang, Bei Zhang, Li-Jun Cai, Rui Li, Qin Yang
To determine the effects ofanthocyanins from blueberries on hepatic stellate cell (HSCs-T6) and on histone acetylation during liver fibrosis induced by CCl4 in rats. Fifty male SD rats weighing 180 ± 20g were randomly placed into a control group, a hepatic fibrosis group, a blueberry treatment group, a blueberry intervention group, and a natural recovery group. After the rats were sacrificed, the livers and the liver indexes were measured, and the pathological changes were observed by HE staining and Masson staining...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224792/white-butterfly-clerodendrum-volubile-leaf-extract-protects-against-carbon-tetrachloride-induced-hepatotoxicity-in-rats
#7
Olorunfemi R Molehin, Omotade I Oloyede, Kehinde A Idowu, Anne A Adeyanju, Ayorinde O Olowoyeye, Olusegun I Tubi, Olayemi E Komolafe, Aanuoluwapo S Gold
Currently, there is increasing attention towards flavonoids and phenolic compounds of plant origin because of their association with decrease in the incidence of cardiovascular diseases and different types of cancer. The present study investigates the protective effect of Clerodendrum volubile (C. volubile) methanolic extracts against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Control rats (group I) received olive oil (1 mL/kg, i.p.), group II received CCl4 in olive oil (1 ml/kg, i.p.) to induce hepatotoxicity, groups III, IV and V were pretreated with leaf extract of C...
December 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29222479/gdf15-deficiency-exacerbates-chronic-alcohol-and-carbon-tetrachloride-induced-liver-injury
#8
Hyo Kyun Chung, Jung Tae Kim, Hyeon-Woo Kim, Minjoo Kwon, So Yeon Kim, Minho Shong, Koon Soon Kim, Hyon-Seung Yi
Growth differentiation factor 15 (GDF15) has recently been shown to have an important role in the regulation of mitochondrial function and in the pathogenesis of complex human diseases. Nevertheless, the role of GDF15 in alcohol-induced or fibrotic liver diseases has yet to be determined. In this study, we demonstrate that alcohol- or carbon tetrachloride (CCl4)-mediated hepatic GDF15 production ameliorates liver inflammation and fibrosis. Alcohol directly enhanced GDF15 expression in primary hepatocytes, which led to increased oxygen consumption...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29217140/inhibition-of-canonical-wnt-signaling-pathway-by-%C3%AE-catenin-cbp-inhibitor-icg-001-ameliorates-liver-fibrosis-in-vivo-through-suppression-of-stromal-cxcl12
#9
Büsra Öztürk Akcora, Gert Storm, Ruchi Bansal
Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic morphological transformation into proliferative, contractile and ECM-producing myofibroblasts. In this study, we investigated the implication of canonical Wnt signaling pathway in HSCs and liver fibrogenesis. Canonical Wnt signaling pathway activation and inhibition using β-catenin/CBP inhibitor ICG001 was examined in-vitro in TGFβ-activated 3T3, LX2, primary human HSCs, and in-vivo in CCl4-induced acute liver injury mouse model...
December 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29215843/-influence-of-partial-hepatectomie-on-ammoniumdetoxications-function-of-liver-at-chronic-tetrachlorcarbon-hepatitis
#10
P N Savilov
The purpose. To study the effect of partial hepatectomy (PH) on the main ways of ammonia detoxication in the liver (synthesis of urea and glutamine) in chronic tetrachlorcarbon (CCl4) hepatitis. Methods. The experiments were performed on 165 white outbred rats (females) weighing 180-220 g Chronic CCl4-hepatitis was reproduced by subcutaneous injection of 50% CCl4 solution in olive oil (0.1 ml/100g of body weight,65 days, through the day with two two-week breaks between 6-7 and 13-14 injections). PH conducted electrocautery, removing part of the left lobe of the liver (15-20% by weight of the body) to 65th (and last) day of the introduction of the CCl4...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29215282/thermal-decomposition-of-phosgene-and-diphosgene
#11
Juan-Carlos Lizardo-Huerta, Baptiste Sirjean, Laurent Verdier, René Fournet, Pierre-Alexandre Glaude
Phosgene (COCl2) is a toxic compound used or formed in a wide range of applications. The understanding of its thermal decomposition for destruction processes or in the event of accidental fire of stored reserves is a major safety issue. In this study, a detailed chemical kinetic model for the thermal decomposition and combustion of phosgene and diphosgene is proposed for the first time. A large number of thermo-kinetic parameters were calculated using quantum chemistry and reaction rate theory. The model was validated against experimental pyrolysis data from the literature...
December 7, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29214688/nootkatone-confers-hepatoprotective-and-anti-fibrotic-actions-in-a-murine-model-of-liver-fibrosis-by-suppressing-oxidative-stress-inflammation-and-apoptosis
#12
Amani Kurdi, Kamal Hassan, Balaji Venkataraman, Mohanraj Rajesh
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29212506/chromosome-9p-copy-number-gains-involving-pd-l1-are-associated-with-a-specific-proliferation-and-immune-modulating-gene-expression-program-active-across-major-cancer-types
#13
Jan Budczies, Carsten Denkert, Balázs Győrffy, Peter Schirmacher, Albrecht Stenzinger
BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequately reflect the complex interaction between the tumor and the immune system. Recently, recurrent copy number gains (CNG) in chromosome 9p involving PD-L1 were detected in many cancer types including lung cancer, melanoma, bladder cancer, head and neck cancer, cervical cancer, soft tissue sarcoma, prostate cancer, gastric cancer, ovarian cancer, and triple-negative breast cancer...
December 6, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29203101/efficient-hepatoprotective-activity-of-cranberry-extract-against-ccl4-induced-hepatotoxicity-in-wistar-albino-rat-model-down-regulation-of-liver-enzymes-and-strong-antioxidant-activity
#14
Fahad Hussain, Arif Malik, Ujala Ayyaz, Hassan Shafique, Zohaib Rana, Zahid Hussain
OBJECTIVE: To investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using in-vivo animal model. METHODS: The hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)], and total protein (TP) contents in the serum...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29201496/platelets-prime-hematopoietic-and-vascular-niche-to-drive-angiocrine-mediated-liver-regeneration
#15
Koji Shido, Deebly Chavez, Zhongwei Cao, Jane Ko, Shahin Rafii, Bi-Sen Ding
In mammals, the livers regenerate after chemical injury or resection of hepatic lobe by hepatectomy. How liver regeneration is initiated after mass loss remains to be defined. Here, we report that following liver injury, activated platelets deploy SDF-1 and VEGF-A to stimulate CXCR7+ liver sinusoidal endothelial cell (LSEC) and VEGFR1+ myeloid cell, orchestrating hepatic regeneration. After carbon tetrachloride (CCl4) injection or hepatectomy, platelets and CD11b+VEGFR1+ myeloid cells were recruited LSEC, and liver regeneration in both models was impaired in thrombopoietin-deficient (Thpo-/-) mice lacking circulating platelets...
2017: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29200015/elevated-production-of-nociceptive-cc-chemokines-and-se-selectin-in-patients-with-low-back-pain-and-the-effects-of-spinal-manipulation-a-nonrandomized-clinical-trial
#16
Julita A Teodorczyk-Injeyan, Marion McGregor, John J Triano, Stephen H Injeyan
BACKGROUND: The involvement of inflammatory components in the pathophysiology of low back pain (LBP) is poorly understood. It has been suggested that spinal manipulative therapy (SMT) may exert anti-inflammatory effects. PURPOSE: The purpose of this study was to determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of nonspecific LBP and to evaluate the effect of SMT on that process. METHODS: Patients presenting with nonradicular, nonspecific LBP (minimum pain score 3 on 10-point visual analog scale) were recruited according to stringent inclusion criteria...
January 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29198003/liver-fibrosis-detection-and-staging-a-comparative-study-of-t1%C3%AF-mr-imaging-and-2d-real-time-shear-wave-elastography
#17
Ruo-Kun Li, Xin-Pin Ren, Fu-Hua Yan, Jin-Wei Qiang, Hui-Min Lin, Tao Wang, Hong-Fei Zhao, Wei-Bo Chen
PURPOSE: To compare the results of T1ρ MR imaging and 2D real-time shear-wave elastography (SWE) for liver fibrosis detection and staging. METHODS: Twenty-nine rabbit models of CCl4-induced liver fibrosis were established and six untreated rabbits served as controls. T1ρ MR imaging and 2D real-time SWE examination were performed at 2, 4, 6, 8, 10, and 12 weeks. T1ρ values and liver stiffness (LS) values were measured. Fibrosis was staged according to the METAVIR scoring system...
December 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29197526/pathway-analysis-of-differentially-expressed-genes-in-mycobacterium-bovis-challenged-bovine-macrophages
#18
Sanjeev Kumar Shukla, Shubhra Shukla, Anuj Chauhan, Sarvjeet, Rehan Khan, Anuj Ahuja, Lakshya Veer Singh, Nitin M Kamble, Anupam Dhasmana, Naveen Sharma, Bipin Chand, Ajay Vir Singh, Manjit Panigrahi
The immune signalling genes during challenge of bovine macrophages with bacterial products derived from disease causing bacteria in cattle were investigated. An in-vitro cell culture model were challenged to Mycobacterium bovis of bovine monocyte derived macrophages. Macrophages from healthy and already infected animals can both be fully activated during M. bovis infection. Analysis of mRNA abundance in peripheral blood mononuclear cells from M. bovis infected and non-infected cattle were performed as a controls...
November 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29197520/effects-of-pirfenidone-in-acute-and-sub-chronic-liver-fibrosis-and-an-initiation-promotion-cancer-model-in-the-mouse
#19
Oleksii Seniutkin, Shinji Furuya, Yu-Syuan Luo, Joseph A Cichocki, Hisataka Fukushima, Yuki Kato, Hiromi Sugimoto, Tomoko Matsumoto, Takeki Uehara, Ivan Rusyn
Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a drug approved for idiopathic pulmonary fibrosis and this study was focused on anti-fibrotic and anti-cancer potential of pirfenidone in the liver of male B6C3F1/J mice. In a dose-finding study, mice were treated with CCl4 (0...
November 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29197066/characterisation-of-the-properties-of-a-selective-orally-bioavailable-autotaxin-inhibitor-in-preclinical-models-of-advanced-stages-of-liver-fibrosis
#20
Manuel Baader, Tom Bretschneider, Andre Broermann, Joerg F Rippmann, Birgit Stierstorfer, Christian A Kuttruff, Michael Mark
BACKGROUND AND PURPOSE: Autotaxin (ATX) is a secreted phospholipase which hydrolyses lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). The extracellular signalling molecule LPA exerts its biological actions through activation of six G protein-coupled receptors expressed in various cell types including fibroblasts. Multiple preclinical studies using knockout animals, LPA receptor antagonists or ATX inhibitors have provided evidence for a potential role of the ATX/LPA axis in tissue fibrosis...
December 2, 2017: British Journal of Pharmacology
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