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https://www.readbyqxmd.com/read/29449436/mixed-species-rnaseq-analysis-of-human-lymphoma-cells-adhering-to-mouse-stromal-cells-identifies-a-core-gene-set-that-is-also-differentially-expressed-in-the-lymph-node-microenvironment-of-mantle-cell-lymphoma-and-chronic-lymphocytic-leukemia-patients
#1
Gustav Arvidsson, Johan Henriksson, Birgitta Sander, Anthony P Wright
A subset of hematological cancer patients is refractory to treatment or suffers relapse, due in part to minimal residual disease, whereby some cancer cells survive treatment. Cell-adhesion mediated drug resistance is an important mechanism, whereby cancer cells receive survival signals via interaction with e.g. stromal cells. No genome-wide studies of in vitro systems have yet been performed to compare gene expression in different cell subsets within a co-culture and cells grown separately. Using RNA sequencing and species-specific read mapping, we compared transcript levels in human Jeko-1 mantle cell lymphoma cells stably adhered to mouse MS-5 stromal cells or in suspension within a co-culture or cultured separately as well as in stromal cells in co-culture or in separate culture...
February 15, 2018: Haematologica
https://www.readbyqxmd.com/read/29445190/the-chemokine-receptor-ccr10-promotes-inflammation-driven-hepatocarcinogenesis-via-pi3k-akt-pathway-activation
#2
Qiong Wu, Jin-Xian Chen, Yu Chen, Li-Li Cai, Xiao-Zhong Wang, Wu-Hua Guo, Jian-Feng Zheng
G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflammation-driven hepatocarcinogenesis. Via a targeted gene expression microarray screening alterations in GPCR family gene expression, we found CCR10 to be significantly upregulated in hepatocytes isolated from inflammation-driven human HCC tumors and matching paracancerous tissues...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29441888/anti-fibrotic-potential-of-a-matthiola-arabica-isothiocyanates-rich-fraction-impact-on-oxidative-stress-inflammatory-and-fibrosis-markers
#3
E D Mohammed, R N El-Naga, R A Lotfy, A A Al-Gendy, E El-Demerdash
The present study is the first one to investigate the glucosinolates (GLS) profile and anti-fibrotic effect of isothiocyanates (ITCs) rich fraction of Matthiola arabica (Brassicaceae) using an experimental model of liver fibrosis in rats. Five GLS (ethyl glucosinolate, gluconapin, glucodehydroerucin, glucoerucin and glucoraphanin) were identified by gas liquid chromatography-mass spectrometric (GLC-MS) analysis of their hydrolysis products, produced by the natural autolysis and exogenous myrosinase hydrolysis using one and two units of the enzyme...
October 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29434856/high-fat-diet-induced-adipokine-and-cytokine-alterations-promote-the-progression-of-prostate-cancer-in-vivo-and-in-vitro
#4
Meng-Bo Hu, Hua Xu, Wen-Hui Zhu, Pei-De Bai, Ji-Meng Hu, Tian Yang, Hao-Wen Jiang, Qiang Ding
High-fat diet (HFD) -induced obesity is associated with more aggressive and lethal prostate cancer (PCa) in males, although the exact underlying mechanisms remain unclear. In the present study, transgenic adenocarcinoma of mouse prostate (TRAMP) models fed on an HFD (40% fat) or a control diet (CD; 16% fat) were generated, and cancer differentiation, local invasion and metastasis were compared at 20, 24 and 28 weeks. Mouse sera from each group were collected, and adipokines and cytokines were measured using multiplex immunoassays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433393/epimedium-koreanum-ameliorates-oxidative-stress-mediated-liver-injury-by-activating-nuclear-factor-erythroid-2-related-factor-2
#5
Ji Yun Jung, Sang Mi Park, Hae Li Ko, Jong Rok Lee, Chung A Park, Sung Hui Byun, Sae Kwang Ku, Il Je Cho, Sang Chan Kim
Oxidative stress induced by reactive oxygen species is the main cause of various liver diseases. This study investigated the hepatoprotective effect of Epimedium koreanum Nakai water extract (EKE) against arachidonic acid (AA)[Formula: see text]+[Formula: see text]iron-mediated cytotoxicity in HepG2 cells and carbon tetrachloride (CCl4-)-mediated acute liver injury in mice. Pretreatment with EKE (30 and 100μg/mL) significantly inhibited AA[Formula: see text]+[Formula: see text]iron-mediated cytotoxicity in HepG2 cells by preventing changes in the expression of cleaved caspase-3 and poly(ADP-ribose) polymerase...
February 12, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29427621/brg1-promotes-liver-fibrosis-via-activation-of-hepatic-stellate-cells
#6
Haijie Li, Jingqin Lan, Caishun Han, Kaixuan Guo, Guihua Wang, Junbo Hu, Jianping Gong, Xuelai Luo, Zhixin Cao
Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive environment for cancer development, is characterized by the persistent deposition of extracellular matrix components mainly derived from activated hepatic stellate cells (HSCs). Brg1, the core subunit of the SWI/SNF chromatin remodeling complex, has been proved to associated with nonalcoholic steatohepatitis which may progress to cirrhosis. Herein, we determined whether Brg1 regulates liver fibrosis and examined its mechanism by focusing on HSCs activation...
February 7, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29425464/renin-angiotensin-system-inhibition-ameliorates-ccl4-induced-liver-fibrosis-in-mice-through-the-inactivation-of-nuclear-transcription-factor-kappa-b
#7
Sameh Saber, Amr A A Mahmoud, Noha Said Helal, Eman El-Ahwany, Rasha Abdelghany
Therapeutic interventions for liver fibrosis are still limited due to the complicated molecular pathogenesis. Renin-angiotensin system (RAS) seems to contribute to the development of hepatic fibrosis. Therefore, we aimed to examine the effect of RAS inhibition on CCl4-induced liver fibrosis. Mice were treated with silymarin (30 mg kg-1), perindopril (1 mg kg-1), fosinopril (2 mg kg-1), or losartan (10 mg kg-1). The administration RAS inhibitors improved liver histology and decreased protein expression of alpha smooth muscle actin (α-SMA) and hepatic content of hydroxyproline...
February 9, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29425397/cholangiocyte-derived-exosomal-long-noncoding-rna-h19-promotes-cholestatic-liver-injury-in-mouse-and-human
#8
Xiaojiaoyang Li, Runping Liu, Zhiming Huang, Emily C Gurley, Xuan Wang, Juan Wang, Hongliang He, Hu Yang, Guanhua Lai, Luyong Zhang, Jasmohan S Bajaj, Melanie White, William M Pandak, Phillip B Hylemon, Huiping Zhou
Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released by a variety of cells including cholangiocytes. Exosome-mediated cell-cell communication can modulate various cellular functions by transferring a variety of intracellular components to target cells. Our recent studies indicate that the long non-coding RNA H19 is mainly expressed in cholangiocytes and its aberrant expression is associated with significant down-regulation of small heterodimer partner (SHP) in hepatocytes and cholestatic liver injury in multidrug resistance 2 knockout (Mdr2-/- ) mice...
February 9, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29424349/therapeutic-effects-of-n-acetyl-l-cysteine-on-liver-damage-induced-by-long-term-ccl4-administration
#9
REVIEW
Oľga Otrubová, Ladislav Turecký, Oľga Uličná, Pavol Janega, Ján Luha, Jana Muchová
N-acetyl-L-cysteine (NAC) is a drug routinely used in several health problems, e.g. liver damage. There is some information emerged on its negative effects in certain situations. The aim of our study was to examine its ability to influence liver damage induced by long-term burden. We induced liver damage by CCl4 (10 weeks) and monitored the impact of parallel NAC administration (daily 150 mg/kg of b.w.) on liver morphology and some biochemical parameters (triacylglycerols, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, bile acids, proteins, albumins and cholinesterase)...
January 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29420858/endothelial-notch-activation-reshapes-the-angiocrine-of-sinusoidal-endothelia-to-aggravate-liver-fibrosis-and-blunt-regeneration
#10
Juan-Li Duan, Bai Ruan, Xian-Chun Yan, Liang Liang, Ping Song, Zi-Yan Yang, Yuan Liu, Ke-Feng Dou, Hua Han, Lin Wang
Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in endothelial cells (ECs). In the current study, Notch signaling was activated by inducible EC-specific expression of the Notch intracellular domain (NIC). We found that endothelial Notch activation damaged liver homeostasis. Notch activation resulted in decreased fenestration and increased basement membrane, and a gene expression profile with decreased LSEC-associated genes and increased continuous EC-associated genes, suggesting LSEC dedifferentiation...
February 8, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29416777/staging-of-rat-liver-fibrosis-using-monoexponential-stretched-exponential-and-diffusion-kurtosis-models-with-diffusion-weighted-imaging-magnetic-resonance
#11
Genwen Hu, Wen Liang, Mingxiang Wu, Queenie Chan, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
Early diagnosis of liver fibrosis is important. The objective of this study was to explore the characteristics and to assess the accuracy of monoexponential, stretched exponential models (SEM), and diffusion kurtosis imaging (DKI) with diffusion-weighted imaging (DWI)-magnetic resonance imaging (MRI) in various stages of liver fibrosis in two standard rat models induced by carbon tetrachloride (CCl4) and biliary duct ligation (BDL). Parameters (ADC, Dapp, Kapp, DDC, α) were measured with a 3.0T MRI. Liver fibrosis stages (F0-F4) were defined by METAVIR scoring...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416088/ephb2-receptor-tyrosine-kinase-promotes-hepatic-fibrogenesis-in-mice-via-activation-of-hepatic-stellate-cells
#12
Patrice N Mimche, Choon M Lee, Sylvie M Mimche, Manoj Thapa, Arash Grakoui, Mark Henkemeyer, Tracey J Lamb
Hepatic fibrosis is the result of an excessive wound-healing response subsequent to chronic liver injury. A feature of liver fibrogenesis is the secretion and deposition of extracellular matrix proteins by activated hepatic stellate cells (HSCs). Here we report that upregulation of EphB2 is a prominent feature of two mouse models of hepatic fibrosis and also observed in humans with liver cirrhosis. EphB2 is upregulated and activated in mouse HSCs following chronic carbon tetrachloride (CCl4) exposure. Moreover, we show that EphB2 deficiency attenuates liver fibrosis and inflammation and this is correlated with an overall reduction in pro-fibrotic markers, inflammatory chemokines and cytokines...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29414645/activation-of-autophagy-is-required-for-oroxylin-a-to-alleviate-carbon-tetrachloride-induced-liver-fibrosis-and-hepatic-stellate-cell-activation
#13
Weiwei Chen, Zili Zhang, Zhen Yao, Ling Wang, Feng Zhang, Jiangjuan Shao, Anping Chen, Shizhong Zheng
Liver fibrosis is a reversible pathophysiological process correlated with intense repair and cicatrization mechanisms, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide. Interestingly, the use of natural products as a realistic option for the treatment of liver fibrosis has broadly been accepted. Oroxylin A, a safe and natural product, shows a wide range of pharmacological activities such as anti-inflammatory, anti-oxidant, and anti-tumor properties. However, the effects of Oroxylin A on liver fibrosis remain poorly understood...
January 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29410429/transcriptome-of-porcine-pbmcs-over-two-generations-reveals-key-genes-and-pathways-associated-with-variable-antibody-responses-post-prrsv-vaccination
#14
Ting Yang, Fengxia Zhang, Liwei Zhai, Weiyong He, Zhen Tan, Yangyang Sun, Yuan Wang, Lei Liu, Chao Ning, Weiliang Zhou, Hong Ao, Chuduan Wang, Ying Yu
Porcine reproductive and respiratory syndrome virus (PRRSV) is a virus susceptible to antibody dependent enhancement, causing reproductive failures in sows and preweaning mortality of piglets. Modified-live virus (MLV) vaccines are used to control PRRS in swine herds. However, immunized sows and piglets often generate variable antibody levels. This study aimed to detect significant genes and pathways involved in antibody responsiveness of pregnant sows and their offspring post-PRRSV vaccination. RNA sequencing was conducted on peripheral blood-mononuclear cells (PBMCs), which were isolated from pregnant sows and their piglets with high (HA), median (MA), and low (LA) PRRS antibody levels following vaccination...
February 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29406832/coagonist-of-glp-1-and-glucagon-receptors-ameliorates-non-alcoholic-fatty-liver-disease
#15
Vishal J Patel, Amit Arvind Joharapurkar, Samadhan Kshirsagar, Maulik S Patel, Brijesh K Sutariya, Hiren M Patel, Dheerendra Pandey, Dipam Patel, Ramchandra Ranvir, Shekhar Kadam, Rajesh Bahekar, Mukul Jain
Nonalcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. Coagonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) are under clinical investigation for the treatment of obesity and type 2 diabetes. In this study, we have demonstrated the effect of a balanced coagonist in the treatment of NAFLD using mice models. GLP-1R agonist exendin-4, glucagon, and coagonist (Aib2 C24 Chimera2) were administered to C57BL6/J mice, in which NAFLD was induced by carbon tetrachloride (CCl4) treatment after in high fat diet (HFD) feeding, and CDAHFD (choline-deficient, L-amino acid-defined, HFD)...
February 6, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29404486/a-canine-liver-fibrosis-model-to-develop-a-therapy-for-liver-cirrhosis-using-cultured-bone-marrow-derived-cells
#16
Takashi Matsuda, Taro Takami, Ryo Sasaki, Tatsuro Nishimura, Yuki Aibe, Bruno Diaz Paredes, Luiz Fernando Quintanilha, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Naoki Yamamoto, Kenji Tani, Shuji Terai, Yasuho Taura, Isao Sakaida
We have been developing a therapy for liver cirrhosis using cultured autologous bone marrow-derived mesenchymal stem cells (BMSCs). Before human clinical trials can be considered, the safety and efficacy of BMSC infusion in medium to large animals must be confirmed; thus, we developed a canine liver fibrosis model. A small amount of bone marrow fluid was aspirated from the canine humerus to assess the characteristics of BMSCs. We implanted a venous catheter in the stomach and a subcutaneous infusion port in the back of the neck of each canine...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29404476/the-new-generation-pan-peroxisome-proliferator-activated-receptor-agonist-iva337-protects-the-liver-from-metabolic-disorders-and-fibrosis
#17
Guillaume Wettstein, Jean-Michel Luccarini, Laurence Poekes, Patrick Faye, Francine Kupkowski, Vanessa Adarbes, Evelyne Defrêne, Céline Estivalet, Xavier Gawronski, Ingrid Jantzen, Alain Philippot, Julien Tessier, Pascale Tuyaa-Boustugue, Fiona Oakley, Derek A Mann, Isabelle Leclercq, Sven Francque, Irena Konstantinova, Pierre Broqua, Jean-Louis Junien
IVA337 is a pan-peroxisome proliferator-activated receptor (PPAR) agonist with moderate and well-balanced activity on the three PPAR isoforms (α, γ, δ). PPARs are regulators of lipid metabolism, inflammation, insulin resistance, and fibrogenesis. Different single or dual PPAR agonists have been investigated for their therapeutic potential in nonalcoholic steatohepatitis (NASH), a chronic liver condition in which steatosis coexists with necroinflammation, potentially leading to liver fibrosis and cirrhosis...
August 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29404442/generation-of-safe-and-therapeutically-effective-human-induced-pluripotent-stem-cell-derived-hepatocyte-like-cells-for-regenerative-medicine
#18
Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi
Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells are expected to be applied for regenerative medicine. In this study, we attempted to generate safe and therapeutically effective human iPS-HLCs for hepatocyte transplantation. First, human iPS-HLCs were generated from a human leukocyte antigen-homozygous donor on the assumption that the allogenic transplantation might be carried out. Highly efficient hepatocyte differentiation was performed under a feeder-free condition using human recombinant laminin 111, laminin 511, and type IV collagen...
December 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29404036/hepatoprotective-activity-of-macrothelypteris-torresiana-gaudich-aerial-parts-against-ccl4-induced-hepatotoxicity-in-rodents-and-analysis-of-polyphenolic-compounds-by-hptlc
#19
Sumanta Mondal, Debjit Ghosh, Seru Ganapaty, Surya Vamsi Gokul Chekuboyina, Manisha Samal
Macrothelypteris torresiana is a fern species belonging to family Thelypteridaceae. The present study was conducted to evaluate hepatoprotective potential of ethanol extract from M. torresiana aerial parts (EEMTAP) and detect the polyphenolic compounds present in the extract using high performance thin layer chromatography (HPTLC). Hepatoprotective potential of EEMTAP were tested at doses of 300 and 600 mg/kg, per os (p.o.), on Wistar albino rats. The extract and silymarin treated animal groups showed significant decrease in activities of different biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), alkaline phosphatase (ALP), which were elevated by carbon tetrachloride (CCl4) intoxication...
June 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29402559/spectra-structure-correlations-in-nir-region-spectroscopic-and-anharmonic-dft-study-of-n-hexanol-cyclohexanol-and-phenol
#20
Krzysztof B Beć, Justyna Grabska, Mirosław A Czarnecki
We investigated near-infrared (7500-4000 cm-1) spectra of n-hexanol, cyclohexanol and phenol in CCl4 (0.2 M) by using anharmonic quantum calculations. These molecules represent three major kinds of alcohols; linear and cyclic aliphatic, and aromatic ones. Vibrational second-order perturbation theory (VPT2) was employed to calculate the first overtones and binary combination modes and to reproduce the experimental NIR spectra. The level of conformational flexibility of these three alcohols varies from one stable conformer of phenol through four conformers of cyclohexanol to few hundreds conformers in the case of n-hexanol...
February 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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