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https://www.readbyqxmd.com/read/28525983/polymorphisms-of-t-helper-cell-cytokine-associated-genes-and-survival-of-hemodialysis-patients-a-prospective-study
#1
Alicja E Grzegorzewska, Monika K Świderska, Adrianna Mostowska, Wojciech Warchoł, Paweł P Jagodziński
BACKGROUND: Circulating pro-inflammatory cytokines were associated with increased relative mortality risk, while immune parameters reflecting improved T-cell function were predictors of survival in hemodialysis (HD) patients. We evaluated in the prospective study whether variants in T helper cell cytokine-associated genes are determinants of mortality in HD patients. METHODS: The study was carried out in 532 prevalent HD subjects who were followed-up for 7 years...
May 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28525592/neurosyphilis-increases-hiv-associated-central-nervous-system-inflammation-but-does-not-explain-cognitive-impairment-in-hiv-infected-individuals-with-syphilis
#2
Emily L Ho, Clare L Maxwell, Shelia B Dunaway, Sharon K Sahi, Lauren C Tantalo, Sheila A Lukehart, Christina M Marra
Background: HIV-infected individuals with previous syphilis have cognitive impairment. We tested the hypothesis that neurosyphilis causes cognitive impairment in HIV by amplifying HIV-related CNS inflammation. Methods: 132 HIV-infected participants enrolled in a study of CSF abnormalities in syphilis underwent the mental alternation test (MAT), venipuncture and lumbar puncture. CSF concentrations of chemokine (C-X-C motif) ligand 10 (CXCL10), chemokine (C-C motif) ligand 2 (CCL2) and neurofilament light (NFL) were determined by commercial assays...
May 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28523567/peripheral-viral-challenge-triggers-hippocampal-production-of-inflammatory-proteins
#3
Tiffany Petrisko, Gregory Konat
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We have modeled this comorbidity by demonstrating that intraperitoneal (ip) injection of the conventional viral mimetic, polyinosinic-polycytidylic acid (PIC), renders the brain hypersusceptible to seizures induced by kainic acid (KA). At the molecular level, the hippocampus, which is the ictal site of KA-induced seizures, exhibits upregulated expression of messages encoding several inflammatory genes. Here, we profiled temporal expression of these genes at the protein level...
May 18, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28523000/mast-cells-and-mcpt4-chymase-promote-renal-impairment-after-partial-ureteral-obstruction
#4
Maguelonne Pons, Liza Ali, Walid Beghdadi, Luca Danelli, Marianne Alison, Lydia Celia Madjène, Jessica Calvo, Julien Claver, Shamila Vibhushan, Magnus Åbrink, Gunnar Pejler, Marie-Laurence Poli-Mérol, Michel Peuchmaur, Alaa El Ghoneimi, Ulrich Blank
Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data showing significant mast cell (MC) infiltration in patients, we investigated the role of MC and murine MCPT4, a MC-released chymase, in pUUO using MC- (W(sh/sh)), MCPT4-deficient (Mcpt4(-/-)), and wild-type (WT) mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28522564/decreased-phosphatase-pten-amplifies-pi3k-signaling-and-enhances-pro-inflammatory-cytokine-release-in-copd
#5
Satoru Yanagisawa, Jonathan R Baker, Chaitanya Vuppusetty, Peter Fenwick, Louise E Donnelly, Kazuhiro Ito, Peter J Barnes
The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. Our aim was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN expression and activity were measured in the peripheral lung of COPD patients compared to smoking and non-smoking controls. The direct influence of cigarette smoke extract (CSE) on PTEN expression was assessed using primary lung epithelial cells and a cell line (BEAS-2B) in the presence or absence of L-buthionine-sulfoximine (BSO) to deplete intracellular glutathione...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28522263/serum-concentrations-of-the-axonal-injury-marker-neurofilament-light-protein-are-not-influenced-by-blood-brain-barrier-permeability
#6
Marie Kalm, Martina Boström, Åsa Sandelius, Yohanna Eriksson, C Joakim Ek, Kaj Blennow, Thomas Björk-Eriksson, Henrik Zetterberg
A blood biomarker to monitor individual susceptibility to neuronal injury from cranial radiotherapy could potentially help to individualize radiation treatment and thereby reduce the incidence and severity of late effects. An important feature of such a blood biomarker is that its concentration is not confounded by varying degrees of release from the brain into the blood across the blood-brain barrier (BBB). In this study, we investigated serum neurofilament light protein (NFL) concentrations in 21-day old mice following a single dose of cranial irradiation (8 Gy)...
May 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28516946/ccl2-ccr2-signalling-recruits-a-distinct-fetal-microchimeric-population-that-rescues-delayed-maternal-wound-healing
#7
Mathieu Castela, Dany Nassar, Maria Sbeih, Marie Jachiet, Zhe Wang, Selim Aractingi
Foetal microchimeric cells (FMCs) traffic into maternal circulation during pregnancy and persist for decades after delivery. Upon maternal injury, FMCs migrate to affected sites where they participate in tissue healing. However, the specific signals regulating the trafficking of FMCs to injury sites had to be identified. Here we report that, in mice, a subset of FMCs implicated in tissue repair displays CD11b(+) CD34(+) CD31(+) phenotype and highly express C-C chemokine receptor 2 (Ccr2). The Ccr2 ligand chemokine ligand 2 (Ccl2) enhances the recruitment of FMCs to maternal wounds where these cells transdifferentiate into endothelial cells and stimulate angiogenesis through Cxcl1 secretion...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28514653/the-presence-of-interleukin-13-at-pancreatic-adm-panin-lesions-alters-macrophage-populations-and-mediates-pancreatic-tumorigenesis
#8
Geou-Yarh Liou, Ligia Bastea, Alicia Fleming, Heike Döppler, Brandy H Edenfield, David W Dawson, Lizhi Zhang, Nabeel Bardeesy, Peter Storz
The contributions of the innate immune system to the development of pancreatic cancer are still ill defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (acinar-to-ductal metaplasia [ADM]), which then gives rise to pancreatic intraepithelial neoplasia (PanIN) when oncogenic KRas is present. However, it remains unclear when and how this inflammatory macrophage population is replaced by tumor-promoting macrophages. Here, we demonstrate the presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1+ alternatively activated macrophages, at ADM/PanIN lesions...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28513976/gingerenone-a-attenuates-monocyte-endothelial-adhesion-via-suppression-of-i-kappa-b-kinase-phosphorylation
#9
Hee Joo Kim, Joe Eun Son, Jae Hwan Kim, Charles C Lee, Hee Yang, Soonham Sami Yaghmoor, Youssri Ahmed, Jehad Mustafa Yousef, Khalid Omer Abualnaja, Abdulrahman Labeed Al-Malki, Taha Abdullah Kumosani, Jung Han Yoon Park, Chang Yong Lee, Jong-Eun Kim, Ki Won Lee
During the early stages of atherosclerosis, monocytes bind and migrate into the endothelial layer, promoting inflammation within the aorta. In order to prevent the development of atherosclerosis, it is critical to inhibit such inflammation. The therapeutic effects of ginger have been investigated in several models of cardiovascular disease. However, although a number of previous studies have focused on specific compounds, the mechanisms of action responsible remain unclear. Here, we investigated five major compounds present in ginger, and observed that gingerenone A exhibited the strongest inhibitory effects against tumor necrosis factor (TNF)- α and lipopolysaccharide (LPS) induced monocyte-endothelial adhesion...
May 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28512644/analysis-of-serum-cytokines-and-single-nucleotide-polymorphisms-of-sod1-sod2-and-cat-in-erysipelas-patients
#10
Charles C Emene, Irina E Kravchenko, Gulnaz I Aibatova, Albert A Rizvanov
Increased free radical production had been documented in group A (β-hemolytic) streptococcus infection cases. Comparing 71 erysipelas patients to 55 age-matched healthy individuals, we sought for CAT, SOD1, and SOD2 single polymorphism mutation (SNPs) interactions with erysipelas' predisposition and serum cytokine levels in the acute and recovery phases of erysipelas infection. Whereas female patients had a higher predisposition to erysipelas, male patients were prone to having a facial localization of the infection...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28511292/gut-inflammation-in-hla-b27-transgenic-rats-alters-the-monocyte-compartment-and-its-osteoclastogenic-potential
#11
Cecilia Ansalone, Lotta Utriainen, Simon Milling, Carl S Goodyear
Objective To investigate the relationship between intestinal inflammation and the central and peripheral innate immune system, in the pathogenesis of HLA-B27 associated spondyloarthritis. Methods The myeloid compartment of the bone marrow and blood of HLA-B27 transgenic (B27), control HLA-B7 transgenic (B7), and non-transgenic rats were evaluated by flow cytometry. Plasma from rats were assessed by ELISA for CCL2 and IL-1α levels. Rats were treated for 4 weeks with antibiotics and the blood and bone marrow myeloid compartments were evaluated by flow cytometry...
May 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28510435/carbenes-as-electron-pair-donors-to-co2-for-c%C3%A2-%C3%A2-%C3%A2-c-tetrel-bonds-and-c-c-covalent-bonds
#12
Janet E Del Bene, Ibon Alkorta, José Elguero
Ab initio MP2/aug'-cc-pVTZ calculations have been carried out to identify stable complexes and molecules and the transition structures that interconvert them on the potential surfaces of ten singlet carbene bases acting as electron-pair donors to CO2. The carbene bases include cyclic C(NHCH)2 or NHC, C(NH2)2, an oxygen heterocyclic carbene C(OCH)2 or OHC, C(OH)2, C(CH3)2, cyclic C3H2, CCCH2, CCl2, CCH2, and CF2. Carbene:CO2 complexes stabilized by C···C tetrel bonds have been found on all potential surfaces, whereas carbene-CO2 molecules stabilized by C-C covalent bonds have been found on eight surfaces...
May 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28508873/mutant-kras-promotes-malignant-pleural-effusion-formation
#13
Theodora Αgalioti, Anastasios D Giannou, Anthi C Krontira, Nikolaos I Kanellakis, Danai Kati, Malamati Vreka, Mario Pepe, Μagda Spella, Ioannis Lilis, Dimitra E Zazara, Eirini Nikolouli, Nikolitsa Spiropoulou, Andreas Papadakis, Konstantina Papadia, Apostolos Voulgaridis, Vaggelis Harokopos, Panagiota Stamou, Silke Meiners, Oliver Eickelberg, Linda A Snyder, Sophia G Antimisiaris, Dimitrios Kardamakis, Ioannis Psallidas, Antonia Μarazioti, Georgios T Stathopoulos
Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for the development of MPE are still obscure. Here we show that mutant KRAS is important for MPE induction in mice. Pleural disseminated, mutant KRAS bearing tumour cells upregulate and systemically release chemokine ligand 2 (CCL2) into the bloodstream to mobilize myeloid cells from the host bone marrow to the pleural space via the spleen. These cells promote MPE formation, as indicated by splenectomy and splenocyte restoration experiments...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28507122/control-of-metastatic-niche-formation-by-targeting-apba3-mint3-in-inflammatory-monocytes
#14
Toshiro Hara, Hiroki J Nakaoka, Tetsuro Hayashi, Kouhei Mimura, Daisuke Hoshino, Masahiro Inoue, Fumitaka Nagamura, Yoshinori Murakami, Motoharu Seiki, Takeharu Sakamoto
Cancer metastasis is intricately orchestrated by both cancer and normal cells, such as endothelial cells and macrophages. Monocytes/macrophages, which are often co-opted by cancer cells and promote tumor malignancy, acquire more than half of their energy from glycolysis even during normoxic conditions. This glycolytic activity is maintained during normoxia by the functions of hypoxia inducible factor 1 (HIF-1) and its activator APBA3. The mechanism by which APBA3 inhibition partially suppresses macrophage function and affects cancer metastasis is of interest in view of avoidance of the adverse effects of complete suppression of macrophage function during therapy...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28507028/rig-i-like-receptor-triggering-by-dengue-virus-drives-dendritic-cell-immune-activation-and-th1-differentiation
#15
Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek
Dengue virus (DENV) causes 400 million infections annually and is one of several viruses that can cause viral hemorrhagic fever, which is characterized by uncontrolled immune activation resulting in high fever and internal bleeding. Although the underlying mechanisms are unknown, massive cytokine secretion is thought to be involved. Dendritic cells (DCs) are the main target cells of DENV, and we investigated their role in DENV-induced cytokine production and adaptive immune responses. DENV infection induced DC maturation and secretion of IL-1β, IL-6, and TNF...
May 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28506464/recruited-monocytes-and-type-2-immunity-promote-lung-regeneration-following-pneumonectomy
#16
Andrew J Lechner, Ian H Driver, Jinwoo Lee, Carmen M Conroy, Abigail Nagle, Richard M Locksley, Jason R Rock
To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes...
May 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28506046/interaction-between-trichomonas-vaginalis-and-the-prostate-epithelium
#17
Jung-Hyun Kim, Ik-Hwan Han, Sang-Su Kim, Soon-Jung Park, Duk-Young Min, Myoung-Hee Ahn, Jae-Sook Ryu
Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T...
April 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28505368/farnesoid-x-receptor-protects-against-low-dose-carbon-tetrachloride-induced-liver-injury-through-the-taurocholate-jnk-pathway
#18
Shogo Takahashi, Naoki Tanaka, Srujana Golla, Tatsuki Fukami, Kristopher W Krausz, Marianne A Polunas, Blair C Weig, Yusuke Masuo, Cen Xie, Changtao Jiang, Frank J Gonzalez
Hepatotoxicity is of major concern for humans exposed to industrial chemicals and drugs. Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism, enhanced the sensitivity to liver injury in mice after toxicant exposure, but the precise mechanism remains unclear. In this study, the interconnection between BA metabolism, FXR, and chemically-induced hepatotoxicity was investigated using metabolomics, Fxr-null mice and hepatocytes, and adenovirus. A single low-dose intraperitoneal injection of carbon tetrachloride (CCl4), an inducer of acute hepatitis in mice, resulted in more severe hepatocyte damage and higher induction of pro-inflammatory mediators, such as chemokine (C-C motif) ligand 2 (Ccl2), in Fxr-null mice...
May 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28504685/spleen-derived-lipocalin-2-in-the-portal-vein-regulates-kupffer-cells-activation-and-attenuates-the-development-of-liver-fibrosis-in-mice
#19
Tomonori Aoyama, Kyoko Kuwahara-Arai, Akira Uchiyama, Kazuyoshi Kon, Hironao Okubo, Shunhei Yamashina, Kenichi Ikejima, Shigehiro Kokubu, Akihisa Miyazaki, Sumio Watanabe
The liver has an immune tolerance against gut-derived products from the portal vein (PV). A disruption of the gut-liver axis leads to liver injury and fibrosis. The spleen is connected to the PV and regulates immune functions. However, possible splenic effects on liver fibrosis development are unclear. Lipocalin-2 (Lcn2) is an antimicrobial protein that regulates macrophage activation. To clarify the role of the spleen in liver fibrosis development, we induced liver fibrosis in mice after splenectomy, and investigated liver fibrosis development...
May 15, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28501927/cytokine-gene-polymorphism-associations-with-congenital-cytomegalovirus-infection-and-sensorineural-hearing-loss
#20
B Kasztelewicz, J Czech-Kowalska, B Lipka, B Milewska-Bobula, M K Borszewska-Kornacka, J Romańska, K Dzierżanowska-Fangrat
Cytomegalovirus (CMV) is the most common viral agent of congenital infections and a leading nongenetic cause of sensorineural hearing loss (SNHL). The host immunologic factors that render a developing foetus prone to intrauterine CMV infection and development of hearing loss are unknown. The aim of this study was to assess the potential associations between the polymorphisms within cytokine and cytokine receptors genes, and the risk of congenital CMV infection, and the hearing outcome. A panel of 11 candidate single nucleotide polymorphisms (SNPs): TNF rs1799964, TNF rs1800629, TNFRSF1A rs4149570, IL1B rs16944, IL1B rs1143634, IL10 rs1800896, IL10RA rs4252279, IL12B rs3212227, CCL2 rs1024611, CCL2 rs13900, CCR5 rs333 was genotyped in 470 infants (72 with confirmed intrauterine CMV infection and 398 uninfected controls), and related to congenital CMV infection, and the outcome...
May 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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