Hao Peng, Shan Xin, Susanne Pfeiffer, Constanze Müller, Juliane Merl-Pham, Stefanie M Hauck, Patrick N Harter, Daniel Spitzer, Kavi Devraj, Borys Varynskyi, Thomas Arzberger, Stefan Momma, Joel A Schick
The progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive species with lipid peroxidation is ferroptosis, which shows hallmarks of both programmed and necrotic death in vitro. While evidence of ferroptosis in neurodegenerative disease is indicated by iron accumulation and involvement of lipids, a stable marker for ferroptosis has not been identified. Its prevalence is thus undetermined in human pathophysiology, impeding recognition of disease areas and clinical investigations with candidate drugs...
April 23, 2024: Cell Death & Disease